24,267 results match your criteria Agranulocytosis


Clozapine-related Paroxysmal Supraventricular Tachycardia: a Case Report.

Authors:
S J Kim M S Gim

East Asian Arch Psychiatry 2018 Jun;28(2):68-70

Department of Psychiatry, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Korea.

Clozapine is considered to be more effective than other antipsychotic drugs for treating treatmentresistant schizophrenia. However, side effects of clozapine include agranulocytosis and, less commonly, cardiovascular disease, which is occasionally fatal. We describe a 56-year-old woman who developed clozapine-related paroxysmal supraventricular tachycardia during clozapine dose titration and had a recurrence despite being treated with verapamil. Read More

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Topical application of 5-fluorouracil 5 percent cream associated with severe neutropenia: discussion of a case and review of systemic reactions after topical treatment with 5-fluorouracil.

Authors:
Philip R Cohen

Dermatol Online J 2018 Apr 15;24(4). Epub 2018 Apr 15.

Department of Dermatology, University of California San Diego, La Jolla, California.

5-fluorouracil, a fluoropyrimidine antineoplastic drug, is used to topically treat actinic keratoses. Local skin reactions to the medication are common and anticipated. However, severe adverse events from topical 5-fluorouracil are rare and unexpected. Read More

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April 2018
4 Reads

Recurrent Levamisole-Induced Agranulocytosis Complicated by Bowel Ischemia in a Cocaine User.

Am J Case Rep 2018 Jun 1;19:630-633. Epub 2018 Jun 1.

Department of Pulmonary, Critical Care and Sleep Medicine, University of Toledo Medical Center, Toledo, OH, USA.

BACKGROUND Levamisole is a common adulterant of cocaine and up to 69% of seized cocaine in United States contains levamisole. It is a synthetic imidazothiazole derivative which was previously used as an immunomodulating agent for treatment of various connective tissue disorders and colorectal carcinoma. However, it was withdrawn later from the market due to significant toxicity associated with it. Read More

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Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future.

Int J Endocrinol 2018 22;2018:5794054. Epub 2018 Apr 22.

Division of Endocrine and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Hyperthyroidism is a common endocrine disease. Although thionamide antithyroid drugs are the cornerstone of hyperthyroidism treatment, some patients cannot tolerate this drug class because of its serious side effects including agranulocytosis, hepatotoxicity, and vasculitis. Therefore, nonthionamide antithyroid drugs (NTADs) still have an important role in controlling hyperthyroidism in clinical practice. Read More

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Phase II Trial of Carboplatin and Pemetrexed Plus Bevacizumab with Maintenance Bevacizumab as a First-line Treatment for Advanced Non-squamous Non-small Cell Lung Cancer in Elderly Patients.

Anticancer Res 2018 Jun;38(6):3779-3784

Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.

Background/aim: The combination of platinum-doublet chemotherapy with bevacizumab has been established as a first-line treatment option in non-elderly patients with non-squamous (non-sq) non-small cell lung cancer (NSCLC). However, the safety and efficacy of this regimen have not yet been fully established in elderly patients.

Patients And Methods: Chemo-naïve patients with non-sq NSCLC, aged ≥75 years, having a good performance status (Eastern Cooperative Oncology Group performance status 0-1) and adequate organ function were considered eligible. Read More

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June 2018
2 Reads

Definitive Chemoradiation in Locally Advanced Squamous Cell Carcinoma of the Hypopharynx: Long-term Outcomes and Toxicity.

Anticancer Res 2018 Jun;38(6):3543-3549

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, U.S.A.

Background/aim: Definitive chemoradiation (CRT) is a common approach for locally advanced hypopharyngeal squamous cell carcinoma (SCC) with the goal of organ preservation. Reports on long-term oncologic and functional outcomes have been limited. This study reports on outcomes utilizing this approach at a single institution over 30 years. Read More

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Side Effects and Interactions of the Xanthine Oxidase Inhibitor Febuxostat.

Pharmaceuticals (Basel) 2018 May 25;11(2). Epub 2018 May 25.

Internal Medicine, Medical Faculty, Ludwig Maximilians University of Munich, 80539 Munich, Germany.

The paper addresses the safety of febuxostat and summarizes reports on side effects and interactions of febuxostat published by the cut-off date (last day of literature search) of 20 March 2018. Publications on side effects and the interactions of febuxostat were considered. Information concerning the occurrence of side effects and interactions in association with the treatment with febuxostat was collected and summarized in the review. Read More

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May 2018
1 Read

Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of clozapine.

Ther Adv Drug Saf 2018 May 6;9(5):237-256. Epub 2018 Feb 6.

Department of Neuroscience, Imaging and Clinical Science, Chair of Psychiatry, University 'G. D'Annunzio', Chieti, Italy.

Clozapine, a dibenzodiazepine developed in 1961, is a multireceptorial atypical antipsychotic approved for the treatment of resistant schizophrenia. Since its introduction, it has remained the drug of choice in treatment-resistant schizophrenia, despite a wide range of adverse effects, as it is a very effective drug in everyday clinical practice. However, clozapine is not considered as a top-of-the-line treatment because it may often be difficult for some patients to tolerate as some adverse effects can be particularly bothersome (i. Read More

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May 2018
2 Reads

Meta-analysis examining the epidemiology of clozapine-associated neutropenia.

Acta Psychiatr Scand 2018 May 21. Epub 2018 May 21.

School of Medicine, University of Queensland, St Lucia, Qld, Australia.

Background: Clozapine is associated with life-threatening neutropenia. There are no previous meta-analyses of the epidemiology of clozapine-associated neutropenia.

Objectives: To determine the cumulative incidence of mild, moderate and severe neutropenia, incidence of death related to severe neutropenia, case fatality rate of neutropenia and the longitudinal incidence of neutropenia following exposure to clozapine. Read More

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[Case Report - Metamizole-Induced Agranulocytosis].

Anasthesiol Intensivmed Notfallmed Schmerzther 2018 May 17;53(5):388-394. Epub 2018 May 17.

Metamizole is primarily used for severe perioperative pain, acute injury and colic, and cancer pain. For other acute/chronic forms of pain and high fever, it should only be used if unresponsive to other agents. Metamizole should not be used for middle and low pain. Read More

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Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia.

Cochrane Database Syst Rev 2018 05 8;5:CD012349. Epub 2018 May 8.

5639 Gowland Rd., Sechelt, BC, Canada, V0N 3A8.

Background: Regularly transfused people with sickle cell disease (SCD) and people with thalassaemia (who are transfusion-dependent or non-transfusion-dependent) are at risk of iron overload. Iron overload can lead to iron toxicity in vulnerable organs such as the heart, liver and endocrine glands; which can be prevented and treated with iron chelating agents. The intensive demands and uncomfortable side effects of therapy can have a negative impact on daily activities and well-being, which may affect adherence. Read More

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Efficacy and safety of iron chelators in thalassemia and sickle cell disease: a multiple treatment comparison network meta-analysis and trial sequential analysis.

Expert Rev Clin Pharmacol 2018 May 18:1-10. Epub 2018 May 18.

b School of Oral Health, College of Medicine, Nursing and Health Sciences , Fiji National University , Suva , Fiji islands.

Background: To compare the efficacy and safety of desferrioxamine (DFO), deferiprone (DFP), deferasirox (DFX) and silymarin in patients with either thalassemia or sickle cell disorder through network meta-analysis.

Methods: Electronic databases were searched for appropriate randomized clinical trials comparing iron chelators in patients with iron overload. Random effects model was used to generate direct, indirect and mixed treatment comparison pooled estimates for the following outcomes: serum ferritin, liver iron concentration (LIC), changes in serum ferritin, mortality, urine iron excretion, adverse events, neutropenia, agranulocytosis and number of patients withdrawing the chelating therapy. Read More

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May 2018
4 Reads

A pharmacokinetics and pharmacodynamics equivalence trial of the proposed pegfilgrastim biosimilar, MYL-1401H, versus reference pegfilgrastim.

J Cancer Res Clin Oncol 2018 Jun 18;144(6):1087-1095. Epub 2018 Apr 18.

Global Clinical Research and Development, Mylan Inc, Canonsburg, PA, USA.

Purpose: Pegfilgrastim is a long-acting granulocyte colony-stimulating factor indicated for prevention of febrile neutropenia in patients receiving myelosuppressive chemotherapy by promoting neutrophil recovery.

Methods: This phase 1, randomized, double-blind, three-way crossover trial in healthy volunteers evaluated the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of the proposed biosimilar, comparing MYL-1401H, reference pegfilgrastim (Neulasta, Amgen Inc, Thousand Oaks, CA, USA) sourced from the European Union, and reference pegfilgrastim sourced from the USA. Primary PK end points were peak plasma concentration of pegfilgrastim (C) and area under the plasma concentration-time curve from the time of dosing to infinity (AUC). Read More

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June 2018
9 Reads

Transient immune-mediated agranulocytosis following infection.

BMJ Case Rep 2018 Apr 18;2018. Epub 2018 Apr 18.

Haematology Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

is a common respiratory pathogen which may cause haematological manifestations including haemolytic anaemia and thrombocytopaenia. Severe neutropaenia is rare with very few cases reported in the literature. An 85-year-old man was transferred to our facility with agranulocytosis in the context of an infective exacerbation of chronic obstructive pulmonary disease with positive serological testing for No alternative infective, autoimmune or lymphoproliferative cause of the neutropaenia was identified. Read More

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April 2018
2 Reads

[Febrile neutropenia in cancer patients: management in the emergency room].

Rev Chilena Infectol 2018;35(1):62-71

Servicio de Infectología, Hospital Nacional de Niños Carlos Sáenz Herrera, San José, Costa Rica.

Febrile neutropenia is a life-threatening condition that requires immediate attention, especially in patients with chemotherapy-related neutropenia. Patients with febrile neutropenia have a much greater risk of developing bacterial disease, and fever may be the only indicator of severe bacterial infection. Adequate management of febrile neutropenia emphasizes early recognition of patients, risk stratification, and antibiotic therapy administration during the first 60 minutes of admission to an emergency room. Read More

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[Neoadjuvant chemotherapy with concurrent chemoradiotherapy in the treatment of nasopharyngeal cancer: Southern Tunisian experience].

Bull Cancer 2018 May 9;105(5):450-457. Epub 2018 Apr 9.

CHU Habib Bourguiba, service de radiothérapie carcinologique, Bourguiba route El Ain km 1,5, 3000 Sfax, Tunisie.

Purpose: A retrospective study to evaluate the efficacy and safety of the addition of neoadjuvant chemotherapy to concurrent chemoradiotherapy in the treatment of nasopharyngeal carcinoma.

Patients And Methods: Data from 62 patients treated for non-metastatic nasopharyngeal carcinoma were analyzed by comparing two groups of patients: a first group of 32 patients treated with 3 cycles of neoadjuvant chemotherapy based on docetaxel, cisplatin and 5-fluoro-uracil every 21 days followed by concurrent chemoradiotherapy (weekly cisplatin 40mg/m with radiotherapy 70Gy, 2Gy per session, 5 sessions per week) and a second group of 30 patients treated with the same concurrent chemoradiotherapy.

Results: After a median follow-up of 53. Read More

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Minimization of the perianal infection rate of hematological malignancies with agranulocytosis by quality control circle activity and patient-hospital-student win-win concept.

J Int Med Res 2018 Jun 10;46(6):2338-2345. Epub 2018 Apr 10.

1 Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China.

Objective The agranulocytosis-associated perianal infection (PI) rate ranges from 60% to 100% among patients with hematopoietic malignancies. In this study, we assessed the efficacy of a quality control circle (QCC) to minimize the PI rate. Methods Among 274 patients with severe immunodeficiency (agranulocytosis of ≥2 weeks) in our bone marrow transplantation center, the PI rate was 17. Read More

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June 2018
2 Reads

Galactomannan Antigen Test for Early Diagnosis of Invasive Aspergillus Infection in Pediatric Febrile Neutropenia.

Indian Pediatr 2018 03;55(3):257-258

Department of Pediatrics, AIIMS, New Delhi, India.

Invasive aspergillosis is a major concern in neutropenic patients. We studied the utility of Galactomannan antigen detection test in serum using ELISA technique for early detection of invasive aspergillosis. Diagnostic accuracy of Galactomannan index (GMI) test was maximum at a cut-off of > 1. Read More

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March 2018
1 Read
1.01 Impact Factor

A Case of Levamisole-Induced Agranulocytosis.

Case Rep Hematol 2018 11;2018:7341835. Epub 2018 Feb 11.

Department of Internal Medicine, Creighton University, Omaha, NE, USA.

A sixty-eight-year-old male with a past medical history of recurrent cocaine use presented to the emergency department with recurrent diarrhea and was found to have a white blood cell (WBC) count of 1.9 × 10/L with agranulocytosis (absolute neutrophil count (ANC) of 95 cell/mm). At admission, the patient disclosed that he used cocaine earlier during the day, and a urine drug screen tested positive for this. Read More

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February 2018
2 Reads

Enterocolitis in Patients with Cancer Treated with Docetaxel.

Anticancer Res 2018 04;38(4):2443-2446

Department of Medical Oncology, University Hospital of Besançon, Besançon, France.

Background: Enterocolitis is a rare, but serious gastrointestinal complication associated with docetaxel-based chemotherapy in patients with cancer. The incidence, clinical presentation and outcome of enterocolitis in patients with cancer treated with docetaxel-based chemotherapy was assessed in this study Patients and Methods: All patients treated with docetaxel for cancer between January 2010 and December 2014 at the University Hospital of Besançon were identified and their medical records reviewed.

Results: During this period, 1,227 patients received docetaxel chemotherapy and gastrointestinal events occurred in 381 (31. Read More

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April 2018
7 Reads

Costs associated with febrile neutropenia in Japanese patients with primary breast cancer: post-hoc analysis of a randomized clinical trial.

Jpn J Clin Oncol 2018 May;48(5):410-416

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto.

Background: Febrile neutropenia (FN), a decrease in blood neutrophils accompanied by fever, is a major adverse event (AE) associated with cancer chemotherapy. We aimed to estimate the direct medical costs associated with FN management in breast cancer patients within a clinical trial with pegfilgrastim, a pegylated form of recombinant granulocyte colony-stimulating factor (G-CSF).

Methods: We obtained data from 346 Japanese breast cancer patients in a randomized, placebo-controlled clinical trial comparing FN incidence due to TC adjuvant chemotherapy (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2) between pegfilgrastim-treated and placebo groups. Read More

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May 2018
3 Reads

Clozapine-related neutropenia, myocarditis and cardiomyopathy adverse event reports in Australia 1993-2014.

Psychopharmacology (Berl) 2018 Mar 27. Epub 2018 Mar 27.

Metro South Addiction and Mental Health Service, 228 Logan Road, Woolloongabba, QLD, 4102, Australia.

Rationale: Clozapine is the gold-standard medicine for treating refractory schizophrenia but there are some notable serious adverse events (AE). We aimed to analyse reported rates of clozapine cardiac and haematological AEs in Australia.

Methods: Using data from the Therapeutic Goods Administration, we examined all reported clozapine AEs (1993-2014) with a specific focus on neutropenia, myocarditis and cardiomyopathy. Read More

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March 2018
3 Reads

Venetoclax-Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia.

N Engl J Med 2018 Mar;378(12):1107-1120

From the Peter MacCallum Cancer Centre, Royal Melbourne Hospital, and University of Melbourne, Melbourne, VIC (J.F.S.), and the John Curtin School of Medical Research, Australian National University, Canberra, ACT (J.D.) - all in Australia; the University of California School of Medicine, San Diego (T.J.K.), and Genentech, South San Francisco (E.A.P., Y.L., M. Mobasher) - both in California; University Hospital Cologne and the Center for Integrated Oncology Cologne-Bonn, Cologne, Germany (B.E.); St. James's University Hospital, Leeds (P.H.), and F. Hoffmann-La Roche, Welwyn Garden City (M.B., K.H.) - both in the United Kingdom; Segal Cancer Center, Lady Davis Institute, Jewish General Hospital, Montreal (S.A.), and the Departments of Medicine and Oncology, University of Calgary, Calgary, AB (C.O.) - all in Canada; Memorial Sloan Kettering Cancer Center, New York (J.G.); the Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz, Poland (T.R.); Hospital Universitario 12 de Octubre, Madrid (J.D.S.); Medical University of Vienna, Department of Medicine I, Division of Hematology and Hemostaseology, Vienna (U.J.); the Department of Hematology, Centre Hospitalier Universitaire Montpellier, Montpellier, France (G.C.); the Department of Onco-Hematology, Division of Hematology, Niguarda Cancer Center, Niguarda Hospital, Milan (M. Montillo); AbbVie, North Chicago, IL (R.H.); and the Department of Hematology, Cancer Center Amsterdam, Academic Medical Center, Amsterdam (A.P.K.).

Background: Venetoclax inhibits BCL2, an antiapoptotic protein that is pathologically overexpressed and that is central to the survival of chronic lymphocytic leukemia cells. We evaluated the efficacy of venetoclax in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia.

Methods: In this randomized, open-label, phase 3 trial, we randomly assigned 389 patients to receive venetoclax for up to 2 years (from day 1 of cycle 1) plus rituximab for the first 6 months (venetoclax-rituximab group) or bendamustine plus rituximab for 6 months (bendamustine-rituximab group). Read More

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March 2018
3 Reads

Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor.

Case Rep Med 2018 23;2018:8439791. Epub 2018 Jan 23.

Department of Internal Medicine, Hiroshima Kyoritsu Hospital, Hiroshima, Japan.

When elderly patients are prescribed many different medications, the risk for developing serious adverse events should be kept in mind. One of these adverse events is agranulocytosis, which, although rare, can be life-threatening if left untreated. The majority of agranulocytosis cases are caused by drugs, including antibiotics. Read More

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January 2018
3 Reads

Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature.

Case Rep Endocrinol 2018 10;2018:4135940. Epub 2018 Jan 10.

Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Aim: To present a case of Graves' disease complicated by methimazole induced agranulocytosis treated with therapeutic plasma exchange (TPE) and review of the literature.

Case Presentation: A 21-year-old patient with a history of Graves' disease presented to the endocrine clinic. His history was significant for heat intolerance, weight loss, and tremors. Read More

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January 2018
6 Reads

Clozapine-induced cardiomyopathy and myocarditis monitoring: A systematic review.

Schizophr Res 2018 Mar 13. Epub 2018 Mar 13.

Pharmacy Services, Mayo Clinic, Rochester, MN, United States. Electronic address:

The use of clozapine requires monitoring the absolute neutrophil count because of the risk of agranulocytosis, but other potentially fatal adverse events associated with clozapine (specifically, myocarditis and cardiomyopathy) do not have mandatory procedures. We performed a systematic review of English-language articles to synthesize an evidence-based approach for myocarditis and cardiomyopathy monitoring. Articles published from January 1988 through February 2017 were identified through a search of Ovid MEDLINE, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Web of Science, Scopus, and Google Scholar. Read More

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March 2018
2 Reads

Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases.

Case Rep Hematol 2018 10;2018:5846398. Epub 2018 Jan 10.

Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

A 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates. Read More

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January 2018
2 Reads

New findings in pharmacogenetics of schizophrenia.

Curr Opin Psychiatry 2018 May;31(3):200-212

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health.

Purpose Of Review: This review highlights recent advances in the investigation of genetic factors for antipsychotic response and side effects.

Recent Findings: Antipsychotics prescribed to treat psychotic symptoms are variable in efficacy and propensity for causing side effects. The major side effects include tardive dyskinesia, antipsychotic-induced weight gain (AIWG), and clozapine-induced agranulocytosis (CIA). Read More

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May 2018
4 Reads

[Proposal of informed consent by representation for treatment with clozapine].

Vertex 2017 Sep;XXVIII(135):330-337

Capítulo de Discapacidad Intelectual y del Desarrollo de APSA.

Clozapine-induced agranulocytosis, a potentially serious adverse effect, is a limiting factor for its therapeutic use, leading to the suspension of the drug. Its annual incidence in Argentina is 0.05%. Read More

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September 2017

DRESS syndrome: a detailed insight.

Hosp Pract (1995) 2018 Mar 15:1-11. Epub 2018 Mar 15.

a Department of Clinical Pharmacology , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry , India.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious and potentially fatal adverse effect to therapeutic medications. The incidence of this condition varies among different ethnicities because of the difference in the genetic makeup. Though fever, rash and eosinophilia are essential features for the diagnosis of this syndrome, these vary from patient to patient along with the involvement of various organs such as liver, kidney, lungs, pancreas, etc. Read More

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March 2018
3 Reads

[Clinical study of low cytomegalovirus viral load thresholds for preemptive antiviral therapy in hematopoietic cell transplant recipients].

Zhonghua Nei Ke Za Zhi 2018 Mar;57(3):191-195

Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China.

To investigate the threshold of cytomegalovirus (CMV) DNAemia for preemptive antiviral therapy in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Viral load between 1×10(3) copies/ml and 5×10(3) copies/ml was defined as low viral load by real time Q-PCR. Clinical data and outcome were collected. Read More

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ELANE gene mutation-induced cyclic neutropenia manifesting as recurrent fever with oral mucosal ulcer: A case report.

Medicine (Baltimore) 2018 Mar;97(10):e0031

Department of Pediatrics, First Hospital Affiliated to Bengbu Medical College, Bengbu Anhui, China.

Background: Cyclic neutropenia (CyN) is a rare hematological disease. Herein, a CyN girl, aged 3 years and 2 months, with recurrent fever and oral mucosal ulcer caused by neutrophil elastase (ELANE) gene mutation is reported.

Case Presentation: A 3 years and 2 months old girl presented with recurrent fever and oral mucosal ulcer for 1 year. Read More

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March 2018
10 Reads

Sudden death in schizophrenia.

Curr Opin Psychiatry 2018 May;31(3):169-175

VA Boston Healthcare System.

Purpose Of Review: To examine the recent literature regarding sudden death in patients with schizophrenia and synthesize salient conclusions based on this evidence.

Recent Findings: Sudden cardiac death (SCD) is the largest subset of sudden unexpected death (SUD), with up to 40% of SUD from cardiovascular causes. SCD has been associated with exposure to both first and second-generation antipsychotics. Read More

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May 2018
1 Read

Clozapine Rechallenge After Major Adverse Effects: Clinical Guidelines Based on 259 Cases.

Am J Ther 2018 Mar/Apr;25(2):e218-e223

Mental Health Centre Glostrup, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Clozapine is widely prescribed for treatment-refractory schizophrenia, but its use is limited by many potentially life-threatening adverse effects. The risk of rechallenge after these complications has never been comprehensively assessed in controlled studies. Thus, clinical guidelines must rely on the published case reports. Read More

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March 2018
3 Reads

[Role of Pharmacists in Completion of Adjuvant Cisplatin-Vinorelbine Chemotherapy in Japanese Patients with Non-small Cell Lung Cancer].

Yakugaku Zasshi 2018 ;138(3):437-442

Department of General Thoracic Surgery, Kyorin University School of Medicine.

 Adjuvant cisplatin-vinorelbine chemotherapy has been shown to be effective in patients with completely resected non-small cell lung cancer (NSCLC) in several Phase III trials, but not yet in the Japanese population. Pharmacists are expected to assist patients with completion of adjuvant chemotherapy. The aim of this retrospective study was to evaluate the compliance with and safety of adjuvant cisplatin-vinorelbine chemotherapy in Japanese patients and to evaluate the contribution of pharmacists to completion of treatment. Read More

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March 2018
1 Read

Potentially fatal outcomes associated with clozapine.

Schizophr Res 2018 Mar 1. Epub 2018 Mar 1.

VA Boston Healthcare System, 940 Belmont St., Bld 2, Brockton, MA 02301, USA; Harvard South Shore Psychiatry Residency Training Program, 940 Belmont St., Bld 5 116-A7, Brockton, MA, 02301, USA; Harvard Medical School, 25 Shattuck St., Boston, MA 02115, USA.

Clozapine has been shown to be the most efficacious therapy for treatment resistant schizophrenia, estimated at one third of all schizophrenia cases. There is significant morbidity and mortality associated with clozapine including risk of agranulocytosis, aspiration pneumonia, bowel ischemia, myocarditis, seizures, and weight gain. Here we present a case of a 62-year-old man with chronic paranoid schizophrenia refractory to numerous antipsychotics who was started on clozapine therapy during an acute inpatient psychiatric admission. Read More

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March 2018
4 Reads

Clozapine Patients at the Interface between Primary and Secondary Care.

Pharmacy (Basel) 2018 Feb 26;6(1). Epub 2018 Feb 26.

School of Pharmacy, University College Cork, Cork T12 YN60, Ireland.

Patients receiving clozapine must undergo routine blood monitoring to screen for neutropenia, and to monitor for potential agranulocytosis. In Cork University Hospital, Cork, Ireland, clozapine is dispensed in the hospital pharmacy and the pharmacists are not aware of co-prescribed medicines, potentially impacting upon patient safety. The aim of this study was to examine the continuity of care of patients prescribed clozapine. Read More

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February 2018
2 Reads

A Feasibility Study of Capecitabine and Oxaliplatin for Patients with Stage II/III Colon Cancer -ACTOR Study.

Anticancer Res 2018 03;38(3):1741-1747

Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

Background/aim: Past studies have suggested that adjuvant capecitabine and oxaliplatin (CAPOX) provides decreased tumor relapse and longer survival in patients with curatively resected colon cancer. We report the first evidence of the feasibility of adjuvant CAPOX in Japanese patients with early colon cancer.

Patients And Methods: Eligible patients had histologically-confirmed stage II/III colon cancer and received curative resection. Read More

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March 2018
6 Reads

The safety and clinical efficacy of recombinant human granulocyte colony stimulating factor injection for colon cancer patients undergoing chemotherapy.

Authors:
Jie Chen Yin Pan

Rev Assoc Med Bras (1992) 2017 Dec;63(12):1061-1064

Clinic Medical College, Jilin University, Jilin, China.

Objective: The present study was designed to evaluate safety and efficacy of recombinant human granulocyte colony stimulating factor (G-CSF) injection and whether this regimen could reduce the incidence of adverse events caused by chemotherapy.

Method: A total of 100 patients with colon cancer who were treated with chemotherapy in our hospital from January 2011 to December 2014 were randomly divided into two groups, with 50 patients in each group. The patients in the treatment group received G-CSF 24 hours after chemotherapy for consecutive three days; the patients in the control group received the same dose of normal saline. Read More

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December 2017

The influence of different fever definitions on diagnostics and treatment after diagnosis of fever in chemotherapy-induced neutropenia in children with cancer.

PLoS One 2018 20;13(2):e0193227. Epub 2018 Feb 20.

Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Background: There is no evidence-based definition of the temperature limit defining fever (TLDF) in children with neutropenia. Lowering the TLDF is known to increase the number of episodes of fever in neutropenia (FN). This study aimed to investigate the influence of a lower versus standard TLDF on diagnostics and therapy. Read More

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May 2018
2 Reads

A Phase II Study of Irinotecan for Patients with Previously Treated Small-Cell Lung Cancer.

Oncology 2018 14;94(4):223-232. Epub 2018 Feb 14.

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Objective: Chemotherapy with irinotecan plus cisplatin has shown promise in chemo-naïve small-cell lung cancer (SCLC) patients. However, irinotecan treatment for relapsed or refractory SCLC has not been adequately evaluated. This phase II study evaluated the appropriate treatment schedule of irinotecan as a single agent. Read More

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March 2018
3 Reads

Reply to Ziesenitz, Victoria; Erb Thomas; Trachsel, Daniel; van den Anker Johannes, regarding their comment "Safety of dipryone (metamizole) in children-what's the risk of agranulocytosis?"

Paediatr Anaesth 2018 Mar;28(3):305-306

Department of Pediatric Intensive Care and Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.

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March 2018
8 Reads

Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study.

J Basic Clin Physiol Pharmacol 2018 Feb 13. Epub 2018 Feb 13.

Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Laboratório de Farmacologia Clínica e Experimental (LaFaCE), Departamento de Farmacologia, Rua José Lourenço Kelmer, s/n. 36036-900, Juiz de Fora, MG, Brasil, Phone: +55 32 2102-3369; 55 32 2102-3210, Fax: +55 32 2102-3216.

Background: Dipyrone is a non-narcotic analgesic/antipyretic widely used in some countries but prohibited in others due to suspected risk of agranulocytosis. The primary goal of this study was to evaluate hematological alterations in healthy adult volunteers after treatment with dipyrone.

Methods: The study enrolled 30 healthy volunteers of both genders, aged 19-37 years. Read More

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February 2018
2 Reads

Continuously infused amphotericin B deoxycholate for primary treatment of invasive fungal disease in acute myeloid leukaemia.

Hematol Oncol 2018 Apr 12;36(2):471-480. Epub 2018 Feb 12.

Division of Hematology, University Hospital Zurich, Switzerland.

Continuous administration of amphotericin B deoxycholate over 24 hours (24 h-D-AmB) is better tolerated than rapid infusions. However, toxicity and outcome have not been assessed in a homogenous patient population with acute myeloid leukaemia (AML). We retrospectively analysed renal function and outcome in all adult patients with AML undergoing intensive chemotherapy between 2007 and 2012 at our institution. Read More

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April 2018
9 Reads

Unique Effects of Clozapine: A Pharmacological Perspective.

Adv Pharmacol 2018 12;82:137-162. Epub 2018 Jan 12.

Geisel School of Medicine at Dartmouth, Hanover, NH, United States; Dartmouth Clinical and Translational Science Institute, Dartmouth College, Hanover, NH, United States. Electronic address:

Schizophrenia is a heterogenous and severe neuropsychiatric disorder that affects nearly 1% of the population worldwide. Antipsychotic drugs are the mainstay of treatment, but not all patients with schizophrenia respond to treatment with these agents. Clozapine, the first atypical antipsychotic, is a highly effective medication for patients with schizophrenia who do not respond to other antipsychotics. Read More

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January 2018
2 Reads

[Role of neutrophil dysfunction in the pathogenesis of systemic lupus erythematosus].

Ter Arkh 2017;89(12):110-113

M.V. Lomonosov Moscow State University, Moscow, Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Neutrophil dysfunction plays a considerable role.in systemic lupus erythematosus (SLE) The protective function of neutrophils is carried out through various mechanisms: isolation of granular antimicrobial peptides (gAMP), microbial phagocytosis with subsequent degradation via reactive oxygen species inside the phagolysosomes; as well as bactericidal action due to the release of networks from chromatin and gAMP, also called neutrophil extracellular traps (NECTs). The development of neutropenia in SLE has multiple causes, including the formation of antibodies directly to leukocytes; that of neutralizing autoantibodies to the growth factors of neutrophils and cells - myeloid precursors; bone marrow suppression; involvement of neutrophils in the processes of apoptosis and NETosis. Read More

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May 2018
1 Read

Febrile events in acute lymphoblastic leukemia: a prospective observational multicentric SEIFEM study (SEIFEM-2012/B ALL).

Ann Hematol 2018 May 7;97(5):791-798. Epub 2018 Feb 7.

Istituto di Ematologia, Università Cattolica del Sacro Cuore, Largo F. Vito, 1, 00168, Rome, Italy.

The purpose of the present study is to estimate the current incidence of febrile events (FEs) and infectious episodes in acute lymphoblastic leukemia (ALL) and evaluate the outcome. We analyzed data on all FEs in a cohort of patients affected by ALL admitted to 20 Italian hematologic centers during 21 months of observation from April 1, 2012 to December 31, 2013. Data about treatment phase, steroids, neutropenia, type and site of infection, and outcome of infection were collected. Read More

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May 2018
2 Reads

Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature.

J Thromb Thrombolysis 2018 May;45(4):588-592

Coronary Care Unit, "O.Barberi", "G.F.Ingrassia" Hospital, Palermo, Italy.

This case report describes agranulocytosis immediately after oral administration of dabigatran in a 68 years old man with atrial fibrillation (AF). Dabigatran is an oral, reversible and competitive thrombin inhibitor that has shown promising results. In patients with atrial fibrillation of RE-LY study (Randomized Evaluation of Long-Term Anticoagulant Therapy), dabigatran administered at a dose of 150 mg, as compared with warfarin, was associated with lower rates of stroke and systemic embolism but similar rates of major hemorrhage. Read More

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May 2018
6 Reads

[Usefulness of eosinopenia for the diagnosis of sepsis in emergency department: Still debated].

Rev Med Interne 2018 03 2;39(3):208-209. Epub 2018 Feb 2.

Service de maladies infectieuses, hôpital Raymond Poincaré, hôpitaux universitaires Paris Île-de-France Ouest, 92380 Garches, France.

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