2,902 results match your criteria Alcohol [Journal]


Impact of moderate prenatal alcohol exposure on histaminergic neurons, histidine decarboxylase levels and histamine H receptors in adult rat offspring.

Alcohol 2018 Jul 22;76:47-57. Epub 2018 Jul 22.

Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States. Electronic address:

We have reported that moderate prenatal alcohol exposure (PAE) elevates histamine H receptor-mediated inhibition of glutamatergic neurotransmission in dentate gyrus (DG), and that the H receptor antagonist ABT-239 ameliorates PAE-induced deficits in DG long-term potentiation. Here, we investigated whether PAE alters other markers of histaminergic neurotransmission. Long-Evans rat dams voluntarily consumed either a 0% or a 5% ethanol solution 4 h each day throughout gestation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.007DOI Listing

Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats.

Alcohol 2018 Jul 17;76:37-45. Epub 2018 Jul 17.

Department of Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.

Alcohol produces complex effects on the immune system. Moderate alcohol use (1-2 drinks per day) has been shown to produce anti-inflammatory responses in human blood monocytes, whereas, the post mortem brains of severe alcoholics show increased immune gene expression and activated microglial markers. The present study was conducted to evaluate the time course of alcohol effects during exposure and after withdrawal, and to determine the relationship between microglial and cytokine responses in brain and blood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.005DOI Listing

The longitudinal effects of military spouses' concern and behaviors over partner drinking on relationship functioning.

Alcohol 2018 Jul 17;76:29-36. Epub 2018 Jul 17.

RAND Corporation, Santa Monica, CA, United States.

Among those in close relationships, the perception that one's partner has a drinking problem is more strongly related to detriments in relationship quality than are the actual rates of the partner's drinking. The current study extends this work by examining the effects of this perception on relationship functioning longitudinally and whether this association is mediated by changes in how one behaves in response to their partner's drinking. Spouses and partners of military service members who were concerned about their partner's drinking (n = 234) completed a baseline survey and a follow-up assessment five months later. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.004DOI Listing
July 2018
1 Read

Neurodevelopmental outcomes in individuals with fetal alcohol spectrum disorder (FASD) with and without exposure to neglect: Clinical cohort data from a national FASD diagnostic clinic.

Alcohol 2018 Jun 12;76:23-28. Epub 2018 Jun 12.

School of Health and Society, University of Salford, Salford, England, United Kingdom.

Disentangling the relative developmental impact of prenatal alcohol exposure from postnatal neglect is clinically valuable for informing future service provision. In this study, developmental outcomes across groups are compared in a 'natural experiment'.

Methods: Clinical data from 99 persons with fetal alcohol spectrum disorder (FASD) diagnoses were audited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.06.002DOI Listing

Minocycline Attenuates Ethanol-induced Cell Death and Microglial Activation in the Developing Spinal Cord.

Alcohol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Lexington VA Health Care System, Research & Development, 1101 Veterans Drive, Lexington, Kentucky 40502, USA. Electronic address:

Developmental exposure to ethanol may cause fetal alcohol spectrum disorders (FASD), and immature central nervous system (CNS) is particularly vulnerable to ethanol. In addition to the developing brain, we previously showed that ethanol also caused neuroapoptosis, microglial activation, and neuroinflammation in the spinal cord. Minocycline is an antibiotic that inhibits microglial activation and alleviates neuroinflammation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183020
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.12.002DOI Listing
December 2018
1 Read

Sexually divergent changes in select brain proteins and neurosteroid levels after a history of ethanol drinking and intermittent PTSD-like stress exposure in adult C57BL/6J mice.

Alcohol 2018 Dec 6. Epub 2018 Dec 6.

Department of Behavioral Neuroscience, Oregon Health & Sciences University, Portland, OR; VA Portland Health Care System, Portland, OR. Electronic address:

Human studies reported that the number of past-year stressors was positively related to current drinking patterns, including binge drinking. In animal models, exposure to predator odor stress (PS), considered a model of traumatic stress, consistently increased ethanol intake. Recently, we reported that repeated PS significantly increased ethanol intake and had a synergistic interaction with prior binge drinking (binge group) in male but not in female C57BL/6J mice, when compared to mice without prior binge exposure (control group). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183025
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.12.001DOI Listing
December 2018
1 Read

Cigarette smoking, alcohol consumption, and risk of colorectal cancer in South Korea: A case-control study.

Alcohol 2018 Jun 26;76:15-21. Epub 2018 Jun 26.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea. Electronic address:

The current case-control study comprehensively evaluated the status, quantity, and duration of smoking and alcohol drinking for both men and women, considering the subsites of colorectal cancer. A total of 925 colorectal cancer cases and 2775 controls were included in the analysis. Odds ratios (OR) and 95% confidence intervals (CI) were computed by logistic regression models adjusting for potential confounders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.06.004DOI Listing

Re-investigating the effects of chronic smoking on the pathology of alcohol-related human brain damage.

Alcohol 2018 Jul 11;76:11-14. Epub 2018 Jul 11.

Discipline of Pathology, Charles Perkins Centre, The University of Sydney School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

Both pathological and neuroimaging studies have shown that chronic alcohol abuse causes generalized white matter, but limited gray matter, volume loss. Recent neuroimaging studies suggest that tobacco smoking also causes brain atrophy in both alcoholics and neurologically normal individuals. However, a recent pathological study, employing a manual technique to determine regional volumes, found no significant effects of smoking on either global or selected regional gray matter volumes in smokers or smoking alcoholics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.001DOI Listing
July 2018
1 Read

Associations between gastrointestinal humoral factors and pancreatic proteolytic enzymes in alcohol-related versus non-alcohol-related pancreatitis.

Alcohol 2018 Jun 28;76:1-10. Epub 2018 Jun 28.

School of Medicine, University of Auckland, Auckland, New Zealand. Electronic address:

Background: Alcohol-related pancreatitis is common and the gastrointestinal tract plays an important role in the regulation of pancreatic exocrine function. While the relationship between pancreatic proteolytic enzymes and insulin (as well as other pancreatic hormones) has been investigated in detail, little is known about the relationship between pancreatic proteolytic enzymes and gastrointestinal humoral factors. The aim of this study was to study the associations between trypsin, chymotrypsin, and a panel of gastrointestinal humoral factors in patients after an episode of alcohol-related versus non-alcohol-related pancreatitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.06.005DOI Listing
June 2018
1 Read

Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults.

Alcohol 2018 May 31;75:89-97. Epub 2018 May 31.

Department of Psychiatry, School of Medicine, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.

Our aim was to analyze metabolite profile changes in serum associated with moderate-to-heavy consumption of alcohol in young adults and to evaluate whether these changes are connected to reduced brain gray matter volumes. These study population consisted of young adults with a 10-year history of moderate-to-heavy alcohol consumption (n = 35) and light-drinking controls (n = 27). We used the targeted liquid chromatography mass spectrometry method to measure concentrations of metabolites in serum, and 3. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173098
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.010DOI Listing
May 2018
4 Reads

The α3β4 nicotinic acetylcholine receptor antagonist 18-Methoxycoronaridine decreases binge-like ethanol consumption in adult C57BL/6J mice.

Alcohol 2018 Nov 26. Epub 2018 Nov 26.

Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania, 16802, United States of America. Electronic address:

Binge alcohol drinking is a health burden in the United States which has an alarming economic impact. Unfortunately, medications available for alcohol abuse have low efficacy or adverse side effects creating a need to evaluate novel therapies. Growing research suggests that 18-Methoxycoronaridine (18-MC), an α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, may be effective at reducing ethanol consumption. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183026
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.11.006DOI Listing
November 2018
2 Reads

In Memoriam: Thomas R. Jerrells Editor Emeritus, Alcohol: An International Biomedical Journal.

Authors:
Todd A Wyatt

Alcohol 2018 Dec;73:89-90

College of Public Health at University of Nebraska Medical Center, Omaha, NE, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.08.002DOI Listing
December 2018

Assessment of Interleukin-6 Signaling Effects on Behavioral Changes Associated with Acute Alcohol Intoxication in adult male rats.

Alcohol 2018 Nov 22. Epub 2018 Nov 22.

Developmental Exposure to Alcohol Research Center (DEARC), Behavioral Neuroscience Program, Department of Psychology, Binghamton University-SUNY, Binghamton, NY, 13902-6000. Electronic address:

Recent studies have demonstrated unique brain cytokine signatures associated with acute ethanol intoxication (increased IL-6) and withdrawal (increased IL-1β and TNFα). The purpose of the present studies was to examine the potential functional role of increased central interleukin-6 (IL-6). We utilized two tests of ethanol sensitivity to establish a potential role for IL-6 after high (3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.11.004DOI Listing
November 2018
9 Reads

The impact of low to moderate chronic intermittent ethanol exposure on behavioral endpoints in aged, adult and adolescent rats.

Alcohol 2018 Nov 22. Epub 2018 Nov 22.

Department of Psychological Science, Ball State University.

The average age of the population in the United States and other countries is increasing. Understanding the health consequences in the aged population is critical. Elderly individuals consume ethanol, often at elevated rates, and in some cases in a binge episode. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.11.005DOI Listing
November 2018

Leveraging calcium imaging to illuminate circuit dysfunction in addiction.

Alcohol 2018 Jun 6. Epub 2018 Jun 6.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; The Salk Institute for Biological Sciences, 10010 N Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address:

Alcohol and drug use can dysregulate neural circuit function to produce a wide range of neuropsychiatric disorders, including addiction. To understand the neural circuit computations that mediate behavior, and how substances of abuse may transform them, we must first be able to observe the activity of circuits. While many techniques have been utilized to measure activity in specific brain regions, these regions are made up of heterogeneous sub-populations, and assessing activity from neuronal populations of interest has been an ongoing challenge. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183008
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.013DOI Listing
June 2018
4 Reads

Suppressing effect of CMPPE, a new positive allosteric modulator of the GABA receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats.

Alcohol 2018 May 31;75:79-87. Epub 2018 May 31.

Neuroscience Institute, Section of Cagliari, National Research Council of Italy, I-09042 Monserrato, CA, Italy. Electronic address:

Positive allosteric modulators (PAMs) of the GABA receptor constitute a class of pharmacological agents gaining increasing attention in the alcohol research field because of their ability to suppress several alcohol-related behaviors in rodents. CMPPE is a novel GABA PAM, still limitedly characterized in vivo. It was therefore of interest to test its ability to affect operant, oral self-administration of alcohol and cue-induced reinstatement of alcohol seeking in alcohol-preferring rats. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183008
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.015DOI Listing
May 2018
4 Reads

Effects of noncontingent ethanol, DHEA, and pregnanolone administration on ethanol self-administration in outbred female rats.

Alcohol 2018 May 9;75:67-77. Epub 2018 May 9.

Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States; Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States.

Previous research from this laboratory demonstrated that male outbred rats (Long-Evans) can be trained to prefer ethanol (10% v/v) over water during 30-min home-cage sessions and that higher ethanol concentrations (18-32% v/v) can serve as a reinforcer under various operant schedules. Further, we have shown that two neurosteroids, dehydroepiandrosterone (DHEA) and pregnanolone, can readily decrease ethanol self-administration in males. The present study used the same procedures in an attempt to systematically replicate the previous findings in female outbred rats. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173094
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.003DOI Listing
May 2018
3 Reads

Anti-addictive properties of COR659 - Additional pharmacological evidence and comparison with a series of novel analogues.

Alcohol 2018 May 17;75:55-66. Epub 2018 May 17.

Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100, Siena (SI), Italy.

A recent study found that COR659 (methyl 2-[(4-chlorophenyl)carboxamido]-4-ethyl-5-methylthiophene-3-carboxylate) reduced operant alcohol and chocolate self-administration in rats; COR659 also suppressed cue-induced reinstatement of chocolate seeking in rats. COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABA receptor and an action at the cannabinoid CB receptor. The present study investigated whether the reducing effect of COR659 on alcohol and chocolate self-administration was maintained after repeated treatment and if COR659 affected cue-induced reinstatement of alcohol seeking; additionally, it evaluated the ability of 9 structural analogues of COR659 - designed modifying the substituents on the phenylcarboxamido moiety and replacing the thiophene with the pyridine ring - to affect alcohol and chocolate self-administration. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183010
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.007DOI Listing
May 2018
3 Reads

Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung.

Alcohol 2018 Nov 13. Epub 2018 Nov 13.

Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY, 40292, USA; University of Louisville Alcohol Research Center, Louisville, KY, 40292. Electronic address:

Introduction: Alcohol use disorders are major risk factors for the development of and susceptibility to acute respiratory distress syndrome. Although these risks of alcohol consumption on the lung are well described, mechanisms by which alcohol abuse promotes acute lung injury are poorly understood. These gaps in our understanding are due, at least in part, to limitations of animal models to recapitulate human alcohol consumption. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183008
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.008DOI Listing
November 2018
9 Reads

The use of chemogenetic approaches in alcohol use disorder research and treatment.

Alcohol 2018 Jun 1. Epub 2018 Jun 1.

Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX 77807, United States. Electronic address:

Several novel techniques were developed recently to explore neural circuit mechanisms of neuropsychiatric disorders. These techniques include the Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools, which represent valuable platforms for selective and non-invasive control of neural activity with a high degree of spatial resolution. Among all variants, Gq- and Gi-DREADDs are widely used by neuroscientists to dissect out the circuitry and cellular signals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295360PMC
June 2018
3 Reads

Advances in behavioral animal models of alcohol use disorder.

Alcohol 2018 Jun 1. Epub 2018 Jun 1.

School of Psychological Sciences, Tel Aviv University, 69978 Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, 69978 Tel Aviv, Israel. Electronic address:

Alcohol use disorder (AUD) is a multifaceted neuropsychiatric disease that combines behavioral, psychosocial, and neurobiological aspects. Over the previous decade, animal models have advanced in modeling the major psychological constructs that characterize AUD. These advances pave the road for more sophisticated behavioral models that capture addiction-related aspects, such as alcohol craving, compulsive seeking and intake, dependence, and relapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.05.014DOI Listing
June 2018
1 Read

Repetitive transcranial magnetic stimulation: Re-wiring the alcoholic human brain.

Alcohol 2018 Jun 2. Epub 2018 Jun 2.

Alcohol Use Disorder Unit, Department of Internal Medicine, Gastroenterology and Hepatology, Catholic University of Rome, Italy.

Alcohol use disorders (AUDs) are one of the leading causes of mortality and morbidity worldwide. In spite of significant advances in understanding the neural underpinnings of AUDs, therapeutic options remain limited. Recent studies have highlighted the potential of repetitive transcranial magnetic stimulation (rTMS) as an innovative, safe, and cost-effective treatment for AUDs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.05.011DOI Listing

Alcohol and Cannabis Use Alter Pulmonary Innate Immunity.

Alcohol 2018 Nov 9. Epub 2018 Nov 9.

University of Colorado, Anschutz Medical Campus, Aurora, CO 80045.

Purpose: Cannabis use is increasing due to recent legislative changes. In addition, cannabis is often used in conjunction with alcohol. The airway epithelium is the first line of defense against infectious microbes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183017
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.11.002DOI Listing
November 2018
11 Reads

Lung allograft donors with excessive alcohol use have increased levels of human antimicrobial peptide LL-37.

Alcohol 2018 Nov 9. Epub 2018 Nov 9.

Alcohol Research Program, Stritch School of Medicine, Loyola University Chicago Health Sciences Campus, 2160 S. 1(st) Ave., Maywood, IL 60153, USA; Burn and Shock Trauma Research Institute, Stritch School of Medicine, Loyola University Health Sciences Campus, 2160 S. 1(st) Ave., Maywood, IL 60153, USA. Electronic address:

The relatively low long-term survival rate of lung transplants as compared to other organ recipients serves as an impetus to identify potential lung dysfunction as early as possible. There is an association between donor heavy alcohol use and acute lung injury in the lung allograft after transplant, known as primary graft dysfunction. Excessive alcohol use (EAU) can induce pulmonary immune dysregulation in response to an infection. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183020
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.11.003DOI Listing
November 2018
3 Reads

Early life stress and voluntary alcohol consumption in relation to Maoa methylation in male rats.

Alcohol 2018 Nov 8. Epub 2018 Nov 8.

Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Electronic address:

Early life stress (ELS) or alcohol consumption can influence DNA methylation and affect gene expression. The monoamine oxidase A (Maoa) encodes the enzyme that metabolizes monoaminergic neurotransmitters crucial for the stress response, alcohol reward, and reinforcement. Previously, we reported lower Maoa expression in the nucleus accumbens and dorsal striatum of male rats exposed to ELS during the first three postnatal weeks, and to voluntary alcohol consumption in adulthood, compared with controls. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183023
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.11.001DOI Listing
November 2018
4 Reads

Special issue on new technologies for alcohol research and treatment.

Alcohol 2018 Jun 14. Epub 2018 Jun 14.

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157 United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.06.003DOI Listing
June 2018
4 Reads

Ethanol→Nicotine & Nicotine →Ethanol Drug-Sequence Discriminations: Conditional Stimulus Control with Two Interoceptive Drug Elements in Rats.

Authors:
Joseph R Troisi

Alcohol 2018 Nov 5. Epub 2018 Nov 5.

Saint Anselm College, Manchester, NH, USA. Electronic address:

Self-administration of Ethanol (E) and nicotine (N) occurs frequently in tandem orders (i.e., N→E vs. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183014
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.012DOI Listing
November 2018
3 Reads

Methylphenidate and alcohol effects on flash-evoked potentials, body temperature, and behavior in Long-Evans rats.

Alcohol 2018 Oct 27. Epub 2018 Oct 27.

Department of Psychology, Lawrence University, 711 E. Boldt Way, Appleton, WI 54911 USA. Electronic address:

Methylphenidate (MPD) is a psychostimulant used to treat Attention Deficit Hyperactivity Disorder (ADHD). Most adult ADHD patients use ethanol in combination with MPD. This research examined the effects of MPD and ethanol on flash-evoked potentials (FEPs) recorded from the visual cortex (VC; a cortical response frequently used to assess neural activity and sensory processing) and superior colliculus (SC; a structure involved in attention and orientation) of chronically implanted male Long-Evans rats, and on body temperature and open field behavior. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183024
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.009DOI Listing
October 2018
3 Reads

Neonatal alcohol exposure augments voluntary ethanol intake in the absence of potentiated anxiety-like behavior induced by chronic intermittent ethanol vapor exposure.

Alcohol 2018 Oct 29. Epub 2018 Oct 29.

Research & Development Service, John D. Dingell VA Medical Center, 4646 John R St., Detroit, MI, USA, 48201; Department of Neurosurgery, Wayne State University School of Medicine, 4160 John R St., Detroit, MI, USA, 48201. Electronic address:

Individuals fetally exposed to alcohol have a disproportionate risk for developing lifetime alcohol dependence, an association that may be confounded by the presence of comorbid conditions, such as anxiety. Anxiety is also observed following fetal alcohol exposure and known to exacerbate ethanol consumption, highlighting the utility of animal models to assess this relationship. The present study evaluated the impact of third-trimester equivalent ethanol exposure on ethanol consumption and anxiety-like, marble burying behavior in adult, male C57BL/6 mice following exposure to chronic intermittent ethanol vapor, proposed to model dependence. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183019
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.011DOI Listing
October 2018
1 Read

Alcohol hangover effects on brain cortex non-synaptic mitochondria and synaptosomes bioenergetics.

Alcohol 2018 Oct 29. Epub 2018 Oct 29.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisicoquímica, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL) Buenos Aires, Argentina. Electronic address:

Alcohol hangover (AH) has been associated with oxidative stress and mitochondrial dysfunction. We herein postulate that AH-induced mitochondrial alterations can be due to a different pattern of response in synaptosomes and non-synaptic (NS) mitochondria. Mice received i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.10.010DOI Listing
October 2018

AWARE: A Wearable Awareness with Real-time Exposure, for monitoring alcohol consumption impact through Ethyl Glucuronide detection.

Alcohol 2018 Oct 23. Epub 2018 Oct 23.

Department of Bioengineering, University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA. Electronic address:

Here we demonstrate for the first time a dynamic monitoring of the ethanol metabolite Ethyl Glucuronide (EtG) for a more robust evaluation of alcohol consumption compared to conventional methods. A wearable biosensor device capable of reporting EtG levels in sweat both continuously via low power impedance spectroscopy is reported. The custom hardware was compared against conventional benchtop potentiostat, demonstrating comparable results in the application space of EtG detection in low volume sweat. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183007
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.006DOI Listing
October 2018
6 Reads
2.010 Impact Factor

Characterizing chronic pain and alcohol use trajectory among treatment-seeking alcoholics.

Alcohol 2018 May 25;75:47-54. Epub 2018 May 25.

Department of Psychiatry, University of Florida, PO Box 100256, Gainesville, FL 32610, United States.

Accumulating evidence indicates pain may be an important risk factor for development of alcohol use disorder (AUD) and risk of relapse for people recovering from AUD. This study was conducted to characterize the prevalence and severity of significant recurrent pain and various chronic pain conditions in treatment-seeking alcoholics. In addition, we sought to examine associations between alcohol use trajectory and pain presence/severity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183009
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.009DOI Listing
May 2018
6 Reads

Dysfunctional Preparatory Processes in Hazardous Drinkers: An ERP Study.

Alcohol 2018 Oct 21. Epub 2018 Oct 21.

Laboratory of Neuromotor Control and Learning, Shenzhen University, Shenzhen, China. Electronic address:

Alcohol drinking is associated with impaired cognitive and motor performance. This electrophysiological study examined the differences in the preparatory processes preceding motor imagery (visual and kinaesthetic) and execution between hazardous drinkers and non-hazardous drinking controls. Twenty-two hazardous drinkers and 22 non-hazardous drinking controls were recruited to participate in the study. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173102
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.005DOI Listing
October 2018
3 Reads
2.010 Impact Factor

Prenatal ethanol exposure potentiates isolation-induced ethanol consumption in young adult rats.

Alcohol 2018 Oct 17;75:39-46. Epub 2018 Oct 17.

Instituto de Investigación Médica M. y M. Ferreyra (INIMEC - CONICET-UNC), Córdoba, C.P 5000, Argentina. Electronic address:

Prenatal and/or early postnatal ethanol exposure (PEE) is associated with significant behavioral and physiological deficits in offspring, including alterations in stress response systems and a greater likelihood of alcohol use disorders. Stress-induced ethanol drinking after PEE, however, has been largely unexplored. The present study analyzed ethanol intake in male Sprague-Dawley rats after protracted prenatal and early postnatal ethanol exposure and tested whether social isolation during the sensitive period of adolescence modulates the effects of PEE on ethanol drinking. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183008
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.006DOI Listing
October 2018
4 Reads

PKA, PP1, and DC1 phosphorylation mediate alcohol-induced ciliary dysfunction in Chlamydomonas reinhardtii.

Alcohol 2018 May 9;75:31-38. Epub 2018 May 9.

University of Mississippi Medical Center, Department of Cell and Molecular Biology, 2500 North State St., Jackson, MS 39216, United States. Electronic address:

Excessive alcohol consumption impairs mucociliary clearance, in part, by compromising ciliary movement. Our previous study found alcohol reduces ciliary beat frequency in Chlamydomonas through a mechanism that involves the β and γ heavy chains of the outer dynein arm (ODA). Moreover, we identified DC1, a subunit of the ODA-docking complex (ODA-DC), as the first ciliary target for alcohol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226345PMC

Effects of ethanol on human periodontal ligament fibroblasts subjected to static compressive force.

Alcohol 2018 Oct 15. Epub 2018 Oct 15.

Department of Orthodontics, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. Electronic address:

Consumption of toxic substances like alcohol is widespread in the general population and thus also in patients receiving orthodontic treatment. Since human periodontal ligament (hPDL) fibroblasts play a key role in orthodontic tooth movement (OTM) by expressing cytokines and chemokines, we wanted to clarify, whether ethanol modulates the physiological activity and expression pattern of hPDL fibroblasts during static compressive force application. We pre-incubated hPDL fibroblasts for 24h with different ethanol concentrations, corresponding to casual (0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183012
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.004DOI Listing
October 2018
4 Reads

Adolescent intermittent ethanol exposure: Effects on pubertal development, novelty seeking, and social interaction in adulthood.

Alcohol 2018 May 9;75:19-29. Epub 2018 May 9.

Developmental Exposure Alcohol Research Center, Center for Development and Behavioral Neuroscience, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States.

Alcohol use initiated early in adolescence is a major predictor for the development of alcohol use disorders. This risk may be increased when drinking is initiated around the time of puberty, given evidence of bidirectional relationships between alcohol and gonadal hormones. The current study examined the effects of adolescent intermittent ethanol exposure (AIE) on pubertal timing and expression of novelty-seeking and peer-directed behaviors as well as neural correlates of these behaviors. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173100
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.002DOI Listing
May 2018
5 Reads

Age as a factor in stress and alcohol interactions: A critical role for the kappa opioid system.

Alcohol 2018 Nov 12;72:9-18. Epub 2017 Oct 12.

Binghamton University, Psychology Department, Developmental Exposure Alcohol Research Center, 400 Vestal Parkway, East Binghamton, New York 13902-6000, United States.

The endogenous kappa opioid system has primarily been shown to be involved with a state of dysphoria and aversion. Stress and exposure to drugs of abuse, particularly alcohol, can produce similar states of unease and anxiety, implicating the kappa opioid system as a target of stress and alcohol. Numerous behavioral studies have demonstrated reduced sensitivity to manipulations of the kappa opioid system in early life relative to adulthood, and recent reports have shown that the kappa opioid system is functionally different across ontogeny. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173087
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223135PMC
November 2018
5 Reads

Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes.

Alcohol 2018 Nov 8;72:75-88. Epub 2018 Jun 8.

Office of Science, Distilled Spirits Council of the United States, Washington, DC, United States.

It is well known that vulnerability to stress is a risk factor for alcohol use disorder (AUD). Chronic alcohol use can result in neuroadaptations in cortico-striatal pathways and hypothalamic pituitary adrenal (HPA) axis function that are manifested in altered behavioral and cognitive control functions contributing to alcohol craving, compulsive motivation, consumption, and consequences. This symposium brings together studies utilizing novel approaches to help improve our understanding of stress - past, acute, and chronic - on alcohol seeking and consumption and related outcomes using a combination of human laboratory models, neuroimaging, and clinical measures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.06.001DOI Listing
November 2018

Dysregulation of c-Jun N-terminal kinase phosphorylation in alcohol dependence.

Alcohol 2018 Apr 19;75:11-18. Epub 2018 Apr 19.

Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Alcohol & Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA. Electronic address:

Alcohol use disorder (AUD) is a chronic, relapsing psychiatric disease characterized by the emergence of negative emotional states and the development of motivational deficits that manifest during alcohol withdrawal. Accordingly, alcohol may be sought after and taken in excessive amounts to alleviate withdrawal-related symptoms. To develop more effective treatments for AUD, it is necessary to identify potential molecular targets that underlie the transition from initial alcohol use to alcohol dependence, and our previous work has implicated a role for potentiated glucocorticoid receptor (GR) signaling in this regard. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183000
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195479PMC
April 2018
5 Reads

Early gestational ethanol exposure in mice: Effects on brain structure, energy metabolism and adiposity in adult offspring.

Alcohol 2018 Apr 25;75:1-10. Epub 2018 Apr 25.

Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia. Electronic address:

We examined whether an early-life event - ethanol exposure in the initial stages of pregnancy - affected offspring brain structure, energy metabolism, and body composition in later life. Consumption of 10% (v/v) ethanol by inbred C57BL/6J female mice from 0.5 to 8. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183002
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.04.008DOI Listing
April 2018
4 Reads

Acute alcohol prevents the refeeding-induced decrease in autophagy but does not alter the increased protein synthetic response in heart.

Alcohol 2018 Dec 18;73:79-88. Epub 2018 Apr 18.

Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, United States. Electronic address:

Ethanol produces a state of anabolic resistance in skeletal muscle; however, whether the heart displays a similar defect is unknown. Hence, the purpose of this study was to determine the impact of acute ethanol administration on the major signal transduction pathways in the heart that are responsible for regulating the protein synthetic and degradative response to refeeding. Adult male C57Bl/6 mice were fasted for 12 h. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183007
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.04.005DOI Listing
December 2018
1 Read

Deletion of TLR-4 attenuates fetal alcohol exposure-induced gene expression and social interaction deficits.

Alcohol 2018 Dec 18;73:73-78. Epub 2018 Apr 18.

Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Fetal alcohol spectrum disorders (FASD) are associated with social interaction behavior and gastrointestinal (GI) abnormalities. These abnormal behaviors and GI abnormalities overlap with autism spectrum disorder (ASD). We investigated the effect of fetal alcohol exposure (FAE) on social interaction deficits (hallmark of autism) in mice. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173098
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193854PMC
December 2018
2 Reads

Use of alcohol biomarkers to identify alcohol misuse in organ donors.

Alcohol 2018 Dec 31;73:67-72. Epub 2018 Mar 31.

Alcohol Research Program, Loyola University Chicago Health Science Division, Maywood, IL, United States; Division of Pulmonary and Critical Care, Department of Medicine, Loyola University Medical Center, Maywood, IL, United States; Loyola University Chicago Stritch School of Medicine, Maywood, IL, United States.

Phosphatidylethanol is a direct alcohol biomarker for identifying alcohol misuse. It carries several advantages over other alcohol biomarkers, including a detection half-life of several weeks and little confounding by patient characteristics or organ dysfunction. The aim of this study is to derive an optimal phosphatidylethanol cut point to identify organ donors with alcohol misuse, and to assess the impact of alcohol misuse on organ allocation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173091
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188836PMC
December 2018
13 Reads

Daily Factors Driving Daily Substance Use and Chronic Pain among Older Adults with HIV: An Exploratory Study Using Ecological Momentary Assessment.

Alcohol 2018 Oct 8. Epub 2018 Oct 8.

Division of Geriatrics, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Background: Adults 50 and older make up approximately 50% of persons living with HIV. Multiple co-morbidities are common among this group, including chronic pain and substance abuse, yet little is known about the daily factors that either enhance or inhibit these experiences or behaviors. This study explored daily drivers of substance use, pain, and relief from pain among older adults living with HIV utilizing ecological momentary assessment (EMA). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183020
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.003DOI Listing
October 2018
2 Reads

Monitoring Alcohol Use in Heavy Drinking Soup Kitchen Attendees.

Alcohol 2018 Oct 8. Epub 2018 Oct 8.

Center for Alcohol and Addiction Studies, Brown University.

Rates of heavy alcohol use in soup kitchen attendees range from 30% to 38%, but these data are based entirely on self-reported drinking. Little is known about the intensity or frequency of drinking in this population. We assessed alcohol use transdermally every 30 minutes over a 3-week period among heavy drinkers who attended local soup kitchens. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183010
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.001DOI Listing
October 2018
4 Reads

Chronic inflammatory pain drives alcohol drinking in a sex-dependent manner for C57BL/6J mice.

Alcohol 2018 Oct 6. Epub 2018 Oct 6.

Pharmacology Curriculum, University of North Carolina, Chapel Hill, NC, 27599, United States; Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, United States; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, NC, 27599, United States; Neuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States. Electronic address:

Sex differences in chronic pain and alcohol abuse are not well understood. The development of rodent models is imperative for investigating the underlying changes behind these pathological states. In the present study, we investigated whether hind paw treatment with the inflammatory agent Complete Freund's Adjuvant (CFA) could generate hyperalgesia and alter alcohol consumption in male and female C57BL/6J mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.10.002DOI Listing
October 2018

Intermittent voluntary ethanol consumption combined with ethanol vapor exposure during adolescence increases drinking and alters other behaviors in adulthood in female and male rats.

Alcohol 2018 Dec 18;73:57-66. Epub 2018 Apr 18.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, United States. Electronic address:

Epidemiological studies suggest that binge drinking is prevalent among adolescents, and may result in neurobehavioral consequences. Animal models provide the experimental control to investigate the consequences of "binge" alcohol exposure during this neurodevelopmental epoch. The current study used an animal model that combined an intermittent pattern of alcohol vapor exposure with voluntary drinking of 20% unsweetened alcohol in adolescent male and female Wistar rats (postnatal day [PD] 22-62), in order to test for potential differences in behavioral changes, ethanol drinking, and hypocretin/orexin (Hcrt/OX) signaling associated with exposure status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193864PMC
December 2018

An association between MMP-9 and impaired T cell migration in ethanol-fed BALB/c mice infected with Respiratory Syncytial Virus-2A.

Alcohol 2018 Oct 3. Epub 2018 Oct 3.

University of Nebraska Medical Center, Pulmonary, Critical Care, Sleep & Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198-5910, USA; VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA; University of Nebraska Medical Center, Department of Environmental, Agricultural, & Occupational Health, Omaha, NE, 68198. Electronic address:

Matrix metalloproteinases are important for proper airway matrix structure and wound healing. These enzymes are also implicated in many airway diseases. Previously, chronic ethanol consumption was shown to prolong inflammation and delay viral clearance in respiratory syncytial virus (RSV)-infected mice. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183016
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.09.009DOI Listing
October 2018
1 Read

Loss of cAMP-dependent stimulation of isolated cilia motility by alcohol exposure is oxidant dependent.

Alcohol 2018 Oct 3. Epub 2018 Oct 3.

Pulmonary, Critical Care, Sleep, and Allergy Division, Department of Internal Medicine, USA. Electronic address:

Alcohol exposure is associated with decreased mucociliary clearance, a key innate defense essential to lung immunity. Previously we identified that prolonged alcohol exposure results in dysfunction of airway cilia that persists at the organelle level. This dysfunction is characterized by a loss of 3',5'-cyclic adenosine monophosphate (cAMP)-mediated cilia stimulation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183017
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.09.010DOI Listing
October 2018
9 Reads