3,699 results match your criteria Alcohol and Alcoholism [Journal]


Lack of Association Between Serotonin Transporter Gene (SLC6A4) Promoter Methylation and Amygdala Response During Negative Emotion Processing in Individuals With Alcohol Dependence.

Alcohol Alcohol 2019 Apr 22. Epub 2019 Apr 22.

Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive (10CRC), Bethesda, MD 20892, USA.

Aims: Differences in DNA methylation of the serotonin transporter gene (SLC6A4) have been shown to alter SLC6A4 expression and predict brain functions in healthy individuals. This study investigated the association between SLC6A4 promoter methylation and threat-related amygdala activation in individuals with alcohol dependence (AD).

Methods: Methylation of the SLC6A4 promoter region was assessed using peripheral blood DNA from 45 individuals with AD and 45 healthy controls (HCs). Read More

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http://dx.doi.org/10.1093/alcalc/agz032DOI Listing

Assessment and Treatment of Patients with Comorbidity of Mental Health Problems and Alcohol Use Disorders: Experiences of Clinicians and Patients in the UK and Poland.

Alcohol Alcohol 2019 Apr 16. Epub 2019 Apr 16.

Department of Studies on Alcohol and Drug Dependence, Institute of Psychiatry and Neurology, Warsaw, Poland.

Aims: Treatment of patients with comorbidity of mental health problems and alcohol use disorder (AUD) constitutes a challenge in many countries. The article aimed at exploration of personal experiences of clinicians and patients with the comorbidity regarding its assessment, treatment and organization of care in Poland and the UK.

Methods: Data were collected via in-depth, semi-structured interviews with clinicians (N = 28) and patients (N = 81) in both countries, according to a unified study protocol. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/alcalc/agz023DOI Listing
April 2019
1 Read

Clinical Predictors of Response to Baclofen in the Treatment of Alcohol use Disorder: Results from the BacALD Trial.

Alcohol Alcohol 2019 Apr 12. Epub 2019 Apr 12.

NHMRC Centre of Research Excellence in Mental Health and Substance Use, Discipline of Addiction medicine, Central Clinical School, Faculty of Medicine and Health, University of Sydney, 2006 NSW, Australia.

Aim: To examine clinical predictors of treatment response to baclofen in patients with alcohol use disorder (AUD).

Methods: Data from a randomised controlled trial (RCT) (N = 104), in which AUD patients received placebo or baclofen (30 mg/day or 75 mg/day) for 12 weeks, were analysed to determine predictive effects of the following four clinical characteristics: alcoholic liver disease (ALD), baseline alcohol consumption, craving and anxiety. Treatment outcomes included: (i) time to lapse and (ii) time to relapse. Read More

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http://dx.doi.org/10.1093/alcalc/agz026DOI Listing

Elimination Characteristics of the Alcohol Biomarker Phosphatidylethanol (PEth) in Blood during Alcohol Detoxification.

Alcohol Alcohol 2019 Apr 10. Epub 2019 Apr 10.

Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

Aims: The study documented elimination characteristics of three phosphatidylethanol (PEth) homologs in serially collected blood samples from 47 heavy drinkers during ~2 weeks of alcohol detoxification at hospital.

Methods: Venous whole blood and urine samples were collected every 1-2 days during treatment. Concentrations of PEth, and of urinary ethyl glucuronide (EtG) and ethyl sulfate (EtS) to detect relapse drinking, were measured using liquid chromatography-tandem mass spectrometry. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/alcalc/agz027DOI Listing
April 2019
11 Reads

Association Between Alcoholic Cirrhosis and Hemorrhagic Stroke: A Nationwide Population-based Study.

Alcohol Alcohol 2019 Apr 8. Epub 2019 Apr 8.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taiwan.

Aims: This study investigated whether patients with alcoholic cirrhosis have a high risk of hemorrhagic stroke.

Methods: In this study, 17,094 patients diagnosed with cirrhosis between 2000 and 2010 were identified using the Taiwan National Health Insurance claims data. Identified patients were randomly selected and propensity score matched with individuals without cirrhosis according to age, sex, comorbidities and index year. Read More

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http://dx.doi.org/10.1093/alcalc/agz025DOI Listing
April 2019
1 Read

Effectiveness of Workplace Intervention for Reducing Alcohol Consumption: a Systematic Review and Meta-Analysis.

Alcohol Alcohol 2019 Apr 8. Epub 2019 Apr 8.

Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605008, India.

Aims: To review the effectiveness of workplace interventions in reducing alcohol consumption among employees.

Methods: Systematic search of science databases from inception till May 2018 for trials where an intervention was tested against a control and data presented as amount of alcohol consumed per week. Quality of trials was assessed by Cochrane risk of bias tool. Read More

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http://dx.doi.org/10.1093/alcalc/agz024DOI Listing

Problems with Methanol Poisoning Outbreaks in Iran.

Alcohol Alcohol 2019 Apr 8. Epub 2019 Apr 8.

Clinical Toxicology Department, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

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http://dx.doi.org/10.1093/alcalc/agz028DOI Listing

Predictors of Alcohol Use Disorders Among Young Adults: A Systematic Review of Longitudinal Studies.

Alcohol Alcohol 2019 Apr 3. Epub 2019 Apr 3.

The University of Queensland, Institute for Social Science Research, Level 2 Cycad Building (1018), 80 Meiers Road, Indooroopilly QLD 4068, Brisbane, Australia.

Aims: Alcohol use disorders (AUDs) are highly disabling neuropsychiatric conditions. Although evidence suggests a high burden of AUDs in young adults, few studies have investigated their life course predictors. It is crucial to assess factors that may influence these disorders from early life through adolescence to deter AUDs in early adulthood by tailoring prevention and intervention strategies. Read More

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http://dx.doi.org/10.1093/alcalc/agz020DOI Listing
April 2019
1 Read

Multisensory Environments to Measure Craving During Functional Magnetic Resonance Imaging.

Alcohol Alcohol 2019 Mar 28. Epub 2019 Mar 28.

Center for Alcohol and Addiction Studies, Department of Behavioral and Social Science, Brown University, Providence, RI, USA.

There are limited functional magnetic resonance imaging (fMRI) studies that measure alcohol craving with multisensory environments. Researchers are faced with a two-fold challenge: to recreate a naturalistic environment during an MRI scan and to produce paradigms that mimic real-life conditions involved with craving. Craving is a multifaceted psychological construct and techniques such as fMRI provide an alternative way to measure craving and to have a better understanding of its complexity. Read More

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http://dx.doi.org/10.1093/alcalc/agz021DOI Listing
March 2019
1 Read

Alcohol Hangover: Underlying Biochemical, Inflammatory and Neurochemical Mechanisms.

Alcohol Alcohol 2019 Mar 27. Epub 2019 Mar 27.

Department of Medicine, Imperial College London, London W12 0NN, UK.

Aim: To review current alcohol hangover research in animals and humans and evaluate key evidence for contributing biological factors.

Method: Narrative review with alcohol hangover defined as the state the day after a single episode of heavy drinking, when the alcohol concentration in the blood approaches zero.

Results: Many of the human studies of hangover are not well controlled, with subjects consuming different concentrations of alcohol over variable time periods and evaluation not blinded. Read More

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http://dx.doi.org/10.1093/alcalc/agz016DOI Listing

Sex Differences in Aversion-Resistant Ethanol Intake in Mice.

Alcohol Alcohol 2019 Mar 19. Epub 2019 Mar 19.

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Aims: Compulsive ethanol intake, characterized by persistent consumption despite negative consequences, is an addictive behavior identified by the DSM-5 as a central criterion in diagnosing alcohol use disorders (AUD). Epidemiological data suggest that females transition from recreational alcohol use to AUD more rapidly than males. Because of this potential sex difference in the etiology of AUD, it is critical to assess addictive behaviors such as compulsive intake in both males and females in preclinical studies. Read More

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http://dx.doi.org/10.1093/alcalc/agz022DOI Listing
March 2019
1 Read

Alcohol Screening and Brief Advice in NHS General Dental Practices: A Cluster Randomized Controlled Feasibility Trial.

Alcohol Alcohol 2019 Mar 18. Epub 2019 Mar 18.

Department of Epidemiology and Public Health, UCL, UK.

Aim: To assess the feasibility and acceptability of screening for alcohol misuse and delivering brief advice to eligible patients attending NHS dental practices in London.

Methods: A two-arm cluster randomized controlled feasibility trial was conducted. Twelve dental practices were recruited and randomized to intervention and control arms. Read More

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http://dx.doi.org/10.1093/alcalc/agz017DOI Listing
March 2019
1 Read

The Development of Video Messages to Reduce Binge Drinking: Focus Group Results.

Alcohol Alcohol 2019 Mar 12. Epub 2019 Mar 12.

Department of Psychology, University of Nevada, Reno, NV 89557, USA.

Aims: The current study examined college students' perceptions of loss framed and gain framed messages aimed at reducing binge drinking.

Methods: Using focus groups (n = 3) consisting of undergraduates (n = 131), an iterative process was undertaken to ensure the acceptability and construct validity of loss framed and gain framed video messages. Both quantitative and qualitative data were collected. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/alcalc/agz001DOI Listing
March 2019
15 Reads

Therapeutic Drug Monitoring and the Clinical Significance of Naltrexone Blood Levels at the Time of a First Drink: Relevance to the Sinclair Method.

Authors:
John C Umhau

Alcohol Alcohol 2019 Mar;54(2):192

Alcohol Recovery Medicine, 10804 Rock Run Drive, Potomac, MD 20854, USA, Fort Belvoir Community Hospital, Fort Belvoir, Virginia, United States, and Food and Drug Administration, Silver Spring, MD, United States.

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http://dx.doi.org/10.1093/alcalc/agz014DOI Listing
March 2019
1 Read

Soluble α-Klotho in Liver Cirrhosis and Alcoholism.

Alcohol Alcohol 2019 Mar 12. Epub 2019 Mar 12.

Servicio de Medicina Interna. Hospital Universitario de Canarias. Universidad de La Laguna. Tenerife, Canary Islands, Spain.

Aims And Background: Alpha Klotho is a transmembrane protein that serves as co-receptor for FGF23. Ectodomain of membrane bound α Klotho may be shed by membrane bound proteases (activated, among other factors, by tumor necrosis factor (TNF)-α) generating the soluble form of the protein (sKl) that functions as a hormone by itself. It modulates calcium influx into cells, blunts IGF-1/Insulin signaling, promotes synthesis of antioxidants, generally slows down tumor progression, delays cell senescence, is neuroprotective and promotes oligodendrocyte maturation and myelin synthesis, and muscle rejuvenation. Read More

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http://dx.doi.org/10.1093/alcalc/agz019DOI Listing
March 2019
1 Read

Dose-Response Relative Risk of Injury From Acute Alcohol Consumption in 22 Countries: Are Women at Higher Risk Than Men?

Alcohol Alcohol 2019 Mar 11. Epub 2019 Mar 11.

Pan American Health Organization, Washington, DC, USA.

Aims: The risk of injury from alcohol consumption was analyzed by gender, controlling for frequency of heavy drinking occasions, and by cause of injury (traffic, violence, fall, other).

Methods: Case-crossover analysis was conducted on 18,627 injured patients arriving at the emergency department (ED) within six hours of the event.

Findings: Risk of injury was similar for females and males at ≤3 drinks prior to injury (OR = 2. Read More

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http://dx.doi.org/10.1093/alcalc/agz018DOI Listing

Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians.

Alcohol Alcohol 2019 Mar 5. Epub 2019 Mar 5.

Department of Psychology, Syracuse University, 430 Huntington Hall, Syracuse, NY 13244, USA.

Aims: The current meta-analysis tested independent and composite associations of three commonly studied alcohol metabolism alleles with alcohol use disorder (AUD) within East Asians as well as characterized potential moderating factors in these associations.

Methods: For meta-analysis, 32 articles were selected that investigated ALDH2 (n = 17,755), ADH1B (n = 13,591) and ADH1C (n = 4,093) associations with AUD in East Asians.

Results And Conclusions: All three variants were associated with AUD across allelic and genotypic models: ALDH2, ORs = 0. Read More

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http://dx.doi.org/10.1093/alcalc/agz011DOI Listing
March 2019
2 Reads

Assessment of alcohol consumption in depression follow-up using self-reports and blood measures including inflammatory biomarkers.

Alcohol Alcohol 2019 Feb 27. Epub 2019 Feb 27.

Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Seinäjoki, Finland.

Aims: Alcohol consumption has been suggested a major role in the pathogenesis and prognosis of depression. However, reliable identification of hazardous drinking continues to be problematic. We compared the accuracy of different biomarkers and self-reports of alcohol consumption in the follow-up study of depression. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/alcalc/agz002DOI Listing
February 2019
10 Reads

Effects of Hyperbaric Oxygen Therapy on Brain Perfusion, Cognition and Behavior in Fetal Alcohol Spectrum Disorder-A Case Study.

Alcohol Alcohol 2019 Mar;54(2):177-179

Maccabi-Kahn Research Institute, Israel.

A 15-year-old girl diagnosed with FASD underwent 100 courses of hyperbasic oxygen therapy (HBOT). Prior to HBOT, single motion emission compute tomographic begin imaging (SPECT) revealed areas of hypo-perfusion bilaterally in the orbitofrontal region, temporal lobes and right dorsolateral-frontal, as well the medial aspect of the left cerebellum. Following two sets of HBOT treatments (60 plus 40), over 6 months, there was improvement in perfusion to the left cerebellum as well as the right frontal lobe. Read More

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http://dx.doi.org/10.1093/alcalc/agz009DOI Listing
March 2019
1 Read

Plus ça change, plus c'est la même chose: a Review of Recent Alcohol Policy Developments in Europe.

Authors:
Peter Rice

Alcohol Alcohol 2019 Mar;54(2):123-127

Steering Group Chair, Scottish Health Action on Alcohol Problems, Royal College of Physicians of Edinburgh, 12 Queen Street, Edinburgh, UK.

Aim: This paper briefly reviews the history of alcohol policy development in Europe leading to the current consensus in the health field on strategic priorities. There is a review of recent policy developments in selected European countries, both EU and non-EU members.

Methods: Narrative review of published journal articles, publications from WHO, and other health organisations and government publications. Read More

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http://dx.doi.org/10.1093/alcalc/agz013DOI Listing
March 2019
2.889 Impact Factor

Ethyl Glucuronide as a Long-term Alcohol Biomarker in Fingernail and Hair. Matrix Comparison and Evaluation of Gender Bias.

Alcohol Alcohol 2019 Feb 23. Epub 2019 Feb 23.

Bournemouth University, Faculty of Science and Technology, Talbot Campus, Fern Barrow, Poole, UK.

Aims: This work aimed to assess the performance of hair and fingernail ethyl glucuronide (EtG) measurement for use as a biomarker of alcohol consumption in persons with known drinking history across a range of drinking behaviours.

Methods: EtG concentrations were assessed from the hair and fingernails of 50 study participants. Alcohol consumption of the previous 90 days was assessed by participant interview using the alcohol timeline follow-back method. Read More

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http://dx.doi.org/10.1093/alcalc/agz015DOI Listing
February 2019

Alcohol Craving Predicts Relapse After Residential Addiction Treatment.

Alcohol Alcohol 2019 Mar;54(2):167-172

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Aims: Replicate the previously reported association of elevated alcohol craving, measured by Penn Alcohol Craving Scale (PACS) during residential treatment, with post-treatment relapse and explore whether elevated craving scores 3 months post-treatment are also associated with subsequent relapse.

Methods: Alcohol craving was assessed with the PACS on admission and at several time points post-treatment in 190 subjects with DSM-IV diagnosis of alcohol dependence admitted to residential treatment. Data about relapse to any drinking (primary outcome measure) was collected at 3, 6, 9 and 12 months after treatment. Read More

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http://dx.doi.org/10.1093/alcalc/agy093DOI Listing

Systematic Reviews of Mindfulness and Acceptance and Commitment Therapy for Alcohol Use Disorder: Should we be using Third Wave Therapies?

Alcohol Alcohol 2019 Mar;54(2):159-166

Discipline of Addiction Medicine, National Health and Medical Research Council Centre for Excellence in Mental Health and Substance Use, University of Sydney, NSW, Australia.

Aims: Third wave therapies have shown efficacy for treating emotional disorders and potential for treating substance use disorders. There is developing interest in whether they can more specifically be used for treating alcohol use disorders (AUDs). We were interested in whether third wave therapies have value alongside current evidence-based psychosocial treatments for AUDs. Read More

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http://dx.doi.org/10.1093/alcalc/agy089DOI Listing

Age of Last Alcohol Use Disorder Relates to Processing Speed Among Older Adults Living with HIV.

Alcohol Alcohol 2019 Mar;54(2):139-147

Department of Psychiatry, University of California, San Diego, HIV Neurobehavioral Research Program, San Diego, CA, USA.

Aims: Older persons living with HIV (PLWH) and past alcohol use disorder (AUD) are at higher risk for neurocognitive deficits compared to those with either condition alone; however, factors underlying this relationship are unknown. Given that aging potentiates multi-system damage from alcohol misuse, the current study examined whether neurocognitive functioning among older adults relates to the age at which they last met criteria for AUD (i.e. Read More

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http://dx.doi.org/10.1093/alcalc/agz008DOI Listing

The Impact of Therapists' Responses to Resistance to Change: A Sequential Analysis of Therapist Client Interactions in Motivational Interviewing.

Alcohol Alcohol 2019 Mar;54(2):173-176

Leeds Institute of Health Sciences, University of Leeds, UK.

Aims: The study aims to examine how therapists trained in motivational interviewing (MI) respond to resistance and whether this has an impact on subsequent client speech.

Methods: Fifty recorded Motivational Enhancement Therapy sessions were examined using a sequential behavioural coding method for speech. Client counter-change talk formed the baseline for coding and categorizing subsequent therapist speech and the following client speech. Read More

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http://dx.doi.org/10.1093/alcalc/agz003DOI Listing
March 2019
1 Read

Emotional Face Processing among Treatment-Seeking Individuals with Alcohol Use Disorders: Investigating Sex Differences and Relationships with Interpersonal Functioning.

Alcohol Alcohol 2019 Feb 23. Epub 2019 Feb 23.

Department of Psychiatry, University of Florida, Gainesville, FL, USA.

Background: Individuals in treatment for alcohol use disorder (AUD) display deficits across a broad range of cognitive processes. Disruptions in affective processing are understudied, but may be particularly important for interpersonal functioning and post-treatment adaptation. In particular, the role of sex in AUD-associated emotion processing deficits remains largely unaddressed and was a focus of the current investigation. Read More

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http://dx.doi.org/10.1093/alcalc/agz010DOI Listing
February 2019
3 Reads

Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India.

Alcohol Alcohol 2019 Mar;54(2):148-151

Centre for Addiction Medicine, Department of Psychiatry National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru, India.

Aim: To define the prevalence and clinical presentation of pellagra, a multi-systemic disease caused by the deficiency of niacin, in patients admitted to a tertiary addiction treatment centre in southern India, with alcohol dependence syndrome (ADS)-(ICD10).

Methods: Review of the health records of 2947 patients who received inpatient care for ADS between 2015 and 2017.

Results: Out of 2947, 31 (1%) were diagnosed with pellagra. Read More

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http://dx.doi.org/10.1093/alcalc/agz004DOI Listing
March 2019
10 Reads

How to Interpret Hair EtG Concentrations in Individuals with High Body Mass Index? Brief Commentary on: Influence of Body Mass Index on Hair Ethyl Glucuronide Concentrations.

Alcohol Alcohol 2019 Mar;54(2):188-189

Toxicological Center, Antwerp University, Antwerp, Belgium.

Body mass index (BMI) is a variable that complicates the interpretation of the alcohol metabolite ethyl glucuronide (EtG) in hair. However, direction on how EtG should currently be interpreted within individuals consuming moderate and excessive daily amounts of alcohol related to their BMI is lacking. In light of interpretation of EtG in individuals with high BMI, we present post hoc analysis of earlier data regarding the effect of BMI on hair EtG concentrations. Read More

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http://dx.doi.org/10.1093/alcalc/agz006DOI Listing
March 2019
1 Read

The Methanol Poisoning Outbreaks in Iran 2018.

Alcohol Alcohol 2019 Mar;54(2):128-130

Department of Health in Emergencies and Disasters, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Aims: To present epidemiological data, probable causes and lessons learned from the outbreak of methanol poisoning in Iran in September 2018, and relate this to the increasing incidence of methanol poisoning worldwide over recent decades.

Method: Analysis of all available reliable field information, official news reports and reports from the country's forensic medicine organization and the Ministry of Health.

Results: Overall, 768 people in Iran were documented as poisoned from September 7 to October 7 2018 by consuming an informal alcohol containing methanol, of whom 76 died (10. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/alcalc/agz005DOI Listing
March 2019
6 Reads

Does Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol?

Alcohol Alcohol 2019 Mar;54(2):180-187

Department of Psychiatry, School of Medicine, Yale University, 34 Park Street, New Haven, CT, USA.

Aims: Subjective response to alcohol and impulsivity are both independent predictors of alcohol use and may be related risk factors for alcohol use disorders (AUDs). Recent findings suggest that more impulsive individuals may experience higher risk subjective response patterns at moderate-to-high doses of alcohol. However, whether these relationships are observable early in a drinking occasion remains an open question. Read More

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http://dx.doi.org/10.1093/alcalc/agy092DOI Listing
March 2019
3 Reads

Unhelpful Prescribing in Alcohol Use Disorder: Risk and Averting Risk.

Authors:
Jonathan Chick

Alcohol Alcohol 2019 01;54(1):1-4

Castle Craig Hospital, Scotland, UK

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http://dx.doi.org/10.1093/alcalc/agy090DOI Listing
January 2019
3 Reads

Individual and Social Factors Related to Trajectories of Blackouts among Underage Drinkers in the Emergency Department.

Alcohol Alcohol 2019 Jan 4. Epub 2019 Jan 4.

Addiction Center, University of Michigan Department of Psychiatry, Ann Arbor, MI.

Aims: Alcohol-related blackouts can result in acute injuries and other negative outcomes. Among underage risky drinkers, we examined longitudinal trajectories of blackout frequency following an emergency department (ED) visit, and identified baseline characteristics associated with blackout trajectory membership.

Methods: Participants (ages 14-20; N = 836) attending an ED who screened positive for risky drinking and enrolled in a randomized-controlled trial of brief alcohol interventions were assessed at baseline, 3-, 6-, and 12-months. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/alcalc/agy087DOI Listing
January 2019
11 Reads

3D Analysis of Philtrum Depth in Children with Fetal Alcohol Syndrome.

Alcohol Alcohol 2019 Mar;54(2):152-158

Department of Orthodontics, University of Münster, Albert-Schweitzer-Campus 1, Münster, Germany.

Aims: Diagnosis of fetal alcohol spectrum disorder (FASD) is complex and difficult. The estimated number of unreported FASD is thus assumed to be substantial. In our cross-sectional study, we aimed to identify possible metric differences in philtrum depth in children with fetal alcohol syndrome (FAS) compared to healthy controls based on non-invasive 3D facial scanning in order to provide an objective, metrical tool improving FASD diagnosis. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/alcalc/agy088DOI Listing
March 2019
11 Reads

Executive Functioning Moderates Responses to Appetitive Cues: A Study in Severe Alcohol Use Disorder and Alcoholic Liver Disease.

Alcohol Alcohol 2019 Jan;54(1):38-46

Department of Psychology, NHMRC Centre of Research Excellence in Mental Health and Substance Use, Macquarie University, NSW, Australia.

Aim: To examine subjective and psychophysiological responses to appetitive cues during an alcohol cue reactivity task, and its relation to alcoholic liver disease and assess whether executive functioning is associated with appropriate regulation of cue-elicited responses in individuals with severe alcohol use disorder (AUD).

Methods: Seventeen treatment-seeking alcoholic liver disease patients and a control group of treatment-seeking severe AUD participants completed neuropsychological executive functioning measures (Stroop task; Trail-making test) and the cue reactivity task, whereby control (water) and alcohol beverage cues were presented, followed by respective recovery periods. Subjective alcohol craving and heart rate variability were recorded across the task. Read More

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https://academic.oup.com/alcalc/article/54/1/38/5253747
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http://dx.doi.org/10.1093/alcalc/agy083DOI Listing
January 2019
4 Reads

Healthcare Utilisation, Morbidities and Alcohol Use Monitoring Prior to Alcoholic Psychosis Diagnosis.

Alcohol Alcohol 2019 Mar;54(2):131-138

Division of Primary Care, School of Medicine, University of Nottingham, University Park, Nottingham, UK.

Aims: The aim of this study was to describe healthcare utilisation, morbidities and monitoring of alcohol use in patients prior to a diagnosis of alcoholic psychosis in order to inform the early identification of patients at risk.

Methods: Using linked general practice and hospitalisation data in England (April 1997 to June 2014), we identified 1731 individuals (≥18 years) with a clinical recorded diagnosis of alcoholic psychosis and 17,310 matched controls without the disorder, we examined all prior general practitioner (family doctor) visits, hospitalisations, medically recorded morbidities and alcohol assessment/interventions records. Poisson regression models were used to compare rates of healthcare utilisation in people with alcoholic psychosis to those without. Read More

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http://dx.doi.org/10.1093/alcalc/agy085DOI Listing
March 2019
11 Reads

Higher Creatinine Concentrations in Ethyl Glucuronide-Positive Urine Specimens Collected from Subjects in a Controlled Alcohol Abstinence Program: Is Serum Creatinine a Good Marker of Renal Function in Drinkers?

Alcohol Alcohol 2019 Jan;54(1):19-22

Department of Toxicology & Forensic Toxicology, SYNLAB MVZ Weiden GmbH, Zur Kesselschmiede 4, Weiden, Germany.

Aims: The aim of this study was to examine urine creatinine concentrations in drivers submitted to controlled alcohol abstinence programs.

Methods: Urine samples (n = 32,210) were screened for ethyl glucuronide (EtG) by immunoassay during a 2-year period. Non-negatives underwent EtG and ethyl sulfate (EtS) confirmation by coupled-column Liquid Chromatography-Tandem Mass Spectrometry. Read More

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http://dx.doi.org/10.1093/alcalc/agy084DOI Listing
January 2019
1 Read

Maximum Time Between Tests: A Digital Biomarker to Detect Therapy Compliance and Assess Schedule Quality in Measurement-Based eHealth Systems for Alcohol Use Disorder.

Alcohol Alcohol 2019 Jan;54(1):70-72

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

Aim: To evaluate, in a breathalyzer-based eHealth system, whether the time-based digital biomarker 'maximum time between tests' (MTBT) brings valuable information on alcohol consumption patterns as confirmed by correlation with blood phosphatidyl ethanol (PEth), serum carbohydrate deficient transferrin (CDT) and timeline follow-back data.

Method: Data on 54 patients in follow-up for treatment of alcohol use disorder were analysed.

Results: The model of weekly averages of 24-log transformed MTBT adequately described timeline follow-back data (P  <  0. Read More

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http://dx.doi.org/10.1093/alcalc/agy086DOI Listing
January 2019
4 Reads

A Review of Baclofen Overdoses in Australia: Calls to a Poisons Information Centre and a Case Series.

Alcohol Alcohol 2019 Jan;54(1):73-78

Drug Health Services, Royal Prince Alfred Hospital, NSW, Australia.

Aim: to describe trends in baclofen reports to Australia's largest Poisons Information Centre (PIC) and present a case series detailing severity of overdoses.

Short Summary: PBS data demonstrates baclofen use is increasing in Australia, while calls to NSWPIC illustrate an increase in number of exposures associated with toxicity. Baclofen toxicity may require prolonged intensive care admission. Read More

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http://dx.doi.org/10.1093/alcalc/agy082DOI Listing
January 2019
3 Reads

Inhibition by Ethanol of Shear Stress-Induced Formation of Platelet Thrombi in Whole Blood.

Alcohol Alcohol 2019 Jan;54(1):13-18

Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Aims: The risk of thromboatherosclerotic disease is lower in moderate drinkers than in non-drinkers. We investigated the effects of ethanol on platelet aggregation under a condition with shear stress.

Short Summary: Shear stress-induced formation of platelet thrombi is inhibited by ethanol at its attainable concentrations after drinking. Read More

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http://dx.doi.org/10.1093/alcalc/agy081DOI Listing
January 2019
18 Reads

Effects of Moderate Ethanol Consumption on Lipid Metabolism and Inflammation Through Regulation of Gene Expression in Rats.

Alcohol Alcohol 2019 Jan;54(1):5-12

School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, USA.

Aims: Epidemiological studies and experimental data from rodent models have reported a non-linear relationship between consumption of alcohol and cardiovascular disease (CVD) risk that suggests that light-to-moderate drinking as opposed to excessive consumption may provide some cardiovascular benefits. The present study examined potential mechanisms by which moderate alcohol consumption may provide a protective effect against CVD.

Short Summary: Wistar rats exposed for 3 months to a 20% ethanol intermittent-access voluntary drinking paradigm displayed a reduction in epididymal fat, blood glucose and non-HDL and total cholesterol. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
Publisher Site
http://dx.doi.org/10.1093/alcalc/agy079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324654PMC
January 2019
19 Reads

Executive Dysfunction in Patients With Korsakoff's Syndrome: A Theory-Driven Approach.

Alcohol Alcohol 2019 Jan;54(1):23-29

Donders Institute for Brain, Cognition and Behaviour, Radboud University, Montessorilaan 3, Nijmegen, The Netherlands.

Aims: In addition to amnesia, executive deficits are prominent in Korsakoff's syndrome (KS), yet poorly studied. This study investigates the degree of executive dysfunction in patients with KS for the three main executive subcomponents shifting, updating and inhibition using novel, theory-driven paradigms.

Short Summary: Compared to healthy controls, patients with KS show impairments on the executive subcomponents shifting and updating, but not on inhibition. Read More

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http://dx.doi.org/10.1093/alcalc/agy078DOI Listing
January 2019
14 Reads

Reply to: Effects of a Comprehensive Pro-alcohol Policy in Washington State.

Alcohol Alcohol 2019 Jan;54(1):120-121

Alcohol Research Group, Public Health Institute, 6001 Shellmound Ave, Suite 450, Emeryville, CA, USA.

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
Publisher Site
http://dx.doi.org/10.1093/alcalc/agy077DOI Listing
January 2019
2 Reads

Effects of a Comprehensive Pro-alcohol Policy in Washington State.

Authors:
Alain Braillon

Alcohol Alcohol 2019 Jan;54(1):119-121

Department of Medicine, Alcohol Treatment Unit, University Hospital, Amiens, France.

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http://dx.doi.org/10.1093/alcalc/agy076DOI Listing
January 2019
1 Read
2.889 Impact Factor

Dynamic Features of Problematic Drinking: Alcohol Use Disorder Latent Classes Across Ages 18-64.

Alcohol Alcohol 2019 Jan;54(1):97-103

Department of Biobehavioral Health and the Edna Bennett Pierce Prevention Research Center, The Pennsylvania State University, 314 Biobehavioral Health, University Park, PA, USA.

Aims: Alcohol use disorders (AUDs) are linked with numerous severe detrimental outcomes. Evidence suggests that there is a typology of individuals with an AUD based on the symptoms they report. Scant research has identified how these groups may vary in prevalence by age, which could highlight aspects of problematic drinking behavior that are particularly salient at different ages. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
Publisher Site
http://dx.doi.org/10.1093/alcalc/agy074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324653PMC
January 2019
32 Reads

Patterns in Reduction or Cessation of Drinking in Australia (2001-2013) and Motivation for Change.

Alcohol Alcohol 2019 Jan;54(1):79-86

Centre for Population Health, Burnet Institute, Melbourne, Australia.

Aims: This paper examines: (a) change over time (2001-2013) in recently reducing or ceasing drinking in the Australian population and (b) the reasons given for reducing or ceasing drinking in the most recent survey (2013); stratified by sex and age group.

Short Summary: Rates of reducing and ceasing drinking increased between 2001 and 2013 in Australia. Young people were more likely to modify drinking due to lifestyle and enjoyment reasons; older groups were more likely to report health reasons. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
Publisher Site
http://dx.doi.org/10.1093/alcalc/agy072DOI Listing
January 2019
13 Reads

Stress and Alcohol Priming of Brain Toll-Like Receptor Signaling in Alcohol Use Disorder.

Alcohol Alcohol 2018 Nov;53(6):639-641

Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/alcalc/agy061DOI Listing
November 2018
1 Read

Alcohol and Alcoholism: Then, Now and The Future of 'The Red Journal'.

Alcohol Alcohol 2018 Nov;53(6):637-638

Alcohol and Alcoholism Editorial Office.

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http://dx.doi.org/10.1093/alcalc/agy075DOI Listing
November 2018
1 Read

Malocclusion Can Give Additional Hints for Diagnosis of Fetal Alcohol Spectrum Disorder.

Alcohol Alcohol 2019 Jan;54(1):56-61

Department of Orthodontics, University Münster, Albert-Schweitzer-Campus 1, Münster, Germany.

Aims: Fetal alcohol spectrum disorder (FASD) is a developmental disorder caused by maternal alcohol intake (prevalence: 0.77%). Malocclusion has been described in case reports of patients with FASD, but reliable evidence for associations between FASD and malocclusion is not documented. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
Publisher Site
http://dx.doi.org/10.1093/alcalc/agy071DOI Listing
January 2019
25 Reads

Transitions Through Stages of Alcohol Use, Use Disorder and Remission: Findings from Te Rau Hinengaro, The New Zealand Mental Health Survey.

Alcohol Alcohol 2019 Jan;54(1):87-96

Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, 464 Cumberland St., Dunedin, New Zealand.

Aims: To understand transitions from alcohol use to disorder, we examine timing of transitions between stages of alcohol use and associations between transitions and socio-demographic factors.

Short Summary: Using nationally representative data, we found that the majority of alcohol use disorders develop by age 25. Increased alcohol use within a participant's cohort was associated with subsequent transition across all stages of alcohol use and disorder. Read More

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https://academic.oup.com/alcalc/advance-article/doi/10.1093/
Publisher Site
http://dx.doi.org/10.1093/alcalc/agy069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324656PMC
January 2019
20 Reads