24,739 results match your criteria Agranulocytosis


Failure of rechallenge clozapine after agranulocytosis: A case report.

Encephale 2019 Mar 13. Epub 2019 Mar 13.

Department of psychiatry and addictology, Paul Brousse hospital, AP-HP, 12, avenue Paul Vaillant Couturier, 94800 Villejuif, France; Faculté de médecine, Paris Sud university, Le Kremlin-Bicetre, 94270 Île-de-France, France; Institut national de la santé et de la recherche médicale U 1178, 91190 Paris, France.

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http://dx.doi.org/10.1016/j.encep.2019.02.003DOI Listing

Oxacillin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

Am J Case Rep 2019 Mar 16;20:345-348. Epub 2019 Mar 16.

Department of Pulmonary and Critical Care, NYU Langone, New York City, NY, USA.

BACKGROUND Drug reaction with eosinophilia and systemic symptoms (DRESS) is an idiosyncratic life-threatening reaction comprised of fevers, rash, and leukocytosis with eosinophilia. Though characteristically associated with leukocytosis, there are rare case reports of DRESS-induced agranulocytosis. DRESS is most frequently caused by antiepileptic medications; however, it has very rarely been reported in relation to oxacillin. Read More

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http://dx.doi.org/10.12659/AJCR.913748DOI Listing

A meta-analysis of controlled studies comparing the association between clozapine and other antipsychotic medications and the development of neutropenia.

Aust N Z J Psychiatry 2019 Mar 13:4867419833166. Epub 2019 Mar 13.

2 School of Medicine, The University of Queensland, St Lucia, QLD, Australia.

Background:: In most countries, clozapine can only be prescribed with regular monitoring of white blood cell counts because of concerns that clozapine has a stronger association with neutropenia than other antipsychotics. However, this has not been previously demonstrated conclusively with meta-analysis of controlled studies.

Methods:: The aim of this study was to assess the strength of the association between clozapine and neutropenia when compared to other antipsychotic medications by a meta-analysis of controlled studies. Read More

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http://dx.doi.org/10.1177/0004867419833166DOI Listing
March 2019
1 Read

The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies.

Psychol Med 2019 Mar 12:1-12. Epub 2019 Mar 12.

Unit of Psychiatry,Centre of Translational Medicine, Faculty of Health Sciences, University of Macau,Macao SAR,China.

Background: Clozapine treatment increases the risk of agranulocytosis, but findings on the epidemiology of agranulocytosis have been inconsistent. This meta-analysis examined the prevalence of agranulocytosis and related death in clozapine-treated patients.

Methods: A literature search in the international (PubMed, PsycINFO, and EMBASE) and Chinese (WanFang, Chinese National Knowledge Infrastructure, and Sinomed) databases was conducted. Read More

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http://dx.doi.org/10.1017/S0033291719000369DOI Listing
March 2019
1 Read

Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand.

Asian J Psychiatr 2019 Mar 5;41:13-16. Epub 2019 Mar 5.

Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.03.002DOI Listing

[Leukemia caused by collision with a wild pig?]

Dtsch Med Wochenschr 2019 Mar 5;144(5):335-339. Epub 2019 Mar 5.

Medizinische Klinik 3, Centrum für Integrierte Onkologie (CIO) Köln-Bonn, Universitätsklinikum Bonn.

History:  A 23 years old, previously healthy woman was admitted to our clinic with neutropenic fever to rule out acute leukemia. Upon admission the patient reported that a few days ago the carcass of a pig had fallen on her from above, so that she experienced strong back pain.

Findings And Diagnosis:  The blood count showed thrombocytopenia and marked neutropenia of 0. Read More

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http://dx.doi.org/10.1055/a-0826-2446DOI Listing
March 2019
1 Read

Novel Association between Flavin-Containing Monooxygenase 3 Gene Polymorphism and Antithyroid Drug-Induced Agranulocytosis in the Han Population.

Ann Nutr Metab 2019 Feb 27;74(3):200-206. Epub 2019 Feb 27.

College of Medicine and Forensic, Health Science Center, Xi'an Jiao Tong University, Xi'an,

Some effective antithyroid drugs (ATDs) have been widely used for patients with Graves' disease (GD) but are associated with ATD-induced agranulocytosis. We selected 29 ATD-induced agranulocytosis patients, 44 ATD-induced neutropenia patients, and 140 GD controls among the Chinese Han population who were recruited at the First Affiliated Hospital of Xi'an Jiao Tong University. We assessed their response to ATDs treatment by performing genotyping for a candidate gene association study of samples from patients receiving treatment. Read More

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http://dx.doi.org/10.1159/000497314DOI Listing
February 2019
2 Reads

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

N Engl J Med 2019 02;380(8):741-751

From the Massachusetts General Hospital Cancer Center (A.B., S.J.I.) and Dana-Farber Cancer Institute (S.M.T.), Harvard Medical School, Boston; Vanderbilt-Ingram Cancer Center, Nashville (I.A.M., V.G.A.); Weill Cornell Medical College (L.T.V.) and New York-Presbyterian-Columbia University Irving Medical Center (K.K.), New York; University of Colorado Cancer Center, Aurora (J.R.D.); Texas Oncology, Baylor University Medical Center, US Oncology, Dallas (J.O.); Orlando Health University of Florida Health Cancer Center, Orlando (R.L.M., N.C.S.); Yale University School of Medicine, New Haven, CT (A.D.S.); University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (H.S.R.); Immunomedics, Morris Plains, NJ (D.M.G., R.I., S.W., R.M.S., W.A.W.); and AIS Consulting, Ann Arbor, MI (A.M.S.).

Background: Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1814213
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http://dx.doi.org/10.1056/NEJMoa1814213DOI Listing
February 2019
8 Reads

Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole: Correspondence.

Indian J Pediatr 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Pharmacology, TOBB Economics and Technology University Medical School, Söğütözü cad no, 43 06560, Ankara, Turkey.

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http://dx.doi.org/10.1007/s12098-019-02881-zDOI Listing
February 2019
1 Read

Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective.

Pharmacogenomics 2019 Feb 15. Epub 2019 Feb 15.

MRC Centre for Neuropsychiatric Genetics & Genomics, Division of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK.

Clozapine is the only effective antipsychotic for treatment-resistant schizophrenia but remains widely under prescribed, at least in part due to its potential to cause agranulocytosis and neutropenia. In this article, we provide an overview of the current understanding of the genetics of clozapine-associated agranulocytosis and neutropenia. We now know that the genetic etiology of clozapine-associated neutropenia is complex and is likely to involve variants from several genes including HLA-DQB1, HLA-B and SLCO1B3/SLCO1B7. Read More

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http://dx.doi.org/10.2217/pgs-2018-0188DOI Listing
February 2019
1 Read

Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer.

Anticancer Res 2019 Feb;39(2):1029-1034

Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan.

Aim: This study aimed to clarify the tolerability of a trifluridine/tipiracil combination tablet (TAS-102) in patients with advanced or recurrent colorectal cancer over 75 years of age.

Patients And Methods: Patients were divided into groups under the age of 75 years (n=62), and 75 years and over (n=17). The treatment period with TAS-102 tablet, reasons for discontinuation, adverse events (AEs), and overall survival (OS) were compared between the groups. Read More

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http://dx.doi.org/10.21873/anticanres.13209DOI Listing
February 2019
5 Reads

[Perioperative use of metamizole and other nonopioid analgesics in children : Results of a survey].

Anaesthesist 2019 Mar 24;68(3):152-160. Epub 2019 Jan 24.

Klinik für Anästhesiologie und Schmerztherapie, Universitätsklinik Bern, Inselspital, Universität Bern, Freiburgstrasse, 3010, Bern, Schweiz.

Background: Nonopioid analgesics are frequently used for perioperative pain management in children. In many countries, the nonopioid metamizole (dipyrone) is administered as an alternative to paracetamol and traditional NSAIDs (nonsteroidal anti-inflammatory drugs), such as ibuprofen and diclofenac; however, concerns over possible life-threatening adverse events (agranulocytosis) have prompted a debate over the use of metamizole.

Objective: To investigate current practice and use of nonopioid analgesics, particularly of metamizole in children younger than 14 years, in the perioperative setting. Read More

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http://dx.doi.org/10.1007/s00101-018-0532-4DOI Listing
March 2019
1 Read

[Mitoxantrone-cytarabine-etoposide induction therapy in children with acute myeloid leukemia: a single-center study of complications and clinical outcomes].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Jan;21(1):24-28

Department of Pediatric Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

Objective: To investigate the complications and clinical outcome of children with acute myeloid leukemia (AML) undergoing mitoxantrone-cytarabine-etoposide (MAE) induction therapy.

Methods: A total of 170 children with AML were given MAE induction therapy, and the complications and remission rate were analyzed after treatment.

Results: The male/female ratio was 1. Read More

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January 2019
6 Reads

Congenital neutropenia and primary immunodeficiency diseases.

Crit Rev Oncol Hematol 2019 Jan 13;133:149-162. Epub 2018 Oct 13.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

Neutropenia is a dangerous and potentially fatal condition that renders patients vulnerable to recurrent infections. Its severity is commensurate with the absolute count of neutrophil granulocytes in the circulation. In paediatric patients, neutropenia can have many different aetiologies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10408428173049
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http://dx.doi.org/10.1016/j.critrevonc.2018.10.003DOI Listing
January 2019
8 Reads
4.027 Impact Factor

Neutropenia at the time of subcutaneous port insertion may not be a risk factor for early infectious complications in pediatric oncology patients.

J Pediatr Surg 2019 Jan 5;54(1):145-149. Epub 2018 Oct 5.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center and Le Bonheur Children's Hospital, Memphis, TN. Electronic address:

Background: The risk of infection associated with subcutaneous port (SQP) placement in patients with neutropenia remains unclear. We reviewed the rate of early infectious complications (<30 days) following SQP placement in pediatric oncology patients with or without neutropenia [absolute neutrophil count (ANC) <500/mm].

Methods: Baseline characteristics and infectious complications were compared between groups using univariate and multivariate analyses. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347387PMC
January 2019
4 Reads

Monocytopenia in clozapine-induced agranulocytosis: insights into pathophysiology and treatment.

BMJ Case Rep 2019 Jan 18;12(1). Epub 2019 Jan 18.

Monter Cancer Center-Division of Hematology Oncology, Northwell Health, Lake Success, New York, USA.

A 26-year-old man with history of schizophrenia was admitted for neutropaenia. He was started on clozapine 3 months prior to admission. As a result he had weekly monitoring of his blood counts and on day of admission was noted to have an absolute neutrophil count (ANC) of 450 cells/μL. Read More

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http://dx.doi.org/10.1136/bcr-2018-226016DOI Listing
January 2019
6 Reads

Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells.

Biochem Pharmacol 2019 Jan 14;163:345-356. Epub 2019 Jan 14.

Division of Clinical Pharmacology & Toxicology, University Hospital, Basel, Switzerland; Department of Biomedicine, University of Basel, Switzerland; Swiss Centre of Applied Human Toxicology (SCAHT), Basel, Switzerland. Electronic address:

Metamizole is an analgesic and antipyretic, but can cause neutropenia and agranulocytosis. We investigated the toxicity of the metabolites N-methyl-4-aminoantipyrine (MAA), 4-aminoantipyrine (AA), N-formyl-4-aminoantipyrine (FAA) and N-acetyl-4-aminoantipyrine (AAA) on neutrophil granulocytes and on HL60 cells (granulocyte precursor cell line). MAA, FAA, AA, and AAA (up to 100 µM) alone were not toxic for HL60 cells or granulocytes. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.01.011DOI Listing
January 2019
2 Reads

Increased Risk of Antithyroid Drug Agranulocytosis Associated with Amiodarone-Induced Thyrotoxicosis: A Population-Based Cohort Study.

Thyroid 2019 Feb;29(2):193-201

3 Department of Community Medicine and Epidemiology, Clalit Health Services, Haifa, Israel.

Background: Agranulocytosis occurs in 0.2-0.5% of patients treated with the antithyroid drugs (ATDs) methimazole and propylthiouracil. Read More

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http://dx.doi.org/10.1089/thy.2018.0274DOI Listing
February 2019
2 Reads

Acute agranulocytosis when switching from risperidone to paliperidone.

Aust N Z J Psychiatry 2019 Jan 14:4867418821441. Epub 2019 Jan 14.

Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.1177/0004867418821441DOI Listing
January 2019
6 Reads

Mutation, drift and selection in single-driver hematologic malignancy: Example of secondary myelodysplastic syndrome following treatment of inherited neutropenia.

PLoS Comput Biol 2019 01 7;15(1):e1006664. Epub 2019 Jan 7.

Systems Engineering Group, Silesian University of Technology, Gliwice, Poland.

Cancer development is driven by series of events involving mutations, which may become fixed in a tumor via genetic drift and selection. This process usually includes a limited number of driver (advantageous) mutations and a greater number of passenger (neutral or mildly deleterious) mutations. We focus on a real-world leukemia model evolving on the background of a germline mutation. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336352PMC
January 2019
3 Reads

Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies.

AAPS PharmSciTech 2019 Jan 2;20(1):22. Epub 2019 Jan 2.

Department of Pharmaceutics, Sinhgad Institute of Pharmacy, Sinhgad Technical Education Society, Narhe, Pune, MS, 411041, India.

Potential risk of agranulocytosis is one of the drug-induced adverse effects of the second-generation antipsychotic agents. The present investigation aimed to formulate and investigate olanzapine (OLZ)-loaded nanostructured lipid carriers (OLZ-NLCs) via intranasal (i.n. Read More

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http://dx.doi.org/10.1208/s12249-018-1213-yDOI Listing
January 2019
5 Reads

5-HT deletion protects against Clozapine-induced hyperglycemia.

J Pharmacol Sci 2019 Feb 18;139(2):133-135. Epub 2018 Dec 18.

National Centre for Biological Sciences, TIFR, GKVK Campus, Bellary Road, Bengaluru, India; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA. Electronic address:

Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT (Serotonin receptor subtype-2A). Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.015DOI Listing
February 2019
2 Reads

A qualitative exploration of clozapine prescribing and monitoring practices in the Arabian Gulf countries.

Asian J Psychiatr 2019 Jan 21;39:93-97. Epub 2018 Dec 21.

Hamad Medical Corporation, Mental Health Hospital, Doha, Qatar.

Clozapine is considered as the first line antipsychotic for treatment resistant schizophrenia (TRS). Worldwide reports indicate an overall underutilization of clozapine in patients experiencing TRS. This study aims to understand the prescribing practices, monitoring strategies and barriers to the use of clozapine in the Arabian Gulf (AG) region. Read More

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http://dx.doi.org/10.1016/j.ajp.2018.12.011DOI Listing
January 2019
1 Read

Severe acute pancreatitis with blood infection by Candida glabrata complicated severe agranulocytosis: a case report.

BMC Infect Dis 2018 Dec 29;18(1):706. Epub 2018 Dec 29.

Department of Emergency Internal Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, Shanghai, 201203, People's Republic of China.

Background: Blood infection with Candida glabrata often occurs in during severe acute pancreatitis (SAP). It complicate severe agranulocytosis has not been reported.

Case Presentation: We present a case where a SAP patient presenting with a sudden hyperpyrexia was treated for 19 days. Read More

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http://dx.doi.org/10.1186/s12879-018-3623-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310945PMC
December 2018
5 Reads
2.613 Impact Factor

Intravenously administered cloxacillin-induced neutropenia with eosinophilia in a patient with infective endocarditis: a case report.

J Med Case Rep 2018 Dec 29;12(1):384. Epub 2018 Dec 29.

Teaching Hospital Kurunegala, Kurunegala, Sri Lanka.

Background: Bacteremia following Staphylococcus aureus is a serious clinical condition which is often associated with distant metastatic infections. One of the most dreaded complications of Staphylococcus aureus bacteremia is infective endocarditis. Cloxacillin is a common antibiotic prescribed for suspected staphylococcal infections and confirmed methicillin-sensitive Staphylococcus aureus infections. Read More

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http://dx.doi.org/10.1186/s13256-018-1933-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310943PMC
December 2018
2 Reads

Levamisole-induced vasculitis.

JAAPA 2019 Jan;32(1):23-27

At the John S. Dunn Burn Center at Memorial Hermann Hospital, part of the University of Texas Health Science Center at Houston, Tex., Tonya C. George is an assistant professor of surgery, Daniel J. Freet is an assistant professor, James M. Cross is a professor of surgery, and Todd F. Huzar is an associate professor of surgery. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Levamisole is a veterinary antihelminthic, chemotherapeutic agent, and immunomodulator that also is used as an adulterant and cutting agent in cocaine distribution. This drug may potentiate the sympathomimetic actions of cocaine and can cause neutropenia, agranulocytosis, purpuric retiform lesions, and skin necrosis. This article describes two cases of suspected levamisole-induced vasculitis. Read More

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http://dx.doi.org/10.1097/01.JAA.0000547746.08181.f7DOI Listing
January 2019
1 Read

Azathioprine-induced Agranulocytosis and Severe Alopecia After Kidney Transplantation Associated With a NUDT15 Polymorphism: A Case Report.

Transplant Proc 2018 Dec 18;50(10):3925-3927. Epub 2018 Apr 18.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan. Electronic address:

Background: Azathioprine (AZA) is the drug recommended for the continuation of immunosuppressive treatment after renal transplant in women during pregnancy.

Case Report: A 37-year-old Japanese female developed agranulocytosis and severe alopecia after initiation of AZA (50 mg), used as an alternative to mycophenolate mofetil (MMF, 1000 mg) therapy in anticipation of a planned pregnancy. Within 4 days of the initiation of AZA therapy, the patient developed a high fever, leucopenia, and cranial alopecia. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.039DOI Listing
December 2018
1 Read

Fatal Invasive Pulmonary Aspergillosis Associated with Nonspecific Interstitial Pneumonia: An Autopsy Case Report.

Intern Med 2018 15;57(24):3619-3624. Epub 2018 Dec 15.

Department of Respiratory Medicine, Toho University Omori Medical Center, Japan.

Invasive pulmonary aspergillosis (IPA) usually occurs in patients with severe immunodeficiencies involving neutropenia. Underlying lung disease is a well-known risk factor of IPA; however, interstitial lung disease has not been recognized as a risk factor of IPA. We herein report a patient with fibrotic nonspecific interstitial pneumonia who experienced IPA without neutropenia. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/57/24/
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http://dx.doi.org/10.2169/internalmedicine.1144-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355419PMC
January 2019
13 Reads

Mask Off? Lithium Augmentation for Clozapine Rechallenge After Neutropenia or Agranulocytosis: Discontinuation Might Be Risky.

Prim Care Companion CNS Disord 2018 Nov 29;20(6). Epub 2018 Nov 29.

PSTAR Clinic, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.4088/PCC.18l02282DOI Listing
November 2018

Diagnostic workup in front of an adult neutropenia.

Ann Biol Clin (Paris) 2018 Dec;76(6):651-658

Service de médecine interne, Centre hospitalier de Royan, Vaux-sur-mer, France, Groupement de coopération sanitaire de Saintonge, Laboratoire inter-hospitalier de biologie médicale, Centres hospitaliers de Saint-Jean-d'Angély, Saintes, Royan et Jonzac, Saint-Jean-d'Angély.

Adult neutropenia, defined as a blood neutrophil count below 1.5 G/L, is a common condition. The most common cause of acute neutropenia is a drug-related reaction or an acute infectious disease. Read More

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http://dx.doi.org/10.1684/abc.2018.1393DOI Listing
December 2018

Complete remission of pure white cell aplasia associated with thymoma after thymectomy and cyclosporine administration.

Int J Hematol 2019 Mar 9;109(3):346-350. Epub 2018 Dec 9.

Department of Haematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

We present the case of a 63-year-old male with pure white cell aplasia (PWCA), a rare complication of thymoma, who was successfully treated with cyclosporine A (CyA) and thymectomy. The patient presented with high fever and agranulocytosis. Complete blood count revealed a white blood cell count of 0. Read More

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http://dx.doi.org/10.1007/s12185-018-02573-yDOI Listing
March 2019
3 Reads

[Agranulocytosis during therapy of chronic myeloid leukemia lymphoid blast crisis with dasatinib].

Rinsho Ketsueki 2018;59(11):2438-2440

Department of Hematology, Japan Community Health Care Organization, Kyoto Kuramaguchi Medical Center.

A 61-year-old female was diagnosed with a lymphoid crisis of chronic myeloid leukemia (CML) in February 201X and started chemotherapy combined with dasatinib (DAS). After 1 month of initiating second consolidation therapy, the neutrophils decreased to 1%, bone marrow examination revealed large granular lymphocytes (LGL) at 13%, and complete cytogenetic remission was attained (CCyR). Suspecting DAS-induced agranulocytosis, DAS was discontinued. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/11/59_2438/
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http://dx.doi.org/10.11406/rinketsu.59.2438DOI Listing
January 2018
11 Reads

The Disturbed Function of Neutrophils at the Early Stage of Fat Grafting Impairs Long-Term Fat Graft Retention.

Plast Reconstr Surg 2018 11;142(5):1229-1238

Guangzhou, Guangdong, People's Republic of China From the Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University.

Background: Fat grafting is a popular soft-tissue filler method; however, the mechanism of its survival and regeneration is still not fully understood. Neutrophils are the frontier inflammatory cells and closely associated with tissue regeneration. To understand the role of neutrophils in fat graft retention, we adopted neutrophil depletion and up-regulation models. Read More

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http://dx.doi.org/10.1097/PRS.0000000000004882DOI Listing
November 2018
2 Reads

A novel experimental intraperitoneal infection model for Haemophilus parasuis in neutropenic guinea pigs.

J Pharmacol Toxicol Methods 2019 Jan - Feb;95:27-35. Epub 2018 Nov 23.

National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Introduction: Haemophilus parasuis, one of the major swine pathogens, has at least fifteen different types, all of which have significant economic effects on the global swine industry. The aim of this study was to establish an experimental intraperitoneal infection model for H. parasuis in neutropenic guinea pigs. Read More

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http://dx.doi.org/10.1016/j.vascn.2018.11.008DOI Listing
March 2019
10 Reads

The role of temperature in the detection and diagnosis of neutropenic sepsis in adult solid tumour cancer patients receiving chemotherapy.

Eur J Oncol Nurs 2018 Dec 21;37:12-18. Epub 2018 Oct 21.

University of Sheffield, Weston Park Hospital, Witham Road, Sheffield, S10 2SJ, UK.

Purpose: The primary aim of this study was to examine the value of temperature as a diagnostic and prognostic indicator of infection and sepsis in neutropenic patients. A secondary aim was to gain insight into the presenting symptoms reported by these patients at home or on their initial admission assessment.

Methods: A cohort study was carried out using a case note review of 220 emergency admissions to a regional cancer centre. Read More

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http://dx.doi.org/10.1016/j.ejon.2018.10.001DOI Listing
December 2018
7 Reads

Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report.

Clin Psychopharmacol Neurosci 2018 Nov;16(4):501-504

Departments of Child Hematology and Oncology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

Autoimmune hemolytic anemia is a disease characterized with destruction of erythrocytes as a result of antibody produce against patient's own erythrocytes and anemia. Autoimmune hemolytic anemia can be roughly stratified into two groups according to serological features and secondary causes including drugs induced hemolytic anemia. Drugs induced autoimmune hemolytic anemia is very rare in pediatric patients. Read More

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http://dx.doi.org/10.9758/cpn.2018.16.4.501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245293PMC
November 2018
2 Reads

Effects of Clozapine on the Gut: Cross-Sectional Study of Delayed Gastric Emptying and Small and Large Intestinal Dysmotility.

CNS Drugs 2019 Jan;33(1):81-91

Department of Psychological Medicine, University of Otago, PO Box 7343, Wellington, 6242, New Zealand.

Background: Gastrointestinal hypomotility in people taking clozapine is common, poorly understood and potentially dangerous. It causes distress and sometimes sudden death, with greater associated morbidity than the better known adverse effect of clozapine, agranulocytosis. Neither the mechanism nor prevalence of clozapine-induced gastrointestinal hypomotility is well understood. Read More

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http://dx.doi.org/10.1007/s40263-018-0587-4DOI Listing
January 2019
16 Reads

[The Case of a Patient with Gastric Cancer Who Showed No Neutropenia Only When Using the Generic S-1 Adjuvant Chemotherapy Formulation].

Gan To Kagaku Ryoho 2018 Nov;45(11):1653-1655

Dept. of Gastroenterological Surgery, Aichi Cancer Center Hospital.

We report the case of a 72-year-old female who underwent laparoscopic total gastrectomy for gastric cancer. The pathological diagnosis was pT3, N1, M0, pStage II B. She received adjuvant chemotherapy with the TS-1®combination OD tablet, beginning 48 days after gastrectomy. Read More

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November 2018
15 Reads

VCAM-1-mediated neutrophil infiltration exacerbates ambient fine particle-induced lung injury.

Toxicol Lett 2019 Mar 15;302:60-74. Epub 2018 Nov 15.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 Dongan Road, Building 7, Room 214, Shanghai, 200032, PR China. Electronic address:

Background: Fine ambient particle matter (PM2.5) induces inflammatory lung injury; however, whether intratracheal administration of PM2.5 increases pulmonary polymorphonuclear leukocyte (PMN) infiltration, the mechanism of infiltration, and if these cells exacerbate PM2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784274183204
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http://dx.doi.org/10.1016/j.toxlet.2018.11.002DOI Listing
March 2019
29 Reads

Biosimilar filgrastim treatment patterns and prevention of febrile neutropenia: a prospective multicentre study in France in patients with solid tumours (the ZOHé study).

BMC Cancer 2018 Nov 16;18(1):1127. Epub 2018 Nov 16.

Institut de Cancerologie Hartmann, Levallois-Perret, France.

Background: The ZOHé study was a prospective, non-interventional, multicentre study in France to assess the use of biosimilar filgrastim Zarzio® (Sandoz filgrastim) in routine clinical practice in patients at risk of neutropenia-inducing chemotherapy (CT).

Methods: Patients ≥ 18 years undergoing CT for a malignant disease and with a first prescription for Zarzio® were enrolled in two cohorts according to tumour type: solid tumour or haematological malignancy; results from the solid tumour cohort are reported here. Analyses primarily described the prescription and use of Zarzio® in current practice, and also included identification of factors linked to prescription for primary prophylaxis and comparison of Zarzio® use in relation to European Organisation for Research and Treatment of Cancer (EORTC) guidelines. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4986-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240200PMC
November 2018
16 Reads

Risk of febrile neutropenia among patients with multiple myeloma or lymphoma who undergo inpatient versus outpatient autologous stem cell transplantation: a systematic review and meta-analysis.

BMC Cancer 2018 Nov 16;18(1):1126. Epub 2018 Nov 16.

Division of Hematology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, 10400, Thailand.

Background: Outpatient autologous stem cell transplantations (ASCTs) in multiple myeloma and lymphoma patients have been shown to reduce the overall costs and improve the quality of life relative to inpatient ASCTs. This systematic review and meta-analysis was performed with the aim of comprehensively comparing the risk of febrile neutropenia developing in ASCT outpatients and inpatients who have multiple myeloma or lymphoma.

Methods: To be eligible for the meta-analysis, studies needed to be either randomized, controlled studies or cohort studies. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-5054-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240267PMC
November 2018
17 Reads
3.362 Impact Factor

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.

N Engl J Med 2018 11;379(19):1811-1822

From the National and Kapodistrian University of Athens, Athens (M.A.D.); Karol Marcinkowski University of Medical Sciences, Poznań (D.D.), and Silesian Medical University, Katowice (S.G.) - both in Poland; University Hospital, Nantes (P.M.), and Centre Hospitalier Universitaire de Poitiers-La Milétrie, Poitiers (X.L.) - both in France; National Hospital Organization Disaster Medical Center (N.T.) and the Japanese Red Cross Medical Center (K.S.), Tokyo, and Ibaraki Prefectural Central Hospital, Kasama (M.H.) - all in Japan; Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal (R.L.); Heidelberg University Hospital, Heidelberg, Germany (M.S.R.); Dana-Farber Cancer Institute, Boston (P.G.R.); Bristol-Myers Squibb, Princeton, NJ (M.P.M., Y.-M.J., S.G.S., M.R., B.R.); and Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra (IDISNA), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Pamplona, Spain (J.S.-M.).

Background: The immunostimulatory monoclonal antibody elotuzumab plus lenalidomide and dexamethasone has been shown to be effective in patients with relapsed or refractory multiple myeloma. The immunomodulatory agent pomalidomide plus dexamethasone has been shown to be effective in patients with multiple myeloma that is refractory to lenalidomide and a proteasome inhibitor.

Methods: Patients with multiple myeloma that was refractory or relapsed and refractory to lenalidomide and a proteasome inhibitor were randomly assigned to receive elotuzumab plus pomalidomide and dexamethasone (elotuzumab group) or pomalidomide and dexamethasone alone (control group). Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1805762
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http://dx.doi.org/10.1056/NEJMoa1805762DOI Listing
November 2018
20 Reads

[Therapeutic Effect and Adverse Events of Ramucirumab in Patients with Gastric Cancer in Our Hospital].

Gan To Kagaku Ryoho 2018 Oct;45(10):1549-1551

Dept. of Surgery, Gifu Municipal Hospital.

From January 2016 through December 2017, 18 patients received paclitaxel plus ramucirumab combination therapy and 1 patient received ramucirumab monotherapy. Thus, a total of 19 patients were analyzed in terms of both therapeutic effect and adverse events. The response evaluation of the targeted lesion was as follows; CR: 0, PR: 1, SD: 16, PD: 2. Read More

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October 2018
2 Reads

[Examination of Fever Risk Factors after Prophylaxis with G-CSF].

Gan To Kagaku Ryoho 2018 Oct;45(10):1431-1434

Dept. of Pharmacy, Jichi Medical University Hospital.

Febrile neutropenia is a serious adverse drugreaction to cancer chemotherapy. Prophylactic administration of granulocyte colony-stimulatingfactor (G-CSF)is recommended in patients who require cancer chemotherapy associated with a risk of febrile neutropenia or intense treatment. However, we had patients who developed fever after prophylactic administration of G-CSF. Read More

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October 2018
2 Reads

Pitfalls of immunotherapy: lessons from a patient with CTLA-4 haploinsufficiency.

Allergy Asthma Clin Immunol 2018 22;14:65. Epub 2018 Oct 22.

1Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC Australia.

Background: Daclizumab is a humanized monoclonal antibody that blocks CD25, the high affinity alpha subunit of the interleukin-2 receptor. Daclizumab therapy targets T regulatory cell and activated effector T cell proliferation to suppress autoimmune disease activity, in inflammatory conditions like relapsing and remitting multiple sclerosis. Here, we present the first report of agranulocytosis with daclizumab therapy in a patient with relapsing and remitting multiple sclerosis. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
Publisher Site
http://dx.doi.org/10.1186/s13223-018-0272-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196561PMC
October 2018
22 Reads

A case of Alemtuzumab-induced neutropenia in multiple sclerosis in association with the expansion of large granular lymphocytes.

BMC Neurol 2018 Oct 29;18(1):178. Epub 2018 Oct 29.

1st Department of Neurology, Medical School of Athens, National & Kapodistrian University, Aeginition Hospital, Athens, Greece.

Background: Alemtuzumab has been demonstrated to reduce the risks of relapse and accumulation of sustained disability in Multiple Sclerosis (MS) patients compared to β-interferon. It acts against CD52, leading primarily to lymphopenia. Recent data have shown that mild neutropenia is observed in 16% of treated MS-patients whereas severe neutropenia occurred in 0. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
Publisher Site
http://dx.doi.org/10.1186/s12883-018-1183-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206708PMC
October 2018
9 Reads

An atypical occurrence of Aspergillosis in leukemic patient: Brief description of a clinical case.

J Mycol Med 2018 Dec 23;28(4):655-658. Epub 2018 Oct 23.

Laboratory of Microbiology, A.O. SS Antonio e Biagio e Cesare Arrigo, Via Venezia 16, 15121 Alessandria, Italy. Electronic address:

Herein we describe a 43 year-old Caucasian female patient with acute myeloid leukemia that developed an unconventional form of invasive Aspergillosis. For therapeutic reasons, a Groshong-type central venous catheter was positioned. Monitoring the patient's clinical conditions, positive values for C-reactive protein and galactomannan were correlated with a probably Aspergillosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11565233183010
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http://dx.doi.org/10.1016/j.mycmed.2018.10.002DOI Listing
December 2018
14 Reads

Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis.

Oxf Med Case Reports 2018 Nov 22;2018(11):omy094. Epub 2018 Oct 22.

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, Japan.

An 82-year-old man with a recurrence of pulmonary pleomorphic carcinoma was treated with pembrolizumab. He achieved partial response after three cycles of pembrolizumab. However, he developed febrile neutropenia. Read More

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https://academic.oup.com/omcr/article/doi/10.1093/omcr/omy09
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http://dx.doi.org/10.1093/omcr/omy094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196766PMC
November 2018
13 Reads

Appraising of the Clinical Practice Guidelines Quality in the Non-Pharmacological Management of Chemotherapy-Induced Febrile Neutropenia; A Review

Asian Pac J Cancer Prev 2018 Oct 26;19(10):2701-2707. Epub 2018 Oct 26.

Social Determinant Health Research Center, Faculty of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad, Iran. Email: Taleghani@ nm.mui.ac.ir

Background: Febrile neutropenia is a common and serious chemotherapy side effect, is associated with increased mortality, morbidity, and treatment expenditures. Several CPGs (Clinical practice guidelines) have been released for managing chemotherapy-induced febrile neutropenia. The aim of this study is Appraisal of the clinical practice Guidelines quality in the management of chemotherapy-induced febrile neutropenia. Read More

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http://journal.waocp.org/article_69905.html
Publisher Site
http://dx.doi.org/10.22034/APJCP.2018.19.10.2701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291058PMC
October 2018
10 Reads

Invasive Fungal Disease in Children with Acute Leukemia: The Elusive Culprit.

Indian J Pediatr 2018 12 16;85(12):1059-1060. Epub 2018 Oct 16.

Pediatric Hematology-Oncology Unit, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://link.springer.com/10.1007/s12098-018-2802-1
Publisher Site
http://dx.doi.org/10.1007/s12098-018-2802-1DOI Listing
December 2018
7 Reads
0.920 Impact Factor