7,479 results match your criteria Alcohol and Substance Abuse Evaluation

Analysis of global prevalence of mental and substance use disorders within countries: focus on sociodemographic characteristics and income levels.

Int Rev Psychiatry 2022 Feb 19;34(1):6-15. Epub 2022 Feb 19.

Department of Mental Health & Cultural Diversity, IoPPN, Kings College, London, UK.

This report presents the prevalence of mental and substance use disorders around the world discussing the impact of geographical, sociodemographic, and income characteristics on national epidemiological differences. We analysed data from the Institute of Health Metrics and Evaluation database published in 2019. The global prevalence of mental disorders was 13. Read More

View Article and Full-Text PDF
February 2022

An empirical evaluation of alternative approaches to adjusting for attrition when analyzing longitudinal survey data on young adults' substance use trajectories.

Int J Methods Psychiatr Res 2022 May 18:e1916. Epub 2022 May 18.

Center for the Study of Drugs, Alcohol, Smoking and Health, Department of Health Behavior and Biological Sciences, School of Nursing, University of Michigan, Ann Arbor, Michigan, USA.

Objectives: Longitudinal survey data allow for the estimation of developmental trajectories of substance use from adolescence to young adulthood, but these estimates may be subject to attrition bias. Moreover, there is a lack of consensus regarding the most effective statistical methodology to adjust for sample selection and attrition bias when estimating these trajectories. Our objective is to develop specific recommendations regarding adjustment approaches for attrition in longitudinal surveys in practice. Read More

View Article and Full-Text PDF

The effect of inpatient addiction screening and intervention on readmissions.

Appl Nurs Res 2022 Jun 19;65:151573. Epub 2022 Mar 19.

Department of Psychiatry, Morristown Medical Center, United States of America.

Aim: The number of individuals in the United States (US) needing treatment for substance use disorder (SUD) but not receiving treatment at a specialty facility was reported to be almost 18 million in 2019. This study measured the difference in subsequent hospital visits between groups, one receiving screening, brief intervention, and referral to treatment (SBIRT) and one receiving usual care.

Background: There are studies that discuss SBIRT in terms of process evaluation, staff training, reduced readmission rates, and self-reported reductions in substance use. Read More

View Article and Full-Text PDF

Less time spent walking and depressive symptoms are associated with more self-perceived disability in primary care patients: a cross-sectional study from Uganda.

Pan Afr Med J 2022 3;41:173. Epub 2022 Mar 3.

KU Leuven Department of Rehabilitation Sciences, Leuven, Belgium.

Introduction: evidence on associations between self-perceived disability and physical activity levels in primary care patients (PCP) in low-income countries is absent. We investigated whether self-perceived disability is associated with physical activity levels while taking into account relevant demographic, social, mental and health parameters and other lifestyle factors in PCP in Uganda.

Methods: in this cross-sectional study, patients from two primary care centers in a farming community in central Uganda completed the World Health Organization Disability Assessment Schedule 2 (WHODAS 2), Simple Physical Activity Questionnaire (SIMPAQ), Patient Health Questionnaire-9 (PHQ-9), Alcohol Use Disorders Identification Test, and Multidimensional Scale for Perceived Social Support. Read More

View Article and Full-Text PDF

Closed doors: Predictors of stress, anxiety, depression, and PTSD during the onset of COVID-19 pandemic in Brazil.

J Affect Disord 2022 May 13;310:441-451. Epub 2022 May 13.

Postgraduate Program in Psychiatry and Medical Psychology, Federal University of São Paulo, São Paulo, Brazil; Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.

Background: The rise in mental health problems in the population directly or indirectly because of the coronavirus disease 2019 (COVID-19) pandemic is a major concern. The aim of this study was to investigate and compare independent predictors of symptoms of stress, anxiety, depression, and posttraumatic stress disorder (PTSD) in Brazilians one month after the implementation of measures of social distancing.

Methods: This cross-sectional study was performed using a web-based survey. Read More

View Article and Full-Text PDF

Evaluation of Trends in Alcohol Use Disorder-Related Mortality in the US Before and During the COVID-19 Pandemic.

JAMA Netw Open 2022 May 2;5(5):e2210259. Epub 2022 May 2.

Department of Infectious Diseases, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

View Article and Full-Text PDF

Protective effects of E Se tea extracts against alcoholic fatty liver disease induced by high fat/alcohol diet: In vivo biological evaluation and molecular docking study.

Phytomedicine 2022 Jul 25;101:154113. Epub 2022 Apr 25.

Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, China. Electronic address:

Background: With the development of economy and increased workload, chronic a high-fat/alcohol diet intake may lead to alcoholic fatty liver disease (AFLD), which is considered as a crucial health problem worldwide. E Se tea is produced of the leaves and leaf buds of Malus toringoides (Rehd.) Hughes in Tibet and has human health benefits with anti-hyperglycemia, hypertension, and hyperlipidemia effects. Read More

View Article and Full-Text PDF

Behavioral activation for depression delivered by drug and alcohol treatment workers: A pilot randomized controlled trial.

J Subst Abuse Treat 2022 Mar 24:108769. Epub 2022 Mar 24.

Department of Psychology, University of Sheffield, UK.

Background: One in two patients seeking help for substance use disorders (SUDs) has clinically significant depression symptoms. This co-occurrence impairs treatment outcomes, but limited evaluation of the implementation of evidence-based interventions has taken place.

Methods: This pilot randomized controlled trial (RCT) assessed the feasibility and potential efficacy of a brief, protocol-driven behavioral activation (BA) intervention delivered by drug and alcohol workers in a community drug and alcohol treatment (CDAT) service. Read More

View Article and Full-Text PDF

Are There Neural Overlaps of Reactivity to Illegal Drugs, Tobacco, and Alcohol Cues? With Evidence From ALE and CMA.

Front Psychiatry 2022 6;13:779239. Epub 2022 Apr 6.

Department of Psychology, Wenzhou Medical University, Wenzhou, China.

Abuses of most illegal drugs, including methamphetamine, marijuana, cocaine, heroin, and polydrug, are usually in conjunction with alcohol and tobacco. There are similarities and associations between the behavior, gene, and neurophysiology of such abusers, but the neural overlaps of their cue-reactivity and the correlation of neural overlap with drug craving still needs to be further explored. In this study, an Activation Likelihood Estimation (ALE) was performed on brain activation under legal (tobacco, alcohol) and illegal drug cues, for identifying the similarities in brain functions between different craving states. Read More

View Article and Full-Text PDF

An adaptive design to screen, treat, and retain people with opioid use disorders who use methamphetamine in methadone clinics (STAR-OM): study protocol of a clinical trial.

Trials 2022 Apr 23;23(1):342. Epub 2022 Apr 23.

Center for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, Los Angeles, USA.

Background: Methamphetamine use could jeopardize the current efforts to address opioid use disorder and HIV infection. Evidence-based behavioral interventions (EBI) are effective in reducing methamphetamine use. However, evidence on optimal combinations of EBI is limited. Read More

View Article and Full-Text PDF

Evaluation of an emergency safe supply drugs and managed alcohol program in COVID-19 isolation hotel shelters for people experiencing homelessness.

Drug Alcohol Depend 2022 Jun 7;235:109440. Epub 2022 Apr 7.

North End Community Health Centre, Halifax, Nova Scotia, Canada; Department of Family Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; Direction 180, Halifax, Nova Scotia, Canada.

Background: During a COVID-19 outbreak in the congregate shelter system in Halifax, Nova Scotia, Canada, a healthcare team provided an emergency "safe supply" of medications and alcohol to facilitate isolation in COVID-19 hotel shelters for residents who use drugs and/or alcohol. We aimed to evaluate (a) substances and dosages provided, and (b) outcomes of the program.

Methods: We reviewed medical records of all COVID-19 isolation hotel shelter residents during May 2021. Read More

View Article and Full-Text PDF

Alcohol consumption and lower risk of cardiovascular and all-cause mortality: the impact of accounting for familial factors in twins.

Psychol Med 2022 Apr 20:1-9. Epub 2022 Apr 20.

Norwegian Institute of Public Health, P.O. box 222 Skøyen, 0213Oslo, Norway.

Background: A moderate to high alcohol consumption is associated with a lower risk of cardiovascular disease (CVD) mortality in comparison with low consumption. The mechanisms underlying this association are not clear and have been suggested to be caused by residual confounding. The main objective of this study was to separate the familial and individual risk for CVD mortality and all-cause mortality related to alcohol consumption. Read More

View Article and Full-Text PDF

Health harms of non-medical prescription opioid use: A systematic review.

Drug Alcohol Rev 2022 May 18;41(4):941-952. Epub 2022 Apr 18.

Department of Epidemiology, Brown University School of Public Health, Providence, USA.

Issues: Non-medical prescription opioid use (NMPOU) contributes substantially to the global burden of morbidity. However, no systematic assessment of the scientific literature on the associations between NMPOU and health outcomes has yet been undertaken.

Approach: We undertook a systematic review evaluating health outcomes related to NMPOU based on ICD-10 clinical domains. Read More

View Article and Full-Text PDF

Alcoholic Hepatitis: Diagnosis and Management.

Am Fam Physician 2022 04;105(4):412-420

Wake Forest School of Medicine, Winston-Salem, NC, USA.

Alcoholic hepatitis is a clinical syndrome characterized by acute-onset jaundice and liver enzyme abnormalities in the setting of long-term heavy alcohol use. High rates of concomitant infections, systemic inflammation, and multiorgan failure lead to significant morbidity and mortality. Diagnosis of alcoholic hepatitis is primarily clinical, based on a consensus definition from the National Institute on Alcohol Abuse and Alcoholism. Read More

View Article and Full-Text PDF

Artificial intelligence to identify harmful alcohol use after early liver transplant for alcohol-associated hepatitis.

Am J Transplant 2022 Apr 13. Epub 2022 Apr 13.

University of Southern California Keck School of Medicine, Los Angeles, California, USA.

Early liver transplantation (LT) for alcohol-associated hepatitis (AH) is the fastest growing indication for LT, but prediction of harmful alcohol use post-LT remains limited. Among 10 ACCELERATE-AH centers, we examined psychosocial evaluations from consecutive LT recipients for AH from 2006 to 2017. A multidisciplinary panel used content analysis to develop a maximal list of psychosocial variables. Read More

View Article and Full-Text PDF

ON-ICE trial: Investigation of the combined effects of oxytocin and naltrexone on stress-induced and alcohol cue-induced craving in alcohol use disorder-Study protocol of a phase II randomised double-blind placebo-controlled parallel-group trial.

BMJ Open 2022 Apr 11;12(4):e059672. Epub 2022 Apr 11.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany.

Introduction: Although alcohol dependence (AD) is highly prevalent, only few medications are approved for its treatment. While currently approved medications, such as naltrexone (NTX), reduce craving and relapse risk to a certain extent, new approaches are needed to complement these pharmaca. One potential compound is oxytocin (OXY), which proved beneficial effects on alcohol craving and stress reactivity in preliminary clinical studies and synergism with NTX effects. Read More

View Article and Full-Text PDF

State-Level Prevalence and Associates of Opioid Dependence in the USA.

Int J Environ Res Public Health 2022 03 23;19(7). Epub 2022 Mar 23.

National Centre for Youth Substance Use Research, The University of Queensland, Brisbane 4067, Australia.

Traditionally, opioid-related disease burden was primarily due to heroin use. However, increases in extra-medical (or non-medicinal use of prescription opioids; NMPOs) use has precipitated the current overdose epidemic in North America. We aim to examine the state-level prevalence of heroin and NMPO dependence and their associations with opioid-related mortality and state-level socio-demographic profiles. Read More

View Article and Full-Text PDF

A Novel Morphine Drinking Model of Opioid Dependence in Rats.

Int J Mol Sci 2022 Mar 31;23(7). Epub 2022 Mar 31.

Center for Regenerative Medicine, Faculty of Medicine Clínica Alemana, Universidad del Desarrollo, Santiago 7610658, Chile.

An animal model of voluntary oral morphine consumption would allow for a pre-clinical evaluation of new treatments aimed at reducing opioid intake in humans. However, the main limitation of oral morphine consumption in rodents is its bitter taste, which is strongly aversive. Taste aversion is often overcome by the use of adulterants, such as sweeteners, to conceal morphine taste or bitterants in the alternative bottle to equalize aversion. Read More

View Article and Full-Text PDF

[Anhedonia as target symptom in personalized therapy of patients with mood disorders and alcohol use disorder comorbidity].

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(3):92-97

Mental Health Research Institute - Tomsk National Research Medical Center of Russian Academy Sciences, Tomsk, Russia.

Objective: To estimate the efficacy of antidepressants in the treatment of anhedonia in mood disorders (MD) comorbid with alcohol use disorder (AUD), considering melatonin concentration in the patient's blood serum.

Material And Methods: Seventy patients, aged 18-65 years old, with MD, including patients with- (group F3+F10, =36) or without comorbid AUD (group F3, =34), were examined. Control group consisted of 26 healthy volunteers. Read More

View Article and Full-Text PDF

eHealth Interventions to Address HIV and Other Sexually Transmitted Infections, Sexual Risk Behavior, Substance Use, and Mental Ill-health in Men Who Have Sex With Men: Systematic Review and Meta-analysis.

JMIR Public Health Surveill 2022 Apr 6;8(4):e27061. Epub 2022 Apr 6.

London School of Hygiene and Tropical Medicine, London, United Kingdom.

Background: Men who have sex with men experience disproportionately high levels of HIV and other sexually transmitted infections (STIs), sexual risk behavior, substance use, and mental ill-health. These experiences are interrelated, and these interrelations are potentiated by structural conditions of discrimination, stigma, and unequal access to appropriate health services, and they magnify each other and have intersecting causal pathways, worsening both risk for each condition and risk for the negative sequelae of each condition. eHealth interventions could address these issues simultaneously and thus have wide-ranging and greater effects than would be for any 1 outcome alone. Read More

View Article and Full-Text PDF

Biomarkers and Clinical Laboratory Detection of Acute and Chronic Ethanol Use.

Clin Chem 2022 May;68(5):635-645

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO.

Background: Ethanol use can lead to many health and socio-economic problems. Early identification of risky drinking behaviors helps provide timely clinical and social interventions. Laboratory testing of biomarkers of ethanol use supports the timely identification of individuals with risky drinking behaviors. Read More

View Article and Full-Text PDF

Stroke and Risk of Mental Disorders Compared With Matched General Population and Myocardial Infarction Comparators.

Stroke 2022 Mar 23:STROKEAHA121037740. Epub 2022 Mar 23.

Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Denmark (N.S., K.A., E.H.-P., K.J.R., V.W.H., H.T.S.).

Background: Accurate estimates of risks of poststroke outcomes from large population-based studies can provide a basis for public health policy decisions. We examined the absolute and relative risks of a spectrum of incident mental disorders following ischemic stroke and intracerebral hemorrhage.

Methods: During 2004 to 2018, we used Danish registries to identify patients (≥18 years and with no hospital history of mental disorders), with a first-time ischemic stroke (n=76767) or intracerebral hemorrhage (n=9344), as well as age-,sex-, and calendar year-matched general population (n=464 840) and myocardial infarction (n=92 968) comparators. Read More

View Article and Full-Text PDF

Model-based meta-analysis of salbutamol pharmacokinetics and practical implications for doping control.

CPT Pharmacometrics Syst Pharmacol 2022 04 22;11(4):469-481. Epub 2022 Mar 22.

Service of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Salbutamol was included in the prohibited list of the World Anti-Doping Agency (WADA) in 2004. Although systemic intake is banned, inhalation for asthma is permitted but with dosage restrictions. The WADA established a urinary concentration threshold to distinguish accordingly prohibited systemic self-administration from therapeutic prescription by inhalation. Read More

View Article and Full-Text PDF

The Management of Substance Use Disorders: Synopsis of the 2021 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.

Ann Intern Med 2022 May 22;175(5):720-731. Epub 2022 Mar 22.

Informatics, Decision-Enhancement, and Analytic Sciences Center (IDEAS), VA Salt Lake City Healthcare System, and Program for Addiction Research, Clinical Care, Knowledge, and Advocacy (PARCKA), University of Utah, Salt Lake City, Utah (A.J.G.).

Description: In August 2021, leadership within the U.S. Department of Veterans Affairs (VA) and U. Read More

View Article and Full-Text PDF

Pseudoresistance in idiopathic/genetic generalized epilepsies - Definitions, risk factors, and outcome.

Epilepsy Behav 2022 May 17;130:108633. Epub 2022 Mar 17.

Department of Neurology, Odense University Hospital, Denmark; Department of Clinical Research, University of Southern Denmark, Denmark; OPEN, Open Patient Data Explorative Network, Odense University Hospital, Odense, Denmark. Electronic address:

Objective: The aim of the study was to determine risk factors associated with pseudoresistance in a large, representative cohort of patients with Idiopathic/Genetic Generalized Epilepsy (IGE) and the impact of pseudoresistance on socioeconomic parameters.

Methods: We performed a literature review on definitions of pseudoresistance in IGE. In an established cohort of patients with IGE from Funen, patients with current or previous pseudoresistant seizures were retrospectively identified based on a comprehensive evaluation of the patients' medical records and direct patient contact, if required. Read More

View Article and Full-Text PDF

Postresidency Impact of Alcohol and Drug Screening and Intervention Training.

Fam Med 2022 03;54(3):200-206

Augusta University, Augusta, GA.

Background And Objectives: Many residency programs provide alcohol and drug screening, brief intervention (BI), and referral to treatment (SBIRT) training, hoping to impact residents' future practice activities. Little is known about postresidency use of these skills. This study assesses postresidency impact of SBIRT training. Read More

View Article and Full-Text PDF

Construct validity of the Cigarette Ratings Scale and associations with tobacco use and product feature outcomes.

Drug Alcohol Depend 2022 05 8;234:109397. Epub 2022 Mar 8.

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; University of Pennsylvania-Rutgers University Tobacco Center of Regulatory Science, Philadelphia, PA, USA; Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA, USA.

Background: Subjective ratings are inconsistently associated with behavioral outcomes such as tobacco use and there is no current standard. The Cigarette Ratings Scale is an ideal measure for further evaluation because it has been widely used in tobacco regulatory science and tobacco industry research.

Purpose: This study investigated the construct validity of the Cigarette Ratings Scale and associations with tobacco use and product feature outcomes. Read More

View Article and Full-Text PDF

Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES.

Nutrients 2022 Jan 27;14(3). Epub 2022 Jan 27.

Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland.

Trace element accumulation varies in different human tissues. Distribution of several elements was found to be disrupted in the case of excessive alcohol consumption, causing negative effects and exacerbation of pathological processes in the liver. In this study, we analyzed the levels and interactions between seven trace elements including calcium (Ca), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), potassium (K), and magnesium (Mg), manganese (Mn), sodium (Na), zinc (Zn), and selenium (Se) in individuals with alcohol-use disorder (AUD) and patients without AUD (control group). Read More

View Article and Full-Text PDF
January 2022

Examining the role of trauma in alcohol interlock performance: A structural pathway analysis.

Traffic Inj Prev 2022 9;23(4):153-158. Epub 2022 Mar 9.

Pacific Institute for Research and Evaluation, Beltsville, Maryland.

Objective: Self-medication using alcohol is a common coping response among individuals dealing with trauma as is driving under the influence of alcohol (DUI). A common intervention for drivers convicted of DUI, is an alcohol ignition interlock device (IID)-which requires breath samples before starting the car. If the sample is above a predetermined limit (. Read More

View Article and Full-Text PDF