7,091 results match your criteria Alcohol and Substance Abuse Evaluation

Early Complications Following Articular Calcaneus Fracture Repair: Evaluation of Open Versus Percutaneous Techniques.

OTA Int 2019 Dec 20;2(4):e049. Epub 2019 Dec 20.

Department of Orthopaedic Surgery, MetroHealth Medical Center, Affiliated with Case Western Reserve University, Cleveland, OH.

Objectives: To assess complications and secondary operations in patients treated with either open reduction and internal fixation (ORIF) versus percutaneous fixation of displaced intra-articular calcaneus fractures.

Design: Retrospective comparative study.

Setting: Level 1 trauma center. Read More

View Article and Full-Text PDF
December 2019

ADHD symptoms as risk factor for PTSD in inpatients treated for alcohol use disorder.

Psychiatry Res 2021 Mar 31;300:113904. Epub 2021 Mar 31.

Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Brumunddal, Norway; Institute of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway; Norwegian Institute of Public Health, Oslo, Norway.

Attention deficit hyperactivity disorder (ADHD) and post-traumatic stress disorder (PTSD) are more common in alcohol use disorder (AUD) patients than in the general population. Still, there is a lack of knowledge about the relationship between the two conditions in these patients. The main objective of this study was to examine the prevalence of ADHD symptoms, and the relationship between ADHD symptoms and PTSD in AUD inpatients in treatment. Read More

View Article and Full-Text PDF

Incidence of Access to Ambulatory Mental Health Care Prior to a Psychiatric Emergency Department Visit Among Adults in Ontario, 2010-2018.

JAMA Netw Open 2021 Apr 1;4(4):e215902. Epub 2021 Apr 1.

ICES, Toronto, Ontario, Canada.

Importance: Psychiatric emergency department (ED) visits may be avoidable if individuals have access to adequate outpatient care, but the extent to which individuals use the ED itself as a key point of access is largely unknown.

Objective: To describe the extent to which the ED is a first point of contact for mental health care among adults, and identify key factors associated with this outcome.

Design, Setting, And Participants: This cohort study was conducted from 2010 to 2018 in Ontario, Canada. Read More

View Article and Full-Text PDF

Quantifying opioid use disorder Cascade of Care outcomes in an American Indian tribal nation in Minnesota.

Drug Alcohol Depend 2021 May 18;222:108661. Epub 2021 Mar 18.

University of Minnesota Medical School, Duluth Campus, 1035 University Dr, Duluth, MN, 55812, United States.

American Indian communities in Minnesota have been disproportionately impacted by the opioid use disorder (OUD) epidemic, which tribal communities have taken numerous steps to address. The Cascade of Care is a public health framework for measuring population-level OUD risk, treatment engagement, treatment retention, and recovery outcomes, which can help communities monitor the impact of responses to the OUD epidemic and identify where treatment- and recovery-related barriers and facilitators may exist. However, no studies have quantified the Cascade of Care stages within tribal communities and the extent to which these stages can be quantified using existing data sources is unknown. Read More

View Article and Full-Text PDF

Socially-supportive norms and mutual aid of people who use opioids: An analysis of Reddit during the initial COVID-19 pandemic.

Drug Alcohol Depend 2021 05 18;222:108672. Epub 2021 Mar 18.

Center for Opioid Epidemiology and Policy, Department of Population Health, NYU Grossman School of Medicine, United States.

Background: Big events (i.e., unique historical disruptions) like the COVID-19 epidemic and its associated period of social distancing can transform social structures, social interactions, and social norms. Read More

View Article and Full-Text PDF

The who, the what, and the how: A description of strategies and lessons learned to expand access to medications for opioid use disorder in rural America.

Subst Abus 2021 Mar 9:1-7. Epub 2021 Mar 9.

Department of Psychiatry and Behavioral Sciences, University of New Mexico, Albuquerque, NM, USA.

Access to treatment for opioid use disorder (OUD) in rural areas within the United States remains a challenge. Providers must complete 8-24 h of training to obtain the Drug Addiction Treatment Act (DATA) 2000 waiver to have the legal authority to prescribe buprenorphine for OUD. Over the last 4 years, we executed five dissemination and implementation grants funded by the Agency for Healthcare Research and Quality to study and address barriers to providing Medications for Opioid Use Disorder Treatment (MOUD), including psychosocial supports, in rural primary care practices in different states. Read More

View Article and Full-Text PDF

Readiness to provide medications for opioid, alcohol and tobacco use disorder in HIV clinics: A multi-site mixed-methods formative evaluation.

J Acquir Immune Defic Syndr 2021 Feb 26. Epub 2021 Feb 26.

Program in Addiction Medicine, Yale School of Medicine, New Haven, CT Department of Internal Medicine, Yale School of Medicine, New Haven, CT Center for Interdisciplinary Research on AIDS, Yale School of Public Health, New Haven, CT Yale Center for Analytic Sciences, Yale School of Public Health, New Haven, CT Department of Emergency Medicine, Yale School of Medicine, New Haven, CT Department of Biostatistics, Yale School of Public Health, New Haven, CT Department of Medicine, Brown University, Providence, RI Institute for Collaboration on Health, Intervention, and Policy (InCHIP), University of Connecticut, Storrs, CT SUNY Downstate, Brooklyn, NY Department of Psychiatry, Yale School of Medicine, New Haven, CT.

Background: We sought to characterize readiness, barriers to and facilitators of providing medications for addiction treatment (MAT) in HIV clinics.

Setting: Four HIV clinics in the US northeast.

Methods: Mixed-methods formative evaluation conducted June 2017-February 2019. Read More

View Article and Full-Text PDF
February 2021

Assessment of Annual Cost of Substance Use Disorder in US Hospitals.

JAMA Netw Open 2021 03 1;4(3):e210242. Epub 2021 Mar 1.

National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.

Importance: A persistently high US drug overdose death toll and increasing health care use associated with substance use disorder (SUD) create urgency for comprehensive estimates of attributable direct costs, which can assist in identifying cost-effective ways to prevent SUD and help people to receive effective treatment.

Objective: To estimate the annual attributable medical cost of SUD in US hospitals from the health care payer perspective.

Design, Setting, And Participants: This economic evaluation of observational data used multivariable regression analysis and mathematical modeling of hospital encounter costs, controlling for patient demographic, clinical, and insurance characteristics, and compared encounters with and without secondary SUD diagnosis to statistically identify the total attributable cost of SUD. Read More

View Article and Full-Text PDF

A systematic review of evidence-based practice implementation in drug and alcohol settings: applying the consolidated framework for implementation research framework.

Implement Sci 2021 Mar 4;16(1):22. Epub 2021 Mar 4.

Sydney School of Medicine, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.

Background: There is a paucity of translational research programmes to improve implementation of evidence-based care in drug and alcohol settings. This systematic review aimed to provide a synthesis and evaluation of the effectiveness of implementation programmes of treatment for patients with drug and alcohol problems using the Consolidated Framework for Implementation Research (CFIR).

Methods: A comprehensive systematic review was conducted using five online databases (from inception onwards). Read More

View Article and Full-Text PDF

Adolescent Substance Abuse, Transgenerational Consequences and Epigenetics.

Curr Neuropharmacol 2021 Mar 3. Epub 2021 Mar 3.

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran. Iran.

Adolescence is the transitional period between childhood and adulthood and a critical period in brain development. Adolescence in humans is also associated with increased expression of risk-taking behaviors. Epidemiological and clinical studies, for example, show a surge of drug abuse and raise the hypothesis that the adolescent brain undergoes critical changes resulting in diminished control. Read More

View Article and Full-Text PDF

Preliminary Results of Doctoral Dissertation: Empirical Review of EMDR in the Process of Hospital Treatment of Opiates Addicts.

Sedin Habibović

Psychiatr Danub 2021 Feb;33(Suppl 1):29-32

Public Health Institution for addictions of Zenica-Doboj Canton, 72000 Zenica, Bosnia and Herzegovina,

Introduction: Use of EMDR in work with addicts is described mainly through case studies, and Hase, Schallmayer and Sack (2008) examined experimentally effect of EMDR in the treatment of alcohol addicts and found a significant decrease of cravings for addicts who had , next to the standard treatment, also EMDR therapy, compared to a group that had only standard treatment. To examine efficiency of EMDR therapy in the treatment of opiates addicts.

Subjects And Methods: In research is applied group experimental scheme with a control group and measurement before and after treatment and six months after treatment. Read More

View Article and Full-Text PDF
February 2021

A two-component intervention to improve hand hygiene practices and promote alcohol-based hand rub use among people who inject drugs: a mixed-methods evaluation.

BMC Infect Dis 2021 Feb 25;21(1):211. Epub 2021 Feb 25.

Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.

Background: Inconsistent hand hygiene puts people who inject drugs (PWID) at high risk of infectious diseases, in particular skin and soft tissue infections. In healthcare settings, handwashing with alcohol-based hand rubs (ABRH) is recommended before aseptic procedures including intravenous injections. We aimed to evaluate the acceptability, safety and preliminary efficacy of an intervention combining ABHR provision and educational training for PWID. Read More

View Article and Full-Text PDF
February 2021

Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder.

Drug Alcohol Depend 2021 Apr 15;221:108614. Epub 2021 Feb 15.

Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT, 06511, USA; Clinical Neuroscience Research Unit, Connecticut Mental Health Center, 34 Park Street, New Haven, CT, 06519, USA.

Background: Preclinical rodent studies have demonstrated reduced cocaine taking after administration of glucagon-like peptide 1 (GLP-1) analogues. We investigated effects of a GLP-1 analogue (exenatide) on behavioral and subjective effects of cocaine in individuals with cocaine use disorder (CUD).

Methods: Non-treatment-seeking CUD subjects underwent two human laboratory cocaine self-administration test sessions following an acute 3 -h pre-treatment with exenatide (5 mcg; subcutaneously) or placebo. Read More

View Article and Full-Text PDF

Personal and professional attitudes associated with nurses' motivation to work with patients with opioid use and opioid use-related problems.

Subst Abus 2021 Feb 22:1-22. Epub 2021 Feb 22.

Health and Community Systems, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA.

Background: Opioid use and opioid use-related problems contribute significantly to increased morbidity rates and premature deaths as well as an increased economic burden. Nurses have key roles in providing care to this patient population; however, they often report low motivation toward working with these patients. Examining personal and professional attitudes associated with nurses' motivation to work with this population can present a valuable opportunity to enhance their willingness to intervene at an earlier stage when patients do not have a diagnosable opioid use disorder. Read More

View Article and Full-Text PDF
February 2021

Promising vulnerability markers of substance use and misuse: A review of human neurobehavioral studies.

Neuropharmacology 2021 04 16;187:108500. Epub 2021 Feb 16.

Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, USA.

Substance use often begins, and noticeably escalates, during adolescence. Identifying predictive neurobehavioral vulnerability markers of substance use and related problems may improve targeted prevention and early intervention initiatives. This review synthesizes 44 longitudinal studies and explores the utility of developmental imbalance models and neurobehavioral addiction frameworks in predicting neural and cognitive patterns that are associated with prospective substance use initiation and escalation among young people. Read More

View Article and Full-Text PDF

Pacific peoples and alcohol: a review of the literature.

N Z Med J 2021 02 5;134(1529):86-96. Epub 2021 Feb 5.

Associate Professor, Social and Community Health, University of Auckland, Auckland, New Zealand.

Aim: To present a review of recent research exploring alcohol use by Pacific peoples in New Zealand. The review builds on a comprehensive narrative review of research and literature on Pacific peoples and alcohol use, Pearls Unlimited (2009).

Method: We conducted a scoping review of published and grey literature written and published between 2009 and 2019. Read More

View Article and Full-Text PDF
February 2021

Evaluation of the diagnostic utility of carbohydrate-deficient transferrin in chronic alcoholism: Results from Southwest China.

Medicine (Baltimore) 2021 Jan;100(4):e24467

Department of Laboratory Medicine.

Abstract: Although recent gathered evidence indicates that obtaining the diagnostic value of serum carbohydrate-deficient transferrin might be more useful for identifying alcohol abuse than other widely available biochemical tests; however, its precise value as an indicator of chronic alcoholism is unclear. The main objective is to investigate the diagnostic significance of carbohydrate-deficient transferrin in chronic alcoholism in the Chinese population.In this study, we enrolled (1) 52 physically healthy subjects, (2) 20 patients with nonalcoholic liver disease, and (3) 70 alcoholics. Read More

View Article and Full-Text PDF
January 2021

Surveillance by oral fluid of drugs subject to misuse among individuals under arrest.

Am J Drug Alcohol Abuse 2021 Mar 22;47(2):247-254. Epub 2021 Jan 22.

Forensic Fluids Laboratories Inc., Kalamazoo, MI, USA.

: Between 1988 and 2013 the U.S. government conducted surveillance of national drug misuse use trends by collecting voluntary urine specimens from individuals under arrest in major counties. Read More

View Article and Full-Text PDF

[Quality of treatment outcomes in alcohol- and substance-related disorders: an evaluation of inpatients from ten psychiatric hospitals].

Fortschr Neurol Psychiatr 2021 Apr 13;89(4):154-161. Epub 2021 Jan 13.

Vitos Klinik Hochtaunus.

Aim Of The Study: Alcohol and substance-related disorders (ICD 10 F1x.x) are among the most frequent diagnoses made in hospitalized patients requiring somatic and psychiatric care. In order to assess the success of treatment, it is important to establish and implement outcome indicators in practice. Read More

View Article and Full-Text PDF

Randomized controlled trials for alcohol use disorder during the COVID-19 pandemic.

Alcohol 2021 05 9;92:21-24. Epub 2021 Jan 9.

Center for Alcohol and Addiction Studies, Brown University Providence, RI, United States; Department of Behavioral and Social Sciences, School of Public Health, Brown University Providence, RI, United States; Department of Neuroscience, Brown University, Providence, RI, United States; Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, United States. Electronic address:

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) altered the logistics of ongoing randomized controlled trials (RCTs). The need to reduce in-person research and clinical activities, however, presented an additional level of complexity in order to continue conducting RCTs that focused on the development of medications for Alcohol Use Disorder (AUD). The visits required a systematic objective evaluation from the physician and mental health professional and clinical staff, as many of the safety and efficacy assessments are self-reported. Read More

View Article and Full-Text PDF

Detection of synthetic cannabinoid adulteration in the unregulated drug supply in three Canadian settings.

Drug Alcohol Rev 2021 May 22;40(4):580-585. Epub 2020 Dec 22.

Centre on Drug Policy Evaluation, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

Introduction: Novel psychoactive substances (NPS) are increasingly being consumed worldwide, with synthetic cannabinoids and synthetic opioids being the second and third most commonly used NPS, respectively. Certain synthetic cannabinoids can produce significant harms, particularly when used with opioids. The objective of this study was to characterise the presence of synthetic cannabinoids in the unregulated drug supply in three Canadian settings METHODS: In the British Columbia setting, all samples were first analysed at point-of-care using combination Fourier-transform infrared (FTIR) spectroscopy and fentanyl immunoassay strips prior to confirmatory testing using quantitative nuclear magnetic resonance spectroscopy, gas chromatography/mass spectrometry (GC/MS) and/or liquid chromatography/mass spectrometry (LC/MS). Read More

View Article and Full-Text PDF

ASF (a Compound of Traditional Chinese Medicine) in the treatment of patients with alcohol dependence: Study protocol of a randomized, double-blinded, placebo-controlled clinical trial.

Medicine (Baltimore) 2020 Dec;99(52):e23899

Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: Alcohol dependence is one of the biggest problems facing public health worldwide. Currently, it is an under-diagnosed and under-treated disease. Even when given treatments for addiction withdrawal, over 2/3 of patients who have undergone abstinence-oriented treatment will relapse in the first year. Read More

View Article and Full-Text PDF
December 2020

Association of Bariatric Surgical Procedures With Changes in Unhealthy Alcohol Use Among US Veterans.

JAMA Netw Open 2020 12 1;3(12):e2028117. Epub 2020 Dec 1.

Kaiser Permanente Washington Health Research Institute, Seattle, Washington.

Importance: Bariatric surgical procedures have been associated with increased risk of unhealthy alcohol use, but no previous research has evaluated the long-term alcohol-related risks after laparoscopic sleeve gastrectomy (LSG), currently the most used bariatric procedure. No US-based study has compared long-term alcohol-related outcomes between patients who have undergone Roux-en-Y gastric bypass (RYGB) and those who have not.

Objective: To evaluate the changes over time in alcohol use and unhealthy alcohol use from 2 years before to 8 years after a bariatric surgical procedure among individuals with or without preoperative unhealthy alcohol use. Read More

View Article and Full-Text PDF
December 2020

Evaluation of Drug and Alcohol Abuse in People Aged 15 Years and Older in Iran.

Iran J Public Health 2020 Oct;49(10):1940-1946

Department of Sociology, University of Welfare, Tehran, Iran.

Background: Drug addiction is known as one of the health, medical and social problems of the present century. Beyond the harmful physical and mental consequences for addicts, drug abuse can cause serious social problems. The aim of this study was to evaluate drug and alcohol abuse in individuals aged 15 yr and over in Iran in 2015. Read More

View Article and Full-Text PDF
October 2020

Opioid-Related Emergency Department Visits and Access to Health Care--An Opportunity for Treatment Engagement.

Mir M Ali

J Stud Alcohol Drugs 2020 11;81(6):760-761

Office of the Assistant Secretary for Planning & Evaluation, U.S. Department of Health & Human Services, Washington, D.C.

View Article and Full-Text PDF
November 2020

Aims, development, and early results of an interdisciplinary primary care initiative to address patient vulnerabilities.

Am J Drug Alcohol Abuse 2021 Mar 10;47(2):160-169. Epub 2020 Dec 10.

Vulnerable Veteran Innovative PACT (VIP) Initiative; Informatics, Decision-Enhancement and Analytic Sciences (IDEAS) Center of Innovation, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.

Addressing substance use disorders and social determinants of poor health at a population level is a major national healthcare priority. One promising model to improve healthcare outcomes for patients with these conditions is the Vulnerable Veteran Innovative Patient-Aligned Care Team (PACT) Initiative, or VIP - an interdisciplinary, team-based primary care delivery model designed to address the needs of vulnerable patients in the Veterans Health Administration. VIP establishes a single, integrated primary care environment for the management of substance use disorders, mental illness, social determinants of poor health, and complexities in care resulting from the co-occurrence of these conditions. Read More

View Article and Full-Text PDF

Recovery opioid overdose team (ROOT) pilot program evaluation: A community-wide post-overdose response strategy.

Subst Abus 2020 Dec 7:1-5. Epub 2020 Dec 7.

Center for the Study of Drugs, Alcohol, Smoking and Health, University of Michigan School of Nursing, Ann Arbor, Michigan, USA.

Background: Effective interventions for overdose survivors are needed in the emergency departments (EDs). One promising model is the use of peer recovery coaches to engage with survivors in EDs, followed by partnering with community case management navigators to connect survivors to recovery support and treatment services. This paper describes the evaluation of a pilot program, the Recovery Opioid Overdose Team (ROOT), a warm hand-off system that links survivors to treatment services post-ED discharge. Read More

View Article and Full-Text PDF
December 2020

Recognition of a disulfiram ethanol reaction in the emergency department is not always straightforward.

PLoS One 2020 3;15(12):e0243222. Epub 2020 Dec 3.

Department of Emergency Medicine, Ghent University Hospital, Ghent, Belgium.

Objectives: Disulfiram is an adjunct in the treatment of alcohol use disorders, but case reports indicate that disulfiram ethanol reactions are not always recognized in the emergency department. Our first aim is to remind of this risk with two case reports of life-threatening reactions not immediately considered by the emergency physician. The second aim is to estimate the probability that a disulfiram reaction goes unrecognized with the use of a retrospective study of patients admitted to the emergency department. Read More

View Article and Full-Text PDF
January 2021