27,053 results match your criteria Agranulocytosis


Pure white cell aplasia an exceptional condition in the immunological conundrum of thymomas: Responses to immunosuppression and literature review.

Clin Case Rep 2022 May 9;10(5):e05742. Epub 2022 May 9.

Hematology Hospital Universitario Cruces Barakaldo Spain.

Thymomas are tumours frequently associated with autoimmune manifestations or immunodeficiencies like Good syndrome. In rare cases, pure white cells aplasia (PWCA) has been described in association with thymomas. PWCA is characterized by agranulocytosis of autoimmune background primary refractory to granulocyte colony-stimulating factor (G-CSF). Read More

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Possible involvement of apoptosis in the antipsychotics side effects: A minireview.

Clin Exp Pharmacol Physiol 2022 May 16. Epub 2022 May 16.

Biomedical Research Center, Slovak Academy of Sciences, Institute of Experimental Endocrinology, Dubravska cesta 9, Bratislava, Slovakia.

Antipsychotics are used in the treatment of schizophrenia and other psychiatric disorders. Generally they are divided into typical and atypical ones, according to the fact that atypical antipychotics induce less side effects and are more effective in terms of social and cognitive improvements. Their pharmacological effects are mediated via broad range of receptors that consequently influence different cellular signaling pathways. Read More

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Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to -Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite.

Chem Res Toxicol 2022 May 16. Epub 2022 May 16.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.

The atypical antipsychotic drugs, quetiapine and clozapine, are associated with idiosyncratic drug reactions (such as agranulocytosis or neutropenia) that are thought to involve reactive metabolites. Neutrophil myeloperoxidase (MPO) metabolism of quetiapine is not well-studied, but is metabolized by cytochrome P450. Based on structural similarity to clozapine, we hypothesized that quetiapine can be metabolized by MPO and that there is overlap between cytochrome P450 and MPO metabolism of quetiapine. Read More

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Association between cytokine concentration kinetics and prolonged fever in febrile neutropenic children with bacteremia.

Int J Immunopathol Pharmacol 2022 Jan-Dec;36:3946320221095015

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Introduction: Although prolonged fever in patients with neutropenic fever (NF) during empirical antibiotic therapy could be caused by dysregulated immune responses, its association with cytokine concentrations has rarely been investigated. This study determined the kinetics of cytokine concentrations in pediatric patients with NF and bacteremia and evaluated the impact of cytokine concentration kinetics on prolonged fever.

Methods: Concentrations of 13 cytokines were measured on the initial day of NF (Day 1) and 3 days (Day 4) and 7 days (Day 8) later in 10 patients with NF with bacteremia, and their kinetics was determined. Read More

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Carbimazole-Induced Agranulocytosis in a Previously Stable Patient: A Case Report and Literature Review.

Cureus 2022 Apr 13;14(4):e24115. Epub 2022 Apr 13.

Internal Medicine, Mid and South Essex NHS Foundation Trust, Southend-on-Sea, GBR.

Carbimazole-induced agranulocytosis is a rare condition. A 48-year-old female patient with a history of hyperthyroidism for several years presented with generalized fatigue and chest pain associated with palpitations; the patient was stable on carbimazole therapy. She was previously on carbimazole 15 mg once daily (OD) and, three months later, was reduced to 10 mg OD as symptoms were controlled. Read More

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In Silico Analysis Revealed Five Novel High-Risk Single-Nucleotide Polymorphisms (rs200384291, rs201163886, rs193141883, rs201139487, and rs201723157) in Gene Causing Autosomal Dominant Severe Congenital Neutropenia 1 and Cyclic Hematopoiesis.

ScientificWorldJournal 2022 6;2022:3356835. Epub 2022 May 6.

Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia.

Single-nucleotide polymorphisms in the (Elastase, Neutrophil Expressed) gene are associated with severe congenital neutropenia, while the gene provides instructions for making a protein called neutrophil elastase. We identified disease susceptibility single-nucleotide polymorphisms (SNPs) in the gene using several computational tools. We used cutting-edge computational techniques to investigate the effects of mutations on the sequence and structure of the protein. Read More

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Understanding the role of SGLT2 inhibitors in glycogen storage disease type Ib: the experience of one UK centre.

Orphanet J Rare Dis 2022 05 12;17(1):195. Epub 2022 May 12.

Inherited Metabolic Diseases, Evelina London Children's Hospital, London, SE1 7EH, UK.

Background: Glycogen storage disease type Ib (GSD Ib) is a severe disorder of carbohydrate metabolism due to bi-allelic variants in SLC37A4. It is associated with neutropaenia and neutrophil dysfunction, which has recently been attributed to the accumulation of 1,5-anhydroglucitol-6-phosphate (1,5AG6P) within neutrophils. Treatment with sodium-glucose co-transporter-2 (SGLT2) inhibitors, such as empagliflozin, is a novel therapy that reduces 1,5-anhydroglucitol (1,5AG) in plasma. Read More

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Clozapine and Neutropenia in Patients with Schizophrenia and SARS-CoV-2 Infection.

Neuropsychiatr Dis Treat 2022 4;18:977-983. Epub 2022 May 4.

Transilvania University of Brasov, Brasov, Romania.

Background: Clozapine (CLZ) is used for treatment-resistant schizophrenia (TRS). Adverse reactions to clozapine include neutropenia. In March 2020, WHO declared the COVID-19 pandemic and after, psychiatrists raised concerns regarding continuation of clozapine, due to multiple restrictions. Read More

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Clozapine Rechallenge or Continuation Despite Neutropenia, an Extended Follow-up of a Consecutive Quebec Case Series.

J Clin Psychopharmacol 2022 May 12. Epub 2022 May 12.

Département de psychiatrie et neurosciences, Faculté de médecine.

Background: Clozapine is the most efficacious antipsychotic for treatment-resistant schizophrenia. However, clozapine-induced neutropenia may warrant treatment discontinuation, hindering recovery. Several case reports describe clozapine rechallenge or continuation despite neutropenia, although many are subject to selective reporting, with incomplete information and short follow-up periods. Read More

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The Prevalence and Significance of Leukopenia Induced by Intravenous Iron Therapy in a Large Cohort of Females with Iron Deficiency Anemia (IDA).

Acta Biomed 2022 May 11;93(2):e2022183. Epub 2022 May 11.

Hematology Oncology Department, National Centre for Cancer Care and Research, Doha, (Qatar).

Introduction: Iron deficiency anemia (IDA) is the most common cause of anemia in both developed and developing countries. Leukopenia is an infrequent side effect of iron therapy reported in the literature as sporadic cases.

Objective: To assess the prevalence of leukopenia, neutropenia and/or lymphocytopenia and its possible clinical impact if any, after intravenous iron therapy in adult patients with IDA. Read More

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Heterogeneous genetic landscape of congenital neutropenia in Korean patients revealed by whole exome sequencing: genetic, phenotypic and histologic correlations.

Sci Rep 2022 May 7;12(1):7515. Epub 2022 May 7.

Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul, 110-744, Republic of Korea.

Congenital neutropenia (CN) is a hematological disease heterogeneous in its genetic, phenotypic and histologic aspects. We aimed to identify the genetic etiology of Korean CN patients in the context of bone marrow (BM) histology and clinical phenotype. Whole-exome sequencing (WES) or targeted sequencing was performed on the BM or peripheral blood specimens of 16 patients diagnosed with CN based on BM exam from 2009 to 2018. Read More

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A prediction model for bacteremia and transfer to intensive care in pediatric and adolescent cancer patients with febrile neutropenia.

Sci Rep 2022 May 6;12(1):7429. Epub 2022 May 6.

Department of Pediatrics, Division of Infectious Diseases, University of Chicago Medicine, Chicago, IL, USA.

Febrile neutropenia (FN) is a common condition in children receiving chemotherapy. Our goal in this study was to develop a model for predicting blood stream infection (BSI) and transfer to intensive care (TIC) at time of presentation in pediatric cancer patients with FN. We conducted an observational cohort analysis of pediatric and adolescent cancer patients younger than 24 years admitted for fever and chemotherapy-induced neutropenia over a 7-year period. Read More

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Drug Reaction with Eosinophilia and Systemic Symptoms and Agranulocytosis Presenting as Cervical Lymphadenopathy.

Hosp Pharm 2022 Feb 27;57(1):130-134. Epub 2021 Jan 27.

Monash Health, Clayton, VIC, Australia.

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare cause of cervical lymphadenopathy. It is a potentially life-threatening hypersensitivity reaction, commonly characterized by fever, rash, hematological abnormalities, and multi-organ involvement. Its association with agranulocytosis is even rarer, with fewer than 10 cases describing the coexistence of DRESS with agranulocytosis reported in the English literature. Read More

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February 2022

[Management of episodes of febrile neutropenia in children with cancer. Consensus of the Latin American Society of Pediatric Infectious Diseases 2021].

Rev Chilena Infectol 2021 12;38(6):857-909

Hospital Juan P. Garrahan, Buenos Aires, Argentina.

The Committee for Infections in Immunocompromised Children of Sociedad Latinoamericana de Infectología Pediátrica, presents this Consensus document, titled "Management of episodes of febrile neutropenia in children with cancer. Consensus of the Sociedad Latinoamericana de Infectología Pediátrica 2021". The document includes recommendations on prevention, prediction, diagnosis, treatment and prognosis of episodes of fever and neutropenia, including specific recommendations on: Analysis at admission; evaluation, adjustments and duration of antimicrobial therapies; diagnosis and management of invasive fungal infection; analysis of the main clinical source of infections; environmental conditions necessary for hospitals caring for children with cancer and chemoprophylaxis. Read More

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December 2021

[Microbiological characterization and antimicrobial susceptibility pattern of infections associated with febrile neutropenia in pediatric hemato-oncological patients.]

Andes Pediatr 2022 Feb 7;93(1):65-77. Epub 2022 Jan 7.

Universidad Industrial de Santander, Bucaramanga, Colombia.

Introduction: Febrile neutropenia (FN) is the most frequent hemato-oncological emergency, with high morbidi ty and mortality in pediatrics. The objective of the study was the microbiological characterization and antimicrobial susceptibility of infections associated with FN in pediatric hemato-oncological patients.

Patients And Method: Retrospective cohort study with patients aged between 1 month and 18 years, with onco-hematological pathology according to ICD-10 codes, hospitalized in a tertiary healthcare center in Bucaramanga, Colombia. Read More

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February 2022

Retrospective Cohort Study of Clinical Efficacy and Safety of Cefozopran for Treating Febrile Neutropenia during Chemotherapy in Patients with Lung Cancer.

Acta Med Okayama 2022 Apr;76(2):167-172

Department of Pharmacy, Okayama University Hospital.

Febrile neutropenia (FN) is a serious side effect in patients undergoing cancer chemotherapy and frequently proves fatal. Since infection control is crucial in the management of FN, the antimicrobial agent cefozopran (CZOP) has been recommended but not approved for routine use in clinical care of FN in Japan. However, few studies of CZOP in the management of FN have used a thrice daily dose schedule. Read More

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Phase 1 study of the liposomal formulation of eribulin (E7389-LF): Results from the breast cancer expansion cohort.

Eur J Cancer 2022 Jun 29;168:108-118. Epub 2022 Apr 29.

Department of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.

Background: A liposomal formulation of eribulin, E7389-LF, may provide improved pharmacokinetics and allow increased access to tumour tissues. This expansion of a phase 1 study assessed the safety and efficacy of E7389-LF in patients with human epidermal growth factor receptor type 2-negative metastatic breast cancer.

Methods: Patients received E7389-LF 2. Read More

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Case Report: A Novel Mutation in a Chinese Child With Kawasaki Disease Causing WHIM Syndrome.

Front Immunol 2022 13;13:857527. Epub 2022 Apr 13.

Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.

WHIM syndrome, an extremely rare congenital disease with combined immunodeficiency, is mainly caused by heterozygous gain-of-function mutation in the gene. There have been no previous case reports of WHIM syndrome with Kawasaki disease. We herein report a case of a boy who developed Kawasaki disease at the age of 1 year. Read More

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Usefulness of Prophylactic Administration of Pegfilgrastim for Esophageal Cancer Chemotherapy: A Single-center Retrospective Study.

Anticancer Res 2022 May;42(5):2783-2790

Department of Gastroenterological Surgery, Kanazawa University, Kanazawa, Japan.

Background/aim: To evaluate the impact of prophylactic administration of pegfilgrastim in esophageal cancer (EC) patients treated with chemotherapy consisted of docetaxel, cisplatin, and fluorouracil (DCF).

Patients And Methods: Among 102 patients who received neoadjuvant or induction DCF for primary advanced EC, 65 received prophylactic pegfilgrastim and 37 did not. The association of pegfilgrastim with adverse events and clinicopathological outcomes was retrospectively analyzed. Read More

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Comprehensive analysis of the associations between clinical factors and outcomes by machine learning, using post marketing surveillance data of cabazitaxel in patients with castration-resistant prostate cancer.

BMC Cancer 2022 Apr 29;22(1):470. Epub 2022 Apr 29.

Sanofi Global Oncology, 450 Water Street, Cambridge, MA, 02141, USA.

Background: We aimed to evaluate relationships between clinical outcomes and explanatory variables by network clustering analysis using data from a post marketing surveillance (PMS) study of castration-resistant prostate cancer (CRPC) patients.

Methods: The PMS was a prospective, multicenter, observational study of patients with metastatic, docetaxel-refractory CRPC treated with cabazitaxel in Japan after its launch in 2014. Graphical Markov (GM) model-based simulations and network clustering in 'R' package were conducted to identify correlations between clinical factors and outcomes. Read More

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Review of Hematological and Oncological Emergencies.

Adv Emerg Nurs J 2022 Apr-Jun 01;44(2):84-102

Ochsner Louisiana State University Health, Shreveport (Dr Barré); Atrium Health's Carolinas Medical Center, Charlotte, North Carolina (Dr McElwee); Medical University of South Carolina, Charleston (Drs Calhoun, Maldonado, and Bell); and Department of Clinical Pharmacy and Outcome Sciences, University of South Carolina College of Pharmacy, Columbia (Dr Weant).

Patients with hematological malignancies, both treated and untreated, or solid tumors undergoing treatment are at risk of life-threatening complications, which may present in the emergency department (ED). Such emergencies are diverse in etiology and often require prompt treatment. Traditional complications, such as febrile neutropenia, have had recent guideline updates, which incorporate new evidence and a new validated risk stratification tool. Read More

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[G-CSF for prophylaxis of neutropenia and febrile neutropenia, anemia in cancer : Guidelines on supportive treatment part 1].

Authors:
Hartmut Link

Urologe A 2022 May 27;61(5):537-551. Epub 2022 Apr 27.

, Finkenhain 8, 67661, Kaiserslautern, Deutschland.

Infections in patients with neutropenia following chemotherapy are mostly manifested as fever (febrile neutropenia, FN). Some of the most important determinants of the risk of FN are the type of chemotherapy, the dose intensity and patient-specific factors. When the risk of FN is 20% or more granulopoiesis is prophylactically stimulated with granulocyte colony stimulating factor (G-CSF) after the treatment. Read More

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Co-administration of morphine and levamisole increases death risk, produces neutropenia and modifies antinociception in mice.

Addict Biol 2022 05;27(3):e13166

Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav, IPN), Mexico City, Mexico.

Levamisole is a veterinary anthelmintic drug and a common adulterant of misused drugs. This study analyses the lethal, antinociceptive and haematological effects produced by acute or repeated levamisole administration by itself or combined with morphine. Independent groups of male Swiss Webster mice were i. Read More

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Design, synthesis and in vivo evaluation of 1,4-dioxo-2-butenyl aryl amine derivatives as a promising anti-inflammatory drug prototype.

Bioorg Chem 2022 Mar 26:105754. Epub 2022 Mar 26.

Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, ND 58078, United States. Electronic address:

Inflammation is a natural response of the organism to an infection, trauma, or cellular stress. Pain is the first symptom of acute and chronic inflammation. The standard class of medication to treat inflammatory pain is the nonsteroidal anti-inflammatory drug (NSAID). Read More

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Diagnostic Value of Bronchoalveolar Lavage Fluid Metagenomic Next-Generation Sequencing in Pneumonia in Non-HIV Immunosuppressed Patients.

Front Cell Infect Microbiol 2022 8;12:872813. Epub 2022 Apr 8.

Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Introduction: This study aims to assess the value of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) in the diagnosis of Pneumocystis jirovecii pneumonia (PJP) and its mixed infection in non-human immunodeficiency virus (HIV) immunosuppressed patients.

Methods: A total of 198 non-HIV immunosuppressed patients with severe pneumonia were enrolled, including 77 PJP patients and 121 patients infected by other pathogens. BALF-mNGS and traditional detection methods were used. Read More

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Ceftriaxone-Induced Reversible Agranulocytosis: A Case Report and Review of Drug-Induced Agranulocytosis.

Cureus 2022 Mar 16;14(3):e23226. Epub 2022 Mar 16.

Infectious Disease, University of Maryland (UM) Laurel Medical Center, Laurel, USA.

In the modern era of medicine, agranulocytosis is a rare occurrence. Despite significant improvement in patient survival, it still carries significant mortality. Agranulocytosis is most commonly caused by chemotherapeutic agents and numerous non-chemo drugs. Read More

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Hematologic Complications Associated With Intra-arterial Chemotherapy for Retinoblastoma Treatment: A Single Institution Experience.

J Pediatr Hematol Oncol 2022 05 25;44(4):181-185. Epub 2022 Mar 25.

Holtz Children's Hospital, Jackson Memorial Medical Center.

Retinoblastoma (RB) is the most common intraocular pediatric malignancy. Advancements in intra-arterial chemotherapy (IAC) for treatment of RB have resulted in dramatic improvement in eye salvage rates. Data regarding IAC outcomes and associated hematologic toxicities are limited. Read More

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Clinical Utility of Total Oxidative Stress and Total Antioxidant Capacity in Childhood Febrile Neutropenia.

J Pediatr Hematol Oncol 2022 05 13;44(4):142-146. Epub 2021 Aug 13.

Departments of Pediatric Hematology and Oncology.

The aim is to determine the oxidative status of children with febrile neutropenia (FEN). Blood samples were collected to determine the total antioxidant capacity (TAC) and total oxidative status (TOS) of healthy children (once) and children with FEN after 0, 48, and 96 hours. Eighteen patients with FEN were evaluated. Read More

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A study to evaluate the role of eosinophil count as a prognostic marker for assessing the outcome in patients with COVID 19 infection.

J Assoc Physicians India 2022 Apr;70(4):11-12

MS Ramaiah Medical College, Bengaluru.

The triaging of COVID 19 patients is of paramount importance to plan further management. There are several clinical and laboratory parameters that help in categorizing the disease severity, triaging, and prognostication. Little is known about the prognostic significance of eosinopenia in predicting the severity of COVID 19 from large hospital data especially from low- and middle-income countries. Read More

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