961,998 results match your criteria Alcohol Fayetteville N.Y.[Journal]


Conceptualizing the UPPS-P Model of Impulsive Personality through Network Analysis: Key Dimensions and General Robustness Across Young Adulthood.

J Pers 2020 Jul 6. Epub 2020 Jul 6.

Purdue University.

Objective: Within the UPPS-P model of impulsive personality, negative urgency, positive urgency, lack of premeditation, lack of perseverance, and sensation seeking dimensions have been linked to unique etiological mechanisms and outcomes. Yet, additional research is needed exploring direct relations among dimensions to determine how these relations may contribute to the nature of impulsive personality and its correlates. The current study used network analysis to clarify relations among UPPS-P dimensions and assess global robustness of these relations across young adulthood. Read More

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http://dx.doi.org/10.1111/jopy.12572DOI Listing

Long-Term Outcome of Surgical Management in Symptomatic Pediatric Vertebral Hemangiomas Presenting With Myelopathy.

Neurosurgery 2020 Jul 6. Epub 2020 Jul 6.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Vertebral hemangiomas are benign, highly vascular lesions of the vertebra, rarely seen in the pediatric age group.

Objective: To analyze the long-term (>3 yr) outcome of patients of pediatric vertebral hemangioma presenting with myelopathy and to describe our surgical strategy to treat such cases.

Methods: All patients up to 18 yr of age with a symptomatic vertebral hemangioma treated at our hospital from May 2003 to August 2016, with at least 3-yr follow-up were included. Read More

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http://dx.doi.org/10.1093/neuros/nyaa273DOI Listing

Vincent van Gogh and his illness. A reflection on a posthumous diagnostic exercise.

Authors:
Piet Voskuil

Epilepsy Behav 2020 Jul 3;111:107258. Epub 2020 Jul 3.

Epilepsy center Dr. Hans Bergerkliniek, Breda, Netherlands. Electronic address:

Many attempts have been undertaken in the past to perform a proper diagnosis of the illness of Dutch painter Vincent van Gogh (1853-1890). Van Gogh Museum Amsterdam organized a meeting of experts on this issue in 2016. Publication of a final conclusion in a medical journal is still in progress. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107258DOI Listing

Foliar application of silicon improves stem strength under low light stress by regulating lignin biosynthesis genes in soybean (Glycine max (L.) Merr.).

J Hazard Mater 2020 Jun 21;401:123256. Epub 2020 Jun 21.

College of Agronomy, Sichuan Agricultural University, 211-Huimin Road, Wenjiang District, Chengdu 611130, PR China; Sichuan Engineering Research Center for Crop Strip Intercropping System, Key Laboratory of Crop Ecophysiology and Farming System in Southwest China (Ministry of Agriculture), Sichuan Agricultural University, Chengdu, PR China. Electronic address:

In order to improve soybean's resistance to lodging, silicon (Si) solutions at concentrations of 0,100, 200,300 mg kg were applied during the seedling stage. The Si accumulation in different parts of the plants, the photosynthetic parameters of leaves and chlorophyll content, the stem bending resistance, the expression of genes of lignin biosynthesis and associated enzyme activity and sap flow rates were measured at early and late growth stages. The potential mechanisms for how Si improve growth and shade tolerance, enhances lodging resistance and improves photosynthesis were analyzed to provide a theoretical basis for the use of Si amendments in agriculture. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123256DOI Listing

Pd-based catalysts promoted by hierarchical porous AlO and ZnO microsphere supports/coatings for ethyl acetate highly active and stable destruction.

J Hazard Mater 2020 Jun 22;401:123281. Epub 2020 Jun 22.

College of Resource and Environmental Engineering, Guizhou University, Guiyang, 550025, PR China. Electronic address:

Developing economical and active materials is of great significance for VOC purification. Here, hierarchical porous AlO and ZnO microspheres (AlO-pm and ZnO-pm) were synthesized by a facile hydrothermal strategy. The urchin-like AlO-pm and flower-like ZnO-pm possess high specific surface area (especially; external surface area) obviously boost the dispersion of Pd with 29. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123281DOI Listing

A randomised double-blind trial of cognitive training for the prevention of psychopathology in at-risk youth.

Behav Res Ther 2020 Jun 23;132:103672. Epub 2020 Jun 23.

The Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.

Background: The aim of this study was to evaluate the effectiveness of online cognitive training as a means of reducing psychopathology in at-risk youth.

Methods: In a double-blind randomised controlled trial, 228 youths (mean age = 18.6, 74. Read More

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http://dx.doi.org/10.1016/j.brat.2020.103672DOI Listing

Natural therapeutic agents for neurodegenerative diseases from the shells of Xanthoceras sorbifolium.

Bioorg Chem 2020 Jun 24;101:104038. Epub 2020 Jun 24.

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. Electronic address:

Neuroinflammation is linked to neurodegenerative diseases, manifested by the microglial-released over-production of nitric oxide (NO). However, so far there is no effective strategy regarding curing or preventing neurodegenerative diseases. Triterpene saponins from Xanthoceras sorbifolium were proved to be capable of eliciting a protective effect in neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104038DOI Listing

Methanogenic potential of diclofenac and ibuprofen in sanitary sewage using metabolic cosubstrates.

Sci Total Environ 2020 Jun 27;742:140530. Epub 2020 Jun 27.

Department of Hydraulics and Sanitation Engineering, São Carlos School of Engineering, University of São Paulo, Ave Trabalhador São-Carlense, No. 400, 13566-590 São Carlos, SP, Brazil.. Electronic address:

Diclofenac (DCF) and ibuprofen (IBU) are widely used anti-inflammatory drugs and are frequently detected in wastewater from Wastewater Treatment Plants and in aquatic environments. In this study, the methanogenic potential (P) of anaerobic sludge subjected to DCF (7.11 ± 0. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140530DOI Listing

Predictive validity of the adult tobacco dependence index: Findings from waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) study.

Drug Alcohol Depend 2020 Jun 30;214:108134. Epub 2020 Jun 30.

College of Global Public Health, New York University, United States.

Background And Aims: Building on published work establishing concurrent validity of a self-report tobacco dependence (TD) index among users of different tobacco products in Wave 1 (W1) of the Population Assessment of Tobacco and Health (PATH) Study, the current study examines prospective relationships with tobacco use behaviors to establish predictive validity of the TD index. Hypotheses suggested high levels of W1 TD would be associated with persistent tobacco use at Wave 2 (W2).

Participants: A U. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108134DOI Listing

Establishment of time-resolved fluoroimmunoassays for detection of growth hormone and insulin-like growth factor I in rainbow trout plasma.

Comp Biochem Physiol A Mol Integr Physiol 2020 Jul 3:110751. Epub 2020 Jul 3.

Department of Biological Sciences, University of Idaho, Moscow, ID, United States; Columbia River Inter-Tribal Fish Commission, Portland, Oregon.

The GH/IGF-I axis influences many aspects of salmonid life history and is involved in a variety of physiological processes that are related to somatic growth (e.g., reproduction, smoltification, and the response to fasting and stress). Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.110751DOI Listing

Association between nocturnal hypoxemia and cancer incidence in patients investigated for obstructive sleep apnea. Data from a large multicenter French cohort.

Chest 2020 Jul 3. Epub 2020 Jul 3.

Department of Respiratory and Sleep Medicine, Angers University hospital, Angers, France; INSERM Unit 1063, Angers, France. Electronic address:

Background: Previous studies have yielded inconsistent findings regarding the association between obstructive sleep apnea (OSA) and cancer in humans.

Research Question: Is there an association between indices of sleep-disordered breathing severity and cancer incidence in patients investigated for suspected OSA?

Study Design And Methods: Data from a large multicenter cohort of cancer-free patients investigated for OSA were linked to health administrative data to identify new-onset cancer. Kaplan-Meier survival analysis and Cox proportional-hazards models were used to evaluate the association of cancer incidence with OSA severity and nocturnal hypoxemia. Read More

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http://dx.doi.org/10.1016/j.chest.2020.06.055DOI Listing

Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations.

Prev Med 2020 Jul 3:106189. Epub 2020 Jul 3.

Vermont Center on Behavior and Health, University of Vermont, Burlington, VT, USA.

We examined whether elucidating underpinning smoking motivation and related pharmacological processes enhances understanding of nicotine dependence among smokers from vulnerable populations. Data were obtained between Oct, 2016 and Sept, 2019 from 745 adult smokers with co-morbid psychiatric conditions or socioeconomic disadvantage at University of Vermont, Brown University, Johns Hopkins University. Smoking motivation was assessed using the Cigarette Purchase Task (CPT), a behavioral-economic task that models the relative reinforcing value of smoking under varying monetary constraint. Read More

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http://dx.doi.org/10.1016/j.ypmed.2020.106189DOI Listing

Impact of low-level viraemia on virological failure among Asian children with perinatally acquired HIV on first-line combination antiretroviral treatment: a multicentre, retrospective cohort study.

J Int AIDS Soc 2020 Jul;23(7):e25550

Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.

Introduction: The clinical relevance of low-level viraemia (LLV) and virological outcomes among children living with HIV (CLHIV) remains controversial. This study aimed to determine the impact of LLV on virological failure (VF) among Asian CLHIV on first-line combination antiretroviral therapy (cART).

Methods: CLHIV aged <18 years, who were on first-line cART for ≥12 months, and had virological suppression (two consecutive plasma viral load [pVL] <50 copies/mL) were included. Read More

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http://dx.doi.org/10.1002/jia2.25550DOI Listing

One-pot synthesis of chiral N-arylamines by combining biocatalytic aminations with Buchwald-Hartwig N-arylation.

Angew Chem Int Ed Engl 2020 Jul 6. Epub 2020 Jul 6.

University of Manchester, Chemistry, Manchester Institute of Biotechnology, 131 Princess Street, M1 7DN, Manchester, UNITED KINGDOM.

The combination of biocatalysis and chemo-catalysis increasingly offers chemists access to more diverse chemical architectures. Here, we describe the combination of a toolbox of chiral amine producing biocatalysts with a Buchwald-Hartwig cross-coupling reaction, affording a variety of a-chiral aniline derivatives. The use of a surfactant allowed reactions to be performed sequentially in the same flask, preventing the palladium catalyst being inhibited by the high concentrations of ammonia, salts or buffers present in the aqueous media in most cases. Read More

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http://dx.doi.org/10.1002/anie.202006246DOI Listing

Safety of Gabapentin Prescribed for Any Indication in a Large Clinical Cohort of 571,718 US Veterans with and without Alcohol Use Disorder.

Alcohol Clin Exp Res 2020 Jul 6. Epub 2020 Jul 6.

Veterans Aging Cohort Study Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, 06516, USA.

Background: Gabapentin is prescribed for seizures and pain and has efficacy for treating alcohol use disorder (AUD) starting at doses of 900 milligrams per day (mg/day). Recent evidence suggests safety concerns associated with gabapentin including adverse neurologic effects. Individuals with hepatitis C (HCV), HIV or AUD may be at increased risk due to comorbidities and potential medication interactions. Read More

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http://dx.doi.org/10.1111/acer.14408DOI Listing

Chemogenetic Inactivation of Orbitofrontal Cortex Decreases Cue-Induced Reinstatement of Ethanol and Sucrose Seeking in Male and Female Wistar Rats.

Alcohol Clin Exp Res 2020 Jul 6. Epub 2020 Jul 6.

Neuroscience and Behavior Graduate Program, University of Massachusetts Amherst, Amherst, MA, 01003, United States.

Background: The orbitofrontal cortex (OFC) encodes internal representations of outcomes and subjective value to facilitate flexible reward-seeking. OFC activation is associated with drug seeking in both human subjects and animal models. OFC plays a role in alcohol use, but studies in animal models have produced conflicting results with some showing decreased seeking after OFC inactivation but others showing increased seeking or no changes. Read More

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http://dx.doi.org/10.1111/acer.14407DOI Listing

Deficiency of Intestinal α1-2-fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice.

Alcohol Clin Exp Res 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine, University of California San Diego, La Jolla, CA, USA, La Jolla.

Background: Fucosyltransferase 2 (Fut2)-mediated intestinal α1-2-fucosylation is important in maintaining a symbiotic host-microbiota relationship and can protect against several pathogens. Intestinal dysbiosis is an important factor for the progression of experimental ethanol-induced liver disease, but the role of Fut2 in modulating the intestinal glycocalyx during alcohol-associated liver disease is unknown. We investigated the role of Fut2-mediated intestinal α1-2-fucosylation for the development of alcohol-associated liver disease. Read More

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http://dx.doi.org/10.1111/acer.14405DOI Listing

Cigarette Smoking, Coffee Consumption, Alcohol Intake, and Risk of Crohn's Disease and Ulcerative Colitis: A Mendelian Randomization Study.

Inflamm Bowel Dis 2020 Jul 6. Epub 2020 Jul 6.

Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.

Background: Crohn's disease (CD) and ulcerative colitis (UC) are widely associated with smoking in epidemiological studies, whereas there are conflicting results for the association between CD and UC for both coffee and alcohol consumption. Herein, we aimed to investigate whether cigarette smoking and alcohol and coffee consumption are causally associated with either CD or UC.

Methods: We utilized 540 genome-wide significant single-nucleotide polymorphisms for 3 potentially addictive substances-nicotine, alcohol, and caffeine-to assess the association of smoking, coffee, and alcohol consumption with CD and UC (12,194 CD cases, 12,366 UC cases, and 25,042 controls of European ancestry), using Mendelian randomization analysis. Read More

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http://dx.doi.org/10.1093/ibd/izaa152DOI Listing

Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.

PLoS Med 2020 Jul 6;17(7):e1003172. Epub 2020 Jul 6.

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

Background: The "trimorbidity" of substance use disorder and mental and physical illness is associated with living in precarious housing or homelessness. The extent to which substance use increases risk of psychosis and both contribute to mortality needs investigation in longitudinal studies.

Methods And Findings: A community-based sample of 437 adults (330 men, mean [SD] age 40. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003172DOI Listing

Healthy behaviors at age 50 years and frailty at older ages in a 20-year follow-up of the UK Whitehall II cohort: A longitudinal study.

PLoS Med 2020 Jul 6;17(7):e1003147. Epub 2020 Jul 6.

Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative Diseases, France.

Background: Frailty is associated with increased risk of various health conditions, disability, and death. Health behaviors are thought to be a potential target for frailty prevention, but the evidence from previous studies is based on older populations with short follow-ups, making results susceptible to reverse causation bias. We examined the associations of healthy behaviors at age 50, singly and in combination, as well as 10-year change in the number of healthy behaviors over midlife with future risk of frailty. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003147DOI Listing

Bone Marrow Aspiration/Biopsy in the Evaluation of Fever of Unknown Origin in Patients with AIDS.

Infect Disord Drug Targets 2020 Jul 5. Epub 2020 Jul 5.

Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran. Iran.

Background: HIV can interrupt the normal development of bone marrow cell lines. Bone marrow aspiration/biopsy (BMA/B) has been described as a diagnostic tool in AIDS patients with fever of unknown origin (FUO). In this study, we aimed to study patients with AIDS who had undergone a BMA/B to investigate FUO and describe the pathologies diagnosed in the biopsy. Read More

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http://dx.doi.org/10.2174/1871526520666200705212903DOI Listing

Resveratrol and other Stilbenes: Effects on Dysregulated Gene Expression in Cancers and Novel Delivery Systems.

Anticancer Agents Med Chem 2020 Jul 5. Epub 2020 Jul 5.

Department of Agrofood and Biological Sciences, National Research Council, CNR-ISPA, Lecce. Italy.

Trans-resveratrol (RESV), pterostilbene, trans-piceid and trans-viniferins are bioactive stilbenes present in grapes and other plants. Several groups applied biotechnology to introduce their synthesis in plant crops. Biochemical interaction with enzymes, regulation of non-coding RNAs, and activation of signaling pathways and transcription factors are among the main effects described in literature. Read More

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http://dx.doi.org/10.2174/1871520620666200705220722DOI Listing

A reduction in reported alcohol use in pregnancy in Australian Aboriginal communities: a prevention campaign showing promise.

Aust N Z J Public Health 2020 Jul 6. Epub 2020 Jul 6.

Telethon Kids Institute, The University of Western Australia, Perth, Western Australia.

Objective: Aboriginal leaders in remote Western Australian communities with high rates of prenatal alcohol exposure invited researchers to evaluate the community-led Marulu foetal alcohol spectrum disorder (FASD) Prevention Strategy initiated in 2010.

Methods: The proportion of women reporting alcohol use during pregnancy to midwives was compared between 2008, 2010 and 2015. Initial midwife appointments were calculated by weeks of gestation. Read More

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http://dx.doi.org/10.1111/1753-6405.13012DOI Listing

4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.

J Cell Biochem 2020 Jul 6. Epub 2020 Jul 6.

Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan.

Elevated cellular oxidative stress and oxidative DNA damage are key contributors to impaired cardiac function in diabetes. During chronic inflammation, reactive oxygen species (ROS)-induced lipid peroxidation results in the formation of reactive aldehydes, foremost of which is 4-hydroxy-2-nonenal (4HNE). 4HNE forms covalent adducts with proteins, negatively impacting cellular protein function. Read More

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http://dx.doi.org/10.1002/jcb.29814DOI Listing

Alcoholics Anonymous and 12-Step Facilitation Treatments for Alcohol Use Disorder: A Distillation of a 2020 Cochrane Review for Clinicians and Policy Makers.

Alcohol Alcohol 2020 Jul 6. Epub 2020 Jul 6.

Veterans Affairs and Stanford University Medical Centers, Stanford University Stanford School of Medicine, Stanford, CA, USA.

Aims: A recently completed Cochrane review assessed the effectiveness and cost-benefits of Alcoholics Anonymous (AA) and clinically delivered 12-Step Facilitation (TSF) interventions for alcohol use disorder (AUD). This paper summarizes key findings and discusses implications for practice and policy.

Methods: Cochrane review methods were followed. Read More

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http://dx.doi.org/10.1093/alcalc/agaa050DOI Listing

Nutritional Care of Patients Admitted to Hospital for Alcohol Withdrawal: A 5-Year Retrospective Audit.

Alcohol Alcohol 2020 Jul 6. Epub 2020 Jul 6.

Public Health Nutrition, School of Health and Society, University of Wollongong, 2500 New South Wales, Australia.

Aim: The aim of this study was to describe the characteristics and the nutritional approaches implemented with patients undergoing alcohol withdrawal.

Methods: A retrospective analysis of medical records for patients admitted to a tertiary hospital for alcohol withdrawal was completed over a 5-year period 2013-2017. Data on nutrition-related assessment and management were extracted and descriptively analysed. Read More

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http://dx.doi.org/10.1093/alcalc/agaa060DOI Listing

High-performance sub-wavelength grating-based resonator sensors with substrate overetch.

Opt Lett 2019 Dec;44(24):5981-5984

We propose a strategy to improve sensing performance of sub-wavelength-grating (SWG) waveguide-based sensors by introducing a substrate-overetch (SOE) geometry. The proposed SOE-SWG waveguide shows enhanced analyte interaction and a reduced group index, which improves the sensitivity of resonator-based sensors. The overetch process was realized in // plasma for 40 sec with a / selectivity of 10:1, obtaining a 285-nm anisotropic overetch in the layer. Read More

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http://dx.doi.org/10.1364/OL.44.005981DOI Listing
December 2019

and variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients.

Tumour Biol 2020 Jul;42(7):1010428320938494

Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.

Radiotherapy and cisplatin lead to cell killing in head and neck squamous cell carcinoma patients, but adverse events and response to treatment are not the same in patients with similar clinicopathological aspects. The aim of this prospective study was to evaluate the roles of c.215G > C, c. Read More

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http://dx.doi.org/10.1177/1010428320938494DOI Listing

An in vitro assessment of antiviral activity for ethanol extract of Desmodium canadense against bovine herpesvirus type 1.

Pol J Vet Sci 2020 Jun;23(2):177-184

Department of Veterinary Pathobiology, Veterinary Faculty, Lithuanian University of Health Sciences, Tilzes 18, 47181, Kaunas, Lithuania.

Herpesviruses (HV) are pathogens causing infections in humans and animals worldwide. Since it shares many common features with other HV, bovine HV type 1 (BoHV-1) was selected as a model to test the anti-herpesviral activity of medicinal plants.Fifteen plants were chosen in this study for their medical, antibacterial and antiviral proper-ties. Read More

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http://dx.doi.org/10.24425/pjvs.2020.132763DOI Listing

Associations of a Panel of Adipokines with Fat Deposits and Metabolic Phenotypes in a General Population.

Obesity (Silver Spring) 2020 Jul 6. Epub 2020 Jul 6.

Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.

Objective: This study provides a comprehensive overview of the associations of five adipokines (adiponectin, chemerin, galectin-3, leptin, and resistin) with fat deposits, behavioral risk factors, and metabolic phenotypes.

Methods: Using multivariable linear and logistic regression models, cross-sectional data from 4,116 participants of the population-based Study of Health in Pomerania were analyzed.

Results: Participants with obesity showed higher chemerin, galectin-3, and leptin but showed lower adiponectin concentrations. Read More

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http://dx.doi.org/10.1002/oby.22871DOI Listing

Rapid Safety and Quality Control During Fish Shelf-Life by Using A Portable Device.

J Sci Food Agric 2020 Jul 6. Epub 2020 Jul 6.

Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, 6 20133, Milan, Italy.

Background: Fish consumption is increasing nowadays both because of its positive role for health due to the abundant presence of unsaturated fatty acids and for its use in many new food preparations (e.g. raw fillet used for uncooked sushi and sashimi dishes). Read More

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http://dx.doi.org/10.1002/jsfa.10646DOI Listing

Kinetics of active water/ethanol Janus droplets.

Soft Matter 2020 Jul 6. Epub 2020 Jul 6.

Experimental Physics, Saarland University, 66123 Saarbrücken, Germany.

Droplets made of a water/ethanol mixture spontaneously self-propel in an oil/surfactant solution and, depending on the initial ethanol concentration at the time of production, may evolve in up to three stages. Upon self-propulsion the droplets absorb surfactant molecules during their continuous motion in the oily phase. In combination with the continuous loss of ethanol this mass exchange with the ambient phase may lead to a spontaneous phase separation of the water/ethanol mixture, and eventually to the formation of characteristic Janus droplets. Read More

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http://dx.doi.org/10.1039/d0sm00460jDOI Listing

Technological development of mucoadhesive film containing poloxamer 407, polyvinyl alcohol and polyvinylpyrrolidone for buccal metronidazole delivery.

Ther Deliv 2020 Jul 5. Epub 2020 Jul 5.

Laboratory of Research & Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Avenida Colombo, nº 5790, 87020-900, Maringa, Brazil.

This work aimed to develop a mucoadhesive film composed of a triblock copolymer (poloxamer 407), polyvinyl alcohol and polyvinylpyrrolidone for buccal modified delivery of metronidazole. Three film formulations containing different polymer amounts were prepared by solvent casting. They were characterized as physicochemical, mechanical and mucoadhesive properties, and metronidazole release profiles. Read More

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http://dx.doi.org/10.4155/tde-2020-0031DOI Listing

[Studies on chemical constituents of stems of Herpetospermum pedunculosum].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(11):2571-2577

College of Pharmaceutical Sciences, Southwest University Chongqing 400715, China.

This project is to study chemical compositions from the stems of Herpetospermum pedunculosum. Twenty-two compounds were isolated from the 70% acetone extract of the stems of H. pedunculosum by column chromatography on Sephadex LH-20, semi-preparative HPLC and preparative TLC. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200227.201DOI Listing

[Thermosensitive gel of polysaccharide from Ganoderma applanatum combined with paclitaxel for mice with 4T1 breast cancer].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(11):2533-2539

College of Pharmacy,Zhejiang University of Technology Hangzhou 310014,China.

Polysaccharide from Ganoderma applanatum has the activities of anti-tumor and enhancing immune function. There were no reports on antitumor effect of its intratumoral injection. In this study, the polysaccharide was extracted from G. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200328.304DOI Listing

[Chemical constituents from Xanthii Fructus].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(12):2907-2915

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research,Institute of Traditional Chinese Medicine and Natural Product, College of Pharmacy, Jinan University Guangzhou 510632, China.

This study was carried out to investigate the chemical constituents from Xanthii Fructus(the fruits of Xanthium sibiricum). The compounds were separated and purified by silica gel column chromatography, Sephadex LH-20 and ODS chromatography and semi-preparative HPLC. Base on HR-ESI-MS, NMR and other spectral data, their structures were identified. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200228.201DOI Listing

Elevated Alanine Aminotransferase in Early Pregnancy and Subsequent Development of Gestational Diabetes and Preeclampsia.

J Korean Med Sci 2020 Jul 6;35(26):e198. Epub 2020 Jul 6.

Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea.

Background: Nonalcoholic fatty liver disease (NAFLD) is now considered as a hepatic manifestation of metabolic syndrome and elevated alanine aminotransferase (ALT) is commonly related to NAFLD in the absence of viral hepatitis or alcohol abuse. Previous studies have indicated that elevated ALT is associated with diabetes or metabolic syndrome in adults, but the clinical significance of ALT or NAFLD in pregnancy has not been well determined. The objective of this study was to determine the association between elevated ALT in early pregnancy and the development of gestational diabetes or preeclampsia in late pregnancy. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e198DOI Listing

The severity of symptoms is insufficient to predict major alterations to quality of life of patients with fecal incontinence or chronic constipation.

Int J Colorectal Dis 2020 Jul 5. Epub 2020 Jul 5.

Digestive Center, University Hospital of Nice, 151 route de Saint Antoine de Ginestière - CS 23079, 06202, Nice Cedex, France.

Purpose: Evaluate the impact of fecal incontinence (FI) and chronic constipation (CC) on the quality of life (QoL) in a large population and determine if a threshold of symptom scores was associated with alterations to QoL.

Methods: A total of 422 outpatients with FI (n = 186), CC (n = 186), and mixed FI-CC (n = 50) referred for anorectal manometry were included prospectively. All patients completed a set of questionnaires to evaluate the severity of FI and CC (respectively Jorge and Wexner and KESS scores) and their impact on QoL (Gastrointestinal Quality of Life Index (GIQLI)). Read More

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http://dx.doi.org/10.1007/s00384-020-03685-wDOI Listing

Valorization of apple pomace using bio-based technology for the production of xylitol and 2G ethanol.

Bioprocess Biosyst Eng 2020 Jul 5. Epub 2020 Jul 5.

Lorena Engineering School, University of São Paulo, Estrada Municipal Do Campinho S/N, Lorena, São Paulo, CEP 12602-810, Brazil.

Apple pomace was studied as a raw material for the production of xylitol and 2G ethanol, since this agroindustrial residue has a high concentration of carbohydrate macromolecules, but is still poorly studied for the production of fermentation bioproducts, such as polyols. The dry biomass was subjected to dilute-acid hydrolysis with HSO to obtain the hemicellulosic hydrolysate, which was concentrated, detoxified and fermented. The hydrolyzate after characterization was submitted to submerged fermentations, which were carried out in Erlenmeyer flasks using, separately, the yeasts Candida guilliermondii and Kluyveromyces marxianus. Read More

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http://dx.doi.org/10.1007/s00449-020-02401-wDOI Listing

Social contacts, friends and satisfaction with friendships in patients with psychotic, mood and neurotic disorders 1 year after hospitalisation: data from five European countries.

Soc Psychiatry Psychiatr Epidemiol 2020 Jul 5. Epub 2020 Jul 5.

Unit for Social and Community Psychiatry (World Health Organisation Collaborating Centre for Mental Health Services Development), Queen Mary University of London, London, UK.

Background: People with severe mental illness often struggle with social relationships, but differences among diagnostic groups are unclear. We assessed and compared objective and subjective social relationship indicators among patients with psychotic, mood and neurotic disorders one year after hospitalisation in five European countries (Belgium, Germany, Italy, Poland and United Kingdom).

Methods: The number of social contacts, including family members and friends during the previous week (Social Network Schedule), and satisfaction with the number and quality of friendships (Manchester Short Assessment of Quality of Life Quality) were assessed by face-to-face interview. Read More

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http://dx.doi.org/10.1007/s00127-020-01915-8DOI Listing

Classical blood biomarkers identify patients with higher risk for relapse 6 months after alcohol withdrawal treatment.

Eur Arch Psychiatry Clin Neurosci 2020 Jul 5. Epub 2020 Jul 5.

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstrasse 7, 80336, Munich, Germany.

This naturalistic study among patients with alcohol dependence examined whether routine blood biomarkers could help to identify patients with high risk for relapse after withdrawal treatment. In a longitudinal study with 6-month follow-up among 133 patients with alcohol dependence who received inpatient alcohol withdrawal treatment, we investigated the usefulness of routine blood biomarkers and clinical and sociodemographic factors for potential outcome prediction and risk stratification. Baseline routine blood biomarkers (gamma-glutamyl transferase [GGT], alanine aminotransferase [ALT/GPT], aspartate aminotransferase [AST/GOT], mean cell volume of erythrocytes [MCV]), and clinical and sociodemographic characteristics were recorded at admission. Read More

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http://dx.doi.org/10.1007/s00406-020-01153-8DOI Listing

Identification of 40S ribosomal protein S8 as a novel biomarker for alcohol‑associated hepatocellular carcinoma using weighted gene co‑expression network analysis.

Oncol Rep 2020 Aug 5;44(2):611-627. Epub 2020 Jun 5.

Department of Liver‑Biliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550009, P.R. China.

Alcohol‑associated hepatocellular carcinoma (HCC) is a subtype of HCC with poor prognosis. The present study aimed to identify key biomarkers for alcohol‑associated HCC. The gene data profiles and corresponding clinical traits of patients with alcohol‑associated HCC were downloaded from The Cancer Genome Atlas (TCGA) database. Read More

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http://dx.doi.org/10.3892/or.2020.7634DOI Listing

IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model.

Int J Mol Med 2020 Aug 4;46(2):880-888. Epub 2020 Jun 4.

Graduate School, China Medical University, Shenyang, Liaoning 110001, P.R. China.

Interleukin (IL)‑18, a pro‑inflammatory cytokine, plays an important role in a number of skin diseases. The aim of the present study was to investigate the role of IL‑18 in the development of atopic dermatitis (AD). For this purpose, mice were divided into 4 groups (n=5/group) as follows: i) The wild‑type (WT) controls; ii) IL18 knockout (KO) controls; iii) MC903‑treated WT mice; and iv) MC903‑treated KO mice. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4630DOI Listing

Histology of Liver of the Deceased Due to Harmful Use of Alcohol.

Alcohol Alcohol 2020 Jul 6. Epub 2020 Jul 6.

Department of Forensic Medicine, Wroclaw Medical University, J. Mikulicza-Radeckiego 4 Str., 50-345 Wrocław, Poland.

Aim: To study types and incidence of histological changes in liver of people deceased due to harmful use of alcohol.

Methods: A retrospective review of medico-legal autopsy of 236 adults who died in the years 2015-2016 due to harmful use of alcohol was done. Histopathological liver samples taken during autopsies were evaluated. Read More

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http://dx.doi.org/10.1093/alcalc/agaa059DOI Listing

A Survey on HIV/AIDS-Related Knowledge, Attitudes, Risk Behaviors, and Characteristics of Men Who Have Sex with Men among University Students in Guangxi, China.

Biomed Res Int 2020 14;2020:7857231. Epub 2020 Jun 14.

Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.

In recent years, the prevalence of human immunodeficiency virus (HIV) infection among Chinese university students has increased significantly, and HIV transmission among men who have sex with men (MSM) comprises more than half of the new cases. There is still a lack of research investigating the incidence of male-to-male sex, the attitudes towards MSM, and the awareness of HIV/AIDS among university students in Guangxi, one of the HIV high-risk areas in China. Therefore, we performed a cross-sectional investigation among 578 male students, recruited by stratified sampling, in universities in Nanning, Guangxi, between January 2016 and March 2017. Read More

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http://dx.doi.org/10.1155/2020/7857231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312710PMC

Transesophageal Echocardiography-Guided WATCHMAN Implantation Without Contrast Use: A Three-Year, Single-Center Experience.

Cureus 2020 May 31;12(5):e8375. Epub 2020 May 31.

Cardiology, Capital Cardiology Associates, Albany Medical Center, Albany, USA.

Background It is unclear if the WATCHMAN device (Boston Scientific, St. Paul, Minnesota) can be implanted without contrast to prevent complications in patients with advanced chronic kidney disease (CKD) or contrast allergy. Objective The efficiency and safety of WATCHMAN implantation under transesophageal echocardiography (TEE)-guidance and fluoroscopy without contrast use. Read More

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http://dx.doi.org/10.7759/cureus.8375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328691PMC

Chronic Periodontal Disease increases risk for Prostate Cancer in Elderly individuals in South Korea: a Retrospective Nationwide Population-based Cohort Study.

J Cancer 2020 25;11(16):4716-4723. Epub 2020 May 25.

Department of Periodontology, Daejeon Dental Hospital, Institute of Wonkwang Dental Research, Wonkwang University College of Dentistry, Daejeon, Korea.

The association between prostate cancer (PC) and chronic periodontal disease (PD) has been evaluated in previous studies, but results have been inconsistent. This study aimed to determine whether the presence of chronic PD in old age increases the risk of PC using data in the large-scale elderly cohort. This nationwide population-based cohort study examined data of 121,240 South Korean individuals aged ≥ 60 years from the National Health Insurance Service-Elderly Cohort database who completed a national program between 2002 and 2015. Read More

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http://dx.doi.org/10.7150/jca.45369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330688PMC
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