17,189 results match your criteria Alcoholic Fatty Liver


Liver Fibrosis, Not Steatosis, Associates with Long-Term Outcomes in Ischaemic Stroke Patients.

Cerebrovasc Dis 2019 Feb 14;47(1-2):32-39. Epub 2019 Feb 14.

Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of

Background: To investigate whether there are differences in long-term all-cause and cardiovascular mortality according to the burden of liver fibrosis or steatosis in patients with ischaemic stroke or transient ischaemic attack (TIA). -Methods: Consecutive patients with acute ischaemic stroke or TIA who underwent transient elastography (TE) from January 2014 to December 2014 were considered eligible. The influence of liver fibrosis or steatosis, assessed via TE, on long-term outcomes was investigated using Cox proportional hazard models. Read More

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http://dx.doi.org/10.1159/000497069DOI Listing
February 2019

Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University Hospital of Verona, Verona, Italy. Electronic address:

Aim: - Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD.

Methods: - We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Read More

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http://dx.doi.org/10.1016/j.diabet.2019.01.011DOI Listing
February 2019

Soluble fibers improve metabolic syndrome but may cause liver disease and hepatocellular carcinoma.

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY, 10032, USA.

Nearly 25% of the world's population is suffering from non-alcoholic fatty liver disease (NAFLD), which is closely associated with obesity and type 2 diabetes. NAFLD may progress to the development of non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). With efficient medical therapies lacking, modifications of life style and diet are considered the best options for the prevention and treatment of NAFLD. Read More

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http://dx.doi.org/10.1002/hep.30565DOI Listing
February 2019

Drug-Induced Steatosis and Steatohepatitis: The Search for Novel Serum Biomarkers Among Potential Biomarkers for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis.

Drug Saf 2019 Feb 14. Epub 2019 Feb 14.

Indiana University School of Medicine, Indianapolis, IN, USA.

Drug-induced steatosis (DIS) and drug-induced steatohepatitis (DISH) are two of several types of drug-induced liver injury (DILI). They can be caused by various drugs and may present as acute, potentially lethal disorders or as chronic slowly progressive liver injury. Despite the fact that they are distinct disorders, the slow progressive forms of DIS and DISH are often confused with or misdiagnosed as non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH), which are much more common and, by definition, not caused by drugs. Read More

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http://dx.doi.org/10.1007/s40264-018-00790-2DOI Listing
February 2019

Review article: iron disturbances in chronic liver diseases other than haemochromatosis - pathogenic, prognostic, and therapeutic implications.

Authors:
Albert J Czaja

Aliment Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

Background: Disturbances in iron regulation have been described in diverse chronic liver diseases other than hereditary haemochromatosis, and iron toxicity may worsen liver injury and outcome.

Aims: To describe manifestations and consequences of iron dysregulation in chronic liver diseases apart from hereditary haemochromatosis and to encourage investigations that clarify pathogenic mechanisms, define risk thresholds for iron toxicity, and direct management METHODS: English abstracts were identified in PubMed by multiple search terms. Full length articles were selected for review, and secondary and tertiary bibliographies were developed. Read More

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http://dx.doi.org/10.1111/apt.15173DOI Listing
February 2019

Molecular drivers of non-alcoholic steatohepatitis are sustained in mild-to-late fibrosis progression in a guinea pig model.

Mol Genet Genomics 2019 Feb 13. Epub 2019 Feb 13.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871, Frederiksberg C, Denmark.

Hepatic fibrosis increases mortality in humans with non-alcoholic steatohepatitis (NASH), but it remains unclear how fibrosis stage and progression affect the pathogenic mechanisms of NASH. This study investigates the transcriptional regulation and the impact of fibrosis stage, of pathways relating to hepatic lipid and cholesterol homeostasis, inflammation and fibrosis using RT-qPCR in the guinea pig NASH model. Animals were fed a chow (4% fat), a high-fat (20% fat, 0. Read More

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http://dx.doi.org/10.1007/s00438-019-01537-zDOI Listing
February 2019

The efficacy of saxagliptin in T2DM patients with non-alcoholic fatty liver disease: preliminary data.

Rev Assoc Med Bras (1992) 2019 Jan;65(1):33-37

Department of Ultrasonography, Qilu Hospital of Shandong University (Qingdao), Shandong Province, China.

Objective: To investigate the clinical efficacy and the possible mechanisms of saxagliptin in the treatment of type 2 diabetes mellitus (T2DM) combined with non-alcoholic fatty liver disease (NAFLD).

Methods: A total of 95 T2DM and NAFLD patients were randomly divided into group A (saxagliptin group), group B (glimepiride group), and group C (glimepiride combined with polyene phosphatidylcholine group).

Results: After intervention treatment for 24 w, body mass index (BMI), waist-to-hip ratio (WHR), glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), fasting insulin (FINS), homeostatic model assessment of insulin resistance (HOMA-IR), interleukin-6 (IL-6), triglyceride (TG), total cholesterol (TC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (γ-GT), and quantitative detection of liver steatosis of study subjects were observed, the action of liver steatosis in subjects of groups A and C were significantly different from those of group B; however, there were no differences between groups A and C. Read More

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http://dx.doi.org/10.1590/1806-9282.65.1.33DOI Listing
January 2019
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Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat.

Pharm Biol 2019 Dec;57(1):98-104

a Department of Anesthesiology , Qilu Hospital of Shandong University , Shandong , Jinan , People's Republic of China.

Context: Cassia semen (Cs), a seed of Cassia obtusifolia L. (Leguminosae), is a popular functional beverage. Previous studies reported that Cs displayed antioxidant, antifungal and strong liver protective effects. Read More

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http://dx.doi.org/10.1080/13880209.2019.1568509DOI Listing
December 2019

Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population.

J Dig Dis 2019 Feb 12. Epub 2019 Feb 12.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Aim: The early screening of non-alcoholic fatty liver disease (NAFLD) is of great significance for early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators of metabolic disease, including NAFLD. The aim of this study was to examine the association of serum miR-29a-c with NAFLD in a Chinese population. Read More

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http://dx.doi.org/10.1111/1751-2980.12716DOI Listing
February 2019

Mauriac Syndrome: A Rare Complication of Type 1 Diabetes Mellitus.

Eur J Case Rep Intern Med 2018 27;5(12):000969. Epub 2018 Dec 27.

Department of Internal Medicine, Centro Hospitalar Universitário de São João, E.P.E., Porto, Portugal.

Mauriac syndrome, first described in 1930, is typically diagnosed in young patients with poorly controlled type 1 diabetes mellitus and growth retardation, delayed puberty, Cushingoid features, hypercholesterolaemia and hepatomegaly. However, the sole presenting feature of Mauriac syndrome can be hepatic glycogenosis in both adults and children. The mainstay of treatment for hepatic glycogenosis is strict control of glucose levels, with an excellent prognosis with improved glycaemic control. Read More

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http://dx.doi.org/10.12890/2018_000969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346977PMC
December 2018

Non-alcoholic fatty liver disease and cerebral small vessel disease in Korean cognitively normal individuals.

Sci Rep 2019 Feb 12;9(1):1814. Epub 2019 Feb 12.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.

We aimed to investigate the association between nonalcoholic fatty liver disease (NAFLD) and cerebral small vessel disease (CSVD) burden, especially according to the NAFLD severity. A total of 1,260 participants were included. The CSVD burden was assessed with white matter hyperintensities (WMH), lacunes, and microbleeds (MBs) on brain MRI. Read More

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http://dx.doi.org/10.1038/s41598-018-38357-xDOI Listing
February 2019

Emerging awareness on the importance of skeletal muscle in liver diseases: time to dig deeper into mechanisms!

Clin Sci (Lond) 2019 Feb 12;133(3):465-481. Epub 2019 Feb 12.

Laboratory of Hepato-Gastroenterology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain (UCLouvain), Brussels, Belgium

Skeletal muscle is a tissue that represents 30-40% of total body mass in healthy humans and contains up to 75% of total body proteins. It is thus the largest organ in non-obese subjects. The past few years have seen increasing awareness of the prognostic value of appreciating changes in skeletal muscle compartment in various chronic diseases. Read More

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http://dx.doi.org/10.1042/CS20180421DOI Listing
February 2019

Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway.

Eur J Pharmacol 2019 Feb 9. Epub 2019 Feb 9.

Institute for Liver Diseases of Anhui Medical University, School of pharmacy, Anhui medical university, Hefei, 230032, China; Key Laboratory of anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, 230032, China. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease which affects millions of people worldwide. Acetaminophen (APAP) overdose is the leading cause of acute liver failure. In this study, APAP (50, 100, 200mg/kg) were employed on mice fed with a high-fat diet, and APAP (2, 4, 8mM) were cultured with L02 cells in the presence of alcohol and oleic acid. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.005DOI Listing
February 2019

Hepatic IRF6 alleviates liver steatosis and metabolic disorder by transcriptionally suppressing PPARγ.

Hepatology 2019 Feb 12. Epub 2019 Feb 12.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.

Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and growing unmet therapeutic need has inspired numerous studies in the field. Integrating the published genomic data available in the Gene Expression Omnibus with NAFLD samples from rodents, we discovered that interferon regulatory factor 6 (IRF6) is significantly suppressed in high-fat diet (HFD)-induced fatty liver. Read More

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http://dx.doi.org/10.1002/hep.30559DOI Listing
February 2019
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11.055 Impact Factor

Comparative study of overweight and obese patients with nonalcoholic fatty liver disease.

Rev Esp Enferm Dig 2019 Feb 11;111. Epub 2019 Feb 11.

Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid.

Background And Aims: non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in the western world. Although NAFLD prevalence is higher in patients with a BMI > 25 kg /m2, it is unclear if there are differences between overweight and obese patients. The associated biochemical, dietary and genetic parameters were compared between overweight and obese patients with NAFLD. Read More

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http://dx.doi.org/10.17235/reed.2019.5926/2018DOI Listing
February 2019

Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic Fatty Liver Disease: Recent Updates.

Int J Biol Sci 2019 1;15(2):265-276. Epub 2019 Jan 1.

Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310051, China.

Non-alcoholic fatty liver disease (NAFLD) is an acquired metabolic disease characterized by triglycerides (TGs) deposition in liver induced by other factors rather than alcohol consumption. NAFLD significantly contributes to liver diseases in children and adults. NAFLD pathogenesis is associated with age, gender, race and ethnicity. Read More

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http://dx.doi.org/10.7150/ijbs.30121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367556PMC
January 2019
4.509 Impact Factor

Non-alcoholic fatty liver disease is associated with low-grade albuminuria in men without diabetes mellitus.

Int J Med Sci 2019 1;16(2):285-291. Epub 2019 Jan 1.

Division of Nephrology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Republic of Korea.

Non-alcoholic fatty liver disease (NAFLD) is associated with the dysregulation of multiple metabolic and inflammatory pathways. These can lead to extrahepatic disorders involving the kidney, a vulnerable organ responsible for extra-renal complications. Evaluating the association between NAFLD and low-grade albuminuria as a renal complication would be helpful to better understand the pathophysiology and extra-hepatic complications of NAFLD. Read More

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http://dx.doi.org/10.7150/ijms.28264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367539PMC
January 2019

Bone Health in Patients With Liver Diseases.

J Clin Densitom 2019 Jan 18. Epub 2019 Jan 18.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA. Electronic address:

Osteoporosis is the most common bone disease in chronic liver disease (CLD) resulting in frequent fractures and leading to significant morbidity in this population. In addition to patients with cirrhosis and chronic cholestasis, patients with CLD from other etiologies may be affected in the absence of cirrhosis. The mechanism of osteoporosis in CLD varies according to etiology, but in cirrhosis and cholestatic liver disease it is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Read More

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http://dx.doi.org/10.1016/j.jocd.2019.01.004DOI Listing
January 2019

Regular exposure to non-burning ultraviolet radiation reduces signs of non-alcoholic fatty liver disease in mature adult mice fed a high fat diet: results of a pilot study.

BMC Res Notes 2019 Feb 11;12(1):78. Epub 2019 Feb 11.

Telethon Kids Institute, University of Western Australia, West Perth, PO Box 855, Perth, WA, 6872, Australia.

Objective: Obesity often emerges in middle age, increasing risk for metabolic disorders. Our previous preclinical experiments identified that chronic exposure to non-burning ultraviolet radiation, like that achieved through sun exposure, prevented weight gain and signs of metabolic dysfunction in young adult mice fed a high fat diet. Our objective was to perform a pilot study to estimate the effect size of ongoing exposure to sub-erythemal (non-burning, low dose) UVB (1 kJ/m) radiation on measures of adiposity, food intake and physical activity in 'mature' adult C57Bl/6J male mice fed a high fat diet for 12 weeks. Read More

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http://dx.doi.org/10.1186/s13104-019-4112-8DOI Listing
February 2019

Hepatic sonic hedgehog protein expression measured by computer assisted morphometry significantly correlates with features of non-alcoholic steatohepatitis.

BMC Gastroenterol 2019 Feb 11;19(1):27. Epub 2019 Feb 11.

Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Virginia, USA.

Background: Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnosis of NASH. This pilot study was designed to confirm that staining for SHH is useful in NASH diagnosis and determine whether quantification of staining by computer assisted morphometry (CAM) can be used to assess severity of ballooning degeneration. Read More

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http://dx.doi.org/10.1186/s12876-019-0951-yDOI Listing
February 2019

American ancestry is a risk factor for suspected non-alcoholic fatty liver disease in Hispanic/Latino adults.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Division of Hepatology, Loyola University Medical Center, Maywood IL.

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) disproportionally affects Hispanic/Latino populations. However, the magnitude varies among Hispanic/Latino ethnic groups. We investigated the mechanisms of these disparities. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.007DOI Listing
February 2019
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Metabolic effects and safety of Roux-en-Y gastric bypass surgery versus conventional medication in obese Chinese patients with type 2 diabetes.

Diabetes Metab Res Rev 2019 Feb 10:e3138. Epub 2019 Feb 10.

Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.

Aim: To assess metabolic effects and safety of Roux-en-Y gastric bypass (RYGB) versus conventional medication (CM) in obese Chinese patients with type 2 diabetes (T2DM).

Methods: This retrospective cohort study included 40 patients who underwent RYGB (mean age 44.1 years, body mass index (BMI) 33. Read More

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http://dx.doi.org/10.1002/dmrr.3138DOI Listing
February 2019

Permethrin and ivermectin modulate lipid metabolism in steatosis-induced HepG2 hepatocyte.

Food Chem Toxicol 2019 Feb 6. Epub 2019 Feb 6.

Department of Food Science, University of Massachusetts, Amherst, USA. Electronic address:

Recent studies have reported the positive association between exposure to insecticides and increased risk of obesity and type 2 diabetes, which are closely associated with non-alcoholic fatty liver disease (NAFLD). However, it is not known if insecticide exposure can contribute to NAFLD. Thus, the goal of the current study was to determine if insecticide exposures can exacerbate the physiological conditions of NAFLD by modulating hepatic lipid metabolism. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.005DOI Listing
February 2019
1 Read

Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation.

J Lipid Res 2019 Feb 8. Epub 2019 Feb 8.

University of Alberta, Canada;

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. TG accumulation in liver is a hallmark of NAFLD. Metabolic studies have confirmed that increased hepatic de novo lipogenesis in humans contributes to fat accumulation in the liver and to NAFLD progression. Read More

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http://dx.doi.org/10.1194/jlr.M092544DOI Listing
February 2019
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Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Feb 5;1864(5):662-676. Epub 2019 Feb 5.

Department of Internal Medicine IV, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address:

A defect of hepatic remodeling of phospholipids (PL) is seen in non-alcoholic fatty liver disease and steatohepatitis (NASH) indicating pivotal role of PL metabolism in this disease. The deletion of group VIA calcium-independent phospholipase A2 (iPla2β) protects ob/ob mice from hepatic steatosis (BBAlip 1861, 2016, 440-461), however its role in high-fat diet (HFD)-induced NASH is still elusive. Here, wild-type and iPla2β-null mice were subjected to chronic feeding with HFD for 6 months. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.01.012DOI Listing
February 2019
2 Reads

iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Feb 5. Epub 2019 Feb 5.

Department of Internal Medicine IV, University of Heidelberg Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address:

Group VIA calcium-independent phospholipase A2 (iPla2β) is among modifier genes of non-alcoholic fatty liver disease which leads to non-alcoholic steatohepatitis (NASH). Consistently, iPla2β deletion protects hepatic steatosis and obesity in genetic ob/ob and obese mice chronically fed with high-fat diet by replenishing the loss of hepatic phospholipids (PL). As mouse feeding with methionine- and choline-deficient (MCD) diet is a model of lean NASH, we tested whether iPla2β-null mice could still be protected since PL syntheses are disturbed. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.02.003DOI Listing
February 2019
2 Reads

Epidermal growth factor receptor inhibition attenuates non-alcoholic fatty liver disease in diet-induced obese mice.

PLoS One 2019 8;14(2):e0210828. Epub 2019 Feb 8.

Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea.

Non-alcoholic fatty liver disease (NAFLD) is one of the main causes of chronic liver disease. NAFLD begins with excessive lipid accumulation in the liver and progresses to nonalcoholic steatohepatitis (NASH) and cirrhosis. NAFLD is closely linked to dysregulated hepatic lipid metabolism. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210828PLOS
February 2019

Understanding susceptibility and targeting treatment in non-alcoholic fatty liver disease in children; moving the fulcrum.

Authors:
Emer Fitzpatrick

Proc Nutr Soc 2019 Feb 8:1-10. Epub 2019 Feb 8.

Paediatric Liver Centre, King's College London, Faculty of Life Sciences and Medicine at King's College Hospital,London,UK.

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of paediatric liver disease, affecting 10% of school-aged children and 44-70% of obese children and young people (CYP) in the western world. Encompassing a spectrum from simple steatosis to steatohepatitis and progressive fibrosis, the disease is rapidly becoming the most common indication for liver transplantation. The molecular pathogenesis of NAFLD remains only partially understood. Read More

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http://dx.doi.org/10.1017/S0029665118002914DOI Listing
February 2019
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Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation.

Eur J Sport Sci 2019 Feb 8:1-10. Epub 2019 Feb 8.

d Department of Exercise Physiology , Islamic Azad University, Central Tehran Branch , Tehran , Iran.

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder which is associated with accumulation of fats in the liver. It causes a wide variety of pathological effects such as non-alcoholic steatohepatitis (NASH) and cirrhosis, insulin resistance, obesity, hypertension, dyslipidaemia, diabetes and cardiovascular disease. The molecular mechanisms that cause the initiation and progression of NAFLD are not fully understood. Read More

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https://www.tandfonline.com/doi/full/10.1080/17461391.2019.1
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http://dx.doi.org/10.1080/17461391.2019.1571114DOI Listing
February 2019
4 Reads

Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps.

Atherosclerosis 2019 Jan 30;282:110-120. Epub 2019 Jan 30.

Department of Molecular and Clinical Medicine Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and includes a spectrum of abnormalities ranging from steatosis to cirrhosis. In this review, we address recent evidence and limitations of studies that evaluated the association of NAFLD with atherosclerotic cardiovascular disease. NAFLD is considered an ectopic fat deposit associated with metabolic (insulin resistance, hyperglycemia and dyslipidemia), inflammatory, coagulation and blood pressure disturbances. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.029DOI Listing
January 2019
1 Read

Obesity in South Asia: Phenotype, Morbidities, and Mitigation.

Curr Obes Rep 2019 Feb 7. Epub 2019 Feb 7.

Metabolic Diseases and Allied Specialties, Fortis-C-DOC Hospital for Diabetes, B-16, Chirag Enclave, New Delhi, India.

Purpose Of Review: Obesity has increased in South Asian countries that are still grappling with undernutrition. In this review, we highlight the characteristics of obesity, its relation to morbidities, and its management in South Asians. A literature search was conducted using relevant search engines and based on key words focusing on obesity in South Asians. Read More

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http://dx.doi.org/10.1007/s13679-019-0328-0DOI Listing
February 2019
2 Reads

Association of TM6SF2 rs58542926 gene polymorphism with the risk of non-alcoholic fatty liver disease and colorectal adenoma in Chinese Han population.

BMC Biochem 2019 Feb 6;20(1). Epub 2019 Feb 6.

Medical College of Qingdao University, Qingdao, 266071, China.

Background: Genetic factors affect the risk of non-alcoholic fatty liver disease (NAFLD) and colorectal adenoma (CRA) importantly. Transmembrane protein 6 superfamily member 2 (TM6SF2) rs58542926 is a significant genetic susceptibility site for NAFLD. The relationships of TM6SF2 rs58542926 with the risk of NAFLD and CRA in Chinese Han population were unclear. Read More

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http://dx.doi.org/10.1186/s12858-019-0106-3DOI Listing
February 2019
2 Reads
1.438 Impact Factor

Impact of Lipotoxicity on Tissue "Cross Talk" and Metabolic Regulation.

Physiology (Bethesda) 2019 Mar;34(2):134-149

Department of Physiology, The University of Melbourne , Melbourne, Victoria , Australia.

Obesity-associated comorbidities include non-alcoholic fatty liver disease, Type 2 diabetes, and cardiovascular disease. These diseases are associated with accumulation of lipids in non-adipose tissues, which can impact many intracellular cellular signaling pathways and functions that have been broadly defined as "lipotoxic." This review moves beyond understanding intracellular lipotoxic outcomes and outlines the consequences of lipotoxicity on protein secretion and inter-tissue "cross talk," and the impact this exerts on systemic metabolism. Read More

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http://dx.doi.org/10.1152/physiol.00037.2018DOI Listing
March 2019
1 Read

Preparation and Evaluation of Functional Foods for Prevention of Non-alcoholic Fatty Liver Disease.

Pak J Biol Sci 2018 Jan;21(9):454-462

Background And Objective: Non-alcoholic fatty liver disease (NAFLD) is a public health problem presenting one of the most important common forms of liver diseases worldwide. This study was carried out to investigate the protective effect of two functional foods in form of bread containing purslane seeds meal and garden cress seeds against NAFLD.

Materials And Methods: High fat and high cholesterol diet were used for induction of NAFLD in rats for 6 weeks. Read More

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http://dx.doi.org/10.3923/pjbs.2018.454.462DOI Listing
January 2018

Randomized trial comparing effects of weight loss by liraglutide with lifestyle modification in non-alcoholic fatty liver disease.

Liver Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Aims: We compared the effects of weight loss induced with the glucagon-like peptide-1 agonist liraglutide, with that of lifestyle modification, followed by weight maintenance after discontinuing intervention, in obese adults with NAFLD.

Methods: Thirty obese (mean age 40.7 ± 9. Read More

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http://dx.doi.org/10.1111/liv.14065DOI Listing
February 2019
1 Read

MicroRNA-30b Regulates Insulin Sensitivity by Targeting SERCA2b in Non-alcoholic Fatty Liver Disease.

Liver Int 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, China.

Background & Aims: Insulin resistance is strongly associated with nonalcoholic fatty liver disease, a chronic, obesity-related liver disease. Increased endoplasmic reticulum stress plays an important role in the development of insulin resistance. In this study, we investigated the roles of miRNAs in regulating ER stress in the liver of rats with obesity. Read More

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http://dx.doi.org/10.1111/liv.14067DOI Listing
February 2019
2 Reads
4.850 Impact Factor

Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (L-serine activates SIRT1 in C2C12 myotubes).

Cell Biol Toxicol 2019 Feb 5. Epub 2019 Feb 5.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.

Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, and the function is linked to cellular metabolism including mitochondrial biogenesis. Hepatic L-serine concentration is decreased significantly in fatty liver disease. We reported that the supplementation of the amino acid ameliorated the alcoholic fatty liver by enhancing L-serine-dependent homocysteine metabolism. Read More

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http://dx.doi.org/10.1007/s10565-019-09463-xDOI Listing
February 2019
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Novel Interplay Between Sonic Hedgehog and Transforming Growth Factor-β1 in Human Nonalcoholic Steatohepatitis.

Appl Immunohistochem Mol Morphol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology.

Nonalcoholic steatohepatitis (NASH) has the potential to progress to fibrosis, cirrhosis, and hepatocellular carcinoma. Upregulation of sonic hedgehog (Shh) has been documented in development of NASH through sustained cell stress. At the same time, transforming growth factor-β1 (TGF-β1), which is a central element in fibrogenic reactions in various diseases and sites, has been reported to be associated with hepatic inflammation and fibrotic reaction. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000724DOI Listing
February 2019
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Intestinal permeability in physiological and pathological conditions: major determinants and assessment modalities.

Eur Rev Med Pharmacol Sci 2019 Jan;23(2):795-810

Area Gastroenterologia ed Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Intestinal permeability is the property that allows solute and fluid exchange between intestinal lumen and intestinal mucosa. Many factors could have major impact on its regulation, including gut microbiota, mucus layer, epithelial cell integrity, epithelial junction, immune responses, intestinal vasculature, and intestinal motility. Any change among these factors could have an impact on intestinal homeostasis and gut permeability. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16894DOI Listing
January 2019
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Review article: shared disease mechanisms between non-alcoholic fatty liver disease and metabolic syndrome - translating knowledge from systems biology to the bedside.

Aliment Pharmacol Ther 2019 Mar 4;49(5):516-527. Epub 2019 Feb 4.

School of Medicine, Institute of Medical Research A. Lanari, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Background: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. Characterised by abnormal fat accumulation in the liver, NAFLD presents high degree of comorbidity with disorders of the metabolic syndrome, including type 2 diabetes, obesity and cardiovascular disease. These comorbidities have strong negative impact on the natural course of NAFLD and vice versa, whereby the presence of NAFLD substantially modifies the course and prognosis of metabolic syndrome-associated diseases. Read More

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http://dx.doi.org/10.1111/apt.15163DOI Listing
March 2019
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Preventive Effect of Citrus aurantium Peel Extract on High-Fat Diet-Induced Non-alcoholic Fatty Liver in Mice.

Biol Pharm Bull 2019 ;42(2):255-260

College of Veterinary Medicine and Institute of Veterinary Science, Chungnam National University.

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation, which is the most common form of chronic liver disease. Multiple clinical studies using natural compounds such as flavonoids have been conducted to treat NAFLD. In the present study, the pharmacological effect of Citrus aurantium L. Read More

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http://dx.doi.org/10.1248/bpb.b18-00702DOI Listing
January 2019

ESPEN guideline on clinical nutrition in liver disease.

Clin Nutr 2019 Jan 16. Epub 2019 Jan 16.

Department for Clinical Nutrition, University of Hohenheim, Stuttgart, Germany.

This update of evidence-based guidelines (GL) aims to translate current evidence and expert opinion into recommendations for multidisciplinary teams responsible for the optimal nutritional and metabolic management of adult patients with liver disease. The GL was commissioned and financially supported by ESPEN. Members of the guideline group were selected by ESPEN. Read More

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http://dx.doi.org/10.1016/j.clnu.2018.12.022DOI Listing
January 2019
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The effects of perfluorooctanoate on high fat diet induced non-alcoholic fatty liver disease in mice.

Toxicology 2019 Jan 31;416:1-14. Epub 2019 Jan 31.

Laboratory of Investigative Toxicology and Pathology, Department of Environmental and Occupational Health, Indiana University, Bloomington, IN, 47405, United States. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is affecting up to one-third of the general population in western countries. While the major cause of NAFLD is related to an unhealthy lifestyle, recent evidence has shown a role of chemical exposure in the induction and progression of NAFLD. Perfluorooctanoate (PFOA) is a ubiquitous environmental contaminant that exerts its hepatotoxicity mainly through the activation of peroxisome proliferator-activated receptor α (PPARα). Read More

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http://dx.doi.org/10.1016/j.tox.2019.01.017DOI Listing
January 2019

LncRNA MEG3 functions as a ceRNA in regulating hepatic lipogenesis by competitively binding to miR-21 with LRP6.

Metabolism 2019 Jan 31. Epub 2019 Jan 31.

Emergency Department, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410013, China. Electronic address:

Background: Hepatic lipogenesis dysregulation is essential for the development of non-alcoholic fatty liver disease (NAFLD). Emerging evidence indicates the importance of the involvement of long non-coding RNAs (LncRNAs) in lipogenesis. However, the specific mechanism underlying this process is not clear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193003
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http://dx.doi.org/10.1016/j.metabol.2019.01.018DOI Listing
January 2019
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No association between fruits or vegetables and non-alcoholic fatty liver disease in middle-aged men and women.

Nutrition 2018 Oct 23;61:119-124. Epub 2018 Oct 23.

Department of Nutrition and Food Science, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan; The Institute for Human Life Innovation, Ochanomizu University, Tokyo, Japan. Electronic address:

Objective: It has been hypothesized that fruit and vegetable intake is inversely associated with non-alcoholic fatty liver (NAFLD). However, some studies have speculated that fruit intake might be positively associated with NAFLD owing to the fructose content of the fruit. This might cause consumers to hesitate consuming fruit. Read More

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http://dx.doi.org/10.1016/j.nut.2018.10.016DOI Listing
October 2018
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Mitochondrial oxysterol biosynthetic pathway gives evidence for CYP7B1 as controller of regulatory oxysterols.

J Steroid Biochem Mol Biol 2019 Jan 30;189:36-47. Epub 2019 Jan 30.

Department of Internal Medicine, Virginia Commonwealth University, United States; Department of Veterans Affairs, Richmond, VA, United States.

The aim of this paper was to more completely study the mitochondrial CYP27A1 initiated acidic pathway of cholesterol metabolism. The mitochondrial CYP27A1 initiated pathway of cholesterol metabolism (acidic pathway) is known to synthesize two well-described vital regulators of cholesterol/lipid homeostasis, (25R)-26-hydroxycholesterol (26HC) and 25-hydroxycholesterol (25HC). Both 26HC and 25HC have been shown to be subsequently 7α-hydroxylated by Cyp7b1; reducing their regulatory abilities and furthering their metabolism to chenodeoxycholic acid (CDCA). Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.01.011DOI Listing
January 2019

Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.

Redox Biol 2019 Feb 23;21:101120. Epub 2019 Jan 23.

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Obesity-related non-alcoholic fatty liver disease (NAFLD) is connected with mitochondrial stress and hepatocyte apoptosis. Parkin-related mitophagy sustains mitochondrial homeostasis and hepatocyte viability. However, the contribution and regulatory mechanisms of Parkin-related mitophagy in NAFLD are incompletely understood. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357900PMC
February 2019
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Dietary patterns and non-alcoholic fatty liver disease in a Greek case-control study.

Nutrition 2018 Oct 29;61:105-110. Epub 2018 Oct 29.

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.

Objective: The aim of this study was to test the hypothesis that posteriori-derived dietary patterns of a Greek sample are associated with the odds for non-alcoholic fatty liver disease (NAFLD) and common NAFLD-related biomarkers.

Methods: We recruited 351 individuals (134 NAFLD patients, 217 controls). NAFLD was diagnosed with abdominal ultrasound. Read More

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http://dx.doi.org/10.1016/j.nut.2018.10.032DOI Listing
October 2018
1 Read