154 results match your criteria Alcohol Research-current Reviews[Journal]


Maternal Substance Use: Consequences, Identification, and Interventions.

Authors:
Grace Chang

Alcohol Res 2020 30;40(2):06. Epub 2020 Jun 30.

U.S. Department of Veterans Affairs Boston Healthcare System, Boston, Massachusetts.

Alcohol, tobacco, and cannabis are the substances most frequently used during pregnancy, and opioid-exposed pregnancies have increased fourfold. The purpose of this review is to describe the prevalence and consequences of prenatal exposure to alcohol, tobacco, cannabis, and opioids. Currently available screening questionnaires for prenatal substance use are summarized and contrasted with the measures available for prenatal alcohol use. Read More

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http://dx.doi.org/10.35946/arcr.v40.2.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304408PMC

Alcohol's Effects on Breast Cancer in Women.

Authors:
Jo L Freudenheim

Alcohol Res 2020 18;40(2):11. Epub 2020 Jun 18.

School of Public Health and Health Professions, University at Buffalo, Buffalo, New York.

Globally, more than 2 million new cases of breast cancer are reported annually. The United States alone has more than 496,000 new cases every year. The worldwide prevalence is approximately 6. Read More

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http://dx.doi.org/10.35946/arcr.v40.2.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295577PMC

Alcohol Use Disorder and Co-Occurring Mental Health Conditions.

Alcohol Res 2019 31;40(1). Epub 2019 Dec 31.

Ryan S. Trim, Ph.D., is an associate professor in the Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955158PMC
December 2019

Alcohol Use Disorder and Antisocial and Borderline Personality Disorders.

Alcohol Res 2019 30;40(1). Epub 2019 Dec 30.

Kenneth J. Sher, Ph.D., is a Curators' Distinguished Professor in the Department of Psychological Sciences, University of Missouri-Columbia, Columbia, Missouri.

Alcohol use disorder (AUD) frequently co-occurs with other psychiatric disorders, including personality disorders, which are pervasive, persistent, and impairing. Personality disorders are associated with myriad serious outcomes, have a high degree of co-occurrence with substance use disorders, including AUD, and incur significant health care costs. This literature review focuses on co-occurring AUD and personality disorders characterized by impulsivity and affective dysregulation, specifically antisocial personality disorders and borderline personality disorders. Read More

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http://dx.doi.org/10.35946/arcr.v40.1.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927749PMC
December 2019

Co-Occurring Alcohol Use Disorder and Anxiety: Bridging Psychiatric, Psychological, and Neurobiological Perspectives.

Alcohol Res 2019 30;40(1). Epub 2019 Dec 30.

Matt G. Kushner, Ph.D., is a professor in the Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.

A substantial number of people who have problems with alcohol also experience strong anxiety and mood problems. This article provides an overview of the evolving perspectives of this association in the context of three related disciplines-psychiatry, psychology, and neuroscience. Psychiatric and epidemiological studies show that having either an anxiety- or alcohol-related diagnosis elevates the prospective risk for developing the other disorder. Read More

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http://dx.doi.org/10.35946/arcr.v40.1.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927748PMC
December 2019

Alcohol Use Disorder and Schizophrenia or Schizoaffective Disorder.

Alcohol Res 2019 20;40(1). Epub 2019 Dec 20.

Alan I. Green, M.D., is the Raymond Sobel Professor of Psychiatry, a professor in the Department of Molecular and Systems Biology, and the chair of the Department of Psychiatry, Geisel School of Medicine at Dartmouth, as well as the director, Dartmouth Clinical and Translational Science Institute, Dartmouth College, Hanover, New Hampshire.

Schizophrenia and schizoaffective disorder are schizophrenia spectrum disorders that cause significant disability. Among individuals who have schizophrenia or schizoaffective disorder, alcohol use disorder (AUD) is common, and it contributes to worse outcomes than for those who do not have co-occurring substance use disorder. Common neurobiological mechanisms, including dysfunction in brain reward circuitry, may explain the high rates of co-occurrence of schizophrenia and AUD or other substance use disorders. Read More

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http://dx.doi.org/10.35946/arcr.v40.1.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927747PMC
December 2019

Integrating Treatment for Co-Occurring Mental Health Conditions.

Alcohol Res 2019 10 1;40(1). Epub 2019 Jan 1.

., is a psychiatrist at Massachusetts General Hospital and an assistant professor of psychiatry at Harvard Medical School, Boston, Massachusetts. ., is a psychologist at Massachusetts General Hospital and a professor of psychiatry at Harvard Medical School, Boston, Massachusetts.

Given the high co-occurrence between alcohol use disorder (AUD) and mental health conditions (MHCs), and the increased morbidity associated with the presence of co-occurring disorders, it is important that co-occurring disorders be identified and both disorders addressed in integrated treatment. Tremendous heterogeneity exists among individuals with co-occurring conditions, and factors related to both AUD and MHCs, including symptom type and acuity, illness severity, the chronicity of symptoms, and recovery capital, should be considered when recommending treatment interventions. This article reviews the prevalence of co-occurring AUD and MHCs, screening tools to identify individuals with symptoms of AUD and MHCs, and subsequent assessment of co-occurring disorders. Read More

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http://dx.doi.org/10.35946/arcr.v40.1.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799972PMC
October 2019

Biobehavioral Interactions Between Stress and Alcohol.

Alcohol Res 2019 10 1;40(1). Epub 2019 Jan 1.

Marcus M. Weera, Ph.D., is a postdoctoral fellow in the Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Nicholas W. Gilpin, Ph.D., is a professor in the Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

In this review, the effects of stress on alcohol drinking are discussed. The interactions between biological stress systems and alcohol drinking are examined, with a focus on the hypothalamic pituitary adrenal axis, corticotropin releasing factor, dynorphin, neuropeptide Y, and norepinephrine systems. Findings from animal models suggest that these biological stress systems may be useful targets for medications development for alcohol use disorder and co-occurring stress-related disorders in humans. Read More

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http://dx.doi.org/10.35946/arcr.v40.1.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799955PMC
October 2019

Alcohol Use Disorder and Depressive Disorders.

Alcohol Res 2019 10 1;40(1). Epub 2019 Jan 1.

R. Kathryn McHugh, Ph.D., is an assistant professor in the Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, and an associate psychologist in the Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts. Roger D. Weiss, M.D., is a professor in the Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, and the chief of the Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts.

Alcohol use disorder (AUD) and depressive disorders are among the most prevalent psychiatric disorders and co-occur more often than expected by chance. The aim of this review is to characterize the prevalence, course, and treatment of co-occurring AUD and depressive disorders. Studies have indicated that the co-occurrence of AUD and depressive disorders is associated with greater severity and worse prognosis for both disorders. Read More

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http://dx.doi.org/10.35946/arcr.v40.1.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799954PMC
October 2019

Binge Drinking's Effects on the Body.

Alcohol Res 2018 ;39(1):99-109

Patricia E. Molina, M.D., Ph.D., is the Richard Ashman, Ph.D., Professor; head of the Department of Physiology; and director of the Comprehensive Alcohol-HIV/AIDS Research Center and the Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Steve Nelson, M.D., is the John H. Seabury Professor of Medicine and the dean of the School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Studies have focused on the effects of chronic alcohol consumption and the mechanisms of tissue injury underlying alcoholic hepatitis and cirrhosis, with less focus on the pathophysiological consequences of binge alcohol consumption. Alcohol binge drinking prevalence continues to rise, particularly among individuals ages 18 to 24. However, it is also frequent in individuals ages 65 and older. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104963PMC
October 2019
31 Reads

Effects of Binge Drinking on the Developing Brain.

Alcohol Res 2018 ;39(1):87-96

Scott A. Jones and Jordan M. Lueras are graduate students in the Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon. Bonnie J. Nagel, Ph.D., is an associate professor in the Departments of Behavioral Neuroscience and Psychiatry, Oregon Health & Science University, Portland, Oregon.

Binge drinking is a pattern of alcohol drinking that raises a person's blood alcohol concentration to at least .08%, which amounts to consuming five alcoholic drinks for men and four alcoholic drinks for women in about 2 hours. It is the most common form of alcohol misuse in adolescents and young adults. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104956PMC
October 2019
4 Reads

Binge Drinking's Effects on the Developing Brain-Animal Models.

Alcohol Res 2018 ;39(1):77-86

Susanne Hiller-Sturmhöfel, Ph.D., is a science writer and editor affiliated with CSR Inc., Arlington, Virginia. Linda Patia Spear, Ph.D., is a distinguished professor, Department of Psychology, State University of New York, and the director of the Developmental Exposure Alcohol Research Center, Binghamton University, Binghamton, New York.

Adolescence typically is a time of experimentation, including alcohol use and, particularly, binge drinking. Because the brain is still developing during adolescence, such exposure could have long-lasting effects. Animal models and adolescent intermittent ethanol exposure (AIE) paradigms have been used to help elucidate the consequences of adolescent binge drinking. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104958PMC
October 2019
3 Reads

Gender Differences in Binge Drinking.

Alcohol Res 2018 ;39(1):57-76

Richard W. Wilsnack, Ph.D., is a professor emeritus in the Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota. Sharon C. Wilsnack, Ph.D., is the Chester Fritz Distinguished Professor in the Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota. Gerhard Gmel, Ph.D., is a professor, University of Lausanne, and is affiliated with the Alcohol Treatment Center, University of Lausanne Hospital, Lausanne, Switzerland. He is also an invited professor, University of the West of England, Bristol, United Kingdom. Lori Wolfgang Kantor, M.A., is a science writer at CSR, Incorporated.

Just as binge drinking rates differ for men and women, the predictors and consequences of binge drinking vary by gender as well. This article examines these differences and how binge drinking definitions and research samples and methods may influence findings. It also describes the relationship between age and binge drinking among men and women, and how drinking culture and environment affect this relationship. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104960PMC
October 2019
3 Reads

High-Intensity Drinking.

Alcohol Res 2018 ;39(1):49-55

Megan E. Patrick, Ph.D., is a research associate professor at the University of Michigan Institute for Social Research, Ann Arbor, Michigan. Beth Azar, M.A., is a science writer for Alcohol Research: Current Reviews.

Binge drinking thresholds have long been set at four or more drinks for women and five or more drinks for men over the course of a few hours. However, a significant number of people regularly consume much higher amounts of alcohol: double or even triple the standard binge drinking threshold. Researchers have begun to distinguish between typical binge drinking and this kind of "high-intensity drinking," which is common among certain types of binge drinkers and is often associated with special occasions, including holidays, sporting events, and, notably, 21st birthdays. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104968PMC
October 2019
3 Reads

NIAAA's College Alcohol Intervention Matrix.

Alcohol Res 2018 ;39(1):43-47

Jessica M. Cronce, Ph.D., is an assistant professor in the Department of Counseling Psychology and Human Services, College of Education, University of Oregon, Eugene, Oregon. Traci L. Toomey, Ph.D., is a professor in the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota. Kathleen Lenk, M.P.H., is a senior research fellow in the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota. Toben F. Nelson, Sc.D., is an associate professor in the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota. Jason R. Kilmer, Ph.D., is an assistant director of Health and Wellness for Alcohol and Other Drug Education and an associate professor in the Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, Washington. Mary E. Larimer, Ph.D., is a professor in the Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, Washington.

The College Alcohol Intervention Matrix (CollegeAIM) is a user-friendly, interactive decision tool based on a synthesis of the substantial and growing literature on campus alcohol use prevention. It includes strategies targeted at both the individual and environmental levels. Commissioned by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), CollegeAIM reflects the collective knowledge of 16 separate experts in the field, which makes it unique relative to other summaries of the science. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104959PMC
October 2019
4 Reads

"Maturing Out" of Binge and Problem Drinking.

Alcohol Res 2018 ;39(1):31-42

Matthew R. Lee, Ph.D., is research assistant professor, Department of Psychological Sciences, University of Missouri, Columbia, Missouri. Kenneth J. Sher, Ph.D., is curators' distinguished professor, Department of Psychological Sciences, University of Missouri, Columbia, Missouri.

This article reviews literature aiming to explain the widespread reductions in binge and problem drinking that begin around the transition to young adulthood (i.e., "maturing out"). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104962PMC
October 2019
4 Reads

The Epidemiology of Binge Drinking Among College-Age Individuals in the United States.

Alcohol Res 2018 ;39(1):23-30

Heather Krieger, M.A., is a graduate student; Chelsie M. Young, Ph.D., is a post-doctoral researcher; Amber M. Anthenien, M.S., is a graduate student; and Clayton Neighbors, Ph.D., is a professor, all in the Department of Psychology, University of Houston, Houston, Texas.

Rates of alcohol consumption continue to be a concern, particularly for individuals who are college age. Drinking patterns have changed over time, with the frequency of binge drinking (consuming four/five or more drinks for women/men) remaining high (30% to 40%). Young adults in the college age range are developmentally and socially at higher risk for drinking at binge levels. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104967PMC
October 2019
28 Reads

Drinking Patterns and Their Definitions.

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Alcohol Res 2018 ;39(1):17-18

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104961PMC
October 2019
2 Reads

Adolescent Binge Drinking.

Alcohol Res 2018 ;39(1):5-15

Tammy Chung, Ph.D., is an associate professor; Rachel Bachrach, Ph.D., is a postdoctoral fellow; Duncan B. Clark, M.D., Ph.D., is a professor; and Christopher S. Martin, Ph.D., is an associate professor, all in the Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Kasey G. Creswell, Ph.D., is an assistant professor in the Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania.

Binge drinking, commonly defined as consuming five or more standard drinks per occasion for men and four or more drinks for women, typically begins in adolescence. Adolescents, although they may drink less often, tend to consume higher quantities of alcohol per occasion compared with adults. This developmental difference in pattern of alcohol consumption may result, in part, from maturational changes that involve an adolescent-specific sensitivity to certain alcohol effects and greater propensity for risk-taking behaviors, such as binge drinking. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104966PMC
October 2019
2 Reads

Binge Drinking.

Alcohol Res 2018 ;39(1):1-3

Aaron M. White, Ph.D., is a senior scientific adviser to the director, Office of the Director, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland. Susan Tapert, Ph.D., is a professor of psychiatry in the School of Medicine, University of California, San Diego, California. Shivendra D. Shukla, Ph.D., is the Margaret Proctor Mulligan Endowed Professor in Medical Research at the School of Medicine, University of Missouri, Columbia, Missouri.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104965PMC
October 2019
6 Reads

Pharmacotherapy for Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder: Targeting the Opioidergic, Noradrenergic, Serotonergic, and GABAergic/Glutamatergic Systems.

Alcohol Res 2018 ;39(2):193-205

Terril L. Verplaetse, Ph.D., is an associate research scientist in the Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut. Sherry A. McKee, Ph.D., is a professor of psychiatry at the Yale School of Medicine, New Haven, Connecticut. Ismene L. Petrakis, M.D., is a professor of psychiatry at the Yale School of Medicine, New Haven, Connecticut.

Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are highly comorbid, and treatment outcomes are worse in individuals with both disorders. Several neurobiological systems have been implicated in the development and maintenance of AUD and PTSD, and pharmacologic interventions targeting these systems for singular diagnoses of AUD or PTSD have proven effective. However, there are no established treatments for co-occurring AUD and PTSD, and relatively few studies have examined potential pharmacotherapy for treating symptoms of both AUD and PTSD in comorbid populations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561397PMC
October 2019
3 Reads

Behavioral Treatments for Alcohol Use Disorder and Post-Traumatic Stress Disorder.

Alcohol Res 2018 ;39(2):181-192

Julianne C. Flanagan, Ph.D., is an associate professor in the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina. Jennifer L. Jones, M.D., is a postdoctoral fellow in the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina. Amber M. Jarnecke, Ph.D., is a postdoctoral fellow in the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina. Sudie E. Back, Ph.D., is a professor in the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, and a staff psychologist at the Ralph H. Johnson VA Medical Center, Charleston, South Carolina.

Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are highly prevalent and debilitating psychiatric conditions that commonly co-occur. Individuals with comorbid AUD and PTSD incur heightened risk for other psychiatric problems (e.g. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561400PMC
October 2019
2 Reads

Alcohol Use Disorder and Traumatic Brain Injury.

Alcohol Res 2018 ;39(2):171-180

Zachary M.Weil, Ph.D., is an assistant professor in the Center for Brain and Spinal Cord Repair and Group in Behavioral Neuroendocrinology, Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio. John D. Corrigan, Ph.D., is a professor in the Department of Physical Medicine and Rehabilitation, Ohio State University Wexner Medical Center, Columbus, Ohio. Kate Karelina, Ph.D., is a research scientist in the Center for Brain and Spinal Cord Repair and Group in Behavioral Neuroendocrinology, Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio.

Alcohol use and traumatic brain injury (TBI) are inextricably and bidirectionally linked. Alcohol intoxication is one of the strongest predictors of TBI, and a substantial proportion of TBIs occur in intoxicated individuals. An inverse relationship is also emerging, such that TBI can serve as a risk factor for, or modulate the course of, alcohol use disorder (AUD). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561403PMC
October 2019
16 Reads

Co-Occurring Post-Traumatic Stress Disorder and Alcohol Use Disorder in U.S. Military and Veteran Populations.

Alcohol Res 2018 ;39(2):161-169

Emily R. Dworkin, Ph.D., is a postdoctoral fellow in the Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington. Hannah E. Bergman, Ph.D., is a postdoctoral fellow in the School of Social Work, University of Washington, Seattle, Washington. Thomas O. Walton, M.S.W., is a graduate student in the School of Social Work, University of Washington, Seattle, Washington. Denise D. Walker, Ph.D., is an associate professor in the School of Social Work, University of Washington, Seattle, Washington. Debra L. Kaysen, Ph.D., is a professor in the Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.

Co-occurring post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are costly and consequential public health problems that negatively affect the health and well-being of U.S. military service members and veterans. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561402PMC
October 2019
6 Reads

Early Life Stress as a Predictor of Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder.

Alcohol Res 2018 ;39(2):147-159

Richard S. Lee, Ph.D., is an assistant professor in the Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland. Lynn M. Oswald, Ph.D., R.N., is an associate professor in the Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, Maryland. Gary S. Wand, M.D., is a professor in the Departments of Psychiatry and Behavioral Sciences and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

During the critical developmental periods of childhood when neural plasticity is high, exposure to early life stress (ELS) or trauma may lead to enduring changes in physiological stress systems and enhanced vulnerability for psychopathological conditions such as post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) in adulthood. Clinical and preclinical studies have sought to understand the possible mechanisms linking ELS, PTSD, and AUD. Preclinical studies have employed animal models of stress to recapitulate PTSD-like behavioral deficits and alcohol dependence, providing a basic framework for identifying common physiological mechanisms that may underlie these disorders. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561395PMC
October 2019
19 Reads

Common Biological Mechanisms of Alcohol Use Disorder and Post-Traumatic Stress Disorder.

Alcohol Res 2018 ;39(2):131-145

Junghyup Suh, Ph.D., is an instructor in the Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, and an assistant neuroscientist in the Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, Massachusetts. Kerry J. Ressler, M.D., Ph.D., is a professor in the Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, and the chief scientific officer and chief of the Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, Massachusetts.

Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid. Although recent clinical studies provide some understanding of biological and subsequent behavioral changes that define each of these disorders, the neurobiological basis of interactions between PTSD and AUD has not been well-understood. In this review, we summarize the relevant animal models that parallel the human conditions, as well as the clinical findings in these disorders, to delineate key gaps in our knowledge and to provide potential clinical strategies for alleviating the comorbid conditions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561401PMC
October 2019
3 Reads

Functional and Psychiatric Correlates of Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder.

Alcohol Res 2018 ;39(2):121-129

Elizabeth Straus, Ph.D., is a postdoctoral research fellow at VA San Diego Healthcare System and in the Department of Psychiatry, University of California San Diego School of Medicine, San Diego, California. Moira Haller, Ph.D., is a clinical psychologist at VA San Diego Healthcare System and an assistant clinical professor in the Department of Psychiatry, University of California San Diego School of Medicine, San Diego, California. Robert C. Lyons, M.S., is a graduate student in the Joint Doctoral Program in Clinical Psychology at San Diego State University and the University of California, San Diego, California. Sonya B. Norman, Ph.D., is a professor in the Department of Psychiatry, University of California San Diego School of Medicine, San Diego, California, and the director of the PTSD Consultation Program at the National Center for PTSD, White River Junction, Vermont.

Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are common comorbid conditions that affect large segments of the population. Individuals with comorbid PTSD/AUD face greater clinical and functional stressors than those with diagnoses of either PTSD or AUD alone. The purpose of this article is to review the phenomenology and functional associations of PTSD/AUD and address the common social, occupational, and psychological concerns associated with both disorders. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561399PMC
October 2019
2 Reads

The Epidemiology of Post-Traumatic Stress Disorder and Alcohol Use Disorder.

Alcohol Res 2018 ;39(2):113-120

Nathan D. L. Smith, A.L.M., is a doctoral student in the Department of Epidemiology, University of Florida, Gainesville, Florida. Linda B. Cottler, Ph.D., M.P.H., F.A.C.E., is the dean's professor in the Department of Epidemiology, University of Florida, Gainesville, Florida.

For more than 40 years, research has shown that individuals with post-traumatic stress disorder (PTSD) use alcohol and experience alcohol use disorder (AUD) to a greater degree than those with no PTSD. AUD and PTSD have shown a durable comorbidity that has extended through decades and through changes in disorder definitions. Some research shows that veterans who have experienced PTSD have a high likelihood of developing AUD, perhaps reflecting the self-medication hypothesis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561398PMC
October 2019
3 Reads

Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder.

Alcohol Res 2018 ;39(2):111-112

Robert M. Anthenelli, M.D., is a professor and the executive vice chair for the Department of Psychiatry, University of California San Diego, La Jolla, California. Kathleen T. Brady, M.D., Ph.D., is a distinguished university professor, the vice president for research, and the director of the South Carolina Clinical and Translational Research Institute, Medical University of South Carolina, Charleston, South Carolina. Lindsey Grandison, Ph.D., National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland. Deidra Roach, M.D., is a medical project officer in the Division of Treatment and Recovery Research, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561396PMC
October 2019
3 Reads

Development, Prevention, and Treatment of Alcohol-Induced Organ Injury: The Role of Nutrition.

Alcohol Res 2017 ;38(2):289-302

Shirish Barve, Ph.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology; Shao-Yu Chen, Ph.D., is a Professor in the Department of Pharmacology and Toxicology; Irina Kirpich, Ph.D., and Walter H. Watson, Ph.D., both are Assistant Professors in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and in the Department of Pharmacology and Toxicology; all at the University of Louisville School of Medicine, Louisville, Kentucky. Craig McClain, M.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology at the University of Louisville School of Medicine, Louisville, Kentucky, and a Staff Physician at the Robley Rex Veterans Medical Center, Louisville, Kentucky.

Alcohol and nutrition have the potential to interact at multiple levels. For example, heavy alcohol consumption can interfere with normal nutrition, resulting in overall malnutrition or in deficiencies of important micronutrients, such as zinc, by reducing their absorption or increasing their loss. Interactions between alcohol consumption and nutrition also can affect epigenetic regulation of gene expression by influencing multiple regulatory mechanisms, including methylation and acetylation of histone proteins and DNA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513692PMC
May 2018
190 Reads

Alcohol Misuse and Kidney Injury: Epidemiological Evidence and Potential Mechanisms.

Alcohol Res 2017 ;38(2):283-288

Zoltan V. Varga, M.D., Ph.D., is a visiting Research Fellow; Csaba Matyas, M.D., is a visiting Research Fellow; Janos Paloczi, Ph.D., is a visiting Research Fellow; and Pal Pacher, M.D., Ph.D., is a Senior Investigator and Lab Chief, all in the Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.

Chronic alcohol consumption is a well-known risk factor for tissue injury. The link between alcohol use disorder (AUD) and kidney injury is intriguing but controversial, and the molecular mechanisms by which alcohol may damage the kidneys are poorly understood. Epidemiological studies attempting to link AUD and kidney disease are, to date, inconclusive, and there is little experimental evidence directly linking alcohol consumption to kidney injury. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513691PMC
May 2018
67 Reads

Alcohol and Puberty.

Alcohol Res 2017 ;38(2):277-282

William L. Dees, Ph.D., is a Professor; Jill K. Hiney, Ph.D., is a Research Assistant Professor; and Vinod K. Srivastava, Ph.D., is a Research Associate Professor, all in the Department of Veterinary Integrative Sciences, College of Veterinary Medicine, Texas A&M University, College Station, Texas.

Adolescence represents a vulnerable period for developing youth. Alcohol use and misuse are especially problematic behaviors during this time. Adolescents are more sensitive to alcohol and less tolerant of its detrimental effects than are adults. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513690PMC
May 2018
4 Reads

Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System.

Alcohol Res 2017 ;38(2):255-276

Nadia Rachdaoui, Ph.D., is an Assistant Research Professor, and Dipak K. Sarkar, Ph.D., D.Phil., is Board of Governors Distinguished Professor, in the Rutgers Endocrine Research Program, Department of Animal Sciences, Rutgers University, New Brunswick, New Jersey.

Alcohol can permeate virtually every organ and tissue in the body, resulting in tissue injury and organ dysfunction. Considerable evidence indicates that alcohol abuse results in clinical abnormalities of one of the body's most important systems, the endocrine system. This system ensures proper communication between various organs, also interfacing with the immune and nervous systems, and is essential for maintaining a constant internal environment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513689PMC
May 2018
8 Reads

Alcohol and the Lung.

Alcohol Res 2017 ;38(2):243-254

Ashish J. Mehta, M.D., is an Assistant Professor of Medicine in the Department of Medicine, Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University, Atlanta, Georgia, and a Staff Physician at the Atlanta VA Medical Center, Decatur, Georgia. David M. Guidot, M.D., is a Professor of Medicine in the Department of Medicine, Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University, Atlanta, Georgia, and a Staff Physician at the Atlanta VA Medical Center, Decatur, Georgia.

Among the many organ systems affected by harmful alcohol use, the lungs are particularly susceptible to infections and injury. The mechanisms responsible for rendering people with alcohol use disorder (AUD) vulnerable to lung damage include alterations in host defenses of the upper and lower airways, disruption of alveolar epithelial barrier integrity, and alveolar macrophage immune dysfunction. Collectively, these derangements encompass what has been termed the "alcoholic lung" phenotype. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513688PMC
May 2018
21 Reads

Alcohol's Effects on the Cardiovascular System.

Authors:
Mariann R Piano

Alcohol Res 2017 ;38(2):219-241

Mariann R. Piano, Ph.D., is a Professor in and Department Head of the Department of Biobehavioral Health Science, University of Illinois at Chicago, Chicago, Illinois.

Alcohol use has complex effects on cardiovascular (CV) health. The associations between drinking and CV diseases such as hypertension, coronary heart disease, stroke, peripheral arterial disease, and cardiomyopathy have been studied extensively and are outlined in this review. Although many behavioral, genetic, and biologic variants influence the interconnection between alcohol use and CV disease, dose and pattern of alcohol consumption seem to modulate this most. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513687PMC
May 2018
5 Reads

Alcoholic Myopathy: Pathophysiologic Mechanisms and Clinical Implications.

Alcohol Res 2017 ;38(2):207-217

Liz Simon, M.V.Sc., Ph.D., is an Assistant Professor in the Department of Physiology, Alcohol and Drug Abuse Center of Excellence; Sarah E. Jolley, M.D., M.Sc., is an Assistant Professor in the Division of Critical Care Medicine; and Patricia E. Molina, M.D., Ph.D., is the Richard Ashman, Ph.D. Professor and Department Head of Physiology, and Director of the Comprehensive Alcohol-HIV/AIDS Research Center and Alcohol and Drug Abuse Center of Excellence, all at the Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Skeletal muscle dysfunction (i.e., myopathy) is common in patients with alcohol use disorder. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513686PMC
May 2018
5 Reads

Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models.

Alcohol Res 2017 ;38(2):183-206

Natalie M. Zahr, Ph.D., is a Research Scientist in the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California; and Program Director of Translational Imaging, Neuroscience Program, SRI International, Menlo Park, California. Adolf Pfefferbaum, M.D., is Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine, Stanford, California; and Distinguished Scientist and Center Director of the Neuroscience Program, SRI International, Menlo Park, California.

Brain imaging technology has allowed researchers to conduct rigorous studies of the dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain insights into the effects of chronic alcoholism on the human brain. Magnetic resonance imaging (MRI) studies have distinguished alcohol-related brain effects that are permanent from those that are reversible with abstinence. In support of postmortem neuropathological studies showing degeneration of white matter, MRI studies have shown a specific vulnerability of white matter to chronic alcohol exposure. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513685PMC
May 2018
11 Reads

Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease.

Alcohol Res 2017 ;38(2):173-182

Veronica Wendy Setiawan, Ph.D., is an Assistant Professor at the Keck School of Medicine, University of Southern California, Los Angeles, California. Kristine Monroe, Ph.D., is an Associate Professor, at the Keck School of Medicine, University of Southern California, Los Angeles, California. Aurelia Lugea, Ph.D., is an Associate Professor at Cedars-Sinai Medical Center, Los Angeles, California. Dhiraj Yadav, M.D., M.P.H., is a Professor of Medicine in the Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Stephen J. Pandol, M.D., is Director of Basic and Translational Pancreas Research at Cedars-Sinai Medical Center, Los Angeles, California.

Findings from epidemiologic studies and research with experimental animal models provide insights into alcohol-related disease pathogeneses. Epidemiologic data indicate that heavy drinking and smoking are associated with high rates of pancreatic disease. Less clear is the association between lower levels of drinking and pancreatitis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513684PMC
May 2018
5 Reads

Alcohol and Gut-Derived Inflammation.

Alcohol Res 2017 ;38(2):163-171

Faraz Bishehsari, M.D., Ph.D., is an Assistant Professor; Garth Swanson, M.D., is an Assistant Professor; Vishal Desai, M.D., is a Physician; Robin M. Voigt, Ph.D., is an Assistant Professor; Christopher B. Forsyth, Ph.D., is an Associate Professor; and Ali Keshavarzian, M.D., is a Professor, all in the Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois. Emmeline Magno, M.D., is an Internist in the Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.

In large amounts, alcohol and its metabolites can overwhelm the gastrointestinal tract (GI) and liver and lead to damage both within the GI and in other organs. Specifically, alcohol and its metabolites promote intestinal inflammation through multiple pathways. That inflammatory response, in turn, exacerbates alcohol-induced organ damage, creating a vicious cycle and leading to additional deleterious effects of alcohol both locally and systemically. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513683PMC
May 2018
4 Reads

Alcoholic Liver Disease: Pathogenesis and Current Management.

Alcohol Res 2017 ;38(2):147-161

Natalia A. Osna, Ph.D., is a Research Biologist in the Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, and an Associate Professor in the Department of Internal Medicine, University of Nebraska Medical Center, both in Omaha, Nebraska. Terrence M. Donohue, Jr., Ph.D., is a Research Biochemist in the Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, and a Professor in the Departments of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, both in Omaha, Nebraska. Kusum K. Kharbanda, Ph.D., is a Research Biologist in the Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, and a Professor in the Departments of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, both in Omaha, Nebraska.

Excessive alcohol consumption is a global healthcare problem. The liver sustains the greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol metabolism. Chronic and excessive alcohol consumption produces a wide spectrum of hepatic lesions, the most characteristic of which are steatosis, hepatitis, and fibrosis/cirrhosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513682PMC
May 2018
10 Reads

Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism.

Alcohol Res 2016 ;38(1):59-68

Alcohol Research: Current Reviews.

Gene variants encoding several of the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), are among the largest genetic associations with risk for alcohol dependence. Certain genetic variants (i.e. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872614PMC
July 2016
4 Reads

Nature and Treatment of Comorbid Alcohol Problems and Post Traumatic Stress Disorder Among American Military Personnel and Veterans.

Alcohol Res 2016 ;38(1):133-40

VA Mid-Atlantic Health Care Network Mental Illness Research, Education and Clinical Center Durham, North Carolina.

Many service members and veterans seeking treatment for alcohol problems also have post-traumatic stress disorder (PTSD). This article considers the effectiveness of treating alcohol problems and PTSD simultaneously. The authors begin by summarizing the extent of excessive alcohol use among military service members and veterans. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872608PMC
July 2016
10 Reads

The Influence of Gender and Sexual Orientation on Alcohol Use and Alcohol-Related Problems: Toward a Global Perspective.

Alcohol Res 2016 ;38(1):121-32

Alcohol Research: Current Reviews.

Although there are wide differences in alcohol use patterns among countries, men are consistently more likely than women to be drinkers and to drink heavily. Studies of alcohol use among sexual minorities (SMs), however, reflect a more complex picture. Such research has found higher rates of alcohol use and alcohol-related problems among SM persons than among heterosexuals and greater differences between SM and heterosexual women than between SM and heterosexual men. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872607PMC
July 2016
5 Reads

Drinking Over the Lifespan: Focus on Older Adults.

Alcohol Res 2016 ;38(1):115-20

Department of Psychiatry at the University of Michigan, Ann Arbor, Michigan.

A substantial and growing number of older adults misuse alcohol. The emerging literature on the "Baby Boom" cohort, which is now reaching older adulthood, indicates that they are continuing to use alcohol at a higher rate than previous older generations. The development and refinement of techniques to address these problems and provide early intervention services will be crucial to meeting the needs of this growing population. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872606PMC
July 2016
8 Reads

Drinking Over the Lifespan: Focus on College Ages.

Alcohol Res 2016 ;38(1):103-14

Center for Alcohol and Addiction Studies and the Department of Behavioral and Social Sciences at Brown University School of Public Health, Providence, Rhode Island.

Many college students drink heavily and experience myriad associated negative consequences. This review suggests that a developmental perspective can facilitate a better understanding of college drinking. Specifically, using an emerging adulthood framework that considers the ongoing role of parents and neurodevelopmental processes can provide insight into why students drink. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872605PMC
July 2016
18 Reads

Drinking Over the Lifespan: Focus on Early Adolescents and Youth.

Authors:
Michael Windle

Alcohol Res 2016 ;38(1):95-101

Department of Behavioral Sciences and Health Education, Emory University, Atlanta, Georgia.

Historical trends in alcohol use among U.S. adolescents, as well as data regarding alcohol-related traffic fatalities among youth, indicate decreases in alcohol use. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872619PMC
July 2016
30 Reads