624 results match your criteria Aging and disease[Journal]


The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer's Disease-related Pathogenesis.

Aging Dis 2020 May 9;11(3):705-724. Epub 2020 May 9.

1Department of Biochemistry, College of Medicine, Konyang University, Daejeon, 35365, Republic of Korea.

Several studies have revealed that the transcription factor nuclear receptor related 1 (Nurr1) plays several roles not only in the regulation of gene expression related to dopamine synthesis, but also in alternative splicing, and miRNA targeting. Moreover, it regulates cognitive functions and protects against inflammation-induced neuronal death. In particular, the role of Nurr1 in the pathogenesis of Parkinson's disease (PD) has been well investigated; for example, it has been shown that it restores behavioral and histological impairments in PD models. Read More

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http://dx.doi.org/10.14336/AD.2019.0718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220289PMC

Implications of Long Non-Coding RNAs in Age-Altered Proteostasis.

Aging Dis 2020 May 9;11(3):692-704. Epub 2020 May 9.

4MEDFUTURE - Research Center for Advanced Medicine, Cluj-Napoca, Romania.

This review aims to summarize the current knowledge on how lncRNAs are influencing aging and cancer metabolism. Recent research has shown that senescent cells re-enter cell-cycle depending on intrinsic or extrinsic factors, thus restoring tissue homeostasis in response to age-related diseases (ARDs). Furthermore, maintaining proteostasis or cellular protein homeostasis requires a correct quality control (QC) of protein synthesis, folding, conformational stability, and degradation. Read More

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http://dx.doi.org/10.14336/AD.2019.0814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220293PMC

Parkinson Disease and Orthostatic Hypotension in the Elderly: Recognition and Management of Risk Factors for Falls.

Aging Dis 2020 May 9;11(3):679-691. Epub 2020 May 9.

3University of South Florida Parkinson's Disease and Movement Disorders Center, Parkinson Foundation Center of Excellence, Tampa, FL 33613, USA.

Parkinson disease (PD) is often associated with postural instability and gait dysfunction that can increase the risk for falls and associated consequences, including injuries, increased burden on healthcare resources, and reduced quality of life. Patients with PD have nearly twice the risk for falls and associated bone fractures compared with their general population counterparts of similar age. Although the cause of falls in patients with PD may be multifactorial, an often under-recognized factor is neurogenic orthostatic hypotension (nOH). Read More

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http://dx.doi.org/10.14336/AD.2019.0805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220277PMC

Comorbid Chronic Diseases are Strongly Correlated with Disease Severity among COVID-19 Patients: A Systematic Review and Meta-Analysis.

Aging Dis 2020 May 9;11(3):668-678. Epub 2020 May 9.

4Department of Endocrinology & Metabolism, Zhuhai Hospital Affiliated with Jinan University, Zhuhai People's Hospital, Zhuhai, China.

Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. In order to explore the effects of comorbid chronic diseases on clinical outcomes of COVID-19, a search was conducted in PubMed, Ovid MEDLINE, EMBASE, CDC, and NIH databases to April 25, 2020. A total of 24 peer-reviewed articles, including 10948 COVID-19 cases were selected. Read More

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http://dx.doi.org/10.14336/AD.2020.0502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220287PMC

Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone.

Authors:
Chin-Hsiao Tseng

Aging Dis 2020 May 9;11(3):658-667. Epub 2020 May 9.

1Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

This population-based retrospective cohort study investigated dementia risk associated with acarbose in patients with type 2 diabetes mellitus by using Taiwan's National Health Insurance database. A cohort of 15,524 matched pairs of ever and never users of acarbose based on propensity score matching was enrolled from new-onset type 2 diabetes patients from 1999 to 2006. Patients who were alive on January 1, 2007, were followed up for dementia until December 31, 2011. Read More

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http://dx.doi.org/10.14336/AD.2019.0621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220278PMC

Management of The Elderly Cancer Patients Complexity: The Radiation Oncology Potential.

Aging Dis 2020 May 9;11(3):649-657. Epub 2020 May 9.

1Fondazione Policlinico Universitario Agostino Gemelli IRCCS, UOC di Radioterapia, Dipartimento di Scienze Radiologiche, Radioterapiche ed Ematologiche, Roma, Italy.

Radiation oncology has the potential to be an excellent option for the frail elderly cancer patients because of its limited systemic toxicities. It can be effective for curative, prophylactic, disease control or palliative purposes. Currently about 60% of all cancer patients undergoing active treatment at some point receive radiation treatment. Read More

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http://dx.doi.org/10.14336/AD.2019.0616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220284PMC

Immune Characteristics of Patients with Coronavirus Disease 2019 (COVID-19).

Aging Dis 2020 May 9;11(3):642-648. Epub 2020 May 9.

3State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Up to now, little is known about the detailed immune profiles of COVID-19 patients from admission to discharge. In this study we retrospectively reviewed the clinical and laboratory characteristics of 18 COVID-19 patients from January 30, 2020 to February 21, 2020. These patients were divided into two groups; group 1 had a severe acute respiratory syndrome coronavirus 2 nucleic acid-positive duration for more than 15 days (n = 6) and group 2 had a nucleic acid-positive duration for less than 15 days (n = 12). Read More

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http://dx.doi.org/10.14336/AD.2020.0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220292PMC

Lactulose Suppresses Osteoclastogenesis and Ameliorates Estrogen Deficiency-Induced Bone Loss in Mice.

Aging Dis 2020 May 9;11(3):629-641. Epub 2020 May 9.

1Department of Orthopedics Trauma, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China.

Postmenopausal osteoporosis is characterized by excess osteoclastogenesis which leads to net bone loss and brittle fractures. Studies have demonstrated that estrogen deficiency-associated bone loss is microbiota-dependent and could be prevented by probiotics and prebiotics. In this study, we report that orally administered lactulose (20 g/kg, 6 weeks) orally administered significantly inhibited osteoclastogenesis, bone resorption, and prevented ovariectomy (OVX)-induced bone loss in mice. Read More

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http://dx.doi.org/10.14336/AD.2019.0613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220299PMC

T1-weighted MRI-driven Brain Age Estimation in Alzheimer's Disease and Parkinson's Disease.

Aging Dis 2020 May 9;11(3):618-628. Epub 2020 May 9.

1Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.

Neuroimaging-driven brain age estimation has introduced a robust (reliable and heritable) biomarker for detecting and monitoring neurodegenerative diseases. Here, we computed and compared brain age in Alzheimer's disease (AD) and Parkinson's disease (PD) patients using an advanced machine learning procedure involving T1-weighted MRI scans and gray matter (GM) and white matter (WM) models. Brain age estimation frameworks were built using 839 healthy individuals and then the brain estimated age difference (Brain-EAD: chronological age subtracted from brain estimated age) was assessed in a large sample of PD patients (n = 160) and AD patients (n = 129), respectively. Read More

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http://dx.doi.org/10.14336/AD.2019.0617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220281PMC

SRμCT Reveals 3D Microstructural Alterations of the Vascular and Neuronal Network in a Rat Model of Chronic Compressive Thoracic Spinal Cord Injury.

Aging Dis 2020 May 9;11(3):603-617. Epub 2020 May 9.

1Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, China.

The complex pathology of chronic thoracic spinal cord compression involves vascular and neuroarchitectural repair processes that are still largely unknown. In this study, we used synchrotron radiation microtomography (SRμCT) to quantitatively characterize the 3D temporal-spatial changes in the vascular and neuronal network after chronic thoracic spinal cord compression in order to obtain further insights into the pathogenesis of this disease and to elucidate its underlying mechanisms. Direct 3D characterization of the spinal cord microvasculature and neural microstructure of the thoracic spinal cord was successfully reconstructed. Read More

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http://dx.doi.org/10.14336/AD.2019.0529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220295PMC

Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice.

Aging Dis 2020 May 9;11(3):588-602. Epub 2020 May 9.

Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Dipeptidyl peptidase 4 (DPP-4) inhibitors exert pleiotropic effects beyond glycemic control. We investigated the renoprotective effects of DPP-4 inhibitors on aging mice mediated by the renin-angiotensin system (RAS). C57BL/6 mice were divided into three groups: the two-month-old mice (YM group), the eighteen-month-old mice (AM group) and the eighteen-month-old, linagliptin-treated mice (AM + LIN group). Read More

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http://dx.doi.org/10.14336/AD.2019.0620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220286PMC

Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction.

Aging Dis 2020 May 9;11(3):575-587. Epub 2020 May 9.

2College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.

Aging-related adipose tissue dysfunction contributes to the progression of chronic metabolic diseases. We investigated the role of age-dependent expression of a neurotrophin, brain-derived neurotrophic factor (BDNF) in adipose tissue. Pro-BDNF expression was elevated in epididymal white adipose tissue (eWAT) with advanced age, which was associated with the reduction in sympathetic innervation. Read More

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http://dx.doi.org/10.14336/AD.2019.0810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220283PMC

Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection Activation of Immunoproteasome.

Aging Dis 2020 May 9;11(3):559-574. Epub 2020 May 9.

1State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Parkinson's disease (PD), the second most common neurodegenerative disorder, is neuropathologically characterized by the loss of dopaminergic neurons in the (SNc) and the presence of Lewy bodies in surviving neurons. α-synuclein (α-syn) is the major component of Lewy bodies and its deposition in neurons is critical pathological event in the pathogenesis of PD. Herein, we reported that Oxyphylla A, a novel lead compound from the fruit of , significantly promoted α-syn degradation in a cellular PD model. Read More

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http://dx.doi.org/10.14336/AD.2019.0612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220298PMC

Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia.

Aging Dis 2020 May 9;11(3):547-558. Epub 2020 May 9.

2Department of Neurosurgery and.

The receptor for advanced glycation end-products (RAGE) is expressed on human brain endothelial cells (HBEC) and is implicated in neuronal cell death after ischemia. We report that endogenous secretory RAGE (esRAGE) is a splicing variant form of RAGE that functions as a decoy against ischemia-induced neuronal cell damage. This study demonstrated that esRAGE was associated with heparan sulphate proteoglycans on HBEC. Read More

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http://dx.doi.org/10.14336/AD.2019.0715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220285PMC

Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients.

Aging Dis 2020 May 9;11(3):536-546. Epub 2020 May 9.

1Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.

The molecular processes of aging are very heterogenic and not fully understood. Studies on rare progeria syndromes, which display an accelerated progression of physiological aging, can help to get a better understanding. Pseudoxanthoma elasticum (PXE) caused by mutations in the () gene shares some molecular characteristics with such premature aging diseases. Read More

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http://dx.doi.org/10.14336/AD.2019.0610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220280PMC

Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury.

Aging Dis 2020 May 9;11(3):523-535. Epub 2020 May 9.

2The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.

Neuroinflammation plays a critical role in ischemia-induced brain injury. Mib2, an E3 ubiquitin ligase, has been reported to regulate Notch signaling and participate in the peripheral immune system. However, the roles of Mib2 in the nervous system are not well characterized. Read More

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http://dx.doi.org/10.14336/AD.2019.0807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220279PMC

COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile.

Aging Dis 2020 May 9;11(3):509-522. Epub 2020 May 9.

1Department of Medicine, Augusta University, Augusta, GA, USA.

The World health organization (WHO) declared Coronavirus disease 2019 (COVID-19) a global pandemic and a severe public health crisis. Drastic measures to combat COVID-19 are warranted due to its contagiousness and higher mortality rates, specifically in the aged patient population. At the current stage, due to the lack of effective treatment strategies for COVID-19 innovative approaches need to be considered. Read More

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http://dx.doi.org/10.14336/AD.2020.0428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220294PMC

Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering.

Aging Dis 2020 May 9;11(3):494-508. Epub 2020 May 9.

1State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Leukocytes telomere length has been associated with hypertension, but, whether longitudinal telomeres change could serve as a useful predictive tool in hypertension remains uncertain. This study aimed to examine the longitudinal trajectory of leukocytes telomere length in a population-based prospective study of 1,108 individuals with hypertension. Leukocytes telomere length were measured at baseline and again after a median 2. Read More

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http://dx.doi.org/10.14336/AD.2019.0721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220288PMC

Whole-lung Low Dose Irradiation for SARS-Cov2 Induced Pneumonia in the Geriatric Population: An Old Effective Treatment for a New Disease? Recommendation of the International Geriatric Radiotherapy Group.

Aging Dis 2020 May 9;11(3):489-493. Epub 2020 May 9.

15Department of Radiation Oncology, Baclesse Cancer Center, Caen, France.

A cytokine storm induced by SARS-Cov2 may produce pneumonitis which may be fatal for older patients with underlying lung disease. Hyper-elevation of Interleukin1 (IL-1), Tumor necrosis factor-1alfa (TNF-1 alfa), and Interleukin 6 (IL-6) produced by inflammatory macrophage M1 may damage the lung alveoli leading to severe pneumonitis, decreased oxygenation, and potential death despite artificial ventilation. Older patients may not be suitable candidates for pharmaceutical intervention targeting IL-1/6 blockade or artificial ventilation. Read More

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http://dx.doi.org/10.14336/AD.2020.0506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220282PMC

COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?

Aging Dis 2020 May 9;11(3):480-488. Epub 2020 May 9.

17Department of Biochemistry and Central Research Cell, MM Institute of Medical Sciences & Research, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.

The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable steps to curtail the community spread of COVID-19. Read More

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http://dx.doi.org/10.14336/AD.2020.0402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220291PMC

Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes?

Aging Dis 2020 May 9;11(3):477-479. Epub 2020 May 9.

Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Faculty of Science, Ankara University, Ankara, Turkey.

Mesenchymal stem cells (MSCs) bear a promising potential for regenerative medicine therapies and they repair damaged tissue through secretion of immune modulatory and anti-inflammatory molecules acting in a paracrine fashion. Coronavirus disease 2019 (COVID-19) has spread all over the world with high morbidity and mortality rates and there is no specific treatment for this infection. A recent study published in the journal reports that MSC infusion is safe and effective in patients suffering from COVID-19 induced pneumonia. Read More

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http://dx.doi.org/10.14336/AD.2020.0403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220290PMC

Molecular Aging Markers in Patients with Klinefelter Syndrome.

Aging Dis 2020 May 9;11(3):470-476. Epub 2020 May 9.

3Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University of Münster, 48149 Münster, Germany.

Molecular aging markers provide the opportunity for biological age determination in humans and to study factors, such as genetic determinants, affecting the ageing process. In males with Klinefelter syndrome (KS, non-mosaic karyotype 47, XXY), which is the most common sex chromosome aneuploidy, age-related morbidity and mortality are increased, and a significantly reduced life span has been observed. The aim of this study was to investigate whether Klinefelter patients exhibit molecular signs of premature ageing. Read More

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http://dx.doi.org/10.14336/AD.2019.0801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220296PMC

Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease.

Aging Dis 2020 May 9;11(3):465-469. Epub 2020 May 9.

2Department of Plastic and Reconstructive Surgery, Metropolitan General Hospital, Athens, Greece.

A recent and interesting study reported improved respiratory activity after intravenous administration of mesenchymal stem cells (MSCs) into patients affected by coronavirus disease 2019 (COVID-19). These outcomes displayed that intravenous infiltration of MSCs is a safe and efficacy treatment for COVID-19 pneumonia, a severe acute respiratory illness caused by the coronavirus 2 (SARS-CoV-2). Only 7 patients were treated, but with extraordinary results, opening a new strategy in COVID-19 therapy. Read More

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http://dx.doi.org/10.14336/AD.2020.0422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220297PMC

Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia.

Authors:
Ashok K Shetty

Aging Dis 2020 Apr 9;11(2):462-464. Epub 2020 Mar 9.

Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, Texas A&M University College of Medicine, College Station, Texas, USA.

A new study published by the journal Aging & Disease reported that intravenous administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with coronavirus disease 2019 (COVID-19) resulted in improved functional outcomes (). This study demonstrated that intravenous infusion of MSCs is a safe and effective approach for treating patients with COVID-19 pneumonia, including elderly patients displaying severe pneumonia. COVID-19 is a severe acute respiratory illness caused by a new coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

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http://dx.doi.org/10.14336/AD.2020.0301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069463PMC

Pretreatment Geriatric Assessments of Elderly Patients with Glioma: Development and Implications.

Aging Dis 2020 Apr 9;11(2):448-461. Epub 2020 Mar 9.

Departments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Glioma is the most frequent primary brain tumor affecting adults, and the most lethal type is glioblastoma (GBM); currently, the available therapies only provide palliation. The treatments for low-grade glioma (LGG) include neurosurgical resection, watchful waiting, radiotherapy and chemotherapy, while the therapeutic strategies for high-grade glioma (HGG), particularly in elderly patients, have evolved to include radiotherapy, chemotherapy, and targeted monotherapy based on the characteristics of the investigated patients. Proper assessments aiming to predict and achieve the most satisfying prognosis among patients prior to surgery, radiotherapy, chemotherapy, targeted therapy or immunotherapy help summarize the pretreatment characteristics of patients, providing doctors comprehensive information to consider while determining whether the patients could benefit from ongoing treatments and deciding the proper treatment strategy for subsequent phases. Read More

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http://dx.doi.org/10.14336/AD.2019.0527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069455PMC

Gut Microbiome and Osteoporosis.

Aging Dis 2020 Apr 9;11(2):438-447. Epub 2020 Mar 9.

1Department of Trauma Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Gut microbiome refers to the microbes that live in human digestive tract and are symbiotic with the human body. They participate in the regulation of various physiological and pathological processes of the human body and are associated with various diseases. The pathological process of osteoporosis is affected by gut microbes. Read More

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http://dx.doi.org/10.14336/AD.2019.0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069453PMC

Role of Mitophagy in Cardiovascular Disease.

Aging Dis 2020 Apr 9;11(2):419-437. Epub 2020 Mar 9.

Department of Cardiology, The Second Hospital of Jilin University, Changchun 130041, China.

Cardiovascular disease is the leading cause of mortality worldwide, and mitochondrial dysfunction is the primary contributor to these disorders. Recent studies have elaborated on selective autophagy-mitophagy, which eliminates damaged and dysfunctional mitochondria, stabilizes mitochondrial structure and function, and maintains cell survival and growth. Numerous recent studies have reported that mitophagy plays an important role in the pathogenesis of various cardiovascular diseases. Read More

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http://dx.doi.org/10.14336/AD.2019.0518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069452PMC

Understanding the Physiological Links Between Physical Frailty and Cognitive Decline.

Authors:
Lina Ma Piu Chan

Aging Dis 2020 Apr 9;11(2):405-418. Epub 2020 Mar 9.

1Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.

Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical frailty to cognitive decline, a complete understanding of the underpinning biological basis of the two disorders remains fragmented. Read More

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http://dx.doi.org/10.14336/AD.2019.0521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069469PMC

Alteration in the Function and Expression of SLC and ABC Transporters in the Neurovascular Unit in Alzheimer's Disease and the Clinical Significance.

Aging Dis 2020 Apr 9;11(2):390-404. Epub 2020 Mar 9.

1Department of Neuropharmacology, College of Pharmacy, Qiqihar Medical University, Qiqihar, China.

The neurovascular unit (NVU) plays an important role in maintaining the function of the central nervous system (CNS). Emerging evidence has indicated that the NVU changes function and molecules at the early stage of Alzheimer's disease (AD), which initiates multiple pathways of neurodegeneration. Cell types in the NVU have become attractive targets in the interventional treatment of AD. Read More

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http://dx.doi.org/10.14336/AD.2019.0519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069460PMC

Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review.

Aging Dis 2020 Apr 9;11(2):378-389. Epub 2020 Mar 9.

1 Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy. Read More

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http://dx.doi.org/10.14336/AD.2019.09603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069461PMC

Aging Attenuates Cardiac Contractility and Affects Therapeutic Consequences for Myocardial Infarction.

Aging Dis 2020 Apr 9;11(2):365-376. Epub 2020 Mar 9.

1Department of Pathophysiology, Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Guangdong, China.

Cardiac function of the human heart changes with age. The age-related change of systolic function is subtle under normal conditions, but abrupt under stress or in a pathogenesis state. Aging decreases the cardiac tolerance to stress and increases susceptibility to ischemia, which caused by aging-induced Ca transient impairment and metabolic dysfunction. Read More

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http://dx.doi.org/10.14336/AD.2019.0522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069457PMC

Hypoxia-Induced Degenerative Protein Modifications Associated with Aging and Age-Associated Disorders.

Aging Dis 2020 Apr 9;11(2):341-364. Epub 2020 Mar 9.

1School of Biological Sciences, Nanyang Technological University, Singapore.

Aging is an inevitable time-dependent decline of various physiological functions that finally leads to death. Progressive protein damage and aggregation have been proposed as the root cause of imbalance in regulatory processes and risk factors for aging and neurodegenerative diseases. Oxygen is a modulator of aging. Read More

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http://dx.doi.org/10.14336/AD.2019.0604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069466PMC

A Review of Exercise as Medicine in Cardiovascular Disease: Pathology and Mechanism.

Aging Dis 2020 Apr 9;11(2):327-340. Epub 2020 Mar 9.

1Laboratory of Genetics, Department of Dance and Gymnastics, Poznań University of Physical Education, Poznań, Poland.

Background: Physical inactivity and resultant lower energy expenditure contribute unequivocally to cardiovascular diseases, such as coronary artery disease and stroke, which are considered major causes of disability and mortality worldwide.

Aim: The aim of the study was to investigate the influence of physical activity (PA) and exercise on different aspects of health - genetics, endothelium function, blood pressure, lipid concentrations, glucose intolerance, thrombosis, and self - satisfaction. Materials and. Read More

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http://dx.doi.org/10.14336/AD.2019.0516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069454PMC

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update.

Aging Dis 2020 Apr 9;11(2):315-326. Epub 2020 Mar 9.

1Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, China.

Rapid eye movement sleep behavior disorder (RBD) is a sleep behavior disorder characterized by abnormal behaviors and loss of muscle atonia during rapid eye movement (REM) sleep. RBD is generally considered to be associated with synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), and usually precedes years before the first symptom of these diseases. It is believed that RBD predicts the neurodegeneration in synucleinopathy. Read More

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http://dx.doi.org/10.14336/AD.2019.0324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069464PMC

Impaired Frontoparietal Connectivity in Traumatic Individuals with Disorders of Consciousness: A Dynamic Brain Network Analysis.

Aging Dis 2020 Apr 9;11(2):301-314. Epub 2020 Mar 9.

1Department of Neurology & Brain Medical Centre, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Recent advances in neuroimaging have demonstrated that patients with disorders of consciousness (DOC) may retain residual consciousness through activation of a complex functional brain network. However, an understanding of the hierarchy of residual consciousness and dynamic network connectivity in DOC patients is lacking. This study aimed to investigate residual consciousness and the dynamics of neural processing in DOC patients. Read More

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http://dx.doi.org/10.14336/AD.2019.0606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069467PMC

Exogenous HS Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts.

Aging Dis 2020 Apr 9;11(2):286-300. Epub 2020 Mar 9.

1Department of Pathophysiology, Harbin Medical University, Harbin, China.

Hydrogen sulfide (HS) plays physiological roles in vascular tone regulation, cytoprotection, and ATP synthesis. HMG-CoA reductase degradation protein (Hrd1), an E3 ubiquitin ligase, is involved in protein trafficking. HS may play a role in controlling fatty acid uptake in diabetic cardiomyopathy (DCM) in a manner correlated with modulation of Hrd1 S-sulfhydration; however, this role remains to be elucidated. Read More

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http://dx.doi.org/10.14336/AD.2019.0530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069459PMC

Exogenous HS Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.

Aging Dis 2020 Apr 9;11(2):269-285. Epub 2020 Mar 9.

1Department of Pathophysiology, Harbin Medical University, Harbin, China.

Hydrogen sulfide (HS), an important gasotransmitter, regulates cardiovascular functions. Mitochondrial damage induced by the overproduction of reactive oxygen species (ROS) results in myocardial injury with a diabetic state. The purpose of this study was to investigate the effects of exogenous HS on mitophagy formation in diabetic cardiomyopathy. Read More

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http://dx.doi.org/10.14336/AD.2019.0524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069468PMC

Disease Progression-Dependent Expression of CD200R1 and CX3CR1 in Mouse Models of Parkinson's Disease.

Aging Dis 2020 Apr 9;11(2):254-268. Epub 2020 Mar 9.

1Department of Neurobiology, Center of Parkinson Disease Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson Disease, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, China.

Microglial activation is an important contributor to the pathogenesis of Parkinson's disease (PD). Microglia are tightly and efficiently regulated by immune checkpoints, including CD200-CD200R1 and CX3CL1-CX3CR1. Understanding the involvement of these checkpoints in disease progression provides important insights into how microglial activation contributes to PD pathology. Read More

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http://dx.doi.org/10.14336/AD.2019.0615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069458PMC

Divergent Effect of Tacalcitol (PRI-2191) on Th17 Cells in 4T1 Tumor Bearing Young and Old Ovariectomized Mice.

Aging Dis 2020 Apr 9;11(2):241-253. Epub 2020 Mar 9.

1Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.

Vitamin D and its analogs are known for their role in the development of breast cancer and in immunomodulation. Our previous studies have shown the pro-metastatic effect of calcitriol and tacalcitol (PRI-2191) in young mice bearing 4T1 breast cancer and the anti-metastatic effect in aged ovariectomized (OVX) mice. Therefore, the aim of our work was to characterize Th17 cell population in young and aged OVX mice bearing 4T1 tumors treated with calcitriol and PRI-2191. Read More

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http://dx.doi.org/10.14336/AD.2019.0618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069462PMC

Ketogenic Diet Ameliorates Cardiac Dysfunction via Balancing Mitochondrial Dynamics and Inhibiting Apoptosis in Type 2 Diabetic Mice.

Aging Dis 2020 Apr 9;11(2):229-240. Epub 2020 Mar 9.

1Division of cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

The ketogenic diet (KD) has been widely used in clinical studies and shown to hace an anti-diabetic effect, but the underlying mechanisms have not been fully elaborated. Our aim was to investigate the effects and the underling mechanisms of the KD on cardiac function in db/db mice. In the present study, db/db mice were subjected to a normal diet (ND) or KD. Read More

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http://dx.doi.org/10.14336/AD.2019.0510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069456PMC

Transplantation of ACE2 Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia.

Aging Dis 2020 Apr 9;11(2):216-228. Epub 2020 Mar 9.

1School of Life Sciences, Shanghai University, Shanghai, China.

A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia. Mesenchymal stem cells (MSCs) have been shown to possess a comprehensive powerful immunomodulatory function. Read More

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http://dx.doi.org/10.14336/AD.2020.0228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069465PMC

The Urgent Need for International Action for Anti-aging and Disease Prevention.

Aging Dis 2020 Feb 1;11(1):212-215. Epub 2020 Feb 1.

2The Geriatric Medical Center "Shmuel Harofe", Beer Yaakov, affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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http://dx.doi.org/10.14336/AD.2019.1230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961764PMC
February 2020

The Interstitial System of the Brain in Health and Disease.

Aging Dis 2020 Feb 1;11(1):200-211. Epub 2020 Feb 1.

2Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.

The brain interstitial fluid (ISF) and the cerebrospinal fluid (CSF) cushion and support the brain cells. The ISF occupies the brain interstitial system (ISS), whereas the CSF fills the brain ventricles and the subarachnoid space. The brain ISS is an asymmetrical, tortuous, and exceptionally confined space between neural cells and the brain microvasculature. Read More

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http://dx.doi.org/10.14336/AD.2020.0103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961771PMC
February 2020

Macrophages in Noise-Exposed Cochlea: Changes, Regulation and the Potential Role.

Aging Dis 2020 Feb 1;11(1):191-199. Epub 2020 Feb 1.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Acoustic trauma is an important physical factor leading to cochlear damage and hearing impairments. Inflammation responds to this kind of cochlear damage stress. Macrophages, the major innate immune cells in the cochlea, are important drivers of inflammatory and tissue repair responses after cochlear injury. Read More

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http://dx.doi.org/10.14336/AD.2019.0723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961779PMC
February 2020

The Paradoxical Effect of Deep Brain Stimulation on Memory.

Aging Dis 2020 Feb 1;11(1):179-190. Epub 2020 Feb 1.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Deep brain stimulation (DBS) is a promising treatment for many memory-related disorders including dementia, anxiety, and addiction. However, the use of DBS can be a paradoxical conundrum-dementia treatments aim to improve memory, whereas anxiety or addiction treatments aim to suppress maladaptive memory. In this review, the key hypotheses on how DBS affects memory are highlighted. Read More

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http://dx.doi.org/10.14336/AD.2019.0511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961776PMC
February 2020

Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging.

Aging Dis 2020 Feb 1;11(1):164-178. Epub 2020 Feb 1.

Department of Geriatrics, Institute of Aging and Geriatrics, the Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Aging is a progressive loss of physiological integrity and functionality process which increases susceptibility and mortality to diseases. Vascular aging is a specific type of organic aging. The structure and function changes of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cause of vascular aging, which could influence the threshold, process, and severity of vascular related diseases. Read More

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http://dx.doi.org/10.14336/AD.2019.0402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961769PMC
February 2020

The Emerging Role of Sestrin2 in Cell Metabolism, and Cardiovascular and Age-Related Diseases.

Aging Dis 2020 Feb 1;11(1):154-163. Epub 2020 Feb 1.

1Cardiovascular Center, First Affiliated Hospital of Jilin University, Changchun, Jilin, China.

Sestrins (Sesns), including Sesn1, Sesn2, and Sesn3, are cysteine sulfinyl reductases that play critical roles in the regulation of peroxide signaling and oxidant defense. Sesn2 is thought to regulate cell growth, metabolism, and survival response to various stresses, and act as a positive regulator of autophagy. The anti-oxidative and anti-aging roles of Sesn2 have been the focus of many recent studies. Read More

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http://dx.doi.org/10.14336/AD.2019.0320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961765PMC
February 2020

The Clinical Efficacy and Safety of Stem Cell Therapy for Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Aging Dis 2020 Feb 1;11(1):141-153. Epub 2020 Feb 1.

1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Diabetes mellitus (DM) is a chronic metabolic disease with high morbidity and mortality. Recently, stem cell-based therapy for DM has shown considerable promise. Here, we undertook a systematic review and meta-analysis of published clinical studies to evaluate the efficacy and safety of stem cell therapy for both type 1 DM (T1DM) and type 2 DM (T2DM). Read More

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http://dx.doi.org/10.14336/AD.2019.0421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961772PMC
February 2020

Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease.

Aging Dis 2020 Feb 1;11(1):129-140. Epub 2020 Feb 1.

6Department of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, China.

Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem associated with high morbidity and mortality, especially in elderly patients. Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, which are closely related to chronic inflammatory response and oxidation-antioxidant imbalance in the pathogenesis of COPD. COPD displays distinct inflammaging features, including increased cellular senescence and oxidative stress, stem cell exhaustion, alterations in the extracellular matrix, reduced levels of endogenous anti-inflammaging molecules, and reduced autophagy. Read More

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http://dx.doi.org/10.14336/AD.2019.0508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961773PMC
February 2020

Tumor-Derived Soluble MICA Obstructs the NKG2D Pathway to Restrain NK Cytotoxicity.

Aging Dis 2020 Feb 1;11(1):118-128. Epub 2020 Feb 1.

1Department of Immunology, Basic Medical School of Central South University, Changsha, Hunan, China.

The natural killer group 2D (NKG2D) receptor and its ligands play important roles in immune surveillance. In this study, we observed that the average serum soluble MICA (sMICA) concentration of 174 hepatocellular carcinoma (HCC) patients was significantly higher than that in 80 healthy subjects (602.17 ± 338. Read More

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http://dx.doi.org/10.14336/AD.2019.1017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961768PMC
February 2020