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    24170 results match your criteria Agranulocytosis

    1 OF 484

    Minimization of the perianal infection rate of hematological malignancies with agranulocytosis by quality control circle activity and patient-hospital-student win-win concept.
    J Int Med Res 2018 Jan 1:300060517726863. Epub 2018 Jan 1.
    1 198153 Southern Medical University Nanfang Hospital , Guangzhou, Guangdong, China.
    Objective The agranulocytosis-associated perianal infection (PI) rate ranges from 60% to 100% among patients with hematopoietic malignancies. In this study, we assessed the efficacy of a quality control circle (QCC) to minimize the PI rate. Methods Among 274 patients with severe immunodeficiency (agranulocytosis of ≥2 weeks) in our bone marrow transplantation center, the PI rate was 17. Read More

    A Case of Levamisole-Induced Agranulocytosis.
    Case Rep Hematol 2018 11;2018:7341835. Epub 2018 Feb 11.
    Department of Internal Medicine, Creighton University, Omaha, NE, USA.
    A sixty-eight-year-old male with a past medical history of recurrent cocaine use presented to the emergency department with recurrent diarrhea and was found to have a white blood cell (WBC) count of 1.9 × 10/L with agranulocytosis (absolute neutrophil count (ANC) of 95 cell/mm). At admission, the patient disclosed that he used cocaine earlier during the day, and a urine drug screen tested positive for this. Read More

    Enterocolitis in Patients with Cancer Treated with Docetaxel.
    Anticancer Res 2018 04;38(4):2443-2446
    Department of Medical Oncology, University Hospital of Besançon, Besançon, France.
    Background: Enterocolitis is a rare, but serious gastrointestinal complication associated with docetaxel-based chemotherapy in patients with cancer. The incidence, clinical presentation and outcome of enterocolitis in patients with cancer treated with docetaxel-based chemotherapy was assessed in this study Patients and Methods: All patients treated with docetaxel for cancer between January 2010 and December 2014 at the University Hospital of Besançon were identified and their medical records reviewed.

    Results: During this period, 1,227 patients received docetaxel chemotherapy and gastrointestinal events occurred in 381 (31. Read More

    Clozapine-related neutropenia, myocarditis and cardiomyopathy adverse event reports in Australia 1993-2014.
    Psychopharmacology (Berl) 2018 Mar 27. Epub 2018 Mar 27.
    Metro South Addiction and Mental Health Service, 228 Logan Road, Woolloongabba, QLD, 4102, Australia.
    Rationale: Clozapine is the gold-standard medicine for treating refractory schizophrenia but there are some notable serious adverse events (AE). We aimed to analyse reported rates of clozapine cardiac and haematological AEs in Australia.

    Methods: Using data from the Therapeutic Goods Administration, we examined all reported clozapine AEs (1993-2014) with a specific focus on neutropenia, myocarditis and cardiomyopathy. Read More

    Venetoclax-Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia.
    N Engl J Med 2018 03;378(12):1107-1120
    From the Peter MacCallum Cancer Centre, Royal Melbourne Hospital, and University of Melbourne, Melbourne, VIC (J.F.S.), and the John Curtin School of Medical Research, Australian National University, Canberra, ACT (J.D.) - all in Australia; the University of California School of Medicine, San Diego (T.J.K.), and Genentech, South San Francisco (E.A.P., Y.L., M. Mobasher) - both in California; University Hospital Cologne and the Center for Integrated Oncology Cologne-Bonn, Cologne, Germany (B.E.); St. James's University Hospital, Leeds (P.H.), and F. Hoffmann-La Roche, Welwyn Garden City (M.B., K.H.) - both in the United Kingdom; Segal Cancer Center, Lady Davis Institute, Jewish General Hospital, Montreal (S.A.), and the Departments of Medicine and Oncology, University of Calgary, Calgary, AB (C.O.) - all in Canada; Memorial Sloan Kettering Cancer Center, New York (J.G.); the Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz, Poland (T.R.); Hospital Universitario 12 de Octubre, Madrid (J.D.S.); Medical University of Vienna, Department of Medicine I, Division of Hematology and Hemostaseology, Vienna (U.J.); the Department of Hematology, Centre Hospitalier Universitaire Montpellier, Montpellier, France (G.C.); the Department of Onco-Hematology, Division of Hematology, Niguarda Cancer Center, Niguarda Hospital, Milan (M. Montillo); AbbVie, North Chicago, IL (R.H.); and the Department of Hematology, Cancer Center Amsterdam, Academic Medical Center, Amsterdam (A.P.K.).
    Background: Venetoclax inhibits BCL2, an antiapoptotic protein that is pathologically overexpressed and that is central to the survival of chronic lymphocytic leukemia cells. We evaluated the efficacy of venetoclax in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia.

    Methods: In this randomized, open-label, phase 3 trial, we randomly assigned 389 patients to receive venetoclax for up to 2 years (from day 1 of cycle 1) plus rituximab for the first 6 months (venetoclax-rituximab group) or bendamustine plus rituximab for 6 months (bendamustine-rituximab group). Read More

    Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor.
    Case Rep Med 2018 23;2018:8439791. Epub 2018 Jan 23.
    Department of Internal Medicine, Hiroshima Kyoritsu Hospital, Hiroshima, Japan.
    When elderly patients are prescribed many different medications, the risk for developing serious adverse events should be kept in mind. One of these adverse events is agranulocytosis, which, although rare, can be life-threatening if left untreated. The majority of agranulocytosis cases are caused by drugs, including antibiotics. Read More

    Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature.
    Case Rep Endocrinol 2018 10;2018:4135940. Epub 2018 Jan 10.
    Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
    Aim: To present a case of Graves' disease complicated by methimazole induced agranulocytosis treated with therapeutic plasma exchange (TPE) and review of the literature.

    Case Presentation: A 21-year-old patient with a history of Graves' disease presented to the endocrine clinic. His history was significant for heat intolerance, weight loss, and tremors. Read More

    Clozapine-induced cardiomyopathy and myocarditis monitoring: A systematic review.
    Schizophr Res 2018 Mar 13. Epub 2018 Mar 13.
    Pharmacy Services, Mayo Clinic, Rochester, MN, United States. Electronic address:
    The use of clozapine requires monitoring the absolute neutrophil count because of the risk of agranulocytosis, but other potentially fatal adverse events associated with clozapine (specifically, myocarditis and cardiomyopathy) do not have mandatory procedures. We performed a systematic review of English-language articles to synthesize an evidence-based approach for myocarditis and cardiomyopathy monitoring. Articles published from January 1988 through February 2017 were identified through a search of Ovid MEDLINE, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Web of Science, Scopus, and Google Scholar. Read More

    Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases.
    Case Rep Hematol 2018 10;2018:5846398. Epub 2018 Jan 10.
    Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
    A 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates. Read More

    New findings in pharmacogenetics of schizophrenia.
    Curr Opin Psychiatry 2018 May;31(3):200-212
    Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health.
    Purpose Of Review: This review highlights recent advances in the investigation of genetic factors for antipsychotic response and side effects.

    Recent Findings: Antipsychotics prescribed to treat psychotic symptoms are variable in efficacy and propensity for causing side effects. The major side effects include tardive dyskinesia, antipsychotic-induced weight gain (AIWG), and clozapine-induced agranulocytosis (CIA). Read More

    DRESS syndrome: a detailed insight.
    Hosp Pract (1995) 2018 Mar 15:1-11. Epub 2018 Mar 15.
    a Department of Clinical Pharmacology , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry , India.
    Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious and potentially fatal adverse effect to therapeutic medications. The incidence of this condition varies among different ethnicities because of the difference in the genetic makeup. Though fever, rash and eosinophilia are essential features for the diagnosis of this syndrome, these vary from patient to patient along with the involvement of various organs such as liver, kidney, lungs, pancreas, etc. Read More

    ELANE gene mutation-induced cyclic neutropenia manifesting as recurrent fever with oral mucosal ulcer: A case report.
    Medicine (Baltimore) 2018 Mar;97(10):e0031
    Department of Pediatrics, First Hospital Affiliated to Bengbu Medical College, Bengbu Anhui, China.
    Background: Cyclic neutropenia (CyN) is a rare hematological disease. Herein, a CyN girl, aged 3 years and 2 months, with recurrent fever and oral mucosal ulcer caused by neutrophil elastase (ELANE) gene mutation is reported.

    Case Presentation: A 3 years and 2 months old girl presented with recurrent fever and oral mucosal ulcer for 1 year. Read More

    Sudden death in schizophrenia.
    Curr Opin Psychiatry 2018 May;31(3):169-175
    VA Boston Healthcare System.
    Purpose Of Review: To examine the recent literature regarding sudden death in patients with schizophrenia and synthesize salient conclusions based on this evidence.

    Recent Findings: Sudden cardiac death (SCD) is the largest subset of sudden unexpected death (SUD), with up to 40% of SUD from cardiovascular causes. SCD has been associated with exposure to both first and second-generation antipsychotics. Read More

    Clozapine Rechallenge After Major Adverse Effects: Clinical Guidelines Based on 259 Cases.
    Am J Ther 2018 Mar/Apr;25(2):e218-e223
    Mental Health Centre Glostrup, Copenhagen University Hospital, Copenhagen, Denmark.
    Background: Clozapine is widely prescribed for treatment-refractory schizophrenia, but its use is limited by many potentially life-threatening adverse effects. The risk of rechallenge after these complications has never been comprehensively assessed in controlled studies. Thus, clinical guidelines must rely on the published case reports. Read More

    [Role of Pharmacists in Completion of Adjuvant Cisplatin-Vinorelbine Chemotherapy in Japanese Patients with Non-small Cell Lung Cancer].
    Yakugaku Zasshi 2018 ;138(3):437-442
    Department of General Thoracic Surgery, Kyorin University School of Medicine.
     Adjuvant cisplatin-vinorelbine chemotherapy has been shown to be effective in patients with completely resected non-small cell lung cancer (NSCLC) in several Phase III trials, but not yet in the Japanese population. Pharmacists are expected to assist patients with completion of adjuvant chemotherapy. The aim of this retrospective study was to evaluate the compliance with and safety of adjuvant cisplatin-vinorelbine chemotherapy in Japanese patients and to evaluate the contribution of pharmacists to completion of treatment. Read More

    Potentially fatal outcomes associated with clozapine.
    Schizophr Res 2018 Mar 1. Epub 2018 Mar 1.
    VA Boston Healthcare System, 940 Belmont St., Bld 2, Brockton, MA 02301, USA; Harvard South Shore Psychiatry Residency Training Program, 940 Belmont St., Bld 5 116-A7, Brockton, MA, 02301, USA; Harvard Medical School, 25 Shattuck St., Boston, MA 02115, USA.
    Clozapine has been shown to be the most efficacious therapy for treatment resistant schizophrenia, estimated at one third of all schizophrenia cases. There is significant morbidity and mortality associated with clozapine including risk of agranulocytosis, aspiration pneumonia, bowel ischemia, myocarditis, seizures, and weight gain. Here we present a case of a 62-year-old man with chronic paranoid schizophrenia refractory to numerous antipsychotics who was started on clozapine therapy during an acute inpatient psychiatric admission. Read More

    Clozapine Patients at the Interface between Primary and Secondary Care.
    Pharmacy (Basel) 2018 Feb 26;6(1). Epub 2018 Feb 26.
    School of Pharmacy, University College Cork, Cork T12 YN60, Ireland.
    Patients receiving clozapine must undergo routine blood monitoring to screen for neutropenia, and to monitor for potential agranulocytosis. In Cork University Hospital, Cork, Ireland, clozapine is dispensed in the hospital pharmacy and the pharmacists are not aware of co-prescribed medicines, potentially impacting upon patient safety. The aim of this study was to examine the continuity of care of patients prescribed clozapine. Read More

    A Feasibility Study of Capecitabine and Oxaliplatin for Patients with Stage II/III Colon Cancer -ACTOR Study.
    Anticancer Res 2018 03;38(3):1741-1747
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
    Background/aim: Past studies have suggested that adjuvant capecitabine and oxaliplatin (CAPOX) provides decreased tumor relapse and longer survival in patients with curatively resected colon cancer. We report the first evidence of the feasibility of adjuvant CAPOX in Japanese patients with early colon cancer.

    Patients And Methods: Eligible patients had histologically-confirmed stage II/III colon cancer and received curative resection. Read More

    A Phase II Study of Irinotecan for Patients with Previously Treated Small-Cell Lung Cancer.
    Oncology 2018 14;94(4):223-232. Epub 2018 Feb 14.
    Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
    Objective: Chemotherapy with irinotecan plus cisplatin has shown promise in chemo-naïve small-cell lung cancer (SCLC) patients. However, irinotecan treatment for relapsed or refractory SCLC has not been adequately evaluated. This phase II study evaluated the appropriate treatment schedule of irinotecan as a single agent. Read More

    Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study.
    J Basic Clin Physiol Pharmacol 2018 Feb 13. Epub 2018 Feb 13.
    Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Laboratório de Farmacologia Clínica e Experimental (LaFaCE), Departamento de Farmacologia, Rua José Lourenço Kelmer, s/n. 36036-900, Juiz de Fora, MG, Brasil, Phone: +55 32 2102-3369; 55 32 2102-3210, Fax: +55 32 2102-3216.
    Background: Dipyrone is a non-narcotic analgesic/antipyretic widely used in some countries but prohibited in others due to suspected risk of agranulocytosis. The primary goal of this study was to evaluate hematological alterations in healthy adult volunteers after treatment with dipyrone.

    Methods: The study enrolled 30 healthy volunteers of both genders, aged 19-37 years. Read More

    Unique Effects of Clozapine: A Pharmacological Perspective.
    Adv Pharmacol 2018 12;82:137-162. Epub 2018 Jan 12.
    Geisel School of Medicine at Dartmouth, Hanover, NH, United States; Dartmouth Clinical and Translational Science Institute, Dartmouth College, Hanover, NH, United States. Electronic address:
    Schizophrenia is a heterogenous and severe neuropsychiatric disorder that affects nearly 1% of the population worldwide. Antipsychotic drugs are the mainstay of treatment, but not all patients with schizophrenia respond to treatment with these agents. Clozapine, the first atypical antipsychotic, is a highly effective medication for patients with schizophrenia who do not respond to other antipsychotics. Read More

    Febrile events in acute lymphoblastic leukemia: a prospective observational multicentric SEIFEM study (SEIFEM-2012/B ALL).
    Ann Hematol 2018 May 7;97(5):791-798. Epub 2018 Feb 7.
    Istituto di Ematologia, Università Cattolica del Sacro Cuore, Largo F. Vito, 1, 00168, Rome, Italy.
    The purpose of the present study is to estimate the current incidence of febrile events (FEs) and infectious episodes in acute lymphoblastic leukemia (ALL) and evaluate the outcome. We analyzed data on all FEs in a cohort of patients affected by ALL admitted to 20 Italian hematologic centers during 21 months of observation from April 1, 2012 to December 31, 2013. Data about treatment phase, steroids, neutropenia, type and site of infection, and outcome of infection were collected. Read More

    Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature.
    J Thromb Thrombolysis 2018 May;45(4):588-592
    Coronary Care Unit, "O.Barberi", "G.F.Ingrassia" Hospital, Palermo, Italy.
    This case report describes agranulocytosis immediately after oral administration of dabigatran in a 68 years old man with atrial fibrillation (AF). Dabigatran is an oral, reversible and competitive thrombin inhibitor that has shown promising results. In patients with atrial fibrillation of RE-LY study (Randomized Evaluation of Long-Term Anticoagulant Therapy), dabigatran administered at a dose of 150 mg, as compared with warfarin, was associated with lower rates of stroke and systemic embolism but similar rates of major hemorrhage. Read More

    Efficacy of Platinum-Based Chemotherapy for Relapsed Small-Cell Lung Cancer after Amrubicin Monotherapy in Elderly Patients and Patients with Poor Performance Status.
    Oncology 2018 31;94(4):207-214. Epub 2018 Jan 31.
    Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara-city, Japan.
    Background: Previous studies have shown amrubicin to be an effective first- or second-line treatment option for small-cell lung cancer (SCLC). However, there have been few studies reporting the efficacy of platinum-based chemotherapy after amrubicin therapy. We aimed to evaluate the efficacy of platinum-based chemotherapy as second-line treatment for elderly patients and those with SCLC with poor performance status (PS) previously treated with amrubicin monotherapy. Read More

    Efficacy and safety of nanoparticle albumin-bound paclitaxel monotherapy as second-line therapy of cytotoxic anticancer drugs in patients with advanced non-small cell lung cancer.
    Medicine (Baltimore) 2017 Dec;96(51):e9320
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui.
    Background: Nanoparticle albumin-bound paclitaxel (nab-PTX), which avoids toxicities associated with a vehicle used in solvent-based PTX, has already shown safety and efficacy in patients with non-small cell lung cancer (NSCLC).

    Methods: A phase II study was performed to assess the safety and efficacy of nab-PTX monotherapy as second-line chemotherapy after cytotoxic anticancer drugs for previously treated advanced NSCLC. Thirty-two patients with advanced NSCLC who had previously undergone 1 regimen of cytotoxic anticancer drugs were enrolled. Read More

    A retrospective comparison of and polyethylene glycol-conjugated asparaginase for the treatment of adolescents and adults with newly diagnosed acute lymphoblastic leukemia.
    Oncol Lett 2018 Jan 26;15(1):75-82. Epub 2017 Oct 26.
    Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China.
    Data from clinical trials suggest that polyethylene glycol-conjugated asparaginase (PEG asparaginase) should be recommended as a replacement for () asparaginase in the treatment of pediatric acute lymphoblastic leukemia (ALL) due to its prolonged effect, similar safety profile and convenience. The present study investigated the efficacy and safety of PEG asparaginase in adolescents and adults with newly diagnosed ALL. The clinical data of 122 patients, ≥14 years old with ALL, who received either PEG asparaginase or asparaginase as part of an induction regimen, were retrospectively analyzed. Read More

    Salvage chemoradiotherapy with cisplatin and vinorelbine for postoperative locoregional recurrence of non-small cell lung cancer.
    Medicine (Baltimore) 2017 Nov;96(47):e8635
    Department of Thoracic Oncology.
    Although a few investigators have demonstrated the effect of concurrent chemoradiotherapy (CRT) for postoperative recurrent non-small cell lung cancer (NSCLC), the outcome of this treatment remains unclear. The aim of this study was to elucidate the efficacy and tolerability of concurrent CRT with cisplatin (CDDP) and vinorelbine (VNR) in patients with postoperative locoregional recurrent NSCLC. A total of 40 patients who had received concurrent CRT with CDDP and VNR between January 1999 and December 2014 were retrospectively analyzed. Read More

    Dipyrone is the preferred nonopioid analgesic for the treatment of acute and chronic pain. A survey of clinical practice in German-speaking countries.
    Eur J Pain 2018 Jan 29. Epub 2018 Jan 29.
    Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital and Department of BioMedical Research, University of Bern, Bern, Switzerland.
    Purpose: Nonopioid analgesics are frequently used for the treatment of acute and chronic pain. Dipyrone is an alternative to NSAIDs and paracetamol, however, data on the frequency of its usage by anaesthesiologists in the perioperative and chronic pain setting are lacking and its adverse reactions are a matter of debate.

    Methods: The link to a questionnaire on the use of nonopioid analgesics (NSAIDs, COX-2 inhibitors, paracetamol, dipyrone) and the safety of dipyrone in the perioperative and chronic pain setting was mailed to anaesthesiologists and pain physicians. Read More

    [Clinical and bacteriological analysis of lymphoid tissue neoplasms patients with bacteria bloodstream infections].
    Zhonghua Xue Ye Xue Za Zhi 2017 Dec;38(12):1043-1048
    State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
    To investigate the clinical status of lymphoid tissue neoplasms patients with bacteria bloodstream infections, bacteriology and drug susceptibility results, and provide the basis for rational clinical anti-infection option. A retrospectively analysis of clinical data and bacterial susceptibility test results of patients with bacteria bloodstream infections from September 2010 to December 2014 was conducted. A total of 134 cases including 107 patients with bloodstream infections were enrolled. Read More

    [Effect of Pegfilgrastim Primary Prophylactic Administration on Relative Dose Intensity(RDI)in Postoperative Adjuvant Chemotherapy(TC Therapy)for Breast Cancer - A Single-Center, Retrospective Study].
    Gan To Kagaku Ryoho 2017 Dec;44(13):2087-2090
    Dept. of Surgery, Kanmon Medical Center.
    This study assessed the effect of pegfilgrastim in patients with early stage breast cancer who were receiving docetaxel and cyclophosphamide(TC)therapy(75mg/m / 2 docetaxel plus 600 mg/m2 cyclophosphamide). In total, 17 patients who were to receive 4 planned cycles of TC therapy every 3 weeks were included in this study. Of the 17 patients, 10 who received pegfilgrastim after January 2016 formed the Peg-G group and 7 who did not receive pegfilgrastim until December 2015 formed the control group. Read More

    Aplastic anemia secondary to propylthiouracil: A rare and life-threatening adverse effect.
    J Oncol Pharm Pract 2018 Jan 1:1078155217752079. Epub 2018 Jan 1.
    6596 Allegheny Health Network , Pittsburgh, USA.
    Background Propylthiouracil has been in use for more than half a century for the treatment of hyperthyroidism. While it is largely known to cause agranulocytosis, its association with aplastic anemia is rarely heard of. Our case will be the third in literature to suggest aplastic anemia as a manifestation of propylthiouracil, which unfortunately culminated in the death of the patient. Read More

    Clozapine-induced myocarditis.
    Oxf Med Case Reports 2018 Jan 9;2018(1):omx080. Epub 2018 Jan 9.
    Division of Cardiology, Department of Internal Medicine, The George Washington University, Washington, DC 20037, USA.
    Approved in 1989 for the management of treatment-resistant schizophrenia, Clozapine is a last-line atypical antipsychotic drug used with increasing frequency. In addition to its well-known side effect of agranulocytosis, this drug also carries with it rare but serious adverse cardiovascular risk of myocarditis. We present a patient on Clozapine who was admitted to the cardiology service with chest pain, ST segment elevations and elevated troponin concerning for acute myocardial infarction. Read More

    Risk of adverse events associated with front-line anti-myeloma treatment in Medicare patients with multiple myeloma.
    Ann Hematol 2018 May 15;97(5):851-863. Epub 2018 Jan 15.
    Department of Epidemiology, Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center in Houston, 1200 Pressler Street, RAS-E631, Houston, TX, 77030, USA.
    This study aims to examine the risks of adverse events associated with anti-multiple myeloma (MM) therapies in a large population-based cohort of elderly patients with MM. Patients diagnosed with advanced MM from 2005 through 2009 and receiving anti-MM therapy were identified from the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked data. We compared safety outcomes between novel agents (proteasome inhibitor (PI) and immunomodulatory drugs (IMiD)) and other therapies and between PI- or IMiD-based regimens and PI plus IMiD combination regimens. Read More

    HLA Association with Drug-Induced Adverse Reactions.
    J Immunol Res 2017 23;2017:3186328. Epub 2017 Nov 23.
    Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan.
    Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. Read More

    Type 1 autoimmune hepatitis presenting with severe autoimmune neutropenia.
    Ann Gastroenterol 2018 Jan-Feb;31(1):123-126. Epub 2017 Aug 4.
    4 Department of Internal Medicine, Hippokration General Hospital, Medical School Aristotle University of Thessaloniki (Petros Doumtsis, Evangelos Cholongitas, Theodora Oikonomou, Ioannis Goulis), Greece.
    Autoimmune hepatitis (AIH) is a progressive, chronic liver disease characterized by unresolving hepatocellular inflammation of autoimmune origin. The clinical spectrum may vary from asymptomatic presentation, to non-specific symptoms such as fatigue, arthralgias, nausea and abdominal pain, to acute severe liver disease. AIH is characterized by the presence of interface hepatitis and portal plasma cell infiltration on histological examination, hypergammaglobulinemia, and positive autoantibodies. Read More

    Cost-effectiveness of HLA-DQB1/HLA-B pharmacogenetic-guided treatment and blood monitoring in US patients taking clozapine.
    Pharmacogenomics J 2018 Jan 3. Epub 2018 Jan 3.
    Division of Nephrology, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
    Less than 1% of adult patients with schizophrenia taking clozapine develop agranulocytosis, and most of these cases occur within the first weeks of treatment. The human leukocyte antigen (HLA) region has been associated with genetic susceptibility to clozapine-induced agranulocytosis (single amino acid changes in HLA-DQB1 (126Q) and HLA-B (158T)). The current study aimed to evaluate the cost-effectiveness, from a healthcare provider's perspective, of an HLA genotype-guided approach in patients with treatment-resistant schizophrenia who were taking clozapine and to compare the results with the current absolute neutrophil count monitoring (ANCM) schemes used in the USA. Read More


    Outcomes of previously untreated elderly patients with AML: a propensity score-matched comparison of clofarabine vs. FLAG.
    Ann Hematol 2018 Apr 29;97(4):573-584. Epub 2017 Dec 29.
    Department of Pharmacy Services and Clinical Sciences, Michigan Medicine and University of Michigan College of Pharmacy, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA.
    The 5-year overall survival (OS) in patients ≥ 60 years old with acute myeloid leukemia (AML) remains < 10%. Clofarabine-based induction (CLO) provides an alternative to low-intensity therapy (LIT) and palliative care for this population, but supporting data are conflicted. Recently, our institution adopted the FLAG regimen (fludarabine, cytarabine, and granulocyte colony-stimulating factor) based on data reporting similar outcomes to CLO in elderly patients with AML unable to tolerate anthracycline-based induction. Read More

    Two-year observational study of deferiprone in superficial siderosis.
    CNS Neurosci Ther 2018 Mar 28;24(3):187-192. Epub 2017 Dec 28.
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
    Introduction: Superficial siderosis is a rare, neurodegenerative disease caused by toxic accumulation of hemosiderin on the surface of the brain and the spinal cord, most commonly from chronic subarachnoid hemorrhage.

    Aims: The aim of this study was to assess the clinical and radiological outcomes of superficial siderosis patients using deferiprone, a cell permeant iron chelator. Subjects obtained pre- and post-treatment brain MRIs and weekly laboratory tests. Read More

    Incidence of neutropenia and use of granulocyte colony-stimulating factors in multiple myeloma: is current clinical practice adequate?
    Ann Hematol 2018 Mar 27;97(3):387-400. Epub 2017 Dec 27.
    Department of Haematology, UZ Leuven, Leuven, Belgium.
    Although immunomodulatory drugs, alkylating agents, corticosteroids, protease inhibitors, and therapeutic monoclonal antibodies improve multiple myeloma outcomes, treatment burden is still an issue. Neutropenia is a known complication of cytotoxic cancer therapy and is often associated with infections; it is an important consideration in myeloma given the fact that patients often have a weakened immune system. The risk of febrile neutropenia increases with severe and persisting neutropenia. Read More

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