6,549 results match your criteria Aids Research And Human Retroviruses[Journal]

Lessons learned from an HIV pre-exposure prophylaxis coordination program in San Francisco primary care clinics.

AIDS Res Hum Retroviruses 2022 May 20. Epub 2022 May 20.

University of California, San Francisco, Medicine, 550 16th St., 3rd floor, UCSF Box 0886, San Francisco, California, United States, 94143;

HIV pre-exposure prophylaxis (PrEP) has shown high efficacy and effectiveness for HIV prevention; however, many individuals with PrEP indications are not receiving PrEP. PrEP Coordinators work closely with patients and healthcare providers to increase PrEP access, and they provide unique insights into the inner workings of PrEP care and service delivery. Here, we discuss key challenges and recommendations for improved PrEP service delivery (including training PrEP Coordinators to manage PrEP panels, making PrEP a part of routine care and optimizing EHRs, designating a PrEP "champion" who can strengthen communication and leadership, using a proactive approach to increase PrEP retention, and training providers and PrEP Coordinators to meet youth-specific needs) from our discussions with the PrEP Coordinators who led PrEP panel management in San Francisco Department of Public Health primary care clinics. Read More

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Reaching males and young adults in a pharmacy-based HIV self-testing strategy: Results from an acceptability study in Mozambique.

AIDS Res Hum Retroviruses 2022 May 17. Epub 2022 May 17.

Vanderbilt University Medical Center (VUMC), Department of Medicine, Division of Infectious Diseases , 1161 21st Avenue South, A-2200 Medical Center North (MCN), Nashville , Tennessee, United States, 37232.

Introduction HIV self-testing (HIVST) is a WHO recommended strategy to increase testing, especially among key populations, men, and young adults. Between May - December 2019, a pilot was implemented in Zambézia province, Mozambique, allowing clients to purchase HIV self-tests in 14 public/private pharmacies. The study assessed the strategy's acceptability and uptake. Read More

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Short Communication │ Awareness of HIV self-care interventions across global regions: results from a values and preferences survey.

AIDS Res Hum Retroviruses 2022 May 17. Epub 2022 May 17.

KEMRI, 118982, Nairobi, Kenya.

The high burden of HIV in sub-Saharan Africa places significant demands on healthcare services. Interventions such as HIV self-testing, and pre- and post-exposure prophylaxis (PrEP and PEP) could empower individuals to determine their HIV status and prevent HIV acquisition. In 2018, the World Health Organisation disseminated an online, anonymous, global values and preferences survey to adults aged 18 and over. Read More

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Perceptions of risks and benefits of participating in HIV cure-related research among diverse young adults living with HIV in the United States: qualitative research findings.

AIDS Res Hum Retroviruses 2022 May 17. Epub 2022 May 17.

UNC-Chapel Hill, 2331, Public Health Leadership Program, Chapel Hill, North Carolina, United States;

In the United States, young adults have the highest rates of new HIV infections, and are less likely to be aware of their infection, be engaged in care, or achieve HIV viral suppression. As biomedical HIV research increasingly focuses on achieving long-term suppression without antiretroviral therapy (ART) and finding an HIV cure, little is known about perceptions of young adults living with HIV (YLWH) regarding HIV cure research. We recruited a diverse sample of 20 YLWH (18-29 years old) to participate in individual semi-structured qualitative interviews to explore knowledge and perceptions of HIV cure research, and motivations and barriers to participation. Read More

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Contribution of Innate Lymphoid Cells in Supplementing Cytokines Produced by CD4+ T-cells During Acute and Chronic SIV Infection of the Colon.

AIDS Res Hum Retroviruses 2022 Apr 22. Epub 2022 Apr 22.

Rush University Medical Center, 2468, Microbial Pathogens and Immunity, Chicago, Illinois, United States;

HIV/SIV infection leads to a loss of CD4+ T-helper (Th) cells in number and function that begins during the acute phase and persists through the chronic phase of infection. In particular, there is a drastic decrease of Th17 and Th22 cells in the HIV/SIV-infected gastrointestinal (GI) tract as a source of Interleukin (IL)-17 and IL-22. These cytokines are vital in the immune response to extracellular pathogens and maintenance of the GI tract. Read More

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Quality of Life and Antiretroviral Therapy Adherence: A Cross-Sectional Study in Colombia.

AIDS Res Hum Retroviruses 2022 May 24. Epub 2022 May 24.

Post Graduation Program in Medicine and Health (PPgMS), Federal University of Bahia, Salvador, Brazil.

The introduction of highly active combined antiretroviral therapy (cART) has changed the management of HIV/AIDS, which is recognized as a chronic disease with relevant aspects, such as adherence and quality of life. This study aimed to compare clinical and demographic characteristics and health-related quality of life in people with adherence and non-adherence to cART. A cross-sectional study was carried out with 200 participants. Read More

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Fecal Microbiota Transplantation for People Living with Human Immunodeficiency Virus: A Scoping Review.

AIDS Res Hum Retroviruses 2022 May 24. Epub 2022 May 24.

Faculty of Human Medicine, Scientific University of the South, Lima, Peru.

The aim of this scoping review was to determine the characteristics of studies evaluating fecal microbiota transplantation (FMT), as well as its effects and safety as a therapeutic intervention for people living with human immunodeficiency virus (HIV). We conducted a scoping review following the methodology of the Joanna Briggs Institute. We searched the following databases: PubMed, Web of Science, Scopus, Embase, Cochrane Library, and Medline until September 19, 2021. Read More

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A Heavy Burden: Preexisting Physical and Psychiatric Comorbidities and Differential Increases Among Male and Female Participants After Initiating Antiretroviral Therapy in the HIV Outpatient Study, 2008-2018.

AIDS Res Hum Retroviruses 2022 May 18. Epub 2022 May 18.

Division of HIV/AIDS Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Attention to non-AIDS comorbidities is increasingly important in the HIV care and management in the United States. We sought to assess comorbidities before and after antiretroviral therapy (ART) initiation among persons with HIV (PWH). Using the 2008-2018 HIV Outpatient Study (HOPS) data, we assessed changes in prevalence of physical and psychiatric comorbidities, by sex, among participants initiating ART. Read More

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HIV infection progression monitoring system based on CD4 counts and Wishart-distribution.

AIDS Res Hum Retroviruses 2022 Apr 18. Epub 2022 Apr 18.

University of Zambia School of Medicine, 119183, Mathematics & Statistics, Box 32375, Lusaka, Lusaka, Lusaka, Zambia, 32375;

The human immunodeficiency virus (HIV) is a viral infection that destroys the human immune system, resulting in the acquired immunodeficiency syndrome (AIDS). The management and care of patients on antiretroviral therapy (ART) consumes a large portion of the health budget of many countries. ART improves the lives of the HIV patients. Read More

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Genital Cytokines in HIV/Human Papillomavirus Co-Infection: A Systematic Review.

AIDS Res Hum Retroviruses 2022 May 11. Epub 2022 May 11.

Postgraduate Program in Medicine and Health (PPgMS), Federal University of Bahia, Salvador, Brazil.

Cervical cancer is the fourth cancer in incidence and the third in mortality among women worldwide. Women living with HIV have a significantly increased risk of cervical cancer. The immune response of the host is crucial to determine the course of the human papillomavirus (HPV) infection and cytokines play an important role modulating viral multiplication and concentrating the immune response in the Th1 or Th2 pattern. Read More

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Untargeted Plasma Metabolomics Reveals Extensive Metabolic Alterations Among Treatment-Naive Human Immunodeficiency Virus/Hepatitis C Virus Co-Infected Patients with Liver Disease Progression.

AIDS Res Hum Retroviruses 2022 05;38(5):378-393

Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.

Both human immunodeficiency virus (HIV) and hepatitis C virus (HCV) may induce metabolic disorders and cause liver complications. Therefore, we aim to analyze the metabolite differences among treatment-naive HIV/HCV co-infected patients with versus without liver disease progression (LDP) and HIV mono-infected patients. A cross-sectional study was conducted in 65 HIV/HCV co-infected patients (22 with LDP and 43 without) and 65 HIV mono-infected patients in Dehong prefecture of Yunnan province, China. Read More

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Degree of Polypharmacy and Cognitive Function in Older Women with HIV.

AIDS Res Hum Retroviruses 2022 Apr 26. Epub 2022 Apr 26.

Albert Einstein College of Medicine, Bronx, New York, USA.

The number of people with HIV (PWH) experiencing age-associated comorbidities including those treated with medications and cognitive impairment is increasing. We examined associations between polypharmacy and cognition in older women with HIV (WWH) given their vulnerability to this comorbidity. Cross-sectional analysis capitalizing on Women's Interagency HIV Study data collected between 2014 and 2017. Read More

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Use of Generic Antiretroviral Drugs and Single-Tablet Regimen De-Simplification for the Treatment of HIV Infection in Spain.

AIDS Res Hum Retroviruses 2022 May 2. Epub 2022 May 2.

CIBER de Enfermedades Infecciosas, Institute of Health CArlos III, Madrid, Spain.

The present study sought to describe the use of generic drugs and single-tablet regimen (STR) de-simplification for the treatment of human immunodeficiency virus (HIV) infection among 41 hospitals from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). In June 2018, we collected information on when generic antiretroviral drugs (ARVs) were introduced in the different hospitals, how the decisions to use them were made, and how the information was provided to the patients. Most of the nine available generic ARVs in Spain by June 2018 had been introduced in at least 85% of the participating hospitals, except for zidovudine (AZT)/lamivudine (3TC) and AZT. Read More

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Outcomes of Dual Versus Triple Antiretroviral Drug Regimens Among Virally Suppressed Adults in the DC Cohort.

AIDS Res Hum Retroviruses 2022 Mar 23. Epub 2022 Mar 23.

Division of Infectious Diseases, Children's National Hospital, Washington, District of Columbia, USA.

This study explored virological outcomes of two-drug (2DRs) and three-drug (3DRs) antiretroviral regimens in adults with HIV in the DC Cohort. We analyzed 310 treatment-experienced adults with sustained HIV RNA ≤50 copies/mL at baseline, 53 of whom switched to 2DRs and 257 continued 3DRs. Adults on 2DRs and 3DRs had similar demographics (median age 53. Read More

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Correlation Between Polypharmacy and Frailty Among Thai Older Persons Living with HIV.

AIDS Res Hum Retroviruses 2022 Apr 25. Epub 2022 Apr 25.

HIV Netherlands Australia Thailand (HIV-NAT) Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

Polypharmacy and frailty are correlated in Persons Living with HIV (PLWH) in the United States, but little is known about their correlation in resource-limited settings. Our cross-section study evaluated the correlation between polypharmacy and frailty among Thai 324 virally suppressed PLWH and 132 uninfected patients aged ≥50 between March 2016 and April 2017. The primary predictor was the number of patient-reported non-antiretroviral therapy (ART) medications. Read More

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Participant Perspectives and Experiences Following an Intensively Monitored Antiretroviral Pause in the United States: Results from the AIDS Clinical Trials Group A5345 Biomarker Study.

AIDS Res Hum Retroviruses 2022 Apr 21. Epub 2022 Apr 21.

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

The AIDS Clinical Trials Group A5345 study (NCT03001128) included an intensively monitored antiretroviral pause (IMAP), during which participants living with HIV temporarily stopped antiretroviral treatment (ART) in an effort to identify biomarkers that could predict HIV rebound. We evaluated the potential impact of the IMAP on A5345 study participants in the United States by questioning them immediately after the IMAP and at the end of the study. We administered longitudinal sociobehavioral questionnaires to participants following the IMAP when they resumed ART and at the end of the study. Read More

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Lipidome Alterations with Exercise Among People With and Without HIV: An Exploratory Study.

AIDS Res Hum Retroviruses 2022 Apr 21. Epub 2022 Apr 21.

Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.

Age-related comorbidities and physical function impairments in aging people with HIV (PWH) can be improved through exercise interventions. The mechanisms underlying these improvements, including lipidomic changes, are unknown. Sedentary adults (50-75 years old) with or without HIV participated in supervised endurance/resistance exercise for 24 weeks. Read More

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Molecular Characterization of the Gene of Vertically Transmitted HIV-1 Strains in Children with Virological Failure.

AIDS Res Hum Retroviruses 2022 May 16. Epub 2022 May 16.

ICMR-National Institute for Research in Tuberculosis, Chennai, India.

HIV-1 gene sequences were analyzed from 77 HIV-1 positive children infected perinatally and exhibiting virological failure (VF). Viral subtyping, phylogenetic analysis, and genotypic drug resistance analysis were carried out on samples collected before start of anti retroviral treatment (ART) (baseline, BL), and at 12 months post-ART initiation (M12). Subtype C was found to be most predominant, seen in 75 of the 77 (97. Read More

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High Proportion of Blood-Borne and Sexually Transmitted Infections Among People Deprived of Liberty in a Central Male Prison in Thailand: A Cross-Sectional Study 2018-2019.

AIDS Res Hum Retroviruses 2022 05 31;38(5):370-377. Epub 2022 Mar 31.

HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

Data are lacking or outdated on burden of HIV, viral hepatitis infection, and sexually transmitted infections such as syphilis among people deprived of liberty in the Asia-Pacific region. We aimed to evaluate the proportion of viral hepatitis B (HBV), hepatitis C (HCV), HIV, and syphilis infections, and factors associated with HCV, HBV, and HIV infection in a central male prison. A cross-sectional study was performed among 1,028 people deprived of liberty from a central male prison in Bangkok, Thailand. Read More

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Factors Associated with Treatment Outcomes Among Children and Adolescents Living with HIV Receiving Antiretroviral Therapy in Central Kenya.

AIDS Res Hum Retroviruses 2022 Mar 30. Epub 2022 Mar 30.

Division of Global HIV and TB, Centers for Disease Control and Prevention, Nairobi, Kenya.

Expanded access to HIV treatment services has improved outcomes for children and adolescents living with HIV in Kenya. Minimal data are available on these outcomes. We describe temporal trends in outcomes for children and adolescents initiating antiretroviral therapy (ART) from 2004 to 2014 at sites supported by Centre for Health Solutions-Kenya, in central Kenya. Read More

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High Rate of HIV-1 Drug Resistance in Antiretroviral Therapy-Failure Patients in Liaoning Province, China.

AIDS Res Hum Retroviruses 2022 Apr 25. Epub 2022 Apr 25.

Institute for Preventive Medicine of China Medical University, Shenyang, China.

This study aimed to monitor the prevalence of HIV-1 drug resistance and risk factors associated with drug resistance in antiretroviral therapy (ART)-failure individuals in Liaoning Province, China. Plasma samples were collected from HIV-1-positive individuals who experienced ART failure in Liaoning Province between April 2018 and September 2019. Genotype resistance test was performed using an in-house assay on these collected samples. Read More

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Understanding Retention in Pre-Exposure Prophylaxis Care in the South: Insights from an Academic HIV Prevention Clinic.

AIDS Res Hum Retroviruses 2022 04;38(4):306-312

Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.

HIV pre-exposure prophylaxis (PrEP) is poorly utilized in the southern United States. We examined PrEP retention in care and sexually transmitted infections (STIs) through a retrospective review of the Duke University PrEP Clinic from January 1, 2015 to October 15, 2019. We evaluated short-term (3 months), long-term (additional 8-12 months), and longitudinal retention in care in our clinic. Read More

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Long-Term Effectiveness of Rilpivirine-Based Single-Tablet Regimens in a Seven-Year, Two-Center Observational Cohort of People Living with HIV.

AIDS Res Hum Retroviruses 2022 Mar 15. Epub 2022 Mar 15.

Infectious Diseases Clinic, Department of Health Sciences, University of Genoa, San Martino Hospital-IRCCS, Genoa, Italy.

Data on the long-term durability of rilpivirine (RPV) are still scarce. A two-center retrospective study was performed, including all people living with HIV (PLWH) treated with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC)/RPV or tenofovir alafenamide (TAF)/FTC/RPV in the period January 2013-December 2019. Aims of the study were to assess the rate of discontinuation of the RPV single-tablet regimen (STR) and identify factors associated with the risk of discontinuation according to Cox's regression analysis. Read More

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Identification of Two Novel HIV-1 Unique Recombinant Forms in Shenzhen, China.

AIDS Res Hum Retroviruses 2022 Mar 21. Epub 2022 Mar 21.

School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Homosexual contact is one of the main transmission routes of the HIV-1 epidemic in Shenzhen. Several subtypes of HIV-1 are prevalent among men who have sex with men simultaneously, which provides favorable conditions for the formation of a unique recombinant form (URF). In this study, we reported two URFs of HIV-1 (LS10525 and LS13740) infected through homosexual contact in Shenzhen. Read More

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Prior Infection with Coccidioidomycosis in Nonhuman Primates and Impact on Simian Immunodeficiency Virus Disease and Vaccine Immunogenicity.

AIDS Res Hum Retroviruses 2022 05 22;38(5):347-349. Epub 2022 Mar 22.

Department of Microbiology, University of Washington, Seattle, Washington, USA.

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Short Communication: Prolonged COVID-19 Infection in a Patient with Newly Diagnosed HIV/AIDS.

AIDS Res Hum Retroviruses 2022 05 16;38(5):399-400. Epub 2022 Mar 16.

Department of Internal Medicine, Rijnstate Hospital Arnhem, Arnhem, The Netherlands.

A 38-year-old male patient presented to the emergency department with fever and dyspnea. Hospitalization was warranted and soon coronavirus disease 2019 (COVID-19) was diagnosed based on a positive SARS-CoV-2-PCR. Over the following weeks his condition gradually worsened, leading to admission at the intensive care unit. Read More

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Short Communication: Ongoing Impact of the Social Determinants of Health During the Second and Third Waves of the COVID-19 Pandemic in People Living with HIV Receiving Care in a Montreal-Based Tertiary Care Center.

AIDS Res Hum Retroviruses 2022 05 14;38(5):359-362. Epub 2022 Mar 14.

Division of Infectious Diseases/Chronic Viral Illness Service, McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada.

We performed retrospective chart reviews and described the clinical characteristics, exposure risks, and disease severity of people living with HIV (PLWH) attending the Chronic Viral Illness Service (CVIS) in Montreal, Canada, who developed coronavirus disease 2019 (COVID-19) during September 2020-August 2021, coinciding with the second and third waves of the pandemic. A total of 61 PLWH with a positive COVID-19 polymerase chain reaction were identified, giving a COVID-19 prevalence of 5%. The most common exposure risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during waves two and three was having a family member/close contact with COVID-19 (36%). Read More

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Class-Based Antiretroviral Exposure and Cognition Among Women Living with HIV.

AIDS Res Hum Retroviruses 2022 Mar 2. Epub 2022 Mar 2.

Division of Infectious Diseases, Georgetown University Medical Center, Washington, District of Columbia, USA.

Neurologic complications of the human immunodeficiency virus (HIV) are common in treated individuals, and toxicity of certain antiretroviral therapies (ART) may contribute to cognitive impairment. We investigated exposures to specific ART and cognition among women living with HIV (WLWH). Virologically suppressed (viral load <200 copies/mL during at least two semi-annual visits) WLWH and age/race matched HIV-seronegative controls enrolled in the Women's Interagency HIV Study who completed at least two biennial cognitive assessments were included. Read More

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Characterization of a New HIV-1 CRF01_AE/B Recombinant Virus Form Among Men Who Have Sex with Men in Baoding, Hebei, China.

AIDS Res Hum Retroviruses 2022 03;38(3):237-241

Department of Clinical Laboratory Medicine, The People's Hospital of Baoding, Baoding, China.

We analyzed the near full-length genome (NFLG) of an HIV-1-positive sample(027A) with an undetermined subtype to determine the recombinant characteristics and possible source of the parental virus. 027A is a novel HIV-1 second-generation recombinant form composed of CRF01_AE and subtype B, detected from a married HIV-1-positive male subject who was infected through homosexual transmission in Baoding, Hebei province, China. The NFLG phylogenetic tree analysis suggested that the strain was close to circulation recombinant forms' (CRFs') reference sequences involved with CRF01_AE, but formed a distinct monophyletic cluster separately from them. Read More

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AIDS Research and Human Retroviruses.

AIDS Res Hum Retroviruses 2022 02 24;38(2):75. Epub 2022 Jan 24.

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February 2022