15,156 results match your criteria Alcohol-Related Psychosis


Psychosocial interventions to reduce alcohol consumption in concurrent problem alcohol and illicit drug users.

Cochrane Database Syst Rev 2018 Dec 5;12:CD009269. Epub 2018 Dec 5.

BC Centre on Substance Use, BC Centre for Excellence in HIV/AIDS, 611 Powell Street, Vancouver, BC, Canada, V6A 1H2.

Background: Problem alcohol use is common among people who use illicit drugs (PWID) and is associated with adverse health outcomes. It is also an important factor contributing to a poor prognosis among drug users with hepatitis C virus (HCV) as it impacts on progression to hepatic cirrhosis or opioid overdose in PWID.

Objectives: To assess the effectiveness of psychosocial interventions to reduce alcohol consumption in PWID (users of opioids and stimulants). Read More

View Article
December 2018
5 Reads

Licence to swill: James Bond's drinking over six decades.

Med J Aust 2018 Dec;209(11):495-500

Oxford University, Oxford, United Kingdom.

Objectives: To describe the patterns of alcohol use in James Bond movies over six decades.

Design: Film content analysis.

Setting: Wide range of international locations in 24 James Bond movies (Eon Productions series, 1962-2015). Read More

View Article
December 2018
1 Read

Re-examining the relationship between alcohol consumption and coronary heart disease with a new lens.

Prev Med 2018 Nov 30. Epub 2018 Nov 30.

Epidemiology and Biometry Branch, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, United States.

Moderate alcohol consumption has been related to lower risk of coronary heart disease (CHD) in the literature. To examine whether alcohol drinking during the past 12 months and heaviest drinking period were differentially associated with the risk of CHD, we designed a case-control study using a population-based health survey of U.S. Read More

View Article
November 2018

Recent trends in US mortality in early and middle adulthood: racial/ethnic disparities in inter-cohort patterns.

Int J Epidemiol 2018 Dec 1. Epub 2018 Dec 1.

Department of Sociology and Social Science Research Institute, Duke University, Durham, NC, USA.

Background: A striking increase in the all-cause mortality of US middle-aged non-Hispanic Whites in the past two decades has been documented by previous studies. The inter-cohort patterns in US mortality, as well as their racial/ethnic disparities, are still unclear.

Methods: Using official mortality data, we study US annual mortality rates for ages 25-54 from 1990 to 2016 by gender and race/ethnicity. Read More

View Article
December 2018

A randomized control trial of a deviance regulation theory intervention to increase alcohol protective strategies.

J Consult Clin Psychol 2018 Dec;86(12):1061-1075

Department of Psychology.

Objective: Normative feedback remains an effective approach to reducing alcohol use among college students. However, this approach is difficult to extend to protective behavioral strategies (PBS), which are proximal to alcohol-related problems. Deviance regulation theory (DRT) is a social psychology theory that posits individuals engage in behaviors to standout out in positive ways or avoid standing out in negative ways. Read More

View Article
December 2018

Relapse prevention in abstinent alcoholics by cognitive bias modification: Clinical effects of combining approach bias modification and attention bias modification.

J Consult Clin Psychol 2018 Dec;86(12):1005-1016

Salus Clinic Lindow.

Objective: Alcohol-dependent patients show attentional and approach biases for alcohol-related stimuli. Computerized cognitive bias modification (CBM) programs aim to retrain these biases and reduce relapse rates as add-ons to treatment. Retraining of alcohol-approach tendencies has already yielded significant reductions of relapse rates in previous studies, and retraining of biased attention toward alcohol is promising approach. Read More

View Article
December 2018

Increased Interleukin-23 Receptor (IL-23R) Expression is Associated with Disease Severity in Acute-on-Chronic Liver Failure.

Liver Int 2018 Dec 2. Epub 2018 Dec 2.

Dept. of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: Th17 cells mediated immune response is important in chronic hepatitis B (CHB) infection and inflammation associated diseases, however, little is known about their immunopathogenic role in acute-on-chronic liver failure (ACLF). Interleukin-23 receptor (IL-23R) is essential for the generation of pathogenic Th17 cells, therefore, we aimed to evaluate IL-23R expression and its correlation with disease severity in ACLF.

Methods: Forty two patients with ACLF (HBV and alcohol-related), thirty two with CHB and twenty healthy controls (HC) were studied. Read More

View Article
December 2018

Pilot Study of a Brief WeChat Intervention in China to Increase Students' Willingness to Assist a Flushing Student to Reduce Alcohol Use.

J Prev Med Public Health 2018 Nov 7;51(6):320-325. Epub 2018 Nov 7.

Nebraska Prevention Center for Alcohol and Drug Abuse, Department of Educational Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.

Objectives: This pilot study tested the effectiveness of a brief alcohol-related intervention delivered by the social media app WeChat to teach about ethanol-induced facial flushing and increase the willingness of students who see another student flushing to suggest that he or she should reduce or stop drinking. In the context of Chinese drinking culture, it is sometimes socially difficult to refuse a drink, even when experiencing physical discomfort, such as flushing.

Methods: Classrooms of students in a medical university in China were randomly assigned to the intervention or control group. Read More

View Article
November 2018
3 Reads

Hello Sunday Morning: Strategies used to support temporary alcohol abstinence through participation in an online health promotion program.

Health Promot J Austr 2018 Dec 28;29(3):321-327. Epub 2017 Dec 28.

Victorian Responsible Gambling Foundation, Melbourne, Australia.

Issue Addressed: Hello Sunday Morning (HSM) is an online program that encourages people to commit to a period of non-drinking and blog about their experiences. Among a sample of Victorian HSM users, we aimed to explore the barriers faced and the strategies adopted to maximise potential for achieving temporary abstinence.

Methods: A content analysis of blog data from 154 HSM users (a total of 2844 blog posts) was undertaken by three researchers. Read More

View Article
December 2018
2 Reads

Alcohol Outlet Density and Area-Level Heavy Drinking Are Independent Risk Factors for Higher Alcohol-Related Complaints.

J Urban Health 2018 Dec 3. Epub 2018 Dec 3.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

Alcohol outlet density has well-documented associations with social and health indicators such as crime and injury. However, significantly less is known about the relationships among alcohol-related complaints. Bayesian hierarchical Poisson regression with spatial autocorrelation was used to model the association between on- and off-premises alcohol outlet density and area-level prevalence of current drinkers and heavy drinking, and graffiti density-an indicator of physical disorder-in association with calls from civilians reporting illegal use, alcohol sales, and other alcohol-related activities (hereafter alcohol-related complaints). Read More

View Article
December 2018

Alcohol-related attentional bias in a gaze contingency task: Comparing appetitive and non-appetitive cues.

Addict Behav 2018 Nov 24;90:312-317. Epub 2018 Nov 24.

Edge Hill University, St Helens Rd, Ormskirk L39 4QP, UK.

Background: Non-problem drinkers attend automatically to alcohol-related cues compared to non-alcohol related cues on tests of inhibitory control. Moreover, attentional bias for alcohol-related cues varies between problem and non-problem drinkers.

Aim: To examine attentional bias towards alcoholic and non-alcoholic appetitive cues between problem and non-problem drinkers. Read More

View Article
November 2018
1 Read

Stigma management intervention to improve antiretroviral therapy adherence: Phase-I test of concept trial, Cape Town South Africa.

Glob Public Health 2018 Nov 30:1-16. Epub 2018 Nov 30.

a Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut , Storrs, CT, USA.

Combination antiretroviral therapy (cART) has transformed HIV infection from a universally fatal disease to a medically manageable chronic illness. We conducted a Phase-I test of concept intervention trial to examine feasibility and potential efficacy of behavioural self-regulation counselling designed to improve care retention and cART adherence. The intervention was culturally adapted from client-centered evidence-based interventions that are grounded in behavioural self-regulation theory and available in the US. Read More

View Article
November 2018

Body mass index and craving predict 24-month hospital readmissions of alcohol-dependent in-patients following withdrawal.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Nov 26. Epub 2018 Nov 26.

Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany.

Objective: Addictive alcohol drinking, craving, and overeating share common etiopathological mechanisms. We investigated whether body mass index (BMI) and craving predict outcome of alcohol-dependent in-patients.

Method: The prospective study included 101 male and 72 female early-abstinent alcohol-dependent in-patients. Read More

View Article
November 2018

Harms from a partner's drinking: an international study on adverse effects and reduced quality of life for women.

Am J Drug Alcohol Abuse 2018 Nov 29:1-9. Epub 2018 Nov 29.

a Centre for Alcohol Policy Research , La Trobe University , Bundoora , Australia.

Background: Partners of heavy drinking individuals can be detrimentally affected as a result of their partner's drinking.

Objectives: The aim of this study was to identify the proportion of heterosexual intimate partner relationships with a heavy drinking male that resulted in reported alcohol-related harm and to investigate the impact of this on well-being in 9 countries.

Methods: This study used survey data from the Gender and Alcohol's Harm to Others (GENAHTO) Project on Alcohol's Harm to Others in 9 countries (10,613 female respondents, 7,091 with intimate live-in partners). Read More

View Article
November 2018

NCEPOD and alcohol-related liver disease, what are the views of those who deliver the service? A survey of consultants and trainees in North Eastern England.

J R Coll Physicians Edinb 2018 Dec;48(4):293-298

Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust; Newcastle upon Tyne, UK.

Background: National Confidential Enquiry into Patient Outcome and Death (NCEPOD) 'Measuring the Units' (June 2013) identified significant organisational and attitudinal deficits in hospital care of patients with alcohol-related liver disease (ARLD), care being recognised as good in less than 50% of patients.

Method: We surveyed over 700 consultants and trainees in acute medical and intensive therapy specialties to examine their perceptions of the NCEPOD findings.

Results: A total of 178 responded. Read More

View Article
December 2018

Tackling the epidemic: the NCEPOD report on alcohol-related liver disease and the Lancet Commission on Liver Disease.

Authors:
C Kiat S O'Mahony

J R Coll Physicians Edinb 2018 Dec;48(4):291-292

Department of Gastroenterology and Hepatology, Cork University Hospital, Cork, Ireland.

View Article
December 2018

Baclofen for alcohol use disorder.

Cochrane Database Syst Rev 2018 Nov 26;11:CD012557. Epub 2018 Nov 26.

Department of Epidemiology, Lazio Regional Health Service, Via Cristoforo Colombo, 112, Rome, Italy, 00154.

Background: Alcohol use disorder (AUD) and alcohol-related impairments belong to the most widespread psychiatric disorders leading to specific psychophysical, affective and cognitive symptoms and consequences for psychosocial well-being and health. Alcohol consumption is increasingly becoming a problem in many developing regions and AUD prevalence is estimated at 4.1% worldwide, with highest prevalence in European countries (7. Read More

View Article
November 2018

Rates and Impact of Adherence to Recommended Care for Unhealthy Alcohol Use.

J Gen Intern Med 2018 Nov 27. Epub 2018 Nov 27.

RAND Corporation, Santa Monica, CA, USA.

Background: Unhealthy alcohol use is a major worldwide health problem. Yet few studies have assessed provider adherence to the alcohol-related care recommended in clinical practice guidelines, nor links between adherence to recommended care and outcomes.

Objectives: To describe quality of care for unhealthy alcohol use and its impacts on drinking behavior RESEARCH DESIGN: Prospective observational cohort study of quality of alcohol care for the population of patients screening positive for unhealthy alcohol use in a large Veterans Affairs health system. Read More

View Article
November 2018

Impact of Flushing Response on the Relationship between Alcohol Consumption and Gamma-glutamyl Transpeptidase: the KOBE study.

Nihon Arukoru Yakubutsu Igakkai Zasshi 2016 Jun;51(3):173-183

Individuals with an inactive acetaldehyde dehydrogenase 2 have an. elevated level of serum acetaldehyde after drinking alcohol, and this may cause an alcohol flushing response with symptoms such as facial flushing, tachycardia, headache, and nausea. Recent studies have suggested that the flushing response influences the association between alcohol consumption and various health-related outcomes. Read More

View Article

Effects of Alcohol Consumption and Metabolic Syndrome on Mortality in Patients with Non-alcoholic and Alcohol-Related Fatty Liver Disease.

Clin Gastroenterol Hepatol 2018 Nov 23. Epub 2018 Nov 23.

Center for Outcomes Research in Liver Diseases, Washington, DC, USA.

Background & Aims: Non-alcoholic and alcohol-related fatty liver disease are overlapping diseases in which metabolic syndrome and alcohol consumption each contribute to progressive liver disease. We aimed to assess the effects of alcohol consumption and metabolic syndrome on mortality in individuals with fatty liver.

Methods: We searched the National Health and Nutrition and Examination Survey III for adults (20-74 years old) with hepatic steatosis, detected by ultrasound, for whom mortality and follow-up data were available. Read More

View Article
November 2018
8 Reads
7.900 Impact Factor

Changes in Healthcare Encounter Rates Possibly Related to Cannabis or Alcohol following Legalization of Recreational Marijuana in a Safety-Net Hospital: An Interrupted Time Series Analysis.

J Addict Med 2018 Nov 20. Epub 2018 Nov 20.

Department of Medicine, Division of Hospital Medicine, Denver Health Medical Center, Denver (SLC, AK, MLH); Department of Medicine, Division of General Internal Medicine (SLC); Department of Family Medicine (SLC); Department of Psychiatry (CJH); Department of Medicine, Division of Hospital Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO (AK).

Objectives: Liberalization of marijuana laws in Colorado contributed to increases in cannabis-related adverse events over time. We examined characteristics of patients with healthcare encounters possibly related to cannabis and assessed the temporal association between legalization of recreational marijuana and healthcare encounters possibly attributed to cannabis.

Methods: Annual encounter rates possibly related to cannabis and alcohol were compared using negative binomial regression. Read More

View Article
November 2018
1 Read

Failed attempts to improve the reliability of the alcohol visual probe task following empirical recommendations.

Psychol Addict Behav 2018 Nov 26. Epub 2018 Nov 26.

Department of Psychological Sciences, University of Liverpool.

The visual probe task (VPT) is a computerized task used to measure attentional bias to substance-related stimuli. Little research has examined the psychometric properties of the VPT, despite concerns it demonstrates poor test-retest reliability and internal consistency. These issues can reduce confidence in inferences based on VPT performance. Read More

View Article
November 2018
1 Read

Relapse of drunk driving and association with traffic accidents, alcohol-related problems and biomarkers of impulsivity.

Acta Neuropsychiatr 2018 Nov 26:1-9. Epub 2018 Nov 26.

1Division of Neuropsychopharmacology, Department of Psychology,University of Tartu,Estonia.

Objective: Individual biological predispositions should play a role in risky driving behaviour. Platelet monoamine oxidase (MAO) activity, dopamine transporter gene (DAT1) and neuropeptide S receptor 1 (NPSR1) gene polymorphisms have been identified as markers of impulsivity, alcohol use and excessive risk-taking. We aimed to find out how this knowledge on neurobiology of impulsivity applies to drunk driving and traffic behaviour in general. Read More

View Article
November 2018

Correlates and outcomes of alcohol use after single solid organ transplantation: A systematic review and meta-analysis.

Transplant Rev (Orlando) 2018 Sep 28. Epub 2018 Sep 28.

Transplantation program, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

Background: Reviews on alcohol use in transplant recipients focus on liver recipients and their risk of post-transplant rejection, but do not assess alcohol use in kidney, heart, or lung transplant recipients. This systematic review and meta-analysis aims to synthesize the evidence on correlates and outcomes of any alcohol use and at-risk drinking after solid organ transplantation (Tx).

Methods: We searched 4 databases for quantitative studies in adult heart, liver, kidney and lung Tx recipients, investigating associations between post-Tx alcohol use and correlates and/or clinical, economic or quality of life outcomes. Read More

View Article
September 2018
3 Reads

Place of death and factors associated with hospital death in patients who have died from liver disease in England: a national population-based study.

Lancet Gastroenterol Hepatol 2018 Nov 21. Epub 2018 Nov 21.

Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, London, UK.

Background: Liver disease is a major cause of mortality, with high numbers of hospital deaths, and disproportionately affects people younger than 65 years. This study aims to examine the place of death and factors associated with hospital death for people who died from liver disease.

Method: We did a national population-based, observational study using the National Death Registration Database from the Office for National Statistics, 2001-14. Read More

View Article
November 2018
8 Reads

Childhood maltreatment and alcohol use in young adulthood: the role of self-regulation processes.

Addict Behav 2018 Nov 8;90:241-249. Epub 2018 Nov 8.

Prevention and Control Program, University of Hawaii Cancer Center, Honolulu, HI, United States.

Introduction: Childhood maltreatment has been linked to later alcohol use and disorders. Few studies have examined the pathways linking child maltreatment to alcohol use during the transition to adulthood. Currently, minimal understanding of such developmental pathways limits the success of alcohol prevention and intervention efforts for this highly vulnerable population. Read More

View Article
November 2018

Diagnosis and treatment of alcohol use disorder in patients with end-stage alcoholic liver disease.

Hepatology 2018 Nov 24. Epub 2018 Nov 24.

"G. Fontana" Centre for the Study and Multidisciplinary Treatment of Alcohol Addiction, Department of Medical and Surgical Sciences, University of Bologna, Italy.

Almost 14-30% of the world's population is affected by alcohol use disorder (AUD), and excessive alcohol consumption represents the most common cause of liver disease in the western world. The clinical picture of alcoholic end-stage liver disease is rendered extremely complex as manifestations such as alcohol withdrawal syndrome, craving and physical dependence, as well as extrahepatic alcohol-related diseases merge with the complications of advanced cirrhosis. This makes AUD recognition and assessment difficult and its management arduous as many drugs commonly employed to treat complications such as alcohol withdrawal syndrome are often contraindicated by the presence of hepatic encephalopathy or hepatorenal syndrome. Read More

View Article
November 2018
6 Reads

Alcohol-related seizures may be associated with more severe depression, alcohol dependence syndrome, and more pronounced alcohol-related problems.

Epilepsy Behav 2018 Nov 20. Epub 2018 Nov 20.

Riga Stradins University, Dzirciemaiela 16, Rīga LV-1007, Latvia; Department of Neurology and Neurosurgery, Riga East Clinical University Hospital "Gailezers", Hipokrata iela 2, Rīga LV-1039, Latvia.

Severe alcohol abuse and related medical and social functioning risks, as well as clinically significant depression, are common in patients who are admitted to hospital with alcohol-related seizures (ARS) and significantly affect the quality of life of the patient. Compared with studies involving patients with alcohol dependence, no large-scale studies with the aim of finding the prevalence and severity of depression and its most commonly affected aspects for patients with ARS have been carried out in Latvia yet. The habits and frequency of alcohol use in correlation to depression and its severity are also not known. Read More

View Article
November 2018
1 Read

Problematic social networking site usage and substance use by young adolescents.

BMC Pediatr 2018 Nov 23;18(1):367. Epub 2018 Nov 23.

Hygiene and Public Health Unit, University of Padova, Padova, Italy.

Background: Substance use and abuse by young adolescents has become a serious issue for public health services, and several socio-environmental factors can influence how vulnerable a young adolescent may be to their appeal. The present study was devised to examine whether substance use in early adolescence is associated with problematic social networking site usage (PSNSU).

Methods: In the academic year 2013-2014, secondary schools in Padua (north-eastern Italy) were involved in a survey called "Pinocchio". Read More

View Article
November 2018
7 Reads

Suppressing effect of CMPPE, a new positive allosteric modulator of the GABA receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats.

Alcohol 2018 May 31;75:79-87. Epub 2018 May 31.

Neuroscience Institute, Section of Cagliari, National Research Council of Italy, I-09042 Monserrato, CA, Italy. Electronic address:

Positive allosteric modulators (PAMs) of the GABA receptor constitute a class of pharmacological agents gaining increasing attention in the alcohol research field because of their ability to suppress several alcohol-related behaviors in rodents. CMPPE is a novel GABA PAM, still limitedly characterized in vivo. It was therefore of interest to test its ability to affect operant, oral self-administration of alcohol and cue-induced reinstatement of alcohol seeking in alcohol-preferring rats. Read More

View Article
May 2018
3 Reads

Use of Alcohol Protective Behavioral Strategies as a Moderator of the Alcohol Use-Consequences Relationship: Evidence from Multiple Replications.

Subst Use Misuse 2018 Nov 23:1-11. Epub 2018 Nov 23.

a Center on Alcoholism, Substance Abuse, & Addictions , University of New Mexico , Albuquerque , NM , USA.

Background: The use of protective behavioral strategies (PBS) has been found to attenuate the relationship between alcohol use and related consequences.

Objectives: The current study examined PBS use as a moderator of the association between alcohol use and consequences in multiple samples (N =  9) of college students with different sample sizes (e.g. Read More

View Article
November 2018
1 Read

Alcohol-related peripheral neuropathy: a systematic review and meta-analysis.

J Neurol 2018 Nov 22. Epub 2018 Nov 22.

Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.

The primary aim of this systematic review was to establish the prevalence, character, and risk factors of peripheral neuropathy amongst chronic alcohol abusers and to identify the most appropriate management strategies. In this review, possible pathogenetic mechanisms are also discussed. A systematic, computer-based search was conducted using the PubMed database. Read More

View Article
November 2018
3 Reads

Alcohol-related social and health service use patterns as predictors of death and remission in patients with AUD.

J Subst Abuse Treat 2019 Jan 31;96:65-74. Epub 2018 Oct 31.

Institute of Public Health and Clinical Nutrition, PO Box 1627, FI-70211, University of Eastern Finland, Kuopio, Finland; National Institute for Health and Welfare, PO Box 30, FI-00271 Helsinki, Finland; Joint Municipal Authority for North Karelia Social and Health Services (Siun sote), Tikkamäentie 16, 80210 Joensuu, Finland.

View Article
January 2019
3 Reads

Comparison of age of first drink and age of first intoxication as predictors of substance use and mental health problems in adulthood.

Drug Alcohol Depend 2018 Nov 6;194:238-243. Epub 2018 Nov 6.

Department of Psychological Medicine, University of Otago, 2 Riccarton Ave., PO Box 4345, Christchurch, 8140, New Zealand.

Background: International public policy on age of first alcoholic drink (AFD) has emphasised the long-term benefits of delaying AFD. This study aimed to compare AFD to age of first intoxication (AFI) as predictors of substance use disorder and mental disorder outcomes in adulthood.

Methods: Data were obtained from a longitudinal birth cohort in Christchurch, New Zealand. Read More

View Article
November 2018
1 Read

Prenatal Alcohol Exposure and Child Psychosocial Behavior: A Sibling Fixed-Effects Analysis.

Front Psychiatry 2018 6;9:570. Epub 2018 Nov 6.

Department of Global Health Promotion, Tokyo Medical and Dental University, Tokyo, Japan.

The association between low levels of alcohol consumption during pregnancy and children's health remains unclear because of the difficulty in ruling out residual genetic and environmental confounding factors. In this study, using a within-family sibling fixed effects design, we sought to examine the association between low prenatal alcohol exposures (PAE) and children's overall psychosocial behavior in a Japanese cohort. We used maternal and sibling data from the Japanese Study of Stratification, Health, Income and Neighborhood 2012-2013. Read More

View Article
November 2018
8 Reads

Alcohol and the Law.

Clin Liver Dis 2019 Feb;23(1):25-38

Section of Gastroenterology, Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

In the intersection of alcohol ingestion with the law, medical ethics, and public safety, physicians are often unsure about how to proceed. Physicians' primary focus should be on patient education with an ethical and legal duty to warn the patient of the adverse effects of alcohol. Warning third parties of potential harm related to alcohol-related impairment may involve a breach of patient confidentiality; therefore it should only be undertaken after careful analysis suggests that the risk for significant harm exceeds the burden that results to the patient from warning others. Read More

View Article
February 2019
2 Reads

Histopathology of Alcohol-Related Liver Diseases.

Clin Liver Dis 2019 Feb;23(1):11-23

Department of Pathology, The Department of Veteran Affairs New York Harbor Healthcare System, 800 Poly Place, Brooklyn, NY 11209, USA.

Excessive alcohol consumption can lead to a spectrum of liver histopathology, including steatosis, steatohepatitis, foamy degeneration, fatty liver with cholestasis, and cirrhosis. Although variability in sampling and pathologist interpretation are of some concern, liver biopsy remains the gold standard for distinguishing between steatohepatitis and noninflammatory histologic patterns of injury that can also cause the clinical syndrome of alcohol-related hepatitis. Liver biopsy is not routinely recommended to ascertain a diagnosis of alcohol-related liver disease in patients with an uncertain alcohol history, because the histologic features of alcohol-related liver diseases can be found in other diseases, including nonalcoholic steatohepatitis and drug-induced liver injury. Read More

View Article
February 2019
1 Read

Effect of alcohol on the interleukin 6-mediated inflammatory response in a new mouse model of acute-on-chronic liver injury.

Biochim Biophys Acta Mol Basis Dis 2018 Nov 15;1865(2):298-307. Epub 2018 Nov 15.

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.

Background And Aims: ACLF is usually associated with a precipitant in the setting of a chronically damaged liver. We aim to combine a mouse model with a pre-injured liver (Abcb4/Mdr2) with a recently standardized ethanol feeding model to dissect alcohol-related inflammatory responses in this model.

Method: Ten (n = 64) and 15 (n = 64) week old wild-type (WT) C57BL/6 J and Abcb4 knock-out (KO) mice were either fed control (WT/Cont and KO/Cont groups) or liquid ethanol diet (5% v/v) followed by an ethanol binge (4 mg/kg) (WT/EtOH and KO/EtOH groups). Read More

View Article
November 2018
5 Reads

Alcohol abuse in road traffic: medical-legal aspects.

Soud Lek 2018 ;63(2):14-18

Alcohol-affected road users - pedestrians or drivers are a significant risk factor for road accidents and injuries. Therefore, the issue of alcohol-related traffic accidents is logically a subject of great attention. However, the statistics results of the General Prosecutor's Office of the Slovak Republic and of the Police Force of the Slovak Republic clearly confirm the fact that in the Slovak Republic the above-mentioned problem of the whole society is not sufficiently eliminated. Read More

View Article
January 2018
2 Reads

Alcohol as an issue of the public health in the Czech Republic: facts and context.

Cas Lek Cesk 2018 ;157(5):248-253

Alcohol consumption has a direct impact on the extent of the alcohol related damage, including health and quality of life impacts. Alcohol policy, especially the availability of alcoholic beverages, affects the overall alcohol consumption. The Czech Republic is a very liberal country in relation to alcohol consumption and is known for the widespread availability of cheap alcohol beverages. Read More

View Article
January 2018

The Role of Social Support in Motivating Reductions in Alcohol Use: A Test of Three Models of Social Support in Alcohol-Impaired Drivers.

Alcohol Clin Exp Res 2018 Nov 15. Epub 2018 Nov 15.

Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.

Background: Social support has been linked to many therapeutic benefits (e.g., treatment retention, reduced posttreatment relapse) for individuals with alcohol use disorder. Read More

View Article
November 2018

Discussing alcohol in medicines use reviews: experiences of patients in a community pharmacy context.

Int J Pharm Pract 2018 Nov 15. Epub 2018 Nov 15.

Research Department of Practice and Policy, UCL School of Pharmacy, London, UK.

Objectives: Although pharmacist-led medicines use reviews (MURs) are effective for medicines management, little is understood about patients' experiences of alcohol-related advice delivered therein. Sampling a population at high risk for misuse (within an area of socio-economic deprivation), we explored patient experiences of alcohol-related MURs.

Methods: Two focus groups were conducted with patients who had discussed alcohol in an MUR in the preceding 3 months (n = 9). Read More

View Article
November 2018
5 Reads

Phosphoinositide-specific phospholipase C in normal human liver and in alcohol abuse.

J Cell Biochem 2018 Nov 13. Epub 2018 Nov 13.

Department of Sensory Organs, Sapienza University of Rome, Rome, Italy.

The phosphoinositide (PI) signal transduction pathway participates in liver metabolism. Abnormal activity or expression of PI-specific phospholipase C (PLC) enzymes has been described in different liver diseases. We resume the role of the PI metabolism in liver and PLC abnormalities in different liver diseases. Read More

View Article
November 2018
3 Reads

But were you drunk? Intoxication during sexual assault in Norway.

Eur J Psychotraumatol 2018 5;9(1):1539059. Epub 2018 Nov 5.

Norwegian Centre for Violence and Traumatic Stress Studies, Oslo, Norway.

: Sexual assault often occurs when victims are intoxicated. Rape myth research indicates that intoxicated assaults are sometimes seen as less severe or not as 'real' assaults; however, it is unclear if victims of intoxicated sexual assaults differ from victims of non-intoxicated assaults in terms of health and functioning. : We investigated possible differences in mental health, social support and loneliness between intoxicated and non-intoxicated sexual assault victims. Read More

View Article
November 2018
1 Read

Medical intensive care unit admission among patients with and without HIV, hepatitis C virus, and alcohol-related diagnoses in the United States: a national, retrospective cohort study, 1997-2014.

J Acquir Immune Defic Syndr 2018 Oct 29. Epub 2018 Oct 29.

Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Background: HIV, hepatitis C virus (HCV), and alcohol-related diagnoses (ARD) independently contribute increased risk for all-cause hospitalization. We sought to determine annual medical intensive care unit (MICU) admission rates and relative risk of MICU admission between 1997 and 2014 among people with and without HIV, HCV, and ARD, using data from the largest HIV and HCV care provider in the United States.

Setting: Veterans Health Administration. Read More

View Article
October 2018
3 Reads
4.560 Impact Factor

Positive Attitude Toward Alcohol Predicts Actual Consumption in Young Adults: An Ecological Implicit Association Test.

J Stud Alcohol Drugs 2018 Sep;79(5):733-740

Univ. Lille, CNRS, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, Lille, France.

Objective: Excessive alcohol drinking, particularly among college students, is a major health concern worldwide. The implicit associations between alcohol-related concepts and affective attributes have been repeatedly postulated as a reliable predictor of these drinking behaviors. The Implicit Association Test (IAT) is considered one of the most reliable tasks for measuring these associations and their impact on actual alcohol consumption. Read More

View Article
September 2018
6 Reads

A Meta-Analysis of Computer-Delivered Drinking Interventions for College Students: A Comprehensive Review of Studies From 2010 to 2016.

J Stud Alcohol Drugs 2018 Sep;79(5):686-696

The University of Kentucky, College of Arts and Sciences, Department of Psychology, Lexington, Kentucky.

Objective: Computer-delivered drinking interventions (CDIs) are administered to tens of thousands of college students each year, yet recent evidence for their efficacy has not been summarized. This meta-analysis extends the work of past reviews and investigates the efficacy of CDIs in reducing college students' alcohol consumption and alcohol-related harms.

Method: Following the systematic review standards set by PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), the literature was searched for published and unpublished data available from 2010 to 2016. Read More

View Article
September 2018

Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement.

JAMA 2018 11;320(18):1899-1909

Tufts University, Medford, Massachusetts.

Importance: Excessive alcohol use is one of the most common causes of premature mortality in the United States. From 2006 to 2010, an estimated 88 000 alcohol-attributable deaths occurred annually in the United States, caused by both acute conditions (eg, injuries from motor vehicle collisions) and chronic conditions (eg, alcoholic liver disease). Alcohol use during pregnancy is also one of the major preventable causes of birth defects and developmental disabilities. Read More

View Article
November 2018
13 Reads
35.290 Impact Factor

Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.

JAMA 2018 11;320(18):1910-1928

University of North Carolina at Chapel Hill.

Importance: Unhealthy alcohol use is common, increasing, and a leading cause of premature mortality.

Objective: To review literature on the effectiveness and harms of screening and counseling for unhealthy alcohol use to inform the US Preventive Services Task Force.

Data Sources: MEDLINE, PubMed, PsycINFO, and the Cochrane Central Register of Controlled Trials through October 12, 2017; literature surveillance through August 1, 2018. Read More

View Article
November 2018
3 Reads