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Aktuelle Urol 2019 Mar 27. Epub 2019 Mar 27.

Charité - Universitätsmedizin Berlin, Urologie, Berlin.

The most exciting data presented at the 2017 ASCO Annual Meeting included the results of the LATITUDE and STAMPEDE trials, which evaluated abiraterone plus prednisone combined with androgen-deprivation therapy (ADT) as a first-line treatment in men with newly diagnosed high-risk metastatic hormone-sensitive prostate cancer (mHSPC), demonstrating a practice-changing alternative to chemo-hormonal treatment with docetaxel plus ADT. In both trials, the addition of abiraterone plus prednisone to ADT significantly prolonged both progression-free survival and overall survival. In the absence of head-to-head evidence, it remains unclear if abiraterone plus prednisone and ADT should be the new gold standard for patients with newly diagnosed high-risk mHSPC. Read More

Aktuelle Urol 2019 Mar 21. Epub 2019 Mar 21.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Urologie, Campus Mitte, Berlin.

Background:  Nodal metastasis is a strong prognostic parameter in prostate cancer (PCa). We analysed the detection of micrometastases (miN + ) in initially nodal-negative (pN0) radical prostatectomy specimens from pT2a-c and pT3a PCa patients by immunohistochemistry (IHC).

Material And Methods:  A total of 2352 lymph nodes of 193 PCa patients were centrally re-examined for miN + or miN- status using IHC. Read More

Aktuelle Urol 2019 Mar 21. Epub 2019 Mar 21.

Zentralkrankenhaus Bozen, Abteilung für Urologie, Bozen, Italy.

We report the case of a 64-year-old man, initially diagnosed with a polymorphous adenocarcinoma of the small salivary glands at the tongue base, with occurrence of a penile metastasis ten years after diagnosis. To our knowledge, only two such cases have been described in the literature to date. Read More

Aktuelle Urol 2019 Apr 21;50(2):203-212. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 21;50(2):190-194. Epub 2019 Mar 21.

Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Institut für Sozialmedizin und Epidemiologie, Lübeck.

A trend towards reduced resilience to stress and impaired psychosocial well-being begins early on in medical education. Our own results confirm the early deterioration of the psychosocial health of medical students observed internationally. Students who simultaneously demonstrate high levels of perfectionism, an insufficient ability to distance themselves from work, as well as a lack of regular physical activity appear to form a special risk group. Read More

Aktuelle Urol 2019 Apr 21;50(2):150-152. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 21;50(2):147. Epub 2019 Mar 21.

Klinik für Urologie und Kinderurologie, Helios Universitätsklinikum Wuppertal.

Aktuelle Urol 2019 Apr 21;50(2):143. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 21;50(2):144-145. Epub 2019 Mar 21.

LKP der Studie in Deutschland, Universitätsklinikum Lübeck, Klinik für Urologie, Ratzeburger Allee 160, 23538 Lübeck.

Aktuelle Urol 2019 Apr 21;50(2):143. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 21;50(2):140-143. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 21;50(2):139-140. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 21;50(2):136-139. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 21;50(2):136. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 21;50(2):132-136. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 21;50(2):121-122. Epub 2019 Mar 21.

Aktuelle Urol 2019 Apr 28;50(2):157-165. Epub 2019 Feb 28.

Universitätsmedizin Mannheim, Klinik für Urologie, Mannheim.

Urolithiasis is an urologist's daily business. This article provides an overview of the developments in the management of urinary stone disease since the 1970s. While conventional KUB X-rays and intravenous pyelography were standard imaging procedures in the past, computed tomography is the first choice today. Read More

Aktuelle Urol 2019 Feb 28. Epub 2019 Feb 28.

Aktuelle Urol 2019 Feb 20. Epub 2019 Feb 20.

Alexianer Krefeld GmbH, Klinik für Urologie und Kinderurologie, Krefeld.

Aktuelle Urol 2019 Apr 14;50(2):184-189. Epub 2019 Feb 14.

Ambulantes Rehabilitations-Zentrum für Urologie und Gynäkologie Heidelberg, Facharztpraxis für Urologie, Heidelberg.

In specialist urology clinics, 50 - 70 % of patients have chronic urological diseases such as recurrent urinary tract infections, a somatoform overactive bladder, adult and infantile enuresis, a chronic pelvic pain syndrome, and the psychosomatic form of post-prostatectomy incontinence. The 12-month prevalence of psychological disorders in the general adult population is 28 % 1. As many as 20 % of children and adolescents are found to have psychological abnormalities 2. Read More

Aktuelle Urol 2019 Feb 14. Epub 2019 Feb 14.

Alexianer Krefeld GmbH, Klinik für Urologie und Kinderurologie, Krefeld.

This case report describes the rare entity of Hodgkin's lymphoma manifesting itself in an extralymphatic organ. To rule out a second malignancy, we performed a transurethral resection of the urinary bladder (TUR-B) in our urology department, confirming the histological findings. After that, the patient received oncological treatment based on the current guidelines. Read More

Aktuelle Urol 2019 Feb 7;50(1):113-119. Epub 2019 Feb 7.

Aktuelle Urol 2019 Feb 7;50(1):106-112. Epub 2019 Feb 7.

Aktuelle Urol 2019 Feb 7;50(1):84-93. Epub 2019 Feb 7.

Department of Urology, University Hospital Bern, Switzerland.

The application of next-generation high-throughput techniques for the identification of molecular alterations in tumour tissue has greatly improved our knowledge of the biology of urothelial carcinoma. Gene expression analysis performed as part of the Cancer Genome Atlas project (TCGA) enabled the identification of molecular subtypes with distinct biologic features. The knowledge gained through these analyses could lead to a significant change in the clinical management of patients with urothelial carcinoma through targeted applications. Read More

Aktuelle Urol 2019 Feb 7;50(1):39-55. Epub 2019 Feb 7.

Charité - Universitätsmedizin Berlin, Klinik für Urologie, Berlin.

Urogynaecology is a highly specialised interdisciplinary medical field. It aims to investigate and treat functional, static, endocrine and sexual disorders of the genitourinary system and pelvic area in a sustainable and holistic manner.The "Urological Functional Diagnostics and Female Urology" working group of the German Urologist Academy was founded in 1977. Read More

Aktuelle Urol 2019 Feb 7;50(1):33-34. Epub 2019 Feb 7.

Aktuelle Urol 2019 Feb 7;50(1):23-31. Epub 2019 Feb 7.

We are living in exciting times for urological oncology. The numbers of clinical trials are ever rising, a stream of new substances for tumour therapy is introduced. As it is more challenging than ever to obtain an overview as a clinician, this article aims to summarise the most important news with regard to the 3 most eminent urological tumour entities. Read More

Aktuelle Urol 2019 Feb 7;50(1):22. Epub 2019 Feb 7.

Urologische Klinik, Evangelisches Krankenhaus Witten im Diakoniewerk Ruhr gGmbH.

Aktuelle Urol 2019 Feb 7;50(1):18. Epub 2019 Feb 7.

Aktuelle Urol 2019 Feb 7;50(1):20-21. Epub 2019 Feb 7.

Leiter der klinischen Prüfung (LKP), Uniklinikum Freiburg, Klinik für Innere Medizin I, Hugstetter Str. 55, 79106 Freiburg.

Aktuelle Urol 2019 Feb 7;50(1):16. Epub 2019 Feb 7.

Aktuelle Urol 2019 Feb 7;50(1):16-18. Epub 2019 Feb 7.

Aktuelle Urol 2019 Feb 7;50(1):14-16. Epub 2019 Feb 7.

Aktuelle Urol 2019 Feb 7;50(1):12-14. Epub 2019 Feb 7.

Aktuelle Urol 2019 Feb 7;50(1):12. Epub 2019 Feb 7.

Aktuelle Urol 2019 Feb 7;50(1):1-4. Epub 2019 Feb 7.

Aktuelle Urol 2019 Apr 30;50(2):179-183. Epub 2019 Jan 30.

MVZ-DGU-Die Gesundheitsunion GmbH, Wuppertal.

In their daily routine, urologists in general and uro-oncologists in particular are often confronted with non-urologic complications. To meet the need for measures of symptom control at the interface between genuine urologic and general palliative care, it is necessary for the partners from special outpatient palliative care (SAPV), general outpatient palliative care (AAPV), medical centres and other service units to cooperate. There are a significant number of urological practitioners who have completed trainings in palliative care or passed an exam as 'qualified palliative physician (QPA)'. Read More

Aktuelle Urol 2019 02 17;50(1):e1. Epub 2019 Jan 17.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg.

Aktuelle Urol 2019 Apr 16;50(2):166-171. Epub 2019 Jan 16.

Klinikum rechts der Isar der Technischen Universität München, Roman-Herzog-Krebszentrum, Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, München.

National and international guidelines and certification criteria for comprehensive cancer centres require the psycho-oncological co-treatment of distressed cancer patients. Of course, this also applies to the field of uro-oncology. The individual need for psychosocial support should be systematically evaluated by "distress screening" procedures. Read More

Aktuelle Urol 2019 Apr 10;50(2):172-178. Epub 2019 Jan 10.

Charité - Universitätsmedizin Berlin, Institute of Medical Psychology.

Tumour diseases are accompanied by complex fears and psychological stress, with which the urologist is confronted. This article examines facets of doctor-patient interaction from a psycho-oncological perspective. These include risk perception, lay theories, lifestyle changes, sexuality and, most importantly, dealing with anxiety. Read More

Thromb Haemost 2019 Jan 31;119(1):14-38. Epub 2018 Dec 31.

Thrombosis and Atherosclerosis Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Non-vitamin K antagonist oral anticoagulants (NOACs) include dabigatran, which inhibits thrombin, and apixaban, betrixaban, edoxaban and rivaroxaban, which inhibit factor Xa. In large clinical trials comparing the NOACs with the vitamin K antagonist (VKA) warfarin, dabigatran, apixaban, rivaroxaban and edoxaban were at least as effective for stroke prevention in atrial fibrillation and for treatment of venous thromboembolism, but were associated with less intracranial bleeding. In addition, the NOACs are more convenient to administer than VKAs because they can be given in fixed doses without routine coagulation monitoring. Read More

Aktuelle Urol 2018 Dec 18. Epub 2018 Dec 18.

Universitätsmedizin Mainz, Klinik und Poliklinik für Urologie und Kinderurologie, Mainz.

Aktuelle Urol 2018 Dec 13;49(6):e94. Epub 2018 Dec 13.

Spital Thurgau AG, Urologie, Frauenfeld.

Aktuelle Urol 2019 Feb 13;50(1):100-105. Epub 2018 Dec 13.

Universität Witten/Herdecke, Lehrstuhl für Geriatrie, Witten.

Background:  Since 2015 so-called "ISAR Screening" (Identification of Seniors at Risk) is mandatory for patients older than 75 years being hospitalised in Germany. It remains unclear how these patients identified as suffering from geriatric diseases are further characterised in urology and how this information is applied in the ongoing clinical treatment.

Methods:  From the July 1st to December 31th 2016, 337 patients older than 75 years were subjected to ISAR-screening. Read More

Aktuelle Urol 2019 Feb 12;50(1):56-62. Epub 2018 Dec 12.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg.

Flexible ureteroscopy (fURS) has become a success story in urology. Since its implementation into the treatment of urolithiasis, fURS has demonstrated excellent clinical performance and safety. In recent years, the spread of disposable ureteroscopes has shaped the field of endoscopic stone treatment. Read More

Aktuelle Urol 2018 Dec 6;49(6):530-541. Epub 2018 Dec 6.

Aktuelle Urol 2018 Dec 6;49(6):525-529. Epub 2018 Dec 6.

Johannes Gutenberg Universitat Universitatsmedizin, Klinik und Poliklinik für Urologie und Kinderurologie, Mainz.

Prostate cancer has a heterogeneous genetic profile compared with other tumour entities. Accordingly, there are also various mutations that increase the risk of prostate cancer. Some genetic variants only have a mild impact, whereas other gene mutations (BRCA1 /2; HOXB13) may increase the risk significantly. Read More

Aktuelle Urol 2018 Dec 6;49(6):519-524. Epub 2018 Dec 6.

Spital Thurgau AG, Urologie, Frauenfeld.

The classical algorithm of the management of male lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) includes a surgical approach in case pharmacological therapy has failed. Emerging minimally-invasive treatments (MITs) offer potential for rapid symptomatic relief, reducing the morbidity of invasive BPH surgery. Convective interstitial radiofrequency water vapour thermal ablation of the prostate with the Rezūm system is a novel MIT for the treatment of bothersome moderate-to-severe lower urinary tract symptoms associated with BPH. Read More

Aktuelle Urol 2018 Dec 6;49(6):515-518. Epub 2018 Dec 6.

Klinikum Großhadern/Innenstadt, Ludwig-Maximilians-Universität München, Urologische Klinik und Poliklinik, München.

Minimally-invasive treatment options for patients with LUTS due to benign prostatic obstruction (BPO) become more and more important because they provide equal long-term efficacy compared with the reference method TURP, while having a more favourable safety profile. There are promising results for PUL (Prostatic Urethral Lift - UroLift) with low complication rates. UroLift is clearly superior regarding the preservation of sexual functions without impairment of ejaculatory function. Read More