25,553 results match your criteria Agranulocytosis


Severe clozapine-induced agranulocytosis: successful treatment with G-CSF and rechallenge of clozapine plus D2 potentiation therapy (amisulpride).

Actas Esp Psiquiatr 2020 Mar 1;48(2):89-98. Epub 2020 Mar 1.

Servicio de Hematología, Hospital de la Merced, Osuna (Sevilla). España.

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Nøytropeni ved behandling med antipsykotika.

Tidsskr Nor Laegeforen 2020 May 25;140(8). Epub 2020 May 25.

Neutropenia and agranulocytosis are among the most serious and feared adverse effects of antipsychotic drugs. In affected patients there is a risk of both infection and exacerbation of the underlying psychotic disorder, because neutropenia and agranulocytosis often require discontinuation of the antipsychotic drug therapy. The cause is most likely multifactorial. Read More

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http://dx.doi.org/10.4045/tidsskr.19.0713DOI Listing

A Patient with Fulminant Myasthenia Gravis is Seropositive for Both AChR and LRP4 Antibodies, Complicated by Autoimmune Polyglandular Syndrome Type 3.

Intern Med 2020 May 26. Epub 2020 May 26.

Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Japan.

This article describes the first reported case of myasthenia gravis (MG) seropositive for both acetylcholine receptor antibody and low-density lipoprotein receptor-related protein 4 antibody, complicated by autoimmune polyglandular syndrome (APS) type 3. The patient exhibited myasthenic weakness restricted to the ocular muscles and ptosis. Severe clinical deterioration ensued with predominant bulbar symptoms. Read More

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http://dx.doi.org/10.2169/internalmedicine.4708-20DOI Listing

Barriers and opportunities for the clinical implementation of therapeutic drug monitoring in oncology.

Br J Clin Pharmacol 2020 May 19. Epub 2020 May 19.

UniSA Clinical & Health Sciences, University of South Australia, Adelaide, SA, Australia.

There are few fields of medicine in which the individualisation of medicines is more important than in the area of oncology. Under-dosing can have significant ramifications due to the potential for therapeutic failure and cancer progression; on the other hand, over-dosing may lead to severe treatment-limiting side effects, such as agranulocytosis and neutropenia. Both circumstances lead to poor patient prognosis and contribute to the high mortality rates still seen in oncology. Read More

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http://dx.doi.org/10.1111/bcp.14372DOI Listing

Clozapine-induced agranulocytosis in Japan: Changes in leukocyte/neutrophil counts before and after discontinuation of clozapine.

Hum Psychopharmacol 2020 May 18. Epub 2020 May 18.

Department of Psychiatry, Tokyo Women's Medical University, Tokyo, Japan.

Objective: To determine the prevalence, background factors, and progression of and recovery from clozapine-induced agranulocytosis in Japan.

Methods: Data on treatment-resistant schizophrenia patients registered with the Clozaril Patient Monitoring Service (CPMS) between July 29, 2009 and January 20, 2016 were extracted. Patients with a neutrophil count <500/mm were defined as having agranulocytosis, and those with a leukocyte count <3,000/mm or a neutrophil count <1,500/mm but not meeting the criteria for agranulocytosis were defined as having leukopenia/neutropenia. Read More

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http://dx.doi.org/10.1002/hup.2739DOI Listing

Clozapine and hematologic adverse reactions: Impact of the Risk Evaluation and Mitigation Strategy program.

Ment Health Clin 2020 May 7;10(3):70-75. Epub 2020 May 7.

Introduction: In October 2015, the Food and Drug Administration (FDA) instituted an update to the mandatory Risk Evaluation and Mitigation Strategy (REMS) program for clozapine to improve safety monitoring of hematologic events. However, the impact of the clozapine REMS program on reporting of hematologic adverse events has not been quantified.

Methods: We assessed adverse event reports for agranulocytosis, granulocytopenia, leukopenia, and neutropenia from the FDA Adverse Event Reporting System (FAERS) for a 1-year time period before (October 2014 to September 2015, pre-REMS) and after (October 2015 to September 2016, post-REMS) the implementation of the clozapine REMS program. Read More

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http://dx.doi.org/10.9740/mhc.2020.05.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213944PMC

Pharmacogenetics of Antipsychotic Drug Treatment: Update and Clinical Implications.

Mol Neuropsychiatry 2020 Apr 26;5(Suppl 1):1-26. Epub 2018 Sep 26.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Numerous genetic variants have been shown to be associated with antipsychotic response and adverse effects of schizophrenia treatment. However, the clinical application of these findings is limited. The aim of this narrative review is to summarize the most recent publications and recommendations related to the genetics of antipsychotic treatment and shed light on the clinical utility of pharmacogenetics/pharmacogenomics (PGx). Read More

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http://dx.doi.org/10.1159/000492332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206586PMC

METHIMAZOLE-INDUCED AGRANULOCYTOSIS AND SEPSIS: WAS THYROID STORM PRESENT OR JUST BEING MIMICKED?

Acta Endocrinol (Buchar) 2019 Oct-Dec;15(4):522-525

Ponta Grossa State University - Medicine, Ponta Grossa, Brazil.

Introduction: Agranulocytosis induced by thioamides is rare, occurring only in 0.2-0.5% of cases. Read More

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http://dx.doi.org/10.4183/aeb.2019.522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200104PMC

Reporting Patterns of Sialorrhea Comparing Users of Clozapine to Users of Other Antipsychotics: A Disproportionality Analysis Using VigiBase.

J Clin Psychopharmacol 2020 May/Jun;40(3):283-286

From the Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht.

Background: Sialorrhea is a non-life-threatening, but potentially invalidating adverse drug reaction (ADR) in patients using clozapine. In light of the very serious ADRs (agranulocytosis and myocarditis), sialorrhea is at risk to be overlooked by health care professionals. In this study, the sialorrhea reporting patterns of clozapine compared with other antipsychotics were assessed by evaluating differences in relative reporting frequency and reporter type. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188267PMC

[Clinical Features of Nosocomial Infections in Agranulocytosis Patients with Hematological Malignancies and Analysis of Risk Factors].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):669-676

Department of Hematology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China,E-mail: xiyaming@ 163.com.

Objective: To explore the clinical features and risk factors for nosocomial infections in agranulocytosis patients with hematological malignancies so as to provide basis for clinical prevention and treatment of nosocomial infections.

Methods: The clinical data of 725 patients with agranulocytosis in the First Hospital of Lanzhou University from May 2015 to May 2018 were retrospectively analyzed, including sex, age, primary disease, treatment stage, agranulocytosis degree, agranulocytosis duration, nosocomial infection, infectous site, average length of stay and average days of infection. Univariate analysis (Chi-square test) and multivariate analysis (non-conditional Logistic regression models) were used to analyze the risk factors of nosocomial infection. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.052DOI Listing

Trastuzumab with FLOT Regimen for the Perioperative Treatment of Resectable HER2 + Advanced Gastric Cancer: A Retrospective Study.

Cancer Manag Res 2020 8;12:2481-2489. Epub 2020 Apr 8.

Department of Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, People's Republic of China.

Background: The aim of this study was to evaluate the efficacy and safety of trastuzumab, combined with the FLOT regimen, in the perioperative treatment of resectable HER-2-positive advanced gastric cancer.

Methods: Overall, 45 patients were divided into two groups; 29 patients in the experimental group were treated with trastuzumab combined with FLOT and 16 patients in the control group were treated with FLOT alone. The primary endpoint was objective response rate (ORR), and the secondary endpoints were disease control rate (DCR), tumor regression grade (TRG), surgical margin, side effects, and overall survival. Read More

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http://dx.doi.org/10.2147/CMAR.S239420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152553PMC

A case report on clozapine-induced ventricular ectopics: a fatal adverse drug reaction.

J Basic Clin Physiol Pharmacol 2020 Apr 17;31(3). Epub 2020 Apr 17.

Indo Soviet Friendship College of Pharmacy - Pharmacy Practice, Moga, Punjab, India.

Background Clozapine is one of the most efficacious antipsychotic drug used for the treatment-resistant schizophrenia; it is sometimes associated with serious adverse reactions like agranulocytosis, myocarditis, cardiac rhythm disturbances, etc. Case presentation A 30-year-old patient with a primary diagnosis of paranoid schizophrenia (ICD code - F20.05) was on regular prescription for 6 years. Read More

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http://dx.doi.org/10.1515/jbcpp-2019-0339DOI Listing

Consensus statement on the use of clozapine during the COVID-19 pandemic.

J Psychiatry Neurosci 2020 05;45(3):222-223

From the Metro South Addiction and Mental Health Service, Brisbane, Australia (Siskind); the University of Queensland, School of Clinical Medicine, Brisbane, Australia (Siskind, Myles); the Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada (Honer); the University of Adelaide, School of Medicine, Adelaide, Australia (Clark, Kane); the The Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, NY, USA (Correll, Kane); the Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry and Molecular Medicine, Hempstead, NY, USA (Correll); Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany (Correll); the Department of Psychiatry, Psychotherapy and Psychosomatics of the University Augsburg, Augsburg, Germany (Hassan); the Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (Howes, MacCabe); the MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK (Howes); the Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK (Howes); the Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA (Kelly); the Bronx Westchester Medical Group, New York, NY, USA (Laitman); the North Region & Department of Psychosis, Institute of Mental Health, Singapore (Lee); the Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore (Lee); the Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen (Nielsen); the Mental Health Service Noord-Holland-Noord, Alkmaar, The Netherlands (Schulte); the South London and Maudsley NHS Foundation Trust, Pharmacy Department, Maudsley Hospital, London, UK (Taylor); the University of Bordeaux, INSERM, Bordeaux Population Health Research Center, Bordeaux, France (Verdoux); the Menzies Health Institute Queensland, Griffith University, Brisbane, Australia (Wheeler); the MGH Schizophrenia Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA (Freudenreich); and the Harvard Medical School, Boston, MA, USA (Freudenreich).

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http://dx.doi.org/10.1503/jpn.200061DOI Listing

[Incidental finding of leukopenia - directly to the hematologist?]

MMW Fortschr Med 2020 Apr;162(7):38-41

Labor für Leukämiediagnostik, Medizinische Klinik und Poliklinik III, Klinikum der Universität München, Marchioninistr. 15, D81377, München, Deutschland.

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http://dx.doi.org/10.1007/s15006-020-0389-8DOI Listing

A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology.

Psychother Psychosom 2020 Apr 14:1-15. Epub 2020 Apr 14.

Department of Internal Medicine, Dermatology and Psychiatry, University of La Laguna, San Cristóbal de La Laguna, Spain.

Using Richardson and Davidson's model and the sciences of pharmacokinetics and clinical pharmacopsychology, this article reviewed the: (1) poor life expectancy associated with treatment-resistant schizophrenia (TRS), which may be improved in patients who adhere to clozapine; (2) findings that clozapine is the best treatment for TRS (according to efficacy, effectiveness and well-being); and (3) potential for clozapine to cause vulnerabilities, including potentially lethal adverse drug reactions such as agranulocytosis, pneumonia, and myocarditis. Rational use requires: (1) modification of the clozapine package insert worldwide to include lower doses for Asians and to avoid the lethality associated with pneumonia, (2) the use of clozapine levels for personalizing dosing, and (3) the use of slow and personalized titration. This may make clozapine as safe as possible and contribute to increased life expectancy and well-being. Read More

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http://dx.doi.org/10.1159/000507638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206357PMC

Eosinophilic pneumonia during treatment with clozapine: reports from a retrospective case series.

Int Clin Psychopharmacol 2020 Apr 8. Epub 2020 Apr 8.

Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Yamaguchi, Japan.

Clozapine is an atypical antipsychotic known to cause multiple hematologic abnormalities, most seriously agranulocytosis, but also notably eosinophilia. It is considered as an allergic reaction with a spontaneous remission, however, sometimes, it may predict subsequent major inflammatory complications. The aim of this study was to investigate the relationship between clozapine usage and drug-induced pneumonia based on characteristic respiratory symptoms and radiological findings, retrospectively in 69 Japanese treatment-resistant schizophrenia patients. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000311DOI Listing

[Cyclic neutropenia: a case report].

Authors:
Y Liu J Fu X B Guan

Zhonghua Kou Qiang Yi Xue Za Zhi 2020 Apr;55(4):264-265

Department of Oral Medicine, Capital Medical University School of Stomatology, Beijing 100050, China.

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http://dx.doi.org/10.3760/cma.j.cn112144-20191114-00410DOI Listing

[Idiosyncratic drug-induced agranulocytosis: 7 year-analysis in a French university hospital].

Ann Pharm Fr 2020 May 10;78(3):230-241. Epub 2020 Feb 10.

Centre régional de pharmacovigilance, CHU de Grenoble-Alpes, 38000 Grenoble, France.

Introduction: Idiosyncratic drug-induced agranulocytosis is a rare but potentially serious haematological disorder. The pathophysiological mechanisms are complex and poorly understood. We aimed at investigating agranulocytosis drug related causes from the myelograms with "myeloid maturation arrest" performed in our university hospital over the last seven years. Read More

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http://dx.doi.org/10.1016/j.pharma.2020.02.004DOI Listing

Accuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients with febrile neutropenia: A systematic review and meta-analysis.

Crit Rev Oncol Hematol 2020 May 3;149:102922. Epub 2020 Mar 3.

Department of Emergency Medicine, University of Ottawa, Ottawa, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.

We compared the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for identifying serious complications in febrile neutropenia patients. We searched MEDLINE, PubMed, EMBASE, and Cochrane Database of Systematic Reviews from inception to March 19, 2019. Two reviewers independently screened citations, extracted data, and assessed quality. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102922DOI Listing

Clinical experience of treating Graves' hyperthyroidism complicated with malignancy-The possible role of potassium iodide for avoiding the risk of thionamide-associated neutropenia.

Endocr J 2020 Apr 2. Epub 2020 Apr 2.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

The treatment of Graves' hyperthyroidism (GD) complicated with malignancy is challenging, as anti-thyroid thionamide drugs (ATDs) and anti-cancer chemotherapy are both associated with a risk of neutropenia. Treatment with conventional ATDs, radioactive iodine (RAI) or potassium iodide (KI) was attempted in 8 patients with malignancy (34-80 years of age; 2 males and 6 females) in whom GD had been fortuitously diagnosed during a detailed systematic examination. Three patients requiring surgery were initially treated conventionally with methylmercaptoimidazole (MMI), MMI and KI or RAI (group A; one patient each). Read More

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http://dx.doi.org/10.1507/endocrj.EJ20-0016DOI Listing

Dose Adjustment of Oxaliplatin Based on Renal Function in Patients With Metastatic Colorectal Cancer.

Anticancer Res 2020 Apr;40(4):2379-2386

Department of Pharmacy, Gifu University Hospital, Gifu, Japan.

Background/aim: The effect of renal dysfunction on the toxicity and efficacy of oxaliplatin remains unclear. We investigated the association between creatinine clearance (Ccr), a marker of renal function, and the toxicity and efficacy of oxaliplatin in patients with metastatic colorectal cancer (mCRC).

Patients And Methods: Patients with mCRC who received oxaliplatin-based chemotherapy as first-line treatment were included in this study. Read More

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http://dx.doi.org/10.21873/anticanres.14207DOI Listing

Agranulocytosis Induced by Tamoxifen in a Breast Cancer Patient.

Breast Care (Basel) 2020 Feb 20;15(1):72-74. Epub 2019 Jun 20.

Oncology Department, Paul Strauss Comprehensive Cancer Center, Strasbourg, France.

Background: The main side effects of tamoxifen are menopausal symptoms. We report a case of agranulocytosis induced by tamoxifen in a 33-year-old woman treated in the adjuvant setting.

Case Presentation: Ten days after the beginning of tamoxifen treatment, the patient complained of asthenia and mucositis. Read More

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http://dx.doi.org/10.1159/000500708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098272PMC
February 2020

Safety of antithyroid drugs in pregnancy: update and therapy implications.

Expert Opin Drug Saf 2020 May 1;19(5):565-576. Epub 2020 Apr 1.

Endocrinology and Diabetes Department, Prince Charles Hospital, Cwm Taf University Health Board, Merthyr Tydfil, UK.

: The thionamide antithyroid drugs, methimazole (MMI), its pro-drug derivative carbimazole (CMZ), and propylthiouracil (PTU) are the mainstay of treatment for hyperthyroidism in pregnancy. However, antithyroid drugs carry risks of adverse effects that can affect fetal and maternal well-being.: This review provides an update on the safety of antithyroid drugs in pregnancy, focusing on the most serious concerns of severe liver disease and congenital anomalies. Read More

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http://dx.doi.org/10.1080/14740338.2020.1748007DOI Listing

Severe Neutropenia and Agranulocytosis Related to Antithyroid Drugs: A Study of 30 Cases Managed in A Single Reference Center.

Medicines (Basel) 2020 Mar 19;7(3). Epub 2020 Mar 19.

Departments of Internal Medicine, Strasbourg University Hospitals, 67000 Strasbourg, France.

Background: The most important series devoted to antithyroid drug-induced severe neutropenia and agranulocytosis are Japanese studies, almost specifically in relation to the intake of methimazole. The clinical data of 30 Caucasian patients followed up for antithyroid drug-induced neutropenia at a third-level hospital are reported. The data of 30 patients with idiosyncratic antithyroid drug-induced neutropenia and agranulocytosis from a cohort study on drug-induced neutropenia and agranulocytosis conducted at the University Hospital of Strasbourg (France) were retrospectively reviewed. Read More

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http://dx.doi.org/10.3390/medicines7030015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151575PMC

[COVID-19 with post-chemotherapy agranulocytosis in childhood acute leukemia: a case report].

Zhonghua Xue Ye Xue Za Zhi 2020 04;41(4):341-343

Department of Hematology and Oncology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China.

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.0004DOI Listing

Clozapine-induced anemia: A case-report
.

Int J Clin Pharmacol Ther 2020 May;58(5):289-292

Clozapine, an atypical antipsychotic, can cause potentially life-threating side effects such as agranulocytosis. Our case presents a picture of severe anemia without any depression of the white cells or platelet lines. A 36-year-old man with treatment-resistant schizophrenia was admitted to the Psychiatric Unit for therapy assessment. Read More

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http://dx.doi.org/10.5414/CP203679DOI Listing

Dapsone Induced Agranulocytosis and Hemolytic Anemia in Immune Thrombocytopenic Purpura.

Indian J Pediatr 2020 Mar 5. Epub 2020 Mar 5.

Department of Pathology, JN Medical College, KAHER's University, Belagavi, India.

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http://dx.doi.org/10.1007/s12098-020-03226-xDOI Listing

Neonatal sepsis with neutropenia: granulocyte-colony stimulating factor (G-CSF).

Rev Assoc Med Bras (1992) 2020;66(1):3-10. Epub 2020 Feb 27.

. Associação Médica Brasileira, São Paulo, SP, Brasil.

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http://dx.doi.org/10.1590/1806-9282.66.1.3DOI Listing

Antibiotic prescribing and outcomes in cancer patients with febrile neutropenia in the emergency department.

PLoS One 2020 28;15(2):e0229828. Epub 2020 Feb 28.

Emergency Department, Hôpital Saint-Louis, Paris, France.

Introduction: The benefit of reducing the time of antibiotic initiation in the emergency department (ED) for neutropenic patients is controversial and the research on the impact of antibiotic adherence to international guidelines in the ED is scarce. We aimed to investigate the effect of antibiotic timing and appropriateness on outcomes in patients with febrile neutropenia (FN) and to assess the performance of the MASCC risk-index to risk-stratify such patients in the ED.

Methods: We prospectively identified patients with FN who presented to our ED and assessed their Multinational Association of Supportive Care in Cancer (MASCC) risk-index. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048306PMC

A Look at Genetic Linkage between Clozapine-induced Agranulocytosis, Malignant Hyperthermia, Neuroleptic Malignant Syndrome, and Statin-induced Myopathy.

Innov Clin Neurosci 2019 Nov;16(11-12):28-31

Dr. Pothen and Dr. Kansal are with Ocean Medical Center, Hackensack Meridian Health in Brick, New Jersey.

Clozapine-induced agranulocytosis, malignant hyperthermia (MH), statin-induced myopathy, and neuroleptic malignant syndrome (NMS) are all serious drug reactions with significant overlap in terms of clinical symptomatology. The use of clozapine can lead to neutropenia, as well as the development of NMS; thus, it seemed logical to explore a possible common genetic background for the development of these two adverse effects. Furthermore, due to the overwhelming clinical resemblance between NMS, MH, and statin-induced myopathy, we decided specifically to search for a common genetic background in the development of these conditions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006864PMC
November 2019

Efficacy and safety of cefoperazone-sulbactam in empiric therapy for febrile neutropenia: A systemic review and meta-analysis.

Medicine (Baltimore) 2020 Feb;99(8):e19321

Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan.

Purpose: This meta-analysis assessed the clinical efficacy and safety of cefoperazone-sulbactam for empiric therapy febrile neutropenia.

Methods: The PubMed, Web of Science, EBSCO, Cochrane Library, Ovid Medline, EMBASE, and ClinicalTrial.gov database were searched through May 10, 2019. Read More

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http://dx.doi.org/10.1097/MD.0000000000019321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034635PMC
February 2020

Genetic associations with clozapine-induced myocarditis in patients with schizophrenia.

Transl Psychiatry 2020 Jan 27;10(1):37. Epub 2020 Jan 27.

MRC Centre for Drug Safety Science, Wolfson Centre for Personalised Medicine, University of Liverpool, The Royal Liverpool and Broadgreen University Hospitals NHS Trust, and Liverpool Health Partners, Liverpool, UK.

Clozapine is the most effective antipsychotic drug for schizophrenia, yet it can cause life-threatening adverse drug reactions, including myocarditis. The aim of this study was to determine whether schizophrenia patients with clozapine-induced myocarditis have a genetic predisposition compared with clozapine-tolerant controls. We measured different types of genetic variation, including genome-wide single-nucleotide polymorphisms (SNPs), coding variants that alter protein expression, and variable forms of human leucocyte antigen (HLA) genes, alongside traditional clinical risk factors in 42 cases and 67 controls. Read More

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http://dx.doi.org/10.1038/s41398-020-0722-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026069PMC
January 2020

Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss.

BMC Med Genet 2020 02 17;21(1):35. Epub 2020 Feb 17.

Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia.

Background: We report a large family with four successive generations, presenting with a complex phenotype of severe congenital neutropenia (SCN), partially penetrant monocytosis, and hearing loss of varying severity.

Methods: We performed whole exome sequencing to identify the causative variants. Sanger sequencing was used to perform segregation analyses on remaining family members. Read More

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http://dx.doi.org/10.1186/s12881-020-0971-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026993PMC
February 2020

Comparison of two different anti-infectious approaches after high-dose chemotherapy and autologous stem cell transplantation for hematologic malignancies in a 12-year period in British Hospital, Uruguay.

Ann Hematol 2020 Apr 15;99(4):877-884. Epub 2020 Feb 15.

Department: Hematology, Hospital Britanico, Av Italia 2420, 11300, Montevideo, Uruguay.

Autologous stem cell transplant (ASCT) is a widely used and safe procedure to treat mostly hematologic diseases. These patients are at risk of infectious complications, which represents a major cause of morbidity and it is the second cause of mortality. This retrospective 12-year analysis of the incidence, type, and severity of infections in 266 consecutive unselected ASCT patients at our institution provides novel information addressing this issue. Read More

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http://dx.doi.org/10.1007/s00277-020-03947-1DOI Listing
April 2020
2.634 Impact Factor

Utility of anaerobic bottles for the diagnosis of bloodstream infections.

BMC Infect Dis 2020 Feb 14;20(1):142. Epub 2020 Feb 14.

Department of Infectious Diseases, Saint-Louis Hospital, Paris, University of Paris Diderot Paris 7, Sorbonne Paris Cité, INSERM U941, Paris, France.

Background: Obligate anaerobes usually account for less than 10% of bacteria recovered from blood cultures (BC). The relevance of routine use of the anaerobic bottle is under debate. The aim of this study was to evaluate the utility of anaerobic bottles for the diagnosis of bloodstream infections (BSI). Read More

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http://dx.doi.org/10.1186/s12879-020-4854-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023744PMC
February 2020

Patient-specific factors modulate leukocyte response in dimethyl fumarate treated MS patients.

PLoS One 2020 11;15(2):e0228617. Epub 2020 Feb 11.

University of Texas Southwestern Medical Center at Dallas, Department of Neurology and Neurotherapeutics, Dallas, Texas, United States of America.

Objective: Determine if patient-specific factors modulate absolute lymphocyte count (ALC), neutrophil count (ANC), and/or Neutrophile-lymphocyte ratio (NLR) in Dimethyl Fumarate (DMF) treated patients.

Methods: A retrospective study of patients who initiated DMF between 2013-2018. A multicenter study of two MS clinics: Charlottesville, VA (UVA) and Dallas, TX (DaVA). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228617PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012426PMC

Haematologic malignancies associated with clozapine all other antipsychotic agents: a pharmacovigilance study in VigiBase.

Psychol Med 2020 Feb 10:1-8. Epub 2020 Feb 10.

Department of Pharmacology, Caen University Hospital, Caen, F-14000, France.

Background: Clozapine is mainly used in patients with treatment-resistant schizophrenia and may lead to potentially severe haematologic adverse events, such as agranulocytosis. Whether clozapine might be associated with haematologic malignancies is unknown. We aimed to assess the association between haematologic malignancies and clozapine using Vigibase®, the WHO pharmacovigilance database. Read More

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http://dx.doi.org/10.1017/S0033291720000161DOI Listing
February 2020

Assessing the burden of laboratory-confirmed respiratory syncytial virus infection in a population cohort of Australian children through record linkage.

J Infect Dis 2020 Feb 7. Epub 2020 Feb 7.

Wesfarmers Centre of Vaccine and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, West Perth, Western Australia, Australia.

Background: Significant progress has been made towards an effective respiratory syncytial virus (RSV) vaccine. Age-stratified estimates of RSV burden are urgently needed for vaccine implementation. Current estimates are limited to small cohorts or clinical coding data only. Read More

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http://dx.doi.org/10.1093/infdis/jiaa058DOI Listing
February 2020

Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B alleles.

PLoS One 2020 6;15(2):e0220754. Epub 2020 Feb 6.

Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.

Introduction: Adverse drug reactions have been linked with HLA alleles in different studies. These HLA proteins play an essential role in the adaptive immune response for the presentation of self and non-self peptides. Anti-thyroid drugs methimazole and propylthiouracil have been associated with drug induced agranulocytosis (severe lower white blood cell count) in patients with B*27:05, B*38:02 and DRB1*08:03 alleles in different populations: Taiwanese, Vietnamese, Han Chinese and Caucasian. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220754PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004376PMC

Phase II study of safety and efficacy of BEB (bendamustine, etoposide, and busulfan) conditioning regimen for autologous stem cell transplantation in non-Hodgkin lymphoma.

Ann Hematol 2020 Apr 5;99(4):819-828. Epub 2020 Feb 5.

Division of Hematology-Oncology, Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea.

Autologous stem cell transplant (ASCT) is an effective treatment for non-Hodgkin lymphoma (NHL). However, recent supply issues and toxicity of carmustine have necessitated a new conditioning regimen. We conducted a multicenter, phase II study of BEB (busulfan, etoposide, and bendamustine) conditioning regimen for ASCT in patients with NHL. Read More

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http://dx.doi.org/10.1007/s00277-020-03942-6DOI Listing

Eosinopenia as a diagnostic marker of bloodstream infection in a general internal medicine setting: a cohort study.

BMC Infect Dis 2020 Jan 30;20(1):85. Epub 2020 Jan 30.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Clinical Education Building, Kitakobayashi 880, Mibu, Shimotsuga, Mibu, 321-0293, Japan.

Background: Little is known about the potential use of the eosinophil count as a predictive marker of bloodstream infection. In this study, we aimed to assess the reliability of eosinopenia as a predictive marker of bloodstream infection.

Methods: This retrospective cohort study was performed in the outpatient department and general internal medicine department of a tertiary university hospital in Japan. Read More

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http://dx.doi.org/10.1186/s12879-020-4814-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990586PMC
January 2020

Mosaic Small Supernumerary Marker Chromosome Derived from Five Discontinuous Regions of Chromosome 8 in a Patient with Neutropenia and Oral Aphthous Ulcer.

Cytogenet Genome Res 2020 24;160(1):11-17. Epub 2020 Jan 24.

Small supernumerary marker chromosomes (sSMCs) are characterized as additional centric chromosome fragments which are too small to be classified by cytogenetic banding alone and smaller than or equal to the size of chromosome 20 of the same metaphase spread. Here, we report a patient who presented with slight neutropenia and oral aphthous ulcers. A mosaic de novo sSMC, which originated from 5 discontinuous regions of chromosome 8, was detected in the patient. Read More

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http://dx.doi.org/10.1159/000505805DOI Listing

Human leukocyte antigen DRB1*04:05 and clozapine-induced agranulocytosis/granulocytopenia.

Aust N Z J Psychiatry 2020 May 22;54(5):545-546. Epub 2020 Jan 22.

Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan.

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http://dx.doi.org/10.1177/0004867419900296DOI Listing

Cytogenetics and mutations could predict outcome in relapsed and refractory acute myeloid leukemia patients receiving BCL-2 inhibitor venetoclax.

Ann Hematol 2020 Mar 21;99(3):501-511. Epub 2020 Jan 21.

Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Venetoclax, a selective B cell leukemia/lymphoma-2 (BCL2) inhibitor, has recently shown activity in relapsed or refractory (R/R) acute myeloid leukemia (AML). Effective biomarkers for identifying patients most likely to respond to venetoclax-based treatment are of clinical utility. In this study, we aimed to evaluate the efficacy and safety profiles of venetoclax-based therapy in a total 40 R/R AML patients and identify the potentially predictive factors for response. Read More

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http://dx.doi.org/10.1007/s00277-020-03911-zDOI Listing

Decitabine: An effective and safe treatment for myelodysplastic syndrome and acute myeloid leukemia.

J Cancer Res Ther 2019 ;15(7):1471-1476

Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Objective: Decitabine is reported to be valuable in treating multiple malignant blood diseases. However, the application of decitabine in myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) has not been fully examined. Thus, our study aimed to investigate the clinical efficacy and safety of decitabine in treating such patients. Read More

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http://dx.doi.org/10.4103/0973-1482.204849DOI Listing
January 2019

The History of Deferiprone (L1) and the Paradigm of the Complete Treatment of Iron Overload in Thalassaemia.

Mediterr J Hematol Infect Dis 2020 1;12(1):e2020011. Epub 2020 Jan 1.

Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus.

Deferiprone (L1) was originally designed, synthesised and screened in vitro and in vivo in 1981 by Kontoghiorghes G. J. following his discovery of the novel alpha-ketohydroxypyridine class of iron chelators (1978-1981), which were intended for clinical use. Read More

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http://dx.doi.org/10.4084/MJHID.2020.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951358PMC
January 2020

[Epidemiology of early infections after autologous hematopoietic stem cell transplantation. ].

Orv Hetil 2020 Jan;161(3):103-109

Országos Hematológiai és Infektológiai Intézet, Hematológiai Osztály, Dél-pesti Centrumkórház Budapest, Albert Flórián út 5-7., 1097.

Autologous hemopoietic stem cell transplantation remains a promising therapy in certain malignant and non-malignant conditions. The procedure, however, will increase the risk of complications, most notably early and late infections. To analyze the frequency and spectrum of pathogens in early (<+100 days) post-transplant infections and to evaluate risk factors for mortality. Read More

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http://dx.doi.org/10.1556/650.2020.31638DOI Listing
January 2020

Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis and agranulocytosis in a patient with Graves' disease.

Endocrinol Diabetes Metab Case Rep 2020 Jan 8;2020. Epub 2020 Jan 8.

Department of Endocrinology and Diabetes, Beaumont Hospital Dublin, Dublin, Ireland.

Summary: This case is the first to describe a patient who experienced concomitant agranulocytosis and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis as an adverse effect of propylthiouracil treatment for Graves' disease. A 42-year-old female with Graves' disease presented to the emergency department (ED) with a 2-week history of fevers, night sweats, transient lower limb rash, arthralgia, myalgia and fatigue. She had been taking propylthiouracil for 18 months prior to presentation. Read More

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http://dx.doi.org/10.1530/EDM-19-0135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993247PMC
January 2020

Should we optimize cytotoxic therapy by dosing to neutropenia? Lessons from TAS-102.

Authors:
P M Kasi A Grothey

Ann Oncol 2020 01;31(1):15-16

West Cancer Center and Research Institute, OneOncology, Germantown, Tennessee, USA. Electronic address:

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http://dx.doi.org/10.1016/j.annonc.2019.11.001DOI Listing
January 2020