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    3512 results match your criteria Alcohol and Alcoholism [Journal]

    1 OF 71

    Melatonin Restores White Blood Cell Count, Diminishes Glycated Haemoglobin Level and Prevents Liver, Kidney and Muscle Oxidative Stress in Mice Exposed to Acute Ethanol Intoxication.
    Alcohol Alcohol 2017 Sep;52(5):521-528
    Institute of Human Physiology, Medical University of Gdansk, Tuwima St. 15, 80-210 Gdansk, Poland.
    Aims: The aim of the study was to examine the effects of melatonin impact on changes in haematological profile, biomarkers of oxidative stress (dienes conjugates, malondialdehyde (MDA), oxidatively modified protein levels, total antioxidant capacity and antioxidant enzyme activity) in liver, muscle, kidney and erythrocytes, and glycated haemoglobin (HBA1c) in mice during acute ethanol stress.

    Methods: Assays were carried out in quadruplicate: control, melatonin (10 mg/kg, 10 days), acute ethanol stress (0.75 g/kg/day, 10 days) and acute ethanol stress plus melatonin groups. Read More

    Rapidly Increasing Trend of Recorded Alcohol Consumption Since the End of the Armed Conflict in Sri Lanka.
    Alcohol Alcohol 2017 Sep;52(5):550-556
    UK Centre for Tobacco and Alcohol Studies, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, NottinghamNG5 1PB, UK.
    Aim: To evaluate temporal changes in recorded alcohol consumption in Sri Lanka during and after the armed conflict 1998-2013.

    Methods: District level alcohol sales, and mid-year population data for the whole study period (1998-2013) were consistently available from the Department of Excise and the Department of Census and Statistics for 18 of 25 districts. These data were used to estimate the recorded per capita consumption for the areas that were not directly exposed to the armed conflict. Read More

    Changes in Pro-Inflammatory Markers in Detoxifying Chronic Alcohol Abusers, Divided by Lesch Typology, Reflect Cognitive Dysfunction.
    Alcohol Alcohol 2017 Sep;52(5):529-534
    Biologie du Comportement, Universite de Louvain-la-Neuve, Louvain-la-Neuve, Belgium.
    Aim: To investigate pro-inflammatory markers in the blood and associate with cognitive impairment.

    Methods: Il-6 and ferritin were assayed in the blood of 27 patients, divided according to Lesch typology, at the commencement and after 21 days of detoxification, together with a battery of cognitive tests.

    Results: A significantly higher mean level of IL-6 was present in the blood of patients with Lesch typology 1 compared to the other typologies 2 and 3 on admission to the Detoxification Ward which did not alter significantly after detoxification. Read More

    Genetic Variants in the Manganese Superoxide Dismutase 2 Gene and in the Catalase Gene are not Associated With Alcoholic Chronic Pancreatitis.
    Alcohol Alcohol 2017 Sep;52(5):535-541
    Department of Medicine II, University Medical Centre Mannheim, Medical Faculty of the University of Heidelberg, Mannheim, Germany.
    Aims: Oxidative stress may contribute to the development of chronic pancreatitis (CP). The enzymes manganese superoxide dismutase 2 (MnSOD, SOD2) and catalase (CAT) counteract free radical activity within the mitochondria and the cytosol. Moreover, CAT activity contributes to the transformation of ethanol to acetaldehyde, a toxic intermediate product of ethanol metabolism, which has been associated with pancreatic damage. Read More

    Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics.
    Alcohol Alcohol 2017 Sep;52(5):542-549
    Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Ctra. Ofra S/N La Cuesta 38320, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Canary Islands, Spain.
    Aims: Alcoholism may be a cardiovascular risk factor. Osteocyte derived molecules such as fibroblast growth factor 23 (FGF-23) and soluble α Klotho have recently been associated with cardiovascular disease, but their role in alcoholics is unknown. We here analyze the behavior of FGF23 and α Klotho in alcoholics. Read More

    Trajectories of Alcohol Use Disorders and Their Differential Impact: A Population-Based Cohort Study in Goa, India.
    Alcohol Alcohol 2017 Sep;52(5):557-563
    Sangath, H No 451 (168), Bhatkar Waddo, Socorro, Porvorim, Bardez 403501, Goa, India.
    Aims: The aim of this study was to examine trajectories of Alcohol Use Disorders (AUD) over a 6 year period and compare the bio-psycho-social correlates between these trajectories.

    Methods: Community-based cohort of 1899 adult men were interviewed in 2006-2008 and 2012-2014. AUD were assessed using the Alcohol Use Disorder Identification Test, and potential correlates including psycho-social problems, morbidity and physiological parameters were measured at follow-up. Read More

    Differential Effects of Alcohol on Memory Performance in Adolescent Men and Women with a Binge Drinking History.
    Alcohol Alcohol 2017 Sep;52(5):610-616
    Department of Psychobiology, University of Valencia, Blasco Ibáñez, 21, 46010 Valencia, Spain.
    Aims: Binge drinking (BD) is characterized by intermittent consumption of large quantities of alcohol in short periods. This pattern of drinking is prevalent among adolescents, and has been associated with undermined learning and memory ability. This study investigates the relationships between a history of BD and the effects of acute exposure to alcohol on learning and memory performance in adolescent men and women. Read More

    Development, Initial Testing and Challenges of an Ecologically Valid Reward Prediction Error FMRI Task for Alcoholism.
    Alcohol Alcohol 2017 Sep;52(5):617-624
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 37-356 Semel Institute, Box 951759, Los Angeles, CA 90095-1759, USA.
    Aims: To advance translational studies of the role of reward prediction error (PE) in alcohol use disorder, the present study sought to develop and conduct an initial test of an alcohol-specific PE task paradigm using functional magnetic resonance imaging in humans.

    Methods: Alcohol dependent or social drinkers received small tastes of their preferred alcohol beverage or control beverage, with preceding visual cues indicating whether alcohol (or water) would be delivered. To assess both positive and negative PE signals, expectancies were systematically violated in both positive (i. Read More

    Systematic Review of Guidelines on Managing Patients with Harmful Use of Alcohol in Primary Healthcare Settings.
    Alcohol Alcohol 2017 Sep;52(5):595-609
    Division of Family Medicine and Primary Health Care, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
    Aim: To appraise existing alcohol guidelines for identifying and managing harmful alcohol use in primary healthcare settings.

    Methods: Seven databases and 18 health organization or medical society websites were systematically searched from inception to 31 October 2016. Guidelines in English language, developed by a national or international medical specialty society, government or health organization, and containing recommendations for identifying and managing harmful use of alcohol in primary healthcare settings, were included. Read More

    Ethyl Glucuronide Elimination Kinetics in Fingernails and Comparison to Levels in Hair.
    Alcohol Alcohol 2017 Sep;52(5):580-586
    Department of Forensic Sciences, Oslo University Hospital, Pb 4950 Nydalen, 0424 Oslo, Norway.
    Aims: Measurement of ethyl glucuronide (EtG) in nail, as a biomarker for alcohol intake, has recently been suggested as alternative to measurement in hair. The aim of this study was to compare levels of EtG in nail and hair, and to investigate the elimination kinetics of EtG in fingernails during an alcohol abstinent period.

    Methods: Overall, 40 subjects (median estimated daily intake of ethanol (EDI) 92. Read More

    Non-Linear Formation of EtG and FAEEs after Controlled Administration of Low to Moderate Doses of Ethanol.
    Alcohol Alcohol 2017 Sep;52(5):587-594
    Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Doctor Aiguader 88, 08003 Barcelona, Spain.
    Aims: Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The aim was to describe the time courses of both biomarkers after ingestion of acute low-moderate doses of ethanol.

    Methods: The study design was double-blind, randomized, crossover and controlled with placebo. Read More

    Barriers to Alcohol Screening Among Hypertensive Patients and the Role of Stigma: Lessons for the Implementation of Screening and Brief Interventions in European Primary Care Settings.
    Alcohol Alcohol 2017 Sep;52(5):572-579
    Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Straße 46, 01187 Dresden, Germany.
    Aims: 1. To quantify barriers to alcohol screening among hypertensive patients reported by primary healthcare professionals. 2. Read More

    A Randomized, Placebo-Controlled Study of High-Dose Baclofen in Alcohol-Dependent Patients-The ALPADIR Study.
    Alcohol Alcohol 2017 Jul;52(4):439-446
    Department of Internal Medicine, Paris Cochin Hospital, Paris Descartes University, France.
    Aims: Alcohol dependence is a major public health issue with a need for new pharmacological treatments. The ALPADIR study assessed the efficacy and safety of baclofen at the target dose of 180 mg/day for the maintenance of abstinence and the reduction in alcohol consumption in alcohol-dependent patients.

    Methods: Three hundred and twenty adult patients (158 baclofen and 162 placebo) were randomized after alcohol detoxification. Read More

    Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study.
    Alcohol Alcohol 2017 Jul;52(4):483-486
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.
    Aims: Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population. Read More

    The Influence of Smoking and Smokeless Tobacco on the Progression, Severity and Treatment Outcome in Alcohol-Dependent Individuals.
    Alcohol Alcohol 2017 Jul;52(4):477-482
    Department of Psychology, University of Gothenburg (KJB, CF), Box 500, SE-40530 Göteborg, Sweden.
    Aims: The influence of tobacco use in alcohol-dependent individuals is not well understood, especially the role of snuffing, which is common in Northern Europe. The aim was therefore to investigate the influence of smoking and snuffing on the progression, severity and treatment outcome in alcohol-dependent individuals. The hypotheses were that concomitant tobacco use (i. Read More

    Gut-liver axis and sterile signals in the development of alcoholic liver disease.
    Alcohol Alcohol 2017 Jul;52(4):414-424
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605, USA.
    Background: Innate immunity plays a critical role in the development of alcohol-induced liver inflammation. Understanding the inter-relationship of signals from within and outside of the liver that trigger liver inflammation is pivotal for development of novel therapeutic targets of alcoholic liver disease (ALD).

    Aim: The aim of this paper is to review recent advances in the field of alcohol-induced liver inflammation. Read More

    The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A 'Ménage à Trois'?
    Alcohol Alcohol 2017 Jul;52(4):403-413
    Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, 10 Center Drive (10CRC/15330), Bethesda, MD 20892-1108, USA.
    Aims: Accumulating evidence for the influence of the gut microbiota on the bidirectional communication along the gut-brain axis suggests a role of the gut microbiota in eating disorders (EDs) and alcohol and substance use disorders. The potential influence of altered gut microbiota (dysbiosis) on behaviors associated with such disorders may have implications for developing therapeutic interventions.

    Methods: A systematic review of preclinical and clinical studies evaluating the gut microbiota, EDs and alcohol and substance use disorders was conducted using MEDLINE, Embase and Web of Science databases with the objective being to examine the role of the gut microbiota in behavioral correlates of these disorders. Read More

    The Leu72Met Polymorphism of the Prepro-ghrelin Gene is Associated With Alcohol Consumption and Subjective Responses to Alcohol: Preliminary Findings.
    Alcohol Alcohol 2017 Jul;52(4):425-430
    Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism (NIAAA) and National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), 10 Center Drive (10CRC/15330), Bethesda, MD 20892, USA.
    Aims: The orexigenic peptide ghrelin may enhance the incentive value of food-, drug- and alcohol-related rewards. Consistent with preclinical findings, human studies indicate a role of ghrelin in alcohol use disorders (AUD). In the present study an a priori hypothesis-driven analysis was conducted to investigate whether a Leu72Met missense polymorphism (rs696217) in the prepro-ghrelin gene (GHRL), is associated with AUD, alcohol consumption and subjective responses to alcohol. Read More

    Ghrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol.
    Alcohol Alcohol 2017 Jul;52(4):431-438
    Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT, USA.
    Aims: Evidence indicates that feeding-related peptides, such as ghrelin, have a role in the rewarding properties of addictive substances like alcohol. Oral alcohol administration significantly suppresses ghrelin. This study was designed to evaluate the effects of two doses of alcohol on ghrelin and examine if ghrelin levels predict the subjective effects of alcohol. Read More

    Age of Onset, Current Use of Alcohol, Tobacco or Marijuana and Current Polysubstance Use Among Male and Female Mexican Students.
    Alcohol Alcohol 2017 Sep;52(5):564-571
    General Medical Services, National Autonomous University of Mexico, Circuito Escolar S-N, Ciudad Universitaria, Delegación Coyoacan, México, D.F.04510, Mexico.
    Aims: This study aimed to examine alcohol, tobacco or marijuana use onset and associations between age of onset and current use, and between age of onset and current polysubstance use among a sample of Mexican young people aged 17-20 years.

    Methods: Alcohol, tobacco, marijuana and other substance use were identified in a 2012 cross-sectional survey of male and female students entering first year university in Mexico City. Chi-square tests and logistic regression models examined associations between gender, age of onset, order of onset, family substance use and current polysubstance use among 22,224 students. Read More

    Preliminary Evaluation of the NIAAA/AAP Brief Alcohol Use Screener.
    Alcohol Alcohol 2017 May;52(3):328-334
    University of Miami, Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, USA.
    Aims: To assess the concurrent validity of the two-item NIAAA/American Academy of Pediatrics Brief Alcohol Use Screener, a developmentally sensitive assessment instrument, in a school-based sample of adolescents.

    Method: The sample consisted of 756 adolescents (53% girls; Mage = 13.7 years; SD = 1. Read More

    Sensation Seeking and Adolescent Alcohol Use: Exploring the Mediating Role of Unstructured Socializing With Peers.
    Alcohol Alcohol 2017 May;52(3):396-401
    Department of Occupational Therapy, Faculty of Social Welfare & Health Sciences, University of Haifa, Israel.
    Background: Researchers have theorized that adolescents high in sensation seeking are particularly sensitive to positive reinforcement and the rewarding outcomes of alcohol use, and thus that the personality vulnerability is a direct causal risk factor for alcohol use. In contrast, the routine activity perspective theorizes that part of the effect of sensation seeking on alcohol use goes through the propensity that sensation seekers have towards unstructured socializing with peers. The study tests a model with indirect and direct paths from sensation seeking and participation in unstructured peer socialization to adolescent alcohol use. Read More

    Price Elasticity of Alcohol Demand in India.
    Alcohol Alcohol 2017 May;52(3):390-395
    Department of Economics and International Business, Sam Houston State University, Huntsville, TX 77341-2118, USA.
    Aims: Using a household survey conducted in 2014, this study estimates price elasticity of demand (PED) for beer, country liquor and spirits in India.

    Methods: Ordinary least-square models were used to estimate the responsiveness in alcohol demand due to price change. A large number of control variables were included to adjust for potential confounding in the model. Read More

    Acute Pancreatitis: Impact of Alcohol Consumption and Seasonal Factors.
    Alcohol Alcohol 2017 May;52(3):383-389
    Faculty of Medicine, Department of Clinical Sciences Lund, Lund University, Gastroenterology and Hepatology, Box 117, 22100 Lund, Sweden.
    Aims: We aimed to evaluate the potential relation between the incidence of (alcoholic and non-alcoholic) acute pancreatitis (AP) and alcohol consumption in the general population, and whether the occurrence of AP shows any seasonal variation, particularly in relation to periods with expected increased alcohol consumption.

    Methods: All patients with first-time AP between 2003 and 2012 in a well-defined area in Sweden were retrospectively identified. Data on AP aetiology (alcoholic and non-alcoholic) and severity were registered. Read More

    Joint Effects of the Epigenetic Alteration of Neurotrophins and Cytokine Signaling: A Possible Exploratory Model of Affective Symptoms in Alcohol-Dependent Patients?
    Alcohol Alcohol 2017 May;52(3):277-281
    Department of Psychiatry, Social Psychiatry and Psychotherapy, Medical School Hanover, Carl-Neuberg-Str. 1, 30625 Hannover, Center for Addiction Research (CARe), Germany.
    Aims: Neurotrophins have been linked to the symptomatology of alcohol dependence. We aimed to investigate a possible association between the methylation of the promoters of both neurotrophins, the serum levels of the cytokines and core symptoms of alcohol dependence as withdrawal severity and anxiety.

    Methods: In this study we investigated a possible association between alterations in the methylation of the BDNF IV/NGF I gene promoter and the cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in 55 male alcohol-dependent patients. Read More

    Alcohol Consumption and Binge Drinking in Young Men as Predictors of Body Composition Changes During Military Service.
    Alcohol Alcohol 2017 May;52(3):365-371
    Center for Life Course Health Research, University of Oulu, Aapistie 5/PO Box 5000, Oulu FIN-90014, Finland.
    Aims: To evaluate the influences of alcohol consumption frequency and binge drinking on changes in the body composition, lifestyle habits and physical fitness of healthy young men during military service.

    Methods: A population-based study of men performing their military service in the Sodankylä Jaeger Brigade, Finland in 2005. Body composition, fitness and lifestyle habits were evaluated at baseline and 6-12 months follow-up. Read More

    Promoter Polymorphism rs886205 Genotype Interacts With DNA Methylation of the ALDH2 Regulatory Region in Alcohol Dependence.
    Alcohol Alcohol 2017 May;52(3):269-276
    Laboratory for Molecular Neuroscience, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School (MHH), 30625 Hannover, Germany.
    Aims: Aldehyde dehydrogenase 2 (ALDH2) protects cells from ethanol toxicity by metabolizing acetaldehyde. We studied the single nucleotide polymorphism (SNP) rs886205s located between a negative and a positive regulating promoter element in the ALDH2 gene. The negative regulatory region was already associated with differential DNA methylation in the two allele variations of rs886205 SNP. Read More

    Typology and Dynamics of Heavier Drinking Styles in Great Britain: 1978-2010.
    Alcohol Alcohol 2017 May;52(3):372-381
    Department of Psychology, University of Sheffield, Cathedral Court, 1 Vicar Lane, Sheffield, S1 2LT, UK.
    Aims: To identify a typology of heavier drinking styles in Great Britain and to identify socio-demographic trends in the typology over the period 1978-2010.

    Methods: We applied multiple correspondence analysis and agglomerative hierarchical clustering to beverage-specific quantity-frequency measures of alcohol consumption in the repeated cross-sectional General Lifestyle Survey of Great Britain, 1978-2010. The cluster analysis focuses on the 60,043 adult respondents over this period reporting average drinking levels above the UK Government guidelines. Read More

    The Association Between Health Changes and Cessation of Alcohol Consumption.
    Alcohol Alcohol 2017 May;52(3):344-350
    Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
    Aims: To assess whether health changes affect cessation of alcohol consumption and to compare the health status of former drinkers and abstainers.

    Methods: Cohort data from 9001 Korean participants aged 40-69 years old were analyzed. Alcohol consumption was assessed every 2 years for 10 years. Read More

    The Association Between Alcohol-Flavoured Non-Alcoholic Beverages and Alcohol Use in Japanese Adolescents.
    Alcohol Alcohol 2017 May;52(3):351-357
    Division of Environmental and Preventive Medicine, Department of Social Medicine, Faculty of Medicine, Tottori University, Nishi-machi 86, Yonago-shi, Tottori 683-8503, Japan.
    Aims: There are no legal regulations in Japan governing minors' consumption of alcohol-flavoured non-alcoholic beverages (AFNAB); therefore, we examined if their consumption could lead to increased alcohol use among adolescents in Japan.

    Methods: This cross-sectional study used a nonclinical, nationally representative sample of 38,494 junior (19,662 boys) and 61,556 senior (31,925 boys) high school students recruited in 2012. We measured AFNAB consumption rates and the order that adolescents first consumed AFNAB and alcohol. Read More

    The Intensity of Brief Interventions in Patients with Acute Alcoholic Pancreatitis Should be Increased, Especially in Young Patients with Heavy Alcohol Consumption.
    Alcohol Alcohol 2017 Jul;52(4):453-459
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, 33521 Tampere, Finland.
    Aims: After the first acute alcoholic pancreatitis (AAP), active repeated brief interventions (BIs) have been shown to protect against recurrent acute pancreatitis (RAP). However, in daily hospital practice the treatment of alcohol problems varies. Our aim was to study BIs performed in the clinic during AAP and whether this prevents from future RAP episodes. Read More

    Are Changes in Alcohol Consumption Among Swedish Youth Really Occurring 'in Concert'? A New Perspective Using Quantile Regression.
    Alcohol Alcohol 2017 Jul;52(4):487-495
    Department of Public Health Sciences, Karolinska Institutet, Solnavägen 1, 171 77, Stockholm, Sweden.
    Aims: Recent studies of youth alcohol consumption indicate a collective downward drinking trend at all levels of consumption, i.e. reductions occurring 'in concert'. Read More

    Use of Psychoactive Medication in Short- and Long-term Abstainers from Alcohol.
    Alcohol Alcohol 2017 Jul;52(4):447-452
    Service d'Addictologie, CHRU Caremeau, Place du Pr R. Debré 30029, Nîmes, France.
    Aim: To document the use of prescribed psychoactive medicines in France in patients recovering from alcohol use disorders (AUDs).

    Method: Survey among short- and long-term abstainers attending groups of French self-help associations for AUDs, recording socio-demographic profile, duration of abstinence, prescription of psychoactive medication and attitudes towards that, and whether or not in medical or psychological follow-up for AUD.

    Result: Five hundred seventy-five abstainers participated. Read More

    Associations Between Personality and Drinking Motives Among Abstinent Adult Alcoholic Men and Women.
    Alcohol Alcohol 2017 Jul;52(4):496-505
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA.
    Aims: Men and women differ in personality characteristics and may be motivated to use alcohol for different reasons. The goals of the present study were to characterize personality and drinking motives by gender and alcoholism status in adults, and to determine how alcoholism history and gender are related to the associations between personality traits and drinking motivation.

    Methods: Personality characteristics were assessed with the Eysenck Personality Questionnaire, which includes Extraversion, Neuroticism, Psychoticism and Lie (Social Conforming) scales. Read More

    Screening for At-Risk Alcohol Consumption in Primary Care: A Randomized Evaluation of Screening Approaches.
    Alcohol Alcohol 2017 May;52(3):312-317
    Addictions Department, National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8BB, UK.
    Aims: The aim of the study was to explore the relative efficiency and effectiveness of targeted versus universal screening for at-risk alcohol use in a primary care population in the UK.

    Methods: The study was a randomized evaluation of screening approach (targeted versus universal) for consecutive attendees at primary care aged 18 years or more. Targeted screening involved screening any patient attending with one of the targeted presentations, conditions associated with excessive alcohol consumption: mental health, gastrointestinal, hypertension, minor injuries or a new patient registration. Read More

    Feasibility of Studying a Brief Intervention to Help Chinese Villagers with Problem Alcohol Use After an Earthquake.
    Alcohol Alcohol 2017 Jul;52(4):472-476
    Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
    Aim: To evaluate the feasibility of conducting a study of structured brief intervention (BI) for reducing problem alcohol use among individuals who experienced earthquake.

    Methods: Following the Wenchuan earthquake, 1336 clients from 18 local hospitals were invited to complete the Alcohol Use Disorders Identification Test (AUDIT). Of those, 239 individuals (AUDIT score of greater than or equal to 7) were included in the study. Read More

    Effects of Alcohol Dependence Severity on Neural Correlates of Delay Discounting.
    Alcohol Alcohol 2017 Jul;52(4):506-515
    Department of Psychology, University of California, Los Angeles, CA, USA.
    Aims: The current study examines the relationship between alcohol dependence severity and delay discounting neural activation.

    Methods: Participants (N = 17; 6 female) completed measures of alcohol use and severity and a functional magnetic resonance imaging version of a delay discounting task.

    Results: Alcohol dependence severity was negatively associated with activation in superior frontal gyrus during impulsive relative to delayed decisions, and positively associated with activation in paracingulate gyrus and frontal pole in delayed relative to impulsive decisions. Read More

    Long-Term Mortality of Patients with an Alcohol-Related Wernicke-Korsakoff Syndrome.
    Alcohol Alcohol 2017 Jul;52(4):466-471
    Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Ctra. Canyet s/n, 08916 Badalona, Spain.
    Aims: To characterize a series of contemporary patients with alcohol-related Wernicke's encephalopathy (WE) or Korsakoff's syndrome (KS) and to update the current prognosis of disease.

    Methods: Retrospective and prospective study of patients diagnosed with an alcohol-related WE or KS between 2002 and 2011 in a tertiary hospital. Socio-demographic, alcohol use characteristics, signs and symptoms, co-morbidity and blood parameters were obtained at admission. Read More

    One Year Clinical Correlates of EtG Positive Urine Screening in Alcohol-Dependent Patients: A Survival Analysis.
    Alcohol Alcohol 2017 Jul;52(4):460-465
    Addictive Behaviors Unit, Clinical Neuroscience Institute, Clinic Hospital, Villarroel 170 08036, Barcelona, Spain.
    Aims: Little evidence exists supporting the efficacy of regular alcohol urine screening (RAUS) in the management of alcohol dependence, despite recent improvements in urine biomarkers. In this study, we aimed at investigating 1 year, differential clinical correlates between a positive and a negative baseline urine ethyl glucuronide (EtG) screening.

    Methods: Alcohol-dependent outpatients participating in a previous cross-sectional study where EtG and ethanol diagnostic performances were compared in a double blind design were included. Read More

    Alcohol Induces Cellular Senescence and Impairs Osteogenic Potential in Bone Marrow-Derived Mesenchymal Stem Cells.
    Alcohol Alcohol 2017 May;52(3):289-297
    Department of Orthopaedics, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215153, Jiangsu, China.
    Aims: Chronic and excessive alcohol consumption is a high-risk factor for osteoporosis. Bone marrow-derived mesenchymal stem cells (BM-MSCs) play an important role in bone formation; however, they are vulnerable to ethanol (EtOH). The purpose of this research was to investigate whether EtOH could induce premature senescence in BM-MSCs and subsequently impair their osteogenic potential. Read More

    The Impact of Zonisamide on the Development and Course of Alcohol Dependence in Rabbits. A pharmaco-EEG study.
    Alcohol Alcohol 2017 May;52(3):282-288
    Department of Pharmacodynamics, Medical University of Lodz, Muszynskiego 1, 90-405 Lódz, Poland.
    Aims: Zonisamide is a new anti-epileptic drug whose mechanism of action is associated with neurotransmission systems also involved in the pathogenesis of addiction. Recently, the role of memory processes and the hippocampus (Hp) is underlined in dependence. In our previous study, we determined that zonisamide decreases changes in hippocampal bioelectric activity induced by a single dose of ethanol. Read More

    Alcohol Consumption and Inpatient Health Service Utilization in a Cohort of Patients With Alcohol Dependence After 20 Years of Follow-up.
    Alcohol Alcohol 2017 03;52(2):227-233
    Social and Epidemiological Research (SER) Department, Centre for Addiction and Mental Health (CAMH), 33 Russell Street, Toronto, ON, M5S 2S1, Canada.
    Aims: To examine the association between drinking levels and inpatient health service utilization in people with a lifetime diagnosis of alcohol dependence.

    Methods: A longitudinal prospective study was conducted in a cohort of patients with alcohol dependence who had undergone treatment in 1987. Current results refer to the association between drinking patterns at 20-year follow-up and subsequent inpatient health service utilization. Read More

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