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    1 OF 71

    Population Level Effects of a Mass Media Alcohol and Breast Cancer Campaign: A Cross-Sectional Pre-Intervention and Post-Intervention Evaluation.
    Alcohol Alcohol 2017 Nov 16:1-8. Epub 2017 Nov 16.
    School of Health & Social Care, Teesside University, Middlesbrough, Tees Valley TS1 3BX, UK.
    Aims: To examine the relationship between a TV-led breast cancer mass-media campaign in the North East of England (conducted in two waves: Jul/2015 and Nov/2015), awareness of the link between alcohol and cancer, intention to reduce alcohol consumption and support for alcohol related policies.

    Methods: Three cross-sectional surveys were conducted; one over the 2 weeks pre-campaign (n = 572); one immediately following campaign wave 1 (n = 576); and another immediately following campaign wave 2 (n = 552). Survey questions assessed; campaign exposure; awareness of the links between alcohol and related cancers; intention to change alcohol consumption; and support for alcohol related policies. Read More

    Craving as a DSM-5 Symptom of Alcohol Use Disorder in Non-Treatment Seekers.
    Alcohol Alcohol 2017 Nov 14:1-6. Epub 2017 Nov 14.
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, CA 900951563, USA.
    Aims: DSM-5 has added craving as a new criterion and changed the diagnostic structure of alcohol use disorder (AUD). Though craving has long been a target of intervention, less is known about the impact this addition will have on prevalence and factor structure of AUD, particularly in non-treatment seeker with alcohol problems.

    Methods: Non-treatment seeking individuals reporting alcohol-related problems (N = 296) completed a structured clinical interview and the Penn Alcohol Craving Scale (PACS). Read More

    Prenatal Alcohol Exposure and Suspected Hearing Impairment Among Children: A Population-based Retrospective Cohort Study.
    Alcohol Alcohol 2017 Nov 14:1-7. Epub 2017 Nov 14.
    Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
    Aims: This study aimed to examine the association between prenatal alcohol exposure and hearing impairment among Japanese children using early childhood health check-up data.

    Methods: This retrospective cohort study used population-based health check-up data for children who were born between April 2000 and March 2013 in Hofu city, Japan. Logistic regression models were used to evaluate the association between prenatal alcohol exposure and hearing impairment among children at the age of 36 months. Read More

    Treatment of Alcohol-Induced Psychotic Disorder (Alcoholic Hallucinosis)-A Systematic Review.
    Alcohol Alcohol 2017 Nov 14:1-9. Epub 2017 Nov 14.
    Betsi Cadwaladr University Health Board (BCUHB), Heddfan Unit, Wrexham Maelor Hospital, Wrexham, Wales LL13 7TD, UK.
    Aims: To evaluate the effectiveness of evidence based treatments for alcohol-induced psychotic disorder (AIPD) as described by ICD-10 and DSM-5, a condition that is distinct from schizophrenia and has a close relationship with alcohol withdrawal states.

    Method: Systematic review using PRISMA guidelines.

    Results: Of 6205 abstracts found, fifteen studies and ten case reports met criteria and were examined. Read More

    Ghrelin is Related to Personality Differences in Reward Sensitivity and Impulsivity.
    Alcohol Alcohol 2017 Nov 9:1-5. Epub 2017 Nov 9.
    Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT.
    Aims: Ghrelin, a feeding-related peptide mainly produced in the stomach, has been linked to reward mechanisms for food and drugs of abuse in addition to traits of impulsivity. This study is a secondary analysis of an existing data set designed to examine the direct relationships between fasting ghrelin levels and reward sensitivity/impulsivity in healthy social drinkers.

    Methods: Participants (n = 20) were recruited from an original study examining the subjective effects of alcohol among social drinkers. Read More

    Alcohol Warning Label Awareness and Attention: A Multi-method Study.
    Alcohol Alcohol 2017 Nov 9:1-7. Epub 2017 Nov 9.
    School of Management, Xiamen University, 422 Siming S Rd, Siming Qu, Xiamen Shi, Fujian Sheng, 361005, China.
    Aims: Evaluation of alcohol warning labels requires careful consideration ensuring that research captures more than awareness given that labels may not be prominent enough to attract attention. This study investigates attention of current in market alcohol warning labels and examines whether attention can be enhanced through theoretically informed design. Attention scores obtained through self-report methods are compared to objective measures (eye-tracking). Read More

    Perfect for a Gin and Tonic: How Context Drives Consumption Within a Modified Bogus Taste Test.
    Alcohol Alcohol 2017 Nov 9:1-7. Epub 2017 Nov 9.
    Department of Psychology, Edge Hill University, St Helens Rd, Ormskirk L39 4QP, UK.
    Aim: To implement a modified bogus taste test (BTT) and to examine the interactive effects of environmental and social contexts on levels of 'alcohol' consumption.

    Method: University students (Study 1 n = 38, Study 2 n = 80), recruited via opportunity sampling, completed a modified BTT under the pretence of assessing garnish preference for gin and tonic. All participants were tested alone or as part of an existing friendship group. Read More

    Nutritional Status During Inpatient Alcohol Detoxification.
    Alcohol Alcohol 2017 Nov 9:1-7. Epub 2017 Nov 9.
    Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, AP-HP, 200 rue du Faubourg Saint Denis, 75475 Paris Cedex 10, France.
    Aims: As low rates of thiamine are thought to be implicated in alcohol-related cognitive disorders, we wanted to assess patients with alcohol use disorders (AUD) during detoxification for their nutritional status and test if vitamins blood levels were associated with a surrogate of cognitive impairment.

    Methods: We performed a retrospective chart review of medical records of 94 consecutive patients hospitalized for alcohol detoxification in a specialized addiction medicine department. Nutritional status was assessed with Body Mass Index (BMI). Read More

    Inclusion of Alcoholic Associations Into a Public Treatment Programme for Alcoholism Improves Outcomes During the Treatment and Continuing Care Period: A 6-Year Experience.
    Alcohol Alcohol 2017 Oct 26:1-11. Epub 2017 Oct 26.
    Addictive Disorders Network (Carlos III Health Institute, RETICS PROGRAMME), Spain.
    Aims: To investigate whether inclusion of self-help groups into the hospital treatment programme improves the prognosis of alcohol dependence through the treatment period; and to examine therapeutic adherence and prognosis during continuing care.

    Method: Patients attending the treatment programme at the 'Hospital 12 de Octubre' were randomized into two groups. In Group A (n = 123), patients received the usual treatment included in our programme, whereas in Group B (n = 126), patients also attended self-help groups. Read More

    Maintenance of Abstinence in Self-Help Groups.
    Alcohol Alcohol 2017 Oct 26:1-6. Epub 2017 Oct 26.
    Department of Addictology, CHRU Caremeau, Nîmes, France.
    Aim: To analyse abstinence rates 12 months after alcohol cessation in a sample of French subjects participating in support group meetings.

    Method: The project was co-designed with support group representatives, and co-investigator roles were delegated to meeting managers. Subjects who had stopped drinking for <3 months were included. Read More

    Evaluation of Alcohol Screening and Community-Based Brief Interventions in Rural Western Kenya: A Quasi-Experimental Study.
    Alcohol Alcohol 2017 Oct 26:1-8. Epub 2017 Oct 26.
    College of Public Health Sciences, Chulalongkorn University, Soi Chulalongkorn 62, Phyathai Rd., Bangkok 10330, Thailand.
    Aims: To assess the effectiveness of community-based alcohol brief interventions (ABI) implemented by community-health workers with and without motivational talks (MT) by former drinkers, in reducing harmful and hazardous alcohol consumption.

    Methods: We conducted a three-arm quasi-experimental study (one control and two intervention groups) between May and December 2015 in Kakamega County, Kenya. Participants were hazardous or harmful alcohol drinkers with an Alcohol Use Disorders Identification Test (AUDIT) score of 8-19 at baseline. Read More

    The effect of increased alcohol availability on alcohol-related health problems up to the age of 42 among children exposed in utero: a natural experiment.
    Alcohol Alcohol 2017 Oct 19:1-8. Epub 2017 Oct 19.
    Department of Health Sciences, Faculty of Medicine, Lund University, Box 157, 221 00 Lund, Sweden.
    Aim: To examine whether exposure to increased alcohol availability in utero is associated with later alcohol-related health problems.

    Method: Register-linked population-based longitudinal study using data from a natural experiment setting, including 363 286 children born 1965-71. An experimental alcohol policy change was piloted in two regions of Sweden in 1967-68, where access to strong beer increased for 16-20 year old. Read More

    Environmental Context Influences Visual Attention to Responsible Drinking Messages.
    Alcohol Alcohol 2017 Oct 13:1-6. Epub 2017 Oct 13.
    School of Applied Sciences, Division of Psychology, London South Bank University, 103 Borough Road, London SE1 0AA, UK.
    Aims: Responsible drinking messages (RDMs) are used as a key tool to reduce alcohol-related harms. A common form of RDM is in a poster format displayed in places such as bars, bus stops and toilet cubicles. However, evidence for the effectiveness of RDMs remains limited. Read More

    Sociodemographic Differences Between Alcohol Use and Sickness Absence: Pooled Analysis of Four Cohort Studies.
    Alcohol Alcohol 2017 Oct 13:1-9. Epub 2017 Oct 13.
    Finnish Institute of Occupational Health, PB 40, 00032 TYÖTERVEYSLAITOS, Helsinki, Finland.
    Aims: We examined differences in sickness absence in relation to at-risk drinking and abstinence, taking into account potential changes in consumption.

    Methods: We used individual-participant data (n = 46,514) from four prospective cohort studies from Finland, France and the UK. Participants responded to a survey on alcohol use at two time points 4-6 years apart, and were linked to records of sickness absence for an ~6-year follow-up after the latter survey. Read More

    Oxytocin Genotype Moderates the Impact of Social Support on Psychiatric Distress in Alcohol-Dependent Patients.
    Alcohol Alcohol 2017 Oct 13:1-7. Epub 2017 Oct 13.
    University of Michigan Addiction Research Center, Ann Arbor, MI, USA.
    Aims: The social environment strongly influences individual mental health. Individuals with strong social support systems tend to experience higher levels of well-being, lower levels of psychological distress and exhibit fewer psychiatric symptoms. However, there is a significant degree of individual variability as to the extent to which social support is beneficial to overall mental health. Read More

    More Alcohol, More Liver Injury: Not Always True.
    Alcohol Alcohol 2017 Nov;52(6):627-628
    Departments of Medicine, Pharmacology & Toxicology, 505S Hancock Street, CTR503, Louisville, KY 40202-1617, USA.
    An animal model of alcoholic liver disease (ALD) that recapitulates human disease is an unmet need. An alcohol-preferring strain and WT mice were fed alcohol by different techniques and with different diet compositions. Interestingly, the greatest alcohol consumers did not develop the worst ALD. Read More

    Use of a crossed high alcohol preferring (cHAP) mouse model with the NIAAA-model of chronic-binge ethanol intake to study liver injury.
    Alcohol Alcohol 2017 Nov;52(6):629-637
    Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, USA.
    Aims: This study sought to compare mice bred to preferentially consume high amounts of alcohol (crossed-high alcohol preferring, cHAP) to c57BL/6 (C57) mice using a chronic-binge ethanol ingestion model to induce alcoholic liver disease (ALD).

    Methods: Male C57 and cHAP mice were randomized to a Lieber-DeCarli control (LDC) diet, Lieber-DeCarli 5% (v/v) ethanol (LDE) diet or free-choice between 10% (v/v) ethanol in drinking water (EtOH-DW) and DW. After 4 weeks mice were gavaged with either 9 g/kg maltose-dextrin (LDC+MD) or 5 g/kg EtOH (LDE+Binge, EtOH-DW+Binge). Read More

    Baclofen Self-Poisoning in the Era of Changing Indication: Multicentric Reports to a French Poison Control Centre.
    Alcohol Alcohol 2017 Nov;52(6):665-670
    Poison Control Center, Angers University Hospital, Angers, 4 rue Larrey, 49 933 Angers Cedex 9,France.
    Aims: Baclofen has gained interest in treating alcohol use disorder patients. These patients are at risk of voluntary drug intoxications. Understanding the context of baclofen's widespread use for alcohol use disorder, a recent evaluation of the epidemiology, morbidity and mortality of baclofen self-poisoning episodes is necessary. Read More

    The Science of Absent Evidence: Is There Such Thing as an Effective Responsible Drinking Message?
    Alcohol Alcohol 2017 Sep 20:1-5. Epub 2017 Sep 20.
    School of Applied Sciences, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.
    Aims: To review the effectiveness of responsible drinking messages (RDMs).

    Methods: We searched PsycINFO, MEDLINE and Google Scholar to June 2016 for studies evaluating the effectiveness of RDMs. Only eight studies met the inclusion/exclusion criteria. Read More

    Prevalence of Polysubstance Abuse and Dual Diagnosis in Patients Admitted to Alcohol Rehabilitation Units for Alcohol-Related Problems in Italy: Changes in 15 Years.
    Alcohol Alcohol 2017 Nov;52(6):699-705
    U.O. Riabilitazione Alcologica, Istituti Clinici Scientifici Maugeri, IRCCS, Via S. Maugeri, 10, 27100, Pavia (Pavia), Italy.
    Aims: Alcohol abuse has long been known as a disease with social and economic burden to society. Given the complex nature of alcohol treatment, it is worthwhile to examine the change over time of patients admitted to residential alcohol abuse rehabilitation units.

    Methods: The data were collected from two Italian projects on alcoholics performed in the mid-1990s (ASSALT) and in 2009 (CORRAL), respectively. Read More

    Effectiveness and Cost-effectiveness of Opportunistic Screening and Stepped-care Interventions for Older Alcohol Users in Primary Care.
    Alcohol Alcohol 2017 Nov;52(6):655-664
    Department of Health Sciences, University of York, York YO10 5DD, UK.
    Aims: To compare the clinical effectiveness and cost-effectiveness of a stepped-care intervention versus a minimal intervention for the treatment of older hazardous alcohol users in primary care.

    Method: Multi-centre, pragmatic RCT, set in Primary Care in UK. Patients aged ≥ 55 years scoring ≥ 8 on the Alcohol Use Disorders Identification Test were allocated either to 5-min of brief advice or to 'Stepped Care': an initial 20-min of behavioural change counselling, with Step 2 being three sessions of Motivational Enhancement Therapy and Step 3 referral to local alcohol services (progression between each Step being determined by outcomes 1 month after each Step). Read More

    Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Alcohol Consumption are Associated With Asymptomatic Cardiac Remodeling and Subclinical Systolic Dysfunction in Large Community-Dwelling Asians.
    Alcohol Alcohol 2017 Nov;52(6):638-646
    Department of Medicine, MacKay Medical College, No. 46, Sec. 3, Zhongzheng Rd. New Taipei City Sanzhi Dist. 252, New Taipei City 25245, Taiwan.
    Aims: Excessive consumption of alcoholic beverages is associated with cardiac remodeling and cardiomyopathy. We examined the possible association of alcohol use, common Asian genetic variants in genes involved in alcohol metabolism, and cardiac structures/functions alterations.

    Methods: A prospective, community-dwelling survey among individuals with available complete echocardiography examined the associations of alcohol use, cardiac structure/functions, and three common alcohol metabolizing genetic variants, including aldehyde dehydrogenase 2 (ALDH2), alcohol dehydrogenase 1B (ADH1B) and cytochrome P450 (CYP) isoform 2E1 (CYP2E1). Read More

    Is Drinking Contagious? An Analysis of the Collectivity of Drinking Behavior Theory Within a Multilevel Framework.
    Alcohol Alcohol 2017 Nov;52(6):692-698
    University of Hildesheim, Universitätsplatz 1, 31141 Hildesheim, Germany.
    Aims: To analyze the effect of behavioral contagion regarding problematic adolescent alcohol use among countries with varying prevalence of problematic drinking.

    Methods: Nested data from 48,215 12 to 16-year olds from seventh to ninth grade of 25 European countries (48.5% male, M = 13. Read More

    No Impact of Calorie or Unit Information on Ad Libitum Alcohol Consumption.
    Alcohol Alcohol 2017 Sep 18:1-8. Epub 2017 Sep 18.
    UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK.
    Aims: To investigate the impact of unit and calorie information on drinking behaviour in an ad libitum taste test paradigm.

    Methods: In this experimental human laboratory study, participants were randomized to one of four conditions, balanced by gender, using a 2 (unit information: present vs. absent) × 2 (calorie information: present vs. Read More

    Predicting Regulatory Compliance in Beer Advertising on Facebook.
    Alcohol Alcohol 2017 Nov;52(6):730-736
    Department of Community Medicine and Health Care, University of Connecticut School of Medicine, 263 Farmington Ave., MC 6325, Farmington, CTUSA.
    Aims: The prevalence of alcohol advertising has been growing on social media platforms. The purpose of this study was to evaluate alcohol advertising on Facebook for regulatory compliance and thematic content.

    Methods: A total of 50 Budweiser and Bud Light ads posted on Facebook within 1 month of the 2015 NFL Super Bowl were evaluated for compliance with a self-regulated alcohol advertising code and for thematic content. Read More

    You Wouldn't Sober, You Shouldn't Drunk: A Behavioural Change Approach to Changing Attitudes and Responses to Unwanted Sexual Attention in Pubs and Clubs.
    Alcohol Alcohol 2017 Nov;52(6):737-745
    Business School, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK.
    Aims: The objective was to evaluate a campaign designed to influence social norms and re-establish boundaries around the issue of unwanted sexual attention in pubs and clubs. In particular, the campaign aimed to raise awareness, and reduce the acceptability, of unwanted sexual attention when drunk.

    Methods: A before-after-with-control group study design was used to evaluate campaign effectiveness. Read More

    Population Alcohol Consumption as a Predictor of Alcohol-Specific Deaths: A Time-Series Analysis of Aggregate Data.
    Alcohol Alcohol 2017 Nov;52(6):685-691
    Department of Public Health, University of Helsinki, Ilmattarentie 7A, 00610 Helsinki, Finland.
    Aims: The study examines whether the number of alcohol-specific deaths can be predicted by population total and/or beverage-specific alcohol consumption and if, how precisely. The data are annual series of spirits, wine, beer and total consumption and alcohol-specific deaths in Finland in the years 1969-2015.

    Methods: We specify a Auto Regressive Distributed Lags model with cointegrated variables, to be used in prediction. Read More

    "We Have a Right to Know": Exploring Consumer Opinions on Content, Design and Acceptability of Enhanced Alcohol Labels.
    Alcohol Alcohol 2017 Sep 18:1-6. Epub 2017 Sep 18.
    Health Promotion, Chronic Disease and Injury Prevention, Public Health Ontario, 480 University Ave, Suite 300, Toronto, Ontario, Canada M5G 1V2.
    Aims: This study aimed to refine content and design of an enhanced alcohol label to provide information that best supports informed drinking and to gauge consumer acceptability of enhanced alcohol labels among a subset of consumers.

    Methods: Five focus groups (n = 45) were conducted with stakeholders and the general public (age 19+) across one jurisdiction in northern Canada. Interviews were transcribed and analyzed using NVivo software. Read More

    Heavy Drinkers and the Potential Impact of Minimum Unit Pricing-No Single or Simple Effect?
    Alcohol Alcohol 2017 Nov;52(6):722-729
    School of Health and Social Care, Edinburgh Napier University, Edinburgh, EH11 4BN, Scotland, UK.
    Aims: To explore the potential impact of a minimum unit price (MUP: 50 pence per UK unit) on the alcohol consumption of ill Scottish heavy drinkers.

    Methods: Participants were 639 patients attending alcohol treatment services or admitted to hospital with an alcohol-related condition. From their reported expenditure on alcohol in their index week, and assuming this remained unchanged, we estimated the impact of a MUP (50 ppu) on future consumption. Read More

    Forty Years of State Alcohol and Pregnancy Policies in the USA: Best Practices for Public Health or Efforts to Restrict Women's Reproductive Rights?
    Alcohol Alcohol 2017 Nov;52(6):715-721
    San Jose State University School of Social Work, One Washington Square, San Jose, CA 95192-0124, USA.
    Aims: Alcohol consumption during pregnancy remains a public health problem despite >40 years of attention. Little is known about how state policies have evolved and whether policies represent public health goals or efforts to restrict women's reproductive rights.

    Methods: Our data set includes US state policies from 1970 through 2013 obtained through original legal research and from the National Institute for Alcohol Abuse and Alcoholism's (NIAAA)'s Alcohol Policy Information System. Read More

    Personalized Digital Interventions Showed no Impact on Risky Drinking in Young Adults: A Pilot Randomized Controlled Trial.
    Alcohol Alcohol 2017 Nov;52(6):671-676
    Department of Psychology, Social Work and Public Health, Oxford Brookes University, Oxford OX3 0BP, UK.
    Aim: To assess the effectiveness of two personalized digital interventions (OneTooMany and Drinks Meter) compared to controls.

    Method: Randomized controlled trial (AEARCTR-0,001,082). Volunteers for the study, aged 18-30, were randomly allocated to one of two interventions or one of two control groups and were followed up 4 weeks later. Read More

    Preliminary Evidence for Disrupted Nucleus Accumbens Reactivity and Connectivity to Reward in Binge Drinkers.
    Alcohol Alcohol 2017 Nov;52(6):647-654
    Department of Psychiatry, University of Illinois at Chicago, 1747 W Roosevelt Rd Chicago, IL 60608, USA.
    Aims: Dysfunctional brain reward circuitry, particularly in the nucleus accumbens (NAcc), has been proposed as a risk factor for alcohol use disorder (AUD). This risk factor may be evident in binge drinkers (BD), who are at high risk for developing AUD. We examined whole-brain and NAcc reactivity to reward in BD compared to non-binge drinkers (NBD), hypothesizing that groups would differ in their neural reactivity and connectivity. Read More

    Testing the Efficacy of Alcohol Labels with Standard Drink Information and National Drinking Guidelines on Consumers' Ability to Estimate Alcohol Consumption.
    Alcohol Alcohol 2017 Aug 9:1-9. Epub 2017 Aug 9.
    School of Public Health and Health Systems, University of Waterloo, 200 University Ave W, Waterloo, ON, Canada N2L 3G1.
    Aims: Despite the introduction of national drinking guidelines in Canada, there is limited public knowledge of them and low understanding of 'standard drinks (SDs)' which limits the likelihood of guidelines affecting drinking behaviour. This study tests the efficacy of alcohol labels with SD information and Canada's Low-Risk Drinking Guidelines (LRDGs) as compared to %ABV labels on consumers' ability to estimate alcohol intake. It also examines the label size and format that best supports adults' ability to make informed drinking choices. Read More

    A Commentary on the Limits of Alcoholic Beverage Policies.
    Alcohol Alcohol 2017 Nov;52(6):706-714
    Silver School of Social Work, New York University, NY 10003-6654, USA.
    Providing one set of policy measures for all countries as if they were a single, homogeneous entity does not appear to be evidence-based, according to recent research on the effectiveness of alcoholic beverage control policies. Contextual and cultural determinants-social, economic, demographic, cultural and political-appear to be major factors of influencing change in drinking trends, drinking patterns and drinking-related harms. The variable interplay between contextual determinants and alcohol control policy measures implies diverse impacts on consumption and harm according to time, and to the different countries and groups of countries. Read More

    Modifying Alcohol Consumption to Reduce Obesity: A Randomized Controlled Feasibility Study of a Complex Community-based Intervention for Men.
    Alcohol Alcohol 2017 Nov;52(6):677-684
    Dundee City Council, Community Health Inequalities Manager, Mitchell Street Centre, Dundee, UK.
    Objectives: Being obese and drinking more than 14 units of alcohol per week places men at very high risk of developing liver disease. This study assessed the feasibility of a trial to reduce alcohol consumption. It tested the recruitment strategy, engagement with the intervention, retention and study acceptability. Read More

    Melatonin Restores White Blood Cell Count, Diminishes Glycated Haemoglobin Level and Prevents Liver, Kidney and Muscle Oxidative Stress in Mice Exposed to Acute Ethanol Intoxication.
    Alcohol Alcohol 2017 Sep;52(5):521-528
    Institute of Human Physiology, Medical University of Gdansk, Tuwima St. 15, 80-210 Gdansk, Poland.
    Aims: The aim of the study was to examine the effects of melatonin impact on changes in haematological profile, biomarkers of oxidative stress (dienes conjugates, malondialdehyde (MDA), oxidatively modified protein levels, total antioxidant capacity and antioxidant enzyme activity) in liver, muscle, kidney and erythrocytes, and glycated haemoglobin (HBA1c) in mice during acute ethanol stress.

    Methods: Assays were carried out in quadruplicate: control, melatonin (10 mg/kg, 10 days), acute ethanol stress (0.75 g/kg/day, 10 days) and acute ethanol stress plus melatonin groups. Read More

    Rapidly Increasing Trend of Recorded Alcohol Consumption Since the End of the Armed Conflict in Sri Lanka.
    Alcohol Alcohol 2017 Sep;52(5):550-556
    UK Centre for Tobacco and Alcohol Studies, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, NottinghamNG5 1PB, UK.
    Aim: To evaluate temporal changes in recorded alcohol consumption in Sri Lanka during and after the armed conflict 1998-2013.

    Methods: District level alcohol sales, and mid-year population data for the whole study period (1998-2013) were consistently available from the Department of Excise and the Department of Census and Statistics for 18 of 25 districts. These data were used to estimate the recorded per capita consumption for the areas that were not directly exposed to the armed conflict. Read More

    Changes in Pro-Inflammatory Markers in Detoxifying Chronic Alcohol Abusers, Divided by Lesch Typology, Reflect Cognitive Dysfunction.
    Alcohol Alcohol 2017 Sep;52(5):529-534
    Biologie du Comportement, Universite de Louvain-la-Neuve, Louvain-la-Neuve, Belgium.
    Aim: To investigate pro-inflammatory markers in the blood and associate with cognitive impairment.

    Methods: Il-6 and ferritin were assayed in the blood of 27 patients, divided according to Lesch typology, at the commencement and after 21 days of detoxification, together with a battery of cognitive tests.

    Results: A significantly higher mean level of IL-6 was present in the blood of patients with Lesch typology 1 compared to the other typologies 2 and 3 on admission to the Detoxification Ward which did not alter significantly after detoxification. Read More

    Genetic Variants in the Manganese Superoxide Dismutase 2 Gene and in the Catalase Gene are not Associated With Alcoholic Chronic Pancreatitis.
    Alcohol Alcohol 2017 Sep;52(5):535-541
    Department of Medicine II, University Medical Centre Mannheim, Medical Faculty of the University of Heidelberg, Mannheim, Germany.
    Aims: Oxidative stress may contribute to the development of chronic pancreatitis (CP). The enzymes manganese superoxide dismutase 2 (MnSOD, SOD2) and catalase (CAT) counteract free radical activity within the mitochondria and the cytosol. Moreover, CAT activity contributes to the transformation of ethanol to acetaldehyde, a toxic intermediate product of ethanol metabolism, which has been associated with pancreatic damage. Read More

    Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics.
    Alcohol Alcohol 2017 Sep;52(5):542-549
    Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Ctra. Ofra S/N La Cuesta 38320, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Canary Islands, Spain.
    Aims: Alcoholism may be a cardiovascular risk factor. Osteocyte derived molecules such as fibroblast growth factor 23 (FGF-23) and soluble α Klotho have recently been associated with cardiovascular disease, but their role in alcoholics is unknown. We here analyze the behavior of FGF23 and α Klotho in alcoholics. Read More

    Trajectories of Alcohol Use Disorders and Their Differential Impact: A Population-Based Cohort Study in Goa, India.
    Alcohol Alcohol 2017 Sep;52(5):557-563
    Sangath, H No 451 (168), Bhatkar Waddo, Socorro, Porvorim, Bardez 403501, Goa, India.
    Aims: The aim of this study was to examine trajectories of Alcohol Use Disorders (AUD) over a 6 year period and compare the bio-psycho-social correlates between these trajectories.

    Methods: Community-based cohort of 1899 adult men were interviewed in 2006-2008 and 2012-2014. AUD were assessed using the Alcohol Use Disorder Identification Test, and potential correlates including psycho-social problems, morbidity and physiological parameters were measured at follow-up. Read More

    Differential Effects of Alcohol on Memory Performance in Adolescent Men and Women with a Binge Drinking History.
    Alcohol Alcohol 2017 Sep;52(5):610-616
    Department of Psychobiology, University of Valencia, Blasco Ibáñez, 21, 46010 Valencia, Spain.
    Aims: Binge drinking (BD) is characterized by intermittent consumption of large quantities of alcohol in short periods. This pattern of drinking is prevalent among adolescents, and has been associated with undermined learning and memory ability. This study investigates the relationships between a history of BD and the effects of acute exposure to alcohol on learning and memory performance in adolescent men and women. Read More

    Development, Initial Testing and Challenges of an Ecologically Valid Reward Prediction Error FMRI Task for Alcoholism.
    Alcohol Alcohol 2017 Sep;52(5):617-624
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 37-356 Semel Institute, Box 951759, Los Angeles, CA 90095-1759, USA.
    Aims: To advance translational studies of the role of reward prediction error (PE) in alcohol use disorder, the present study sought to develop and conduct an initial test of an alcohol-specific PE task paradigm using functional magnetic resonance imaging in humans.

    Methods: Alcohol dependent or social drinkers received small tastes of their preferred alcohol beverage or control beverage, with preceding visual cues indicating whether alcohol (or water) would be delivered. To assess both positive and negative PE signals, expectancies were systematically violated in both positive (i. Read More

    Systematic Review of Guidelines on Managing Patients with Harmful Use of Alcohol in Primary Healthcare Settings.
    Alcohol Alcohol 2017 Sep;52(5):595-609
    Division of Family Medicine and Primary Health Care, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
    Aim: To appraise existing alcohol guidelines for identifying and managing harmful alcohol use in primary healthcare settings.

    Methods: Seven databases and 18 health organization or medical society websites were systematically searched from inception to 31 October 2016. Guidelines in English language, developed by a national or international medical specialty society, government or health organization, and containing recommendations for identifying and managing harmful use of alcohol in primary healthcare settings, were included. Read More

    Ethyl Glucuronide Elimination Kinetics in Fingernails and Comparison to Levels in Hair.
    Alcohol Alcohol 2017 Sep;52(5):580-586
    Department of Forensic Sciences, Oslo University Hospital, Pb 4950 Nydalen, 0424 Oslo, Norway.
    Aims: Measurement of ethyl glucuronide (EtG) in nail, as a biomarker for alcohol intake, has recently been suggested as alternative to measurement in hair. The aim of this study was to compare levels of EtG in nail and hair, and to investigate the elimination kinetics of EtG in fingernails during an alcohol abstinent period.

    Methods: Overall, 40 subjects (median estimated daily intake of ethanol (EDI) 92. Read More

    Non-Linear Formation of EtG and FAEEs after Controlled Administration of Low to Moderate Doses of Ethanol.
    Alcohol Alcohol 2017 Sep;52(5):587-594
    Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain.
    Aims: Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The aim was to describe the time courses of both biomarkers after ingestion of acute low-moderate doses of ethanol.

    Methods: The study design was double-blind, randomized, crossover and controlled with placebo. Read More

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