883,638 results match your criteria Ai Edam-artificial Intelligence For Engineering Design Analysis And Manufacturing[Journal]


Rheological properties of Prunus persica exudate: Potential effects of proteins and polyphenols.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Shanghai Engineering Research Center of Food Microbiology, School of Medical Instruments and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:

This study was to investigate the rheological properties of graded Prunus persica exudates (peach gums). Graded peach gums were extracted by hot water and precipitated by ethanol to obtain white peach gum polysaccharide (WPGP) and yellow peach gum polysaccharide (YPGP). Chemical analysis showed that YPGP had 0. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.104DOI Listing

Ontogenetic development of gonads and external sexual characters of the protandric simultaneous hermaphrodite peppermint shrimp, Lysmata vittata (Caridea: Hippolytidae).

PLoS One 2019 19;14(4):e0215406. Epub 2019 Apr 19.

College of Ocean and Earth Sciences, Xiamen University, Xiamen, China.

The peppermint shrimp Lysmata vittata (Caridea: Hippolytidae) is a marine caridean shrimp popular in marine aquarium trade. The species is known to display the sexual system of protandric simultaneous hermaphrodite. In this study, based on captive bred specimens, the complete ontogenetic gonad development of L. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215406PLOS

Mini-Review: The Non-Immune Functions of Toll-Like Receptors.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):37-45

Department of Pharmacology, Zhejiang University of Technology, 18# Chaowang Road, Hangzhou City, Zhejiang Province 310014, P.R. China.

Toll-like receptors (TLRs) are a family of highly conserved pattern recognition receptors that can recognize both pathogen-associated molecular patterns and danger-associated molecular patterns. These receptors are important in the activation of the innate immune system and play a role in shaping the adaptive immune system. For years, the expression of TLRs in the brain has been proposed to contribute to the immunological protection of the central nervous system. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018027399DOI Listing
January 2019

Developing a new intelligent system for the diagnosis of oral medicine with case-based reasoning approach.

Oral Dis 2019 Apr 19. Epub 2019 Apr 19.

Department of Oral and Maxillofacial Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Since the clinical manifestations of many oral diseases can be quite similar despite the wide variety in etiology and pathology, the differential diagnosis of oral diseases is a complex and challenging process. Intelligent system for differential diagnosis of oral medicine using the artificial intelligence (AI) capabilities, helps specialists in achieving differential diagnosis in a wide range of oral diseases.

Materials And Methods: First, the essential data elements to design and develop an intelligent system were identified in a cross-sectional descriptive study. Read More

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http://dx.doi.org/10.1111/odi.13108DOI Listing

A ratio-based method to identify true biomarkers by normalizing circulating ncRNA sequencing and quantitative PCR data.

Anal Chem 2019 Apr 19. Epub 2019 Apr 19.

Recent studies have indicated that circulating noncoding RNAs (ncRNAs) such as miRNAs are stable biomarkers for the diagnosis and prognosis of human diseases. However, due to low concentration of circulating ncRNAs in blood, data normalization in plasma/serum ncRNA experiments using next-generation sequencing and quantitative real time RT-qPCR is a challenge. We found that the current normalization methods based on synthetic external spiked-in controls or published endogenous miRNA controls are inappropriate as they are not stably expressed and therefore, fails to reliably detect differentially expressed ncRNAs. Read More

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http://dx.doi.org/10.1021/acs.analchem.9b00821DOI Listing

IL-10 inhibits apoptosis in brain tissue around the hematoma after ICH by inhibiting proNGF.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3005-3011

Department of Geratology, Yantai Yuhuangding Hospital, Yantai, China.

Objective: To explore the roles of interleukin-10 (IL-10), proNGF and p75NTR in apoptosis of brain tissues induced by intracerebral hemorrhage (ICH).

Patients And Methods: According to the time of sample collection after ICH, brain tissue samples were divided into < 6 h group, 6-24 h group (including 24 h), 24-72 h group (including 72 h) and > 72 h group. Meanwhile, 10 tissues that dropped from the beginning at the cortical stoma (distal part of the hematoma) were harvested as controls. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17582DOI Listing

[Development of an ELISA-based high throughput screening method for novel anticancer agents targeting β-catenin/Lef1 interaction].

Sheng Wu Gong Cheng Xue Bao 2019 Apr;35(4):707-717

Center for New Drug Screening & Evaluation, School of Pharmacy, Wannan Medical College, Wuhu 241002, Anhui, China.

To develop an enzyme-linked immunosorbent assay (ELISA)-based high throughput screening (HTS) method for β-catenin/Lef1 interaction antagonists screening, Escherichia coli Rosetta (DE3) competent cells were transformed with β-catenin-pET-30a(+) plasmid. β-catenin protein was expressed after induction and purified using affinity chromatography. The biological activity of purified β-catenin was further analyzed by GST Pulldown assay. Read More

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http://dx.doi.org/10.13345/j.cjb.180344DOI Listing

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Endometrial Cancer Cell Proliferation and Migration through Delivery of Exogenous miR-302a.

Stem Cells Int 2019 14;2019:8108576. Epub 2019 Mar 14.

Department of Obstetrics and Gynecology, The First Affiliated Hospital, Key laboratory of Follicular Development and Reproductive Health of Liaoning Province, Jinzhou Medical University, Jinzhou, Liaoning 121001, China.

MicroRNAs (miRNAs) are potential therapeutic targets in endometrial cancer, but the difficulties associated with their delivery to tumor target cells have hampered their applications. Human umbilical cord mesenchymal stem cells (hUCMSCs) have a well-recognized tumor-homing ability, emphasizing the capacity of tumor-targeted delivery of extracellular vesicles. hUCMSCs release extracellular vesicles rich in miRNAs, which play a vital role in intercellular communication. Read More

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http://dx.doi.org/10.1155/2019/8108576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437733PMC

Evaluation of Placental Perfusion Based on Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) and Its Predictive Value for Late-Onset Fetal Growth Restriction.

Geburtshilfe Frauenheilkd 2019 Apr 12;79(4):396-401. Epub 2018 Dec 12.

Department of Medical Image, Guangzhou Women and Children's Medical Center, Guangzhou, China.

The aim of this study was to investigate placental blood perfusion in middle and late pregnancy and explore its predictive value for fetal growth restriction (FGR). All pregnant women included in the study were examined using placental intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI). Three IVIM parameters (D, f, D*) were obtained for each pregnant woman and analyzed using Image J software. Read More

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http://dx.doi.org/10.1055/a-0717-5275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461467PMC

How to develop machine learning models for healthcare.

Nat Mater 2019 May;18(5):410-414

Google AI Healthcare, Mountain View, CA, USA.

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http://dx.doi.org/10.1038/s41563-019-0345-0DOI Listing

Clinical Measures Related to Forward Shoulder Posture: A Reliability and Correlational Study.

J Manipulative Physiol Ther 2019 Apr 15. Epub 2019 Apr 15.

Graduate Program in Rehabilitation Sciences, Department of Physical Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Objectives: The purpose of this study was to examine the reliability of clinical measures related to forward shoulder posture (pectoralis minor index [PMI], scapular index [SI], abduction index [AI], acromion to the wall index [AWI] acromion to the treatment table index [ATI], and thoracic curvature [TC]), and to investigate the association (redundancy) among these measures.

Methods: Twenty-one asymptomatic participants participated in this study. Two physiotherapists were trained to perform the clinical measurements. Read More

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http://dx.doi.org/10.1016/j.jmpt.2019.03.006DOI Listing

Cooperation of lactic acid bacteria regulated by the AI-2/LuxS system involve in the biopreservation of refrigerated shrimp.

Food Res Int 2019 Jun 14;120:679-687. Epub 2018 Nov 14.

College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao 266003, China. Electronic address:

Litopenaeus vannamei is an extremely perishable food because of rapid microbial growth and chemical degradation after harvesting. Biopreservation is a food preservation technology based on the addition of "positive" bacteria to kill or prevent the growth of undesirable microorganisms. In this study, the cooperation between lactic acid bacteria (LAB) strains (Lactobacillus plantarum AB-1 and Lactobacillus casei) regulated by the AI-2/LuxS was investigated in vitro and on shrimp. Read More

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http://dx.doi.org/10.1016/j.foodres.2018.11.025DOI Listing

Grinding levels of raspberry pomace affect intestinal microbial activity, lipid and glucose metabolism in Wistar rats.

Food Res Int 2019 Jun 8;120:399-406. Epub 2019 Mar 8.

Research Institute of Horticulture, Konstytucji 3 Maja 1/3, 96-100 Skierniewice, Poland.

This study presents the effect of raspberry pomace and its grinding level on microbial activity in the gastrointestinal tract as well as on the parameters involved in the regulation of lipid and glucose metabolism in Wistar rats. The nutritional experiment was performed using 24 male Wistar rats, which were divided into 3 groups of 8 animals each. The animals were fed a standard diet (C) or a modified diet containing 7% raspberry pomace subjected to standard (SG) or fine (FG) grinding. Read More

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http://dx.doi.org/10.1016/j.foodres.2019.03.014DOI Listing

Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer.

Mol Cancer 2019 Apr 18;18(1):89. Epub 2019 Apr 18.

Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150081, China.

Background: The biology function of antisense intronic long noncoding RNA (Ai-lncRNA) is still unknown. Meanwhile, cancer patients with paclitaxel resistance have limited therapeutic options in the clinic. However, the potential involvement of Ai-lncRNA in paclitaxel sensitivity remains unclear in human cancer. Read More

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http://dx.doi.org/10.1186/s12943-019-1017-zDOI Listing

Associations of airway tree to lung volume ratio on computed tomography with lung function and symptoms in chronic obstructive pulmonary disease.

Respir Res 2019 Apr 18;20(1):77. Epub 2019 Apr 18.

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Decreased airway lumen size and increased lung volume are major structural changes in chronic obstructive pulmonary disease (COPD). However, even though the outer wall of the airways is connected with lung parenchyma and the mechanical properties of the parenchyma affect the behaviour of the airways, little is known about the interactions between airway and lung sizes on lung function and symptoms. The present study examined these effects by establishing a novel computed tomography (CT) index, namely, airway volume percent (AWV%), which was defined as a percentage ratio of the airway tree to lung volume. Read More

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http://dx.doi.org/10.1186/s12931-019-1047-5DOI Listing

EvolStruct-Phogly: incorporating structural properties and evolutionary information from profile bigrams for the phosphoglycerylation prediction.

BMC Genomics 2019 Apr 18;19(Suppl 9):984. Epub 2019 Apr 18.

Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Background: Post-translational modification (PTM), which is a biological process, tends to modify proteome that leads to changes in normal cell biology and pathogenesis. In the recent times, there has been many reported PTMs. Out of the many modifications, phosphoglycerylation has become particularly the subject of interest. Read More

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http://dx.doi.org/10.1186/s12864-018-5383-5DOI Listing

Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer.

BMC Bioinformatics 2019 Apr 18;20(Suppl 4):119. Epub 2019 Apr 18.

geneXplain GmbH, 38302, Wolfenbüttel, Germany.

Background: The search for molecular biomarkers of early-onset colorectal cancer (CRC) is an important but still quite challenging and unsolved task. Detection of CpG methylation in human DNA obtained from blood or stool has been proposed as a promising approach to a noninvasive early diagnosis of CRC. Thousands of abnormally methylated CpG positions in CRC genomes are often located in non-coding parts of genes. Read More

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http://dx.doi.org/10.1186/s12859-019-2687-7DOI Listing

Spatial quorum sensing modelling using coloured hybrid Petri nets and simulative model checking.

BMC Bioinformatics 2019 Apr 18;20(Suppl 4):173. Epub 2019 Apr 18.

Computer Science Department, Brandenburg University of Technology Cottbus-Senftenberg, Cottbus, D-03046, Germany.

Background: Quorum sensing drives biofilm formation in bacteria in order to ensure that biofilm formation only occurs when colonies are of a sufficient size and density. This spatial behaviour is achieved by the broadcast communication of an autoinducer in a diffusion scenario. This is of interest, for example, when considering the role of gut microbiota in gut health. Read More

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http://dx.doi.org/10.1186/s12859-019-2690-zDOI Listing

Artificial Intelligence (AI) for the early detection of breast cancer: a scoping review to assess AI's potential in breast screening practice.

Expert Rev Med Devices 2019 Apr 18. Epub 2019 Apr 18.

b Department of Radiology, University of Washington School of Medicine; Department of Health Services , University of Washington School of Public Health; Hutchinson Institute for Cancer Outcomes Research , 1144 Eastlake Avenue East LG-212, Seattle , WA 98109 , USA.

Introduction: Various factors are driving interest in the application of artificial intelligence (AI) for breast cancer (BC) detection, but it is unclear whether the evidence warrants large-scale use in population-based screening. Areas covered: We performed a scoping review, a structured evidence synthesis describing a broad research field, to summarise knowledge on AI evaluated for BC detection and to assess AI's readiness for adoption in BC screening. Studies were predominantly small retrospective studies based on highly selected image datasets that contained a high proportion of cancers (median BC proportion in datasets 26. Read More

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http://dx.doi.org/10.1080/17434440.2019.1610387DOI Listing

Non-conventional compounds with potential therapeutic effects against Alzheimer's disease.

Expert Rev Neurother 2019 Apr 19. Epub 2019 Apr 19.

a Laboratory of Molecular Modeling, Department of Chemistry , Federal University of Lavras , Lavras/MG , 37200-000 , Brazil.

Introduction: Alzheimer's disease (AD) is the most common cause of dementia. Clinical progress in this pathogenesis field has drawn the attention of researchers, stimulating the investigation of novel treatment methods. Current therapies that deal with cholinesterase inhibitors and/or NMDA antagonists have shown a modest symptomatic potential, increasing the need for research into more efficient therapeutics. Read More

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http://dx.doi.org/10.1080/14737175.2019.1608823DOI Listing

Experimental Vertical Transmission of Chikungunya Virus by Brazilian and Florida Populations.

Viruses 2019 Apr 17;11(4). Epub 2019 Apr 17.

University of Florida, IFAS, Department of Entomology and Nematology, Florida Medical Entomology Laboratory, Vero Beach, FL 32962, USA.

Chikungunya virus (CHIKV) is a vector-borne alphavirus transmitted by the bites of mosquitoes, specifically infected, female mosquitoes of the invasive species. In nature, CHIKV can be maintained by vertical transmission, a phenomenon that relates to the transfer of CHIKV from the infected parent to their offspring within the ovary or during oviposition. In the present study, we conducted laboratory experiments to determine vertical transmission with populations from Brazil and Florida. Read More

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http://dx.doi.org/10.3390/v11040353DOI Listing

Mitovirus and Mitochondrial Coding Sequences from Basal Fungus .

Viruses 2019 Apr 17;11(4). Epub 2019 Apr 17.

Department of Plant and Environmental Sciences, University of Copenhagen, DK-1871 Frederiksberg, Denmark.

Fungi constituting the species complex (members of subphylum , phylum ) commonly kill their insect hosts and manipulate host behaviors in the process. In this study, we made use of public transcriptome data to identify and characterize eight new species of mitoviruses associated with several different isolates. Mitoviruses are simple RNA viruses that replicate in host mitochondria and are frequently found in more phylogenetically apical fungi (members of subphylum , phylum , phylum and phylum ) as well as in plants. Read More

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http://dx.doi.org/10.3390/v11040351DOI Listing

Reinforcement learning meets minority game: Toward optimal resource allocation.

Phys Rev E 2019 Mar;99(3-1):032302

School of Electrical, Computer and Energy Engineering, Department of Physics, Arizona State University, Tempe, Arizona 85287, USA.

The main point of this paper is to provide an affirmative answer through exploiting reinforcement learning (RL) in artificial intelligence (AI) for eliminating herding without any external control in complex resource allocation systems. In particular, we demonstrate that when agents are empowered with RL (e.g. Read More

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http://dx.doi.org/10.1103/PhysRevE.99.032302DOI Listing

Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting.

JAMA Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute/Harvard Medical School, Boston, Massachusetts.

Importance: Radiation therapy (RT) is a critical cancer treatment, but the existing radiation oncologist work force does not meet growing global demand. One key physician task in RT planning involves tumor segmentation for targeting, which requires substantial training and is subject to significant interobserver variation.

Objective: To determine whether crowd innovation could be used to rapidly produce artificial intelligence (AI) solutions that replicate the accuracy of an expert radiation oncologist in segmenting lung tumors for RT targeting. Read More

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http://dx.doi.org/10.1001/jamaoncol.2019.0159DOI Listing

Artificial intelligence and the analysis of multi-platform metabolomics data for the detection of intrauterine growth restriction.

PLoS One 2019 18;14(4):e0214121. Epub 2019 Apr 18.

Department of Obstetrics and Gynecology, William Beaumont Health, Royal Oak, MI, United States of America.

Objective: To interrogate the pathogenesis of intrauterine growth restriction (IUGR) and apply Artificial Intelligence (AI) techniques to multi-platform i.e. nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) based metabolomic analysis for the prediction of IUGR. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214121PLOS

XGBoost Model for Chronic Kidney Disease Diagnosis.

IEEE/ACM Trans Comput Biol Bioinform 2019 Apr 17. Epub 2019 Apr 17.

Chronic Kidney Disease (CKD) is a menace that is affecting 10% of the world population and 15% of the South African population. The early and cheap diagnosis of this disease with accuracy and reliability will save 20,000 lives in South Africa per year. Scientists are developing smart solutions with Artificial Intelligence (AI). Read More

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https://ieeexplore.ieee.org/document/8693581/
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http://dx.doi.org/10.1109/TCBB.2019.2911071DOI Listing
April 2019
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Vision loss with pembrolizumab treatment: A report of two cases.

J Oncol Pharm Pract 2019 Apr 18:1078155219841683. Epub 2019 Apr 18.

University of Kansas Medical Center, Kansas City, KS.

Background: Vision loss and other ocular toxicities are rare, but detrimental, side effects of immune checkpoint inhibitors. Herein, we report two patients who developed vision loss while on pembrolizumab treatment.

Cases Presentation: Case 1 - A 58-year-old man was started on pembrolizumab for advanced melanoma. Read More

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http://dx.doi.org/10.1177/1078155219841683DOI Listing
April 2019
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Second prostaglandin F2α treatment during Ovsynch protocol does not improve fertility outcomes in dairy cows.

Pol J Vet Sci 2019 Mar;22(1):157-161

Department of Animal Reproduction with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 14, 10-719 Olsztyn, Poland.

The objective of this study was to evaluate the effect of a second prostaglandin F2α (PGF2α) treatment during Ovsynch on luteal regression and fertility in dairy cows, compared with standard Ovsynch. The study was conducted on 111 Holstein Friesian multiparous cows on commercial dairy farm. The cows in the experimental group (n=48) received two treatments of PGF2α 24 hours apart during Ovsynch. Read More

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http://dx.doi.org/10.24425/pjvs.2018.125615DOI Listing

Artificial Intelligence and Optical Coherence Tomography Imaging.

Asia Pac J Ophthalmol (Phila) 2019 Apr 18. Epub 2019 Apr 18.

Harkness Eye Institute, Columbia University, New York, United States.

This review article aimed to highlight the application and use of artificial intelligence (AI) in optical coherence tomography (OCT) imaging in ophthalmology. Artificial intelligence programs seek to simulate intelligent human behavior in computers. With an abundance of patient data, especially with the advent and growing use of imaging modalities such as OCT, AI programs provide us with the unique opportunity to analyze this plethora of information and assist in making clinical decisions in the field of ophthalmology. Read More

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http://www.apjo.org/Apjo/pdf/id/654.html
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http://dx.doi.org/10.22608/APO.201904DOI Listing
April 2019
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Female Sex Workers' Experiences Selling Sex during Pregnancy and Post-Delivery in South Africa.

Stud Fam Plann 2019 Apr 17. Epub 2019 Apr 17.

Nearly 75 percent of female sex workers (FSWs) in Port Elizabeth, South Africa are mothers, many of whom engage in sex work during pregnancy or after delivery. We conducted in-depth interviews with 22 postpartum and 8 pregnant FSWs in Port Elizabeth. Interview guides were used to probe women's experiences, challenges, and concerns about selling sex during pregnancy and post-delivery in a high-HIV-prevalence context. Read More

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http://dx.doi.org/10.1111/sifp.12090DOI Listing

Acupuncture and Vitamin D for the Management of Aromatase Inhibitor-Induced Arthralgia.

Curr Oncol Rep 2019 Apr 17;21(6):51. Epub 2019 Apr 17.

Houston Methodist Cancer Center/Weill Cornell Medicine, Outpatient Tower, Floor 24, 6445 Main Street, Houston, TX, 77030, USA.

Purpose Of Review: Aromatase inhibitor-induced arthralgia (AIA) is a very common syndrome which significantly affects breast cancer survivors' quality of life, and it often leads to non-compliance with aromatase inhibitor (AI) therapy. However, the treatment of AIA remains a clinical challenge. Here, we will review the current data for acupuncture and vitamin D in the management of AIA. Read More

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http://link.springer.com/10.1007/s11912-019-0795-1
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http://dx.doi.org/10.1007/s11912-019-0795-1DOI Listing
April 2019
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Experimental study of a new original mesh developed for pelvic floor reconstructive surgery.

Int Urogynecol J 2019 Apr 17. Epub 2019 Apr 17.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No.1 Shuai Fu Road, Dongcheng District, Beijing, People's Republic of China.

Introduction And Hypothesis: Most synthetic meshes used in transvaginal surgery are made of polypropylene, which has a stable performance, but does not easily degrade in vivo. However, mesh-related complications are difficult to address and have raised serious concerns. A new biomaterial mesh with good tissue integration and few mesh-related complications is needed. Read More

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http://link.springer.com/10.1007/s00192-019-03947-4
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http://dx.doi.org/10.1007/s00192-019-03947-4DOI Listing
April 2019
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Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents.

ACS Med Chem Lett 2019 Apr 14;10(4):499-503. Epub 2019 Jan 14.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Roma, Italy.

Targeted approaches aiming at modulating NHERF1 activity, rather than its overall expression, would be preferred to preserve the normal functions of this versatile protein. We focused our attention on the NHERF1/PDZ1 domain that governs its membrane recruitment/displacement through a transient phosphorylation switch. We herein report the design and synthesis of novel NHERF1 PDZ1 domain inhibitors. Read More

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00532
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http://dx.doi.org/10.1021/acsmedchemlett.8b00532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466550PMC
April 2019
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Reliability of the sourcil method of acetabular index measurement in developmental dysplasia of the hip.

J Child Orthop 2019 Apr;13(2):167-171

The Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: The ability to monitor and study developmental dysplasia of the hip (DDH) requires validated radiographic outcome measures. The sourcil method of acetabular index measurement (AI-S) has not yet been shown to be a reliable measure of acetabular dysplasia in a DDH population, despite its widespread use. The aims of this study were to test the reliability of the AI-S method in a DDH population, and to compare the reliability of the AI-S method with that of the classic lateral edge method (AI-L). Read More

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http://dx.doi.org/10.1302/1863-2548.13.190015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442514PMC

Feasibility of artificial intelligence for predicting live birth without aneuploidy from a blastocyst image.

Reprod Med Biol 2019 Apr 19;18(2):204-211. Epub 2019 Feb 19.

Okayama Couple's Clinic Okayama City Japan.

Purpose: To make the artificial intelligence (AI) classifiers of the image of the blastocyst implanted later in order to predict the probability of achieving live birth.

Methods: A system for using the machine learning approaches, which are logistic regression, naive Bayes, nearest neighbors, random forest, neural network, and support vector machine, of artificial intelligence to predict the probability of live birth from a blastocyst image was developed. Eighty images of blastocysts that led to live births and 80 images of blastocysts that led to aneuploid miscarriages were used to create an AI-based method with 5-fold cross-validation retrospectively for classifying embryos. Read More

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http://dx.doi.org/10.1002/rmb2.12267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452008PMC

Feasibility of deep learning for predicting live birth from a blastocyst image in patients classified by age.

Reprod Med Biol 2019 Apr 1;18(2):190-203. Epub 2019 Mar 1.

Okayama Couple's Clinic Okayama City Japan.

Purpose: To identify artificial intelligence (AI) classifiers in images of blastocysts to predict the probability of achieving a live birth in patients classified by age. Results are compared to those obtained by conventional embryo (CE) evaluation.

Methods: A total of 5691 blastocysts were retrospectively enrolled. Read More

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http://dx.doi.org/10.1002/rmb2.12266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452012PMC

CARD9 microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment.

Nat Immunol 2019 05 17;20(5):559-570. Epub 2019 Apr 17.

Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

The C-type lectin receptor-Syk (spleen tyrosine kinase) adaptor CARD9 facilitates protective antifungal immunity within the central nervous system (CNS), as human deficiency in CARD9 causes susceptibility to fungus-specific, CNS-targeted infection. CARD9 promotes the recruitment of neutrophils to the fungus-infected CNS, which mediates fungal clearance. In the present study we investigated host and pathogen factors that promote protective neutrophil recruitment during invasion of the CNS by Candida albicans. Read More

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http://www.nature.com/articles/s41590-019-0377-2
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http://dx.doi.org/10.1038/s41590-019-0377-2DOI Listing
May 2019
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NDV-3A vaccination prevents C. albicans colonization of jugular vein catheters in mice.

Sci Rep 2019 Apr 17;9(1):6194. Epub 2019 Apr 17.

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

NDV-3A, a novel fungal vaccine undergoing clinical trials, contains a recombinant version of the Candida albicans rAls3 N-terminus protein (rAls3p-N) in aluminum hydroxide. In a Phase 1b/2a clinical trial, NDV-3A protected women from recurrent vulvovaginal candidiasis. Here, we reveal that active immunization in mice with NDV-3A induces high titers of anti-rAls3p-N antibodies that interfere with C. Read More

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http://www.nature.com/articles/s41598-019-42517-y
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http://dx.doi.org/10.1038/s41598-019-42517-yDOI Listing
April 2019
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Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.

Sci Rep 2019 Apr 17;9(1):6206. Epub 2019 Apr 17.

Division of Allergy & Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full thickness human donor esophagi to create and validate the ex vivo function of mucosa and smooth muscle (n = 25). Explanted tissue was tested for contractile responses to carbachol and histamine. Read More

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http://dx.doi.org/10.1038/s41598-019-41147-8DOI Listing

Hospital-derived antibody profiles of malaria patients in Southwest India.

Malar J 2019 Apr 17;18(1):138. Epub 2019 Apr 17.

Department of Chemistry and Department of Global Health, University of Washington, Seattle, WA, 98195, USA.

Background: Naturally acquired immunity to malaria across the globe varies in intensity and protective powers. Many of the studies on immunity are from hyperendemic regions of Africa. In Asia, particularly in India, there are unique opportunities for exploring and understanding malaria immunity relative to host age, co-occurrence of Plasmodium falciparum and Plasmodium vivax infections, varying travel history, and varying disease severity. Read More

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http://dx.doi.org/10.1186/s12936-019-2771-5DOI Listing

Design of Poly(lactic--glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis.

Pharmaceutics 2019 Apr 16;11(4). Epub 2019 Apr 16.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Long-acting topical products for pre-exposure prophylaxis (PrEP) that combine antiretrovirals (ARVs) inhibiting initial stages of infection are highly promising for prevention of HIV sexual transmission. We fabricated core-shell poly(lactide--glycolide) (PLGA) nanoparticles, loaded with two potent ARVs, griffithsin (GRFT) and dapivirine (DPV), having different physicochemical properties and specifically targeting the fusion and reverse transcription steps of HIV replication, as a potential long-acting microbicide product. The nanoparticles were evaluated for particle size and zeta potential, drug release, cytotoxicity, cellular uptake and in vitro bioactivity. Read More

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http://dx.doi.org/10.3390/pharmaceutics11040184DOI Listing

The Immunobiology of the Interleukin-12 Family: Room for Discovery.

Immunity 2019 Apr;50(4):851-870

Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 West Markham St., Little Rock, AR 72205, USA. Electronic address:

The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family members utilize shared receptors and cytokine subunits and influence the outcome of cancer, infection, and inflammatory diseases. Consequently, many facets of their biology are being therapeutically targeted. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472917PMC
April 2019
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The γ Family of Cytokines: Basic Biology to Therapeutic Ramifications.

Immunity 2019 Apr;50(4):832-850

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Metabolic, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1674, USA. Electronic address:

The common cytokine receptor γ chain, γ, is a component of the receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ results in X-linked severe combined immunodeficiency in humans, and γ family cytokines collectively regulate development, proliferation, survival, and differentiation of immune cells. Here, we review the basic biology of these cytokines, highlighting mechanisms of signaling and gene regulation that have provided insights for immunodeficiency, autoimmunity, allergic diseases, and cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193014
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http://dx.doi.org/10.1016/j.immuni.2019.03.028DOI Listing
April 2019
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Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 04;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

Background: Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B cells, and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy with γ-retroviral vectors failed to reconstitute B-cell and NK-cell immunity and was complicated by vector-related leukemia.

Methods: We performed a dual-center, phase 1-2 safety and efficacy study of a lentiviral vector to transfer complementary DNA to bone marrow stem cells after low-exposure, targeted busulfan conditioning in eight infants with newly diagnosed SCID-X1. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1815408
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http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing
April 2019
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Coverage of ethics within the artificial intelligence and machine learning academic literature: The case of disabled people.

Assist Technol 2019 Apr 17:1-7. Epub 2019 Apr 17.

a Community Rehabilitation and Disability Studies, Department of Community Health Sciences, Cumming School of Medicine , University of Calgary , Calgary , Alberta , Canada.

Disabled people are often the anticipated users of scientific and technological products and processes advanced and enabled by artificial intelligence (AI) and machine learning (ML). Disabled people are also impacted by societal impacts of AI/ML. Many ethical issues are identified within AI/ML as fields and within individual applications of AI/ML. Read More

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http://dx.doi.org/10.1080/10400435.2019.1593259DOI Listing

Triterpenoids from Ganoderma lucidum and their Potential Anti-inflammatory Effects.

J Agric Food Chem 2019 Apr 17. Epub 2019 Apr 17.

Ganoderma lucidum, as food, tea, dietary supplement, and medicine, is widely used in China and Eastern Asian countries. In order to discover its anti-inflammatory constituents and provide some references for the usage of G. lucidum and G. Read More

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http://pubs.acs.org/doi/10.1021/acs.jafc.9b01195
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http://dx.doi.org/10.1021/acs.jafc.9b01195DOI Listing
April 2019
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Production of l-Ribulose Using an Encapsulated l-Arabinose Isomerase in Yeast Spores.

J Agric Food Chem 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology , Jiangnan University , Wuxi , Jiangsu 214122 , People's Republic of China.

The rare sugar l-ribulose is produced from the abundant sugar l-arabinose by enzymatic conversion. An l-arabinose isomerase (AI) from Geobacillus thermodenitrificans was efficiently expressed and encapsulated in Saccharomyces cerevisiae spores. Deletion of the yeast OSW2 gene, which causes a mild defect in the integrity of the spore wall, substantially improved the activity of encapsulated AI, without damaging its superior enzymatic properties of thermostability, pH tolerance,and resistance toward SDS and proteinase treatments. Read More

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http://pubs.acs.org/doi/10.1021/acs.jafc.9b00640
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http://dx.doi.org/10.1021/acs.jafc.9b00640DOI Listing
April 2019
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Prevalence of Hip Dysplasia and Associated Conditions in Children Treated for Idiopathic Early-onset Scoliosis-Don't Just Look at the Spine.

J Pediatr Orthop 2019 Apr 15. Epub 2019 Apr 15.

Shriners Hospitals for Children Salt Lake City.

Background: Hip dysplasia, congenital muscular torticollis, plagiocephaly, and metatarsus adductus are known to be associated. The etiology of infantile idiopathic scoliosis and its association with the aforementioned conditions is unknown. This study reviews a series of infantile scoliosis patients to address this gap. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001390DOI Listing

[Effects of aerated irrigation on CO and NO emission from protected melon soils under different nitrogen application levels].

Ying Yong Sheng Tai Xue Bao 2019 Apr;30(4):1319-1326

Ministry of Education Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas, Northwest A&F University, Yangling 712100, Shaanxi, China.

To reveal the effects of coupling nitrogen (N) application and aerated irrigation on soil CO and NO emission, and their relationship with soil temperature and moisture, an experiment was conducted in greenhouse melon fields by using the method of static chamber/gas chromatography to determine the CO and NO emissions of different nitrogen rates under aerated irrigation. There were two irrigation factors (AI: aerated irrigation; CK: conventional irrigation) and three N levels (N: 0; N: 150 kg·hm, the traditional nitrogen application rate was 2/3; N: 225 kg·hm, traditional nitrogen application rate). The results showed that soil CO and NO emissions in AI treatment were higher than those in CK, but no significant difference was observed between the two irrigation methods. Read More

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http://dx.doi.org/10.13287/j.1001-9332.201904.027DOI Listing

IgG4-related disease: Association with a rare gene variant expressed in cytotoxic T cells.

Mol Genet Genomic Med 2019 Apr 16:e686. Epub 2019 Apr 16.

Vanderbilt Center for Undiagnosed Disease, Vanderbilt University, Nashville, Tennessee.

Background: Family screening of a 48-year-old male with recently diagnosed IgG4-related disease (IgG4-RD) revealed unanticipated elevations in plasma IgG4 in his two healthy teenaged sons.

Methods: We performed gene sequencing, immune cell studies, HLA typing, and analyses of circulating cytotoxic CD4+ T lymphocytes and plasmablasts to seek clues to pathogenesis. DNA from a separate cohort of 99 patients with known IgG4-RD was also sequenced for the presence of genetic variants in a specific gene, FGFBP2. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.686
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http://dx.doi.org/10.1002/mgg3.686DOI Listing
April 2019
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