924,684 results match your criteria Alcohol and alcoholism Oxford Oxfordshire[Journal]


Mu opioid receptors in the medial habenula contribute to naloxone aversion.

Neuropsychopharmacology 2019 Apr 20. Epub 2019 Apr 20.

McGill University, Faculty of Medicine, Douglas Research Centre, Montreal, Canada.

The medial habenula (MHb) is considered a brain center regulating aversive states. The mu opioid receptor (MOR) has been traditionally studied at the level of nociceptive and mesolimbic circuits, for key roles in pain relief and reward processing. MOR is also densely expressed in MHb, however, MOR function at this brain site is virtually unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0395-7DOI Listing
April 2019
1 Read

Postoperative Pain and Opioid Use After Thyroid and Parathyroid Surgery-A Pilot, Prospective SMS-Based Survey.

J Surg Res 2019 Apr 17;240:236-240. Epub 2019 Apr 17.

University of California San Francisco, Section of Endocrine Surgery, San Francisco, California.

Background: New persistent opioid use has been identified following minor surgical procedures and may contribute to the national opioid epidemic. Prescription patterns vary and we have limited data on patient pain experiences in the outpatient setting. We devised a novel short messaging service survey to record pain scores and opioid use following outpatient thyroid or parathyroid surgery. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.016DOI Listing

Coupling the post-extraction process to remove residual lignin and alter the recalcitrant structures for improving the enzymatic digestibility of acid-pretreated bamboo residues.

Bioresour Technol 2019 Apr 16;285:121355. Epub 2019 Apr 16.

Key Laboratory of Forestry Genetics & Biotechnology (Nanjing Forestry University), Ministry of Education, Nanjing 210037, China; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

In this work, a mild and facile post-extraction using different reagents was evaluated to overcome these recalcitrance for improving the enzymatic digestibility of acid-pretreated bamboo residues by removing the lignin and disrupting its inhibitory properties. Results showed that the enzymatic digestibility of acid-pretreated bamboo residues can be improved from 15.4% to 61. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.121355DOI Listing

Nonalcoholic steatohepatitis and hepatocellular carcinoma: crying wolf or promoting healthy living?

Authors:
Alain Braillon

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

University Hospital, 80000 Amiens, France. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.04.029DOI Listing

Increased Risk of Death in First Year After Liver Transplantation Among Patients with Nonalcoholic Steatohepatitis vs Liver Disease of Other Etiologies.

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Gastroenterology, Henry Ford Hospital, Detroit, Michigan, United States.

Background & Aims: An increasing number of patients with non-alcoholic steatohepatitis (NASH) require liver transplantation. We compared outcomes of patients with liver diseases of different etiologies (NASH, hepatitis C virus [HCV]-associated liver disease, and alcohol-associated liver disease [ALD]).

Methods: We analyzed data from the United Network for Organ Sharing registry on 6344 patients who underwent liver transplantation for NASH, 17,037 for cirrhosis from chronic HCV infection, and 9279 for ALD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
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http://dx.doi.org/10.1016/j.cgh.2019.04.033DOI Listing
April 2019
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Microglial alterations induced by psychoactive drugs: A possible mechanism in substance use disorder?

Semin Cell Dev Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dynamic and Clinical Psychology, University of Rome "La Sapienza," Via degli Apuli 1, 00185, Rome, Italy; IRCCS Santa Lucia Foundation, Via Fosso di Fiorano 64, 00143, Rome, Italy. Electronic address:

Recently, the xenobiotic hypothesis has implicated the immune system in targeting substances of abuse as foreign molecules and stimulating inflammatory responses. Microglial cells are the resident immune cells of the central nervous system and function in homeostatic surveillance. Microglial changes that are induced by exposure to substances of abuse appear to mediate in part the establishment of addiction and the persistence of drug-mediated biological and behavioral changes. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.008DOI Listing

Lonicera japonica extract increases metformin distribution in the liver without change of systemic exposed metformin in rats.

J Ethnopharmacol 2019 Apr 17:111892. Epub 2019 Apr 17.

College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University_Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Flower and flower bud of Lonicera japonica, Lonicerae Flos, have been popularly used as medicinal plant for the treatment of clearing heat and thirst, thereby improving diabetic or diabetic associated symptoms (thirst and poor eyesight).

Aim Of The Study: Organic cation transporters (OCTs) and multi-drug and toxin extrusion proteins (MATEs) are known to play important roles in metformin transport in the liver and kidneys. Thus, there might be interactions between Lonicerae Flos and metformin via OCTs and MATEs. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111892DOI Listing
April 2019
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The silent epidemic of chronic pain in older adults.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

Lipid Peroxidation Unit, Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, USA. Electronic address:

Chronic pain is highly prevalent among older adults where it is associated with significant suffering, disability, social isolation, and greater costs and burden to health care systems. Pharmaceutical treatment of chronic pain in older adults is usually only partially effective and is often limited by side effects including urinary retention, constipation, sedation, cognitive impairment, and increased risk of falls. Since older adults are underrepresented in clinical trials testing treatments for chronic pain, the potential impacts of polypharmacy and frailty on reported outcomes and side effect profiles are largely unknown. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.04.006DOI Listing
April 2019
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Nisin incorporation enhances the inactivation of lactic acid bacteria during the acid wash step of bioethanol production from sugarcane juice.

Lett Appl Microbiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Food Science & Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Bioethanol fermentation is continuously exposed to contamination by Lactic Acid Bacteria (LAB). In the present study, the effect of adding nisin (250 mg L ) to the acid wash on the viability of five bacterial contaminants were evaluated both alone and in co-incubation with Saccharomyces cerevisiae. Additionally, fed-batch fermentation was performed using an acid or acid/nisin wash for S. Read More

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http://dx.doi.org/10.1111/lam.13165DOI Listing

Assessment of the Performance of Solid Phase Extraction Based on Pipette Tip Employing a Hybrid Molecularly Imprinted Polymer as an Adsorbent for Enantioselective Determination of Albendazole Sulfoxide.

J Chromatogr Sci 2019 Apr 20. Epub 2019 Apr 20.

Departamento de Ciências Naturais, Universidade Federal de São João del-Rei, Campus Dom Bosco, Praça Dom Helvécio 74, Fábricas, 36301-160, São João del-Rei, Minas Gerais, Brazil.

Herein, an organic-inorganic hybrid molecularly imprinted polymer (MIP) was successfully synthesized with albendazole sulfoxide (ABZSO) as a template and 3-(trimethoxysilyl)propyl methacrylate, a bifunctional group compound, as a single cross-linking agent. In this study, a simple method using HPLC-DAD was developed for the determination of ABZSO enantiomers in human urine using pipette tip-based molecularly imprinted polymer solid phase extraction (PT-MIP-SPE). Enantioseparation with satisfactory retention times (5. Read More

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https://academic.oup.com/chromsci/advance-article/doi/10.109
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http://dx.doi.org/10.1093/chromsci/bmz036DOI Listing
April 2019
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Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population.

CNS Neurosci Ther 2019 Apr 19. Epub 2019 Apr 19.

Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Aims: Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.

Methods: Three μ-opioid receptor gene (OPRM1) variants and two κ-opioid receptor gene (OPRK1) variants were examined in 314 male patients with AUD and 324 male controls. Read More

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http://dx.doi.org/10.1111/cns.13138DOI Listing

Prebiotic Syntheses Under Shock in the Water - Formamide - Potassium Bicarbonate - Sodium Hydroxide System.

Orig Life Evol Biosph 2019 Apr 19. Epub 2019 Apr 19.

A.M. Butlerov Chemistry Institute, Kazan Federal University, Kremlevskaya St., 18, Kazan, Russian Federation, 420008.

Syntheses under shock in nitrogen bubbled samples of the water - formamide - bicarbonate - sodium hydroxide system at pH 8.63, 9.46 and 10. Read More

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http://dx.doi.org/10.1007/s11084-019-09575-8DOI Listing

The Influence of Electrostatic Controls on MDI Size Distribution Measurements.

AAPS PharmSciTech 2019 Apr 19;20(5):170. Epub 2019 Apr 19.

3M Drug Delivery Systems, Inhalation Drug Delivery, 3M Center, Building 260-3A-05, St. Paul, Minnesota, 55144-1000, USA.

Cascade impactor testing is widely used to characterize the aerodynamic particle-size distribution of metered dose inhaler aerosols. Charge is often imparted to MDI aerosols by triboelectrification as formulation rapidly travels through the valve stem and actuator during atomization. The presence of charge on MDI aerosols can impact the accuracy and reproducibility of APSD measurements made using cascade impactors. Read More

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http://link.springer.com/10.1208/s12249-019-1354-7
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http://dx.doi.org/10.1208/s12249-019-1354-7DOI Listing
April 2019
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Enhanced Permeation of Methotrexate via Loading into Ultra-permeable Niosomal Vesicles: Fabrication, Statistical Optimization, Ex Vivo Studies, and In Vivo Skin Deposition and Tolerability.

AAPS PharmSciTech 2019 Apr 19;20(5):171. Epub 2019 Apr 19.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo, 11562, Egypt.

The aim of this study was to incorporate methotrexate (MTX) into ultra-permeable niosomal vesicles, containing cremophor RH40 as an edge activator (EA) and polyvinyl alcohol (PVA) as a stabilizer to enhance the drug permeation. Formulae were prepared by ethanol injection method following a Box-Behnken design in order to optimize the formulation variables (EA%, stabilizer %, and sonication time). To investigate the role of both cremophor RH40 and PVA, conventional MTX niosomes and MTX niosomes containing PVA only were fabricated. Read More

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http://dx.doi.org/10.1208/s12249-019-1380-5DOI Listing

Cross-Sectional Study of Sexual Behavior, Alcohol Use, and Mental Health Conditions Associated With Sexually Transmitted Infections Among Deploying Shipboard US Military Personnel.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Defense HIV/AIDS Prevention Program, Defense Health Agency, 140 Sylvester Rd Bldg 306, San Diego, CA 92106.

Introduction: Limited comprehensive data exist on risk behavior associated with sexually transmitted infections (STI) among ship-assigned US military personnel during the predeployment time period (PDT). This study examined whether sexual risk behaviors, alcohol use, involuntary drug consumption (IDC), posttraumatic stress disorder (PTSD), and depression during the 12 months prior to deployment were associated with provider-diagnosed STIs in this population.

Materials And Methods: Using cross-sectional data collected during 2012-2014 among sexually active personnel, multivariable regression assessed factors associated with STIs among all men (n = 1,831). Read More

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https://academic.oup.com/milmed/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/milmed/usz070DOI Listing
April 2019
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Brazilian Jiu Jitsu Training for US Service Members and Veterans with Symptoms of PTSD.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd, Tampa, FL 33612.

Introduction: The United States has been actively involved in major armed conflicts over the last 15 years. As a result, a significant proportion of active duty service personnel and returning veterans have endured combat, putting them at risk for developing post-traumatic stress disorder (PTSD), a disabling disorder that may occur after exposure to a traumatic event. Current therapies often require long-term, time-intensive and costly commitment from the patient and have variable degrees of success. Read More

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https://academic.oup.com/milmed/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/milmed/usz074DOI Listing
April 2019
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MnoSR is a bona fide two-component system involved in methylotrophic metabolism in .

Appl Environ Microbiol 2019 Apr 19. Epub 2019 Apr 19.

Microbiology and Molecular Biology Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Bhopal, India

() and several other mycobacteria are able to utilize methanol as the sole source of carbon and energy. We recently showed that N,N-dimethyl-p-nitrosoaniline (NDMA)-dependent methanol dehydrogenase (Mno) is essential for the growth of on methanol. Although Mno from this bacterium shares high homology with other known methanol dehydrogenases, methanol metabolism in differs significantly from other described methylotrophs. Read More

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http://aem.asm.org/lookup/doi/10.1128/AEM.00535-19
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http://dx.doi.org/10.1128/AEM.00535-19DOI Listing
April 2019
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The role of sphingosine kinase 2 in alcoholic liver disease.

Dig Liver Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology and Immunology, Medical College of Virginia and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, USA. Electronic address:

Alcoholic liver disease (ALD) is one of the most common liver diseases worldwide. However, the exact mechanisms underlying ALD remain unclear. Previous studies reported that sphingosine kinase 2 (SphK2) plays an essential role in regulating hepatic lipid metabolism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658193052
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http://dx.doi.org/10.1016/j.dld.2019.03.020DOI Listing
April 2019
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Cannabis abuse and dependence in kidney transplant candidates.

J Psychosom Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA. Electronic address:

Objective: Cannabis is the most commonly used non-alcohol intoxicant in the general population. There are no consistent guidelines on the implications of cannabis abuse and dependence (CAD) in kidney transplant candidates. The aims of this study were to characterize kidney transplant candidates with comorbid CAD and examine the implications of CAD on transplant candidacy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223999183101
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http://dx.doi.org/10.1016/j.jpsychores.2019.04.004DOI Listing
April 2019
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Partial nitrification in entrapped-cell-based reactors with two different cell-to-matrix ratios: performance, microenvironment, and microbial community.

J Environ Sci Health A Tox Hazard Subst Environ Eng 2019 Apr 19:1-10. Epub 2019 Apr 19.

e Environmental Assessment and Technology for Hazardous Waste Management Research Center, Faculty of Environmental Management , Prince of Songkla University , Songkhla , Thailand.

In this study, we investigated the effect of different cell-to-matrix ratios (1% and 4%) on the partial nitrification of phosphorylated polyvinyl alcohol-entrapped-cell-based reactors and evaluated the microenvironment, microbial community, and microbial localization within the gel matrices. The results indicated that the reactor with a 1% cell-to-matrix ratio required 184 days of operation to reach partial nitrification that produced anaerobic ammonium oxidation-suitable effluent. In contrast, partial nitrification was achieved from the beginning of the operation of the reactor with the 4% cell-to-matrix ratio. Read More

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https://www.tandfonline.com/doi/full/10.1080/10934529.2019.1
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http://dx.doi.org/10.1080/10934529.2019.1604011DOI Listing
April 2019
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Anisotropic Cellulose Nanofibers/Polyvinyl Alcohol/Graphene Aerogels Fabricated by Directional Freeze-drying as Effective Oil Adsorbents.

Polymers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, China.

Under the current situation of frequent oil spills, the development of green and recyclable high-efficiency oil-absorbing aerogel materials has attracted wide attention from researchers. In this study, we report a high-strength, three-dimensional hydrophobic cellulose nanofiber (CNF)/polyvinyl alcohol (PVA)/graphene oxide (GO) composite aerogel with an anisotropic porous structure, which was fabricated by directional freeze-drying technology using anisotropically grown ice crystals as a template, followed by hydrophobic treatment with a simple dip coating process. The prepared composite aerogel presented anisotropic multi-level pore microstructures, low density (17. Read More

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http://dx.doi.org/10.3390/polym11040712DOI Listing

An In Vitro Study of the Influence of Extracts on the Microbiota Modulation Process, In Patients with Hypertension.

Pharmaceutics 2019 Apr 18;11(4). Epub 2019 Apr 18.

Department of Genetics, ICUB-Research Institute of the University of Bucharest, 36-46 Bd. M. Kogalniceanu, 5th District, 050107 Bucharest, Romania.

The multiple causes of cardiovascular diseases signify a major incidence and developmental risk of this pathology. One of the processes accountable for this pathologic development is the instauration of dysbiosis and its connection with an inflammatory process. Low antioxidant colonic protection encourages the progression of inflammation, with cardiovascular dysfunctions being a secondary consequence of the dysbiosis. Read More

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https://www.mdpi.com/1999-4923/11/4/191
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http://dx.doi.org/10.3390/pharmaceutics11040191DOI Listing
April 2019
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Psychiatric Disorders and Alcohol Consumption Among Low-Income African Americans:Gender Differences.

Brain Sci 2019 Apr 18;9(4). Epub 2019 Apr 18.

Department of Family Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.

Background: Although cooccurrence of nonsubstance use disorders (non-SUDs) and substance use is well-established in the literature, most of what we know in this regard is derived from studies that have recruited predominantly White sample populations. As a result, there is a gap in knowledge on this link among low-income African Americans (AAs). There is also a need to understand how low-income AA men and women differ in these associations. Read More

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http://dx.doi.org/10.3390/brainsci9040086DOI Listing

Health-Related Quality of Life and Its Determinants among Criminal Police Officers.

Int J Environ Res Public Health 2019 Apr 18;16(8). Epub 2019 Apr 18.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.

Criminal police officers are viewed as having a very tiring and stressful job, one that is closely correlated with work disability and other factors that might impair quality of life. Few studies have addressed the issue of health-related quality of life (HRQoL) in this population. Thus, this study aimed to assess the HRQoL of criminal police officers compared with the general adult population and identify determinants associated with HRQoL. Read More

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https://www.mdpi.com/1660-4601/16/8/1398
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http://dx.doi.org/10.3390/ijerph16081398DOI Listing
April 2019
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Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats.

Neuropsychopharmacology 2019 Apr 19. Epub 2019 Apr 19.

Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.

Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of environmental variables, can modify the reward value of food. Impulsivity, a predisposition toward rapid unplanned reactions to stimuli, is one of the multifaceted determinants underlying the etiology of dysregulated eating and its evolving pathogenesis. The medial prefrontal cortex (mPFC) is a major neural director of reward-driven behavior and impulsivity. Read More

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http://dx.doi.org/10.1038/s41386-019-0394-8DOI Listing

Catalytic co-pyrolysis of red cedar with methane to produce upgraded bio-oil.

Bioresour Technol 2019 Apr 9;285:121299. Epub 2019 Apr 9.

Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States.

Fast pyrolysis is a promising route to transform biomass into bio-oil for further refining into transportation fuels and chemicals. However, bio-oil applications suffer from several challenges due to its adverse properties. This study reports improving bio-oil properties through co-pyrolysis of biomass with methane over molybdenum/zinc (MoZn/ZHSM-5) and HZSM-5 catalysts that promote deoxygenation, decarbonylation, hydrogen transfer and aromatization reactions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608524193051
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http://dx.doi.org/10.1016/j.biortech.2019.03.138DOI Listing
April 2019
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QSAR modelling for predicting the toxic effects of traditional and derived biomass solvents on a Danio rerio biomodel.

Chemosphere 2019 Apr 10;227:480-488. Epub 2019 Apr 10.

Universidad San Jorge, Campus Universitario, Autov A23 Km 299, 50830, Villanueva de Gállego, Zaragoza, Spain. Electronic address:

The increasing interest in the development of ecofriendly solvents has led to the synthesis of benign alternative chemicals with minimized environmental impacts. These kinds of chemicals are known as Green solvents. In this work, we selected three families of solvents (furfural, lactate and levulinate families) derived from biomass that are structurally related. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.054DOI Listing

Psychological Distress among Adolescents in Laos, Mongolia, Nepal, and Sri Lanka.

Asian Nurs Res (Korean Soc Nurs Sci) 2019 Apr 16. Epub 2019 Apr 16.

Hanyang University, College of Medicine, Department of Preventive Medicine; Hanyang University, Institute for Health and Society, Seoul, Republic of Korea.

Purpose: The purpose of this study was to explore psychological distress and examine the relationship between this distress and individual, family, and school factors among adolescents in four low- and middle-income countries (LAMICs) in Asia (i.e., Laos, Mongolia, Nepal, and Sri Lanka). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19761317183023
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http://dx.doi.org/10.1016/j.anr.2019.04.001DOI Listing
April 2019
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Rheological properties of Prunus persica exudate: Potential effects of proteins and polyphenols.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Shanghai Engineering Research Center of Food Microbiology, School of Medical Instruments and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:

This study was to investigate the rheological properties of graded Prunus persica exudates (peach gums). Graded peach gums were extracted by hot water and precipitated by ethanol to obtain white peach gum polysaccharide (WPGP) and yellow peach gum polysaccharide (YPGP). Chemical analysis showed that YPGP had 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193082
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.104DOI Listing
April 2019
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The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.

Alcohol 2019 Apr 16. Epub 2019 Apr 16.

Division of Endocrine and Metabolic Disease, Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Chungbuk, 28159, South Korea.

Background: Excessive alcohol consumption is a major public health problem in East Asian countries. Alcohol use leads to a cascade of problems including increased chances of risky behavior and wide range of negative health consequences from alcoholic liver disease to upper gastric and liver cancer. These alcohol effects are known to be influenced by ethnic variability and genetics. Read More

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http://dx.doi.org/10.1016/j.alcohol.2019.03.004DOI Listing

CUE-ALCOHOL associative learning in FEMALE RATS.

Alcohol 2019 Apr 16. Epub 2019 Apr 16.

The University of Texas at Austin; Institute for Neuroscience; Department of Psychology. Electronic address:

The ability of environmental cues to trigger alcohol seeking behaviors is believed to facilitate problematic alcohol use. We previously showed that the development of this cue-evoked alcohol approach reflects cue-alcohol learning and memory in the adult male rat; however, we do not know whether the same is true for similarly aged female rats. Consequently, adult Long-Evans female rats were allowed to drink unsweetened alcohol in the homecage (MWF 24 hr two-bottle choice, 5 weeks) and subsequently split into two experimental groups: paired and unpaired. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07418329193001
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http://dx.doi.org/10.1016/j.alcohol.2019.03.003DOI Listing
April 2019
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Inhibitory action of thymol on fecal microbial activity in Tamandua tetradactyla and its effect on glucocorticoid metabolite measurement.

Gen Comp Endocrinol 2019 Apr 16. Epub 2019 Apr 16.

Instituto de Ciencia y Tecnología de los Alimentos and Facultad de Ciencias Exactas, Físicas y Naturales (FCEFyN), Universidad Nacional de Córdoba (UNC), Argentina.

Faecal glucocorticoid measurement is a potentially important tool for improving wildlife conservation, but its use is still limited by methodological issues including the need to avoid modifications of steroids by faecal microorganisms during storage. The freezing of faeces is recommended as a means of avoiding such alterations, but this is costly under non-controlled environmental conditions. The present study was designed to determine whether the application of thymol reduced the proliferation of microorganisms in the faeces of Tamandua tetradactyla and whether it influenced faecal glucocorticoid metabolite (FGM) measurements. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.04.015DOI Listing

Mitigating Acetaminophen-Induced Hepatotoxicity by Using a Water-Alcohol Extract of Phellinus caryophylli (Agaricomycetes) in a Murine Model.

Int J Med Mushrooms 2019 ;21(4):367-380

Mar Athanasious College for Advanced Studies, Tiruvalla, Tiruvalla, Kerala, India; St.Gregorios Dental College & Research Centre, Kothamangalam, Kerala, India.

This study investigates the hepatoprotective effect of a water-alcohol extract of the medicinal mushroom Phellinus caryophylli (Racib.) G. Cunn. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030388DOI Listing
January 2019
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Chemical Compounds and Antioxidant Activity of Volatile Oil from the White Jelly Mushroom, Tremella fuciformis (Tremellomycetes).

Int J Med Mushrooms 2019 ;21(3):207-214

National Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization, Ministry of Agriculture, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai, China; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, China.

To fully analyze the composition of volatile oil extracted from Tremella fuciformis, hydrodistillation (HD) and solid phase microextraction (SPME) were adopted simultaneously. In both cases, the analysis was carried out using gas chromatography-mass spectrometry and the antioxidant activity of the volatile oil was determined by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method with rutin as a positive control. Nineteen components in HD and 68 components in SPME were identified, respectively. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030099DOI Listing
January 2019

Assessing for Fetal Alcohol Spectrum Disorder.

J Popul Ther Clin Pharmacol 2019 Jan 23;26(1):e39-e55. Epub 2019 Jan 23.

Canada FASD Research Network.

Background The recommended "gold standard" for Fetal Alcohol Spectrum Disorder (FASD) assessment involves a multidisciplinary diagnostic team and comprehensive battery of neuropsychological tests to evaluate functioning across 10 brain domains. The current Canadian Guideline for diagnosis of FASD outlines a list of test measures for assessment; however, very little research exists to explore which specific tools are being used in clinical practice. Objectives The purpose of the current study was to gain a better understanding of the testing measures used by FASD clinicians in Alberta, Canada. Read More

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http://jptcp.com/index.php/jptcp/article/view/54
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http://dx.doi.org/10.22374/1710-6222.26.1.4DOI Listing
January 2019
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Enzymatic basis for C-lignin monomer biosynthesis in the seed coat of Cleome hassleriana.

Plant J 2019 Apr 19. Epub 2019 Apr 19.

BioDiscovery Institute, University of North Texas, Denton, TX.

C-lignin is a linear polymer of caffeyl alcohol, found in the seed coats of several exotic plant species, with promising properties for generation of carbon fibers and high value chemicals. In the ornamental plant Cleome hassleriana, guaiacyl (G) lignin is deposited in the seed coat for the first 6-12 days after pollination, after which G lignin deposition ceases and C-lignin accumulates, providing an excellent model system to study C-lignin biosynthesis. We performed RNA sequencing of seed coats harvested at 2-day intervals throughout development. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/tpj.14340
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http://dx.doi.org/10.1111/tpj.14340DOI Listing
April 2019
1 Read

Association Between Opioid Dose Variability and Opioid Overdose Among Adults Prescribed Long-term Opioid Therapy.

JAMA Netw Open 2019 Apr 5;2(4):e192613. Epub 2019 Apr 5.

Institute for Health Research, Kaiser Permanente Colorado, Aurora.

Importance: Attempts to discontinue opioid therapy to reduce the risk of overdose and adhere to prescribing guidelines may lead patients to be exposed to variability in opioid dosing. Such dose variability may increase the risk of opioid overdose even if therapy discontinuation is associated with a reduction in risk.

Objective: To examine the association between opioid dose variability and opioid overdose. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2613DOI Listing
April 2019
5 Reads

Is the Sum Greater than its Parts? Variations in Substance-Related Consequences by Conjoint Alcohol-Marijuana Use Patterns.

J Psychoactive Drugs 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Department of Psychology , Palo Alto University , Palo Alto , CA , USA.

Alcohol and marijuana are the most commonly used substances for college-attending young adults. This study evaluated differences in substance-specific consequence attribution by alcohol-marijuana use patterns (concurrent alcohol and marijuana [CAM; use of both substances, not at same time] and simultaneous [SAM; use of both, at same time]) as well as alcohol-only (AO). First-year college students with prior alcohol use (N = 610, 50. Read More

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http://dx.doi.org/10.1080/02791072.2019.1599473DOI Listing

The 1-Naphthol Dimer and Its Surprising Preference for π-π Stacking over Hydrogen Bonding.

J Phys Chem Lett 2019 Apr 19. Epub 2019 Apr 19.

Using chirped-pulse Fourier transform microwave spectroscopy, we have experimentally identified the most abundant dimer of an alcohol analogue of naphthalene, 1-naphthol. The 1-naphthol dimer features a V-shaped, partially overlapping π-π stacked structure with no canonical hydrogen bonds between the subunits. This structural assignment is in contradiction to an earlier study of the 1-naphthol dimer using UV-IR dip double resonance spectroscopy in the O-H stretch region, which assigns a π-stacked but also canonically hydrogen bonded structure. Read More

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http://pubs.acs.org/doi/10.1021/acs.jpclett.9b00646
Publisher Site
http://dx.doi.org/10.1021/acs.jpclett.9b00646DOI Listing
April 2019
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The Effect of Different Flushing Media Used to Aspirate Follicles on the Outcome of a Commercial Ovum Pickup-ICSI Program in Mares.

J Equine Vet Sci 2019 Apr 6;75:74-77. Epub 2019 Feb 6.

Faculty of Veterinary Medicine, Department of Equine Sciences, Utrecht University, Utrecht, The Netherlands.

The in vitro production of embryos by ovum pickup (OPU) and intracytoplasmic sperm injection (ICSI) is gaining popularity among horse breeders and veterinarians. Various collection media are available for flushing follicles during OPU. The objective of this study was to determine whether the type of flushing media used to aspirate follicles and collect oocytes influences the outcome of a commercial equine OPU-ICSI program. Read More

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http://dx.doi.org/10.1016/j.jevs.2019.01.015DOI Listing

[Progression of Chronic Heart Failure: Prognostic Criteria and Non-Drug Prevention].

Kardiologiia 2019 Apr 16;59(4):26-32. Epub 2019 Apr 16.

Republic Scientific and Practical Center "Cardiology", Minsk.

Purpose: to study frequency of progression of chronic heart failure (CHF), to develop multifactorial models for evaluation of risk of progression, and measures of non-drug secondary prevention of CHF.

Materials And Methods: We included in this study 531 patients with functional class (FC) I-III CHF (FC I - n=254, FC II - n=255, FC III - n=22). Examination included clinical-instrumental, clinical-functional, and laboratory (with determination of NT-proBNP concentration) investigations, use of the AUDIT and Morisky Green questionnaires. Read More

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https://lib.ossn.ru/jour/article/view/587
Publisher Site
http://dx.doi.org/10.18087/cardio.2019.4.10248DOI Listing
April 2019
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Religious and spiritual struggles, religiousness, and alcohol problems among undergraduates.

J Prev Interv Community 2019 Apr 19:1-16. Epub 2019 Apr 19.

b Bowling Green State University , Bowling Green , OH , USA.

Theoretically, religion/spirituality may protect against alcohol problems or facilitate recovery. However, challenges can arise in religious/spiritual life that may contribute to or complicate alcohol problems. Emerging adults often experience difficult transitions from family environments to independent membership in academic communities straddling the legal drinking age boundary. Read More

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https://www.tandfonline.com/doi/full/10.1080/10852352.2019.1
Publisher Site
http://dx.doi.org/10.1080/10852352.2019.1603678DOI Listing
April 2019
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Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases-An endoscopy cross-sectional study.

Kaohsiung J Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

This study examines the effects of environmental hazards, including tobacco, alcohol/alcohol flush response, areca nut, and Helicobacter pylori (H pylori) infection on upper digestive diseases. This is a multi-hospital-based endoscopy-survey cross-sectional study. Subjects were received upper endoscopies in outpatient clinics at four hospitals in Taiwan between 2008 and 2013. Read More

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http://dx.doi.org/10.1002/kjm2.12071DOI Listing

Origins of Catalyst Inhibition in the Manganese Catalysed Oxidation of Lignin Model Compounds with H2O2.

ChemSusChem 2019 Apr 19. Epub 2019 Apr 19.

university of Groningen, Nijenborgh 4, NETHERLANDS.

The upgrading of complex bio-renewable feedstock, such as lignocellulose, through depolymerisation benefits from the selective reactions at key functional groups. Applying homogeneous catalysts developed for selective organic oxidative transformations to complex feedstock such as lignin is challenged by the presence of interfering components. The selection of appropriate model compounds is essential in applying new catalytic systems and identifying such interferences. Read More

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http://dx.doi.org/10.1002/cssc.201900689DOI Listing
April 2019
2 Reads

Invited Commentary to "The Gastric Migration Crisis in Obesity Surgery".

Obes Surg 2019 Apr 17. Epub 2019 Apr 17.

Digestive Surgery Unit, Centre Hospitalier Universitaire de Guadeloupe, Pointe à Pitre, Guadeloupe, France.

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http://link.springer.com/10.1007/s11695-019-03873-w
Publisher Site
http://dx.doi.org/10.1007/s11695-019-03873-wDOI Listing
April 2019
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Comparative global metabolite profiling of xylose-fermenting Saccharomyces cerevisiae SR8 and Scheffersomyces stipitis.

Appl Microbiol Biotechnol 2019 Apr 19. Epub 2019 Apr 19.

School of Food Science and Biotechnology, Kyungpook National University, Daegu, Korea.

Bioconversion of lignocellulosic biomass into ethanol requires efficient xylose fermentation. Previously, we developed an engineered Saccharomyces cerevisiae strain, named SR8, through rational and inverse metabolic engineering strategies, thereby improving its xylose fermentation and ethanol production. However, its fermentation characteristics have not yet been fully evaluated. Read More

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http://link.springer.com/10.1007/s00253-019-09829-5
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http://dx.doi.org/10.1007/s00253-019-09829-5DOI Listing
April 2019
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Cervical Discogenic Pain Treatment with Percutaneous Jellified Ethanol: Preliminary Experience.

Authors:
Haytham Eloqayli

Biomed Res Int 2019 13;2019:2193436. Epub 2019 Mar 13.

Department of Neurosurgery, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid 22110, Jordan.

Background: Percutaneous DiscoGel® (Gelscom SAS, France), introduced in 2007 as a promising new minimal invasive technique, showed efficacy and safety in lumbar spine surgery, with limited use and scientific reports with regard to the cervical spine. Since the first publication of its use on the cervical spine (2010), less than 100 cases have been published. We introduce an initial experience with this relatively new procedure. Read More

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https://www.hindawi.com/journals/bmri/2019/2193436/
Publisher Site
http://dx.doi.org/10.1155/2019/2193436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436363PMC
March 2019
1 Read

Liquid Biphasic Electric Partitioning System as a Novel Integration Process for Betacyanins Extraction From Red-Purple Pitaya and Antioxidant Properties Assessment.

Front Chem 2019 3;7:201. Epub 2019 Apr 3.

Bioseparation Research Group, Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Malaysia.

Nowadays, downstream bioprocessing industries inclines towards the development of a green and high efficient bioseparation technology. Betacyanins are presently gaining higher interest in the food science as driven by their high tinctorial strength and health promoting functional properties. In this study, a novel green integration process of liquid biphasic electric partitioning system (LBEPS) was proposed for betacyanins extraction from peel and flesh of red-purple pitaya. Read More

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https://www.frontiersin.org/article/10.3389/fchem.2019.00201
Publisher Site
http://dx.doi.org/10.3389/fchem.2019.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456687PMC
April 2019
2 Reads

Clonazepam-induced liver dysfunction, severe hyperlipidaemia, and hyperglycaemic crisis: A case report.

SAGE Open Med Case Rep 2019 8;7:2050313X19842976. Epub 2019 Apr 8.

Clinical Research Center, Department of Medicine, International University of Health and Welfare, Tokyo, Japan.

In this study, we report a case of a 50-year-old Japanese man who had chronic whiplash-associated disorder, hyperlipidaemia, hyperuricacidaemia, and mild liver dysfunction due to excessive alcohol intake. Recently, he developed mild tremor in his left hand. Initiation of clonazepam (0. Read More

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http://dx.doi.org/10.1177/2050313X19842976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454642PMC
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