3,852 results match your criteria Albright Syndrome


A propensity score matched comparison of intracorporeal and extracorporeal techniques for robotic-assisted sigmoidectomy in an enhanced recovery pathway.

J Robot Surg 2018 Dec 10. Epub 2018 Dec 10.

Division of Colon and Rectal Surgery, St. Joseph Mercy Hospital, Ann Arbor, 5325 Elliott Dr., Suite #104, Ann Arbor, MI, 48106, USA.

Intracorporeal options for sigmoid resection have been recently developed but not extensively evaluated. This study was designed to assess outcomes comparing intracorporeal and extracorporeal techniques for robotic-assisted sigmoid resection in an established enhanced recovery pathway. This is a retrospective comparison of intracorporeal and extracorporeal techniques for robotic-assisted sigmoid resection for benign and malignant disease. Read More

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December 2018

Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.

J Endocrinol 2019 Feb;240(2):R21-R45

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.

While 95% of pituitary adenomas arise sporadically without a known inheritable predisposing mutation, in about 5% of the cases they can arise in a familial setting, either isolated (familial isolated pituitary adenoma or FIPA) or as part of a syndrome. FIPA is caused, in 15-30% of all kindreds, by inactivating mutations in the AIP gene, encoding a co-chaperone with a vast array of interacting partners and causing most commonly growth hormone excess. While the mechanisms linking AIP with pituitary tumorigenesis have not been fully understood, they are likely to involve several pathways, including the cAMP-dependent protein kinase A pathway via defective G inhibitory protein signalling or altered interaction with phosphodiesterases. Read More

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February 2019

Remission from chronic opioid use-Studying environmental and socio-economic factors on recovery (RECOVER): Study design and participant characteristics.

Contemp Clin Trials 2018 Nov 30;76:93-103. Epub 2018 Nov 30.

Indivior Inc., 10710 Midlothian Turnpike, Suite 430, Richmond, VA 23235, United States. Electronic address:

Few opioid use disorder (OUD) treatment studies measure meaningful life changes during long-term recovery, focusing instead on retention and abstinence. Here, we report on the design and participant characteristics of the RECOVER study, a study exploring life changes in persons with OUD for up to 24 months following participation in a Phase III trial evaluating buprenorphine extended-release monthly injection for subcutaneous use (known as RBP-6000 during development). This multisite, observational, cohort study tracks clinical, environmental, and socio-economic changes using self-administered assessments, urine drug screens (UDS), and public databases. Read More

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November 2018
1 Read

Making Strides in Type 2 Diabetes Prevention.

Authors:
Ann L Albright

Diabetes Spectr 2018 Nov;31(4):299-302

Director, Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA.

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November 2018

Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden.

J Bone Miner Res 2018 Nov 29. Epub 2018 Nov 29.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Fibrous dysplasia of bone (FD) is a mosaic disease caused by mutations in GNAS. Constitutive activation of the α-subunit of the G stimulatory protein (Gαs) leads to dysregulated proliferation of bone marrow stromal cells (BMSCs), generating expansile lesions of fibrotic tissue and abnormal bone. Local bone remodeling regulation by BMSCs is also altered, and FD tissue is characterized by abundant osteoclast-like cells that may be essential for lesion expansion. Read More

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November 2018
4 Reads

Brief Report: Sex Differences in ASD Diagnosis-A Brief Report on Restricted Interests and Repetitive Behaviors.

J Autism Dev Disord 2018 Nov 28. Epub 2018 Nov 28.

Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

Previous research found repetitive and restricted behaviors (RRBs) were less predictive of Autism Spectrum Disorder (ASD) in females, indicating the diagnostic construct may not adequately describe RRB presentations in females. This mixed-methods study investigated the female presentation of RRBs, namely restricted interests, in a clinic sample of 125 participants (n = 40 female; ages 2-83 years; 75 ASD). RRB severity did not differ between sexes, t = 1. Read More

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November 2018

Fibrous dysplasia for radiologists: beyond ground glass bone matrix.

Insights Imaging 2018 Dec 27;9(6):1035-1056. Epub 2018 Nov 27.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive Room 228 MSC 4320, Bethesda, MD, 20892, USA.

Fibrous dysplasia (FD) is a congenital disorder arising from sporadic mutation of the α-subunit of the Gs stimulatory protein. Osseous changes are characterised by the replacement and distortion of normal bone with poorly organised, structurally unsound, fibrous tissue. The disease process may be localised to a single or multiple bones. Read More

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December 2018
1 Read

[McCune-Albright syndrome with hyperthyroidism: report of one case and review of literature].

Shanghai Kou Qiang Yi Xue 2018 Aug;27(4):445-448

Department of Stomatology, Central Hospital of Xuzhou City. Xuzhou 221009, Jiangsu Province, China.

McCune-Albright Syndrome(MAS) is a rare disease characterized by triad of polyostotic fibrous dysplasia of bone(FD), precocious puberty, and café-au-lait skin pigmentation. This paper reported a case of McCune-Albright syndrome with hyperthyroidism, and discussed the pathogenesis, clinical manifestations, diagnosis and treatment of MAS. Read More

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August 2018
2 Reads

Management of precocious puberty in girls with McCune-Albright syndrome using letrozole.

Authors:
Xi Wang Qi Yu

Endocr Connect 2018 Nov 1. Epub 2018 Nov 1.

Q Yu, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Objective: To evaluate the safety and efficacy of letrozole in girls with progressive precocious puberty (PP) associated with McCune-Albright syndrome (MAS).

Design: Monocentric retrospective cross-sectional and longitudinal study of consecutive patients.

Patients: Ten MAS patients treated at Peking Union Medical College Hospital between September 1999 and December 2017 were retrospectively reviewed; those with complications due to PP were followed. Read More

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November 2018
1 Read

Clinical and Translational Pharmacological Aspects of the Management of Fibrous Dysplasia of Bone.

Br J Clin Pharmacol 2018 Nov 24. Epub 2018 Nov 24.

Department of Medicine, Division of Endocrinology & Centre for Bone Quality, Leiden University Medical Center, Leiden, the Netherlands.

Fibrous dysplasia (FD) is a genetic, non-inheritable rare bone disease caused by a post-zygotic activating mutation of the alpha subunit of the stimulatory G-protein (Gαs) causing increased abnormal bone formation leading to pain, deformity and fractures. To date, no cure has been identified for FD/MAS and treatment is symptomatic and aimed at decreasing pain and/or local bone turnover. Various drugs have been used to achieve clinical improvement in FD/MAS patients including bisphosphonates and denosumab, however further translational studies are also warranted to address unresolved pathophysiological issues and explore novel pharmacological targets for the management of FD/MAS. Read More

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November 2018
4 Reads

ASO Author Reflections: Nipple-Sparing Mastectomy and Treatment Delay.

Ann Surg Oncol 2018 Nov 21. Epub 2018 Nov 21.

University of Iowa, Iowa, IA, USA.

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November 2018

A man with facial disfigurement.

Pan Afr Med J 2018;30:196. Epub 2018 Jul 5.

Excellence Center in Diabetes, Hormones and Metabolism, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

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July 2018
1 Read

Phenotypic testicular abnormalities and pubertal development in boys with McCune-Albright syndrome.

Ital J Pediatr 2018 Nov 19;44(1):136. Epub 2018 Nov 19.

Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.

Aim of this survey is to review the few available literature data on pathophysiologic and clinical aspects of pubertal development in boys with McCune-Albright syndrome (MAS). On the basis of such analysis, we concluded that:1) peripheral precocious puberty (PPP) is significantly more infrequent in boys than in girls; 2) the most common testicular abnormality at MAS presentation is macroorchidism, that may be either monolateral or bilateral; 3) macroorchidism is not always associated with clinical and biochemical evidence of PPP; 4) testicular microlothiasis is distinctly more frequent in boys with MAS than in those without MAS; 5) the available therapeutic schedules have to be adopted already at MAS presentation only in the cases with PPP. Read More

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November 2018
1 Read

Death and Postoperative Complications After Hip Fracture Repair: Dialysis Effect.

Kidney Int Rep 2018 Nov 7;3(6):1294-1303. Epub 2018 Jul 7.

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: It is unknown whether patients receiving dialysis have a higher morbidity and mortality risk after hip fracture repair conferred by their kidney failure or by the high comorbidity burden often present.

Methods: We examined associations of dialysis dependency with postoperative complications, death, and readmission in a matched cohort study of U.S. Read More

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November 2018
6 Reads

Using Digital Droplet Polymerase Chain Reaction to Detect the Mosaic GNAS Mutations in Whole Blood DNA or Circulating Cell-Free DNA in Fibrous Dysplasia and McCune-Albright Syndrome.

J Pediatr 2018 Nov 13. Epub 2018 Nov 13.

Aix Marseille Univ, APHM, INSERM, MMG, Hôpital de la Conception, Laboratory of Molecular Biology, Marseille, France.

The GNAS postzygotic mosaic activating mutations involved in fibrous dysplasia and McCune-Albright syndrome (MAS) are not detectable in leukocytes by Sanger sequencing. Digital droplet polymerase chain reaction detects GNAS mutations in 7 of 12 patients (58.3%) suspected to have fibrous dysplasia/MAS from whole blood DNA, and in 4 of 5 patients (80%) from circulating cell-free DNA. Read More

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November 2018
9 Reads

Pediatric and adolescent injury in rodeo.

Res Sports Med 2018 ;26(sup1):114-128

a Department of Orthopedic Surgery , University of Colorado School of Medicine , Aurora , USA.

High injury potential in rodeo is well recognized but the injury data for pediatric and adolescent rodeo athletes remain sparse. A systematic review of the literature published between 1990 and 2017 was conducted to assess the incidence and determinants of rodeo-related injuries in this population and to suggest injury prevention measures. Three of the 10 included studies reported event frequency and exposure data while the other seven pertained to particular injuries and/or rodeo events. Read More

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January 2018
1 Read

A Regional and National Database Comparison of Colorectal Outcomes.

JSLS 2018 Oct-Dec;22(4)

Department of Surgery, St Joseph Mercy Ann Arbor, Ypsilanti, Michigan, USA.

Background And Objectives: The traditional open approach is still a common option for colectomy and the most common option chosen for rectal resections for cancer. Randomized trials and large database studies have reported the merits of the minimally invasive approach, while studies comparing laparoscopic and robotic options have reported inconsistent results.

Methods: This study was designed to compare open, laparoscopic, and robotic colorectal surgery outcomes in protocol-driven regional and national databases. Read More

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November 2018
4 Reads

Resurgence of Diabetes-Related Nontraumatic Lower Extremity Amputation in the Young and Middle-Aged Adult U.S. Population.

Diabetes Care 2018 Nov 8. Epub 2018 Nov 8.

Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA

Objectives: To determine whether declining trends in lower extremity amputations have continued into the current decade.

Research Design And Methods: We calculated hospitalization rates for nontraumatic lower extremity amputation (NLEA) for the years 2000-2015 using nationally representative, serial cross-sectional data from the Nationwide Inpatient Sample on NLEA procedures and from the National Health Interview Survey for estimates of the populations with and without diabetes.

Results: Age-adjusted NLEA rates per 1,000 adults with diabetes decreased 43% between 2000 (5. Read More

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November 2018
1 Read

Decomposition responses to climate depend on microbial community composition.

Proc Natl Acad Sci U S A 2018 Nov 5;115(47):11994-11999. Epub 2018 Nov 5.

Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697.

Bacteria and fungi drive decomposition, a fundamental process in the carbon cycle, yet the importance of microbial community composition for decomposition remains elusive. Here, we used an 18-month reciprocal transplant experiment along a climate gradient in Southern California to disentangle the effects of the microbial community versus the environment on decomposition. Specifically, we tested whether the decomposition response to climate change depends on the microbial community. Read More

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November 2018
27 Reads

Assessing risk of opioid misuse in the treatment of chronic pain: Building a practical actuarial approach.

J Opioid Manag 2018 Sep/Oct;14(5):381-391

Undergraduate Student, Department of Psychology, Brigham Young University, Provo, Utah.

Objective: Opioid misuse risk assessment has been highlighted as an important part of clinical practice, but there is a paucity of research identifying an effective approach to assessment. Currently, practitioners use patient history, interviews, and formal questionnaires, and these data are weighed clinically to assign risk. The authors propose the use of an actuarial method-the Bayesian nomogram-as a simple, standard, evidence-based approach to opioid misuse risk assessment. Read More

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November 2018
5 Reads

EFFICACY AND SAFETY OF BISPHOSPHONATE THERAPY IN MCCUNE-ALBRIGHT SYNDROME RELATED POLYOSTOTIC FIBROUS DYSPLASIA: A SINGLE-CENTER EXPERIENCE.

Endocr Pract 2018 Nov 1. Epub 2018 Nov 1.

From: Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of Health, Peking Union Medical Collage Hospital, Chinese Academy of Medical Science; Shuaifuyuan No.1, Dongcheng District, Beijing 100730, China.

Objective: Fibrous dysplasia (FD) is a rare disorder characterized by pain, deformity, and pathological fractures. McCune-Albright syndrome (MAS) includes a combination of FD, hyperfunctional endocrinopathy, and/or café-au-lait pigmentation. Surgery is generally ineffective in treating FD. Read More

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November 2018
6 Reads

Regulation of anti-Müllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility.

Asian J Androl 2018 Oct 26. Epub 2018 Oct 26.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

Anti-Müllerian hormone (AMH) is a functional marker of fetal Sertoli cells. The germ cell number in adults depends on the number of Sertoli cells produced during perinatal development. Recently, AMH has received increasing attention in research of disorders related to male fertility. Read More

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October 2018
6 Reads

Fibrous dysplasia of the jaws: Integrating molecular pathogenesis with clinical, radiological, and histopathological features.

J Oral Pathol Med 2018 Oct 30. Epub 2018 Oct 30.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Fibrous dysplasia is a non-neoplastic developmental process that affects the craniofacial bones, characterized by painless enlargement as a result of bone substitution by abnormal fibrous tissue. Postzygotic somatic activating mutations in the GNAS1 gene cause fibrous dysplasia and have been extensively investigated, as well as being helpful in the differential diagnosis of the disease. Fibrous dysplasia may involve one (monostotic) or multiple bones (polyostotic), sporadically or in association with McCune-Albright syndrome, Jeffe-Lichenstein syndrome, or Mazabreud syndrome. Read More

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October 2018
4 Reads

Factors that Influence Sexual and Reproductive Health Information Offered to Adolescents with Perinatally Acquired HIV: An Ecological Analysis of Provider Perspectives.

J Assoc Nurses AIDS Care 2018 Nov - Dec;29(6):822-834. Epub 2018 Jun 12.

The goal of our project was to examine health and social service provider views of factors that influence the nature and timing of sexual and reproductive health (SRH) information shared with adolescents with perinatally acquired HIV (PHIV). Health care (n = 6) and social service (n = 7) providers (11.6 mean years caring for adolescents with PHIV) completed audio-recorded interviews that were transcribed, and coded for emerging themes. Read More

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June 2018
2 Reads

Predictors of early mortality and readmissions among dialysis patients undergoing lower extremity amputation.

J Vasc Surg 2018 Nov 28;68(5):1505-1516. Epub 2018 Jun 28.

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minn; Division of Health Care Policy and Research, Mayo Clinic, Rochester, Minn.

Objective: Patients receiving dialysis are at increased risk for lower extremity amputations (LEAs) and postoperative morbidity. Limited studies have examined differences in 30-day outcomes of mortality and health care use after amputation or the preoperative factors that relate to worsened outcomes in dialysis patients. Our objective was to examine dialysis dependency and other preoperative factors associated with readmission or death after LEA. Read More

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November 2018
1 Read

Physical health characteristics of student service members and veterans by sexual orientation.

J Am Coll Health 2018 Oct 26:1-6. Epub 2018 Oct 26.

b School of Social Work , University of Alabama , Tuscaloosa , Alabama , USA.

Objective: Little is known about the health status of the diverse population of student service members and veterans (SSM/V) enrolling in higher education in great numbers. The objective of this study was to explore the differences in physical health characteristics by sexual orientation among a national sample of SSM/V.

Methods: Using secondary data, a series of maximum likelihood (ML) logistic regression models were estimated to explore physical health characteristics by sexual orientation in a sample of SSM/V. Read More

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October 2018
6 Reads

Brachydactyly Mental Retardation Syndrome Diagnosed in Adulthood.

Cureus 2018 Aug 21;10(8):e3169. Epub 2018 Aug 21.

Internal Medicine, Icahn School of Medicine at Mount Sinai/Queens Hospital Center, New York, USA.

Brachydactyly mental retardation syndrome (BDMR) is due to a rare, small chromosomal deletion of 2q37, and manifests with variable signs and symptoms in people who live with it. BDMR could be misdiagnosed as Albright hereditary osteodystrophy (AHO), because it presents with lack of hormone resistance to parathyroid hormone (PTH) and similar skeletal and craniofacial abnormalities; however, BDMR is far rarer and can present with a different phenotype. In some cases, BDMR patients exhibit malformations of the internal organs, which could cause life-threatening health issues. Read More

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August 2018
1 Read

Case report: An infantile lethal form of Albright hereditary osteodystrophy due to a mutation.

Clin Case Rep 2018 Oct 16;6(10):1933-1940. Epub 2018 Aug 16.

Centre de Génétique Humaine Institut de Pathologie et de Génétique Gosselies Belgium.

Germline loss-of-function mutations are associated with multiple phenotypes, depending on the parental origin of the mutant allele. Here, we describe an infantile lethal form of atypical pseudohypoparathyroidism type 1a or 1c with severe Albright's hereditary osteodystrophy phenotype, underlying the extremely variable expressivity of this syndrome. Read More

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October 2018
5 Reads

Functional Surfaces through Controlled Assemblies of Upper Critical Solution Temperature Block and Star Copolymers.

Langmuir 2018 Oct 31. Epub 2018 Oct 31.

Department of Materials Science and Engineering , Texas A&M University , 575 Ross Street , College Station , Texas 77843 , United States.

Endowing surfaces with multiple advanced functionalities, such as temperature-controlled swelling or the triggered release of functional small molecules, is attractive for a large variety of applications ranging from smart textiles to advanced biomedical applications. This Invited Feature Article summarizes recent advances in the development of upper critical solution temperature (UCST) behavior of copolymers in aqueous solutions and compares the fundamental differences between lower critical solution temperature (LCST) and UCST transitions. The effect of polymer chemistry and architecture on UCST transitions is discussed for block copolymer micelles (BCMs) and star polymers in solution and assembled at surfaces. Read More

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October 2018
4.460 Impact Factor

Lacosamide Pharmacokinetics in a Critically Ill Patient During Continuous Renal Replacement Therapy.

J Pharm Pract 2018 Oct 18:897190018803765. Epub 2018 Oct 18.

1 Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.

The objective of this study is to describe the pharmacokinetics of lacosamide in a critically ill adult during continuous venovenous hemofiltration (CVVH). A 78-year-old male developed sepsis and acute kidney injury following cardiac surgery. He was initially treated with intermittent hemodialysis but developed nonconvulsive status epilepticus at the end of the first session and was subsequently initiated on CVVH. Read More

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October 2018

Deep brain stimulation for pediatric dystonia: a meta-analysis with individual participant data.

Dev Med Child Neurol 2019 Jan 15;61(1):49-56. Epub 2018 Oct 15.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada.

Aim: We performed a meta-analysis with individual participant data of deep brain stimulation (DBS) for dystonia in children and young people.

Method: Three databases (PubMed, Embase, and Web of Science) were queried from January 1999 to August 2017 with no language restrictions to identify case studies and cohort studies reporting on pediatric patients (age ≤21y) with dystonia. The primary outcomes were changes in Burke-Fahn-Marsden (BFM) or Barry-Albright Dystonia Scale scores. Read More

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January 2019
18 Reads
3.510 Impact Factor

A new multi-system disorder caused by the Gαs mutation p.F376V.

J Clin Endocrinol Metab 2018 Oct 11. Epub 2018 Oct 11.

Department for Pediatric Endocrinology and Diabetology; Berlin, Germany.

Context: The alpha-subunit of the stimulatory G-protein (Gαs) links numerous receptors to adenylyl cyclase. Gαs, encoded by GNAS, is expressed predominantly from the maternal allele in certain tissues. Thus, maternal heterozygous loss-of-function mutations cause hormonal resistance, as in pseudohypoparathyroidism type Ia, while somatic gain-of-function mutations cause hormone-independent endocrine stimulation, as in McCune-Albright Syndrome. Read More

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October 2018
1 Read

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy.

Science 2018 10;362(6411)

Merck & Co., Kenilworth, NJ 07033, USA.

Programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) checkpoint blockade immunotherapy elicits durable antitumor effects in multiple cancers, yet not all patients respond. We report the evaluation of >300 patient samples across 22 tumor types from four KEYNOTE clinical trials. Tumor mutational burden (TMB) and a T cell-inflamed gene expression profile (GEP) exhibited joint predictive utility in identifying responders and nonresponders to the PD-1 antibody pembrolizumab. Read More

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October 2018
9 Reads
31.480 Impact Factor

Describing the Use of Animals in Animal-Assisted Intervention Research.

J Appl Anim Welf Sci 2018 Oct 8:1-13. Epub 2018 Oct 8.

c Department of Biomedical and Diagnostic Services , The University of Tennessee College of Veterinary Medicine , Knoxville , TN , USA.

Currently, there has been growing attention to animal welfare in animal-assisted interventions (AAI). However, there is a lack of scrutiny regarding what steps to take to ensure animal wellbeing during AAI research. The Institutional Animal Care and Use Committee (IACUC) reviews, monitors, and approves all research involving animal subjects in order to ensure an animal's ethical and humane treatment. Read More

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October 2018

Racial differences in recurrent ischemic stroke risk and recurrent stroke case fatality.

Neurology 2018 Nov 3;91(19):e1741-e1750. Epub 2018 Oct 3.

From the Departments of Epidemiology (K.C.A., L.H., P.M., V.H.), Health Care Organization and Policy (J.B.), Biostatistics (G.H.), and Medicine (V.B.), University of Alabama at Birmingham; Geriatric Research, Education and Clinical Center (K.C.A.), Birmingham VA Medical Center, AL; and Department of Neurology (M.M.), University of Pennsylvania, Philadelphia.

Objective: To determine black-white differences in 1-year recurrent stroke and 30-day case fatality after a recurrent stroke in older US adults.

Methods: We conducted a retrospective cohort study using a 5% random sample of Medicare beneficiaries with fee-for-service health insurance coverage who were hospitalized for ischemic stroke between 1999 and 2013. Hazard ratios for recurrent ischemic stroke and risk ratios for 30-day case fatality comparing blacks to whites were calculated with adjustment for demographics, risk factors, and competing risk of death when appropriate. Read More

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November 2018
2 Reads

Calciphylaxis in Patients With Preserved Renal Function: Worrisome Wounds.

Mayo Clin Proc 2018 Sep;93(9):1164-1166

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. Electronic address:

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September 2018
1 Read

Liposomal Bupivacaine Transversus Abdominis Plane Block Versus Epidural Analgesia in a Colon and Rectal Surgery Enhanced Recovery Pathway: A Randomized Clinical Trial.

Dis Colon Rectum 2018 Oct;61(10):1196-1204

Division of Colon and Rectal Surgery, St Joseph Mercy Hospital, Ann Arbor, Michigan.

Background: Multimodal pain management is an integral part of enhanced recovery pathways. The most effective pain management strategies have not been determined.

Objective: The purpose of this study was to compare liposomal bupivacaine transversus abdominis plane block with epidural analgesia in patients undergoing colorectal surgery. Read More

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October 2018
5 Reads

The Global Partnership for Education: forging a stronger partnership between health and education sectors to achieve the Sustainable Development Goals.

Lancet Child Adolesc Health 2018 Jul 25;2(7):473-474. Epub 2018 May 25.

London School of Hygiene and Tropical Medicine, London, UK.

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Complications after discharge predict readmission after colorectal surgery.

Surg Endosc 2018 Aug 27. Epub 2018 Aug 27.

Division of Colon and Rectal Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Background: Health care providers, hospitals, and pay-for-performance programs are focused on strategies identifying patients at highest risk for re-admission after colorectal surgery. The study objective was to determine characteristics most associated with re-admission after elective colorectal surgery using a conceptual framework approach.

Methods: This is an observational study of Michigan Surgical Quality Collaborative clinical registry data for 8962 colorectal surgery cases between July-2012 and April-2015. Read More

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Short stature and growth hormone deficiency: unexpected manifestations of McCune-Albright syndrome.

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Department of Radiology, Princess Marina Hospital, Gaborone, Botswana.

McCune-Albright syndrome (MAS) is a rare disease characterised by triad of monostotic or polyostotic fibrous dysplasia, café au-lait skin spots and a variety of endocrine disorders; precocious puberty (PP) being the most common presenting symptom in female patients. Hyperfunction endocrinopathies including hyperthyroidism, growth hormone excess and cortisol excess are typical presentations in MAS. We present a case of 21-year-old woman with clinical and radiological characteristics of MAS triad; she presented with short stature which was attributed to both growth hormone deficiency and PP. Read More

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August 2018
8 Reads

Enhancing Educator Engagement in School Mental Health Care Through Digital Simulation Professional Development.

J Sch Health 2018 Sep;88(9):651-659

Department of Prevention and Community Health, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave., Washington, DC 20052.

Background: Despite the critical role of educators as gatekeepers for school mental health services, they receive limited training to support student mental health. We report findings from a trial of an online mental health role-play simulation for elementary school teachers on changes in attitudes and self-reported helping behaviors for students experiencing psychological distress.

Methods: We randomly assigned 18,896 elementary school teachers to wait-list control or intervention conditions in which they received the 45- to 90-minute online role-play simulation. Read More

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September 2018
1 Read

Trends and Disparities in Cardiovascular Mortality Among U.S. Adults With and Without Self-Reported Diabetes, 1988-2015.

Diabetes Care 2018 Nov 21;41(11):2306-2315. Epub 2018 Aug 21.

Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

Objective: Cardiovascular disease (CVD) mortality has declined substantially in the U.S. The aims of this study were to examine trends and demographic disparities in mortality due to CVD and CVD subtypes among adults with and without self-reported diabetes. Read More

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November 2018

Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome.

J Clin Endocrinol Metab 2018 Nov;103(11):4293-4303

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.

Context: McCune-Albright syndrome (MAS) is a rare disorder characterized by fibrous dysplasia of bone, café-au-lait macules, and hyperfunctioning endocrinopathies. It arises from somatic gain-of-function mutations in GNAS, which encodes the cAMP-regulating protein Gαs. Somatic GNAS mutations have been reported in intraductal papillary mucinous neoplasms (IPMNs) and various gastrointestinal (GI) tumors. Read More

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November 2018
4 Reads

Delivering problem-solving therapy to family caregivers of people with cancer: A feasibility study in outpatient palliative care.

Psychooncology 2018 Oct 31;27(10):2494-2499. Epub 2018 Aug 31.

Department of Family and Community Medicine, University of Missouri, Columbia, Missouri.

Objective: In response to the well-documented need for evidence-based cancer caregiver support, we examined the feasibility of problem-solving therapy for family caregivers of cancer patients receiving outpatient palliative care and investigated the impact of problem-solving therapy on family caregivers' anxiety, depression, and quality of life.

Methods: We conducted a feasibility study of a structured problem-solving therapy intervention delivered to family caregivers of cancer patients receiving outpatient palliative care from an academic health center in the Midwestern United States. Participants (N = 83) were randomly assigned to receive usual care or usual care plus a problem-solving therapy intervention, which was delivered over three sessions via web-based videoconferencing or telephone. Read More

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October 2018

Comparative Genomics of Nitrogen Cycling Pathways in Bacteria and Archaea.

Microb Ecol 2018 Aug 13. Epub 2018 Aug 13.

Bioscience Division, Los Alamos National Laboratory, Mail Stop M888, P.O. Box 1663, Los Alamos, NM, 87545, USA.

Despite the explosion of metagenomic sequencing data, using -omics data to predict environmental biogeochemistry remains a challenge. One or a few genes (referred to as marker genes) in a metabolic pathway of interest in meta-omic data are typically used to represent the prevalence of a biogeochemical reaction. This approach often fails to demonstrate a consistent relationship between gene abundance and an ecosystem process rate. Read More

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August 2018
4 Reads

Combined Femoral-Sciatic Nerve Block is Superior to Continuous Femoral Nerve Block During Anterior Cruciate Ligament Reconstruction in the Pediatric Population.

Iowa Orthop J 2018 ;38:101-106

Department of Orthopaedics Children's Hospital Colorado

Background: Despite advancements in minimally invasive arthroscopic surgical techniques, post-operative pain management following ACL reconstruction remains a concern. This study compares the effectiveness of two common intraoperative pain management strategies - a femoral nerve catheter (FC) versus a combined femoral nerve catheter and single injection sciatic nerve block (FSB) - in pediatric patients undergoing ACL reconstruction.

Methods: The medical records of patients age 8 to 18 who underwent ACL reconstruction at our institution were reviewed retrospectively. Read More

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January 2018
1 Read

The Social Structure of Mortgage Discrimination.

Hous Stud 2018 3;33(5):759-776. Epub 2017 Nov 3.

Princeton University, Office of Population Research, 239 Wallace Hall, Princeton, NJ 08544, 609-258-4949.

In the decade leading up to the U.S. housing crisis, black and Latino borrowers disproportionately received high-cost, high-risk mortgages-a lending disparity well documented by prior quantitative studies. Read More

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November 2017
8 Reads