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    Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor: A Systematic Review.
    J Clin Psychopharmacol 2017 Apr 22. Epub 2017 Apr 22.
    From the *Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; †Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland; ‡Medical School, University of Bristol, Bristol; §National Psychosis Service, and ∥Pharmacy Department, South London and Maudsley NHS Foundation Trust; and ¶Institute of Pharmaceutical Science, King's College London; and #Department of Haematological Medicine, King's College Hospital, London, United Kingdom.
    Purpose/background: Clozapine is associated with hematological abnormalities, notably neutropenia, which may progress to agranulocytosis. Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been used to reduce the frequency and duration of clozapine-associated neutropenia. This review aims to explore the use, efficacy, and tolerability of these cytokines in the treatment of clozapine-associated agranulocytosis. Read More

    More than 25 years of genetic studies of clozapine-induced agranulocytosis.
    Pharmacogenomics J 2017 Apr 18. Epub 2017 Apr 18.
    Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
    Clozapine is one of the most effective atypical antipsychotic drugs prescribed to patients with treatment-resistant schizophrenia. Approximately 1% of patients experience potential life-threatening adverse effects in the form of agranulocytosis, greatly hindering its applicability in clinical practice. The etiology of clozapine-induced agranulocytosis (CIA) remains unclear, but is thought to be a heritable trait. Read More

    [Recurrent pulmonary infection and oral mucosal ulcer].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Apr;19(4):452-457
    Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
    An 8-year-old girl who had experienced intermittent cough and fever over a 3 year period, was admitted after experiencing a recurrence for one month. One year ago the patient experienced a recurrent oral mucosal ulcer. Physical examination showed vitiligo in the skin of the upper right back. Read More

    Severe Bone Marrow Suppression Accompanying Pulmonary Infection and Hemorrhage of the Digestive Tract Associated with Leflunomide and Low-dose Methotrexate Combination Therapy.
    J Pharmacol Pharmacother 2017 Jan-Mar;8(1):35-37
    Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
    A 60-year-old male patient developed hyperpyrexia, cough, expectoration with blood-stained sputum, mouth ulcers, and suppurative tonsillitis after receiving 35 days of combination treatment with leflunomide (LEF) and low-dose methotrexate (MTX) for active rheumatoid arthritis. On admission, routine blood tests showed severe thrombocytopenia, agranulocytosis, and decreased hemoglobin concentration compared with the relatively normal results of 1 month previously during the first hospitalization. Chest radiography revealed inflammation in both lungs, and a fecal occult blood test was positive. Read More

    Icons in paediatrics: Rolf Kostmann (1909-1982).
    Acta Paediatr 2017 Apr 12. Epub 2017 Apr 12.
    Department of Paediatrics, Linköping University, Vrinnevi Hospital, Norrköping, Sweden.
    In the medical literature, diseases and syndromes are sometimes named after the first person to publish a report on, or describe, a condition. This is, of course, a great honour, both for the physician and his or her country and only a handful of Swedish medical researchers have achieved this. Swedish paediatrician Rolf Kostmann (Fig. Read More

    BCL-2 as a therapeutic target in chronic lymphocytic leukemia.
    Clin Adv Hematol Oncol 2017 Mar;15(3):210-218
    Center for Chronic Lymphocytic Leukemia, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
    Venetoclax (formerly ABT-199) was recently approved in the United States for the treatment of patients who have relapsed or refractory chronic lymphocytic leukemia (CLL) with the 17p deletion. Venetoclax has demonstrated marked activity as monotherapy as well as in combination with cytotoxic chemotherapies, B-cell receptor inhibitors, and anti-CD20 monoclonal antibodies across the spectrum of CLL. The potency of venetoclax has been associated with a unique ability to induce deep (minimal residual disease-negative) complete remissions that appear to be durable. Read More

    Graves' disease in a 3 year-old patient with agranulocytosis due to anti-thyroid drugs: Radioiodine ablation therapy as an effective alternative.
    Rev Esp Med Nucl Imagen Mol 2017 Apr 6. Epub 2017 Apr 6.
    Unidad de Gestión Clínica de Medicina Nuclear, Hospital Regional Universitario de Málaga, Málaga, España.
    The case is presented of a 3 year-old girl with mitochondrial disease (subacute necrotizing encephalomyelopathy of Leigh syndrome), v-stage chronic kidney disease of a diffuse mesangial sclerosis, as well as developmental disorders, and diagnosed with hyperthyroidism Graves-Basedow disease. Six weeks after starting the treatment with neo-carbimazole, the patient reported a serious case of agranulocytosis. This led to stopping the anti-thyroid drugs, and was treated successfully with (131)I ablation therapy. Read More

    Agranulocytosis and mixed-type autoimmune hemolytic anemia in primary sjögren's syndrome: a case report and review of the literature.
    Int J Rheum Dis 2016 Dec 14;19(12):1351-1353. Epub 2015 Dec 14.
    Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease that presents with sicca symptoms of the main mucosal surfaces. Patients with pSS have a broad spectrum of laboratory features, such as cytopenias and hypergammaglobulinemia. Although hematological abnormalities are usually seen in pSS patients, agranulocytosis and autoimmune hemolytic anemia (AIHA) are rare. Read More

    A Case of Fatal Agranulocytosis That Developed in a Patient with β-Thalassemia Major Treated with Deferiprone.
    Hemoglobin 2016 Nov;40(6):435-437
    a Second Department of Internal Medicine , Aristotle University of Thessaloniki, General Hospital of Thessaloniki Hippokration , Thessaloniki , Greece.
    A 29-year-old male with transfusion-dependent β-thalassemia major (β-TM), splenectomized and on chelation therapy with deferiprone (DFP or L1) due to heart and liver hemosiderosis, presented with high fever and agranulocytosis. Deferiprone was discontinued and a broad spectrum antibiotic therapy was started intravenously. The patient remained febrile and showed no recovery of neutrophil count even after the initiation of granulocyte colony-stimulation factor (G-CSF). Read More

    Leukocytosis after Clozapine Treatment in a Patient with Chronic Schizophrenia.
    Noro Psikiyatr Ars 2016 Mar 1;53(1):87-88. Epub 2016 Mar 1.
    Department of Psychiatry, Kocaeli University School of Medicine, Kocaeli, Turkey.
    Clozapine is an atypical antipsychotic drug that is approved by the US Food and Drug Administration (FDA) for the treatment of psychotic disorders. Agranulocytosis is a well-established side effect of clozapine; clozapine has also been associated with other blood dyscrasias like leukocytosis, albeit rarely. In this paper, we aim to report a case of possible clozapine-associated leukocytosis in a 41-year-old woman. Read More

    Reticular dysgenesis: international survey on clinical presentation, transplantation and outcome.
    Blood 2017 Mar 22. Epub 2017 Mar 22.
    Biotherapy Clinical Investigation Center, Hopital Necker Enfants Malades, Paris, France.
    Reticular Dysgenesis (RD) is a rare congenital disorder defined clinically by the combination of severe combined immunodeficiency (SCID), agranulocytosis and sensorineural deafness. Mutations in the gene encoding Adenylate Kinase 2 (AK2) were identified to cause the disorder. Hematopoietic stem cell transplantation (HSCT) is the only option to cure this otherwise fatal disease. Read More

    Rescue pre-operative treatment with Lugol's solution in uncontrolled Graves' disease.
    Endocr Connect 2017 May 21;6(4):200-205. Epub 2017 Mar 21.
    Department of EndocrinologyMetabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
    Background: Graves' disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol's solution containing iodine/potassium iodide to induce euthyroidism before surgery could be advocated, but this has rarely been reported. Read More

    Dapsone-induced agranulocytosis-possible involvement of low-activity N-acetyltransferase 2.
    Fundam Clin Pharmacol 2017 Mar 21. Epub 2017 Mar 21.
    University of Zagreb School of Medicine, Šalata 3, 10 000, Zagreb, Croatia.
    Dapsone-induced agranulocytosis is a rare but potentially fatal adverse drug reaction (ADR). A 45-year-old male Caucasian patient developed agranulocytosis caused by dapsone (diamino-diphenyl sulfone), which he was prescribed for leukocytoclastic vasculitis. Patient's treatment consisted of termination of dapsone, antibiotic therapy, and granulocyte colony-stimulating factor leading to prompt improvement of symptoms and normalization of laboratory blood values. Read More

    Methimazole associated eosinophilic pleural effusion: a case report.
    BMC Pharmacol Toxicol 2017 Mar 21;18(1):16. Epub 2017 Mar 21.
    Serviço de Medicina 2, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Avenida Prof. Egas Moniz, 1649-035, Lisbon, Portugal.
    Background: Adverse reactions associated to anti-thyroid drugs include fever, rash, arthralgia, agranulocytosis and hepatitis that are thought to be hypersensitivity reactions. Five cases of pleural effusion associated to thionamides have also been reported, two with propylthiouracil and three with carbimazole.

    Case Presentation: We report here a case of a 75-year-old man admitted because of unilateral pleural effusion. Read More

    Multiple Drug Hypersensitivity.
    Int Arch Allergy Immunol 2017 Mar 18;172(3):129-138. Epub 2017 Mar 18.
    ADR-AC, Bern, Switzerland.
    Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS). Subsequent symptoms due to another drug often appear in the following weeks, overlapping with the first DHR, or months to years later after resolution of the initial presentation. Read More

    Adverse effects of levamisole in cocaine users: a review and risk assessment.
    Arch Toxicol 2017 Mar 17. Epub 2017 Mar 17.
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands.
    The immunomodulatory adjuvant and antihelminth levamisole is increasingly used as an adulterant in cocaine worldwide. An accumulating body of clinical and toxicological literature has appeared since 2010 describing neutropenia, agranulocytosis, leukoencephalopathy and vasculitis in cases associated with levamisole-adulterated cocaine. Mostly, neutropenia and agranulocytosis were reported, characterized by a decimation of neutrophils. Read More

    Multicenter Phase II Clinical Trial of Genexol-PM® with Gemcitabine in Advanced Biliary Tract Cancer.
    Anticancer Res 2017 03;37(3):1467-1473
    Division of Hematology/Oncology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea
    This multicenter phase II clinical trial was designed to evaluate the efficacy and safety of weekly Genexol-PM® and gemcitabine combination chemotherapy in patients with unresectable or metastatic biliary tract cancer.

    Patients And Methods: Patients received 100 mg/m(2) Genexol-PM® and 1,000 mg/m(2) gemcitabine intravenously on days 1 and 8 every 21 days.

    Results: Out of 39 patients, there were 10 partial responses (25. Read More

    [Evaluation of hemogram in patients with homozygous sickle cell disease: about 87 cases].
    Pan Afr Med J 2016 20;25:240. Epub 2016 Dec 20.
    Équipe de Recherche en Hématologie, Laboratoire d'Hématologie, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc; Laboratoire Central d'Hématologie, Centre Hospitalier Ibn Sina, Rabat, Maroc.
    Homozygous sickle cell disease is one of the most frequent haemoglobinopathies in Morocco. Sickle cell disease is characterized by a large clinical and biological expression variability which depends on modulating genetic and environmental factors. Clinical manifestation includes regenerative anemia whose severity may vary among individuals. Read More

    Potential Mechanisms of Hematological Adverse Drug Reactions in Patients Receiving Clozapine in Combination With Proton Pump Inhibitors.
    J Psychiatr Pract 2017 Mar;23(2):114-120
    WICIŃSKI, WĘCLEWICZ, MIĘTKIEWICZ, MALINOWSKI, and GRZEŚK: Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Bydgoszcz, Poland KLONOWSKA: College of Engineering and Health, Warsaw, Poland.
    Clozapine is a second-generation antipsychotic which has proven efficacy in treating the symptoms of schizophrenia. Although clozapine therapy is associated with a number of adverse drug reactions, it is frequently used. One of the most common adverse drug reactions is gastroesophageal reflux disease which is an indication for treatment with proton pump inhibitors (PPIs). Read More

    Chronic use of metamizole: not so safe after all?
    Neth J Med 2017 Mar;75(2):81-83
    Department of Gastroenetrology, Jeroen Bosch Hospital, Den Bosch, the Netherlands.
    Metamizole can be used in both short- and long-term pain relief therapies and has a relatively favourable safety profile compared with classic NSAIDs. Metamizole is also infamous because of its potential fatal adverse drug reaction, agranulocytosis. Although this risk varies, it is estimated to occur in less than one million metamizole prescriptions. Read More

    Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors.
    Respir Investig 2017 Mar 12;55(2):181-183. Epub 2017 Jan 12.
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
    A 59-year-old woman with epidermal growth factor receptor gene (EGFR) mutation-positive advanced lung adenocarcinoma was treated with afatinib after a diagnosis of chronic myelomonocytic leukemia (CMML). Twenty-one weeks later, she developed agranulocytosis, and CMML subsequently progressed to blast crisis. After complete remission of CMML, gefitinib was initiated; however, agranulocytosis recurred. Read More

    [Leukopenia with unclear fever].
    Internist (Berl) 2017 Mar 6. Epub 2017 Mar 6.
    Medizinische Klinik, Sana Krankenhaus Gerresheim, Sana Kliniken Düsseldorf GmbH, Gräulinger Str. 120, 40625, Düsseldorf, Deutschland.
    We report on a 77-year-old male patient with neutropenic fever as a result of a newly diagnosed agranulocytosis. The patient was taking metamizole, which is a well known cause of agranulocytosis. The diagnosis of metamizole-induced agranulocytosis as an underestimated side-effect of metamizole could be confirmed by a bone marrow biopsy. Read More

    Successful clozapine re-challenge in a patient with three previous episodes of clozapine-associated blood dyscrasia.
    BJPsych Open 2017 Jan 9;3(1):22-25. Epub 2017 Feb 9.
    , BSc MBBS SFHEA PhD FRCPsych, National Psychosis Unit, South London and Maudsley NHS Foundation Trust, London, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
    A case is presented of a 30-year-old female with treatment-resistant schizoaffective disorder who was referred to a tertiary-level specialist psychosis service. We describe the history of clozapine trials and associated episodes of agranulocytosis and neutropenia, followed by the successfully tolerated third clozapine re-challenge within our service.

    Declaration Of Interest: None. Read More

    Emphasis on the early diagnosis of antithyroid drug-induced agranulocytosis: retrospective analysis over 16 years at one Chinese center.
    J Endocrinol Invest 2017 Feb 24. Epub 2017 Feb 24.
    Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, 710061, Shaanxi, People's Republic of China.
    Purpose: Antithyroid drug (ATD)-induced agranulocytosis is a rare but life-threatening adverse drug reaction that occurs in patients during the treatment of Graves' disease. We aimed to comprehensively examine data for patients with this rare complication and to improve the clinical safety of ATDs.

    Methods: We retrospectively reviewed the medical records of 64 hospitalized patients diagnosed with ATD-induced agranulocytosis between 2000 and 2015. Read More

    Aplastic Anemia and Severe Myelosuppression with Boceprevir or Simeprevir-Containing Hepatitis C Virus Treatment.
    Ann Hepatol 2017 March-April;16(2):312-317
    Liver Unit, Gastroenterology Department, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
    The addition of the new protease inhibitors (PIs) to peg-interferon (IFN) and ribavirin (RBV), approved for chronic hepatitis C, has clearly improved sustained virological response (SVR) rates although several adverse events have been reported with this regimens, including mild hematological toxicity. Moreover, severe pancytopenia and aplastic anemia during triple therapy with telaprevir has recently been described in seven patients. We report here two cases of severe agranulocytosis/aplastic anemia using boceprevir or simeprevir in interferon-based combination and 2 additional cases of severe myelosupression in IFN-free therapy with sofosbuvir and simeprevir plus RBV. Read More

    Clinical Development of Histamine H4 Receptor Antagonists.
    Handb Exp Pharmacol 2017 Feb 24. Epub 2017 Feb 24.
    Janssen Research & Development, LLC, San Diego, CA, 92121, USA.
    The discovery of the histamine H4 receptor (H4R) provided a new avenue for the exploration of the physiological role of histamine, as well as providing a new drug target for the development of novel antihistamines. The first step in this process was the identification of selective antagonists to help unravel the pharmacology of the H4R relative to other histamine receptors. The discovery of the selective H4R antagonist JNJ 7777120 was vital for showing a role for the H4R in inflammation and pruritus. Read More

    Asymmetric dimethylarginine in the assessment of febrile neutropenia in hematological patients.
    Scand J Clin Lab Invest 2017 Apr;77(2):130-134
    b Department of Medicine , Kuopio University Hospital , Kuopio , Finland.
    Asymmetric dimethylarginine (ADMA) has been recognized as an independent prognostic factor for sepsis mortality in intensive care units. No data are available on kinetics or prognostic value of ADMA in hematological patients. We evaluated the ability of ADMA to act as a predictor for complicated course of febrile neutropenia, defined as bacteremia and/or septic shock in adult hematological patients receiving intensive chemotherapy. Read More

    Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case.
    J Clin Diagn Res 2016 Dec 1;10(12):FD01-FD03. Epub 2016 Dec 1.
    Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
    Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count. Read More

    [Pathogens of infections in the induction period of childhood acute lymphoblastic leukemia and drug resistance of isolated strains].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Feb;19(2):176-181
    Fujian Institute of Hematology/Fujian Key Laboratory on Hematology/Fujian Medical University Union Hospital, Fuzhou 350001, China.
    Objective: To investigate the infections occurring in the induction period of childhood acute lymphoblastic leukemia (ALL), the pathogens of the infections, and drug resistance of isolated strains.

    Methods: A retrospective analysis was performed for the clinical data of 130 children with newly-diagnosed childhood ALL. Infections occurring during the induction chemotherapy, pathogenic strains, and drug-resistance spectrum were analyzed. Read More

    Hematologic manifestations of babesiosis.
    Ann Clin Microbiol Antimicrob 2017 Feb 15;16(1). Epub 2017 Feb 15.
    Department of Infectious Diseases, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY, 10305, USA.
    Background: Babesiosis, a zoonotic parasitic infection transmitted by the Ixodes tick, has become an emerging health problem in humans that is attracting attention worldwide. Most cases of human babesiosis are reported in the United States and Europe. The disease is caused by the protozoa of the genus Babesia, which invade human erythrocytes and lyse them causing a febrile hemolytic anemia. Read More

    Clinical Outcomes of Hypopharyngeal Cancer Receiving Definitive Radiotherapy with Concurrent Chemotherapy.
    Anticancer Res 2017 02;37(2):941-947
    Sonodakai Radiation Oncology Clinic, Tokyo, Japan.
    Aim: To evaluate clinical outcomes of concurrent chemoradiotherapy (CCRT) in patients with hypopharyngeal cancer (HPC).

    Patients And Methods: This retrospective study included 80 patients (75 males) aged 48 to 78 years (median=66 years) with a histological diagnosis of HPC. The 5-fluorouracil and cisplatin (FP) regimen was used until 2007 and then switched to the docetaxel, cisplatin, and 5-fluorouracil (TPF) regimen. Read More

    Carboplatin plus Weekly Paclitaxel Combined with Bevacizumab as First-line Treatment for Non-small Cell Lung Cancer.
    Anticancer Res 2017 02;37(2):923-928
    Department of Respiratory Medicine, Mihara Red Cross Hospital, Mihara, Japan.
    Aim: We aimed to evaluate the efficacy and safety of carboplatin plus weekly paclitaxel with bevacizumab in patients with advanced non-squamous non-small cell lung cancer (NSCLC).

    Patients And Methods: Patients with stage IIIB/IV or postoperative recurrent NSCLC (n=33) were treated with carboplatin (area under the curve of 6) on day 1; paclitaxel (80 mg/m(2)) on days 1, 8, and 15; and bevacizumab (15 mg/kg) on day 1 repeated every 4 weeks, for four to six cycles; followed by maintenance bevacizumab (15 mg/kg) every 3 weeks.

    Results: The overall response rate was 76%. Read More

    A Multicenter Phase II Study of Gemcitabine plus S-1 Chemotherapy for Advanced Biliary Tract Cancer.
    Anticancer Res 2017 02;37(2):909-914
    Department of Medical Oncology, Kyorin University Faculty of Medicine, Tokyo, Japan
    Background: Gemcitabine (GEM) plus cisplatin (CDDP) chemotherapy has been used worldwide as the standard first-line treatment for advanced biliary tract cancer (BTC). A phase II trial has also suggested promising activity of GEM plus S-1 chemotherapy against advanced BTC. The aim of this study was to evaluate the efficacy and safety of GEM plus S-1 chemotherapy in patients with advanced BTC. Read More

    Phase I Study of Nab-Paclitaxel plus Gemcitabine as Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer.
    Anticancer Res 2017 02;37(2):853-858
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    Background/aim: The aim of this study was to investigate the safety and feasibility of neoadjuvant nab-paclitaxel plus gemcitabine therapy for patients with borderline resectable pancreatic carcinoma (BRPC).

    Patients And Methods: The study was a prospective single-center phase I trial for patients with BRPC. The primary endpoint was the toxicity, and secondary endpoints were the resection rate, the R0 resection rate and quality of life (QOL) regarding the peripheral sensory neuropathy (PSN). Read More

    Efficacy and Toxicity of Induction Therapy with Cladribine, Idarubicin, and Cytarabine (IAC) for Acute Myeloid Leukemia.
    Anticancer Res 2017 02;37(2):713-717
    Saint Louis University School of Medicine, Saint Louis, MO, U.S.A.
    We report our single-center experience with cytarabine and idarubicin for induction therapy for acute myeloid leukemia (AML) with an additional 5 days of cladribine (IAC therapy). From July 2012 to September 2014, 38 patients completed a full course of IAC induction. Median patient age was 61 years, 61% of patients were ≥60 years old, and 71% were male. Read More

    Characterization of Admission Types in Medically Hospitalized Patients Prescribed Clozapine.
    Psychosomatics 2017 Mar - Apr;58(2):164-172. Epub 2016 Nov 18.
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
    Background: Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia; however, rigorous monitoring is required to prevent or detect adverse drug events that contribute to morbidity and mortality. In addition to the Food and Drug Administration (FDA) boxed safety warnings specific to clozapine (agranulocytosis, hypotension, seizures, and cardiomyopathy/myocarditis), other adverse events such as pneumonia and gastrointestinal hypomotility have been reported in the literature to result in hospitalization.

    Objective: To explore the reasons for medical hospitalization in patients prescribed clozapine, a retrospective chart review was completed. Read More

    Biocompatible biodegradable polymeric antibacterial nanoparticles for enhancing the effects of a third-generation cephalosporin against resistant bacteria.
    J Med Microbiol 2017 Mar 23;66(3):318-327. Epub 2017 Mar 23.
    1​Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
    Purpose: In the present study, enhancement of the the antibacterial activity of ceftriaxone against Gram-positive (meticillin-resistant Staphylococcus aureus; MRSA) and Gram-negative (Escherichia coli) bacteria with a biodegradable polymer was attempted.

    Methodology: MRSA and E. coli were collected and identified by biochemical and molecular tests. Read More

    Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry.
    Mycoses 2017 Apr 2;60(4):273-279. Epub 2017 Feb 2.
    Division of Infectious Diseases, Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
    Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare IFD from the FungiScope(™) registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12-year period. Read More

    The efficacy of trabectedin in treating ovarian cancer.
    Expert Opin Pharmacother 2017 Feb;18(3):313-323
    b Paul & Carolyn Flory Endowed Professor , University of Cincinnati Cancer Institute , Cincinnati , OH , USA.
    Introduction: The majority of women with epithelial ovarian cancer present with advanced stage disease and there is a critical need for novel drugs and treatment strategies to improve outcomes. Trabectedin is a unique cytotoxic agent with a complex mechanism of action. It binds to guanines in the N2 position in the minor groove of DNA and its cytotoxicity involves DNA repair pathways and transcription regulation. Read More

    Clozapine and long-acting injectable antipsychotic combination: A retrospective one-year mirror-image study.
    Schizophr Res 2017 Jan 27. Epub 2017 Jan 27.
    Department of Psychiatry, Service Hospitalo-Universitaire, Centre Hospitalier Sainte-Anne, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Paris, France; INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S894, Paris, France.
    To evaluate efficacy and tolerability of the combination of clozapine with an antipsychotic long-acting injectable (LAI) in multi-episode patients with schizophrenia or schizoaffective disorder. Efficacy and tolerability were assessed in seventeen patients admitted to a hospital in Paris between January 2010 and June 2015, using a one-year mirror-image design. Number and length of hospitalizations significantly decreased after introducing the combination (2. Read More

    ANCA Associated Vasculitis Secondary to Levamisole-Adultered Cocaine with Associated Membranous Nephropathy: A Case Series.
    Am J Nephrol 2017 28;45(3):209-216. Epub 2017 Jan 28.
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada.
    Background: Cocaine is a risk factor for acute kidney injury and chronic kidney disease with progression to end-stage renal disease. Levamisole is an adulterant that is added to cocaine to enhance its euphoric effects. Levamisole-adulterated cocaine (LAC) is associated with the distinct clinical syndromes of agranulocytosis, leukocytoclastic vasculitis, cocaine-induced midline destructive lesions (CIMDL), and ANCA-associated vasculitis (AAV) with pauci-immune necrotizing glomerulonephritis. Read More

    The effect of mirtazapine on dopaminergic psychosis and dyskinesia in the parkinsonian marmoset.
    Psychopharmacology (Berl) 2017 Mar 27;234(6):905-911. Epub 2017 Jan 27.
    Centre de Recherche du Centre Hospitalier de l'Université de Montréal, R09.436, 900 Rue St-Denis, Montreal, QC, H2X 0A9, Canada.
    Background: Parkinson's disease (PD) psychosis is encountered in as many as 50% of patients with advanced disease. Treatment options for PD psychosis are few. In fact, only clozapine and pimavanserin have shown efficacy in randomised controlled trials. Read More

    Safety, efficacy and pharmacokinetics of humanized anti-CD52 monoclonal antibody alemtuzumab in Japanese patients with relapsed or refractory B-cell chronic lymphocytic leukemia.
    Jpn J Clin Oncol 2017 Jan 7;47(1):54-60. Epub 2016 Oct 7.
    Department of Hematology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.
    Objective: To evaluate the safety, efficacy and pharmacokinetics of alemtuzumab in Japanese patients, we conducted a phase I study in patients with relapsed or refractory B-cell chronic lymphocytic leukemia.

    Methods: Six patients received alemtuzumab by intravenous infusion every other day three times a week for 12 weeks. The dose was gradually escalated on daily basis (3, 10 and then 30 mg) until the patient tolerated. Read More

    Efficacy of reduced dose of pegfilgrastim in Japanese breast cancer patients receiving dose-dense doxorubicin and cyclophosphamide therapy.
    Jpn J Clin Oncol 2017 Jan 7;47(1):12-17. Epub 2016 Oct 7.
    Department of Breast Oncology, Tokyo-West Tokushukai Hospital, Akishima, Tokyo 196-0003.
    Background: This retrospective study aimed to evaluate the efficacy of a 3.6-mg dose of pegfilgrastim for primary prophylaxis in Japanese breast cancer patients receiving dose-dense chemotherapy.

    Methods: Patients treated with adjuvant or neoadjuvant chemotherapy for early-stage breast cancer at the Tokyo-West Tokushukai Hospital were included in this analysis. Read More

    Associations of Antifungal Treatments With Prevention of Fungal Infection in Critically Ill Patients Without Neutropenia.
    JAMA 2017 01;317(3):311-312
    Department of Biopathology and Medical Biotechnologies, Section of Anesthesia Analgesia Intensive Care and Emergency, University of Palermo, Palermo, Italy.
    Clinical Question: Are antifungal agents associated with lower rates of mortality and invasive fungal infections when administered before definitive diagnosis of an invasive fungal infection in critically ill patients without neutropenia?

    Bottom Line: Antifungal treatment administered prior to diagnosis of an invasive fungal infection is not associated with either higher or lower rates of all-cause mortality. Antifungal treatment in this setting is associated with lower rates of invasive fungal infections compared with placebo or no intervention in critically ill patients without neutropenia, but the quality of the evidence is low. Read More

    COKE LIVe: recurrent vasculitis secondary to cocaine contaminated with levamisole.
    Acute Med 2016 ;15(4):206-208
    Levamisole-induced vasculitis (LIV) is becoming an increasingly common entity secondary to both rising cocaine use in the UK and high levels of adulteration of cocaine with various contaminants. We report the first documented case of LIV secondary to adulterated cocaine in Ireland, which presented as a 6-year history of recurrent vasculitis of unknown aetiology. Classically, LIV is diagnosed by a combination of positive ANCA serology and agranulocytosis however, given the frequency of cocaine use, we urge acute physicians to consider the diagnosis in cases of typical retiform (angulated) purpura in association with a history of cocaine use. Read More

    Clinical and microbiological characteristics of bloodstream infections among patients with haematological malignancies with and without neutropenia at a medical centre in northern Taiwan, 2008-2013.
    Int J Antimicrob Agents 2017 Mar 3;49(3):272-281. Epub 2017 Jan 3.
    Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
    This study aimed to investigate the epidemiology and microbiology of bloodstream infections (BSIs) in patients with haematological malignancies. Clinical characteristics and microbiology of 2083 patients with haematological malignancy who were treated for BSI from 2008 to 2013 at a medical centre in Taiwan were retrospectively reviewed. Lymphoma (38. Read More

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