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Aging Male 2022 Dec;25(1):145-155

Department of Urology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.

Objectives: Postprostatectomy urinary incontinence (PPUI) is a serious complication despite surgical advances. Treatment options for PPUI include conservative care like Pelvic floor muscle exercise (PFME), which is a physiotherapy performed by the patients themselves; Pelvic floor muscle therapy (PFMT), a physiotherapy performed under the guidance of a therapist, and duloxetine treatment; and surgical interventions. In this study, network meta-analysis (NMA) was performed for direct comparison of these treatment options. Read More

Aging Male 2022 Dec;25(1):134-144

Clinical and Surgical Andrology, Universitatsklinikum Munster Centrum fur Reproduktionsmedizin und Andrologie, Munster, Germany.

Context: Testosterone (T) therapy of hypogonadal men requires stable kinetics, tolerance and attenuation of symptoms. Both intramuscular injections of the long-acting ester T undecanoate (TU) and transdermal application of T gel offer a proven efficacy. As T has marked effects on hematopoiesis, an elevation of hematocrit has to be considered during T therapy. Read More

Aging Male 2022 Dec;25(1):125-133

Department of Microbiology and Parasitology, Hanoi Medical University's Hospital, Hanoi, Vietnam.

Objective: To explore the microbial etiology of urethritis in Vietnamese men and the association with patients' characteristics, especially their sexual behaviors.

Methods: This study was conducted on 349 men who presented with symptomatic urethritis and evidence of STIs (determined by multiplex PCR tests) at the Department of Andrology and Sexual Medicine-Hanoi Medical University Hospital. All information regarding medical history, sexual activities, and symptoms of urethritis was documented. Read More

Aging Male 2022 Dec;25(1):101-124

Department of Psychiatry, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Despite the effectiveness of androgen deprivation therapy in advanced prostate cancer, serious neuropsychiatric consequences in androgen deprivation therapy (ADT)-treated patients, mainly depression, have been concerning and gained more attention recently. This narrative review aims to shed light on the risk and pharmacological management of ADT-induced depression in PCa patients. We searched PubMed, Scopus and Google Scholar databases using MESH keywords "Prostate cancer OR prostate neoplasm" AND "Depression" AND "Androgen Deprivation Therapy" AND "antidepressants". Read More

Aging Male 2022 Dec;25(1):41-53

Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Background: Data about classification of hypogonadism and estrogen deficiency in male people living with HIV (PLWH) are scanty.

Aim: To investigate the prevalence and characterization of biochemical hypogonadism and relative estrogen deficiency in male PLWH aged < 50 comparing liquid chromatography-tandem mass spectrometry (LC-MS/MS) with chemiluminescent immunoassay (CI), and combining gonadotropin, sex hormone-binding globulin (SHBG) and serum estradiol (E2) measurements.

Methods: Prospective, cross-sectional, observational study. Read More

Aging Male 2022 Dec;25(1):72-87

Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt.

Background: Pathogenesis and endothelial function in subclinical hypogonadism (SCH) remain unclear. Undercarboxylated osteocalcin (ucOC) participates in atherosclerosis and reproduction. We explored the underlying mechanisms and interplay of endothelial dysfunction, unOC and reproductive hormones in SCH and primary late-onset hypogonadism (LOH). Read More

Aging Male 2022 Dec;25(1):88-93

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Objective: To investigate the relationship between histological prostatitis (HP) and clinical parameters related to benign prostatic hyperplasia (BPH) in male.

Method: The clinical data of 196 BPH patients who underwent transurethral resection of the prostate were collected. According to the results of hematoxylin-eosin (H&E) staining of prostate tissue, patients were divided into two groups: BPH with HP group and BPH without HP group. Read More

Aging Male 2022 Dec;25(1):65-71

Department of Medicine, Unit of Endocrinology and Metabolism, ASST Spedali Civili, Brescia, Italy.

Objective: To investigate whether routine assessment of free testosterone improves the diagnostic accuracy of functional hypogonadism.

Methods: Total and free testosterone (calculated on SHBG levels) were determined in 188 patients with sexual symptoms and 184 with infertility.

Results: Hypogonadism (calculated free testosterone <63 pg/ml) was found in 47/188 (25. Read More

Aging Male 2022 Dec;25(1):60-64

Department of Chemical Sciences, University of Catania, Catania, Italy.

Aging Male 2022 Dec;25(1):54-61

Prostate Center Northwest, Department of Urology, Paediatric Urology and Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.

Objective: The aim of this study was to evaluate the prognostic impact of concomitant prostate cancer (PCa) of the cancer-specific mortality (CSM) in the aging patient's papulation with bladder cancer (BCa) treated with radical cystoprostatectomy (RCP).

Materials And Methods: Within the SEER database (2004-2015), 1468 patients were treated with RCP for BCa harboring histopathological PCa findings. To account for other cause mortality (OCM), multivariable competing risk regression (CRR) tested for potential BCa-CSM differences according to PCa characteristics risk factors predicting CSM. Read More

Aging Male 2022 Dec;25(1):62-66

Department of Urology, Medical University of Vienna, Vienna, Austria.

Objectives: To investigate the correlation between lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and testosterone deficiency (TD) with depressive, stress, and anxiety symptoms.

Material And Methods: From October 2019 to March 2020, 113 males were included. Inclusion criteria: age 40-75, no clinical suspicion of prostate cancer, no serious cardiovascular comorbidities. Read More

Aging Male 2022 Dec;25(1):29-40

Max Planck Institute for Demographic Research, Rostock, Germany.

The literature on testosterone (T) in men reports diverse correlates of T, some with minimal empirical support and most with little indication of how they change with advancing age. We test eight putative correlations across age. Correlations were tested on a large sample of British men. Read More

Aging Male 2022 Dec;25(1):23-28

Department of Surgery, Division of Urology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Purpose: Multiparametric magnetic resonance imaging (mpMRI) targeted biopsy has emerged as an augmentation to systematic prostate biopsy (SBx) with improved diagnostic accuracy. The purpose of this study was to determine whether biopsy modality impacted management of prostate cancer (PCa).

Methods: We performed a retrospective review of patients with newly diagnosed non-metastatic PCa at our institution (2014-2020). Read More

Aging Male 2022 Dec;25(1):17-22

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

We aimed to evaluate the impact of seminal low-risk human Papillomavirus (LR-HPV) infection on sperm conventional parameters. This was a retrospective case-control study including patients attending to our center for infertility. Patients with evidence for high risk (HR)-HPV infection previously or at the time of enrollment, and/or with severe oligozoospermia (sperm concentration <5 mil/ml) were ruled out. Read More

Aging Male 2022 Dec;25(1):8-16

Department of Urology, Pediatric Urology and Uro-Oncology, Prostate Center Northwest, St. Antonius-Hospital, Gronau, Germany.

Objectives: The aim of this study was to assess whether age ≥75 years impairs surgical, functional, and oncological outcomes after robot-assisted radical prostatectomy (RARP).

Materials And Methods: Patients with prostate cancer (PCa) were stratified in ≥75( = 669) vs. <70 years( = 8,268). Read More

Aging Male 2022 Dec;25(1):1-7

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Objective: To investigate the associations of impaired muscle strength and gait function with the severity of erectile dysfunction (ED) in men undergoing dialysis.

Methods: This cross-sectional study included 63 men undergoing dialysis. ED was assessed with the Sexual Health Inventory for Men (SHIM). Read More

Aging Male 2021 Dec;24(1):160-170

Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, PR China.

Objective: This study aims to evaluate the overall efficacy and safety between holmium laser enucleation of the prostate (HoLEP) and bipolar transurethral enucleation of the prostate (B-TUEP) for the treatment of benign prostatic hyperplasia (BPH).

Method: We systematically searched electronic databases (PubMed, Scopus, Web of Science, and Cochrane Library) to identify eligible comparative studies as of July 2021. The parameters including perioperative results, complications, and functional outcomes were evaluated. Read More

Aging Male 2021 Dec;24(1):80-91

Department of Urology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Background: Our study was conducted to investigate the effect of 5-ARI on the death rate from prostate cancer by means of an updated meta-analysis using related data.

Methods: We did comprehensive literature searches using the PubMed, Embase, and Cochrane databases through July 2019. We evaluated the risk of bias in such studies using the ROBINS-I tool and analyzed deaths from cancer and deaths from all causes using HR. Read More

Aging Male 2021 Dec;24(1):58-71

Department of Endocrinology and Metabolism, the First Hospital of Jilin University, Changchun, PR China.

Purpose: Liquid biopsy refers to the detection and analysis of the components from biological fluids non-invasively, including circulating tumor cells, nucleic acids, and extracellular vesicles (EVs). It is necessary to review the clinical value of liquid biopsy assays in PC and explore its potential application.

Materials And Methods: We systematically reviewed of PubMed was performed to identify relevant literature on potential clinical applications of circulating tumor cells, circulating nucleic acids, and EVs in prostate cancer (PC). Read More

Aging Male 2021 Dec;24(1):148-159

Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, China.

Background: Currently, China has an increasingly aging population. However, the prevalence of metabolic syndrome (MetS) in this high-risk population for metabolic diseases remains unknown. This study investigates the age- and gender-specific prevalence and associated factors of MetS in the middle-aged and elderly Chinese population. Read More

Aging Male 2021 Dec;24(1):139-147

Department of Physiology and Pathology, Araraquara School of Dentistry, University of São Paulo State, UNESP, Araraquara, Brazil.

This study aimed to evaluate the effect of physiological testosterone replacement on male aged rats with orchiectomy-induced osteoporosis in advanced stage. Thirty male rats (, Holtzman lineage) were randomly distributed into 3 groups ( = 10): 1-sham, 2-orchiectomy (OCX), 3-OCX + testosterone replacement (OCX + T). On day 0, a sham or orchiectomy surgery was performed according to the groups. Read More

Aging Male 2021 Dec;24(1):119-138

Department of Urology, Harvard Medical School, Boston, MA, USA.

The relative proportional increase of the elderly population within many countries will become one of the most significant social transformations of the twenty-first century and, for the first time in history, persons aged 65 or above outnumbered children under five years of age globally. One in four persons living in Europe and Northern America will be aged 65 or over. One of the goals of ISSAM is to raise awareness of the special health needs of older men. Read More

Aging Male 2021 Dec;24(1):106-118

Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Background: Testosterone is associated with sexual desire and performance in men, but little is known about cognitive mechanisms underlying this relationship. Even less is known about the influence of estradiol, despite its production from testosterone, and high receptor density in brain regions related to male sexual behavior.

Method: We used eye-tracking to compare men's visual attention to images of fully clothed (i. Read More

Aging Male 2021 Dec;24(1):37-41

Department of Urology, Sultan Abdulhamid Han Education and Research Hospital, Istanbul, Turkey.

Objective: This study aims to analyze the challenges, approaches and long-term results of primary or metachronous prostate cancer (PCa) in cases with multiple primary genitourinary cancers.

Methodology: A total of 17 patients were included in the study. Patients with multiple primary genitourinary cancers were divided into two groups according to the diagnosis of primary or metachronous PCa as group 1 and group 2. Read More

Aging Male 2021 Dec;24(1):101-105

Hamad General Hospital, Doha, Qatar.

Purpose: This controlled study assessed whether there was a correlation between serum total testosterone levels and bladder cancer (BCa) in terms of tumor grade and stage as objective measures in adult men.

Materials And Method: Our prospectively-designed study included 257 patients who were diagnosed with primary BCa and its surgery between January 2017 and January 2020. Hundred and forty patients who had surgery in the same period with TUR for prostate or endoscopic ureteral stone treatment were included in the study as a control group. Read More

Aging Male 2021 Dec;24(1):95-100

Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Secondary spinal cord changes can follow spinal cord injuries (SCIs). This retrospective study was to uncover the chronic secondary changes that affect the spinal cord following severe injuries and to evaluate the influence of residual spinal deformity in the development of posttraumatic spinal cord changes. Fifty-eight patients (39 male, 19 female) with complete traumatic SCI and recent Magnetic resonance imaging (MRI) follow-up were reviewed retrospectively. Read More

Aging Male 2021 Dec;24(1):92-94

Department of Urology, London North West University Healthcare NHS Trust, London, UK.

Digital rectal examination (DRE) is routinely performed as part of a urology clinical assessment in patients with a clinical suspicion of prostate cancer. An abnormal DRE or a raised prostate specific antigen (PSA) level are part of the criteria for primary care referral to secondary care due to a suspicion of prostate cancer. The current Coronavirus-19 (COVID-19) pandemic has resulted in the rapid adoption of virtual consultations in the form of telephone or video consultations making clinical examination difficult. Read More

Aging Male 2021 Dec;24(1):72-79

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, PR China.

Background: Inflammation is crucial in the pathogenesis of lower urinary tract symptoms (LUTS) in men. Diet modulates inflammation. Therefore, diet could be a modifiable factor in male LUTS prevention and treatment. Read More

Aging Male 2021 Dec;24(1):50-57

Department of Radiation Oncology, University of Health Science Prof. Dr. CemilTascioglu City Hospital, Istanbul, Turkey.

Background: We aimed to investigate the efficacy and tolerability of ultra-hypofractionated radiotherapy (UHRT) in the treatment of low and intermediate-risk prostate cancer patients.

Methods: This retrospective study was conducted using data derived from 44 patients who underwent UHRT, and toxicity assessment and clinical response were investigated. Treatment consisted of 35-36. Read More

Aging Male 2021 Dec;24(1):42-49

Department of Cardiology, İstanbul Kartal Koşuyolu Research and Training Hospital, İstanbul, Turkey.

Background: Erectile dysfunction (ED) is an early form of atherosclerosis and subclinical myocardial dysfunction. Epicardial fat tissue (EFT) is associated with impaired left ventricular (LV) function, even in the absence of cardiovascular disease. The aim of this study was to investigate the association between EFT and LV systolic function in patients with erectile ED by speckle tracking echocardiography (2D-STE) method. Read More