2 results match your criteria Agro Food Industry Hi-Tech[Journal]

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Omega-3 fatty acids: An update emphasizing clinical use.

Agro Food Ind Hi Tech 2012 Jul;23(4):10-13

Naturopathic Medicine Resident, Bastyr University.

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Iron: A Pathological Mediator of Alzheimer Disease?

Agro Food Ind Hi Tech 2009 Jan;19(6):33-36

Department of Pathology, Case Western Reserve University, Cleveland, Ohio USA.

Metal-catalyzed oxidation and free radical formation are potent mediators of cellular injury to every category of macromolecule found in vulnerable neuronal populations and are thought to play an early and central role in Alzheimer disease (AD) pathogenesis. While metal-binding sites are present in proteins that accumulate in AD, metal-associated redox activity is primarily noted with nucleic acids, specifically with cytoplasmic RNA. Iron dyshomeostasis in AD is thought to arise from haem breakdown and mitochondrial turnover, and a reduction in microtubule density in vulnerable neurons increases redox-active metals, initiating a cascade of events culminating in characteristic pathologic features. Read More

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January 2009
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