3,955 results match your criteria Alcohol And Alcoholism[Journal]


Use of Nalmefene in Routine Practice: Results from a French Prospective Cohort Study and a National Database Analysis.

Alcohol Alcohol 2021 May 10. Epub 2021 May 10.

Université de Bordeaux, INSERM CIC-P 1401, Bordeaux PharmacoEpi, Rue Eugène Jacquet, Bordeaux 33000, France.

Aims: Two complementary studies were used to assess the real-life use of nalmefene in alcohol-dependent patients and its impact on alcohol use health status.

Methods: USE-PACT was a prospective cohort study designed to evaluate the real-life effectiveness of nalmefene in the management of alcohol dependence, as assessed by total alcohol consumption (TAC) and number of heavy drinking days (HDD) at 1 year. USE-AM was a cohort study using data from the French nationwide claims database and was used to evaluate the external validity of the population in the prospective study. Read More

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Using Machine Learning to Identify and Investigate Moderators of Alcohol Use Intervention Effects in Meta-Analyses.

Alcohol Alcohol 2021 May 10. Epub 2021 May 10.

Department of Counseling Psychology and Human Services, University of Oregon, 5251 University of Oregon, Eugene, OR 97403, USA.

Aims: To illustrate a machine learning-based approach for identifying and investigating moderators of alcohol use intervention effects in aggregate-data meta-analysis.

Methods: We illustrated the machine learning technique of random forest modeling using data from an ongoing meta-analysis of brief substance use interventions implemented in general healthcare settings. A subset of 40 trials testing brief alcohol interventions (BAIs) was used; these trials provided 344 estimates of post-intervention effects on participants' alcohol use as well as data on 20 potential moderators of intervention effects. Read More

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Corrigendum to: Alcohol Hangover Across the Lifespan: Impact Of Sex and Age.

Alcohol Alcohol 2021 May 7. Epub 2021 May 7.

Division of Psychology and Social Work, School of Education and Social Sciences, University of the West of Scotland, Paisley PA1 2BE, UK.

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Sex Differences in Acute Alcohol Sensitivity of Naïve and Alcohol Dependent Central Amygdala GABA Synapses.

Alcohol Alcohol 2021 Apr 29. Epub 2021 Apr 29.

The Scripps Research Institute, Department of Molecular Medicine, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA.

Aims: Alcohol use disorder (AUD) is linked to hyperactivity of brain stress systems, leading to withdrawal states which drive relapse. AUD differs among the sexes, as men are more likely to have AUD than women, but women progress from casual use to binge and heavy alcohol use more quickly and are more likely to relapse into repetitive episodes of heavy drinking. In alcohol dependence animal models of AUD, the central amygdala (CeA) functions as a hub of stress and anxiety processing and gamma-Aminobutyric acid (GABA)ergic signaling within the CeA is involved in dependence-induced increases in alcohol consumption. Read More

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Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants.

Authors:
David Curtis

Alcohol Alcohol 2021 Apr 24. Epub 2021 Apr 24.

UCL Genetics Institute, UCL, Darwin Building, Gower Street, London WC1E 6BT, UK.

Aims: The study aimed to identify specific genes and functional genetic variants affecting susceptibility to two alcohol-related phenotypes: heavy drinking and problem drinking.

Methods: Phenotypic and exome sequence data were downloaded from the UK Biobank. Reported drinks in the last 24 hours were used to define heavy drinking, while responses to a mental health questionnaire defined problem drinking. Read More

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Female C57BL/6J Mice Show Alcohol-Seeking Behaviour after Withdrawal from Prolonged Alcohol Consumption in the Social Environment.

Alcohol Alcohol 2021 Apr 24. Epub 2021 Apr 24.

Institute of Biotechnology, HiLIFE, University of Helsinki, PO Box 56, Viikinkaari 5, 00014, Helsinki, Finland.

Aims: Recently we developed a model to study alcohol-seeking behaviour after withdrawal in a social context in female mice. The model raised several questions that we were eager to address to improve methodology.

Methods: In our model, female mice were group-housed in automated cages with three conditioned (CS+) corners and water in both sides of one separate non-conditioned corner. Read More

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Linking Big Five Personality Domains and Facets to Alcohol (Mis)Use: A Systematic Review and Meta-Analysis.

Alcohol Alcohol 2021 Apr 24. Epub 2021 Apr 24.

School of Public Health and College of Education and Human Development, Georgia State University, Atlanta, GA 30303, USA.

Aims: The goal of this investigation was to synthesize (un)published studies linking Big Five personality domains and facets to a range of alcohol use outcomes. Meta-analyses were conducted to quantify the unique associations between alcohol use outcomes and each Big Five personality domains over and above other domains. Within each domain, meta-analyses also were conducted to examine the unique contribution of each personality facet in predicting alcohol use outcomes. Read More

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Underage Adolescents' Reactions to Adverts for Beer and Spirit Brands and Associations with Higher Risk Drinking and Susceptibility to Drink: A Cross-Sectional Study in the UK.

Alcohol Alcohol 2021 Apr 23. Epub 2021 Apr 23.

Cancer Policy Research Centre, Cancer Research UK, 2 Redman Place, London E20 1JQ, UK.

Aims: In the UK, adolescents under the minimum legal purchasing age (<18 years) are aware of a variety of alcohol marketing activities. It is therefore important to examine how such marketing appeals and how it might shape consumption. This study assessed the relationships between positive reactions to alcohol adverts and susceptibility to drink among never drinkers and higher-risk drinking among current drinkers. Read More

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Sport-Related and Psychosocial Factors Associated With Motives and Consequences Of Alcohol and Cannabis Use Among NCAA Athletes: A Systematic Review.

Alcohol Alcohol 2021 Apr 10. Epub 2021 Apr 10.

Department of Psychology, Harpur College of Arts & Sciences, Binghamton University, Binghamton, NY 13902, USA.

Aims: To review differences in alcohol- and cannabis-related motives and consequences among National Collegiate Athletic Association (NCAA) athletes as a function of athlete characteristics (e.g. gender and competition season status). Read More

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Limited Evidence of Associations Between Executive Functioning and Alcohol Involvement In UK Adolescents.

Alcohol Alcohol 2021 Apr 9. Epub 2021 Apr 9.

Department of Psychology, Institute of Population Health, Eleanor Rathbone Building, Bedford Street South, University of Liverpool, L69 7ZA, UK.

Aims: Deficits in motor inhibitory control and working memory have been hypothesized to be both a cause and consequence of heavy alcohol use. Adolescence is a critical developmental stage for inhibitory control and working memory, and it is also a stage when individuals are most likely to initiate alcohol use. This study aimed to examine whether inhibitory control and working memory would predict alcohol use and involvement in a group of UK adolescents. Read More

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Understanding the Broader Impacts Of Alcohol Marketing: Time For a Research Agenda Which Includes Adults.

Alcohol Alcohol 2021 Apr 9. Epub 2021 Apr 9.

Institute for Social Marketing and Health, Faculty of Health Sciences and Sport, University of Stirling, Stirling, FK9 4LA, Scotland.

Most research on alcohol marketing involves young people. Consequently, gaps remain in our understanding of how alcohol marketing reaches, engages and influences adults, who are the legitimate and primary targets for marketing communications. Responding to these lacunae in knowledge is necessary to help inform and evaluate population-level controls on alcohol marketing. Read More

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Reply to Smith et al. Regarding 'Does Advice Based on Biomarkers of Liver Injury or Non-Invasive Tests of Liver Fibrosis Impact High-Risk Drinking Behaviour: A Systematic Review with Meta-Analysis'.

Alcohol Alcohol 2021 Apr 5. Epub 2021 Apr 5.

Nottingham Digestive Diseases Biomedical Research Centre (NDDC), School of Medicine, University of Nottingham, Queens Medical Centre Nottingham, Nottingham NG7 2UH, UK.

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Affect-Based Problem Drinking Risk: The Reciprocal Relationship between Affective Lability and Problem Drinking.

Alcohol Alcohol 2021 Apr 5. Epub 2021 Apr 5.

University of Kentucky, Department of Psychology, 106B Kastle Hall, Lexington, KY 40506, USA.

Aims: Negative affect has been implicated in risk for the development of problematic drinking behavior. Furthermore, there is evidence for reciprocal relationships between negative affect and problem drinking, such that engagement in problem drinking also predicts increases in negative affect. However, affective models of risk often fail to consider affective lability-the experience of rapidly changing mood. Read More

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Alcohol Hangover Across the Lifespan: Impact Of Sex and Age.

Alcohol Alcohol 2021 Apr 5. Epub 2021 Apr 5.

Division of Psychology and Social Work, School of Education and Social Sciences, University of the West of Scotland, Paisley PA1 2BE, UK.

Aim: To investigate the relationship between age and hangover frequency and severity.

Method: An online survey, generated through Facebook, collected self-report data relating to alcohol consumption from 761 Dutch alcohol consumers aged 18-94 years (61.6% female). Read More

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Interventions to Improve Post-Detoxification Treatment Engagement and Alcohol Recovery: Systematic Review of Intervention Types and Effectiveness.

Alcohol Alcohol 2021 Apr 1. Epub 2021 Apr 1.

VA Palo Alto Health Care System, 3801 Miranda AvenuePalo Alto, CA 94304, USA.

Aims: Most inpatient alcohol detoxification patients do not seek treatment post-discharge, which increases the risk of relapse and re-hospitalization. To date, there have been no efforts to synthesize the evidence supporting the broad range of available interventions for this critical transition. The current study is a systematic review and evaluation of interventions designed to promote treatment engagement and recovery following alcohol detoxification. Read More

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Cognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis.

Alcohol Alcohol 2021 Mar 29. Epub 2021 Mar 29.

Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA.

Aims: This meta-analysis reviewed 15 clinical trials (18 study sites/arms), examining the efficacy of an integrated cognitive-behavioral intervention (CBI) delivered to individuals with an alcohol or other drug use disorder and a co-occurring mental health disorder (AOD/MHD). Outcomes were alcohol or other drug use and mental health symptoms at post-treatment through follow-up.

Methods: The inverse-variance weighted effect size was calculated for each study and pooled under random effects assumptions. Read More

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A Longitudinal Mediation Model of Negative Emotionality, Coping Motives and Drinking Intensity Among Individuals Receiving Community Treatment for Alcohol Use Disorder.

Alcohol Alcohol 2021 Mar 29. Epub 2021 Mar 29.

Department of Psychology, University of New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA.

Aims: Negative emotionality is a key domain in frameworks measuring heterogeneity in alcohol use disorder (AUD), such as the Addictions Neuroclinical Assessment (ANA). Recent research has examined the construct validity of the ANA negative emotionality domain, but has not examined whether this domain demonstrates predictive validity for drinking outcomes. In this study, we examined the association between self-reported negative emotionality at baseline and drinking intensity 1 year following AUD treatment initiation. Read More

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Hepatic Histopathology Among Excessive Drinkers Without Advanced Liver Disease.

Alcohol Alcohol 2021 Mar 26. Epub 2021 Mar 26.

Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Aims: Alcohol-associated liver disease represents a spectrum of histopathological changes from steatosis to advanced fibrosis and cirrhosis. The major goals of this retrospective study were to characterize the histologic features in patients with excessive alcohol use who presented with an abnormal hepatic panel and/or abnormal radiographic imaging and did not meet the clinical diagnosis of alcoholic hepatitis or cirrhosis.

Methods: We performed a retrospective study to describe hepatic histology of 62 and 83 excessive drinkers with normal and abnormal serum aspartate transaminase, respectively. Read More

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Alcohol Reduction to Reduce Relapse in Acute Alcoholic Pancreatitis-Missed Opportunities.

Alcohol Alcohol 2021 Mar 26. Epub 2021 Mar 26.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Pb 9600, 2300 RC, Leiden, The Netherlands.

Aim: Resuming drinking is a main contributant to recurrence in alcoholic pancreatitis. We assessed current clinical practice in the Netherlands regarding alcohol in managing patients with a first episode of acute alcoholic pancreatitis.

Methods: A survey was distributed to 35 hospitals affiliated with the Dutch Pancreatitis Study Group. Read More

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Increases in Risky Drinking During the COVID-19 Pandemic Assessed via Longitudinal Cohort Design: Associations With Racial Tensions, Financial Distress, Psychological Distress and Virus-Related Fears.

Alcohol Alcohol 2021 Mar 26. Epub 2021 Mar 26.

Center for Public Policy & Health Division of Mental Health & Substance Use, Kent State University, Kent, OH 44240, USA.

Background: The COVID-19 pandemic has created disruptions to daily life resulting in wide-spread unemployment and psychological distress. Recent studies have reported high rates of alcohol use during this time; however, longitudinal data remain scarce and factors associated with increases in high-risk drinking observed over time are unknown.

Aims: The current study examined changes in high-risk drinking patterns across four 7-day observation periods, prior to and following a university wide campus closure. Read More

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Comment on 'Does Advice Based on Biomarkers of Liver Injury or Non-Invasive Tests of Liver Fibrosis Impact High-Risk Drinking Behaviour: A Systematic Review and Meta-Analysis'.

Alcohol Alcohol 2021 Mar 24. Epub 2021 Mar 24.

School of Primary Care, Population Science and Medical Education (PPM), Faculty of Medicine, University of Southampton, University Hospital Southampton, SO16 6YD, England, UK.

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Does the Fast Alcohol Screening Test Accurately Distinguish Between Harmful and Severely Dependent Tiers of Alcohol Misuse?

Alcohol Alcohol 2021 Mar 23. Epub 2021 Mar 23.

Addictions Research Group, School of Psychology & Therapeutic Studies, University of South Wales, Pontypridd CF37 1DL, UK.

Aims: Primary aim: to determine the efficacy of FAST (the Fast Alcohol Screening Test) for detecting harmful and dependent levels of alcohol use. Secondary aim: to compare the performance of the FAST to two short forms of the Alcohol Use Disorder Identification Test (AUDIT): the AUDIT-C and AUDIT-3.

Methods: Data from 3336 individuals in South Wales, compiled from full AUDIT datasets, were examined. Read More

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Drinking and Neighborhood Contexts of Alcohol's Harms from Others.

Alcohol Alcohol 2021 Mar 16. Epub 2021 Mar 16.

Alcohol Research Group, Public Health Institute, 6001 Shellmound Street, Suite 450, Emeryville, CA 94608-1010, USA.

Aims: Negative consequences of alcohol (or secondhand effects) extend beyond drinkers to affect other people, including both known others (friends, family members, spouses/partners) and strangers. Secondhand effects of alcohol manifest across various social environments, including the places where people drink and the neighborhoods where they live. These neighborhoods are characterized by different levels of alcohol availability and degrees of residential social cohesion. Read More

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The Effects of Placebo and Moderate Dose Alcohol on Attentional Bias, Inhibitory Control and Subjective Craving.

Alcohol Alcohol 2021 Mar 8. Epub 2021 Mar 8.

Department of Psychology, Edge Hill University, St Helens Road, Ormskirk L39 4QP, UK.

Aims: Previous research indicates that acute alcohol intoxication and placebo can inhibit people's control over consumption behaviour and heighten attentional bias (AB) towards alcohol-related stimuli and craving. We designed a study to disentangle anticipated from pharmacological effects of alcohol in order to gain a clearer view of their relative contributions to alcohol consumption.

Methods: In a within-participants design (moderate alcohol dose, placebo and control), and over a minimum 2-week period, participants completed a battery of questionnaires and cognitive tasks, followed by a bogus taste task to measure ad libitum consumption. Read More

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The Association between the Alcohol Biomarker Phosphatidylethanol (PEth) and Self-Reported Alcohol Consumption among Russian and Norwegian Medical Patients.

Alcohol Alcohol 2021 Mar 3. Epub 2021 Mar 3.

Department of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway.

Aims: Valid measures to identify harmful alcohol use are important. Alcohol Use Disorders Identification Test (AUDIT) is a validated questionnaire used to self-report harmful drinking in several cultures and settings. Phosphatidylethanol 16:0/18:1 (PEth) is a direct alcohol biomarker measuring alcohol consumption levels. Read More

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Response to Letter by Benson et al. on 'Hangover and the Effects of L-Cysteine'.

Alcohol Alcohol 2021 Feb 25. Epub 2021 Feb 25.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1 C, 70211 Kuopio, Finland.

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February 2021

Leave the Past Behind by Recognizing the Effectiveness and Cost-Effectiveness of 12-Step Facilitation and Alcoholics Anonymous.

Alcohol Alcohol 2021 Feb 22. Epub 2021 Feb 22.

Department of Psychiatry, Massachusetts General Hospital Recovery Research Institute. 151 Merrimac Street, 6th Floor, Boston, MA 02114, USA.

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February 2021

Systematic Review and Dose-Response Meta-Analysis on the Relationship Between Alcohol Consumption and Sickness Absence.

Alcohol Alcohol 2021 Feb 19. Epub 2021 Feb 19.

Centre for Alcohol Policy Research (CAPR), La Trobe University, Melbourne, VIC 3086, Australia.

Aims: Alcohol consumption (AC) may cause workplace absence, but the findings of individual studies vary markedly. To date, no dose-response meta-analysis (DRMA) of the relationship between AC and sickness absence (SA) has been completed. This paper aims to estimate the dose-response relationship between AC and the risk of SA based on published observational studies. Read More

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February 2021

Alcohol Consumption, HDL-Cholesterol and Incidence of Colon and Rectal Cancer: A Prospective Cohort Study Including 250,010 Participants.

Alcohol Alcohol 2021 Feb 19. Epub 2021 Feb 19.

Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine, University of Oslo, Pb 1171 Blinderen, 0318 Oslo, Norway.

Aims: Alcohol consumption has been linked to colorectal cancer (CRC) and also to the high-density lipoprotein cholesterol level (HDL-C). HDL-C has been associated with the incidence of CRC. The aim of this study was to investigate the association between self-reported alcohol consumption, HDL-C and incidence of CRC, separately for the two sites. Read More

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February 2021