2,215 results match your criteria Albright Syndrome


Polyostotic Fibrous Dysplasia Mimicking Bone Involvement in Hodgkin Lymphoma: A Pediatric Case and Literature Review.

Acta Haematol 2020 Jul 24:1-5. Epub 2020 Jul 24.

Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy,

Bone involvement in Hodgkin lymphoma (HL) is rare. The differential diagnosis between HL bone localization and other malignant or benign skeletal diseases is challenging. We report the case of a girl affected by classic HL, initially staged IVA because of supradiaphragmatic lymph nodes and skeletal involvement. Read More

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http://dx.doi.org/10.1159/000508261DOI Listing

Metyrapone as treatment in the neonatal McCune-Albright syndrome.

J Pediatr Endocrinol Metab 2020 Jul 22. Epub 2020 Jul 22.

Neonatal Research Group, Health Research Institute La Fe, University and Polytechnic Hospital La Fe, Valencia, Spain.

Objectives To present a case report of succesfully metyrapone treatment of a neonatal patient with McCune-Albrigth syndrome (MAS), a rare disease caused by a genetically mosaic disorder and is characterized by variable hyperfunctional endocrinopathies, bone dysplasia, and café-au-lait spots. Case presentation A preterm newborn was admitted to hospital and she presented difficulty controlling hypertension, café-au-lait spots, and failure to thrive. An abdominal ultrasound and a magnetic resonance showed a high volume of both suprarenal glands. Read More

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http://dx.doi.org/10.1515/jpem-2020-0036DOI Listing

Organized Hematoma of the Sphenoid Sinus With Acute Blindness: Insight Into Pathogenesis of Disease.

Ear Nose Throat J 2020 Jul 20:145561320941959. Epub 2020 Jul 20.

Atlantic NeuroSurgical Specialists, Morristown Medical Center, Morristown, NJ, USA.

Sinonasal organized hematomas (OHs) are rare lesions that primarily localize to the maxillary sinus. The rate of growth of these masses has not been described in the literature. We present a case of a 59-year-old gentleman with polyostotic fibrous dysplasia who presented with acute loss of vision in the left eye from an expanding OH of the sphenoid sinusitis. Read More

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http://dx.doi.org/10.1177/0145561320941959DOI Listing

Impaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS.

Sci Rep 2020 Jul 9;10(1):11389. Epub 2020 Jul 9.

Department of Biochemistry, CARIM, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.

Patients diagnosed with pseudohypoparathyroidism type Ia (PHP Ia) suffer from hormonal resistance and abnormal postural features, in a condition classified as Albright hereditary osteodystrophy (AHO) syndrome. This syndrome is linked to a maternally inherited mutation in the GNAS complex locus, encoding for the GTPase subunit Gsα. Here, we investigated how platelet phenotype and omics analysis can assist in the often difficult diagnosis. Read More

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http://dx.doi.org/10.1038/s41598-020-68379-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347634PMC

Natural History and Progression of Craniofacial Fibrous Dysplasia: A Retrospective Evaluation of 114 Patients From Massachusetts General Hospital.

J Oral Maxillofac Surg 2020 May 30. Epub 2020 May 30.

Walter C. Guralnick Distinguished Professor and Chief, Emeritus, Department of Oral & Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA. Electronic address:

Purpose: The natural history of fibrous dysplasia (FD) is poorly understood. The purpose of this study was to identify differences in demographic, clinical, and radiographic characteristics among patients with craniofacial FD, including McCune-Albright syndrome (MAS), polyostotic fibrous dysplasia (PFD), and monostotic fibrous dysplasia (MFD). We hypothesized that patients with MAS would show higher disease severity, have more complications, and undergo more operations than those with PFD or MFD. Read More

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http://dx.doi.org/10.1016/j.joms.2020.05.036DOI Listing

Bilateral Dysplastic Gangliocytoma with Concurrent Polyostotic Fibrous Dysplasia: A Case Report and Literature Review.

World Neurosurg 2020 Jun 16;141:421-424. Epub 2020 Jun 16.

Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China; Institute of Neurology, Lanzhou University, Lanzhou, Gansu, China. Electronic address:

Background: Dysplastic gangliocytoma is a sporadic cerebellar benign tumor with the characteristics of hamartoma and true tumor, also known as Lhermitte-Duclos disease (LDD). Bone fibrous dysplasia (FD) is a slowly progressive self-limited benign bone tissue disease. Cowden syndrome, an autosomal dominant genetic disorder caused by germline mutations in the PTEN gene, is considered to be closely related to dysplastic gangliocytoma. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.071DOI Listing

A 5-year-old girl with tall stature and painless vaginal bleeding.

Paediatr Child Health 2020 Jun 13;25(4):203-204. Epub 2019 Apr 13.

Department of Pediatrics, IWK Health Centre, Halifax, Nova Scotia.

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http://dx.doi.org/10.1093/pch/pxz029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286738PMC

Pathological Fracture of the Tibia in a Monostotic Anterior Cortical Fibrous Dysplasia: Hybrid Fixation with UnicorticalOsteoperiosteal Non-Vascularized Fibula Graft - A Case Report.

J Orthop Case Rep 2020 ;9(6):19-22

Department of Orthopaedic Surgery, Sir J.J. Group of Hospitals and Grant Medical College, Mumbai, Maharashtra, India.

Introduction: Fibrous Dysplasia is a relatively rare Musculoskeletal disorders in which there is a defect in remodelling of immature bone to mature lamellar bone. Fibrous Dysplasia was first described by Von Recklinghausen in 1891, but it was Lichtenstein who labelled it polyostotic Fibrous Dysplasia in 1938. Union of Pathological Fractures in a bone affected by Fibrous Dysplasia poses a difficult set of Challenges for treating Physicians. Read More

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http://dx.doi.org/10.13107/jocr.2019.v09.i06.1570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276599PMC
January 2020

Hedgehog Activation Regulates Human Osteoblastogenesis.

Stem Cell Reports 2020 Jul 11;15(1):125-139. Epub 2020 Jun 11.

Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8656, Japan; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8655, Japan; Department of Cell Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan. Electronic address:

Two genetic diseases, Gorlin syndrome and McCune-Albright syndrome (MAS), show completely opposite symptoms in terms of bone mineral density and hedgehog (Hh) activity. In this study, we utilized human induced pluripotent stem cell (iPSC)-based models of the two diseases to understand the roles of Hh signaling in osteogenesis. Gorlin syndrome-derived iPSCs showed increased osteoblastogenesis and mineralization with Hh signaling activation and upregulation of a set of transcription factors in an osteogenic culture, compared with the isogenic control. Read More

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http://dx.doi.org/10.1016/j.stemcr.2020.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363748PMC

A Signature of Circulating miRNAs Associated With Fibrous Dysplasia of Bone: the mirDys Study.

J Bone Miner Res 2020 Jun 11. Epub 2020 Jun 11.

Department of Rheumatology, Edouard Herriot University Hospital, Lyon, France.

Fibrous dysplasia (FD) is a rare bone disease caused by activating mutations of GNAS encoding the Gsα protein, enhancing cyclic adenosine monophosphate (cAMP) production by overstimulation of adenylyl cyclase and impairing osteoblastic differentiation. The clinical presentation ranges from asymptomatic to polyostotic forms with severe disability, explained by the mosaic distribution of the GNAS mutation. Physicians have to deal with the gap of knowledge in FD pathogenesis, the absence of prognostic markers and the lack of specific treatment. Read More

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http://dx.doi.org/10.1002/jbmr.4111DOI Listing

The Role of Staged Cryosurgery and Three-Dimensional Computed Tomography Integrated Navigation System in the Surgical Management of Severe Involvement of Craniofacial Polyostotic Fibrous Dysplasia.

J Craniofac Surg 2020 Jun;31(4):1006-1009

Plastic, Reconstructive and Aesthetic Surgeon, Private Practice, Kadikoy, Istanbul, Turkey.

Fibrous dysplasia (FD) is a developmental bone disorder caused by the hamartamatous proliferation of bone-forming cells. A 29-year-old male patient with diagnosis of FD was admitted to our clinic with the symptoms of severe craniomaxillofacial involvement of FD beginning from last year. Neurological examination revealed diplopia, horizontal nystagmus, conductive hearing loss, and partial vision loss. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006348DOI Listing

Adrenocortical tumorigenesis: Lessons from genetics.

Best Pract Res Clin Endocrinol Metab 2020 May 23;34(3):101428. Epub 2020 May 23.

Section on Endocrinology and Genetics & Inter-Institute Endocrinology Fellowship Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, 20892, USA. Electronic address:

Advances in genomics over the past two decades have allowed for elucidation of the genetic alterations leading to the development of adrenocortical tumors and/or hyperplasias. These molecular changes were initially discovered through the study of rare familial tumor syndromes such as McCune-Albright Syndrome, Carney complex, Li-Fraumeni syndrome, and Beckwith-Wiedemann syndrome, with the identification of alterations in genes and molecular pathways that subsequently led to the discovery of aberrations in these or related genes and pathways in sporadic tumors. Genetic alterations in GNAS, PRKAR1A, PRKACA, PRKACB, PDE11A, and PDE8B, that lead to aberrant cyclic adenosine monophosphate-protein (cAMP) kinase A signaling, were found to play a major role in the development of benign cortisol-producing adrenocortical tumors and/or hyperplasias, whereas genetic defects in KCNJ5, ATP1A1, ATP2B3, CACNA1D, CACNA1H, and CLCN2 were implicated in the development of benign aldosterone-producing tumors and/or hyperplasias through modification of intracellular calcium signaling. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101428DOI Listing
May 2020
4.602 Impact Factor

New Therapies for Hypophosphatemia-Related to FGF23 Excess.

Calcif Tissue Int 2020 Jun 5. Epub 2020 Jun 5.

Department of Medicine Section of Endocrinology, Yale School of Medicine, PO Box 802080, New Haven, CT, 06520, USA.

FGF23 is a hormone produced by osteocytes in response to an elevation in the concentration of extracellular phosphate. Excess production of FGF23 by bone cells, or rarely by tumors, is the hormonal basis for several musculoskeletal syndromes characterized by hypophosphatemia due to renal phosphate wasting. FGF23-dependent chronic hypophosphatemia causes rickets and osteomalacia, as well as other skeletal complications. Read More

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http://dx.doi.org/10.1007/s00223-020-00705-3DOI Listing

Rare musculoskeletal diseases in adults: a research priority setting partnership with the James Lind Alliance.

Orphanet J Rare Dis 2020 May 19;15(1):117. Epub 2020 May 19.

The Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.

Background: Osteogenesis imperfecta, fibrous dysplasia/McCune-Albright syndrome and X-linked hypophosphatemia are three rare musculoskeletal diseases characterised by bone deformities, frequent fractures and pain. Little high-quality research exists on appropriate treatment and long-term management of these conditions in adults. This is further worsened by limited research funding in rare diseases and a general mismatch between the existing research priorities and those of the patients. Read More

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http://dx.doi.org/10.1186/s13023-020-01398-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238497PMC

McCune Albright Syndrome: Gastrointestinal Polyps and Platelet Dysfunction over 12 Years.

Horm Res Paediatr 2020 8;93(1):40-45. Epub 2020 May 8.

Department of Endocrinology, The Royal Children's Hospital, Parkville, Victoria, Australia.

Background And Objective: Gastrointestinal (GI) polyps with unknown malignant potential and a platelet storage pool deficiency that increases the risk of severe intraoperative and other types of bleeding have been identified in McCune-Albright syndrome (MAS). The natural course of these disorders has not been well characterized. The aim of this study was to report the follow-up of GI polyps and platelet dysfunction (PD) in a cohort of 28 patients with MAS. Read More

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http://dx.doi.org/10.1159/000507442DOI Listing

A rare case of polyostotic fibrous dysplasia detected on F-rhPSMA-7 PET/CT.

Eur J Nucl Med Mol Imaging 2020 Apr 16. Epub 2020 Apr 16.

Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Ismaninger Straße 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1007/s00259-020-04751-9DOI Listing

Clinical and Molecular Update on Genetic Causes of Pituitary Adenomas.

Horm Metab Res 2020 Apr 16. Epub 2020 Apr 16.

Department of Endocrinology, CHU de Liège, Liège Université, Liège, Belgium.

Pituitary adenomas are benign tumors with variable functional characteristics that can have a significant impact on patients. The majority arise sporadically, but an inherited genetic susceptibility is increasingly being recognized. Recent advances in genetics have widened the scope of our understanding of pituitary tumorigenesis. Read More

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http://dx.doi.org/10.1055/a-1143-5930DOI Listing

PET imaging of phosphodiesterase-4 identifies affected dysplastic bone in McCune-Albright syndrome, a genetic mosaic disorder.

J Nucl Med 2020 Apr 13. Epub 2020 Apr 13.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, United States.

McCune-Albright syndrome (MAS) is a mosaic disorder arising from gain-of-function mutations in the GNAS gene, which encodes the 3', 5'-cyclic adenosine monophosphate (cAMP) pathway-associated G-protein, Gsα. Clinical manifestations of MAS in a given individual, including fibrous dysplasia, are determined by the timing and location of the GNAS mutation during embryogenesis, the tissues involved, and the role of Gsα in the affected tissues. The Gsα mutation results in dysregulation of the cAMP signaling cascade, leading to upregulation of phosphodiesterase type 4 (PDE4), which catalyzes the hydrolysis of cAMP. Read More

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http://dx.doi.org/10.2967/jnumed.120.241976DOI Listing

Lower limb lengthening and deformity correction in polyostotic fibrous dysplasia using external fixation and flexible intramedullary nailing.

J Orthop 2020 Sep-Oct;21:192-198. Epub 2020 Mar 28.

Russian Ilizarov Scientific Centre for Restorative Traumatology and Orthopaedics, 6, M. Ulyanova Street, 640014, Kurgan, Russian Federation.

The study describes preliminary experience of the use of external fixators for limb lengthening and deformity correction in combination with flexible intramedullary nailing in management of polyostotic fibrous dysplasia.

Patients And Methods: The retrospective study included 8 patients (mean age 11.6 ± 3. Read More

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http://dx.doi.org/10.1016/j.jor.2020.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125318PMC

Orbital Aneurysmal Bone Cyst in a Patient With McCune-Albright Syndrome.

Ophthalmic Plast Reconstr Surg 2020 Apr 3. Epub 2020 Apr 3.

Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, U.S.A.

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http://dx.doi.org/10.1097/IOP.0000000000001650DOI Listing

Hypophosphataemic Rickets: Similar Phenotype of Different Diseases.

Adv Ther 2020 05 31;37(Suppl 2):80-88. Epub 2020 Mar 31.

Sección de Nefrología Pediátrica, Hospital Universitario La Fe, Valencia, Spain.

Hypophosphataemic rickets (HR) is a group of rare disorders caused by excessive renal phosphate wasting in which the participation of fibroblast growth factor 23 (FGF23) can be prominent. These diseases pose therapeutic challenges with important consequences for growth and bone development in childhood, with higher risk of fractures and poorer bone healing, dental problems, and nephrolithiasis or nephrocalcinosis. In some cases, the diagnostic delay can be very long; laboratory findings and an exhaustive anamnesis could help distinguish between various pathologies, and FGF23 values-although currently not routinely measured-have implications for the differential diagnosis. Read More

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http://dx.doi.org/10.1007/s12325-019-01182-3DOI Listing

[Hereditary predispositions to follicular thyroid tumors].

Ann Pathol 2020 Apr 17;40(2):142-147. Epub 2020 Mar 17.

Service d'anatomie et cytologie pathologique, hospices civils de Lyon, centre hospitalier Lyon-Sud, 165, chemin grand revoyet, 69310 Pierre-Bénite, France; Inserm1052 CNRS5286, centre de recherche en cancérologie de Lyon, université Lyon 1, Lyon, France. Electronic address:

Familial thyroid cancers of follicular origin are rare and include syndromic and non-syndromic tumours. In familial adenomatous polyposis, the prevalence of papillary thyroid cancer is 2-12% and in 20-40% of cases it is a cribriform-morular papillary thyroid carcinoma. Morules and cribriform pattern are the two main typical criteria, associated with a nuclear and cytoplasmic immunopositivity for beta catenin. Read More

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http://dx.doi.org/10.1016/j.annpat.2020.02.011DOI Listing

McCune Albright Syndrome.

Kans J Med 2020 28;13:49-50. Epub 2020 Feb 28.

University of Kansas Medical Center, Department of Internal Medicine, Division of Dermatology, Kansas City, KS.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053411PMC
February 2020

Legius Syndrome and its Relationship with Neurofibromatosis Type 1.

Acta Derm Venereol 2020 Mar;100(7):adv00093

Neurofibromatosis type 1 (NF1) is the most common disorder characterized by multiple café-au-lait macules. Most individuals with this autosomal dominant disorder also have other features, such as skinfold freckling, iris Lisch nodules and benign or malignant peripheral nerve sheath tumours. Legius syndrome is a less frequent autosomal dominant disorder with similar multiple café-au-lait macules and skinfold freckling. Read More

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http://dx.doi.org/10.2340/00015555-3429DOI Listing

DIAGNOSIS OF ENDOCRINE DISEASE: Mosaic disorders of FGF23 excess: Fibrous dysplasia/McCune-Albright syndrome and cutaneous skeletal hypophosphatemia syndrome.

Eur J Endocrinol 2020 May;182(5):R83-R99

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

Fibrous dysplasia/McCune-Albright Syndrome (FD/MAS), arising from gain-of-function mutations in Gαs, and cutaneous skeletal hypophosphatemia syndrome (CSHS), arising from gain-of-function mutations in the Ras/MAPK pathway, are strikingly complex, mosaic diseases with overlapping phenotypes. Both disorders are defined by mosaic skin and bone involvement, and both are complicated by increased FGF23 production. These similarities have frequently led to mis-diagnoses, primarily in patients with CSHS who are often assumed to have FD/MAS. Read More

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http://dx.doi.org/10.1530/EJE-19-0969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104564PMC

Fibro-osseous Lesions of Paranasal Sinus and Craniofacial Region: A Retrospective Study of 282 Cases.

Laryngoscope 2020 Feb 14. Epub 2020 Feb 14.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, U.S.A.

Objectives: To compare the clinical characteristics of osteoma, ossifying fibroma (OF) and fibrous dysplasia (FD) in the paranasal sinus and craniofacial regions.

Methods: Totally 282 patients (112 males, 170 females) with osteoma (161), OF (44), and FD (77) involving the paranasal sinus, skull base and orbit treated surgically from January 2012 to August 2018 were analyzed retrospectively.

Results: For osteoma, OF and FD, the onset ages were 40. Read More

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http://dx.doi.org/10.1002/lary.28529DOI Listing
February 2020

Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome.

Front Endocrinol (Lausanne) 2019 24;10:925. Epub 2020 Jan 24.

Division of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.

The G G-protein coupled receptor pathway is a critical regulator of normal bone formation and function. The G pathway increases intracellular cAMP levels by ultimately acting on adenylate cyclase. McCune-Albright Syndrome (MAS) and fibrous dysplasia (FD) of the bone are two proto-typical conditions that result from increased cellular G signaling activity. Read More

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http://dx.doi.org/10.3389/fendo.2019.00925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993052PMC
January 2020

McCune-Albright syndrome and type 1 diabetes mellitus: a novel presentation.

Ann N Y Acad Sci 2020 03 10;1463(1):5-8. Epub 2020 Feb 10.

Division of Pediatric Endocrinology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

McCune-Albright syndrome (MAS) is caused by postzygotic somatic activating mutations of GNAS and is classically characterized by the clinical triad of peripheral precocious puberty, café-au-lait pigmentation, and polyostotic fibrous dysplasia. It can also present with other hyperfunctioning endocrinopathies, including growth hormone excess, hyperprolactinemia, hypercortisolemia, hyperthyroidism, and renal phosphate wasting due to excess fibroblast growth factor 23. We review the clinical, biochemical, radiological, and genetic findings in a 7-year-old girl diagnosed with MAS at age 4 and then with autoimmune type 1 diabetes mellitus at age 7. Read More

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http://dx.doi.org/10.1111/nyas.14310DOI Listing

A case report of Proteus syndrome (PS).

BMC Med Genet 2020 01 21;21(1):15. Epub 2020 Jan 21.

Department of Endocrinology, ShenZhen Hospital, Southern Medical University, No. 1333, Xinhu Road, Shenzhen, 518100, Guangdong, China.

Background: Proteus syndrome (PS) is an extremely rare disease characterized by excessive chimeric growth of cells, and progressive and irregular asymmetrical hyperplasia.

Case Presentation: Herein, a PS case with atypical clinical features and syndromes was reported, to improve the understanding of the diagnosis and treatment of the disease. The case was a 3-year-and-11-month-old male child. Read More

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http://dx.doi.org/10.1186/s12881-020-0949-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975093PMC
January 2020

Priority of Treatment in Craniofacial Fibrous Dysplasia.

Ann Maxillofac Surg 2019 Jul-Dec;9(2):451-454

Department of Oral and Maxillofacial Surgery, Maharaja Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India.

Fibrous dysplasia (FD) is a nonneoplastic hamartomatous developmental fibro-osseous lesion, with anomaly in bone-forming mesenchyme which manifests as a defect in osteoblastic differentiation and maturation leading to fibro-osseous tissue formation characterized by deformities in the bone, fractures, nerve compression, and bone pain. The clinical behavior and progression of FD make the management of this condition difficult. Here is a case report of a young male patient who was diagnosed as having craniomaxillofacial FD. Read More

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http://dx.doi.org/10.4103/ams.ams_186_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933985PMC
January 2020

The Clinical Spectrum of McCune-Albright Syndrome and Its Management.

Horm Res Paediatr 2019 19;92(6):347-356. Epub 2019 Dec 19.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA,

McCune-Albright syndrome (MAS) is a rare, mosaic disorder presenting along a broad clinical spectrum. Disease arises from somatic-activating GNAS mutations, leading to constitutive Gαs activation and ligand-independent signaling of the Gαs-coupled protein receptor. The phenotype is largely determined by location and extent of tissues in which the GNAS mutation is expressed, as well as the pathophysiologic effects of Gαs activation within these tissues. Read More

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http://dx.doi.org/10.1159/000504802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302983PMC

Development of molecular analysis by digital PCR for clinical practice: positioning, current applications and perspectives.

Ann Biol Clin (Paris) 2019 12;77(6):619-637

ID Solutions, Grabels, France, Service d'anatomie pathologique et neuropathologie, Assistance Publique Hôpitaux de Marseille, AP-HM, Marseille, France.

This review is the second part of the workshop on digital PCR (dPCR) proposed by the working group of the French society of clinical biology. The first part of the paper discusses the advantages and limitations of dPCR for the search of different molecular abnormalities such as point mutations, copy number variants, DNA methylation, RNA analysis and a more innovative application, the single-cell dPCR. This synthesis makes it possible to propose a positioning of the dPCR compared to the other available technologies in a medical laboratory. Read More

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http://dx.doi.org/10.1684/abc.2019.1502DOI Listing
December 2019

McCune Albright syndrome is a genetic predisposition to intraductal papillary and mucinous neoplasms of the pancreas associated pancreatic cancer in relation with GNAS somatic mutation - a case report.

Medicine (Baltimore) 2019 Dec;98(50):e18102

Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité.

Rationale: Intraductal papillary and mucinous neoplasms of the pancreas (IPMN) are preneoplastic lesions diagnosed with an increasing incidence. Recently, several groups have described, in up to 70% of IPMN, activating mutations of the G-protein alpha stimulatory sub-unit (Gsα subunit) gene (GNAS). GNAS-activating somatic, post-zygotic, mutations are also associated with McCune-Albright syndrome (MCAS) characterized by fibrous dysplasia, precocious puberty, and café-au-lait spots. Read More

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http://dx.doi.org/10.1097/MD.0000000000018102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922479PMC
December 2019

Café au Lait Macules and Associated Genetic Syndromes.

Authors:
Sharon Anderson

J Pediatr Health Care 2020 Jan - Feb;34(1):71-81

Café au lait macules (CALMs) are a common, isolated dermatologic finding in the general population. But when do these irregularly shaped, jagged-edged, flat, hyperpigmented birthmarks suggest something that may warrant referral? Most pediatric providers are familiar with the association of CALMs and neurofibromatosis type 1. There are, however, other genetic conditions associated with these seemingly benign skin spots. Read More

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http://dx.doi.org/10.1016/j.pedhc.2019.05.001DOI Listing
December 2018

[Transsphenoid extirpation of pituitary adenomas in patients with McCune-Albright syndrome (two cases from practice and literature review)].

Zh Vopr Neirokhir Im N N Burdenko 2019 ;83(5):58-66

Burdenko Neurosurgical Center, Moscow, Russia.

Introduction: McCune-Albright Syndrome is a rare genetic disease characterized by the formation of fibrous osteodysplasia foci of various localization, including the bones of skull base. Having a gross lesion of the main bone body and the simultaneous formation of the pituitary adenoma, its transnasal removal becomes very difficult.

Material And Methods: Two clinical observations are presented where at patients with the classic manifestation of McCune-Albright syndrome we were able to successfully remove somatotropinomas with endoextrasellar growth. Read More

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http://dx.doi.org/10.17116/neiro20198305158DOI Listing
January 2020

Symptomatic Mandibular Fibrous Dysplasia With Concurrent Triple X- and Premutation Stage Fragile-X-Syndrome: Case Report With Short Literature Survey.

Anticancer Res 2019 Dec;39(12):6769-6780

Institute of Pathology, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.

Background: Certain constitutive chromosomal abnormalities of the human X chromosome are relatively common in conspicuous neuropsychiatric findings. Although tumors or tumor-like lesions are occasionally reported in diseases of the X chromosome, they are numerically negligible, for example, in aneuploidy such as the triple X syndrome (TXS).

Case Report: A 16-year-old female patient with a known TXS and premutation stage of fragile X syndrome was referred by her dentist for diagnosis and treatment of unilateral cheek swelling. Read More

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http://dx.doi.org/10.21873/anticanres.13892DOI Listing
December 2019

Patients With Isolated Craniofacial Dysplasia Report Better Quality of Life Compared With Those With Craniofacial Dysplasia and Extracranial Involvement.

Ophthalmic Plast Reconstr Surg 2020 May/Jun;36(3):292-297

Department of Medicine, Division Endocrinology.

Purpose: Craniofacial fibrous dysplasia (CFD) is a subtype of fibrous dysplasia/McCune-Albright syndrome (FD/MAS) characterized by FD lesions in one or more of the skull bones. The orbit is often involved, with facial pain, facial deformity, and increased risk of compressive optic neuropathy as associated clinical manifestations possibly leading to altered illness perceptions and impairments in quality of life(QoL). The aim of this study was to evaluate illness perceptions and QoL in patients with CFD among our FD/MAS cohort. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001536DOI Listing
December 2019

Co-administration of Systemic and Intralesional Zoledronic Acid in a Case of Fibrous Dysplasia: A Potentially Novel Therapy.

Front Endocrinol (Lausanne) 2019 19;10:803. Epub 2019 Nov 19.

Department of Orthopedics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Fibrous dysplasia (FD) is a benign bone lesion characterized by replacement of normal bone with abnormal fibrous tissue, clinically manifesting as deformities, bone pains, and pathological fractures. The standard medical management for FD includes systemic bisphosphonate therapy. The efficacy of systemic bisphosphonate is however limited with minimal functional improvement and pain relief. Read More

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http://dx.doi.org/10.3389/fendo.2019.00803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877477PMC
November 2019

Presence of aberrant adrenocorticotropic hormone precursors in two cases of McCune-Albright syndrome.

Endocr J 2020 Mar 4;67(3):353-359. Epub 2019 Dec 4.

Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine and Hospital, Hirosaki, Aomori, Japan.

McCune-Albright syndrome (MAS) is a rare disorder. MAS is classically defined by the occurrence of fibrous dysplasia, café-au-lait skin macules, and precocious puberty. In addition to precocious puberty, other hyperfunctioning endocrinopathies may occur. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0449DOI Listing

Insights into pituitary tumorigenesis: from Sanger sequencing to next-generation sequencing and beyond.

Expert Rev Endocrinol Metab 2019 11 2;14(6):399-418. Epub 2019 Dec 2.

Department of Medicine, The University of Melbourne, Parkville, Australia.

: This review explores insights provided by next-generation sequencing (NGS) of pituitary tumors and the clinical implications.: Although syndromic forms account for just 5% of pituitary tumours, past Sanger sequencing studies pragmatically focused on them. These studies identified mutations in and causing Multiple Endocrine Neoplasia-1 (MEN1), MEN4, Carney Complex-1, McCune Albright Syndrome and 3P association syndromes, respectively. Read More

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http://dx.doi.org/10.1080/17446651.2019.1689120DOI Listing
November 2019

Multiple paraspinal intramuscular myxomas: case report.

J Neurosurg Spine 2019 Nov 29:1-4. Epub 2019 Nov 29.

Departments of1Neurosurgery and.

Intramuscular myxomas (IMMs) are rare benign tumors of mesenchymal origin that are most often located in large skeletal muscles, particularly of the thigh. They have also been reported within the paraspinal musculature and should be considered in the differential diagnosis of a paraspinal mass. These lesions can cause neurological symptoms due to mass effect. Read More

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http://dx.doi.org/10.3171/2019.9.SPINE19599DOI Listing
November 2019

Prepubertal Vaginal Bleeding: An Inpatient Series from a Single Center in Fujian China.

J Pediatr Adolesc Gynecol 2020 Apr 22;33(2):120-124. Epub 2019 Nov 22.

Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou, China. Electronic address:

Study Objective: This study characterizes the etiology, clinical features and outcomes of prepubescent vaginal bleeding and summarizes our experience.

Design: The data of patients who were hospitalized with vaginal discharge or bleeding treated from January 2012 to December 2018 were retrospectively reviewed.

Setting: A provincial Grade III Level A Maternity and Children's Hospital. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.11.009DOI Listing
April 2020
1.812 Impact Factor

Correction to: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium.

Orphanet J Rare Dis 2019 Nov 21;14(1):267. Epub 2019 Nov 21.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA.

The original version of this article [1] unfortunately included an error to an author's name. Paul Arundel was inadvertently presented as Paul Arunde. Read More

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http://dx.doi.org/10.1186/s13023-019-1255-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868680PMC
November 2019
3.358 Impact Factor

The surgical management of monostotic fibrous dysplasia of the inferior turbinate.

J Stomatol Oral Maxillofac Surg 2019 Nov 2. Epub 2019 Nov 2.

Division of Maxillofacial Surgery, University of Eastern Piedmont, Novara, Italy.

Fibrous dysplasia is a non-neoplastic, sporadic, slowly progressing disease of the bone in which normal bone is replaced by abnormally overgrowing lesions. There are three different types of fibrous dysplasia: monostotic (affecting a single bone), poliostotic (affecting multiple bones) and syndromic, when it is associated with other diseases (such as McCune Albright syndrome). Fibrous dysplasia affects cranio-facial bones in 10% of the cases. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.10.014DOI Listing
November 2019

Fibrous Dysplasia/McCune-Albright Syndrome: A Rare, Mosaic Disease of Gα s Activation.

Endocr Rev 2020 Apr;41(2)

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.

Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare disorder of striking complexity. It arises from somatic, gain-of-function mutations in GNAS, leading to mosaic Gα s activation and inappropriate production of intracellular cyclic adenosine monophosphate (cAMP). The clinical phenotype is largely determined by the location and extent of affected tissues, and the pathophysiological effects of Gα s activation within these tissues. Read More

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http://dx.doi.org/10.1210/endrev/bnz011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127130PMC
April 2020
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Improved Molecular Diagnosis of McCune-Albright Syndrome and Bone Fibrous Dysplasia by Digital PCR.

Front Genet 2019 18;10:862. Epub 2019 Sep 18.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

McCune-Albright syndrome (MAS) is a rare congenital disorder characterized by the association of endocrine and nonendocrine anomalies caused by somatic activating variants of . The mosaic state of variants makes the clinical presentation extremely heterogeneous depending on involved tissues. Biological samples bearing a low level of mosaicism frequently lead to false-negative results with an underestimation of causative molecular alterations, and the analysis of biopsies is often needed to obtain a molecular diagnosis. Read More

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http://dx.doi.org/10.3389/fgene.2019.00862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760069PMC
September 2019
1 Read

Genetics of Pituitary Tumours.

Exp Suppl 2019 ;111:171-211

Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Pituitary tumours are relatively common in the general population. Most often they occur sporadically, with somatic mutations accounting for a significant minority of somatotroph and corticotroph adenomas. Pituitary tumours can also develop secondary to germline mutations as part of a complex syndrome or as familial isolated pituitary adenomas. Read More

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http://dx.doi.org/10.1007/978-3-030-25905-1_10DOI Listing
October 2019
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Overview of Genetically Determined Diseases/Multiple Endocrine Neoplasia Syndromes Predisposing to Endocrine Tumors.

Exp Suppl 2019 ;111:105-127

2nd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

In this chapter, we present an overview of multiple endocrine neoplasia syndromes including their most important clinical and molecular features. Multiple endocrine neoplasia type 1 and 2 syndromes (MEN1 and MEN2) are discussed in detail. Syndromes that are presented in other chapters are only briefly mentioned. Read More

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http://dx.doi.org/10.1007/978-3-030-25905-1_7DOI Listing
October 2019
1 Read

Unusual Presentation of Fibrous Dysplasia in an Elderly Patient.

J Radiol Case Rep 2019 Feb 28;13(2):26-33. Epub 2019 Feb 28.

Department of Orthopedic Surgery, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Fibrous Dysplasia is a benign fibro-osseous lesion occurring throughout the skeletal system with a predilection for craniofacial bones, long bones, and ribs. Fibrous dysplasia develops during bone formation and growth with a variable natural evolution. It is considered a genetic nonheritable disease resulting from missense mutations that occur postzygotically in the GNAS1 gene. Read More

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http://dx.doi.org/10.3941/jrcr.v13i2.3379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743863PMC
February 2019
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Secondary desmoplastic fibroma-like tissue changes in mandibular fibrous dysplasia: clinicopathological and molecular study of a case.

Br J Oral Maxillofac Surg 2020 01 26;58(1):96-98. Epub 2019 Sep 26.

Department of Molecular Medicine, Sapienza University of Rome, Italy.

Fibrous dysplasia may show locally aggressive behaviour reflecting secondary intralesional changes, extension to soft tissue, or malignant transformation. We report the case of a patient with polyostotic fibrous dysplasia who had a giant mandibular lesion consisting of histologically typical, genotypically-confirmed, fibrous dysplasia merged with a fibrotic and hypocellular desmoplastic fibroma-like tissue in which the same Gsα-R201H mutation was detected. The occurrence of the same mutation in both the fibrous dysplasia and areas of desmoplastic fibroma suggests that the fibroma-like tissue reflects an unusual secondary tissue change within an otherwise typical fibrous dysplasia. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.09.006DOI Listing
January 2020
3 Reads