Search our Database of Scientific Publications and Authors

I’m looking for a

    2810 results match your criteria Alcohol [Journal]

    1 OF 57

    High-intensity binge drinking is associated with alterations in spontaneous neural oscillations in young adults.
    Alcohol 2018 Jan 8;70:51-60. Epub 2018 Jan 8.
    Department of Psychology, College of Sciences, San Diego State University, San Diego, CA 92182-4611, United States; Department of Radiology, School of Medicine, University of California, San Diego, CA 92093-0841, United States. Electronic address:
    Heavy episodic alcohol consumption (also termed binge drinking) contributes to a wide range of health and cognitive deficits, but the associated brain-based indices are poorly understood. The current study used electroencephalography (EEG) to examine spontaneous neural oscillations in young adults as a function of quantity, frequency, and the pattern of their alcohol consumption. Sixty-one young adults (23. Read More

    Differential correlations between maternal hair levels of tobacco and alcohol with fetal growth restriction clinical subtypes.
    Alcohol 2018 Jan 4;70:43-49. Epub 2018 Jan 4.
    BC Natal Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Déu and Hospital Clínic, Passeig Sant Joan de Déu, 2, 08950 Esplugues de Llobregat, Barcelona, Spain; Maternal and Child Health and Development Network II (SAMID II), Instituto de Salud Carlos III (ISCIII), e Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (FEDER), Av. de Monforte de Lemos, 5, 28029 Madrid, Spain; Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Passeig Sant Joan de Déu, 2, 08950 Esplugues de Llobregat, Barcelona, Spain. Electronic address:
    Maternal exposure to tobacco and alcohol is a known cause, among others, for fetal growth restriction (FGR). Clinically, FGR can be subclassified into two forms: intrauterine growth restriction (IUGR) and small for gestational age (SGA), based on the severity of the growth retardation, and abnormal uterine artery Doppler or cerebro-placental ratio. This study aimed at investigating any differential correlation between maternal exposures to these toxins with the two clinical forms of FGR. Read More

    Predator-based psychosocial stress model of PTSD differentially influences voluntary ethanol consumption depending on methodology.
    Alcohol 2018 Jan 8;70:33-41. Epub 2018 Jan 8.
    Department of Psychology, Sociology & Criminal Justice, Ohio Northern University, 525 S. Main St., Ada, OH, 45810, USA.
    Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder typified by diagnostic symptom clusters including hyperarousal, avoidance, negative cognitions and mood, and intrusive re-experiencing of the traumatic event. Patients with PTSD have been reported to self-medicate with alcohol to ameliorate hyperarousal symptoms associated with the disorder. Research utilizing rodent models of PTSD to emulate this behavioral phenomenon has thus far yielded inconsistent results. Read More

    Socioeconomic status and alcohol use in low- and lower-middle income countries: A systematic review.
    Alcohol 2017 Dec 27;70:23-31. Epub 2017 Dec 27.
    WHO European Office for Prevention and Control of Noncommunicable Diseases (NCD Office), Moscow, Russian Federation. Electronic address:
    Background: Harmful use of alcohol is a major cause of global morbidity and mortality. The role of alcohol as a driver of the unfolding non-communicable disease crisis has led to high-profile calls for better epidemiological data. Despite causing a disproportionate amount of harm in low-income groups, there is a critical dearth of evidence on the intra-national socioeconomic patterning of alcohol use in low- and lower-middle income countries (LLMICs). Read More

    Chronic moderate alcohol drinking alters insulin release without affecting cognitive and emotion-like behaviors in rats.
    Alcohol 2017 Dec 16;70:11-22. Epub 2017 Dec 16.
    Neuroscience Program and Department of Psychology, University of Illinois at Urbana, Champaign, IL, United States. Electronic address:
    Because the consumption of alcoholic beverages prevails in society, its effects on diabetes risk is a subject of interest. Extant literature on this issue often disagrees. Here, we probed the effects of chronic moderate ethanol consumption on glucose metabolism in rats. Read More

    Alcohol affects the P3 component of an adaptive stop signal task ERP.
    Alcohol 2017 Aug 31;70:1-10. Epub 2017 Aug 31.
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States; R.L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, United States.
    Background: The P3 component of the event-related potential (ERP) has been particularly useful in alcohol research for identifying endophenotypes of alcohol-use disorder (AUD) risk in sober subjects. However, practice and/or fatigue reduce P3 amplitude, limiting the ability to ascertain acute and adaptive effects of alcohol exposure. Here, we report acute alcohol effects on P3 amplitude and latency using an adaptive stop signal task (aSST). Read More

    Both alcoholic and non-alcoholic steatohepatitis association with cardiovascular risk and liver fibrosis.
    Alcohol 2018 Jun 15;69:63-67. Epub 2017 Nov 15.
    Translational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico. Electronic address:
    Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. Mortality in NAFLD is mainly related to cardiovascular disease (CVD) and cancer. NAFLD and its association with both CVD and liver disease risk have been well evaluated, but the association of NAFLD with alcohol, known as "both alcoholic and non-alcoholic steatohepatitis" (BASH), remains uncertain. Read More

    Summary of the 2017 Alcohol and Immunology Research Interest Group (AIRIG) meeting.
    Alcohol 2018 Jun 31;69:51-56. Epub 2017 Oct 31.
    Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Immunology Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States. Electronic address:
    On June 24, 2017, the 22nd annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held as a satellite conference during the annual Research Society on Alcoholism (RSA) Scientific Meeting in Denver, Colorado. The 2017 meeting focused broadly on mechanisms that link alcohol to tissue injury and inflammation, and how this research can be translated to improve human health. Two plenary sessions composed the meeting, which first explored the association between alcohol and trauma/tissue injury, and finished with a discussion of alcohol and mucosal inflammation. Read More

    Enhanced erythrocyte antioxidant status following an 8-week aerobic exercise training program in heavy drinkers.
    Alcohol 2018 Jun 2;69:57-62. Epub 2017 Dec 2.
    Department of Physical Education and Sport Science, University of Thessaly, Karies, Trikala 42100, Greece; Institute of Human Performance and Rehabilitation, Centre for Research and Technology - Thessaly (CERETETH), Karies, Trikala 42100, Greece. Electronic address:
    Alcohol-induced oxidative stress is involved in the development and progression of various pathological conditions and diseases. On the other hand, exercise training has been shown to improve redox status, thus attenuating oxidative stress-associated disease processes. The purpose of the present study was to evaluate the effect of an exercise training program that has been previously reported to decrease alcohol consumption on blood redox status in heavy drinkers. Read More

    Characterizing conditioned reactivity to sequential alcohol-predictive cues in well-trained rats.
    Alcohol 2018 Jun 21;69:41-49. Epub 2017 Nov 21.
    Division of Pharmacology & Toxicology, Institute for Neuroscience, The University of Texas, Austin, TX, United States. Electronic address:
    Implicit learning about antecedent stimuli and the unconditional stimulus (US) properties of alcohol may facilitate the progressive loss of control over drinking. To model this learning, Cofresí et al. (2017) developed a procedure in which a discrete, visual conditional stimulus (houselight illumination; CS) predicted the availability of a retractable sipper that rats could lick to receive unsweetened alcohol [Alcoholism: Clinical and Experimental Research, 41, 608-617]. Read More

    Prevention of alcohol-induced DNA damage by a proprietary glycyrrhizin/D-mannitol product: A randomized, placebo-controlled, cross-over human study.
    Alcohol 2018 Jun 6;69:33-39. Epub 2017 Nov 6.
    Creighton University, 7068 Maumee Valley Court, Frisco, TX 75034, United States. Electronic address:
    Objectives: The purpose of the present study was to evaluate the ability of a proprietary combination of glycyrrhizin and D-mannitol to protect against oxidative damage to DNA associated with acute alcohol consumption by human subjects in a randomized, placebo-controlled cross-over designed study. Excessive alcohol consumption is associated with numerous diseases. Alcohol has been shown to generate reactive oxygen species that can result in DNA damage, leading to genetic and epigenetic changes. Read More

    Enhanced sensitivity to socially facilitating and anxiolytic effects of ethanol in adolescent Sprague Dawley rats following acute prenatal ethanol exposure.
    Alcohol 2018 Jun 6;69:25-32. Epub 2017 Nov 6.
    Department of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University, Binghamton, NY 13902, United States; Developmental Exposure Alcohol Research Center, Binghamton, NY 13902, United States. Electronic address:
    Emerging evidence suggests that deficits in social functioning and social anxiety are associated with adolescent alcohol use. Our previous research has shown that acute exposure to a high dose of ethanol on gestational day (G) 12 produces social alterations in adolescent Sprague Dawley rats. The present study assessed whether these social alterations can affect sensitivity to acute ethanol challenge during adolescence. Read More

    The contributions of Dr. Kathleen K. Sulik to fetal alcohol spectrum disorders research and prevention.
    Alcohol 2018 Jun 20;69:15-24. Epub 2018 Mar 20.
    VA Boston Healthcare System, Harvard Medical School, Boston University School of Medicine, 1400 VFW Parkway, West Roxbury, MA 02132, United States.
    Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981 Science paper describing the early gestational window when alcohol can cause the craniofacial malformations characteristic of FAS, Kathy has contributed a vast amount of research furthering our knowledge of FASD. Read More

    Proceedings of the 2017 annual meeting of the Fetal Alcohol Spectrum Disorders study group.
    Alcohol 2018 Jun 1;69:7-14. Epub 2017 Nov 1.
    Department of Pediatrics, University of Maryland, Baltimore, MD, United States.
    The 2017 Fetal Alcohol Spectrum Disorders Study Group (FASDSG) meeting was titled "Prenatal alcohol exposure in the context of multiple factors affecting brain development." The theme was reflected in the interactions between members of the Teratology Society and the FASDSG this year. The first keynote speaker, Elaine Faustman, Ph. Read More

    Yawning elicited by intravenous ethanol in rhesus monkeys with experience self-administering cocaine and ethanol: Involvement of dopamine D receptors.
    Alcohol 2018 Jun 17;69:1-5. Epub 2017 Oct 17.
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
    Characterization of the effects of long-term alcohol consumption on the brain would be aided by the development of behavioral assays that are relatively easy to implement in animal models of alcohol use disorders. Assessing unconditioned behaviors, such as drug-elicited yawning in models that permit long-term alcohol ingestion, may be a valuable complement to more invasive and costly procedures. The present studies investigated previous unexpected findings of ethanol-induced yawning in nonhuman primates. Read More

    Borderline personality disorder symptoms in treatment-naïve actively drinking alcoholics.
    Alcohol 2018 May 31;68:81-89. Epub 2017 Oct 31.
    Neurobehavioral Research, Inc., 77 Ho'okele Street, 3rd Floor, Kahului, Maui, HI 96732, United States. Electronic address:
    Borderline personality disorder (BPD) is often a complicating comorbid factor in alcohol use disorders and substance use disorders. Previous work showed that abstinent alcoholics endorsed lifetime and current symptoms of most of the BPD criteria at much higher rates than controls, with much higher symptom counts for short-term abstinent alcoholic (STAA) women than men, which is consistent with such symptoms negatively affecting female alcoholics' ability to maintain abstinence. Because prior work has also shown that treatment-naïve alcoholics (TNA) are not the same as treated alcoholics observed earlier in their alcohol dependence, but rather are a different population with potentially lower psychiatric comorbidity, in this study we compared BPD symptom criteria between TNA samples of comparable age to the control and STAA samples, including both men and women and individuals dependent on alcohol only or with lifetime dependence on both alcohol and drugs. Read More

    Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice.
    Alcohol 2018 May 31;68:71-79. Epub 2017 Oct 31.
    Departmento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, SP, 05508-900, Brazil. Electronic address:
    The peculiar neurochemical profile of the adolescent brain renders it differently susceptible to several stimuli, including stress and/or drug exposure. Among several stress mediators, nitric oxide (NO) has a role in stress responses. We have demonstrated that adolescent mice are less sensitive to ethanol-induced sensitization than adult mice. Read More

    The corticotropin releasing factor binding protein: A strange case of Dr. Jekyll and Mr. Hyde in the stress system?
    Alcohol 2017 Oct 13. Epub 2017 Oct 13.
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Department of Behavioral and Social Sciences, 121 South Main Street, Brown University, Providence, RI 02919, USA; Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, NIAAA and NIDA, NIH, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address:
    The corticotropin releasing factor (CRF) exerts its effects by acting on its receptors and on the binding protein (CRFBP). Extensive literature suggests a role of CRF in alcohol use disorder (AUD). Less is known about the specific role, if any, of CRFBP in AUD. Read More

    Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice.
    Alcohol 2018 May 30;68:63-70. Epub 2017 Sep 30.
    Titus Family Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, United States. Electronic address:
    Purinergic P2X4 receptors (P2X4Rs) belong to the P2X superfamily of ionotropic receptors that are gated by adenosine 5'-triphosphate (ATP). Accumulating evidence indicates that P2X4Rs play an important role in regulation of ethanol intake. At the molecular level, ethanol's inhibitory effects on P2X4Rs are antagonized by ivermectin (IVM), in part, via action on P2X4Rs. Read More

    Association between alcoholism and the gene encoding the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha in the Japanese population.
    Alcohol 2018 May 12;68:59-62. Epub 2017 Oct 12.
    Department of Biology, William Paterson University, 300 Pompton Road, Wayne, NJ 07470-2103, United States.
    The endocannabinoid system has been recognized to be involved in neuropsychiatric diseases. 2-arachidonoyl glycerol (2-AG) is one of the two main endocannabinoids, and their regulation could play roles in disorders under environmental influence. This study investigated the involvement of the 2-AG biosynthesizing enzyme diacylglycerol lipase alpha (DAGLA) in the pathogenesis of alcoholism. Read More

    Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure.
    Alcohol 2018 May 12;68:49-58. Epub 2017 Aug 12.
    Department of Nutrition, University of California-Davis, Davis, CA, United States. Electronic address:
    Excessive alcohol consumption has been shown to increase serum plasma levels of numerous immune cytokines. Maternal immune activation and elevated cytokines have been implicated in certain neurological disorders (e.g. Read More

    Gene expression changes in the ventral hippocampus and medial prefrontal cortex of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.
    Alcohol 2018 May 14;68:37-47. Epub 2017 Sep 14.
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, United States; Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
    Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences, including decreased hippocampal and prefrontal cortex volume and deficits in memory. We used RNA sequencing to assess the effects of adolescent binge drinking on gene expression in these regions. Male adolescent alcohol-preferring (P) rats were exposed to repeated binge drinking (three 1-h sessions/day during the dark/cycle, 5 days/week for 3 weeks starting at 28 days of age; ethanol intakes of 2. Read More

    Alcohol-naïve USVs distinguish male HAD-1 from LAD-1 rat strains.
    Alcohol 2018 May 14;68:9-17. Epub 2017 Sep 14.
    The University of Texas at Austin, College of Pharmacy, Division of Pharmacology and Toxicology, 2409 University Avenue, Stop A1915, Austin, TX 78712, United States; Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, Stop A4800, Austin, TX 78712, United States. Electronic address:
    Ultrasonic vocalizations (USVs) are mediated through specific dopaminergic and cholinergic neural pathways and serve as real-time measures of positive and negative emotional status in rodents. Although most USV studies focus primarily on USV counts, each USV possesses a number of characteristics shown to reflect activity in the associated neurotransmitter system. In the present study, we recorded spontaneously emitted USVs from alcohol-naïve high alcohol drinking (HAD-1) and low alcohol drinking (LAD-1) rats. Read More

    An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice.
    Alcohol 2018 May 6;68:19-35. Epub 2017 Sep 6.
    VA Portland Health Care System and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA.
    Despite acceptance that risk for alcohol-use disorder (AUD) has a large genetic component, the identification of genes underlying various components of risk for AUD has been hampered in humans, in part by the heterogeneity of expression of the phenotype. One aspect of AUD is physical dependence. Alcohol withdrawal is a serious consequence of alcohol dependence with multiple symptoms, many of which are seen in multiple species, and can be experienced over a wide-ranging time course. Read More

    Imaging mass spectrometry of frontal white matter lipid changes in human alcoholics.
    Alcohol 2018 03 17;67:51-63. Epub 2017 Aug 17.
    Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia.
    Background: Chronic alcohol use disorders (AUD) are associated with white matter (WM) degeneration with altered myelin integrity. Matrix assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS) enables high throughput analysis of myelin lipid biochemical histopathology to help characterize disease mechanisms.

    Purpose: This study utilized MALDI-IMS to investigate frontal lobe WM myelin lipid abnormalities in AUD. Read More

    Difference in sensitivities of blood HDL cholesterol and LDL cholesterol levels to alcohol in middle-aged Japanese men.
    Alcohol 2018 03 23;67:45-50. Epub 2017 Aug 23.
    Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan. Electronic address:
    Blood HDL cholesterol and LDL cholesterol levels are known to be higher and lower, respectively, in drinkers than in nondrinkers, and the beneficial effects of alcohol on cholesterol metabolism are thought to mainly explain the lower risk for ischemic heart disease in light-to-moderate drinkers than in nondrinkers. However, it remains unknown whether sensitivities of HDL and LDL cholesterol levels to alcohol are different or not. The subjects of this study were 21,572 middle-aged Japanese men, and they were divided into three tertile groups for blood HDL cholesterol levels. Read More

    QTc prolongation, increased NT-proBNP and pre-clinical myocardial wall remodeling in excessive alcohol consumers: The SABPA study.
    Alcohol 2018 May 14;68:1-8. Epub 2017 Sep 14.
    Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
    Alcohol contributes greatly to vascular and structural modifications. Due to differences in the metabolism and tolerance of alcohol between ethnic groups, the manner of these modifications may differ. We investigated the association between alcohol consumption - measured via ethnic-specific gamma glutamyl transferase (γ-GT) cut-points - and markers of cardiac perfusion, electrical activity, and pre-clinical structural alterations. Read More

    Persistent light to moderate alcohol intake and lung function: A longitudinal study.
    Alcohol 2018 03 1;67:65-71. Epub 2017 Sep 1.
    Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA; ISGlobal CREAL, and Pompeu Fabra University, Barcelona, Spain.
    Alcohol intake has been inconsistently associated with lung function levels in cross-sectional studies. The goal of our study was to determine whether longitudinally assessed light-to-moderate alcohol intake is associated with levels and decline of lung function. We examined data from 1333 adult participants in the population-based Tucson Epidemiological Study of Airway Obstructive Disease. Read More

    Challenges of diagnosing fetal alcohol spectrum disorders in foster and adopted children.
    Alcohol 2018 03 24;67:37-43. Epub 2017 Aug 24.
    PALs Developmental Center, Lubbock, TX, USA; Texas Tech University Health Sciences Center, Lubbock, TX, USA.
    Fetal Alcohol Spectrum Disorders (FASD) might be 10-15 times more prevalent among foster/adopted children compared to the general population; however, many of these children remain undiagnosed or misdiagnosed. The lack of confirmed prenatal alcohol exposure (PAE) may be a key barrier to diagnosis. Our sample included 681 patients evaluated for FASD, according to the University of Washington 4-Digit Diagnostic Code, at a pediatric specialty clinic. Read More

    Alcohol operant self-administration: Investigating how alcohol-seeking behaviors predict drinking in mice using two operant approaches.
    Alcohol 2018 03 19;67:23-36. Epub 2017 Aug 19.
    Laboratory on Neurobiology of Compulsive Behaviors, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA. Electronic address:
    Alcohol operant self-administration paradigms are critical tools for studying the neural circuits implicated in both alcohol-seeking and consummatory behaviors and for understanding the neural basis underlying alcohol-use disorders. In this study, we investigate the predictive value of two operant models of oral alcohol self-administration in mice, one in which alcohol is delivered into a cup following nose-poke responses with no accurate measurement of consumed alcohol solution, and another paradigm that provides access to alcohol via a sipper tube following lever presses and where lick rate and consumed alcohol volume can be measured. The goal was to identify a paradigm where operant behaviors such as lever presses and nose pokes, as well as other tracked behavior such as licks and head entries, can be used to reliably predict blood alcohol concentration (BAC). Read More

    Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats.
    Alcohol 2018 03 19;67:15-22. Epub 2017 Aug 19.
    Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism. In the current experiments, the COMT inhibitor tolcapone was utilized in an operant behavioral model of reinforcer-seeking and drinking to determine if this compound was capable of remediating the excessive seeking and drinking phenotype of the alcohol-preferring P rat. Tolcapone was administered to male and female alcohol-reinforced P and Wistar rats. Read More

    Evaluation of a novel method for the analysis of alcohol biomarkers: Ethyl glucuronide, ethyl sulfate and phosphatidylethanol.
    Alcohol 2018 03 31;67:7-13. Epub 2017 Aug 31.
    Translational Australian Clinical Toxicology (TACT) Research Group, Discipline of Pharmacology, Sydney Medical School, University of Sydney, Australia; Centenary Institute of Cancer Medicine and Cell Biology, Camperdown, NSW, 2050, Australia. Electronic address:
    Currently available markers and methods to evaluate alcohol consumption are indirect and suboptimal, or rely on self-report, which have inherent problems. Direct metabolites of alcohol, phosphatidylethanol (PEth), ethyl sulfate (EtS), and ethyl glucuronide (EtG), are known to improve diagnostic accuracy. In this study, methods were established for the identification of PEth in erythrocytes and EtG and EtS in serum using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Read More

    Maternal hair testing to disclose self-misreporting in drinking and smoking behavior during pregnancy.
    Alcohol 2018 03 31;67:1-6. Epub 2017 Aug 31.
    BCNatal (Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Déu and Hospital Clínic), University of Barcelona, Barcelona, Spain; Maternal and Child Health and Development Network II (SAMID II), Instituto de Salud Carlos III (ISCIII), - Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (FEDER), Madrid, Spain.
    This study aimed to objectively verify smoking and drinking behavior during pregnancy and to disclose self-misreporting through maternal hair analysis. A total of 153 women attending a university hospital in Barcelona (Spain) were selected and interviewed after delivery, on their smoking and drinking habits during pregnancy. A 9-cm hair strand was collected and analyzed by liquid chromatography tandem mass spectrometry for the presence of nicotine (NIC) and ethyl glucuronide (EtG) as biomarkers of tobacco and alcohol consumption, respectively. Read More

    The effects of working memory load and attention refocusing on delay discounting rates in alcohol use disorder with comorbid antisocial personality disorder.
    Alcohol 2018 02 23;66:9-14. Epub 2017 Sep 23.
    Indiana University-Bloomington, Department of Psychological & Brain Sciences, Bloomington, IN 47405, USA. Electronic address:
    Executive working memory capacity (eWMC) is central to adaptive decision-making. Research has revealed reduced eWMC and higher rates of impulsive decision making in individuals with alcohol use disorders (AUDs: DSM-IV Alcohol Dependence of Alcohol Abuse) and antisocial psychopathology (AP). Recent work has shown that placing a load on working memory (WM) further increases impulsive decision making on the delay discounting (DD) task in those with AUDs and AP. Read More

    Alcohol withdrawal upregulates mRNA encoding for Ca2.1-α1 subunit in the rat inferior colliculus.
    Alcohol 2018 02 23;66:21-26. Epub 2017 Sep 23.
    Georgetown University Medical Center, Department of Pediatrics, Washington D.C., USA. Electronic address:
    We previously reported increased current density through P-type voltage-gated Ca channels in inferior colliculus (IC) neurons during alcohol withdrawal. However, the molecular correlate of this increased P-type channel current is currently unknown. Here, we probe changes in mRNA and protein expression of the pore-forming Ca2. Read More

    Correlation between blood alcohol concentration (BAC), breath alcohol concentration (BrAC) and psychomotor evaluation in a clinical monitored study of alcohol intake in Brazil.
    Alcohol 2018 02 7;66:15-20. Epub 2017 Oct 7.
    Faculdade de Ciências Médicas de Minas Gerais, Alameda Ezequiel Dias 275, Belo Horizonte, MG, Brazil; Instituto Medico Legal, Rua Nícias Continentino, 1291, Belo Horizonte, MG, Brazil.
    Background: Policies that establish maximum blood alcohol concentrations (BACs) or breath alcohol concentration (BrACs) for drivers while driving can reduce traffic accidents by approximately 20%. In Brazil, the National Transit Council (CONTRAN) considers positive BAC and/or BrAC tests or signs of psychomotor capacity alterations as evaluated by a police authority to be an administrative infraction or even a crime. The observed clinical symptoms of alcohol intoxication based on a subject's appearance may not necessarily reflect the quantified BAC and/or BrAC. Read More

    Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis.
    Alcohol 2018 02 23;66:1-7. Epub 2017 Sep 23.
    Centenary Institute of Cancer Medicine and Cell Biology, Camperdown, NSW 2050, Australia; Drug Health Services, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia; Faculty of Medicine, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:
    Laboratory tests can play an important role in assessment of alcoholic patients, including for evaluation of liver damage and as markers of alcohol intake. Evidence on test performance should lead to better selection of appropriate tests and improved interpretation of results. We compared laboratory test results from 1578 patients between cases (with alcoholic cirrhosis; 753 men, 243 women) and controls (with equivalent lifetime alcohol intake but no liver disease; 439 men, 143 women). Read More

    Effects of group II metabotropic glutamate receptor modulation on ethanol- and sucrose-seeking and consumption in the rat.
    Alcohol 2018 02 23;66:77-85. Epub 2017 Sep 23.
    Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
    Previous studies suggest that group II metabotropic glutamate receptors (mGluR2/3) are involved in regulating ethanol-seeking and consumption. The mGluR2/3 agonist LY379268 (LY37) and selective mGluR2 positive allosteric modulator biphenyl‑indanone A (BINA) were used to investigate the relative contribution of mGlu2 and mGlu3 receptors on ethanol- and sucrose-seeking and consumption. A microinjection study was then performed to examine the role of nucleus accumbens (NAc) core mGluR2/3 on ethanol-seeking. Read More

    Testing bidirectional relationships between alcohol use and depressive symptoms: What is the role of the serotonin transporter gene?
    Alcohol 2018 02 13;66:69-75. Epub 2017 Aug 13.
    Trimbos Institute, Utrecht, The Netherlands; Utrecht University, Utrecht, The Netherlands.
    Alcohol abuse often co-exists with a major depressive disorder. In order to understand the development of this comorbidity, it is important to concentrate on the preceding process. It has been suggested that the link between alcohol use and depressive symptoms is a result of an interaction with genetic factors. Read More

    Quantitative trait loci for sensitivity to acute ethanol and ethanol consummatory behaviors in rats.
    Alcohol 2018 02 12;66:55-67. Epub 2017 Aug 12.
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:
    Individuals with a low initial response to alcohol (i.e., ethanol) are at greater risk of developing alcohol abuse or dependence later in life. Read More

    Examining the effects of alcohol on GABA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells.
    Alcohol 2018 02 12;66:45-53. Epub 2017 Aug 12.
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, 06030-1410, USA; Institute for Systems Genomics, University of Connecticut, Storrs, CT, 06268, USA. Electronic address:
    Factors influencing the development of alcohol-use disorder (AUD) are complex and heterogeneous. While animal models have been crucial to identifying actions of alcohol on neural cells, human-derived in vitro systems that reflect an individual's genetic background hold promise in furthering our understanding of the molecular and functional effects of alcohol exposure and the pathophysiology of AUD. In this report, we utilized induced pluripotent stem cell (iPSCs)-derived neural cell cultures obtained from healthy individuals (CTLs) and those with alcohol dependence (ADs) to 1) examine the effect of 21-day alcohol exposure on mRNA expression of three genes encoding GABA receptor subunits (GABRA1, GABRG2, and GABRD) using quantitative PCR, and 2) examine the effect of acute and chronic alcohol exposure on GABA-evoked currents using whole-cell patch-clamp electrophysiology. Read More

    Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting.
    Alcohol 2018 02 23;66:35-43. Epub 2017 Sep 23.
    Alcohol Research Program, Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. Electronic address:
    On November 18, 2016 the 21st annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the Center for Translational Research and Education at Loyola University Chicago's Health Sciences Campus in Maywood, IL. The 2016 meeting focused broadly on alcohol and inflammation, epigenetics, and the microbiome. The four plenary sessions of the meeting were Alcohol, Inflammation, and Immunity; Alcohol and Epigenetics; Alcohol, Transcriptional Regulation, and Epigenetics; and Alcohol, Intestinal Mucosa, and the Gut Microbiome. Read More

    Regional dysregulation of taurine and related amino acids in the fetal rat brain following gestational alcohol exposure.
    Alcohol 2018 02 30;66:27-33. Epub 2017 Sep 30.
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA. Electronic address:
    The fetal brain exhibits exquisite alcohol-induced regional neuronal vulnerability. A candidate mechanism for alcohol-mediated brain deficits is disruption of amino acid (AA) bioavailability. AAs are vitally important for proper neurodevelopment, as they comprise the most abundant neurotransmitters in the brain and act as neurotransmitter precursors, nitric oxide donors, antioxidants, and neurotrophic factors, which induce synaptogenesis, neuronal proliferation, and migration. Read More

    Impact of a brief intervention on reducing alcohol use and increasing alcohol treatment services utilization among alcohol- and drug-using adult emergency department patients.
    Alcohol 2017 Dec 23;65:71-80. Epub 2017 Sep 23.
    Department of Emergency Medicine, Alpert Medical School, Brown University, Providence, RI, USA.
    Most previous brief intervention (BI) studies have focused on alcohol or drug use, instead of both substances. Our primary aim was to determine if an alcohol- and drug-use BI reduced alcohol use and increased alcohol treatment services utilization among adult emergency department (ED) patients who drink alcohol and require an intervention for their drug use. Our secondary aims were to assess when the greatest relative reductions in alcohol use occurred, and which patients (stratified by need for an alcohol use intervention) reduced their alcohol use the most. Read More

    Hazardous alcohol use among patients with schizophrenia and depression.
    Alcohol 2017 Dec 22;65:63-69. Epub 2017 Sep 22.
    Research Division, Institute of Mental Health, Buangkok Green Medical Park, 10 Buangkok View, Singapore 539747, Singapore.
    Aims: The current study aimed to 1) report the prevalence of hazardous alcohol use in an outpatient population among those with schizophrenia and depressive disorders, 2) assess the sociodemographic and clinical correlates of hazardous alcohol use, 3) examine the association of hazardous alcohol use with severity of depression, anxiety and smoking, and 4) assess the association of hazardous alcohol use with quality of life.

    Methods: Three hundred ten outpatients seeking treatment at a tertiary psychiatric institute with a diagnosis of either schizophrenia spectrum disorder or depressive disorder were included in the study. Patients were assessed for hazardous alcohol use using the Alcohol Use Disorders Identification Test. Read More

    Progressive white matter atrophy with altered lipid profiles is partially reversed by short-term abstinence in an experimental model of alcohol-related neurodegeneration.
    Alcohol 2017 Dec 15;65:51-62. Epub 2017 Sep 15.
    Liver Research Center, Division of Gastroenterology, Department of Medicine, Brown University, Providence, RI, USA; Departments of Neurology, Neurosurgery, and Pathology, Brown University, Providence, RI, USA; Rhode Island Hospital, The Alpert Medical School of Brown University, Providence, RI, USA. Electronic address:
    Chronic ethanol exposure causes white matter (WM) atrophy and degeneration with major impairments in the structural integrity of myelin. Since myelin is composed of oligodendrocyte lipid-rich membranes, understanding the consequences and reversibility of alcohol-related oligodendrocyte dysfunction in relation to myelin structure could provide new insights into the pathogenesis of WM degeneration and potential strategies for treatment. Adult male Long Evans rats were pair-fed with isocaloric liquid diets containing 0% or 26% ethanol (caloric) for 3 or 8 weeks. Read More

    Urinary bladder volume measured in whole-body CT scans is a useful marker for alcohol intoxication.
    Alcohol 2017 Dec 23;65:45-50. Epub 2017 Sep 23.
    Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany. Electronic address:
    Purpose: The aim of this study was to investigate whether urinary bladder volume (UBV) and blood alcohol concentration (BAC) correlate in a cohort of emergency trauma patients. Furthermore, the feasibility of semi-automated 3D-CT volumetry for urinary bladder volumetry calculations in whole-body CT examinations was elucidated.

    Material And Methods: Whole-body CT scans of 831 individuals treated in the emergency department with suspected multiple injuries were included. Read More

    First description and evaluation of SNPs in the ADH and ALDH genes in a population of alcoholics in Central-West Brazil.
    Alcohol 2017 Dec 23;65:37-43. Epub 2017 Sep 23.
    Laboratório de Genética Molecular e Citogenética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Avenida Esperança, s/n, Campus Samambaia (Campus II), Goiânia, GO, CEP: 74690-900, Brazil. Electronic address:
    Worldwide, different studies have reported an association of alcohol-use disorder (AUD) with different types of Single Nucleotide Polymorphisms (SNPs) in the genes for aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH). In Brazil, there is little information about the occurrence of these SNPs in the AUD population and an absence of studies characterizing the population in the Central-West Region of Brazil. Actually, in Brazil, there are more than 4 million people with AUD. Read More

    THC inhibits the expression of ethanol-induced locomotor sensitization in mice.
    Alcohol 2017 Dec 21;65:31-35. Epub 2017 Sep 21.
    Department of Physiological Sciences, Faculdade de Ciências Médicas Santa Casa de São Paulo, Rua Dr. Cesário Motta Jr., 61, São Paulo, SP, Cep: 01221-020, Brazil. Electronic address:
    The motivational circuit activated by ethanol leads to behavioral changes that recruit the endocannabinoid system (ECS). Case reports and observational studies suggest that the use of Cannabis sp. mitigates problematic ethanol consumption in humans. Read More

    Increased risk of peripheral arterial disease in patients with alcohol intoxication: A population-based retrospective cohort study.
    Alcohol 2017 Dec 15;65:25-30. Epub 2017 Sep 15.
    Molecular and Genomic Epidemiology Center, China Medical University Hospital, Taichung, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan. Electronic address:
    Previous studies have reported that light-to-moderate drinkers have a lower risk of peripheral arterial disease (PAD) than abstainers, and that heavy drinking increases the risk of PAD. However, reports of the effects of severe alcohol drinking on PAD are lacking within a population-based cohort. Alcohol intoxication is typically considered a medical emergency at clinics in Taiwan and is commonly attributed to excessive alcohol use. Read More

    1 OF 57