404,324 results match your criteria Aging Neuropsychology And Cognition[Journal]


Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois.

Background: Prostatic inflammation and various proinflammatory systemic comorbidities, such as diabetes and obesity are associated with human benign prostatic hyperplasia (BPH). There is a paucity of in vivo models reflecting specific aspects of BPH pathogenesis. Our aim was to investigate the nonobese diabetic (NOD) mouse as a potential model for subsequent intervention studies. Read More

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http://dx.doi.org/10.1002/pros.23809DOI Listing
April 2019
5 Reads

Selective effect of static stretching, concentric contractions, and a one-leg balance task on ankle motion sense in young and older adults.

Gait Posture 2019 Apr 10;71:1-6. Epub 2019 Apr 10.

Faculty of Sport, University of Ljubljana, Ljubljana, Slovenia.

Background: Being aware of ankle movement and motor control has a critical role in maintaining balance during functional activities such as standing, walking, and running. Since the somatosensory system declines with aging, this is even more important for older adults.

Research Question: How do different exercise modalities (static stretching, one-leg balance task, concentric contractions, and control) acutely influence ankle motion sense in young and older adults?

Methods: Seventeen young and fifteen older participants performed four different intervention protocols (static stretching, one-leg balance task, concentric contractions, and control) in random order. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.04.006DOI Listing

Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999-2002.

Psychoneuroendocrinology 2019 Apr 4;106:171-178. Epub 2019 Apr 4.

Department of Epidemiology, Columbia University Mailman School of Public Health, United States; Robert N. Butler Columbia Aging Center, Columbia University, United States. Electronic address:

Background: Biological processes of aging are thought to be modifiable causes of many different chronic diseases. Measures of biological aging could provide sensitive endpoints for studies of risk factors hypothesized to shorten healthy lifespan and/or interventions that extend it. But uncertainty remains about how to measure biological aging and if proposed measures assess the same thing. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.03.012DOI Listing

Association between self-reported hearing impairment, use of a hearing aid and performance of instrumental activities of daily living.

Arch Gerontol Geriatr 2019 Apr 6;83:101-105. Epub 2019 Apr 6.

Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia; Geriatric Epidemiology Research Department, Instituto Nacional De Geriatría, México City, Mexico; Geriatric Medicine Research Unit, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

Background And Purpose: Age-related hearing loss is a prevalent condition among the growing elderly population, which has been associated with both cognitive decline and decreased daily functioning. Decreased functioning is linked to lower performance, predominantly regarding instrumental activities of daily living (IADLs). The present study aims to explore the association between hearing loss and impairment in IADLs. Read More

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http://dx.doi.org/10.1016/j.archger.2019.04.001DOI Listing

Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Aging causes various functional changes, including cognitive impairment and inflammatory responses in the brain. Transient receptor potential melastatin 2 (TRPM2), a Ca-permeable channel expressed abundantly in immune cells, exacerbates inflammatory responses. Previously, we reported that TRPM2 on resident microglia plays a critical role in exacerbating inflammation, white matter injury, and cognitive impairment during chronic cerebral hypoperfusion; however, the physiological or pathophysiological role of TRPM2 during age-associated inflammatory responses remains unclear. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.012DOI Listing

Anti-atherogenic effects of CD36-targeted epigallocatechin gallate-loaded nanoparticles.

J Control Release 2019 Apr 15. Epub 2019 Apr 15.

Department of Nutritional Sciences, Texas Tech University, Lubbock, TX 79409, USA. Electronic address:

Intimal macrophages play a critical role in atherosclerotic lesion initiation and progression by taking up oxidized low-density lipoprotein (oxLDL) and promoting inflammatory process. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine (KOdiA-PC), a major type of oxidized phosphatidylcholines (PC) found on oxLDL, has a high binding affinity to the macrophage scavenger receptor CD36 and participates in CD36-mediated recognition and uptake of oxLDL by intimal macrophages. We successfully synthesized epigallocatechin gallate (EGCG)-loaded nanoparticles (Enano), which were composed of EGCG, PC, (+) alpha-tocopherol acetate, and surfactant. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193021
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http://dx.doi.org/10.1016/j.jconrel.2019.04.018DOI Listing
April 2019
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Effect of benzalkonium chloride on dentin bond strength and endogenous enzymatic activity.

J Dent 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, 40125 Bologna, Italy. Electronic address:

Objective: This in vitro study evaluated at baseline (T0) and over time (T12 months), the effect of a multi-mode universal adhesive compared with two experimental formulations blended with different concentrations of benzalkonium chloride (BAC), on bond strength and endogenous enzymatic activity.

Methods And Materials: Specimens were assigned to the following groups according to the adhesive protocol: G1) All-Bond Universal (ABU) self-etch (SE); G2) ABU + 0.5% BAC SE; G3) ABU + 1% methacrylate BAC SE; G4) ABU etch-and-rinse (E&R); G5) ABU + 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03005712193006
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http://dx.doi.org/10.1016/j.jdent.2019.04.008DOI Listing
April 2019
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Fate and transformation of graphene oxide in estuarine and marine waters.

Environ Sci Technol 2019 Apr 18. Epub 2019 Apr 18.

The possibility of graphene oxide (GO) exposure to the environment has spurred several studies investigating the fate of this nanoparticle (NP). However, there is currently little or no data on the fate of GO in estuarine and marine waters. This study investigated the aggregation, sedimentation and transformation of GO in saline waters, considering the role of salinity (0-50 ‰), light (visible light and solar irradiation), aging, among others. Read More

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http://dx.doi.org/10.1021/acs.est.8b06485DOI Listing

Hearing Aid Prevalence and Factors Related to Use Among Older Adults From the Hispanic Community Health Study/Study of Latinos.

JAMA Otolaryngol Head Neck Surg 2019 Apr 18. Epub 2019 Apr 18.

National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

Importance: Hearing loss is highly prevalent in the rapidly growing and aging Hispanic/Latino population in the United States. However, little is known or understood about hearing aid use among US adults from Hispanic/Latino backgrounds.

Objective: To describe hearing aid prevalence and factors associated with hearing aid use among US adults of Hispanic/Latino backgrounds. Read More

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http://dx.doi.org/10.1001/jamaoto.2019.0433DOI Listing

Comparison of the 18-item and 6-item Lubben Social Network Scales with community-dwelling older adults in Mongolia.

PLoS One 2019 18;14(4):e0215523. Epub 2019 Apr 18.

Wayne State University, Detroit, Michigan, United States of America.

This study compares the psychometric properties of two versions of the Lubben Social Network Scale (LSNS-18 and LSNS-6) with community dwelling older adults in Mongolia. We recruited 650 older adult in the capital city of Ulaanbaatar and the country's four rural regions. We used the Geriatric Depression Scale (GDS-15), the Short Form 12 (SF-12) physical and mental health functioning measures, and a multi-dimensional scale of social isolation for confirmatory factor analyses of the LSNS-18 and the LSNS-6. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215523PLOS

Variability in the validity and reliability of outcome measures identified in a systematic review to assess treatment efficacy of cognitive enhancers for Alzheimer's Dementia.

PLoS One 2019 18;14(4):e0215225. Epub 2019 Apr 18.

Institute for Health Policy, Management & Evaluation, University of Toronto, Toronto, Ontario Canada.

Introduction: Selection of optimal outcome measures is a critical step in a systematic review; inclusion of uncommon or non-validated outcome measures can impact the uptake of systematic review findings. Our goals were to identify the validity and reliability of outcome measures used in primary studies to assess cognition, function, behaviour and global status; and, to use these data to select outcomes for a systematic review (SR) on treatment efficacy of cognitive enhancers for Alzheimer's Dementia (AD).

Methods: Articles fulfilling the eligibility criteria of the SR were included in a charting exercise to catalogue outcome measures reported. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215225PLOS
April 2019
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Effects of row direction and row spacing on maize leaf senescence.

PLoS One 2019 18;14(4):e0215330. Epub 2019 Apr 18.

Northeast Institute of Geography and Agroecology, CAS, Changchun, China.

To analyze three row orientations (south-north, east-west, southwestern 20°) and two row spacings ('65 + 65', '160 + 40'), we investigated the effect of row orientation and planting pattern on photosynthetic performance, physiological and biochemical indicators related to the aging of leaves. Results revealed that during maturity stage, in north-south and east-west, the initial fluorescence (Fo) at '65 + 65' were higher than those under'160 + 40'; the maximum quantum yield of PS2 photochemistry(ΦP0), basal quantum yield of non-photochemical processes in PS2(ΦN0)of the lower leaves and photosynthetic rate of the upper and ear leaves under'160 + 40'were higher than those under'65 + 65'. The polyphenoloxidase (POD) activities of leaves at different positions under '160 + 40' were higher than that under'65 + 65', while the malondialdehyde (MDA) content was lower. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215330PLOS
April 2019
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Pain Provocation and the Energy Cost of Walking: A Matched Comparison Study of Older Adults With and Without Chronic Low Back Pain With Radiculopathy.

J Geriatr Phys Ther 2019 Apr 15. Epub 2019 Apr 15.

Department of Physical Therapy, University of Delaware, Newark.

Background And Purpose: Chronic low back pain with radiculopathy (CLBPR) is common among older adults and can lead to walking difficulty. Energy cost of walking strongly predicts changes in walking speed, which is predictive of mortality in older adults. The purposes of this study were to examine (1) the impact of pain provocation on the energy cost of walking and (2) the relationship between pain intensity and change in energy cost of walking. Read More

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http://dx.doi.org/10.1519/JPT.0000000000000212DOI Listing
April 2019
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The Panacea of Human Aging: Calorie Restriction Versus Exercise.

Exerc Sport Sci Rev 2019 Apr 15. Epub 2019 Apr 15.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808.

Primary aging is the progressive decline in health and fitness and depends on metabolic rate and oxidative stress. Untoward changes in body composition and metabolic function characterizes secondary aging. We hypothesize that both exercise and calorie restriction improve secondary aging, but only calorie restriction improves primary. Read More

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http://Insights.ovid.com/crossref?an=00003677-900000000-9974
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http://dx.doi.org/10.1249/JES.0000000000000193DOI Listing
April 2019
1 Read

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B.

JCI Insight 2019 Apr 18;5. Epub 2019 Apr 18.

The bone marrow microenvironment (BMME) contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction of aged marrow macrophages (Mφs) directs HSC platelet-bias. Mφs from the marrow of aged mice and humans exhibited an activated phenotype, with increased expression of inflammatory signals. Read More

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http://dx.doi.org/10.1172/jci.insight.124213DOI Listing

Identification of noncoding RNA expression profiles and regulatory interaction networks following traumatic spinal cord injury by sequence analysis.

Aging (Albany NY) 2019 04 18. Epub 2019 Apr 18.

Jinan Central Hospital Affiliated to Shandong University, Jinan, China.

Aim: To systematically profile and characterize the noncoding RNA (ncRNA) expression pattern in the lesion epicenter of spinal tissues after traumatic spinal cord injury (TSCI) and predicted the structure and potential functions of the regulatory networks associated with these differentially expressed ncRNAs and mRNAs.

Results: A total of 498 circRNAs, 458 lncRNAs, 155 miRNAs and 1203 mRNAs were identified in TSCI mice models to be differentially expressed. The regulatory networks associated with these differentially expressed ncRNAs and mRNAs were constructed. Read More

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http://dx.doi.org/10.18632/aging.101919DOI Listing

Feasibility and outcomes: Pilot Randomized Controlled Trial of a home-based integrated physical exercise and bladder-training program vs usual care for community-dwelling older women with urinary incontinence.

Neurourol Urodyn 2019 Apr 18. Epub 2019 Apr 18.

Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.

Aims: To assess the feasibility of a randomized controlled trial of a home-based integrated physical exercise and bladder-training program vs usual care in community-dwelling women with urinary incontinence (UI).

Methods: We conducted a parallel arm, nonblinded, pilot randomized controlled trial of a home-based integrated physical exercise and bladder training with urge suppression and fall prevention program (ExerciseUP) vs usual care in women aged 65 and older with UI. Outcomes included feasibility (process, resources, management, and acceptability), urinary symptoms, and falls risk using self-administered questionnaires. Read More

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http://dx.doi.org/10.1002/nau.23999DOI Listing

Efficient and Stable CsPbI Solar Cells via Regulating Lattice Distortion with Surface Organic Terminal Groups.

Adv Mater 2019 Apr 18:e1900605. Epub 2019 Apr 18.

State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, China.

All-inorganic cesium lead iodide perovskites (CsPbI ) are promising wide-bandgap materials for use in the perovskite/silicon tandem solar cells, but they easily undergo a phase transition from a cubic black phase to an orthorhombic yellow phase under ambient conditions. It is shown that this phase transition is triggered by moisture that causes distortion of the corner-sharing octahedral framework ([PbI ] ). Here, a novel strategy to suppress the octahedral tilting of [PbI ] units in cubic CsPbI by systematically controlling the steric hindrance of surface organic terminal groups is provided. Read More

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http://dx.doi.org/10.1002/adma.201900605DOI Listing

[Bioinformatics Analysis and Verification of Aging-Related Genes of Bone Marrow Mesenchymal Stem Cells in Patients with Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):311-317

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China,E-mail:

Objective: To screen and verify the differentially expressed genes related with aging of bone marrow mesenchymal stem cells (BM-MSCs) in acute myeloid leukemia (AML) patients by bioinformatics, so as to provide new molecular markers for the research and clinical treatment of AML.

Methods: The gene expression profiling chip related with BM-MSCs in AML patients in our hospital and the gene chip GSE84881 selected from NCBI database GEO were used for data analysis and exploration. The DAVID analysis software was used to perform gene ontology (GO) enrichment analysis and KEGG pathway enrichment analysis. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.001DOI Listing

Arterial stiffness relates to executive dysfunction in later life.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 Apr 18:1-12. Epub 2019 Apr 18.

a The Healthy Brain Ageing Clinic, School of Psychology , The University of Sydney , Camperdown , NSW , Australia.

Cardiovascular disease in older people is often linked with cognitive impairment, particularly in domains of executive function and processing speed. Our aims examined whether carotid-femoral pulse wave velocity (PWV) related to subtle changes of executive function and processing speed. Fifty-six individuals with subjective mood and/or cognitive concerns underwent PWV and neuropsychological assessments of processing speed (Trail Making Test Part A) and executive functioning (Delis Kaplan Executive Function System Stroop Task; Trail Making Test Part B, TMT-B). Read More

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https://www.tandfonline.com/doi/full/10.1080/13825585.2019.1
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http://dx.doi.org/10.1080/13825585.2019.1597009DOI Listing
April 2019
1 Read

Evidence against preserved syntactic comprehension in healthy aging.

J Exp Psychol Learn Mem Cogn 2019 Apr 18. Epub 2019 Apr 18.

School of Psychology.

We investigated age-related differences in syntactic comprehension in young and older adults. Most previous research found no evidence of age-related decline in syntactic processing. We investigated elementary syntactic comprehension of minimal sentences (e. Read More

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http://dx.doi.org/10.1037/xlm0000707DOI Listing

Largely Enhancing Luminous Efficacy, Color-Conversion Efficiency, and Stability for Quantum Dot White LEDs Using the Two-dimensional Hexagonal Pore Structure of SBA-15 Mesoporous Particles.

ACS Appl Mater Interfaces 2019 Apr 18. Epub 2019 Apr 18.

Quantum dots (QDs) white light-emitting diodes (LEDs) are promising in illumination and display applications due to the excellent color quality. Although they have a high quantum yield closed to unity, the reabsorption of QD light leads to high conversion loss, significantly reducing the luminous efficacy and stability of QD white LEDs. In this report, SBA-15 mesoporous particles (MPs) with two-dimensional hexagonal pore structures (2D-HPS) are utilized to largely enhance the luminous efficacy and color-conversion efficiency of QD white LEDs in excess of 50%. Read More

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http://dx.doi.org/10.1021/acsami.8b22298DOI Listing

Loss of Posterior Occluding Teeth and Its Association with Protein-Micronutrients Intake and Muscle Mass among Thai Elders: A Pilot Study.

J Frailty Aging 2019 ;8(2):100-103

Dunyaporn Trachootham, Institute of Nutrition, Mahidol University, 999 Phutthamonthon Sai 4 Road, Salaya, Nakhon Pathom, Thailand, 73170. E-mail: Tel.: (66) 2 800 2380 ext.326; fax: (66) 2 441 9344.

Contact between upper and lower posterior teeth is crucial for chewing. However, the influence of posterior occluding teeth loss on protein intake and muscle mass was unclear. This cross-sectional study compared consumption frequency of protein food, amount of protein and relevant micronutrient intakes and muscle mass indices among older adults with different Eichner indices (EI) of posterior occluding teeth loss. Read More

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http://dx.doi.org/10.14283/jfa.2019.2DOI Listing
January 2019

Economic Impact of Hospitalizations in US Adults with Sarcopenia.

J Frailty Aging 2019 ;8(2):93-99

Suzette Pereira, Abbott- Nutrition Division, Research and Development, 3300 Stelzer Road, Columbus, OH 43219 Phone: +1 614-624-4625, Fax: 614-727-4625, Email:

Background: Sarcopenia is characterized by progressive loss of muscle mass with corresponding decline in strength and/or physical function. The economic burden of sarcopenia-associated disability is considerable in the US.

Objective: To estimate the cost of hospitalizations in US adults with sarcopenia categorized by age, sex, and race/ethnicity. Read More

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http://www.jfrailtyaging.com/all-issues.html?article=721
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http://dx.doi.org/10.14283/jfa.2019.10DOI Listing
January 2019
1 Read

Age of HIV Acquisition Affects the Risk of Multi-Morbidity after 25 Years of Infection Exposure.

J Frailty Aging 2019 ;8(2):88-92

Giovanni Guaraldi, Universita degli Studi di Modena e Reggio Emilia, Italy,

Introduction: Understanding the intersection of HIV, aging and health is crucial due to the increasing number of people aging with HIV.

Objective: The objective of the study was to assess the prevalence of, and risk factors for individual comorbidities and multi-morbidity in people living with HIV with similar duration of HIV infection, notwithstanding a 25-year difference at the time of HIV acquisition.

Methods: In a cross-sectional multicentre retrospective study, we compared three match-control age groups. Read More

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http://www.jfrailtyaging.com/all-issues.html?article=713
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http://dx.doi.org/10.14283/jfa.2019.6DOI Listing
January 2019
1 Read

Predictive Ability of Seven Domains of the Kihon Checklist for Incident Dependency and Mortality.

J Frailty Aging 2019 ;8(2):85-87

Shosuke Satake, Section of Frailty Prevention, Department of Frailty Research, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430, Morioka-cho, Obu, Aichi 474-8511, Japan, Phone: +81-562-46-2311, FAX: +81-562-44-8518, e-mail address:

The Kihon Checklist (KCL) is a structured questionnaire consisting of 7 domains to assess seniors' function in daily living. The aim of this study was to examine which domains of the KCL can predict incident dependency and mortality. The municipality sent a KCL questionnaire to independent seniors in Higashi-ura Town and collected the answers of the 5542 seniors who provided complete answers. Read More

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http://www.jfrailtyaging.com/all-issues.html?article=712
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http://dx.doi.org/10.14283/jfa.2019.3DOI Listing
January 2019
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An Ultrasound Prediction Equation to Estimate DXA-Derived Body Fatness for Middle-Aged and Older Caucasian Adults.

J Frailty Aging 2019 ;8(2):79-84

Takashi Abe, PhD, 224 Turner Center, University, MS 38677, USA, Phone: +1 (662) 915-5521, Fax: +1 (662) 915-5525, Email:

Background And Objectives: Currently, only one study has used dual-energy X-ray absorptiometry (DXA)-derived percent body fat (BF%) as the criterion measure to develop ultrasound prediction equations to estimate BF% in adults between the ages of 50 and 80 years. The aim of this study was to examine the relationship between BF% estimated from subcutaneous fat thickness using a previously published Japanese-based prediction equation and DXA-derived BF% in Caucasian middle-aged and older adults. A secondary aim was to develop a new prediction equation for Caucasian adults if the previously published equation did not predict BF% well in Caucasians. Read More

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http://www.jfrailtyaging.com/all-issues.html?article=718
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http://dx.doi.org/10.14283/jfa.2019.8DOI Listing
January 2019
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Psoas and Paraspinous Muscle Measurements on Computed Tomography Predict Mortality in European Americans with Type 2 Diabetes Mellitus.

J Frailty Aging 2019 ;8(2):72-78

Barry I. Freedman, MD, Internal Medicine - Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, Phone: 336-716-6461, Fax: 336-716-4318,

Background: Appendicular skeletal muscle mass index and muscle attenuation (density) are negatively associated with mortality in European-derived populations.

Objectives: The present analyses assessed association between axial skeletal muscle density and muscle index with mortality in European Americans with type 2 diabetes mellitus (T2D).

Design: Single-center observational study. Read More

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http://dx.doi.org/10.14283/jfa.2019.5DOI Listing
January 2019

Defining Frailty in Research Abstracts: A Systematic Review and Recommendations for Standardization.

J Frailty Aging 2019 ;8(2):67-71

Ariela R. Orkaby, MD MPH, Instructor in Medicine, Harvard Medical School, Geriatric Research, Education and Clinical Center, VA Boston Healthcare System, 150 South Huntington St, Boston, MA 02130 USA, Phone: 857-364-3646; Fax: 857-364-2784, Email:

Multiple definitions of frailty are used. We sought to quantify the frequency that frailty is insufficiently defined in published abstracts. We conducted a systematic review of MEDLINE/PubMed for English abstracts of original research investigating frailty as an exposure or outcome in humans from 2015-2017. Read More

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http://dx.doi.org/10.14283/jfa.2019.4DOI Listing
January 2019

The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults.

J Frailty Aging 2019 ;8(2):62-66

Mathieu Maltais, PhD, Gérontopôle de Toulouse, Institut du Vieillissement, Bâtiment B, 37 Allée Jules Guesde, 31000, Toulouse France, +33 6 74 70 63 71, E-mail :

Background/objectives: Apolipoprotein (ApoE ε4) status has been associated with various cardiovascular diseases and Alzheimer's Disease. Some studies have found a possible relationship between the presence of an ApoE ε4 allele and the decrease of motor function in healthy older adults. The objective of this study was to measure the cross-sectional and prospective associations of ApoE ε4 status with lower limb function and handgrip strength in older adults. Read More

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http://dx.doi.org/10.14283/jfa.2019.7DOI Listing
January 2019

Longitudinal Changes in Muscle Mass and Function in Older Men at Increased Risk for Sarcopenia - The FrOST-Study.

J Frailty Aging 2019 ;8(2):57-61

Professor Dr. Wolfgang Kemmler, Institute of Medical Physics, Friedrich-Alexander University Erlangen-Nürnberg, Henkestrasse 91 91052 Erlangen, Germany, Tel: 0049 9131-8523999, Fax: 0049 9131-8522824, Email:

Background: Declines in muscle mass and function are inevitable developments of the advanced aging process. Corresponding dimensions of longitudinal changes in at-risk populations are still scarce although clinically relevant. The present study monitored changes in morphologic and functional sarcopenia criteria related to sarcopenia in older men with low muscle mass over a period of 24 months. Read More

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http://dx.doi.org/10.14283/jfa.2019.9DOI Listing
January 2019

The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore.

J Frailty Aging 2019 ;8(2):54-56

Cristina Gussago, PhD, Department of Medical Sciences and Community Health, Università degli Studi di Milano, Via Pace 9, 20122 Milan, Italy phone: +39 0255035405, fax:+39 0250320735, email:

Alzheimer's disease (AD) is a common neurodegenerative disorder, strongly related with age. It has been reported that genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2), a cell-surface receptor expressed in microglial cells, greatly increase the risk of AD, thus suggesting an involvement of the microglia in the AD pathogenesis. The aim of this report is to provide an overview of the TREM2 and of its possible implication in the pathogenesis of AD. Read More

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http://dx.doi.org/10.14283/jfa.2018.43DOI Listing
January 2019
2 Reads

Bisexual Lives and Aging in Context: A Cross-National Comparison of the United Kingdom and the United States.

Int J Aging Hum Dev 2019 Apr 18:91415019843661. Epub 2019 Apr 18.

2 The Open University, Milton Keynes, UK.

Research on bisexual histories and identities in later life is limited and reflects only single-nation studies. This article compares findings from two independently conducted studies of bisexual aging, in the United Kingdom and the United States, using a discourse analytic and life course perspective. The goals were to compare how participants narrated and made sense of their bisexual experiences in later life and to examine ways in which historical and cultural contexts shaped their accounts. Read More

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http://dx.doi.org/10.1177/0091415019843661DOI Listing

Later Life Care Planning and Concerns of Transgender Older Adults in Canada.

Int J Aging Hum Dev 2019 Apr 18:91415019843520. Epub 2019 Apr 18.

3 San Francisco State University, CA, USA.

While the particular health-care concerns of transgender people have been documented and transgender aging is an emerging area of scholarship, little is known about planning for later and end-of-life care among transgender older adults. As part of a larger project, focus groups and interviews were conducted with 24 transgender older adults (average age 70 years) living in five cities in Canada exploring their concerns and explicit plans for later life care. Three primary themes emerged: (a) "dealing with the day-to-day" reflecting economic precarity and transitioning in later life, (b) fractures and support within family and community, and (c) "there's a huge gap between principle and practice" reflecting mixed experiences and perceptions of health-care services. Read More

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http://journals.sagepub.com/doi/10.1177/0091415019843520
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http://dx.doi.org/10.1177/0091415019843520DOI Listing
April 2019
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Demographic and Psychosocial Predictors of Housing Security in Older Lesbian and Gay Australians.

Int J Aging Hum Dev 2019 Apr 18:91415019843449. Epub 2019 Apr 18.

8 COTA Australia, Canberra, Australia.

This study examined housing security among 679 lesbian women and gay men aged 60 years and older living in Australia. We examined a range of potential demographic and psychosocial predictors of whether participants felt that their housing situation was secure. Overall, most participants (89%) felt that their housing situation was secure. Read More

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http://dx.doi.org/10.1177/0091415019843449DOI Listing

Life Satisfaction and Depression in the Oldest Old: A Longitudinal Study.

Int J Aging Hum Dev 2019 Apr 18:91415019843448. Epub 2019 Apr 18.

3 Department of Social Welfare, Dong-Eui University, Busan, South Korea.

This study aimed to analyze the effect of individual differences and family variables on life satisfaction and depression in the oldest old compared with the young-old. A total of 1,799 cases from an 8-year period of the Korean Welfare Panel Study (2006-2013) were analyzed. A key finding was that life satisfaction significantly increased with time for the two groups of older adults while depression decreased. Read More

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http://dx.doi.org/10.1177/0091415019843448DOI Listing
April 2019
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Perceptions on Use of the Subjective Global Assessment Before and After It Became Part of Regular Practice.

Nutr Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Nutrition & Aging Lab, Schlegel-UW Research Institute for Aging, Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.

Background: Subjective global assessment (SGA) is a standardized diagnostic tool for malnutrition and identifies those who would benefit from nutrition treatment. SGA has been validated in several patient populations; however, implementation in clinical practice is inconsistent. The objective of this study was to understand and contrast the perceptions on use of SGA before and after it became a regular practice for hospital dietitians. Read More

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http://dx.doi.org/10.1002/ncp.10270DOI Listing

Inflammatory biomarkers and frailty among older hospitalized patients: author's response.

Aging Clin Exp Res 2019 Apr 17. Epub 2019 Apr 17.

National Clinical Research Center for Geriatrics, Chengdu, China.

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http://dx.doi.org/10.1007/s40520-019-01198-3DOI Listing

The association between preoperative fatigue and instrumental activities in daily living with complications and length of hospital stay in patients undergoing colorectal surgery.

Aging Clin Exp Res 2019 Apr 17. Epub 2019 Apr 17.

ACHIEVE Center for Applied Research, University of Applied Sciences Amsterdam, Amsterdam, The Netherlands.

Background: The incidence of colorectal cancer (CRC) is highest among the elderly. An important treatment modality is surgery. After surgery, due to poor functional recovery, some elderly have an increased risk for complications and prolonged length of hospital stay (LOS). Read More

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http://dx.doi.org/10.1007/s40520-019-01199-2DOI Listing

Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina.

Mol Neurobiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by electron microscopy and immunocytochemistry. We also tested cultured Müller glia for their response to S1P. Read More

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http://dx.doi.org/10.1007/s12035-019-1599-xDOI Listing

Optimal Facelift Vector and its Relation to Zygomaticus Major Orientation.

Aesthet Surg J 2019 Apr 11. Epub 2019 Apr 11.

Private facial plastic surgery practice in New York, NY.

Background: The vector of SMAS redraping in rhytidectomy is often described in relation to the zygomaticus major muscle, so that suspension prevents distortion of the mimetic musculature and a "facelifted appearance." There is no data describing the true orientation of this muscle in the midface.

Objective: Define the vector of the zygomaticus major muscle relative to the Frankfort horizontal plane. Read More

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https://academic.oup.com/asj/advance-article/doi/10.1093/asj
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http://dx.doi.org/10.1093/asj/sjz114DOI Listing
April 2019
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Estrogen-deficient skin: The role of topical therapy.

Int J Womens Dermatol 2019 Jun 15;5(2):85-90. Epub 2019 Mar 15.

Montefiore Medical Center, Department of Medicine, Division of Dermatology, Bronx, New York.

Menopause is a major turning point in a woman's life that is characterized by declining ovarian function and decreased serum estrogen levels. The resulting hormonal changes particularly affect the skin, with postmenopausal symptoms such as loss of structural architecture and increased propensity to damage becoming rapidly noticeable. Interestingly, studies have shown that estrogen deprivation in postmenopausal conditions accelerates many skin changes, including dryness, atrophy, fine wrinkling, and poor wound healing. Read More

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http://dx.doi.org/10.1016/j.ijwd.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451761PMC

Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.

ACS Med Chem Lett 2019 Apr 25;10(4):545-551. Epub 2019 Feb 25.

Department of Pharmacy, "Drug Discovery" Laboratory, University of Napoli "Federico II", Via D. Montesano, 49, 80131 Napoli, Italy.

The development of PPARα/γ dual or PPARα/γ/δ pan-agonists could represent an efficacious approach for a simultaneous pharmacological intervention on carbohydrate and lipid metabolism. Two series of new phenyldiazenyl fibrate derivatives of GL479, a previously reported PPARα/γ dual agonist, were synthesized and tested. Compound was identified as a PPAR pan-agonist with moderate and balanced activity on the three PPAR isoforms (α, γ, δ). Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466826PMC

Effect of winemaking on phenolic profile, colour components and antioxidants in (sin. ) wine.

J Food Sci Technol 2019 Apr 20;56(4):1841-1853. Epub 2019 Feb 20.

1Department of Food Technology and Biotechnology, Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, Croatia.

or is a Croatian autochthonous grape variety which is a parent of the America's most popular variety or Italian . The aim of this study was to investigate the dynamics of extraction of phenolics and changes in antioxidant activity of the samples collected during maceration of grapes processed using two different macerating enzymes. According to the obtained results it can be concluded that wines from grapes are great source of bioactive phenolics although differences in phenolic profiles between control and enzyme-treated wines were detected. Read More

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http://link.springer.com/10.1007/s13197-019-03638-4
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http://dx.doi.org/10.1007/s13197-019-03638-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443773PMC
April 2019
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Comparison of multi-tissue aging between human and mouse.

Sci Rep 2019 Apr 17;9(1):6220. Epub 2019 Apr 17.

Geneis (Beijing) Co. Ltd, Beijing, 100102, P. R. China.

With the rapid growth of the aging population, exploring the biological basis of aging and related molecular mechanisms has become an important topic in modern scientific research. Aging can cause multiple organ function attenuations, leading to the occurrence and development of various age-related metabolic, nervous system, and cardiovascular diseases. In addition, aging is closely related to the occurrence and development of tumors. Read More

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http://www.nature.com/articles/s41598-019-42485-3
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http://dx.doi.org/10.1038/s41598-019-42485-3DOI Listing
April 2019
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The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration.

Nat Commun 2019 Apr 17;10(1):1796. Epub 2019 Apr 17.

Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, 10901N Torrey Pines Road, La Jolla, CA, 92037, USA.

Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation. However, the mechanisms that promote mitochondrial respiration during stem cell differentiation are poorly understood. Here we demonstrate that Stat3 promotes muscle stem cell myogenic lineage progression by stimulating mitochondrial respiration in mice. Read More

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http://dx.doi.org/10.1038/s41467-019-09746-1DOI Listing

The acute transcriptional response to resistance exercise: impact of age and contraction mode.

Aging (Albany NY) 2019 Apr;11(7):2111-2126

Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, UK.

Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. Read More

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http://dx.doi.org/10.18632/101904DOI Listing
April 2019
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A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair.

Aging (Albany NY) 2019 Apr 17. Epub 2019 Apr 17.

Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.

Nuclear architecture plays a significant role in DNA repair mechanisms. It is evident that proteins involved in DNA repair are compartmentalized in not only spontaneously occurring DNA lesions or ionizing radiation-induced foci (IRIF), but a specific clustering of these proteins can also be observed within the whole cell nucleus. For example, 53BP1-positive and BRCA1-positive DNA repair foci decorate chromocenters and can appear close to nuclear speckles. Read More

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http://dx.doi.org/10.18632/aging.101917DOI Listing

The roles of sirtuin 1 and its activator, resveratrol in osteoarthritis.

Biosci Rep 2019 Apr 17. Epub 2019 Apr 17.

Xiangya Hospital, Central South University, Changsha, China.

Osteoarthitis (OA) is the most common aging-related joint pathology; the aging process results in changes to joint tissues that ultimately contribute to the development of OA. Articular chondrocytes exhibit an aging-related decline in their proliferative and synthetic capacity. Sirtuin 1 (SIRT 1), a longevity gene related to many diseases associated with aging, is a NAD+-dependent protein deacetylase and master metabolic regulator. Read More

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http://dx.doi.org/10.1042/BSR20190189DOI Listing

Human kallikrein overexpression alleviates cardiac aging by alternatively regulating macrophage polarization in aged rats.

FASEB J 2019 Apr 17:fj201802371RR. Epub 2019 Apr 17.

Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cardiac aging is characterized by myocardial hypertrophy, fibrosis, and diastolic dysfunction. Human kallikrein (hKLK1) protects against fibrosis in various pathogenic states. However, the effects of hKLK1 overexpression on cardiac aging-related fibrosis and the underlying mechanisms remain unknown. Read More

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http://dx.doi.org/10.1096/fj.201802371RRDOI Listing