148,141 results match your criteria Airway Foreign Body Imaging


Persistent Reduction of Mucin Production Following Bronchial Thermoplasty in Severe Asthma.

Am J Respir Crit Care Med 2018 Dec 12. Epub 2018 Dec 12.

Institut universitaire de cardiologie et de pneumologie de Quebec, 55973, Quebec, Quebec, Canada ;

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December 2018

Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough.

Korean J Intern Med 2018 Dec 13. Epub 2018 Dec 13.

Lung Research Institute of Hallym University College of Medicine, Chuncheon, Korea.

Background/aims: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial.

Methods: We conducted a prospective observational study to determine the ICS efficacy and clinical predictors of response to ICS in patients with upper airway cough syndrome (UACS) or unexplained chronic cough (UCC). Sixty-eight patients with UACS and 33 patients with UCC (duration of cough ≥ 8 weeks) were treated with ICS: 250 µg of fluticasone propionate or 400 µg of budesonide twice a day at physician's discretion. Read More

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December 2018

Usefulness of C-MAC video laryngoscope in direct laryngoscopy training in the emergency department: A propensity score matching analysis.

PLoS One 2018 12;13(12):e0208077. Epub 2018 Dec 12.

Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objectives: We determined the usefulness of C-MAC video laryngoscope (C-MAC) as a safe training tool for the direct laryngoscopy technique in the emergency department.

Methods: We retrospectively analyzed an institutional airway registry of adult (≥18 years old) patients from April 2014 through October 2016. In this study, the operator used C-MAC as a direct laryngoscope (DL) with limited access to the screen, and the supervisor instructed the operator via verbal feedback while watching the screen. Read More

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December 2018

Low-Dose Budesonide/Formoterol Counteracts Airway Inflammation and Improves Lung Function in COPD.

Am J Respir Crit Care Med 2018 Dec 12. Epub 2018 Dec 12.

Imperial College London & Royal Brompton Hospital, London, United Kingdom of Great Britain and Northern Ireland.

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December 2018
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Lanadelumab for the Prophylactic Treatment of Hereditary Angioedema with C1 Inhibitor Deficiency: A Review of Preclinical and Phase I Studies.

BioDrugs 2018 Dec 12. Epub 2018 Dec 12.

Division of Rheumatology, Allergy and Immunology, University of California, San Diego, 8899 University Center Lane, Suite 230, San Diego, CA, 92122, USA.

Hereditary angioedema (HAE) with C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) is a rare disease characterized by diminished levels or dysfunctional activity of C1-INH, leading to dysregulated plasma kallikrein activity within the kallikrein-kinin pathway. Symptoms manifest as painful, potentially life-threatening swelling of subcutaneous tissues throughout the body and/or submucosal edema in the upper airway or gastrointestinal tract. Attacks recur with unpredictable frequency, intensity, and duration, placing a heavy burden on patients' daily lives. Read More

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December 2018

Anaesthetic Considerations in a Patient with Pycnodysostosis undergoing Caesarean Delivery.

Case Rep Anesthesiol 2018 13;2018:5675637. Epub 2018 Nov 13.

Department of Anesthesia, Hospital Unit Vest, Herning, Denmark.

Pycnodysostosis is a rare congenital disorder with several implications, which might complicate anesthesia. Patients are more prone to fractures and have an anticipated difficult airway. We report a case of a 34-year-old woman with pycnodysostosis who underwent elective caesarean delivery under epidural blockade. Read More

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November 2018

FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells.

Front Endocrinol (Lausanne) 2018 27;9:708. Epub 2018 Nov 27.

Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.

The hexosamine biosynthetic pathway (HBP) generates the substrate for the O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins. The HBP also serves as a stress sensor and has been reported to be involved with nuclear factor of activated T-cells (NFAT) activation, which can contribute to multiple cellular processes including cell metabolism, proliferation, and inflammation. In our previously published report, Fibroblast Growth Factor (FGF) 23, an important endocrine pro-inflammatory mediator, was shown to activate the FGFR4/phospholipase Cγ (PLCγ)/nuclear factor of activated T-cells (NFAT) signaling in chronic inflammatory airway diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Read More

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November 2018

Gene Therapy for Cystic Fibrosis Lung Disease: Overcoming the Barriers to Translation to the Clinic.

Front Pharmacol 2018 27;9:1381. Epub 2018 Nov 27.

Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.

Cystic fibrosis (CF) is a progressive, chronic and debilitating genetic disease caused by mutations in the CF Transmembrane-Conductance Regulator () gene. Unrelenting airway disease begins in infancy and produces a steady deterioration in quality of life, ultimately leading to premature death. While life expectancy has improved, current treatments for CF are neither preventive nor curative. Read More

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November 2018

A predictive algorithm to identify genes that discriminate individuals with fibromyalgia syndrome diagnosis from healthy controls.

J Pain Res 2018 21;11:2981-2990. Epub 2018 Nov 21.

Symptoms Biology Unit, National Institute of Nursing Research (NINR), Bethesda, MD, USA.

Objectives: Fibromyalgia syndrome (FMS) is a chronic and often debilitating condition that is characterized by persistent fatigue, pain, bowel abnormalities, and sleep disturbances. Currently, there are no definitive prognostic or diagnostic biomarkers for FMS. This study attempted to utilize a novel predictive algorithm to identify a group of genes whose differential expression discriminated individuals with FMS diagnosis from healthy controls. Read More

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November 2018

Evaluating the impact of morning symptoms in COPD using the Capacity of Daily Living during the Morning (CDLM) questionnaire.

Int J Chron Obstruct Pulmon Dis 2018 26;13:3837-3844. Epub 2018 Nov 26.

Pneumology Department, Hospital Universitari Vall d'Hebron/Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain,

Purpose: The aim of this study was to evaluate the impact of morning symptoms in COPD using the Capacity of Daily Living during the Morning (CDLM) questionnaire and to determine the clinical variables that are related to CDLM scores.

Methods: This was an observational, cross-sectional, and multicenter study conducted in stable COPD patients. CDLM scores ranged from 0 to 5 and were transformed into a qualitative variable according to tertile values to compare patient characteristics. Read More

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November 2018

Neonatal intermittent hypoxemia events are associated with diagnosis of bronchopulmonary dysplasia at 36 weeks postmenstrual age.

Pediatr Res 2018 Dec 12. Epub 2018 Dec 12.

Division of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.

Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease and major pulmonary complication after premature birth. We have previously shown that increased intermittent hypoxemia (IH) events have been correlated to adverse outcomes and mortality in extremely premature infants. We hypothesize that early IH patterns are associated with the development of BPD. Read More

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December 2018

Multidrug-resistant tuberculosis (MDR-TB) strain infection in macaques results in high bacilli burdens in airways, driving broad innate/adaptive immune responses.

Emerg Microbes Infect 2018 Dec 12;7(1):207. Epub 2018 Dec 12.

Clinic and Research Center of Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Tuberculosis (TB) has become the most deadly infectious diseases due to epidemics of HIV/AIDS and multidrug-resistant/extensively drug-resistant TB (MDR-/XDR-TB). Although person-to-person transmission contributes to MDR-TB, it remains unknown whether infection with MDR strains resembles infection with drug-sensitive (DS) TB strains, manipulating limited or broad immune responses. To address these questions, macaques were infected with MDR strain V791 and a drug-sensitive Erdman strain of TB. Read More

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December 2018

Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial.

Thorax 2018 Dec 11. Epub 2018 Dec 11.

Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Rationale: Highly prevalent and severe sleep-disordered breathing caused by acute cervical spinal cord injury (quadriplegia) is associated with neurocognitive dysfunction and sleepiness and is likely to impair rehabilitation.

Objective: To determine whether 3 months of autotitrating CPAP would improve neurocognitive function, sleepiness, quality of life, anxiety and depression more than usual care in acute quadriplegia.

Methods And Measurements: Multinational, randomised controlled trial (11 centres) from July 2009 to October 2015. Read More

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December 2018

A COPD Case-Finding Program in a Large Cohort of HIV-Infected Persons.

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.

Background: COPD screening guidelines in patients with HIV are lacking, and data about its under-diagnosis are still limited. This study aimed to determinate the feasibility of a case-finding program and the prevalence of COPD under-diagnosis in a large cohort of HIV-infected subjects.

Methods: All out-patients attending their routine visit for HIV monitoring at Spedali Civili General Hospital in Brescia, Italy, from February 2015 to January 2016, were enrolled. Read More

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December 2018

Objective Versus Self-Reported Adherence to Airway Clearance Therapy in Cystic Fibrosis.

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

Division of Pediatric Pulmonary and Sleep Medicine, as well as the Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Alabama.

Background: Historically, studies of adherence to airway clearance therapy in cystic fibrosis (CF) have relied on self-reporting. We compared self-reported airway clearance therapy adherence to actual usage data from home high-frequency chest wall compressions (HFCWC) vests and identified factors associated with overestimation of adherence in self-reports.

Methods: Pediatric patients who perform airway clearance therapy with a HFCWC vest were eligible to participate. Read More

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December 2018

Neonatal Intubation Practice and Outcomes: An International Registry Study.

Pediatrics 2018 Dec 11. Epub 2018 Dec 11.

Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background And Objectives: Neonatal tracheal intubation is a critical but potentially dangerous procedure. We sought to characterize intubation practice and outcomes in the NICU and delivery room (DR) settings and to identify potentially modifiable factors to improve neonatal intubation safety.

Methods: We developed the National Emergency Airway Registry for Neonates and collected standardized data for patients, providers, practices, and outcomes of neonatal intubation. Read More

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December 2018

Nasal function and CPAP compliance.

Auris Nasus Larynx 2018 Dec 8. Epub 2018 Dec 8.

Department of Otorhinolaryngology, Toho University Graduate School of Medicine, Japan; Department of Otorhinolaryngology, Toho University Omori Medical Center, Japan. Electronic address:

Objective: Continuous positive airway pressure (CPAP) is the mainstay therapy for patients with obstructive sleep apnea (OSA) however compliance with CPAP is variable. Nasal ailments, such as nasal congestion are frequently mentioned as a cause for CPAP non-compliance, and potentially could be addressed prior to CPAP initiation, however, no specific criteria or recommendations for the evaluation and management of these patients exist. The aim of this retrospective study is to evaluate the effects of nasal anatomic features and disease on adherence to CPAP therapy for patients with OSA and determine the indications for pre-CPAP nasal treatment by using data obtained at clinical examination. Read More

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December 2018

Methicillin-Resistant Staphylococcus aureus and Other Multidrug-Resistant Colonizations/Infections in an Intensive Care Unit: Predictive Factors.

Biol Res Nurs 2018 Dec 11:1099800418818387. Epub 2018 Dec 11.

2 Faculty of Nursing, Catholic University of Murcia (UCAM), Murcia, Spain.

Introduction And Objectives:: Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent pathogen causing nosocomial infections in hospitals and health centers. This work is an effort to understand the epidemiology of MRSA and other multidrug-resistant pathogens in an intensive care unit (ICU) and to analyze characteristics that might determine the risk of MRSA colonization/infection in this unit.

Method:: An observational, 1-year prospective longitudinal study was conducted to obtain information about MRSA and other multidrug-resistant colonizations/infections. Read More

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December 2018

Adjunctive tadalafil therapy for managing pulmonary hypertension in a patient with obesity hypoventilation syndrome.

J Cardiol Cases 2011 Oct 23;4(2):e126-e128. Epub 2011 Jul 23.

Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan.

Obesity hypoventilation syndrome (OHS) is often associated with pulmonary hypertension (PH), and noninvasive bi-level positive airway pressure therapy is indicated as first-line treatment. However, its effect in reducing pulmonary arterial pressure is insufficient in many cases, thus adjunctive therapies should be evaluated. In this report, we present a patient with OHS-associated PH who was successfully treated by tadalafil in conjunction with weight reduction and bi-level positive airway pressure therapy. Read More

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October 2011

A Churg-Strauss syndrome patient with myopericardial involvement.

J Cardiol Cases 2015 Feb 11;11(2):52-55. Epub 2014 Nov 11.

Department of Cardiology, Laiko General Hospital, Athens, Greece.

Churg-Strauss syndrome is a necrotizing vasculitis of small vessels characterized by upper and lower airway disease followed by peripheral eosinophilia and multiple organ involvement. Herein we present the case of a 45-year-old female patient with Churg-Strauss syndrome and myopericardial disease who improved upon cyclophosphamide treatment. Apart from discussing the characteristics of myopericardial disease in eosinophilic syndromes, we highlight the crucial role of cardiac imaging in the prompt recognition and management of such patients. Read More

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February 2015

Highly sensitive nitric oxide gas sensor based on ZnO-nanorods vertical resistor operated at room temperature.

Nanotechnology 2018 Dec 11. Epub 2018 Dec 11.

Department of Electronics Engineering, National Chiao-Tung University, 1001 Ta-Hsueh Road, Hsinchu 300, TAIWAN, Hsinchu, TAIWAN.

We successfully demonstrated a simple and low-cost nitric oxide (NO) gas sensor to deliver parts-per-billion (ppb) regime detection at room temperature operation. A vertical-channel ZnO nanorods resistor is fabricated by putting silver nanowire electrode onto the hydrothermal ZnO nanorods film. With suitable process condition, the nanorods film exhibits a uniform morphology to enable the formation of gas-permeable nanowire top electrode while also the nanorods provide good surface-to-volume ratio to deliver strong reaction with NO gas. Read More

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December 2018

Anti-allergic effects of salvianolic acid A and tanshinone IIA from Salvia miltiorrhiza determined using in vivo and in vitro experiments.

Int Immunopharmacol 2018 Dec 8;67:69-77. Epub 2018 Dec 8.

College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:

Salvia miltiorrhiza root has been used in Asian traditional medicine for the treatment of cardiovascular diseases, asthma, and other conditions. Salvianolic acid B from S. miltiorrhiza extracts has been shown to improve airway hyperresponsiveness. Read More

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December 2018
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IL-37 alleviates house dust mite-induced chronic allergic asthma by targeting TSLP through the NF-κB & ERK1/2 signaling pathways.

Immunol Cell Biol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pulmonary Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Institute of Respiratory Diseases of Sun Yat, Sen University, Guangzhou, China.

Interleukin (IL)-37 has been described as a negative regulator of immune responses and is critical for asthma pathogenesis, but the mechanisms behind the protective role of IL-37 against allergic asthma are less well understood. We show here that IL-37 administered intranasally (i.n. Read More

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December 2018

Highly sensitive spectrofluorimetric method for rapid determination of orciprenaline in biological fluids and pharmaceuticals.

Luminescence 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Pharmacy, Pharmaceutical Analytical Chemistry Department, Mansoura University, Mansoura, Egypt.

Orciprenaline sulphate (ORP) is a direct-acting sympathomimetic with mainly beta-adrenoceptor stimulant activity. It is used as a bronchodilator in the management of reversible airway obstruction. For the first time, a rapid highly sensitive spectrofluorimetric method is described that is relied on measuring the fluorescence spectra of ORP at acidic pH and without addition of any chemical reagents. Read More

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December 2018

Laryngeal mask airway versus endotracheal tube for percutaneous dilatational tracheostomy in critically ill adults.

Cochrane Database Syst Rev 2018 Nov 15;11:CD009901. Epub 2018 Nov 15.

Wiesbaden Business School, RheinMain University of Applied Science, Bleichstr. 44, Wiesbaden, Germany, 65183.

Background: Percutaneous dilatational tracheostomy (PDT) is one of the most common bedside surgical procedures performed in critically ill adults, on intensive care units (ICUs), who require long-term ventilation. PDT is associated with relevant life-threatening complications: Cuff rupture or accidental extubation may lead to hypoxia, aspiration or loss of airway. Puncture of the oesophagus, or creating a false passage during dilatation or replacement of the tracheostomy tube, can lead to pneumothorax or emphysema. Read More

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November 2018
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Bismuth Ferrite Second Harmonic Nanoparticles for Pulmonary Macrophage Tracking.

Small 2018 Dec 10:e1803776. Epub 2018 Dec 10.

Translational Molecular Imaging, Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075, Göttingen, Germany.

Recently, second harmonic generation (SHG) nanomaterials have been generated that are efficiently employed in the classical (NIR) and extended (NIR-II) near infrared windows using a multiphoton microscope. The aim was to test bismuth ferrite harmonic nanoparticles (BFO-HNPs) for their ability to monitor pulmonary macrophages in mice. BFO-loaded MH-S macrophages are given intratracheally to healthy mice or BFO-HNPs are intranasally instilled in mice with allergic airway inflammation and lung sections of up to 100 μM are prepared. Read More

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December 2018
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Assessment of within-breath impulse oscillometry parameters in children with asthma.

Pediatr Pulmonol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Background: Impulse oscillometry (IOS) measures respiratory resistance and reactance during tidal breaths and is a convenient tool for evaluation of lung function. Respiratory resistance and reactance can be measured separately during inspiration and expiration (inspiratory-expiratory analysis).

Objective: We investigated the differences in inspiratory-expiratory measurements obtained using IOS between children with and without asthma. Read More

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December 2018

EP and EP receptor antagonists: Impact on cytokine production and β -adrenergic receptor desensitization in human airway smooth muscle.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.

Prostaglandin E (PGE ) is a key prostanoid known to have both proinflammatory and anti-inflammatory impact in the context of chronic respiratory diseases. We hypothesize that these opposing effects may be the result of different prostanoid E (EP) receptor-mediated signaling pathways. In this study, we focus on two of the four EP receptors, EP and EP , as they are known to induce cyclic adenosine monophosphate (cAMP)-dependent signaling pathways. Read More

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December 2018

The effect of inhaled heliox on peak flow rates in normal and brachycephalic dogs.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, Massachusetts.

Background: Heliox, a mixture of helium and oxygen, alleviates airway obstruction in people and improves air flow, and its use has been proposed in dogs. Brachycephalic dogs have naturally occurring airway obstruction where heliox might be a useful therapeutic option.

Objective: The purposes of this study were to (1) determine the impact of breathing heliox on peak inspiratory and expiratory flows (PIF/PEF) in healthy dogs and (2) determine if brachycephalic dogs and mesocephalic dogs have similar responses to inhaled heliox. Read More

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December 2018

Effects of catalpol on bronchial asthma and its relationship with cytokines.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Pediatrics, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.

An animal (BALB/c mice) model of catalpol associated with bronchial asthma in vivo was established, and the effects of catalpol and its relationship with cytokines were investigated. A total of 30 adult BALB/c mice were randomly divided into a positive control group, a model group, and a catalpol group, with 10 mice in each group. The lung function of mice, the cell count, and the cytokine concentrations in bronchoalveolar lavage fluid (BALF) were detected. Read More

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December 2018
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Overview of antibody-mediated immunity to S. pneumoniae: pneumococcal infections, pneumococcal immunity assessment, and recommendations for IG product evaluation.

Transfusion 2018 Dec;58 Suppl 3:3106-3113

Regional Immunology Service, The Royal Hospitals, Belfast Health & Social Care Trust and Queen's University Belfast, Belfast, UK.

Streptococcus pneumoniae (S. pneumoniae) strains colonize the nasopharynx and can cause mucosal infections in the upper airway and middle ear, pneumonias, and invasive infections like bacteremia, sepsis, and meningitis. Over 90 serotypes, defined by the structure of their capsular polysaccharides, are known. Read More

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December 2018

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

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December 2018

OVA-Induced Allergic Airway Inflammation Mouse Model.

Methods Mol Biol 2019 ;1916:297-301

Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, SP, Brazil.

Asthma is a worldwide public health issue, affecting the sufferer's quality of life. Many researchers are extensively studying the cellular processes involved in the affected airways. Experimental asthma using animals has been performed for a long time, mainly applying murine models due to well-known advantages. Read More

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January 2019

Intranasal instillation of miR‑410 targeting IL‑4/IL‑13 attenuates airway inflammation in OVA‑induced asthmatic mice.

Mol Med Rep 2018 Nov 28. Epub 2018 Nov 28.

Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Asthma is a common chronic inflammatory respiratory disease characterised by airway inflammation and hyperresponsiveness. The present study was designed to clarify the effect of intranasal miR‑410 administration in an ovalbumin (OVA)‑induced murine model of asthma. It was found that miR‑410 expression was significantly decreased in the lungs of OVA‑induced asthmatic mice (P<0. Read More

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November 2018
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Upregulated IGF‑1 in the lungs of asthmatic mice originates from alveolar macrophages.

Mol Med Rep 2018 Dec 5. Epub 2018 Dec 5.

Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.

Asthma is characterized by inflammation and remodeling of the airways. Insulin‑like growth factor-1 (IGF‑1) serves an important role in the repair of lung tissue injury and airway remodeling by elevating collagen and elastin content, increasing the thickness of smooth muscle and promoting the proliferation of lung epithelial and interstitial cells, as well as fibroblasts; however, the content of IGF‑1 and its cellular origin in the lungs of patients with asthma remain unknown. In the present study, a mouse model of asthma was constructed. Read More

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December 2018

Significant parameters in the evaluation of donor lungs in single-lung cellular ex vivo lung perfusion.

Interact Cardiovasc Thorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Objectives: Typically, single-lung ex vivo lung perfusion (SL-EVLP) is preferred when there is concern of contamination from the opposite lung. However, a comprehensive assessment of the SL-EVLP has not been completed. The purpose of this study is to compare the physiological parameters of SL-EVLP and double-lung EVLP (DL-EVLP) in the assessment of transplant suitability. Read More

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December 2018

A descriptive analysis of endotracheal intubation in a South African Helicopter Emergency Medical Service.

Afr J Emerg Med 2018 Dec 26;8(4):140-144. Epub 2018 Jul 26.

Department of Emergency Medical Care, University of Johannesburg, South Africa.

Introduction: Helicopter Emergency Medical Services (HEMS) exists to supplement the operations of ground-based emergency care providers, mainly in high acuity cases. One of the important procedures frequently carried out by HEMS personnel is endotracheal intubation. Several HEMS providers exist in South Africa, with a mix of advanced life support personnel, however intubation success rates and adverse events have not been described in any local HEMS operation. Read More

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December 2018

Functional Temporomandibular Joint Reconstruction in Costochondral Grafting of Micrognathia.

Plast Reconstr Surg Glob Open 2018 Oct 2;6(10):e1925. Epub 2018 Oct 2.

Department of Plastic and Reconstructive Surgery, Osaka Medical College, Takatsuki, Japan.

Rib bone and costochondral complex grafting has been used to treat micrognathia classified as Pruzansky type III. To acquire more physiological joint movement, we reconstructed a temporomandibular joint with the glenoid fossa in addition to the mandibular ramus. The patient underwent a tracheostomy to correct her airway obstruction at 2 months of age. Read More

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October 2018
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Characterizing post-extubation negative pressure pulmonary edema in the operating room-a retrospective matched case-control study.

Perioper Med (Lond) 2018 6;7:28. Epub 2018 Dec 6.

1Department of Anesthesiology, E-Da Hospital/E-Da Cancer Hospital, I-Shou University, No 1, Yida Road. Yanchao Dist., Kaohsiung city, 824 Taiwan.

Background: Post-extubation negative pressure pulmonary edema (NPPE) is an uncommon but important anesthesia-related emergency presenting with acute respiratory distress and hypoxemia after removal of airway devices. This study investigated the incidence and associated risk factors for post-extubation NPPE during emergence.

Methods: This retrospective, matched case-control study was conducted by reviewing the post-anesthesia records in Tzu Chi General Hospital, Taiwan. Read More

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December 2018

Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation.

Front Immunol 2018 26;9:2718. Epub 2018 Nov 26.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environmental factors and characterized by airflow obstruction, wheezing, eosinophilia, and neutrophilia of lungs and sputum. Similar to other proinflammatory cytokines, IL-6 is elevated in asthma and plays an active role in this disease. However, the exact molecular mechanism of IL-6 involvement in the pathogenesis of asthma remains largely unknown and the major cellular source of pathogenic IL-6 has not been defined. Read More

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November 2018

Draft Genome Sequences of Two Cystic Fibrosis Strains of Stenotrophomonas maltophilia, AU30115 and AU32848.

Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.

Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.

Stenotrophomonas maltophilia is an opportunistic pathogen causing airway infection in people with cystic fibrosis (CF). Here, we report the draft genome sequences of two S. maltophilia strains, AU30115 and AU32848, recovered from CF patients. Read More

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September 2018

Comparison Between Lidocaine Inhalation and Intravenous Dexamethasone in Reducing Postoperative Sore Throat Frequency After Laryngeal Mask Insertion.

Anesth Pain Med 2018 Oct 25;8(5):e82131. Epub 2018 Aug 25.

Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia.

Background: The frequency of postoperative sore throat (POST) after laryngeal mask airway insertion (LMA) was relatively high. Lidocaine might reduce the pain and inflammatory response. Additionally, inhalation form might result in a better distribution, which results in a better airway analgesia and minimal systemic effect. Read More

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October 2018

The Obv-Eas Method: An Easy Way to Facilitate Fiberoptic Intubation in Pediatric Patients: Case of an Infant with Freeman-Sheldon Syndrome.

Anesth Pain Med 2018 Oct 18;8(5):e81451. Epub 2018 Sep 18.

Orthopedics Surgery, Selcuk University Medical Faculty, Konya, Turkey.

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October 2018

A Large Substernal Goiter that Extended to Both Sides of the Thorax.

Case Rep Surg 2018 5;2018:6107982. Epub 2018 Nov 5.

Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.

Most substernal goiters can be managed through the transcervical approach, but a sternotomy is required in some cases. This report is about a large substernal goiter, which was resected via a transcervical and full sternotomy approach. The patient was a 57-year-old female, who visited our hospital for surgical treatment for a large substernal goiter. Read More

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November 2018

Tongue Function: An Underrecognized Component in the Treatment of Obstructive Sleep Apnea with Mandibular Repositioning Appliance.

Can Respir J 2018 6;2018:2157974. Epub 2018 Nov 6.

Department of Orthodontics, Case Western Reserve University, Cleveland, USA.

Obstructive sleep apnea (OSA) is a common but still underrecognized disorder. A mandibular repositioning appliance (MRA) is used to treat OSA by advancing the mandible and thereby reducing the collapsibility of the upper airway. It has been found that an MRA increases the volume of the upper airway, especially the velopharyngeal area, in OSA patients. Read More

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November 2018
1.663 Impact Factor

Anesthetic challenges in a child with Lowe's and Fanconi syndrome.

Indian J Anaesth 2018 Nov;62(11):900-902

Department of Anesthesiology, Critical Care and Pain Medicine, AIIMS, New Delhi, India.

Oculocerebrorenal syndrome of Lowe is a rare X-linked metabolic disorder complicated by Fanconi's syndrome. Anaesthetic management of Lowe syndrome with Fanconi's syndrome is challenging to the anaesthesiologists in view of difficult airway due to microcephaly, metabolic abnormalities, and risk of peri-operative seizures. We report a successful anaesthetic management of a case of 2-year-old child scheduled for evaluation under anaesthesia following bilateral lens aspiration surgery. Read More

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November 2018
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A comparative evaluation of ProSeal laryngeal mask airway, I-gel and Supreme laryngeal mask airway in adult patients undergoing elective surgery: A randomised trial.

Indian J Anaesth 2018 Nov;62(11):858-864

Department of Anesthesia, Maulana Azad Medical College, New Delhi, India.

Background And Aims: Second-generation supraglottic airway devices are widely used in current anaesthesia practice. This randomised study was undertaken to evaluate and compare laryngeal mask airway: ProSeal laryngeal mask airway (PLMA), Supreme laryngeal mask airway (SLMA) and I-gel.

Methods: Eighty-four adult patients undergoing elective surgery were randomly allocated to three groups: group (PLMA), group I (I-gel) and group S (SLMA) of 28 patients each. Read More

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November 2018

CDHR3 extracellular domains EC1-3 mediate rhinovirus C interaction with cells and as recombinant derivatives, are inhibitory to virus infection.

PLoS Pathog 2018 Dec 10;14(12):e1007477. Epub 2018 Dec 10.

Institute for Molecular Virology, Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Viruses in the rhinovirus C species (RV-C) are more likely to cause severe wheezing illnesses and asthma exacerbations in children than related isolates of the RV-A or RV-B. The RV-C capsid is structurally distinct from other rhinoviruses and does not bind ICAM-1 or VLDL receptors. The RV-C receptor is instead, human cadherin-related family member 3 (CDHR3), a protein unique to the airway epithelium. Read More

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December 2018

New physiological insights in ventilation during cardiopulmonary resuscitation.

Curr Opin Crit Care 2018 Dec 5. Epub 2018 Dec 5.

SAMU74, Emergency Department, General Hospital of Annecy, Annecy.

Purpose Of Review: In the setting of cardiopulmonary resuscitation (CPR), classical physiological concept about ventilation become challenging. Ventilation may exert detrimental hemodynamic effects that must be balanced with its expected benefits. The risks of hyperventilation have been thoroughly addressed, even questioning the need for ventilation, emphasizing the need to prioritize chest compression quality. Read More

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December 2018

Optimizing respiratory management in resource-limited settings.

Curr Opin Crit Care 2018 Dec 5. Epub 2018 Dec 5.

Department of Intensive Care.

Purpose Of Review: This review focuses on the emerging body of literature regarding the management of acute respiratory failure in low- and middle-income countries (LMICs). The aim is to abstract management principles that are of relevance across a variety of settings where resources are severely limited.

Recent Findings: Mechanical ventilation is an expensive intervention associated with considerable mortality and a high rate of iatrogenic complications in many LMICs. Read More

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December 2018