2,931 results match your criteria Alcohol [Journal]


Good outcome of living donor liver transplantation for severe alcoholic hepatitis not responding to medical management: A single center experience of 39 patients.

Alcohol 2018 Jul 24;77:27-30. Epub 2018 Jul 24.

Medanta Institute of Liver Transplantation and Regenerative Medicine, Medanta The Medicity, Gurgaon, Delhi (NCR), India.

Introduction: There are limited data on outcomes of living donor liver transplantation (LDLT) for patients with severe alcoholic hepatitis.

Methods: The study included LDLT recipients for severe alcoholic hepatitis (n = 39) who did not improve with medical treatment and compared their outcomes with patients who underwent LDLT for alcoholic liver disease (n = 461). The diagnosis of severe alcoholic hepatitis was based on both clinical and explants data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.009DOI Listing

Alcohol consumption and cardiovascular health: A nationwide survey of Uruguayan cardiologists.

Alcohol 2019 Feb 12. Epub 2019 Feb 12.

Division of Cardiology, Kingston Health Sciences Centre, Queen's University, Kingston, Ontario, Canada. Electronic address:

Background And Aims: Heavy alcohol use is a risk factor for disease and mortality; however epidemiological findings have demonstrated protective effects of a light-to-moderate intake of alcohol on cardiovascular health. There are many misconceptions regarding appropriate levels of alcohol intake and the risks and benefits of consumption. We sought to examine physician attitudes and recommendations regarding alcohol intake in a cohort of Uruguayan cardiologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2019.02.002DOI Listing
February 2019

Status of inflammation and alcohol use in a 6-month follow-up study of patients with major depressive disorder.

Alcohol 2019 Feb 12. Epub 2019 Feb 12.

University of Tampere, Faculty of Medicine and Life Sciences, 33014 University of Tampere, Finland and Seinäjoki Central Hospital, Department of Psychiatry, 60220 Seinäjoki, Finland.

Introduction: The studies on the relations between alcohol consumption, the status of inflammation and depression have produced conflicting results. In this study we followed patients with major depressive disorders by monitoring biomarkers of inflammation together with biomarkers of heavy alcohol use.

Method: The levels of IL-6 (interleukin-6), IL-8 (interleukin-8), hs-CRP (high sensitivity C-reactive protein), YKL-40 (also known as Chitinase-3-like protein 1 or CHI3L1) and biomarkers of alcohol consumption and liver status (GT, CDT, ALT, alkaline phosphatase) were measured at baseline and after 6 months of psychiatric treatment from 242 patients suffering from current major depressive disorder (MDD) with (n = 99) or without (n = 143) alcohol use disorder (AUD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2019.02.001DOI Listing
February 2019
1 Read

Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Alcohol 2018 Aug 24;77:11-18. Epub 2018 Aug 24.

Department of Surgery, Alcohol Research Program, Burn & Shock Trauma Research Institute, Loyola University Chicago Health Sciences Division, Maywood, IL, United States. Electronic address:

On January 26, 2018, the 23rd annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado. The meeting consisted of plenary sessions with oral presentations and a poster presentation session. There were four plenary sessions that covered a wide range of topics relating to alcohol use: Alcohol and Liver Disease; Alcohol, Inflammation and Immune Response; Alcohol and Organ Injury; Heath Consequences and Alcohol Drinking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.08.010DOI Listing
August 2018
1 Read

Cardiovascular effects of alcohol: A double-edged sword / how to remain at the nadir point of the J-Curve?

Alcohol 2018 Aug 29;76:117-129. Epub 2018 Aug 29.

Third Department of Cardiology, Athens University School of Medicine, Athens, Greece. Electronic address:

Background: In addition to its established harmful effects on the liver and other organs, heavy alcohol use confers deleterious effects on the cardiovascular (CV) system, as well. However, data have emerged that light/moderate alcohol consumption (1 drink/day for women and 1-2 drinks/day for men) may be protective against CV disease.

Objective/methods: English articles regarding the CV effects of alcohol/ethanol were reviewed by search in Medline, Scopus, and Google Scholar. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.08.011DOI Listing

Objective Continuous Monitoring of Alcohol Consumption for Three Months Among Alcohol Use Disorder Treatment Outpatients.

Alcohol 2019 Jan 30. Epub 2019 Jan 30.

Center for Alcohol and Addiction Studies, Brown University, Box G-S121-5, Providence, RI 02912, USA.

Background: Transdermal alcohol sensing technology allows for objective continuous monitoring of alcohol use. The purpose of this study was to characterize alcohol consumption measured with this technology among alcohol use disorder treatment outpatients in two clinical trials.

Methods: Participants were community-based alcohol treatment outpatients in usual care (N = 63) during the first three years of studies that monitored drinking with the secure continuous remote alcohol monitor (SCRAMx®) ankle bracelet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2019.01.008DOI Listing
January 2019

Beer consumption negatively regulates hormonal reproductive status and reduces apoptosis in Leydig cells in peripubertal rats.

Alcohol 2019 Jan 25. Epub 2019 Jan 25.

Division of Nutritional Physiology, Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (WULS-SGGW), Warsaw, Poland. Electronic address:

Beer is one of the most popular type of alcoholic beverage consumed by young people, that is associated with ethanol intake resulted in harmful effects also within the reproductive system. Bioactive compounds occurring in beer may diminish the toxic effect of ethanol. However, there is still too little of knowledge about the effect of beer consumption on hormonal regulation of male reproduction in organisms exposed to alcohol since peripubertal age. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183009
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2019.01.009DOI Listing
January 2019
3 Reads

Examining the influence of blood alcohol level on the incidence of pneumonia & sepsis complications following traumatic injury.

Alcohol 2018 Aug 4;76:111-115. Epub 2018 Aug 4.

Department of Research Administration, Jersey Shore University Medical Center, Neptune, NJ, United States.

Background: The purpose of this study was to examine the impact of blood alcohol concentration (BAC) on the occurrence of pneumonia and sepsis among traumatic injury victims.

Methods: Retrospective study data were retrieved from the 2007-2010 National Trauma Data Bank and included all patients ≥14 years of age, with a "blunt" or "penetrating" injury, who were taken to a level 1 or level 2 trauma center, had complete systolic blood pressure and heart rate records, and had a confirmed blood alcohol test at the time of hospital arrival. Patients' characteristics and outcome information were compared between two groups (those with a BAC above the legal limit [>0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.011DOI Listing
August 2018
1 Read

Emotional and autonomic dysregulation in abstinent alcoholic men: An idiosyncratic profile?

Alcohol 2019 Jan 18. Epub 2019 Jan 18.

Department of Psychobiology, University of Valencia, Spain.

Men who misuse alcohol tend to experience negative affect, which may entail difficulties regulating emotions to cope effectively with stressful or anxiety-provoking situations, increasing the risk of alcohol relapse. This dysphoric state has been associated with alexithymia, which compromises an individual's abilities to acknowledge, recognize and regulate emotional states. A physiological correlate of emotional regulation is autonomic flexibility, emotional dysregulation in men who misuse alcohol being correlated with reduced parasympathetic activation to control heart rate variability during stress and/or conflict situations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2019.01.007DOI Listing
January 2019
1 Read

Absence of compulsive drinking phenotype in adult male rats exposed to ethanol in a binge-like pattern during adolescence.

Alcohol 2019 Jan 18. Epub 2019 Jan 18.

Department of Neuroscience, Medical University of South Carolina, Charleston SC 29425, United States. Electronic address:

The abuse of alcohol during adolescence is widespread and represents a particular concern given that earlier age of drinking onset is associated with increased risk for the development of alcohol use disorders (AUDs). Despite this risk, it remains unclear whether binge-like adolescent alcohol exposure facilitates drinking despite aversive consequences, a characteristic common among individuals with AUDs. The present study examined voluntary alcohol consumption and aversion-resistant drinking in adult male Long-Evans rats that had undergone adolescent intermittent ethanol (AIE) exposure by vapor inhalation between post-natal days (PD) 28-44. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183029
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2019.01.006DOI Listing
January 2019
3 Reads

Usefulness of Adult Medaka Fish as a Model for the Evaluation of Alcoholic Fatty Liver.

Alcohol 2019 Jan 17. Epub 2019 Jan 17.

Center for Regenerative Medicine, Yamaguchi University School of Medicine, Minami Kogushi 1-1-1, Ube Yamaguchi 755-8505, Japan; Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube Yamaguchi 755-8505, Japan.

Alcohol has long been acknowledged to be one of the main causes of hepatic disorders. In recent years, with the advancements in antiviral therapies, the relative proportion alcoholic liver disease constitutes among liver diseases has increased, necessitating the establishment of a useful model for the elucidation of the mechanism of its development. In this study, we developed a model of alcoholic liver disease using medaka, a small-sized fish known for its usefulness as a model organism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2019.01.005DOI Listing
January 2019
1 Read

Alcohol Use Disorder and Alcohol Withdrawal Syndrome in Vietnamese Hospitalized Patients.

Alcohol 2019 Jan 17. Epub 2019 Jan 17.

Social and Administrative Pharmacy Department, Faculty of Pharmaceutical Sciences, Chulalongkorn University. Bangkok, Thailand. Electronic address:

Aims: To identify the extent to which patients admitted to a general hospital in Vietnam meet the criteria for risky alcohol drinking, alcohol use disorder (AUD), and alcohol withdrawal syndrome (AWS), describe problems and behavior of alcohol use such as types and quantity of alcohol drinking in a hospitalized population in Vietnam and investigate the association among age, disease-related factors and alcohol consumption with AWS.

Methods: This study was conducted prospectively in 1340 patients admitted to a general hospital. All patients were screened for risky alcohol drinking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2019.01.004DOI Listing
January 2019
2 Reads

Effects of Rat Strain and Method of Inducing Ethanol Drinking on Pavlovian-Instrumental-Transfer with Ethanol-Paired Conditioned Stimuli.

Alcohol 2019 Jan 11. Epub 2019 Jan 11.

Designer Drug Unit, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Blvd, Baltimore, MD 21224, USA.

Ethanol-paired Conditioned Stimuli are widely thought to invigorate ethanol responding, and thus, precipitate relapse to drinking. However, preclinical studies investigating this issue using Pavlovian Instrumental Transfer (PIT) procedures have had mixed results, with some studies finding PIT while others did not. The studies failing to show PIT used Lewis rats and induced ethanol drinking using a post-prandial drinking procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2019.01.003DOI Listing
January 2019
2 Reads

Consumption of illegal home-made alcohol in Malawi: A neglected public health threat.

Alcohol 2019 Mar 10;75:99-103. Epub 2018 Aug 10.

Food Technology and Nutrition Group, Lilongwe University of Agriculture and Natural Resources (LUANAR)-NRC Campus, P.O. Box 143, Lilongwe, Malawi.

This study assessed the ethanol and methanol contents of homemade spirit (Kachasu) sold in Blantyre, Malawi. The likelihood of ethanol and methanol toxicity, respectively, was determined through Monte Carlo simulations using reported Kachasu intake volumes of 21 consumers and the determined methanol and ethanol contents. Ethanol concentration, in samples from 20 different distillers, ranged from 11 to 55% v/v. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173101
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.08.003DOI Listing
March 2019
4 Reads

In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).

Alcohol 2019 Mar 24;75:113-121. Epub 2018 Jul 24.

Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, Korea University, College of Medicine, Seoul, Republic of Korea. Electronic address:

In reference to the auditory manifestation of fetal alcohol syndrome, previous work has preferentially focused on the deviant neural development of the auditory system. Changes in the sensory hair cell, the ultimate sensory organ, were not well understood. In this study, we carried out an in vivo assessment of the embryonic hair cell changes on the lateral line of zebrafish upon exposure to various ethanol concentrations (0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173094
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.07.008DOI Listing
March 2019
5 Reads

Alcohol use and associated factors among physicians and nurses in northeast Brazil.

Alcohol 2019 Mar 19;75:105-112. Epub 2018 Jul 19.

Federal University of Maranhao, Sao Luis, Brazil. Electronic address:

The consequences of alcohol use are closely related to its pattern of intake. The aim of this study is to analyze the pattern of alcohol use by doctors and nurses. Associated co-factors have also been considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.002DOI Listing
March 2019
1 Read

Ethanol Activates Immune Response In Lymphoblastoid Cells.

Alcohol 2019 Jan 8. Epub 2019 Jan 8.

Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, United States; Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States.

The short term effects of alcohol on gene expression in brain tissue cannot directly be studied in humans. Because neuroimmune signaling is altered by alcohol, immune cells are a logical, accessible choice to study and might provide biomarkers. RNAseq was used to study the effects of 48 h exposure to ethanol on lymphoblastoid cell lines (LCLs) from 21 alcoholics and 21 controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2019.01.001DOI Listing
January 2019
1 Read

Optogenetic investigation of neural mechanisms for alcohol-use disorder.

Alcohol 2019 Feb 19;74:29-38. Epub 2018 Jun 19.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

Optogenetic techniques have been widely used in the study of neuropsychiatric diseases such as anxiety, depression, and drug addiction. Cell-type specific targeting of optogenetic tools to neurons has contributed to a tremendous understanding of the function of neural circuits for future treatment of neuropsychiatric disorders. Though optogenetics has been widely used in many research areas, the use of optogenetic tools to uncover and elucidate neural circuit mechanisms of alcohol's actions in the brain are still developing. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183004
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.005DOI Listing
February 2019
8 Reads

Gene-edited CRISPy Critters for alcohol research.

Authors:
Gregg E Homanics

Alcohol 2019 Feb 7;74:11-19. Epub 2018 Mar 7.

Department of Anesthesiology, University of Pittsburgh School of Medicine, 6060 Biomedical Science Tower-3, 3501 Fifth Avenue, Pittsburgh, PA 15261, United States; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, 6060 Biomedical Science Tower-3, 3501 Fifth Avenue, Pittsburgh, PA 15261, United States; Department of Neurobiology, University of Pittsburgh School of Medicine, 6060 Biomedical Science Tower-3, 3501 Fifth Avenue, Pittsburgh, PA 15261, United States. Electronic address:

Genetically engineered animals are powerful tools that have provided invaluable insights into mechanisms of alcohol action and alcohol-use disorder. Traditionally, production of gene-targeted animals was a tremendously expensive, time consuming, and technically demanding undertaking. However, the recent advent of facile methods for editing the genome at very high efficiency is revolutionizing how these animals are made. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334660PMC
February 2019
2 Reads

The Effect of Voluntary Wheel Running on 129/SvEvTac and C3H/Ibg Alcohol Consumption.

Alcohol 2018 Oct 25. Epub 2018 Oct 25.

University of Colorado, Institute for Behavioral Genetics, 1480 30th Street, 447 UCB, Boulder, CO, 80309-0447, USA; Department of Integrative Physiology, 354 UCB, Boulder, CO, 80309-0354, USA. Electronic address:

The mesolimbic dopaminergic reward pathway is activated by both alcohol and exercise, suggesting exercise as a possible treatment or preventative method for alcohol use disorders (AUDs). Prior studies conducted in our lab have demonstrated the hedonic substitution of voluntary alcohol consumption for voluntary wheel running in female C57Bl/6Ibg mice, and a trend in male C57Bl/6Ibg mice. Given the important contribution of genetic background on AUDs, this study aims to assess the effects of voluntary wheel running on voluntary alcohol consumption in two moderate alcohol consuming strains of mice, C3H/Ibg and 129/SvEvTac. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183018
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.007DOI Listing
October 2018
7 Reads

Alcohol-associated antecedent stimuli elicit alcohol seeking in non-dependent rats and may activate the insula.

Alcohol 2018 Aug 17;76:91-102. Epub 2018 Aug 17.

The University of Texas at Austin, Austin, TX, United States; Institute for Neuroscience, The University of Texas at Austin, Austin, TX, United States; Department of Psychology, The University of Texas at Austin, Austin, TX, United States. Electronic address:

Alcohol self-administration produces brain and behavior adaptations that facilitate a progressive loss of control over drinking and contribute to relapse. One possible adaptation is the ability of antecedent environmental stimuli that are consistently paired with alcohol to trigger alcohol-seeking behaviors. We previously modeled this adaptation in rats using a Pavlovian conditioning procedure in which illumination of a houselight preceded the presentation of a sipper tube that produced unsweetened alcohol when licked. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183000
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.08.004DOI Listing
August 2018
6 Reads

Effect of Nanoformulated Copper/Zinc Superoxide Dismutase on Chronic Ethanol-Induced Alterations in Liver and Adipose Tissue.

Alcohol 2019 Jan 3. Epub 2019 Jan 3.

Department of Internal Medicine, Divisions of Diabetes, Endocrinology, and Metabolism, USA; VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA. Electronic address:

Background: We previously reported that nanoformulated copper/zinc superoxide dismutase (Nano) attenuates non-alcoholic fatty liver disease and adipose tissue (AT) inflammation in obese animals. Here, we sought to determine whether Nano treatment attenuates alcohol-associated liver disease (AALD) and AT inflammation in alcohol-fed mice.

Methods: We pre-treated E-47 cells (HepG2 cells that over-express CYP2E1) with native- or nano- SOD for 6 h, followed by treatment with ethanol and/or linoleic acid (LA), a free fatty acid. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183025
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.12.005DOI Listing
January 2019
5 Reads

Influence of low-dose alcohol consumption on post-ischemic inflammation: Role of cystathionine γ-lyase.

Alcohol 2018 Aug 21;76:81-89. Epub 2018 Aug 21.

Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, United States. Electronic address:

Low-dose alcohol consumption (LAC) has been shown to suppress post-ischemic inflammation and alleviate cerebral ischemia/reperfusion (I/R) injury. Cystathionine γ-Lyase (CSE) is one of the enzymes that endogenously produce hydrogen sulfide (HS), which has an anti-inflammatory property at low concentration. We determined the potential role of CSE in the protective effect of LAC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.08.005DOI Listing
August 2018
2 Reads

Physical fitness and physical activity levels in people with alcohol use disorder versus matched healthy controls: A pilot study.

Alcohol 2018 Aug 8;76:73-79. Epub 2018 Aug 8.

KU Leuven - University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium; KU Leuven - University of Leuven, University Psychiatric Centre (UPC) KU Leuven, Leuven-Kortenberg, Belgium.

Low physical fitness and physical inactivity have been recognized as prominent behavioral risk factors for cardiovascular diseases and an independent risk factor for all-cause mortality. To date, no studies have ystematically assessed physical fitness and physical activity in patients with alcohol use disorders (AUD) vs. a healthy comparison group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.014DOI Listing
August 2018
3 Reads

Offspring of male rats exposed to binge alcohol exhibit heightened ethanol intake at infancy and alterations in T-maze performance.

Alcohol 2018 Aug 9;76:65-71. Epub 2018 Aug 9.

Department of Psychology, Southern Connecticut State University, New Haven, CT, United States. Electronic address:

Alcohol use is associated with a variety of negative consequences, including heightened likelihood of cognitive impairment, proclivity to alcohol use disorders (AUD), and alterations in the drinker's offspring. Children and rodents exposed to alcohol during pregnancy, or those whose fathers consumed alcohol prior to mating, often exhibit neurodevelopmental, physiological, and behavioral deficits. The present study assessed cognitive function and alcohol intake in male and female rats that were offspring of alcohol-exposed fathers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368891PMC
August 2018
1 Read

No blue-yellow color vision impairment after acute ethanol ingestion.

Alcohol 2018 Jul 17;76:59-63. Epub 2018 Jul 17.

Institute of Forensic Medicine, University of Bern, Bühlstrasse 20, CH-3012 Bern, Switzerland. Electronic address:

Several studies showed that chronic ethanol exposure can cause color vision deficiencies. There has been no agreement about the axis of color defects due to alcohol misuse since changes in the red-green and the blue-yellow axis have been described in literature. The acute influence of alcohol on the blue-yellow color vision has not been studied as well. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173044
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.07.003DOI Listing
July 2018
4 Reads

Diallyl Disulfide inhibits ethanol-induced pulmonary cell vitamin D and antimicrobial peptide Cathelicidin depletion.

Alcohol 2018 Dec 20. Epub 2018 Dec 20.

Department of Global Environmental Health Sciences, Tulane University, School of Public Health and Tropical Medicine, New Orleans, Louisiana. Electronic address:

Ethanol has been found to affect pulmonary cells by interfering with vitamin D metabolism and pulmonary defense mechanisms. The objective of this study was to understand the mechanisms of ethanol's disruptive influence on the vitamin D pathway and inhibition of anti-microbial peptide cathelicidin (LL-37). Bronchial epithelial cells (BEAS-2Bs), primary human bronchial epithelial cells (HBECs), primary human alveolar epithelial cells (HPAEpiCs), and human monocyte cells (THP-1s) were used in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.12.003DOI Listing
December 2018
2 Reads

Role of zinc insufficiency in fetal alveolar macrophage dysfunction and RSV exacerbation associated with fetal ethanol exposure.

Alcohol 2018 Dec 20. Epub 2018 Dec 20.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Emory University, Atlanta, GA 30322, United States. Electronic address:

Background: We previously reported that maternal alcohol use significantly increases the risk of sepsis in premature and term newborns. In the mouse, fetal ethanol exposure results in an immunosuppressed phenotype for the alveolar macrophage (AM) and decreases bacterial phagocytosis. In pregnant mice, ethanol decreased AM zinc homeostasis which contributed to immunosuppression and impaired AM phagocytosis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183018
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.11.007DOI Listing
December 2018
10 Reads

Impact of moderate prenatal alcohol exposure on histaminergic neurons, histidine decarboxylase levels and histamine H receptors in adult rat offspring.

Alcohol 2018 Jul 22;76:47-57. Epub 2018 Jul 22.

Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States. Electronic address:

We have reported that moderate prenatal alcohol exposure (PAE) elevates histamine H receptor-mediated inhibition of glutamatergic neurotransmission in dentate gyrus (DG), and that the H receptor antagonist ABT-239 ameliorates PAE-induced deficits in DG long-term potentiation. Here, we investigated whether PAE alters other markers of histaminergic neurotransmission. Long-Evans rat dams voluntarily consumed either a 0% or a 5% ethanol solution 4 h each day throughout gestation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.007DOI Listing
July 2018
3 Reads

Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats.

Alcohol 2018 Jul 17;76:37-45. Epub 2018 Jul 17.

Department of Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.

Alcohol produces complex effects on the immune system. Moderate alcohol use (1-2 drinks per day) has been shown to produce anti-inflammatory responses in human blood monocytes, whereas, the post mortem brains of severe alcoholics show increased immune gene expression and activated microglial markers. The present study was conducted to evaluate the time course of alcohol effects during exposure and after withdrawal, and to determine the relationship between microglial and cytokine responses in brain and blood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336521PMC
July 2018
3 Reads

The longitudinal effects of military spouses' concern and behaviors over partner drinking on relationship functioning.

Alcohol 2018 Jul 17;76:29-36. Epub 2018 Jul 17.

RAND Corporation, Santa Monica, CA, United States.

Among those in close relationships, the perception that one's partner has a drinking problem is more strongly related to detriments in relationship quality than are the actual rates of the partner's drinking. The current study extends this work by examining the effects of this perception on relationship functioning longitudinally and whether this association is mediated by changes in how one behaves in response to their partner's drinking. Spouses and partners of military service members who were concerned about their partner's drinking (n = 234) completed a baseline survey and a follow-up assessment five months later. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.004DOI Listing
July 2018
2 Reads

Neurodevelopmental outcomes in individuals with fetal alcohol spectrum disorder (FASD) with and without exposure to neglect: Clinical cohort data from a national FASD diagnostic clinic.

Alcohol 2018 Jun 12;76:23-28. Epub 2018 Jun 12.

School of Health and Society, University of Salford, Salford, England, United Kingdom.

Disentangling the relative developmental impact of prenatal alcohol exposure from postnatal neglect is clinically valuable for informing future service provision. In this study, developmental outcomes across groups are compared in a 'natural experiment'.

Methods: Clinical data from 99 persons with fetal alcohol spectrum disorder (FASD) diagnoses were audited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.06.002DOI Listing
June 2018
1 Read

Minocycline Attenuates Ethanol-induced Cell Death and Microglial Activation in the Developing Spinal Cord.

Alcohol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Lexington VA Health Care System, Research & Development, 1101 Veterans Drive, Lexington, Kentucky 40502, USA. Electronic address:

Developmental exposure to ethanol may cause fetal alcohol spectrum disorders (FASD), and immature central nervous system (CNS) is particularly vulnerable to ethanol. In addition to the developing brain, we previously showed that ethanol also caused neuroapoptosis, microglial activation, and neuroinflammation in the spinal cord. Minocycline is an antibiotic that inhibits microglial activation and alleviates neuroinflammation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183020
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.12.002DOI Listing
December 2018
10 Reads

Sexually divergent changes in select brain proteins and neurosteroid levels after a history of ethanol drinking and intermittent PTSD-like stress exposure in adult C57BL/6J mice.

Alcohol 2018 Dec 6. Epub 2018 Dec 6.

Department of Behavioral Neuroscience, Oregon Health & Sciences University, Portland, OR; VA Portland Health Care System, Portland, OR. Electronic address:

Human studies reported that the number of past-year stressors was positively related to current drinking patterns, including binge drinking. In animal models, exposure to predator odor stress (PS), considered a model of traumatic stress, consistently increased ethanol intake. Recently, we reported that repeated PS significantly increased ethanol intake and had a synergistic interaction with prior binge drinking (binge group) in male but not in female C57BL/6J mice, when compared to mice without prior binge exposure (control group). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183025
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.12.001DOI Listing
December 2018
9 Reads

Cigarette smoking, alcohol consumption, and risk of colorectal cancer in South Korea: A case-control study.

Alcohol 2018 Jun 26;76:15-21. Epub 2018 Jun 26.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea. Electronic address:

The current case-control study comprehensively evaluated the status, quantity, and duration of smoking and alcohol drinking for both men and women, considering the subsites of colorectal cancer. A total of 925 colorectal cancer cases and 2775 controls were included in the analysis. Odds ratios (OR) and 95% confidence intervals (CI) were computed by logistic regression models adjusting for potential confounders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.06.004DOI Listing
June 2018
2 Reads

Re-investigating the effects of chronic smoking on the pathology of alcohol-related human brain damage.

Alcohol 2018 Jul 11;76:11-14. Epub 2018 Jul 11.

Discipline of Pathology, Charles Perkins Centre, The University of Sydney School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

Both pathological and neuroimaging studies have shown that chronic alcohol abuse causes generalized white matter, but limited gray matter, volume loss. Recent neuroimaging studies suggest that tobacco smoking also causes brain atrophy in both alcoholics and neurologically normal individuals. However, a recent pathological study, employing a manual technique to determine regional volumes, found no significant effects of smoking on either global or selected regional gray matter volumes in smokers or smoking alcoholics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.07.001DOI Listing
July 2018
3 Reads

Associations between gastrointestinal humoral factors and pancreatic proteolytic enzymes in alcohol-related versus non-alcohol-related pancreatitis.

Alcohol 2018 Jun 28;76:1-10. Epub 2018 Jun 28.

School of Medicine, University of Auckland, Auckland, New Zealand. Electronic address:

Background: Alcohol-related pancreatitis is common and the gastrointestinal tract plays an important role in the regulation of pancreatic exocrine function. While the relationship between pancreatic proteolytic enzymes and insulin (as well as other pancreatic hormones) has been investigated in detail, little is known about the relationship between pancreatic proteolytic enzymes and gastrointestinal humoral factors. The aim of this study was to study the associations between trypsin, chymotrypsin, and a panel of gastrointestinal humoral factors in patients after an episode of alcohol-related versus non-alcohol-related pancreatitis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173089
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.06.005DOI Listing
June 2018
3 Reads

Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults.

Alcohol 2019 Mar 31;75:89-97. Epub 2018 May 31.

Department of Psychiatry, School of Medicine, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.

Our aim was to analyze metabolite profile changes in serum associated with moderate-to-heavy consumption of alcohol in young adults and to evaluate whether these changes are connected to reduced brain gray matter volumes. These study population consisted of young adults with a 10-year history of moderate-to-heavy alcohol consumption (n = 35) and light-drinking controls (n = 27). We used the targeted liquid chromatography mass spectrometry method to measure concentrations of metabolites in serum, and 3. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173098
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.010DOI Listing
March 2019
11 Reads

The α3β4 nicotinic acetylcholine receptor antagonist 18-Methoxycoronaridine decreases binge-like ethanol consumption in adult C57BL/6J mice.

Alcohol 2018 Nov 26. Epub 2018 Nov 26.

Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania, 16802, United States of America. Electronic address:

Binge alcohol drinking is a health burden in the United States which has an alarming economic impact. Unfortunately, medications available for alcohol abuse have low efficacy or adverse side effects creating a need to evaluate novel therapies. Growing research suggests that 18-Methoxycoronaridine (18-MC), an α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, may be effective at reducing ethanol consumption. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183026
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.11.006DOI Listing
November 2018
10 Reads

In Memoriam: Thomas R. Jerrells Editor Emeritus, Alcohol: An International Biomedical Journal.

Authors:
Todd A Wyatt

Alcohol 2018 Dec;73:89-90

College of Public Health at University of Nebraska Medical Center, Omaha, NE, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.08.002DOI Listing
December 2018
1 Read

Assessment of Interleukin-6 Signaling Effects on Behavioral Changes Associated with Acute Alcohol Intoxication in adult male rats.

Alcohol 2018 Nov 22. Epub 2018 Nov 22.

Developmental Exposure to Alcohol Research Center (DEARC), Behavioral Neuroscience Program, Department of Psychology, Binghamton University-SUNY, Binghamton, NY, 13902-6000. Electronic address:

Recent studies have demonstrated unique brain cytokine signatures associated with acute ethanol intoxication (increased IL-6) and withdrawal (increased IL-1β and TNFα). The purpose of the present studies was to examine the potential functional role of increased central interleukin-6 (IL-6). We utilized two tests of ethanol sensitivity to establish a potential role for IL-6 after high (3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.11.004DOI Listing
November 2018
19 Reads

The impact of low to moderate chronic intermittent ethanol exposure on behavioral endpoints in aged, adult and adolescent rats.

Alcohol 2018 Nov 22. Epub 2018 Nov 22.

Department of Psychological Science, Ball State University.

The average age of the population in the United States and other countries is increasing. Understanding the health consequences in the aged population is critical. Elderly individuals consume ethanol, often at elevated rates, and in some cases in a binge episode. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.11.005DOI Listing
November 2018
3 Reads

Leveraging calcium imaging to illuminate circuit dysfunction in addiction.

Alcohol 2019 Feb 6;74:47-63. Epub 2018 Jun 6.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; The Salk Institute for Biological Sciences, 10010 N Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address:

Alcohol and drug use can dysregulate neural circuit function to produce a wide range of neuropsychiatric disorders, including addiction. To understand the neural circuit computations that mediate behavior, and how substances of abuse may transform them, we must first be able to observe the activity of circuits. While many techniques have been utilized to measure activity in specific brain regions, these regions are made up of heterogeneous sub-populations, and assessing activity from neuronal populations of interest has been an ongoing challenge. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183008
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.013DOI Listing
February 2019
12 Reads

Suppressing effect of CMPPE, a new positive allosteric modulator of the GABA receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats.

Alcohol 2019 Mar 31;75:79-87. Epub 2018 May 31.

Neuroscience Institute, Section of Cagliari, National Research Council of Italy, I-09042 Monserrato, CA, Italy. Electronic address:

Positive allosteric modulators (PAMs) of the GABA receptor constitute a class of pharmacological agents gaining increasing attention in the alcohol research field because of their ability to suppress several alcohol-related behaviors in rodents. CMPPE is a novel GABA PAM, still limitedly characterized in vivo. It was therefore of interest to test its ability to affect operant, oral self-administration of alcohol and cue-induced reinstatement of alcohol seeking in alcohol-preferring rats. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183008
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.015DOI Listing
March 2019
11 Reads

Effects of noncontingent ethanol, DHEA, and pregnanolone administration on ethanol self-administration in outbred female rats.

Alcohol 2019 Mar 9;75:67-77. Epub 2018 May 9.

Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States; Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States.

Previous research from this laboratory demonstrated that male outbred rats (Long-Evans) can be trained to prefer ethanol (10% v/v) over water during 30-min home-cage sessions and that higher ethanol concentrations (18-32% v/v) can serve as a reinforcer under various operant schedules. Further, we have shown that two neurosteroids, dehydroepiandrosterone (DHEA) and pregnanolone, can readily decrease ethanol self-administration in males. The present study used the same procedures in an attempt to systematically replicate the previous findings in female outbred rats. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329173094
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.003DOI Listing
March 2019
8 Reads

Anti-addictive properties of COR659 - Additional pharmacological evidence and comparison with a series of novel analogues.

Alcohol 2019 Mar 17;75:55-66. Epub 2018 May 17.

Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100, Siena (SI), Italy.

A recent study found that COR659 (methyl 2-[(4-chlorophenyl)carboxamido]-4-ethyl-5-methylthiophene-3-carboxylate) reduced operant alcohol and chocolate self-administration in rats; COR659 also suppressed cue-induced reinstatement of chocolate seeking in rats. COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABA receptor and an action at the cannabinoid CB receptor. The present study investigated whether the reducing effect of COR659 on alcohol and chocolate self-administration was maintained after repeated treatment and if COR659 affected cue-induced reinstatement of alcohol seeking; additionally, it evaluated the ability of 9 structural analogues of COR659 - designed modifying the substituents on the phenylcarboxamido moiety and replacing the thiophene with the pyridine ring - to affect alcohol and chocolate self-administration. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183010
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.05.007DOI Listing
March 2019
14 Reads

Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung.

Alcohol 2018 Nov 13. Epub 2018 Nov 13.

Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY, 40292, USA; University of Louisville Alcohol Research Center, Louisville, KY, 40292. Electronic address:

Introduction: Alcohol use disorders are major risk factors for the development of and susceptibility to acute respiratory distress syndrome. Although these risks of alcohol consumption on the lung are well described, mechanisms by which alcohol abuse promotes acute lung injury are poorly understood. These gaps in our understanding are due, at least in part, to limitations of animal models to recapitulate human alcohol consumption. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07418329183008
Publisher Site
http://dx.doi.org/10.1016/j.alcohol.2018.10.008DOI Listing
November 2018
21 Reads

The use of chemogenetic approaches in alcohol use disorder research and treatment.

Alcohol 2019 Feb 1;74:39-45. Epub 2018 Jun 1.

Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX 77807, United States. Electronic address:

Several novel techniques were developed recently to explore neural circuit mechanisms of neuropsychiatric disorders. These techniques include the Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools, which represent valuable platforms for selective and non-invasive control of neural activity with a high degree of spatial resolution. Among all variants, Gq- and Gi-DREADDs are widely used by neuroscientists to dissect out the circuitry and cellular signals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295360PMC
February 2019
9 Reads

Advances in behavioral animal models of alcohol use disorder.

Alcohol 2019 Feb 1;74:73-82. Epub 2018 Jun 1.

School of Psychological Sciences, Tel Aviv University, 69978 Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, 69978 Tel Aviv, Israel. Electronic address:

Alcohol use disorder (AUD) is a multifaceted neuropsychiatric disease that combines behavioral, psychosocial, and neurobiological aspects. Over the previous decade, animal models have advanced in modeling the major psychological constructs that characterize AUD. These advances pave the road for more sophisticated behavioral models that capture addiction-related aspects, such as alcohol craving, compulsive seeking and intake, dependence, and relapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alcohol.2018.05.014DOI Listing
February 2019
10 Reads