477 results match your criteria Aging and disease[Journal]


Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging.

Aging Dis 2019 Feb 1;10(1):197-204. Epub 2019 Feb 1.

1Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, Australia.

The cell proliferation marker, Ki67 and the immature neuron marker, doublecortin are both expressed in the major human neurogenic niche, the subependymal zone (SEZ), but expression progressively decreases across the adult lifespan (PMID: 27932973). In contrast, transcript levels of several mitogens (transforming growth factor α, epidermal growth factor and fibroblast growth factor 2) do not decline with age in the human SEZ, suggesting that other growth factors may contribute to the reduced neurogenic potential. While insulin like growth factor 1 (IGF1) regulates neurogenesis throughout aging in the mouse brain, the extent to which IGF1 and IGF family members change with age and relate to adult neurogenesis markers in the human SEZ has not yet been determined. Read More

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http://dx.doi.org/10.14336/AD.2018.0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345338PMC
February 2019

Relationship between Hypothyroidism and Endometrial Cancer.

Aging Dis 2019 Feb 1;10(1):190-196. Epub 2019 Feb 1.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Thyroid dysfunction is involved in several types of carcinoma. Hypothyroidism is one of the most common medical morbidities among patients with endometrial cancer; however, the related mechanism is unclear. Among the risk factors related to endometrial cancer, hypothyroidism interacts with metabolic syndrome, polycystic ovarian syndrome and infertility or directly acts on the endometrium itself, which may influence the development and progression of endometrial cancer. Read More

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http://dx.doi.org/10.14336/AD.2018.0224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345335PMC
February 2019
7 Reads

Epigenetic Regulation of Bone Marrow Stem Cell Aging: Revealing Epigenetic Signatures associated with Hematopoietic and Mesenchymal Stem Cell Aging.

Aging Dis 2019 Feb 1;10(1):174-189. Epub 2019 Feb 1.

1Mesenchymal Stem Cell Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.

In this review we explore the importance of epigenetics as a contributing factor for aging adult stem cells. We summarize the latest findings of epigenetic factors deregulated as adult stem cells age and the consequence on stem cell self-renewal and differentiation, with a focus on adult stem cells in the bone marrow. With the latest whole genome bisulphite sequencing and chromatin immunoprecipitations we are able to decipher an emerging pattern common for adult stem cells in the bone marrow niche and how this might correlate to epigenetic enzymes deregulated during aging. Read More

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http://dx.doi.org/10.14336/AD.2017.1213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345334PMC
February 2019

Prospective Views for Whey Protein and/or Resistance Training Against Age-related Sarcopenia.

Aging Dis 2019 Feb 1;10(1):157-173. Epub 2019 Feb 1.

1Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Skeletal muscle aging is characterized by decline in skeletal muscle mass and function along with growing age, which consequently leads to age-related sarcopenia, if without any preventive timely treatment. Moreover, age-related sarcopenia in elder people would contribute to falls and fractures, disability, poor quality of life, increased use of hospital services and even mortality. Whey protein (WP) and/or resistance training (RT) has shown promise in preventing and treating age-related sarcopenia. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0325
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http://dx.doi.org/10.14336/AD.2018.0325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345331PMC
February 2019
9 Reads

Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or ?

Aging Dis 2019 Feb 1;10(1):147-156. Epub 2019 Feb 1.

4Department of Exercise Science, Chatham University, Pittsburgh, PA 15232, USA.

Age-associated hyper-inflammation or "inflamm-aging" has been linked to the development of chronic diseases and characterized as an unavoidable aspect of aging. However, the inflamm-aging model does not adequately address the potential anti-inflammatory effects of exercise training and the potential for exercise to ameliorate several age-related diseases. In this brief review, we introduce a new paradigm--that describes a potent counter-measure to age-associated inflammatory illness. Read More

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http://dx.doi.org/10.14336/AD.2018.0326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345337PMC
February 2019

Rosenroot (): Potential Applications in Aging-related Diseases.

Aging Dis 2019 Feb 1;10(1):134-146. Epub 2019 Feb 1.

5Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.

Aging is a progressive accumulation of changes in the body, which increases the susceptibility to diseases such as Alzheimer's disease, Parkinson's disease, cerebrovascular disease, diabetes, and cardiovascular disease. Recently, Chinese medicinal herbs have been investigated for their therapeutic efficacy in the treatment of some aging-related diseases. , known as 'Hongjingtian' in Chinese, has been reported to have anti-aging activity. Read More

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http://dx.doi.org/10.14336/AD.2018.0511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345333PMC
February 2019
2 Reads

Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury.

Aging Dis 2019 Feb 1;10(1):116-133. Epub 2019 Feb 1.

1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Aging may aggravate the damage and dysfunction of different components of multiorgan and thus increasing multiorgan ischemia/reperfusion (IR) injury. IR injury occurs in many organs and tissues, which is a major cause of morbidity and mortality worldwide. The kinase mammalian target of rapamycin (mTOR), an atypical serine/threonine protein kinase, involves in the pathophysiological process of IR injury. Read More

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http://dx.doi.org/10.14336/AD.2018.0501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345330PMC
February 2019

-mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy.

Aging Dis 2019 Feb 1;10(1):102-115. Epub 2019 Feb 1.

1Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun 130062, China.

Premature aging syndromes are rare genetic disorders mimicking clinical and molecular features of aging. Products of the gene, primarily lamin A and C, are major components of the nuclear lamina. A recently identified group of premature aging syndromes was related to mutations of the gene. Read More

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http://dx.doi.org/10.14336/AD.2018.0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345340PMC
February 2019
2 Reads

rs3796529 Genotype and Rate of Functional Deterioration in Alzheimer's Disease.

Aging Dis 2019 Feb 1;10(1):94-101. Epub 2019 Feb 1.

2Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Recently, (RE1-silencing transcription factor) gene has been shown to be lost in Alzheimer's disease (AD), and a missense minor allele rs3796529-T has been shown to reduce the rate of hippocampal volume loss. However, whether the rs3796529 genotype is associated with the rate of functional deterioration in AD is unknown. A total of 584 blood samples from Taiwanese patients with AD were collected from January 2002 to December 2013. Read More

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http://dx.doi.org/10.14336/AD.2018.0116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345341PMC
February 2019

DRAM is Involved in Hypoxia/Ischemia-Induced Autophagic Apoptosis in Hepatocytes.

Aging Dis 2019 Feb 1;10(1):82-93. Epub 2019 Feb 1.

1Beijing You'an Hospital Affiliated with Capital Medical University, Beijing 100069, China.

Liver hypoxia/ischemia injury leads to acute liver injury, delayed graft dysfunction, and failure during liver transplantation. Previous studies showed that autophagy is involved in liver hypoxia/ischemia injury. Our and others' studies have found that the damage-regulated autophagy modulator (DRAM) could induce the autophagic apoptosis. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0210
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http://dx.doi.org/10.14336/AD.2018.0210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345327PMC
February 2019
2 Reads

Chronic Kidney Disease Is Linked to Carotid Nodular Calcification, An Unstable Plaque Not Correlated to Inflammation.

Aging Dis 2019 Feb 1;10(1):71-81. Epub 2019 Feb 1.

5Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Italy.

The incidence and the different type of carotid calcifications, nodular and non-nodular, and their role in the acute cerebrovascular disease has not yet been defined. Various studies have correlated the presence of specific risk factors, in particular the chronic kidney disease, with the presence of calcification, but not with the type of calcification. Since it is likely that carotid nodular calcifications rather than those with non-nodular aspect may represent a plaque at high risk of rupture, the purpose of our study was to evaluate the role of nodular calcification in the pathogenesis of cerebrovascular syndromes and their possible correlation with specific risk factors. Read More

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http://dx.doi.org/10.14336/AD.2018.0117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345328PMC
February 2019

Distribution Pattern of Atherosclerotic Stenosis in Chinese Patients with Stroke: A Multicenter Registry Study.

Aging Dis 2019 Feb 1;10(1):62-70. Epub 2019 Feb 1.

20Department of Ultrasonography, Brain Hospital of Hunan Province, China.

The aim of this multicenter study was to demonstrate the distribution pattern of atherosclerotic stenosis and its trend with aging between extracranial and intracranial arteries and its distribution between the anterior and posterior circulations in Chinese patients hospitalized with ischemic stroke. In addition, the risk factors for the distribution pattern were illustrated. From June 2015 to May 2016, 9,346 patients with ischemic stroke from 20 hospitals were enrolled. Read More

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http://dx.doi.org/10.14336/AD.2018.0602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345329PMC
February 2019
1 Read

Aging and End Stage Renal Disease Cause A Decrease in Absolute Circulating Lymphocyte Counts with A Shift to A Memory Profile and Diverge in Treg Population.

Aging Dis 2019 Feb 1;10(1):49-61. Epub 2019 Feb 1.

2Renal Transplant Service, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.

There is a growing number of elderly kidney transplant (Ktx) recipients. Elderly recipients present lower acute rejection rates but higher incidence of infection and malignancies. Aging seems to result in a shift to memory profile and chronic kidney disease (CKD) in premature immunological aging. Read More

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http://dx.doi.org/10.14336/AD.2018.0318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345336PMC
February 2019
2 Reads

Metformin and the Risk of Dementia in Type 2 Diabetes Patients.

Authors:
Tseng Chin-Hsiao

Aging Dis 2019 Feb 1;10(1):37-48. Epub 2019 Feb 1.

1Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

This retrospective cohort study investigated dementia risk associated with metformin use in type 2 diabetes patients by using the reimbursement database of the Taiwan's National Health Insurance. The patients had new-onset diabetes during 1999-2005 and were followed up until December 31, 2011. An unmatched cohort of 147,729 ever users and 15,676 never users of metformin were identified, and a matched-pair cohort of 15,676 ever users and 15,676 never users was created by propensity score (PS). Read More

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http://dx.doi.org/10.14336/AD.2017.1202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345339PMC
February 2019

Quantitative Evaluation of Gait Disturbance on an Instrumented Timed Up-and-go Test.

Aging Dis 2019 Feb 1;10(1):23-36. Epub 2019 Feb 1.

1Normal Pressure Hydrocephalus Center, Rakuwakai Otowa Hospital, Rakuwakai Healthcare System, Kyoto, Japan.

Although the 3-m timed up-and-go test (TUG) is reliable for evaluating mobility, TUG time is insufficient to evaluate mild gait disturbance; we, therefore aimed to investigate other measurements with instrumented TUG (iTUG) using a free smartphone application. Our inclusion criterion in this study is only that participants can walk without any assistance. This study included three heterogeneous groups; patients who underwent a tap test or shunt surgery, 29 inpatients hospitalized for other reasons, and 87 day-care users. Read More

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http://dx.doi.org/10.14336/AD.2018.0426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345343PMC
February 2019
1 Read

Increased Inflammatory Response in Old Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke.

Aging Dis 2019 Feb 1;10(1):12-22. Epub 2019 Feb 1.

2Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.

Stroke occurs mostly in patients with advanced age. Elderly patients have a less favorable prognosis compared with young adult patients. To understand the underlying mechanisms, we tested our hypothesis that an increased inflammatory response to acute ischemic injury in old stroke mice leads to more severe brain damage and behavioral dysfunction. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0205
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http://dx.doi.org/10.14336/AD.2018.0205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345332PMC
February 2019
4 Reads

Is Dementia More Fatal Than Previously Estimated? A Population-based Prospective Cohort Study.

Aging Dis 2019 Feb 1;10(1):1-11. Epub 2019 Feb 1.

1Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.

Dementia increases the risk of mortality (ROM) in the elderly and estimates of hazard ratio (HR) of dementia for mortality have ranged from 1.7 to 6.3. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0123
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http://dx.doi.org/10.14336/AD.2018.0123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345342PMC
February 2019
10 Reads

Emerging Anti-Aging Strategies - Scientific Basis and Efficacy.

Aging Dis 2018 Dec 4;9(6):1165-1184. Epub 2018 Dec 4.

1Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center College of Medicine, College Station, Texas 77843, USA.

The prevalence of age-related diseases is in an upward trend due to increased life expectancy in humans. Age-related conditions are among the leading causes of morbidity and death worldwide currently. Therefore, there is an urgent need to find apt interventions that slow down aging and reduce or postpone the incidence of debilitating age-related diseases. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.1026
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http://dx.doi.org/10.14336/AD.2018.1026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284760PMC
December 2018
9 Reads

Therapeutic Potential and Effective Components of the Chinese Herb Gardeniae Fructus in the Treatment of Senile Disease.

Aging Dis 2018 Dec 4;9(6):1153-1164. Epub 2018 Dec 4.

1Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing, China.

Gardeniae fructus (GF), an evergreen Rubiaceae shrub, is one of the most commonly used Chinese herbs in traditional Chinese medicine (TCM) and has been used for over a thousand years. It is usually prescribed for the treatment of brain aging, vascular aging, bone and joint aging, and other age-related diseases. It has been demonstrated that several effective compounds of GF, such as geniposide, genipin and crocin, have neuroprotective or related activities which are involved in senile disease treatment. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0112
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http://dx.doi.org/10.14336/AD.2018.0112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284761PMC
December 2018
1 Read

Molecular Bases of Alzheimer's Disease and Neurodegeneration: The Role of Neuroglia.

Aging Dis 2018 Dec 4;9(6):1134-1152. Epub 2018 Dec 4.

2Department of General Surgery and Medical-Surgical Specialties, Dermatology Clinic, University Hospital Policlinico-Vittorio Emanuele, Catania, 95100 Sicily, Italy.

Neuroglia is an umbrella term indicating different cellular types that play a pivotal role in the brain, being involved in its development and functional homeostasis. Glial cells are becoming the focus of recent researches pertaining the pathogenesis of neurodegenerative disorders, Alzheimer's Disease (AD) in particular. In fact, activated microglia is the main determinant of neuroinflammation, contributing to neurodegeneration. Read More

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http://dx.doi.org/10.14336/AD.2018.0201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284765PMC
December 2018

Remote Ischemic Conditioning Protects Diabetic Retinopathy in Streptozotocin-induced Diabetic Rats via Anti-Inflammation and Antioxidation.

Aging Dis 2018 Dec 4;9(6):1122-1133. Epub 2018 Dec 4.

1Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Beijing, China.

Ischemic conditioning inhibits oxidative stress and inflammatory response in diabetes. However, whether limb remote ischemic conditioning (LRIC) has beneficial effects on diabetic retinopathy (DR) remains unknown. This study aims to investigate the protective effects of LRIC in retinal ganglion cell in streptozotocin (STZ) induced Type 1 diabetic rats. Read More

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http://dx.doi.org/10.14336/AD.2018.0711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284762PMC
December 2018

MiR-1292 Targets FZD4 to Regulate Senescence and Osteogenic Differentiation of Stem Cells in TE/SJ/Mesenchymal Tissue System via the Wnt/β-catenin Pathway.

Aging Dis 2018 Dec 4;9(6):1103-1121. Epub 2018 Dec 4.

1Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Center of Excellence in Tissue Engineering Chinese Academy of Medical Sciences, Beijing Key Laboratory (No. BZO381), Beijing, China.

With the expansion of the elderly population, age-related osteoporosis and the resulting bone loss have become a significant health and socioeconomic issue. In Triple Energizer (TE)/San Jiao (SJ)/mesenchymal tissue system, mesenchymal stem cell (MSC) senescence, and impaired osteogenesis are thought to contribute to age-related diseases such as osteoporosis. Therefore, comprehending the molecular mechanisms underlying MSC senescence and osteogenesis is essential to improve the treatment of bone metabolic diseases. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.1110
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http://dx.doi.org/10.14336/AD.2018.1110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284756PMC
December 2018
1 Read

Intracranial Atherosclerosis Burden and Stroke Recurrence for Symptomatic Intracranial Artery Stenosis (sICAS).

Aging Dis 2018 Dec 4;9(6):1096-1102. Epub 2018 Dec 4.

Intracranial atherosclerosis burden is an arising key index for the risk and prognosis for Intracranial Atherosclerosis Stenosis (ICAS). The present study estimated one-year prognosis for patients of symptomatic ICAS with different degrees of intracranial atherosclerosis burden (ICASB) and identified whether the category of multiple and single acute infarction was associated with atherosclerosis burden. A total of 2864 consecutive patients, from 22 hospitals across China, who experienced an acute cerebral ischemia <7 days after onset of symptoms were evaluated. Read More

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http://dx.doi.org/10.14336/AD.2018.0301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284755PMC
December 2018

Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease.

Aging Dis 2018 Dec 4;9(6):1084-1095. Epub 2018 Dec 4.

1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.

Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin' Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 healthy controls were consecutively recruited. Olfactory function was evaluated by self-report, HRS and Sniffin' Sticks test. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0819
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http://dx.doi.org/10.14336/AD.2018.0819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284764PMC
December 2018
13 Reads

Association between Leukoaraiosis and Symptomatic Intracranial Large Artery Stenoses and Occlusions: the Chinese Intracranial Atherosclerosis (CICAS) Study.

Aging Dis 2018 Dec 4;9(6):1074-1083. Epub 2018 Dec 4.

1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Leukoaraiosis (LA) is frequently found in ischemic stroke patients, especially when those patients have intracranial atherosclerosis (ICAS). However, previous studies regarding an association of LA with cerebral large artery atherosclerosis showed conflicting results, and the relationship of LA with ICAS is uncertain. This study aimed to explore the association between LA and cerebral large artery atherosclerosis in Chinese patients with cerebral ischemia. Read More

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http://dx.doi.org/10.14336/AD.2018.0118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284759PMC
December 2018
4 Reads

MiRNA-10b Reciprocally Stimulates Osteogenesis and Inhibits Adipogenesis Partly through the TGF-β/SMAD2 Signaling Pathway.

Aging Dis 2018 Dec 4;9(6):1058-1073. Epub 2018 Dec 4.

1Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Center of Excellence in Tissue Engineering Chinese Academy of Medical Sciences, Beijing Key Laboratory (No. BZO381), Beijing 100005, China.

As the population ages, the medical and socioeconomic impact of age-related bone disorders will further increase. An imbalance between osteogenesis and adipogenesis of mesenchymal stem cells (MSCs) can lead to various bone and metabolic diseases such as osteoporosis. Thus, understanding the molecular mechanisms underlying MSC osteogenic and adipogenic differentiation is important for the discovery of novel therapeutic paradigms for these diseases. Read More

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http://dx.doi.org/10.14336/AD.2018.0214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284771PMC
December 2018
3 Reads

A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder.

Aging Dis 2018 Dec 4;9(6):1043-1057. Epub 2018 Dec 4.

2Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.

Aging is a complex biological process. A study of pyrroline-5-carboxylate reductase 1 (PYCR1) deficiency, which causes a progeroid syndrome, may not only shed light on its genetic contribution to autosomal recessive cutis laxa (ARCL) but also help elucidate the functional mechanisms associated with aging. In this study, we used RNA-Seq technology to examine gene expression changes in primary skin fibroblasts from healthy controls and patients with mutations. Read More

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http://dx.doi.org/10.14336/AD.2018.0222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284769PMC
December 2018
1 Read

Omi/HtrA2 Participates in Age-Related Autophagic Deficiency in Rat Liver.

Aging Dis 2018 Dec 4;9(6):1031-1042. Epub 2018 Dec 4.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Capital Medical University, Beijing, China.

Liver is a vital organ with many important functions, and the maintenance of normal hepatic function is necessary for health. As an essential mechanism for maintaining cellular homeostasis, autophagy plays an important role in ensuring normal organ function. Studies have indicated that the degeneration of hepatic function is associated with autophagic deficiency in aging liver. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0221
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http://dx.doi.org/10.14336/AD.2018.0221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284766PMC
December 2018
10 Reads

Relationship between Cortical Thickness and Neuropsychological Performance in Normal Older Adults and Those with Mild Cognitive Impairment.

Aging Dis 2018 Dec 4;9(6):1020-1030. Epub 2018 Dec 4.

6Department of Psychiatry, Tai Po Hospital, The Chinese University of Hong Kong, Hong Kong.

Mild cognitive impairment (MCI) has been extensively investigated in recent decades to identify groups with a high risk of dementia and to establish effective prevention methods during this period. Neuropsychological performance and cortical thickness are two important biomarkers used to predict progression from MCI to dementia. This study compares the cortical thickness and neuropsychological performance in people with MCI and cognitively healthy older adults. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0125
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http://dx.doi.org/10.14336/AD.2018.0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284757PMC
December 2018
1 Read

Stronger Association between Insomnia Symptoms and Shorter Telomere Length in Old HIV-Infected Patients Compared with Uninfected Individuals.

Aging Dis 2018 Dec 4;9(6):1010-1019. Epub 2018 Dec 4.

1Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

Growing evidence suggests that HIV infection may accelerate biological aging. Insomnia symptoms, particularly in later life, exacerbate cellular aging. We examined the association between insomnia symptoms and leukocyte telomere length (LTL), and further explored how this association was affected by HIV serostatus and age. Read More

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http://dx.doi.org/10.14336/AD.2018.0204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284770PMC
December 2018
1 Read

Relationship between White Matter Hyperintensities and Hematoma Volume in Patients with Intracerebral Hematoma.

Aging Dis 2018 Dec 4;9(6):999-1009. Epub 2018 Dec 4.

1Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China.

The relationship of white-matter hyperintensity (WMH) to intracerebral hemorrhage (ICH) remains unclear. In this retrospective study, we investigated whether the severity and progression of WMH could be related to the hematoma volume and absorption in ICH. 2338 WMH patients with ICH aged≥40 years receiving brain computed tomography (CT) imaging within 12 hours of ICH symptom onset were screened, and 227 patients were included in the final study. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0108
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http://dx.doi.org/10.14336/AD.2018.0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284763PMC
December 2018
12 Reads

Muscle Fatigue Does Not Change the Effects on Lower Limbs Strength Caused by Aging and Parkinson's Disease.

Aging Dis 2018 Dec 4;9(6):988-998. Epub 2018 Dec 4.

2Posture and Gait Studies Laboratory (LEPLO), Department of Physical Education, Sao Paulo State University (Unesp), Rio Claro, Brazil.

The aim of this study was to determine the impact of aging and Parkinson's disease (PD) on lower limb muscle strength before and after muscle fatigue. One hundred thirty-five individuals were distributed over seven groups according to their age (20, 30, 40, 50, 60, 70 years old) and disease. Participants performed maximum voluntary isometric contractions (MVIC) in a leg press device followed by the muscle fatigue protocol (repeated sit-to-stand task). Read More

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http://dx.doi.org/10.14336/AD.2018.0203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284767PMC
December 2018

Age-Related Changes in Femoral Head Trabecular Microarchitecture.

Aging Dis 2018 Dec 4;9(6):976-987. Epub 2018 Dec 4.

1Cranfield Forensic Institute, Cranfield University, Shrivenham, UK.

Osteoporosis is a prevalent bone condition, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density using dual energy X-ray absorption. However, many studies have shown that bone strength, and consequently the probability of fracture, is a combination of both bone mass and bone 'quality' (architecture and material chemistry). Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0124
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http://dx.doi.org/10.14336/AD.2018.0124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284768PMC
December 2018
11 Reads

Prognostic Nomogram Associated with Longer Survival in Amyotrophic Lateral Sclerosis Patients.

Aging Dis 2018 Dec 4;9(6):965-975. Epub 2018 Dec 4.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Better understanding of survival factors in amyotrophic lateral sclerosis (ALS) could help physicians and patients schedule therapeutic interventions. We conducted a study to evaluate the predictive factors associated with longer survival and construct prognostic nomogram in ALS patients. A total of 553 ALS patients were enrolled and divided into 2 groups: a training set and a validation set. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2017.1016
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http://dx.doi.org/10.14336/AD.2017.1016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284758PMC
December 2018
1 Read

Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection.

Aging Dis 2018 Dec 4;9(6):952-964. Epub 2018 Dec 4.

3Department of Orthopedics and Traumatology, "Tor Vergata" University of Rome, "Policlinico Tor Vergata" Foundation, Rome, Italy.

In this study, we investigated the relationship between sarcopenia (evaluated in term of fibers atrophy), vitamin d receptor protein expression and VDR genotypes in an Italian cohort of osteoporosis(n=44) and osteoarthritis (n=55) patients. Muscle biopsies were fixed and investigated by both immunohistochemistry (vitamin d receptor expression) and transmission electron microscopy (satellite stem cells niches). Vitamin d receptor polymorphisms were studied on DNA extracted from muscle paraffin sections. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0215
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http://dx.doi.org/10.14336/AD.2018.0215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284754PMC
December 2018
9 Reads

Low Molecular Weight Adiponectin Increases the Mortality Risk in Very Old Patients.

Aging Dis 2018 Oct 1;9(5):946-951. Epub 2018 Oct 1.

1Department of Systems Medicine, University of Rome Tor Vergata and.

Despite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been frequently reported as an independent positive predictor of cardiovascular mortality. Very few information is available regarding adiponectin isoforms and mortality, in particular in advanced aging. Baseline serum levels of Total Adiponectin and its circulating isoforms (HMW-, MMW-, LMW-Adiponectin) were measured in 97 old patients (mean age: 79 years). Read More

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http://dx.doi.org/10.14336/AD.2017.1117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147581PMC
October 2018

Nitrate and Nitrite in Health and Disease.

Aging Dis 2018 Oct 1;9(5):938-945. Epub 2018 Oct 1.

Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University, Beijing 100069, China.

The source of dietary nitrate (NO) is mainly green, leafy vegetables, partially absorbed into blood through intestinal mucosa. The recycled nitrate is reabsorbed and concentrated by the salivary glands and then secreted into saliva. In 2012, sialin was first discovered as the mammalian membrane nitrate transporter in salivary glands and plays a key role in circulation of inorganic nitrate, providing a scientific basis for further investigation into the circulation and functions of nitrate. Read More

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http://dx.doi.org/10.14336/AD.2017.1207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147587PMC
October 2018

Mitochondria in Ischemic Stroke: New Insight and Implications.

Aging Dis 2018 Oct 1;9(5):924-937. Epub 2018 Oct 1.

1Discipline of Neuroscience, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2017.1126
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http://dx.doi.org/10.14336/AD.2017.1126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147588PMC
October 2018
17 Reads

Effect of Rhythmic Auditory Cueing on Aging Gait: A Systematic Review and Meta-Analysis.

Aging Dis 2018 Oct 1;9(5):901-923. Epub 2018 Oct 1.

1Institute for Sports Science, Leibniz University Hannover, Germany.

Rhythmic auditory cueing has been widely used in gait rehabilitation over the past decade. The entrainment effect has been suggested to introduce neurophysiological changes, alleviate auditory-motor coupling and reduce cognitive-motor interferences. However, a consensus as to its influence over aging gait is still warranted. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2017.1031
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http://dx.doi.org/10.14336/AD.2017.1031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147584PMC
October 2018
2 Reads

Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging.

Aging Dis 2018 Oct 1;9(5):880-900. Epub 2018 Oct 1.

3University of Limoges, Faculty of Pharmacy, Department of Physiology, EA 6309, F-87025 Limoges, France.

Glycation is both a physiological and pathological process which mainly affects proteins, nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious reactions that take place principally in the extracellular matrix environment or within the cell cytosol and organelles. Advanced glycation end product (AGE) formation begins by the non-enzymatic glycation of free amino groups by sugars and aldehydes which leads to a succession of rearrangements of intermediate compounds and ultimately to irreversibly bound products known as AGEs. Read More

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http://dx.doi.org/10.14336/AD.2017.1121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147582PMC
October 2018
14 Reads

Limb Ischemic Conditioning Improved Cognitive Deficits via eNOS-Dependent Augmentation of Angiogenesis after Chronic Cerebral Hypoperfusion in Rats.

Aging Dis 2018 Oct 1;9(5):869-879. Epub 2018 Oct 1.

1Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Intracranial and extracranial arterial stenosis, the primary cause of chronic cerebral hypoperfusion (CCH), is a critical reason for the pathogenesis of vascular dementia and Alzheimer's disease characterized by cognitive impairments. Our previous study demonstrated that limb remote ischemic conditioning (LRIC) improved cerebral perfusion in intracranial arterial stenosis patients. The current study aimed to test whether LRIC promotes angiogenesis and increases phosphorylated endothelial nitric oxide synthase (p-eNOS) activity in CCH rat model. Read More

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http://dx.doi.org/10.14336/AD.2017.1106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147592PMC
October 2018
17 Reads

Transcultural Adaptation and Validation of the Spanish Bristol Foot Score (BFS-S).

Aging Dis 2018 Oct 1;9(5):861-868. Epub 2018 Oct 1.

7Nursing and Physical Therapy Department, Institute of Biomedicine (IBIOMED), Universidad de Leon, Ponferrada, Leon, Spain.

The Bristol Foot Score is considered an instrument for measuring the impact of foot problems and pain. It was developed and validated in United Kingdom. Therefore, this aim was to perform the transcultural adaptation and validation of the Spanish version. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2017.1215
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http://dx.doi.org/10.14336/AD.2017.1215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147586PMC
October 2018
16 Reads

Gender Differences among Elderly Patients with Primary Percutaneous Coronary Intervention.

Aging Dis 2018 Oct 1;9(5):852-860. Epub 2018 Oct 1.

1Departments of Cardiology, Suzhou Kowloon Hospital, School of Medicine Shanghai Jiaotong University, Suzhou, 215000, China.

Several epidemiological and clinical studies have shown that females with ST-segment elevation myocardial infarction (STEMI) have a higher mortality than males following primary percutaneous coronary intervention (PPCI). Many analyses of sex-based differences following STEMI have revealed conflicting results. Currently, more and more elderly patients with STEMI have undergone emergency interventional therapy. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2017.1129
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http://dx.doi.org/10.14336/AD.2017.1129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147591PMC
October 2018
18 Reads

NLRC3: A Novel Noninvasive Biomarker for Pulmonary Hypertension Diagnosis.

Aging Dis 2018 Oct 1;9(5):843-851. Epub 2018 Oct 1.

1Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

The nucleotide-oligomerization domain (NOD)-like receptor subfamily C3 (NLRC3) is a newly discovered and incompletely characterized member of the NLR family which negatively regulates inflammatory responses. Inflammation is considered a critical pathogenesis in pulmonary hypertension (PH). This is the first study to hypothesize that NLRC3 is closely correlated with PH. Read More

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http://dx.doi.org/10.14336/AD.2017.1102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147585PMC
October 2018
1 Read

Searching for Factors Raising the Incidence of Metabolic Syndrome Among 45-60-Year-Old Women.

Aging Dis 2018 Oct 1;9(5):831-842. Epub 2018 Oct 1.

1Department of Nursing, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Metabolic syndrome is an increasing health problem, whose pathogenesis may be associated with genetic factors. The main purpose of our study was to assess relationships between MetS and the presence of the rs9939609, the rs17782313, and the rs1801282 polymorphisms in 45-60-year-old women. The study included patients from the general population of the Westpomeranian Province (Poland). Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2017.1027
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http://dx.doi.org/10.14336/AD.2017.1027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147583PMC
October 2018
18 Reads

Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus.

Aging Dis 2018 Oct 1;9(5):817-830. Epub 2018 Oct 1.

1Clinical Pharmacology, Goethe-University Hospital Frankfurt am Main, Germany.

Loss-of-function mutations of progranulin are associated with frontotemporal dementia in humans, and its deficiency in mice is a model for this disease but with normal life expectancy and mild cognitive decline on aging. The present study shows that aging progranulin deficient mice develop progressive polydipsia and polyuria under standard housing conditions starting at middle age (6-9 months). They showed high water licking behavior and doubling of the normal daily drinking volume, associated with increased daily urine output and a decrease of urine osmolality, all maintained during water restriction. Read More

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http://dx.doi.org/10.14336/AD.2017.1127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147595PMC
October 2018
14 Reads

The Effect of Aquaporin-4 Knockout on Interstitial Fluid Flow and the Structure of the Extracellular Space in the Deep Brain.

Aging Dis 2018 Oct 1;9(5):808-816. Epub 2018 Oct 1.

1Department of Radiology, Peking University Third Hospital, Beijing 100191, China.

It has been reported that aquaporin-4 (AQP4) deficiency impairs transportation between the cerebrospinal fluid and interstitial fluid (ISF) as well as the clearance of interstitial solutes in the superficial brain. However, the effect of AQP4 on ISF flow in the deep brain remains unclear. This study compared the brain ISF flow in the caudate nucleus and thalamus of normal rats (NO) and AQP4 knockout rats (KO) using tracer-based magnetic resonance imaging. Read More

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http://dx.doi.org/10.14336/AD.2017.1115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147590PMC
October 2018
10 Reads

Age-related Deficits in Recognition Memory are Protocol-Dependent.

Aging Dis 2018 Oct 1;9(5):798-807. Epub 2018 Oct 1.

1Dept. of Psychology, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.

The perirhinal cortex (PRh) is a critical mediator of recognition memory, and a wealth of evidence points to impairment in PRh function with age. Despite this evidence, age-related deficits in recognition memory are not consistently observed. This may be partially due to the fact that older animals also have well-established deficits in hippocampal function, and many protocols that assess perirhinal function are also sensitive to hippocampal damage. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2017.1223
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http://dx.doi.org/10.14336/AD.2017.1223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147594PMC
October 2018
3 Reads

The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease.

Aging Dis 2018 Oct 1;9(5):785-797. Epub 2018 Oct 1.

2Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.

Aging is an inevitable physiological challenge occurring in organisms over time, and is also the most important risk factor of neurodegenerative diseases. In this study, we observed cellular and molecular changes of different age mice and LPS-induced Parkinson disease (PD) model. The results showed that behavioral performance and dopaminergic (DA) neurons were declined, accompanied by increased expression of pro-inflammatory factors (TLR2, p-NF-kB-p65, IL-1β and TNF-α), as well as pro-oxidative stress factor gp91phox in aged mice compared with young mice. Read More

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http://dx.doi.org/10.14336/AD.2017.1028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147589PMC
October 2018
18 Reads

Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia.

Aging Dis 2018 Oct 1;9(5):769-784. Epub 2018 Oct 1.

1System Biology Department, Alcala University, Alcalá de Henares, Madrid, Spain.

In mammalians, advancing age is associated with sarcopenia, the progressive and involuntary loss of muscle mass and strength. Hyperphosphatemia is an aging-related condition involved in several pathologies. The aim of this work was to assess whether hyperphosphatemia plays a role in the age-related loss of mass muscle and strength by inducing cellular senescence in murine myoblasts and to explore the intracellular mechanism involved in this effect. Read More

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http://dx.doi.org/10.14336/AD.2017.1214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147593PMC
October 2018
6 Reads