2,353 results match your criteria Ai zheng = Aizheng = Chinese journal of cancer[Journal]


A case of myxoid chondrosarcoma arising from caput costae.

Ai Zheng 2009 Aug;28(8):894-6

Department of Pathology, Qinghai Province People's Hospital, Xining, Qinghai, 810007, P.R. China.

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August 2009
3 Reads

[Vascular endothelial growth factor (VEGF)-D in association with VEGF receptor-3 in lymphatic metastasis of breast cancer].

Authors:
Ya-Ning Chen Yan Gu

Ai Zheng 2009 Dec;28(12):1337-43

Department of General Surgery, Shanghai Ninth People's Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai, 200011,P. R. China.

Breast carcinoma is the most common malignant tumor in women. For these patients, lymph node metastasis is one of the most important prognostic factors. Recent studies suggest that lymphangiogenesis can contribute to the lymphatic metastasis in tumors. Read More

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December 2009

[Progress on the subcellular localization of Daxx].

Ai Zheng 2009 Dec;28(12):1333-6

Institute of Pathogenic Biology,University of South China, Hengyang, Hunan, 421001,P. R. China.

As a highly conserved nuclear protein, death domain-associated protein(Daxx) plays an important role in transcriptional control, carcinogenesis, resistance to virus infection, and so on. Daxx can be localized in promyleocytic leukaemia protein oncogenic domains, nucleoplasm, nucleolus, cytoplasm, and heterochromatin. The subcellular localization of Daxx can be changed by modification or interacting with other proteins. Read More

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December 2009
2 Reads

[Expression of B7-H1 protein in human pancreatic carcinoma tissues and its clinical significance].

Ai Zheng 2009 Dec;28(12):1328-32

Department of Oncology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, P. R. China.

Background And Objective: B7-H1, a member of B7 family, is expressed in tumor cells and has emerged as an important immune modulator capable of suppressing host immunity by inhibiting T cells function. This study was to probe into the correlation between the expression level of B7-H1 protein in pancreatic carcinoma tissues and clinicopathological characteristics and prognosis.

Methods: The expression of B7-H1 was measured in 40 cases of pancreatic carcinoma tissues and 10 cases of normal corresponding paracarcinoma tissues by immunohistochemistry. Read More

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December 2009
2 Reads

[Clinical research on recombinant human Ad-p53 injection combined with cisplatin in treatment of malignant pleural effusion induced by lung cancer].

Ai Zheng 2009 Dec;28(12):1324-7

Department of Oncology,The First Affiliated Hospital of Liaoning Medical University,Jinzhou, Liaoning, 121001, P. R. China.

Background And Objective: p53 gene is one of cancer suppressor genes and its mutation and deletion induces almost all human cancers. This study was to evaluate the clinical efficacy and toxicity of recombinant human Ad-p53 injection (rAd-p53) combined with cisplatin in treatment of malignant pleural effusion induced by lung cancer.

Methods: A total of 35 cases of malignant pleural effusion were randomly divided into the combined group (n=17) and the single-agent group (n=18). Read More

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December 2009
6 Reads

[Efficacy of cetuximab combined with chemotherapy on advanced colorectal cancer: a report of 53 cases].

Ai Zheng 2009 Dec;28(12):1317-23

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China.

Background And Objective: Studies showed that cetuximab combined with chemotherapy was effective on advanced colorectal cancer (ACRC) in recent years, however, few reports based on large case cohort are available in China. This study was to analyze the efficacy of cetuximab combined with chemotherapy for 53 chinese patients with ACRC.

Methods: Clinical data of 53 patients with ACRC, treated with cetuximab combined with chemotherapy in Sun Yat-sen Cancer Center from March 2005 to April 2008, were analyzed for short-term efficacy and safety. Read More

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December 2009
3 Reads

[Clinical characteristics and prognosis of very young patients with breast cancer in the southern of China].

Ai Zheng 2009 Dec;28(12):1310-6

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China.

Background And Objective: Even though most breast cancers occur in postmenopausal women in western countries, age <35 is one of the prognostic factors. This study was to compare the clinicopathologic characteristics and prognosis between premenopausal breast cancer patients aged of <35 and > or =35 in south China, and to explore the prognostic factors.

Methods: A total of 905 consecutive premenopausal patients were evaluated, with first diagnosis of breast cancer referred to surgery at the Sun Yat-sen University Cancer Center from October 2003 to December 2006. Read More

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December 2009

[Efficacy and survival of 92 cases of Ewing's sarcoma family of tumor initially treated with multidisciplinary therapy].

Ai Zheng 2009 Dec;28(12):1304-9

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060,P. R. China.

Background And Objective: Ewing's sarcoma family of tumor (ESFT) is aggressive. The optimal therapy modality for ESFT is still to be found. This study was to explore the clinical characteristics and therapy for ESFT. Read More

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December 2009
3 Reads

[Correlation of hypermethylation of TSP1 gene with TGF-beta1 level and T cell immunity in gastric cardia adenocarcinoma].

Ai Zheng 2009 Dec;28(12):1298-303

Hebei Cancer Institute,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011,P. R. China.

Background And Objective: Thrombospondin-1(TSP1) is an inhibitor of angiogenesis and its promoter hypermethylation has been found resulting in gene silencing in some primary human carcinomas. This study was to investigate the promoter methylation of TSP1 and its correlation with TGF-beta1 level and T cell immunity in gastric cardia adenocarcinoma (GCA).

Methods: Methylation specific polymerase chain reaction (MSP) approach and immunohistochemistry method were used to examine the methylation status of the 5' CpG island and expression of TSP1 protein, respectively. Read More

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December 2009
4 Reads

[Correlation of the sensitivity of NP chemotherapy in non-small lung cancer with DNA repair gene XRCC1 polymorphism].

Ai Zheng 2009 Dec;28(12):1291-7

Cancer Control Laboratory of Cancer Institute and General Surgery Institute, The First Affiliated Hospital of China Medical University,The Key Laboratory of Cancer Control of Liaoning Province, Shenyang, Liaoning, 110001,P. R. China.

Background And Objective: The gene polymorphism is used to predict the sensitivity of chemotherapy, which is significant for the individualized treatment of tumor. This study was to explore the correlation of codon 194 and codon 399 polymorphisms of DNA repair gene X-ray repair cross complementing (XRCC1) with the sensitivity of non-small cell lung cancer (NSCLC) to NP (vinorebine and cisplatin) chemotherapy.

Methods: XRCC1 polymorphisms at codon 194 and codon 399 were detected in 164 patients with NSCLC using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Read More

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December 2009

[LRP16 gene function based on bioinformatic analysis].

Ai Zheng 2009 Dec;28(12):1283-90

Department of Geriatric Hematology, PLA General Hospital, Beijing 100853, P. R. China.

Background And Objective: LRP16 is a human novel gene linked to leukemia identified recently. However, its biological function is not fully clarified so far. This study was to investigate the biological function of human LRP16 gene by database-aided bioinformatics analysis. Read More

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December 2009
4 Reads

[Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality].

Authors:
Ying Gao Bo Zhang

Ai Zheng 2009 Dec;28(12):1277-82

Department of Pathology, Health Science Center of Peking University, Beijing, 100191, P. R. China.

Background And Objective: Telomerase transcriptional elements-interacting factor (TEIF) gene found recently by our research group is a transcription factor of a kind of human telomerase reverse transcriptase (hTERT) gene, and expresses in many kinds of tumor tissues. This study was to evaluate the expression of TEIF protein in human colorectal tumors and to explore its correlation with centrosome abnormality.

Methods: The expression of TEIF in 10 specimens of normal intestinal mucosa tissue, 30 specimens of colorectal cancer, and 54 specimens of colorectal adenoma was detected by immunohistochemistry. Read More

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December 2009

[Synergistic cytotoxicity effect of histone deacetylase inhibitor combined with paclitaxel on lung cancer cell lines and its mechanism].

Ai Zheng 2009 Dec;28(12):1270-6

Geriatric Respiratory Department,PLA General Hospital, Beijing 100853,P. R. China.

Background And Objective: Histone deacetylase (HDAC) inhibitors can inhibit cell signal network function through decreasing expression of multiple genes and proteins, thus affect cell proliferation, survival and chemosensitivity. HDAC inhibitors combined with paclitaxel may enhance the inhibitory effect of drugs on lung cancer cells. This study was to observe the synergistic anti-proliferative effect of HDAC inhibitor trichostatin A (TSA) combined with paclitaxel on lung cancer cell lines H322 and H1299, and to investigate its mechanism. Read More

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December 2009
3 Reads

[Feasibility and short-term efficacy of simplified intensity-modulated radiotherapy and concurrent chemotherapy for neck and upper thoracic esophageal carcinoma].

Ai Zheng 2009 Dec;28(12):1265-9

Department of Radiation Oncology,Huai'an First People's Hospital, Huai'an, Jiangsu, 223300,P. R. China.

Background And Objective: For neck and upper thoracic esophageal carcinoma, three dimensional conformal radiation therapy (3D-CRT) does not necessarily meet all clinical requirements while intensity modulated radiation therapy (IMRT) may take up a lot of labour power and material resources. This study was to explore the feasibility of simplified IMPT(sIMRT) and concurrent chemotherapy for neck and upper thoracic esophageal carcinoma, and to investigate the acute toxicities and short-term efficacy of this treatment modality.

Methods: sIMRT plans were designed for 30 patients with neck and upper thoracic esophageal carcinoma. Read More

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December 2009
12 Reads

[Efficacy of surgical resection of left and right transthoracic approaches for middle thoracic esophageal squamous cell carcinoma].

Ai Zheng 2009 Dec;28(12):1260-4

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060,P. R. China.

Background And Objective: For squamous cell carcinoma of the middle thoracic esophagus, surgical resection of left or right transthoracic approach has its advantages and disadvantages, respectively. This study was to compare the outcomes between the two approaches.

Methods: A total of 482 consecutive patients with middle thoracic esophageal squamous cell carcinoma (ESCC) underwent transthoracic esophagectomy between January 1999 and June 2005. Read More

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December 2009
11 Reads

[Relationship between tumor necrosis factor beta gene polymorphism and acute respiratory distress syndrome after operation for esophageal carcinoma].

Ai Zheng 2009 Dec;28(12):1255-9

Intensive Care Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, P. R. China.

Background And Objective: A single nucleotide polymorphism of the tumor necrosis factor beta (TNF-beta) gene affected the level of tumor necrosis factor beta and was associated with prognosis of acute respiratory distress syndrome (ARDS). This study was to investigate the association between the TNF-beta and ARDS after operation for esophageal carcinoma.

Methods: Thirty-four patients with and 116 patients without ARDS after radical resection for thoracotomic esophageal carcinoma were recruited in the Fourth Hospital of Hebei Medical University from January 2005 to June 2007. Read More

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December 2009
11 Reads

[Absorption and elimination of photofrin-II in human immortalization esophageal epithelial cell line SHEE and its malignant transformation cell line SHEEC].

Ai Zheng 2009 Dec;28(12):1248-54

Henan Key Laboratory for Esophageal Cancer, Laboratory for Cancer Research, Basic Medical College, Zhengzhou University, Zhengzhou, Henan, 450052, P. R. China.

Background And Objective: The mechanism of tumor tissues selectively uptake the photosensitizer in photodynamic therapy (PDT) is still unclear. This study was to investigate the affinity of tumor cells to the photosensitizer photofrin-II.

Methods: Ultraviolet spectrophotometer was applied to measure the absorption spectra of various cell culture media. Read More

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December 2009
8 Reads

[Liquid-based cytology for esophageal carcinoma screening].

Ai Zheng 2009 Dec;28(12):1243-7

Department of Pathology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Beijing, 100021, P. R. China.

Background And Objective: Cytologic screening of asymptomatic high risk individuals can detect curable esophageal carcinomas and has been used for several decades. However, the sensitivity of such screening is relatively low, which limits its wide use and development. This study was to investigate the utility of liquid-based cytology in esophageal carcinoma screening. Read More

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December 2009
10 Reads

[Germ-line epimutations and human cancer].

Ai Zheng 2009 Dec;28(12):1236-42

Department of Medical Genetics,Medical School, Nanjing University,Nanjing, Jiangsu 210093, P. R. China.

Epimutations are errors in the normal process of epigenetic regulation which can result in aberrant transcriptional silencing of a normally active gene or reactivation of a normally silent gene. Epimutations are generally considered to be somatic events and to be confined in affected tissues. However, recent studies of patients with hereditary nonpolyposis colorectal cancer (HNPCC) have showed that allele-specific hypermethylation of CpG islands in the promoter region of the MLH1 gene, one of the causes of the tumor, existed in all the tissues examined. Read More

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December 2009
2 Reads

EBV conference establishes goals for defining disease-related EBV subtypes for vaccine development.

Authors:
Laurie Goodman

Ai Zheng 2009 Dec;28(12):1233-5

The 2008 International Association for Research on Epstein-Barr virus and Associated Diseases (IARES) International Epstein-Barr Virus Genome Consortium (IEGC), Guangzhou, China.

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December 2009
3 Reads

Circulating tumor cells and individualized chemotherapy.

Ai Zheng 2009 Nov;28(11):1225-32

The Cancer Center, The Affiliated Drum Tower Hospital, Medical School of Nanjing University Clinical Cancer Institute of Nanjing University, Jiangsu, P. R. China.

Circulating tumor cells (CTC) have been identified in peripheral blood from cancer patients especially those with metastatic lesions. Recently, the analysis of CTC has been developed rapidly and showed good prospects for individualized chemotherapy. The field of CTC research is very important since gene-expression profiling becomes feasible and real time when using CTC as the sample of evaluation. Read More

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November 2009
3 Reads

Research advancement in local ablation therapy for liver cancer.

Ai Zheng 2009 Nov;28(11):1219-24

State Laboratory of Oncology in South China, Guangdong, P. R. China.

After developing for more than 20 years, image-guided local ablation therapy has become one of the major treatments of hepatocellular carcinoma (HCC). In particular, percutaneous radio-frequency ablation has been widely accepted as the first-line treatment of early-stage HCC. A number of randomized controlled trials have shown some differences between these local ablation techniques. Read More

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November 2009
2 Reads

[Metastatic alveolar soft tissue sarcoma of the central nervous system: a clinicopathological analysis of four cases].

Ai Zheng 2009 Nov;28(11):1214-8

Department of Pathology, Linyi Oncology Hospital, Shandong, P. R. China.

Background And Objective: Metastatic alveolar soft tissue sarcoma (ASTS) of the central nervous system is rare and is easy to be misdiagnosed as other primary tumors of central nervous system. This study was to analyze the clinical and pathological features of four patients with ASTS of the central nervous system and to clarify their differential diagnosis as well as prognosis.

Methods: HE slices and clinical data of the four cases were reviewed and immunohistochemical staining was performed. Read More

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November 2009
3 Reads

[Expressions of survivin and the splice variants survivin-2B and survivin-DeltaEx3 in bladder cancer and their clinical significance].

Ai Zheng 2009 Nov;28(11):1209-13

Department of Urology, The First Affiliated Hospital of Soochow University, Jiangsu, P. R. China.

Background And Objective: Studies on survivin over the past 5 years have shown that survivin participates in the genesis of several human cancers, including bladder cancer. Recent studies have indicated that survivin splice variants appeared to have unique subcellular localizations and functions as well. This study was to explore the roles of survivin and its two splice variants survivin-2B and survivin-DeltaEx3 in transitional cell carcinoma of bladder (BTCC). Read More

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November 2009
5 Reads

[Correlation of preoperative neutrophil-to-lymphocyte ratio to prognosis of young patients with hepatocellular carcinoma].

Ai Zheng 2009 Nov;28(11):1203-8

State Key Laboratory of Oncology in South China, Guangdong, P. R. China.

Background And Objective: As an index of inflammation, neutrophil-to-lymphocyte ratio (NLR) is regarded as one of prognostic factors of hepatocellular carcinoma (HCC). This study was to evaluate the correlation of preoperative NLR to the prognosis of young HCC patients after radical resection.

Methods: Clinical data of 91 HCC patients with age of younger than 35 years who underwent radical resection from 2000 to 2005 were analyzed. Read More

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November 2009
9 Reads

[Prognostic significance of natural killer cell infiltration in hepatocellular carcinoma].

Ai Zheng 2009 Nov;28(11):1198-202

School of Life Science, Sun Yat-sen University, Guangdong, P. R. China.

Background And Objective: Several studies have Shown the correlation of high numbers of tumor-infiltrating natural killer (NK) cells with a good prognosis for cancer patients. This study was to investigate the impact of NK cell infiltration on the survival and prognosis of patients with hepatocellular carcinoma (HCC) after resection.

Methods: The proportion of infiltrating NK cells of HCC patients was measured using flow cytometry, and the expression of CD56+ (NK) cells was investigated using immunohistochemistry. Read More

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November 2009
5 Reads

[Influences of lymphatic vessel ligation in pelvic lymphadenectomy on postoperative lymphocyst formation--a randomized controlled trial].

Ai Zheng 2009 Nov;28(11):1193-7

Department of Gynecology and Obstetrics, The Second Affiliated Hospital, Sun Yat-sen University, Guangdong, P. R. China.

Background And Objective: Pelvic lymphocysts are the most common postoperative complications of pelvic lymphadenectomy. Prevention of this disease is more important than treatment. This randomized study was to evaluate the preventive effect of lymph vessel ligation during pelvic lymphadenectomy on pelvic lymphocyst formation. Read More

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November 2009
5 Reads

[Correlation between peripheral blood CD4+CD25high CD127low regulatory T cell and clinical characteristics of patients with non-Hodgkin's lymphoma].

Ai Zheng 2009 Nov;28(11):1186-92

Key Laboratory of Oncology in South China, Guangdong, P. R. China.

Background And Objective: Non-Hodgkin's lymphoma (NHL) is a malignant disease originating from immune system. Studies of the possible relationship between NHL and immune suppression status are of great concern. Regulatory T cell (Treg) is a subtype of T cells that exert an immunosuppressive function. Read More

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November 2009
3 Reads

[Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis].

Ai Zheng 2009 Nov;28(11):1181-5

Department of Gastroenterology, General Hospital of Beijing Military Command, Beijing, P. R. China.

Background And Objective: Long-term use of cyclooxygenase-2 (COX-2) inhibitors can reduce the incidence of digestive cancers, such as colorectal cancers. Proliferating cell nuclear antigen (PCNA) is an important marker of cellular abnormal proliferation. This study was to evaluate the roles and correlation of COX-2 and PCNA in the onset and development of familial adenomatous polyposis (FAP) diseases. Read More

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November 2009
3 Reads

[Effects of E2F-1 overexpression on apoptosis of gastric cancer cells and expressions of apoptosis-related genes].

Ai Zheng 2009 Nov;28(11):1176-80

Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University, Guangxi, P. R. China.

Background And Objective: E2F transcription factor 1 (E2F-1) is an important transcription factor in cell cycle. This study was to investigate the effects of E2F-1 overexpression on apoptosis of gastric cancer MGC-803 cells and expressions of the downstream genes.

Methods: The apoptotic rates were measured by flow cytometry in MGC-803/E2F-1 cells, MGC-803/EV cells or untransfected MGC-803 cells. Read More

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November 2009
1 Read

Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells.

Ai Zheng 2009 Nov;28(11):1168-75

Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

Background And Objective: Elevated expression of matrix metalloproteinases (MMPs) has been found in multiple carcinoma tissues. MMP-26 is highly expressed in prostate and breast cancer tissues, and promotes the invasion of human prostate cancer cells not only through the cleavage of fibronectin and type IV collagen but also by the activation of pro-MMP-9, a powerful gelatinase. This study was to present a comprehensive protein expression profile of MMP-26 in multiple human cancer tissues. Read More

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November 2009
1 Read

[Correlation of XPD gene with susceptibility to gastric cancer].

Ai Zheng 2009 Nov;28(11):1163-7

Department of Digestive Diseases, Medical College, Shandong University, Shandong, P. R. China.

Background And Objective: Mutations in DNA repair system are related to carcinogenesis. This study was to evaluate the correlations of polymorphisms and haplotypes of XPD gene with individual susceptibility to gastric cancer.

Methods: Genomic DNA were extracted from peripheral blood leukocytes of 207 gastric cancer patients and 212 healthy controls. Read More

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November 2009
2 Reads

[Reversal effect of Fe3O4-magnetic nanoparticles on multi-drug resistance of ovarian carcinoma cells and its correlation with apoptosis-associated genes].

Ai Zheng 2009 Nov;28(11):1158-62

Clinical Medical College, Southeast University, Jiangsu, P. R. China.

Background And Objective: Resistance to cisplatin (DDP) remains a major obstacle for the successful treatment of ovarian cancer. This study was to determine the reversal effect of Fe3O4-magnetic nanoparticles (MNPs) on DDP-resistance of ovarian carcinoma cell line SKOV3/DDP, and to explore its correlation with apoptosis-associated genes.

Methods: SKOV3/DDP cells were divided into the DDP group, the Fe3O4-MNPs group, the combination (DDP plus Fe3O4-MNPs) group, and the control group. Read More

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November 2009
4 Reads

[In vitro and in vivo inhibitory effect of Ad-ING4 gene on proliferation of human prostate cancer PC-3 cells].

Ai Zheng 2009 Nov;28(11):1149-57

Cell and Molecular Biology Institute, College of Medicine, Soochow University, Jiangsu, P. R. China.

Background And Objective: Adenovirus vector has been widely used in tumor gene therapy. ING4 is a member of growth inhibiting factors and a potent anti-tumor gene which could induce apoptosis of many tumor cells. This study was to investigate the inhibitory effects of adenovirus-mediated ING4 (Ad-ING4) gene on the proliferation of human prostate cancer PC-3 cells in vitro and in vivo, and to explore its mechanisms. Read More

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November 2009
4 Reads

[Concurrent control study of different radiotherapy for primary nasopharyngeal carcinoma: intensity-modulated radiotherapy versus conventional radiotherapy].

Ai Zheng 2009 Nov;28(11):1143-8

Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Tumor Hospital, Fujian, P. R. China.

Background And Objective: Intensity-modulated radiotherapy (IMRT) has recently gained popularity in the treatment of nasopharyngeal carcinoma (NPC) and improved the local-regional control rate. This study was to explore whether IMRT could improved the survival rate while reduce the radiation-related injury for primary NPC patients compared with conventional radiotherapy (CRT).

Methods: From Nov. Read More

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November 2009
4 Reads

[Short-term efficacy of intensity-modulated radiotherapy on esophageal carcinoma].

Ai Zheng 2009 Nov;28(11):1138-42

Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Hebei, P. R. China.

Background And Objective: Intensity-modulated radiotherapy (IMRT) for esophageal carcinoma has seldom been reported; its clinical efficacy and toxicity are still uncertain. This study was to evaluate the short-term efficacy of IMRT on esophageal carcinoma, and to observe adverse events.

Methods: From June 2006 to March 2008, 37 patients with cervical and thoracic esophageal carcinoma were treated with IMRT. Read More

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November 2009
2 Reads

[Impact of changing gross tumor volume delineation of intensity-modulated radiotherapy on the dose distribution and clinical treatment outcome after induction chemotherapy for the primary locoregionally advanced nasopharyngeal carcinoma].

Ai Zheng 2009 Nov;28(11):1132-7

State Key Laboratory of Oncology in South China, Guangdong, P. R. China.

Background And Objective: The gross tumor volume (GTV) obviously reduces after induction chemotherapy (IC) for primary locoregionally advanced nasopharyngeal carcinoma (NPC). This study was to investigate the impact of changing gross tumor volume delineation on the dose distribution and clinical treatment outcome after IC.

Methods: From January 2008 to April 2009, 24 patients with Stage III-IVb primary locoregionally advanced NPC were treated with TPF regimen IC followed by intensity-modulated radiotherapy (IMRT) with concurrent chemotherapy . Read More

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November 2009
2 Reads

[Dosimetric comparison between intensity-modulated radiotherapy and conformal radiotherapy for upper thoracic esophageal carcinoma].

Ai Zheng 2009 Nov;28(11):1127-31

Department of Radiation Oncology, Cancer Hospital, Shantou University Medical College, Guangdong, P. R. China.

Background And Objective: Treatment planning for radiotherapy of upper thoracic esophageal carcinoma is challenging due to the anatomical features. The difficulty may be resolved by intensity-modulated radiotherapy (IMRT). This study was to compare the dosimetric advantages of IMRT to that of conformal radiotherapy (CRT) for upper thoracic esophageal carcinoma, and to explore the clinical application of IMRT. Read More

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November 2009
1 Read

[Dosimetric comparison between helical tomotherapy and step-and-shoot intensity modulated radiation therapy for endometrial carcinoma].

Ai Zheng 2009 Nov;28(11):1121-6

Department of Radiation Oncology, Cancer Center, Peking University The Third Hospital, Beijing, P. R. China.

Background And Objective: Helical tomotherapy (HT) has shown its dosimetric advantages in the radiotherapy for many cancers. To date, no published studies have performed a dosimetric evaluation of whole pelvic radiotherapy (WPRT) using HT for postoperative endometrial cancer. This study was to compare the dosimetric characteristics of HT and step-and-shoot intensity modulated radiation therapy (SaS-IMRT) for endometrial cancer patients undergoing postoperative WPRT, and to explore whether whole pelvic HT for postoperative endometrial cancer has the advantage of dosimetry. Read More

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November 2009
3 Reads

[Anticancer mechanisms of vitamin E succinate].

Ai Zheng 2009 Oct;28(10):1114-8

Beijing Oriental TenGen Technological Development Co. Ltd., Beijing 100078, P. R. China.

Vitamin E succinate (RRR-alpha-tocopheryl succinate, VES) is an ester derivative of vitamin E. Roles of vitamin E (alpha-tocopherol) family in cancer prevention and therapy have been investigated since 1960s'. Experimental evidences indicated that VES is one of the most effective anticancer compounds of the vitamin E family. Read More

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October 2009

[Progress in chemotherapy for advanced gastric cancer].

Ai Zheng 2009 Oct;28(10):1108-13

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China.

With the rapid development in cytotoxic agents and molecular targeting drugs, some progress in palliative chemotherapy for advanced gastric cancer has been achieved and the median survival of advanced gastric cancer patients is prolonged to about one year. In this review, we summarized the application of new agents, such as docetaxel, paclitaxel, oxaliplatin, irinotecan, capecitabine, S1 and targeting drugs in the treatment of patients with advanced gastric cancer. We focused on the results of phase III clinical trials and concluded that till now no standard regimens for the treatment of advanced gastric cancer are available. Read More

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October 2009
3 Reads

[Placement repeatability of individual oral stent used in radiotherapy of nasopharyngeal carcinoma].

Ai Zheng 2009 Oct;28(10):1103-7

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China.

Background And Objective: Individual oral stent used in nasopharyngeal carcinoma (NPC) patients during radiotherapy can spare the oral mucosa and tongue. This study was to analyze the placement repeatability and feasibility of individual oral stent used in radiotherapy of NPC.

Methods: Individual oral stents were made for 17 naive NPC patients, and three lead markers of 2. Read More

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October 2009

[Expression of survivin mRNA in urine exfoliated cells of patients with bladder transitional cell carcinoma detected by real-time PCR].

Ai Zheng 2009 Oct;28(10):1100-2

Department of Urology, The First Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215006, P. R. China.

Background And Objective: Bladder cancer is the most malignant cancer of the urinary system. However a noninvasive and sensitive method of the early diagnosis for bladder cancer has not been developed. This study was to explore the expression of survivin mRNA in urine exfoliated cells of preoperative and postoperative patients with bladder transitional cell carcinoma (BTCC), and to analyze its value in early diagnosis and postoperative monitoring. Read More

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October 2009
3 Reads

[Clinical analysis of 19 cases of subcutaneous panniculitis T-cell lymphoma with literature review].

Ai Zheng 2009 Oct;28(10):1093-9

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China.

Background And Objective: Subcutaneous panniculitis T-cell lymphoma (SPTCL) is a rare subtype of primary cutaneous lymphoma. This study was to analyze the clinical characteristics, treatment and prognosis of SPTCL.

Methods: Clinical data of 19 SPTCL patients, treated at Cancer Center and the First Affiliated Hospital of Sun Yat-sen University from January 2001 to July 2007, were analyzed. Read More

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October 2009
2 Reads

[Application of anterolateral thigh free flap to reconstruct head and neck soft tissue defects].

Ai Zheng 2009 Oct;28(10):1088-92

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China.

Background And Objective: Although anterolateral thigh (ALT) flap has the advantage of limited damage to the donor site, its clinical application is not common. This study was to study the clinical value of ALT flap in the reconstruction of head and neck soft tissue defects.

Methods: Twenty patients receiving reconstruction of head and neck soft tissue defects using ALT flap at Sun Yat-sen University Cancer Center between November 2004 and May 2008 were retrospectively reviewed. Read More

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October 2009
4 Reads

[Efficacy of modified Hyper-CVAD regimen on non-Hodgkin's lymphoma and safety evaluation].

Ai Zheng 2009 Oct;28(10):1083-7

Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, P. R. China.

Background And Objective: The efficacy of standard chemotherapy regimen on aggressive non-Hodgkin's lymphoma (NHL) of certain pathologic types is unsatisfied. This study was to evaluate the safety and efficacy of modified Hyper-CVAD regimen on Chinese patients with aggressive NHL.

Methods: Clinical records of 31 NHL patients who received modified Hyper-CVAD regimen in Cancer Hospital of Chinese Academy of Medical Sciences from June 2004 to June 2008 were analyzed in terms of toxicity and response. Read More

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October 2009
10 Reads

[Radiotherapy for and prognosis of breast cancer patients with local-regional recurrence after mastectomy].

Ai Zheng 2009 Oct;28(10):1077-82

Department of Radiation Oncology, Cancer Hospital, Fudan University, Shanghai 20032, P.R.China.

Background And Objective: Controversies remain regarding the therapeutic principle for and prognosis of breast cancer patients with isolated local-regional recurrence after mastectomy. This study was to evaluate the role of radiotherapy in treating these patients and to investigate the prognosis.

Methods: Clinical data of 255 breast cancer patients with chest-wall and/or regional lymph node recurrence as first failure after mastectomy from 1990 to 2005 were analyzed. Read More

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October 2009
1 Read

[Ezrin and inducible nitric oxide synthase in malignant proliferation of salivary gland pleomorphic adenoma].

Ai Zheng 2009 Oct;28(10):1072-6

Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, P. R. China.

Background And Objective: Ezrin and inducible nitric oxide synthase (iNOS) may play an important role in regulating tumor proliferation, invasion, and metastasis. This study was to investigate the expression of Ezrin and iNOS and their correlation to malignant proliferation of salivary gland pleomorphic adenoma (PA).

Methods: Expressions of Ezrin, iNOS and nuclear Ki-67 antigen were detected by immunohistochemistry in common type (n=40), active type (n=25) and malignant (n=11) pleomorphic adenoma. Read More

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October 2009
9 Reads

[Dendritic cell-tumor cell fusion vaccine prevents growth of subcutaneous transplanted esophageal carcinomas].

Ai Zheng 2009 Oct;28(10):1067-71

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China.

Background And Objective: Our previous studies have shown that dendritic cell (DC)-tumor cell fusion vaccine can induce specific antitumor response against esophageal carcinoma cells. This study was to investigate the inhibitory effect of intratumor injection of the antigen-specific cytotoxic T lymphocytes (CTLs) induced by DC-tumor cell fusion vaccine against subcutaneously transplanted esophageal carcinoma cells in nude mice, and to analyze the influence of DC/tumor cell fusion vaccine on proliferation and apoptosis of esophageal carcinoma cells.

Methods: Fusion cell vaccine of mature DCs with EC109 cells were generated by the polyethylene glycol (PEG) protocol and the antigen-specific CTLs were induced. Read More

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October 2009
4 Reads

[Inhibitory effect of novel internalized fully human phage antibody fragments on proliferation of lung adenocarcinoma cell line overexpressing peroxiredoxin I].

Ai Zheng 2009 Oct;28(10):1061-6

Department of Radiation Medicine, Chongqing Medical University, Chongqing 400016, P. R. China.

Background And Objective: Previous researches have implicated the close relationship between peroxiredoxin I (Prx I) and cancer progression. A lung adenocarcinoma-related human phage antibody library has been constructed by using phage display techniques. This study was to screen out the single chain variable fragment (scFv) antibodies from the library against a lung adenocarcinoma cell line overexpressing Prx I and to analyze their anti-proliferation ability. Read More

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October 2009
1 Read