433,921 results match your criteria Aging Milan Italy[Journal]


Juxtacrine signaling via Notch and ErbB receptors in the switch to fate commitment of bone marrow-derived Schwann cells.

Eur J Neurosci 2020 May 27. Epub 2020 May 27.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, Hong Kong.

The phenotypic instability of adult tissue-derived Schwann cell-like cells (SCLCs) as revealed upon withdrawal of glia-inducing culture supplements limits their clinical utility for cell therapy and disease modelling. We previously overcame this limitation by co-culturing bone marrow-derived SCLCs with neurons purified from developing rat and subsequently human sensory neurons such that direct contact between cell types accomplished the cell-intrinsic switch to the Schwann cell fate. Here, our search for juxtacrine instructive signals found both Notch ligands and neuregulin-1 type III localized on the surface of DRG neurons via live-cell immunocytochemistry. Read More

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http://dx.doi.org/10.1111/ejn.14837DOI Listing

Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress.

Prostate 2020 May 27. Epub 2020 May 27.

Department of Structural and Functional Biology, Institute of Biology, University of Campinas, São Paulo, Brazil.

Background: Brazilian berry is a fruit popularly known as "Jaboticaba," rich in bioactive compounds with antioxidant and anti-inflammatory properties. Senescence and overweight are increasing worldwide and are considered risk factors to prostatic pathogenesis mainly due to oxidative and inflammatory processes induction. Thus, this study aimed to evaluate the effect of two increasing doses of the patented jaboticaba peel extract (PJE) on oxidative-stress and inflammation in the prostate of aging or high-fat-fed aging mice. Read More

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http://dx.doi.org/10.1002/pros.24017DOI Listing

Is There an Association Between Self-Reported Physical Activity and Self-Rated Vision Over Time? Results From the Irish Longitudinal Study of Ageing.

J Aging Phys Act 2020 May 22:1-8. Epub 2020 May 22.

Research suggests that physical activity (PA) has many health benefits for an aging population. Evidence exploring the association between PA and vision is limited. This study includes the measures of self-reported PA (International Physical Activity Questionnaire) and self-rated vision at three points in time over a 6-year period used in the Irish Longitudinal study of Ageing, a cohort of community-dwelling older adults (50 years or older). Read More

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http://dx.doi.org/10.1123/japa.2019-0371DOI Listing

Muscle strength is related to mental and physical quality of life in the oldest old.

Arch Gerontol Geriatr 2020 May 15;89:104109. Epub 2020 May 15.

Department of Aging, Neurological, Orthopaedic and Head-Neck Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore di Roma, Rome, Italy.

Purpose Of The Study: Quality of life represents the principal outcome of health interventions for the oldest old. However, little is known about the determinants of quality of life in this population stratum. We evaluated the association between health-related quality of life (HRQoL) and handgrip strength in a cohort of 331 participants aged 90+ with a living in the Mugello area (Tuscany, Italy). Read More

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http://dx.doi.org/10.1016/j.archger.2020.104109DOI Listing

Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination.

Cell Rep 2020 May;31(8):107686

Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto 860-0811, Japan. Electronic address:

Meiotic recombination is critical for genetic exchange and generation of chiasmata that ensures faithful chromosome segregation during meiosis I. Meiotic recombination is initiated by DNA double-strand break (DSB) followed by multiple processes of DNA repair. The exact mechanisms for how recombinases localize to DSB remain elusive. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107686DOI Listing

A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging.

Cell Rep 2020 May;31(8):107694

Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore. Electronic address:

Aging is an inevitable process that involves profound physiological changes. Long non-coding RNAs (lncRNAs) are emerging as important regulators in various biological processes but are not systemically studied in aging. To provide an organism-wide lncRNA landscape during aging, we conduct comprehensive RNA sequencing (RNA-seq) analyses across the mouse lifespan. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107694DOI Listing

Interfacial Stability in BiTe Thermoelectric Joints.

ACS Appl Mater Interfaces 2020 May 27. Epub 2020 May 27.

Bismuth-telluride (BiTe) based thermoelectric materials are well known for their high figure-of-merit (zT value) in the low-temperature region. Stable joints in the module are essential for creating a reliable device for long-term applications. This paper used electroless Co-P to prevent a severe interfacial reaction between the joints of solder and BiTe. Read More

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http://dx.doi.org/10.1021/acsami.9b22853DOI Listing

Corrigendum.

Authors:

Aging Cell 2020 May;19(5):e13165

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http://dx.doi.org/10.1111/acel.13165DOI Listing

Intrinsic Luminescence from Nonaromatic Biomolecules.

Chempluschem 2020 May;85(5):1065-1080

School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Lab of Electrical Insulation and Thermal Aging, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai, 200240, P. R. China.

Novel emitters that do not contain traditional chromophores but only electron-rich moieties (e. g. amine, C=O, -OH, ether, and imide), which are classified as nonconventional luminophores, have been more frequently reported. Read More

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http://dx.doi.org/10.1002/cplu.202000021DOI Listing

Pharmacokinetic Comparison of Capsule and Tablet Formulations of Opicapone in Healthy Japanese Subjects: Phase 1 Study.

Clin Pharmacol Drug Dev 2020 May 27. Epub 2020 May 27.

Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Opicapone, a peripheral, long-acting catechol-O-methyltransferase inhibitor has been shown to improve wearing-off phenomenon in randomized, double-blind studies. This study compared the pharmacokinetic characteristics of opicapone small-tablet and size 1 capsule formulations after single oral administration to healthy Japanese subjects. In this open-label, randomized, 2-way and 2-period crossover phase 1 study, 48 healthy male subjects (aged 20 to 45 years; body mass index, 18. Read More

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http://dx.doi.org/10.1002/cpdd.802DOI Listing

Numerical working memory alters alpha-beta oscillations and connectivity in the parietal cortices.

Hum Brain Mapp 2020 May 27. Epub 2020 May 27.

Center for Magnetoencephalography, University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA.

Although the neural bases of numerical processing and memory have been extensively studied, much remains to be elucidated concerning the spectral and temporal dynamics surrounding these important cognitive processes. To further this understanding, we employed a novel numerical working memory paradigm in 28 young, healthy adults who underwent magnetoencephalography (MEG). The resulting data were examined in the time-frequency domain prior to image reconstruction using a beamformer. Read More

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http://dx.doi.org/10.1002/hbm.25043DOI Listing

Aging-related increase of cGMP disrupts mitochondrial homeostasis in Leydig cells.

J Gerontol A Biol Sci Med Sci 2020 May 27. Epub 2020 May 27.

Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.

Since mitochondria play an essential role in the testosterone biosynthesis, serve as power centers and are a source of oxidative stress, a possible mitochondrial dysfunction could be connected with decreased activity of Leydig cells and lowered testosterone production during aging. Here we chronologically analyzed age-related alterations of mitochondrial function in Leydig cells correlated by the progressive rise of cGMP-signaling and with respect to testosterone synthesis. To target cGMP-signaling in Leydig cells, acute or long-term in vivo or ex vivo treatments with sildenafil (PDE5 inhibitor) were performed. Read More

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http://dx.doi.org/10.1093/gerona/glaa132DOI Listing

Systematic Review and Meta-Analysis on the Associations of Polypharmacy and Potentially Inappropriate Medication with Adverse Outcomes in Older Cancer Patients.

J Gerontol A Biol Sci Med Sci 2020 May 27. Epub 2020 May 27.

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background: Both polypharmacy and potentially inappropriate medication (PIM) intake are highly prevailing in older cancer patients. However, only studies on the association of polypharmacy and post-operative complications have been meta-analyzed previously.

Methods: A systematic review and a meta-analysis of prospective/retrospective observational studies reporting associations of polypharmacy or PIM with at least 1 out of 5 pre-defined adverse health outcomes in a population of older cancer patients (≥ 60 years) were carried out. Read More

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http://dx.doi.org/10.1093/gerona/glaa128DOI Listing

Topoisomerase II-binding protein 1 promotes the progression of prostate cancer via ATR-CHK1 signaling pathway.

Aging (Albany NY) 2020 May 27;12. Epub 2020 May 27.

Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

DNA damage response (DDR) plays an important role in the progression of cancers, including prostate cancer (PCa). Topoisomerase II-binding protein 1 (TopBP1) is an essential promotor of ATR-mediated DDR. Herein, we investigated the association between TopBP1 and PCa and determined its effect on the progression of PCa. Read More

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http://dx.doi.org/10.18632/aging.103260DOI Listing

Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53.

Aging (Albany NY) 2020 May 27;12. Epub 2020 May 27.

Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.

Although osteoporosis is one of the most common chronic age-related diseases, there is currently no gold standard for treatment. Evidence suggests resveratrol, a natural polyphenolic compound, may be helpful in the treatment of osteoporosis and other diseases. However, the molecular mechanisms underlying the anti-osteoporotic effects of resveratrol remain largely unknown. Read More

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http://dx.doi.org/10.18632/aging.103262DOI Listing

Mobile Personal Healthcare System for Non-Invasive, Pervasive and Continuous Blood Pressure Monitoring: A Feasibility Study.

JMIR Mhealth Uhealth 2020 Apr 26. Epub 2020 Apr 26.

Departments of Neurosciences and Human Genetics, and Rio Grande Valley Alzheimer´s Disease Resource Center for Minority Aging Research, University of Texas Rio Grande Valley, Brownsville, US.

Background: Smartphone-based blood pressure (BP) monitor using photoplethysmogram (PPG) technology has emerged as a promising approach to empower users with self-monitoring for effective diagnosis and control of hypertension (HT).

Objective: This study aimed to develop a mobile personal healthcare system for non-invasive, pervasive, and continuous estimation of BP level and variability to be user-friendly to elderly.

Methods: The proposed approach was integrated by a self-designed cuffless, calibration-free, wireless and wearable PPG-only sensor, and a native purposely-designed smartphone application using multilayer perceptron machine learning techniques from raw signals. Read More

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http://dx.doi.org/10.2196/18012DOI Listing

Why is the explicit component of motor adaptation limited in elderly adults?

J Neurophysiol 2020 May 27. Epub 2020 May 27.

KU Leuven, Belgium.

The cognitive component of motor adaptation declines with aging. Yet, in other motor tasks, older adults appear to rely on cognition to improve their motor performance. It is unknown why older adults are not able to do so in motor adaptation. Read More

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http://dx.doi.org/10.1152/jn.00659.2019DOI Listing

Glucose-induced duration-dependent genome-wide DNA methylation changes in human endothelial cells.

Am J Physiol Cell Physiol 2020 May 27. Epub 2020 May 27.

Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.

DNA methylation, a critical epigenetic mechanism, plays an important role in governing gene expressions during biological processes such as aging, which is well known to be accelerated in hyperglycemia (diabetes). In the present study, we investigated the effects of glucose on whole-genome DNA methylation in small (HRECs) and large (HUVECs) vessel endothelial cell (EC) lines exposed to basal or high glucose-containing media for variable lengths of time. Using the Infinium EPIC array, we obtained 773,133 CpG sites (probes) for analysis. Read More

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http://dx.doi.org/10.1152/ajpcell.00011.2020DOI Listing

How Geographical Isolation and Aging in Place Can Be Accommodated Through Connected Health Stakeholder Management: Qualitative Study With Focus Groups.

J Med Internet Res 2020 May 27;22(5):e15976. Epub 2020 May 27.

Nanjing Audit University, Naijing, China.

Background: In remote areas, connected health (CH) is needed, but as local resources are often scarce and the purchasing power of residents is usually poor, it is a challenge to apply CH in these settings. In this study, CH is defended as a technological solution for reshaping the direction of health care to be more proactive, preventive, and precisely targeted-and thus, more effective.

Objective: The objective of this study was to explore the identity of CH stakeholders in remote areas of Taiwan and their interests and power in order to determine ideal strategies for applying CH. Read More

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http://dx.doi.org/10.2196/15976DOI Listing

VX-765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke-induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway.

CNS Neurosci Ther 2020 May 27. Epub 2020 May 27.

Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Introduction: To investigate the protective effect of VX-765 on human umbilical mesenchymal stem cells (HUMSCs) in stroke and its mechanism.

Materials And Methods: Mouse models of ischemic stroke were established using the distal middle cerebral artery occlusion (dMCAO) method. The dMCAO mice were accordingly transplanted with HUMSCs, VX-765-treated HUMSCs, or VX-765 + MHY185-treated HUMSCs. Read More

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http://dx.doi.org/10.1111/cns.13400DOI Listing

Assessing frailty in heart failure.

Eur J Heart Fail 2020 May 27. Epub 2020 May 27.

Heart Failure Unit, Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

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http://dx.doi.org/10.1002/ejhf.1905DOI Listing

[Health determinants in irregular migrants with chronic diseases: analysis of the accesses to the clinic of a non-governmental organization].

Assist Inferm Ric 2020 Jan-Mar;39(1):13-23

. Health determinants in irregular migrants with chronic diseases: analysis of the accesses to the clinic of a non-governmental organization.

Introduction: Of the 112 thousand irregular migrants in Lombardy, 49 thousand reside in the area of Milan. Read More

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http://dx.doi.org/10.1702/3371.33472DOI Listing

Using Community-Based Participatory Research Strategies in Age-Friendly Communities to Solve Mobility Challenges.

J Gerontol Soc Work 2020 May 27:1-17. Epub 2020 May 27.

Age-Friendly Communities, Columbus and Franklin County, College of Social Work, The Ohio State University , Columbus, Ohio, USA.

The number of older adults is steadily increasing in the United States and across the globe. Aging is linked to an increased risk of disability. Disabilities that limit one or more major life activities such as seeing, hearing, walking, and motor skills impact a person's ability to drive a car. Read More

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http://dx.doi.org/10.1080/01634372.2020.1769787DOI Listing

Social Work Response Needed to the Challenge of COVID-19 for Aging People with Intellectual and Developmental Disabilties.

Authors:
Philip McCallion

J Gerontol Soc Work 2020 May 27:1-3. Epub 2020 May 27.

School of Social Work, College of Public Health, Temple University , Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1080/01634372.2020.1769791DOI Listing

Brain Network Measures for Groups of Nodes: Application to Normal Aging and Alzheimer's Disease.

Brain Connect 2020 May 27. Epub 2020 May 27.

University of Jaffna - Vavuniya Campus, 119006, Faculty of Applied Science, Vavuniya Campus of the University of Jaffna, Vavuniya, Sri Lanka, 43000;

Background: The nodal brain network measures (e.g. centrality measures) are defined for a single node and the global network measures (e. Read More

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http://dx.doi.org/10.1089/brain.2020.0747DOI Listing

GLOBAL Leukemia in Children 0-14 Statistics 2018, Incidence and Mortality and Human Development Index (HDI): GLOBOCAN Sources and Methods.

Asian Pac J Cancer Prev 2020 May 1;21(5):1487-1494. Epub 2020 May 1.

Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Objective: Cancer is the second leading cause of death in children under 15 and leukemia is the most common type of cancer in this age group.  The aim of the present study is to investigate the incidence and mortality of leukemia in children aged 0-14 years and its relationship with Human Development Index (HDI in different countries of the world.  Methods: Incidence and mortality rates were obtained from GLOBOCAN and Country's income from World Bank. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1487DOI Listing

Clinical Value of NOTCH1 Mutations Detection among Chronic Lymphocytic Leukemia Patients.

Asian Pac J Cancer Prev 2020 May 1;21(5):1295-1301. Epub 2020 May 1.

Hematology Unit, Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura University, Egypt.

Background: The data about the clinical impact of NOTCH1 mutations among Egyptians B - cell chronic lymphocytic patients is not previously identified. We herein, evaluate the prevalence and the prognostic significance of neurogenic locus notch homolog protein-1 (NOTCH1) mutations in B- cell lymphocytic leukemia (B-CLL).

Methods: A cohort of 105 Egyptian B-CLL patients aging from 43 to 86 years. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1295DOI Listing

Ethanol Extract of Hizikia fusiforme Induces Apoptosis in B16F10 Mouse Melanoma Cells through ROS-Dependent Inhibition of the PI3K/Akt Signaling Pathway.

Asian Pac J Cancer Prev 2020 May 1;21(5):1275-1282. Epub 2020 May 1.

Anti-Aging Research Center, Dong-eui University, Busan 47340, Republic of Korea.

Background: Previous studies have reported that Hizikia fusiforme, an edible brown seaweed, has diverse health-promoting effects; however, evidence for its anti-cancer potential is still lacking. In this study, we examined the effect of ethanol extract of H. fusiforme (EHF) on the proliferation of B16F10 mouse melanoma cells. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1275DOI Listing

MRI-Related Heating of Implants and Devices: A Review.

J Magn Reson Imaging 2020 May 26. Epub 2020 May 26.

Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.

During an MRI scan, the radiofrequency field from the scanner's transmit coil, but also the switched gradient fields, induce currents in any conductive object in the bore. This makes any metallic medical implant an additional risk for an MRI patient, because those currents can heat up the surrounding tissues to dangerous levels. This is one of the reasons why implants are, until today, considered a contraindication for MRI; for example, by scanner manufacturers. Read More

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http://dx.doi.org/10.1002/jmri.27194DOI Listing

Left atrial stiffness in women with ischemia and no obstructive coronary artery disease: Novel insight from left atrial feature tracking.

Clin Cardiol 2020 May 27. Epub 2020 May 27.

Department of Kinesiology, University of Texas, Arlington, Texas, USA.

Background: Women with signs and symptoms of ischemia and no obstructive coronary artery disease (INOCA) are at risk of heart failure with preserved ejection fraction (HFpEF); however, the mechanism for HFpEF progression remains unclear. Studies in INOCA have largely focused on left ventricular function. The left atrium serves an important role in maintaining transmitral flow, and is impaired in HFpEF; however, it remains unclear if left atrial function is impaired in INOCA. Read More

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http://dx.doi.org/10.1002/clc.23395DOI Listing

Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice.

Neurotox Res 2020 May 26. Epub 2020 May 26.

Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA.

Recent pre-clinical and clinical studies suggest that general anesthesia in infants and children may increase the risk of learning disabilities. Currently, there is no treatment for preventing anesthesia-induced neurotoxicity and potential long-term functional impairment. Animal studies have shown that neonatal exposure to anesthesia can induce acute neurotoxicity and long-term behavioral changes that can be detected a few months later. Read More

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http://dx.doi.org/10.1007/s12640-020-00223-yDOI Listing

Spatial-dependent regularization to solve the inverse problem in electromyometrial imaging.

Authors:
Hui Wang Yong Wang

Med Biol Eng Comput 2020 May 26. Epub 2020 May 26.

Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Recently, electromyometrial imaging (EMMI) was developed to non-invasively image uterine contractions in three dimensions. EMMI collects body surface electromyography (EMG) measurements and uses patient-specific body-uterus geometry generated from magnetic resonance images to reconstruct uterine electrical activity. Currently, EMMI uses the zero-order Tikhonov method with mean composite residual and smoothing operator (CRESO) to stabilize the underlying ill-posed inverse computation. Read More

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http://dx.doi.org/10.1007/s11517-020-02183-zDOI Listing

[Vitamin D in geriatric patients].

Internist (Berl) 2020 May 26. Epub 2020 May 26.

Klinik für Geriatrie, Universitätsspital Zürich, Rämistraße 100, 8091, Zürich, Schweiz.

Vitamin D deficiency is widespread in geriatric patients. While vitamin D deficiency is prevalent in about 50% of healthy older adults, the prevalence in geriatric patients with hip fracture increases to over 80%. This is partly due to the fact that sunlight is unreliable as the main source of vitamin D. Read More

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http://dx.doi.org/10.1007/s00108-020-00803-2DOI Listing

Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer's Disease.

CNS Drugs 2020 May 26. Epub 2020 May 26.

Department of Microbiology and Infectious diseases, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada.

Alzheimer's disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that the cause of AD is senile plaque formation by the amyloid β peptide, and the formation of neurofibrillary tangles by hyperphosphorylated tau. Read More

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http://dx.doi.org/10.1007/s40263-020-00737-1DOI Listing

The association between polypharmacy and the efficiency of the functional independence measure in an acute-stage hospital: a retrospective cohort study.

Aging Clin Exp Res 2020 May 26. Epub 2020 May 26.

Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1196, Japan.

Background: The Functional Independence Measure (FIM) evaluates the activities of daily living (ADL), and FIM efficiency represents daily improvement in FIM. Polypharmacy affects both ADL and FIM; however, few studies have evaluated its relationship with FIM efficiency.

Aim: This retrospective study investigated the effect of polypharmacy on FIM efficiency in patients undergoing rehabilitation at our acute care hospital in 2014. Read More

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http://dx.doi.org/10.1007/s40520-020-01591-3DOI Listing

Clinicians' and public acceptability of universal risk-of-death screening for older people in routine clinical practice in Australia: cross-sectional surveys.

Aging Clin Exp Res 2020 May 26. Epub 2020 May 26.

Gold Coast Hospital and Health Service, Professorial Unit Level 2, PED Building E, 1 Hospital Boulevard, Southport, QLD, 4215, Australia.

Background: Clinicians' delays to identify risk of death and communicate it to patients nearing the end of life contribute to health-related harm in health services worldwide. This study sought to ascertain doctors, nurses and senior members of the public's perceptions of the routine use of a screening tool to predict risk of death for older people.

Methods: Cross-sectional online, face-to-face and postal survey of 360 clinicians and 497 members of the public. Read More

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http://dx.doi.org/10.1007/s40520-020-01598-wDOI Listing

The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing.

Aging Clin Exp Res 2020 May 26. Epub 2020 May 26.

Upjohn (Division of Pfizer), Surrey, UK.

The early stages of the COVID-19 pandemic have focused on containing SARS-CoV-2 infection and identifying treatment strategies. While controlling this communicable disease is of utmost importance, the long-term effect on individuals with non-communicable diseases (NCD) is significant. Although certain NCDs appear to increase the severity of COVID-19 and mortality risk, SARS-CoV-2 infection in survivors with NCDs may also affect the progression of their pre-existing clinical conditions. Read More

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http://dx.doi.org/10.1007/s40520-020-01601-4DOI Listing

Live cell imaging and proteomic profiling of endogenous NEAT1 lncRNA by CRISPR/Cas9-mediated knock-in.

Protein Cell 2020 May 26. Epub 2020 May 26.

Sun Yat-sen Memorial Hospital, Sun Yat-sen University; MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.

In mammalian cells, long noncoding RNAs (lncRNAs) form complexes with proteins to execute various biological functions such as gene transcription, RNA processing and other signaling activities. However, methods to track endogenous lncRNA dynamics in live cells and screen for lncRNA interacting proteins are limited. Here, we report the development of CERTIS (CRISPR-mediated Endogenous lncRNA Tracking and Immunoprecipitation System) to visualize and isolate endogenous lncRNA, by precisely inserting a 24-repeat MS2 tag into the distal end of lncRNA locus through the CRISPR/Cas9 technology. Read More

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http://dx.doi.org/10.1007/s13238-020-00706-wDOI Listing

Effects of curcumin on neurological diseases: focus on astrocytes.

Pharmacol Rep 2020 May 27. Epub 2020 May 27.

Halal Research Center of IRI, FDA, Tehran, Iran.

Astrocytes are the most abundant glial cells in the central nervous system, and are important players in both brain injury and neurodegenerative disease. Curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione), the major active component of turmeric, belongs to the curcuminoid family that was originally isolated from the plant Curcuma longa. Several studies suggest that curcumin may have a beneficial impact on the brain pathology and aging. Read More

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http://dx.doi.org/10.1007/s43440-020-00112-3DOI Listing

Impact of Age on Multiple Sclerosis Disease Activity and Progression.

Curr Neurol Neurosci Rep 2020 May 26;20(7):24. Epub 2020 May 26.

Department of Neurology, Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.

Purpose Of Review: The purpose of this review is to discuss the interaction between aging, progressive disease course, disability worsening, and treatment strategies in multiple sclerosis (MS).

Recent Findings: The transition from the relapsing-remitting phase to the progressive phase in MS often happens in the fifth decade. In MS, structural central nervous system reserve decreases with aging and MS-associated mechanisms. Read More

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http://dx.doi.org/10.1007/s11910-020-01046-2DOI Listing

A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.

Geroscience 2020 May 26. Epub 2020 May 26.

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.

Dopaminergic nigrostriatal denervation and widespread intracellular α-synuclein accumulation are neuropathologic hallmarks of Parkinson's disease (PD). A constellation of peripheral processes, including metabolic and inflammatory changes, are thought to contribute to neurodegeneration. In the present study, we sought to obtain insight into the multifaceted pathophysiology of PD through the application of a multi-marker discovery approach. Read More

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http://dx.doi.org/10.1007/s11357-020-00192-2DOI Listing

Evaluation of Residual Neuro-Muscular Integrity in the Orbicularis Oculi Muscle After Lower Eyelid Transcutaneous Blepharoplasty According to Reidy Adamson-s Flap.

Aesthetic Plast Surg 2020 May 26. Epub 2020 May 26.

Plastic and Reconstructive Microsurgery, Careggi University Hospital, Viale Giacomo Matteotti 42, 50132, Florence, Italy.

Background: The aging process affects skin, muscle and fat of the eyes in a different manner. Their individual rejuvenation would require specific surgical treatment according to their particular demands during lower eyelid blepharoplasty. This would require the separate management of the skin and the muscle by separating them into two different flaps. Read More

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http://dx.doi.org/10.1007/s00266-020-01783-2DOI Listing

Dietary plant and animal protein intake and decline in estimated glomerular filtration rate among elderly women: a 10-year longitudinal cohort study.

Nephrol Dial Transplant 2020 May 26. Epub 2020 May 26.

Centre for Kidney Research, Children's Hospital at Westmead, School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia.

Background: Many older women demonstrate an age-related accelerating rate of renal decline that is associated with increased rates of bone disease, cardiovascular disease and mortality. Population-based protein restriction has been studied principally in patients with reduced renal function. In this investigation, we examined the hypothesis of a differential effect of plant-derived protein compared with animal-derived protein on renal function in older women. Read More

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http://dx.doi.org/10.1093/ndt/gfaa081DOI Listing

The Structure of Self-Regulation and Its Psychological and Physical Health Correlates in Older Adults.

Collabra Psychol 2020 15;6(1). Epub 2020 Apr 15.

Department of Psychology, University of Kentucky, Lexington, KY, US.

Self-regulation refers to effortful control over one's thoughts, emotions, choices, impulses, and behaviors, and has implications for older adults' health. Executive function, physiological, and subjective indices have all been proposed to reflect self-regulation. Pairwise associations among these indices have been previously examined; however, a self-regulation constellation encompassing all of these indices has never been tested in older adults. Read More

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http://dx.doi.org/10.1525/collabra.297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250393PMC

Review on the Role of Epigenetic Modifications in Doxorubicin-Induced Cardiotoxicity.

Front Cardiovasc Med 2020 7;7:56. Epub 2020 May 7.

Department of Biomedical Sciences, National Chung Cheng University, Chiayi, Taiwan.

Use of anthracyclines such as doxorubicin (DOX), for the treatment of cancer, is known to induce cardiotoxicity, begetting numerous evaluations of this adverse effect. This review emphasizes the mechanism of how consideration of DOX-induced cardiotoxicity is important for the development of cardioprotective agents. As DOX is involved in mitochondrial dysfunction, enzymes involved in epigenetic modifications that use mitochondrial metabolite as substrate are most likely to be affected. Read More

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http://dx.doi.org/10.3389/fcvm.2020.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221144PMC

PCDH7 Inhibits the Formation of Homotypic Cell-in-Cell Structure.

Front Cell Dev Biol 2020 8;8:329. Epub 2020 May 8.

Laboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.

Though homotypic cell-in-cell (hoCIC) structures are implicated in the development and progression of multiple human tumors, the molecular mechanisms underlying their formation remain poorly understood. We found that the expression of Protocadherin-7 (PCDH7), an integral membrane protein, was negatively associated with the formation of hoCIC structures. Overexpression of efficiently inhibits, while its depletion significantly enhances, hoCIC formation, which was attributed to its regulation on intercellular adhesion and contractile actomyosin as well. Read More

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http://dx.doi.org/10.3389/fcell.2020.00329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225324PMC

Pattern Recognition Receptor Ligands as an Emerging Therapeutic Agent for Latent HIV-1 Infection.

Front Cell Infect Microbiol 2020 8;10:216. Epub 2020 May 8.

Laboratory of Immunosenescence, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.

Toll-like receptors (TLRs) were first identified as molecular sensors that transduce signals from specific structural patterns derived from pathogens; their underlying molecular mechanisms of recognition and signal transduction are well-understood. To date, more than 20 pattern-recognition receptors (PRRs) have been reported in humans, some of which are membrane-bound, similar to TLRs, whereas others are cytosolic, including retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), and stimulator of interferon genes (STING). Clinically, PRR ligands have been developed as vaccine adjuvants to activate innate immunity and enhance subsequent antigen-specific immune responses. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225283PMC

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death.

Front Oncol 2020 7;10:723. Epub 2020 May 7.

Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco, Monaco.

Cancer cells are characterized as highly proliferative at the expense of enhancement of metabolic rate. Consequently, cancer cells rely on antioxidant defenses to overcome the associated increased production of reactive oxygen species (ROS). The reliance of tumor metabolism on amino acids, especially amino acid transport systems, has been extensively studied over the past decade. Read More

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http://dx.doi.org/10.3389/fonc.2020.00723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221143PMC

The lethal sex gap: COVID-19.

Immun Ageing 2020 21;17:13. Epub 2020 May 21.

4The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030 USA.

While Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is disrupting lives across the globe for everyone, it has a more devastating impact on the health of older adults, especially that of older men. This pandemic has highlighted the crucial importance of considering an individual's age and biological sex in the clinic in addition to other confounding diseases (Kuchel, G.A, J Am Geriatr Soc, 67, 203, 2019, Tannenbaum, C. Read More

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http://dx.doi.org/10.1186/s12979-020-00183-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240166PMC

Generation and Regeneration of Thymic Epithelial Cells.

Front Immunol 2020 7;11:858. Epub 2020 May 7.

Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.

The thymus is unique in its ability to support the maturation of phenotypically and functionally distinct T cell sub-lineages. Through its combined production of MHC-restricted conventional CD4 and CD8, and Foxp3 regulatory T cells, as well as non-conventional CD1d-restricted iNKT cells and invariant γδT cells, the thymus represents an important orchestrator of immune system development and control. It is now clear that thymus function is largely determined by the availability of stromal microenvironments. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221188PMC