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Aging Male 2019 Apr 16:1-10. Epub 2019 Apr 16.

a Epidemiology and Cancer Prevention Division , Maria Skłodowska-Curie Institute - Oncology Center , Warsaw , Poland.

Background: During 2015 in Poland, male-to-female ratio in age-adjusted cancer mortality rate amounted to 1.83, which is close to that observed in 1990 (1.94) and considerably more than in 1965 (1. Read More

Aging Male 2019 Apr 11:1-11. Epub 2019 Apr 11.

a Department of Biomedicine and Biotechnology , University of Alcalá , Madrid , Spain.

Prostate cancer is one of the most common cancers in the male population. The objective of this investigation was to study the relationship of components of transforming growth factor-B (TGF-β)/phosphoinositide-3-kinases (PI3K)/AKT/mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-kB) transduction pathway with clinical-pathological markers. By immunohistochemical methods, we determined the expression of several factors [TGF-β, Transforming Growth Factor B Receptor I (TGFBRI), TGFBRII, PI3K, AKT-Ser, AKT-Thr, mTOR, p-mTOR, inhibitor kB kinase (IKK), pIKK, inhibitor kB (IkB), pIkB, NF-kBp50, and NF-kBp65]. Read More

Aging Male 2019 Apr 9:1-8. Epub 2019 Apr 9.

e Andrology Center , Coimbatore , India.

The diagnosis of sperm DNA integrity is increasingly recognized as being crucial to inform the clinical course in infertile couples. An internationally accepted sperm DNA fragmentation assay that determines the proportion of sperm and degree of broken sperm nuclear DNA with recognised clinical thresholds for identifying men at risk of infertility is the Sperm Chromatin Structure Assay (SCSA). In this study, SCSA test was utilised to evaluate the relevance of male age on sperm DNA quality in total of 6881 males of Indian origin. Read More

Aging Male 2019 Apr 9:1-6. Epub 2019 Apr 9.

a Department of Urology , Chonnam National University Medical School , Gwangju , Korea.

Purpose: In vitro evaluation of polycaprolactone (PCL) scaffolds fabricated by a three-dimensional (3D) printing technique for tissue engineering applications in the corpus cavernosum.

Materials And Methods: PCL scaffolds were fabricated by use of a 3 D bioprinting system. The 3D-printed scaffolds had interconnected structures for cell ingrowth. Read More

Aging Male 2019 Apr 6:1-10. Epub 2019 Apr 6.

c Department of Urology , St George's Hospital , London , UK.

Introduction: Erectile dysfunction is an established, well known risk of any operative management of benign prostatic hyperplasia (BPH). However, there are some cases reported in which surgical treatment has paradoxically improved erectile function. Here, we present a systematic review of the literature pertaining to the effect of surgery on sexual function, focusing on reports of improvement in erectile function following surgery. Read More

Aging Male 2019 Apr 6:1-8. Epub 2019 Apr 6.

a Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia , Universidad Tecnologica de Pereira-Audifarma S.A , Pereira , Colombia.

Background: Prostatic hyperplasia is frequent in the elderly, and it can be associated with urinary retention in patients who use cholinergic antagonists. The objective was to estimate the anticholinergic burden of drugs prescribed to patients diagnosed with benign prostatic hyperplasia.

Methods: A cross-sectional study using a population database to identify prescriptions of cholinergic antagonists drugs used in the management of benign prostatic hyperplasia. Read More

Aging Male 2019 Apr 4:1-5. Epub 2019 Apr 4.

a Department of Internal Medicine , Bolu Abant Izzet Baysal University Hospital , Bolu , Turkey.

In present study, we aimed to investigate anemia etiologies, underlying causes, laboratory markers of anemia, required interventions in postmenopausal women and elderly men. The medical data of the anemic subjects were recorded from the patients' files and computerized database of the institution and retrospectively analyzed. Study population grouped into two according to the gender; men and women. Read More

Aging Male 2019 Apr 4:1-8. Epub 2019 Apr 4.

a Department of Urology , Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung , Taiwan.

Purpose: Applying low-intensity extracorporeal shockwave therapy (LI-ESWT) has been reported to improve symptoms of refractory chronic pelvic pain syndrome (CPPS) in short-term follow-up. This study aims to demonstrate the effect of LI-ESWT on refractory CPPS over the span of a 12-month follow-up.

Materials And Methods: This was an open-label, single-arm prospective study. Read More

Aging Male 2019 Apr 3:1-6. Epub 2019 Apr 3.

a Department of Clinical and Experimental Medicine , University of Catania , Catania , Italy.

Objective: The aim of this article is to propose an algorithm that aids the clinician to choose the best therapeutic scheme of follicle-stimulating hormone (FSH) in the treatment of men with idiopathic infertility, based on testicular volume (TV) and serum total testosterone concentrations; highlighting the potential role of additional therapy with hCG in a sequential temporal scheme.

Materials And Methods: We subdivided patients in four clinical groups: patients with normal TV and serum testosterone concentrations (A); patients with normal TV and reduced serum testosterone concentrations (B); patients with reduced TV and serum testosterone concentration (C); patient with low TV e normal serum testosterone concentrations (D). Then, we administered to each group a specific therapeutic scheme. Read More

Aging Male 2019 Apr 3:1-8. Epub 2019 Apr 3.

e Department of Biochemistry , Yildirim Beyazit University Faculty of Medicine , Ankara , Turkey.

Aim: Obstructive sleep apnea syndrome (OSAS) is a chronic and incapacitating disease that often requires lifelong care. This study aimed to evaluate the thiol/disulfide homeostasis in patients with OSAS, to compare the thiol/disulfide levels with the control group and to investigate their relationship with the severity of the disease.

Material And Methods: Patients who were admitted to the department of chest diseases, and diagnosed with OSAS using polysomnographic analysis (n = 186) and 144 patients who underwent polysomnography due to some reasons but ruled out of having OSAS were included in the study. Read More

Aging Male 2019 Mar 29:1-7. Epub 2019 Mar 29.

d Department of Urology , School of Medicine, College of Medicine, Taipei Medical University , Taipei , Taiwan.

Introduction: We aimed to evaluate the predictive value of sex hormone levels on 3-month functional outcomes after acute ischemic stroke (AIS) in males.

Materials And Methods: A total of 110 male AIS patients were included in this prospective study. Serum levels of testosterone and estradiol were measured at admission. Read More

Aging Male 2019 Mar 29:1-5. Epub 2019 Mar 29.

a Faculty of Medicine, Department of Cardiovascular Surgery , Abant Izzet Baysal University , Bolu , Turkey.

Objective: To determine whether complete blood count parameters could be used as the biomarkers of inflammation in patients with in peripheral arterial disease.

Methods: Seventy-five patients with peripheral arterial disease (study group) and 75 healthy subjects (control group) were included in this retrospective study. Their baseline clinical characteristics and laboratory data were recorded and compared. Read More

Aging Male 2019 Mar 29:1-6. Epub 2019 Mar 29.

a Department of Electrocardiology , Upper Silesian Medical Centre , Katowice , Poland.

Aim: Symptoms of cardiac arrhythmias and the perception of the implantation of a cardiac pacemaker can negatively affect mental health including sexuality and sexual behaviors. The aim of this study was to assess the attitude towards sexuality and sexual behaviors among men with cardiac arrhythmias.

Methods: The study included 80 men (aged 58. Read More

Aging Male 2019 Mar 29:1-7. Epub 2019 Mar 29.

a Urology , University of Health Sciences Izmir Bozyaka Education and Research Hospital , Izmir , Turkey.

Aim: To investigate association of androgen deprivation therapy (ADT) with depression and the effect of depression on cognitive functions in men with locally advanced or metastatic prostate cancer.

Methods: A total of 144 patients were evaluated in a prospective, comparative study. Group1 consisted of 72 patients with locally advanced or metastatic prostate cancer who received complete ADT treatment continuously for 12 months and group2 (control group) consisted of 72 patients who underwent radical prostatectomy without any additional treatment. Read More

Aging Male 2019 Mar 23:1-5. Epub 2019 Mar 23.

d Department of Urology , Dr Suat Seren Chest Diseases and Surgery Training and Research Hospital , Izmir , Turkey.

Objective: To evaluate the effects of hyperbaric oxygen therapy (HBOT) on erectile functions and serum testosterone levels in patients with erectile dysfunction (ED).

Methods: The patients treated by HBOT for several diseases between July 2017-May 2018 and had erectile dysfunction were included in the study. All patients filled the International Index of Erectile Function (IIEF) questionnaire form; serum total testosterone (TT) and free testosterone (FT) levels were examined before the first day and after the last day of HBOT. Read More

Aging Male 2019 Mar 23:1-5. Epub 2019 Mar 23.

c Department of Urology & Andrology , Hamad General Hospital , Doha , Qatar.

Overactive bladder (OAB) is characterized by the storage symptoms of urgency with or without urgency incontinence. Although there is no clear cause of this idiopathic disease, overall prevalence of OAB symptoms in individuals aged 40 years old is more than 15%. Oxytocin, which is one of the most powerful contracting neuropeptide, was also shown to exhibit high intrinsic contractile activity on detrusor muscle. Read More

Aging Male 2019 Mar 23:1-8. Epub 2019 Mar 23.

a Department of General Medicine , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.

Purpose: The aim of the present study was to determine how age-related decreases in serum dehydroepiandrosterone sulfate (DHEAS) levels affect various physiological processes.

Methods: We retrospectively reviewed the medical records of patients in whom serum DHEAS levels were measured in our department and assessed the relationships between serum DHEAS levels and various patient characteristics.

Results: Among the 149 patients included in our analysis (mean age: 52. Read More

Aging Male 2019 Mar 16:1-6. Epub 2019 Mar 16.

a Department of Urology, Policlinico San Martino Hospital , University of Genova , Genova , Italy.

Objectives: The etiopathogenesis of Peyronie's disease (PD) remains not clearly understood. The most accepted theory attributes the histological lesions of PD to the effects of trauma to the corpora cavernosum of the penis. The aim of our study is to verify whether similar histological features exist between these two tissues, providing new evidence in favor of the traumatic theory in the etiopathogenesis of Peyronie's disease. Read More

Aging Male 2019 Mar 16:1-8. Epub 2019 Mar 16.

a 1 Department of Health Services Research , Maastricht University , Maastricht , Netherlands.

Background: Sub-Saharan Africa (SSA) countries are facing an epidemiological shift from infectious disease to chronic diseases, such as cardiovascular diseases (CVDs). CVDs incidence in SSA are frequently attributed to the prevalence of hypertension, diabetes, and overweight/obesity. Nevertheless, some researchers contend that CVDs are not a priority public health problem in SSA. Read More

Aging Male 2019 Mar 16. Epub 2019 Mar 16.

b Department of Urology , Cerrahpasa Medicine Faculty, Istanbul University , Istanbul , Turkey.

Aging Male 2019 Mar 16:1-4. Epub 2019 Mar 16.

a Department of Laboratory Medicine and Pathology , Hamad General Hospital , Doha , Qatar.

Mucor is an angioinvasive fungus that was reported mainly in immunocompromised patients. It usually presents as rhino-orbital, pulmonary, gastrointestinal, and disseminated disease. Isolated renal mucormycosis is an extremely rare infection in immunocompetent patients and is associated with high fatality rate. Read More

Aging Male 2019 Mar 12:1-7. Epub 2019 Mar 12.

a Department of Urology , Erzincan University Medical Faculty , Erzincan , Turkey.

Objective: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are the most common benign and malignant diseases of the prostate gland. The clinical distinction between BPH and PCa should be determined to guide patients to appropriate treatment. We aimed to evaluate the value of PSA, prostate volume (PV) and associated parameters for the detection of PCa in patients with PSA levels of 2. Read More

Aging Male 2019 Mar 12:1-7. Epub 2019 Mar 12.

a Department of Epidemiology and Biostatistics School of Public Health , Texas A&M University , College Station , TX , USA.

Objectives: To investigate whether testosterone replacement therapy (TRT) reduces prostate cancer (PCa) risk via stabilizing serum testosterone (T) levels beyond simply elevating serum T levels and whether TRT reduces PCa risk due to low serum T levels at a young age.

Methods: We analyzed data of 776 hypogonadal men from a urology center in Bremerhaven, Germany through 2004-2016 to investigate whether the TRT group has more stable T levels and whether TRT can reduce the risk of PCa due to low serum T levels at an early age. We derived an index, Maximum Decline of T Relative to Baseline (MDRB), to describe the magnitude of T declines and variations over time. Read More

Aging Male 2019 Mar 12:1-6. Epub 2019 Mar 12.

b Urology , Turkiye Cumhuriyeti Saglik Bakanligi Okmeydani Egitim ve Arastirma Hastanesi , Istanbul , Turkey.

Objective: To assess the safety and effectiveness of percutaneous nephrolithotomy in aging male patients.

Methods: Two hundred eighty-three male patients over the years of forty undergoing percutaneous nephrolithotomy between December 2009 and September 2014 were evaluated, retrospectively. The patients were stratified by four age groups [40-49 (group-1), 50-59 (group-2), 60-69 (group-3), ≥70 years (group-4)]. Read More

Aging Male 2019 Mar 11:1-9. Epub 2019 Mar 11.

f Department of Urology , Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine , Seoul , Korea.

Background: Real treatment rate among patients diagnosed with benign prostatic hyperplasia (BPH/LUTS) and also its association with sociodemographic factor (SDF) have not been extensively investigated.

Methods: Data were obtained from the 2006, 2008, 2010, 2012, 2014, and 2016 waves of the Korean Longitudinal Study of Aging (KLoSA). Among 10,254 individuals at the first baseline survey in 2006, a total of 4383 participants were ultimately included for final analysis. Read More

Aging Male 2019 Mar 8:1-6. Epub 2019 Mar 8.

a Department of Urology , Kanuni Sultan Suleyman Training and Research Hospital , Istanbul , Turkey.

Purpose: Investigate the factors affecting the efficacy of the widely used 12-quadrant prostate biopsy for the diagnosis of prostate cancer.

Methods: The data of 1846 male patients between 45 and 75 years of age was evaluated. The patients were subdivided into groups according to age, blood prostate-specific antigen (PSA) levels prostate volume (PV), digital rectal examination (DRE) findings, and pathology results. Read More

Aging Male 2019 Mar 7:1-6. Epub 2019 Mar 7.

d Center for science, Clinical cente of Montenegro , Podgorica , Montenegro.

We aimed to analyze the correlation of perineural invasion on transrectal ultrasound guided prostate biopsy with predictors of biochemical cancer recurrence, as well as its impact on clinical outcomes, for non-metastatic prostate cancer. For the study, patients with perineural invasion (N = 86) were recruited into group I and underwent open retropubic prostatectomy, regardless of clinical stage; cases with prostate cancer but without perineural invasion on biopsy, who received radical prostatectomy as the treatment modality, were placed into group II (n = 90). Perineural invasion was detected preoperatively in 43% of cases that revealed surgical margin positivity postoperatively, while 85% of the remaining cases (group II) had negative surgical margins. Read More

Aging Male 2019 Mar 5:1-2. Epub 2019 Mar 5.

b Brooks Rehabilitation College of Healthcare Sciences, Jacksonville University , Jacksonville , FL, USA.

Our findings indicate that the participants of an 18 week intensive endurance exercise training program experienced significant (p < 0.001) reductions in resting testosterone (-25 to -45% decrease from pre-training), with some reaching the clinical criteria for androgen deficiency during the training regimen. Nonetheless, none of the participants displayed any running performance decrement, in fact, the opposite occurred (+18. Read More

Aging Male 2019 Mar 1:1-8. Epub 2019 Mar 1.

c Faculty of Health Sciences , University of Avrasya , Trabzon , Turkey.

Aim: In this study our aim was to evaluate the nosocomial infections and to understand factors affecting the cost of used antibiotics in palliative care unit.

Materials And Methods: Between 2016 and 2017, 113 patients were included in the study in palliative care unit of University of Health Sciences Bursa Yuksek Ihtisas Research and Training Hospital. Patients medical records were analyzed retrospectively for nosocomial infections, chronic diseases, presence of decubitis ulcers, opioid use, enteral, parenteral feedings, mortality and antibiotic cost. Read More

Aging Male 2019 Feb 20:1-12. Epub 2019 Feb 20.

d Private Urology Practice , Bremerhaven , Germany.

Objective: The association between erectile dysfunction (ED), hypogonadism, cardiovascular disease, and type 2 diabetes is well documented, but long-term data are limited. The aim of this study is to investigate effects of long-term testosterone therapy (TTh) with testosterone undecanoate in men with hypogonadism and ED.

Patients And Methods: Observational, prospective registry of 805 hypogonadal men with different degrees of ED, evaluated by the International Index of Erectile Function - Erectile Function Domain. Read More

Aging Male 2019 Feb 19:1-7. Epub 2019 Feb 19.

a Department of Urology , Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai , China.

Objective: Our study aimed to investigate the age-related growth in prostatic morphological parameters in Chinese benign prostatic hyperplasia (BPH) patients, and to find out the regularity of how these parameters change with aging.

Methods: Medical records of 1038 BPH patients were obtained from a retrospective database of first-visit men with BPH. Change regularity of prostatic anatomical factors with aging was analyzed. Read More

Aging Male 2019 Feb 19:1-6. Epub 2019 Feb 19.

b Department of Urology , Catalca Ilyas Cokay State Hospital , Istanbul , Turkey.

Objective: Research evaluating the relationship between the Monocyte/HDL-C ratio (MHR) and ED is limited in number. We aimed for determining whether MHR could be an early marker of ED in our study.

Material And Methods: Eighty-nine patients diagnosed with ED during the period of April 2018-November 2018 and 100 patients that did not have any systemic diseases and erectile dysfunction were included in our study. Read More

Aging Male 2019 Feb 15:1-7. Epub 2019 Feb 15.

b Department of Nursing, Faculty of Nursing and Midwifery , Ilam University of Medical Sciences , Ilam , Iran.

Introduction: Whilst self-care programme involving comprehensive lifestyle plans including physical and behavioural interventions have reported positive outcomes for the aged suffering from urinary incontinence (UI), very few programmes have been implemented amongst Iranian nursing home residents, particularly in men.

Objectives: The aim of this study was to examine the effect of a self-care programme on UI and self-esteem in elderly men dwelling in nursing homes in Iran.

Materials And Methods: Sixty-one elderly men (aged 60-75 years of age), at two different sites and living in nursing homes in the west of Iran, suffering from urinary incontinence were included in this study. Read More

Aging Male 2019 Feb 15:1-4. Epub 2019 Feb 15.

b Department of Infectious Diseases and Clinical Microbiology , Siirt State Hospital , Siirt , Turkey.

Objective: Brucellosis is a multisystemic disease which may affect all organs. Epididymo-orchitis is the most common form of genitourinary involvement. The aim of this study was to present our eight-year experience regarding the management of patients with brucellar epididymo-orchitis (BEO). Read More

Aging Male 2019 Feb 15:1-10. Epub 2019 Feb 15.

b Laboratory of Physiology and Biochemistry of Exercise Faculty of Human Kinetics , Universidade de Lisboa , Cruz Quebrada , Portugal.

Hypogonadism affects an extensive part of the male population, especially among the elderly. The quest for treatment regarding low levels of serum testosterone and male infertility has, therefore, worldwide relevance. Zinc has important biological actions insofar as the male reproductive physiology and endocrine system. Read More

Aging Male 2019 Feb 11:1-13. Epub 2019 Feb 11.

a Hacettepe Universitesi , Ankara , Turkey.

In this article, the gerontological factors affecting the successful aging of the elderly have been uncovered, the quality of life and successful aging issues have been related to gerontology and investigated on a different dimension. It has been emphasized that the importance of gerontechnology on the successful aging, creation of awareness through formal and non-formal education, qualitative and quantitative researches should be increased. Qualitative and quantitative researches on the subject were evaluated together, gerontology and gerontechnology were considered together with successful aging, and gerontology functions and ergonomics should be taken into consideration in increasing quality of life. Read More

Aging Male 2019 Feb 10:1-8. Epub 2019 Feb 10.

a Center for Evidence-Based and Translational Medicine , Zhongnan Hospital of Wuhan University , Wuhan , China.

Objective: To investigate the correlation of clinical measurements on normal and abnormal fasting blood glucose (FBG) with benign prostatic hyperplasia (BPH).

Methods: From September 2016 to January 2018, 771 BPH patients were enrolled for further selection. The eligible patients were divided into normal FBG, impaired fasting glucose (IFG), and high risk of type 2 diabetes mellitus (HR-T2DM) groups. Read More

Aging Male 2019 Feb 10:1-7. Epub 2019 Feb 10.

e Department of Pulmonary Diseases , Sureyyapasa Chest Disease and Thoracic Surgery Training and Research Hospital , Istanbul , Turkey.

Objectives: We aimed to investigate the effect of kinesiotaping (KT) on the respiratory parameters as measured by spirometry and depression in the chronic obstructive pulmonary disease (COPD) patients.

Methods: In this prospective, randomized, controlled, single-blind study 42 male patients with COPD diagnosis were randomized into two groups. In Group1 (n = 21) routine COPD medical treatment plus kinesiotaping and in Group2 (n = 21) only routine COPD medical treatment was given. Read More

Aging Male 2019 Feb 10:1-6. Epub 2019 Feb 10.

a Department of Cardiology , Faculty of Medicine, Van Yuzuncu Yil University , Van , Turkey.

Aim: Coronary slow flow (CSF) is defined as late opacification in epicardial coronary arteries with no significant stenosis. The aim of this study is to evaluate the relationship between ischemia-modified albumin (IMA) by using Spectrophotometer in CSF.

Methods: Level of IMA was measured by spectrophotometer. Read More

Aging Male 2019 Jan 16:1-8. Epub 2019 Jan 16.

a Department of Urology , Hallym University Kangdong Sacred Heart Hospital , Seoul , Korea.

Purpose: Postmicturition dribbling (PMD) is a stressful symptom in middle-aged men characterized by urinary leakage after the completion of normal voiding. Appropriate treatments have not yet been introduced. This study assessed the efficacy of treatment of PMD with 75 mg udenafil daily. Read More

Aging Male 2019 Jan 16:1-7. Epub 2019 Jan 16.

a Department of Urology , Nagoya University Graduate School of Medicine , Nagoya , Japan.

Introduction: To investigate possible pre-treatment factors related to the therapeutic effect of tadalafil on bladder outlet obstruction (BOO).

Materials And Methods: Eighty untreated outpatients with lower urinary tract symptoms (LUTS) due to BOO received 5 mg tadalafil daily for 12 months. Subjective symptoms and objective findings were evaluated before and 12 months after treatment. Read More

Aging Male 2019 Jan 16:1-3. Epub 2019 Jan 16.

a Department of Urology , Hereford County Hospital , Hereford , UK.

Seminal Vesicle (SV) calculi are a rare pathology. Clinical presentation usually consists of nonspecific perineal pain and haematospermia. Adjuncts to aid diagnosis include US, MRI, and Vesiculography. Read More

Aging Male 2019 Jan 16:1-12. Epub 2019 Jan 16.

c Department of Urology , Affiliated Hospital of the Qingdao University , Qingdao , China.

Objective: We performed this meta-analysis to assess serum testosterone changes in adult males with Type 2 diabetes (T2DM).

Methods: PubMed, Embase, Web of Science, and Cochrane Library were searched to identify qualified studies. Pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs) were utilized to test the changes of total testosterone (TT), free testosterone (FT) and sex hormone-binding globulin (SHBG) in patients with T2DM. Read More

Aging Male 2019 Jan 16:1-6. Epub 2019 Jan 16.

a Department of Urology , MacKay Memorial Hospital , Taipei, Taiwan.

Aim: In this study, we administered a questionnaire to consecutive prostate cancer patients who received androgen deprivation therapy (ADT) for understanding the prevalence of depression symptoms.

Materials And Methods: We retrospectively identified patients with prostate adenocarcinoma who received ADT between January 2015 and February 2018 at Mackay Memorial Hospital. The patients were then asked to complete the Chinese version of the Patient Health Questionnaire-9 (PHQ-9) during an interview. Read More

Aging Male 2019 Jan 16:1-6. Epub 2019 Jan 16.

a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.

Objective: This study investigated the efficacy of 5-year testosterone replacement therapy (TRT) on lipid profile and glucose tolerance in Japanese hypogonadal men.

Methods: Fourteen patients, who received continuous TRT for 5 years, and 22 controls with 5-year observations were enrolled. The patients in the TRT group had received intramuscular injections of testosterone enanthate (250 mg) every month for 5 years. Read More

Aging Male 2019 Jan 16:1-10. Epub 2019 Jan 16.

e Department of Biochemistry , Yildirim Beyazit University Faculty of Medicine , Ankara , Turkey.

Serum Total Thiol (TT), Native Thiol (NT), and Disulfide (SS) levels were found significantly lower in benign proliferative pathologies and cancer disease compared to healthy subjects. We conducted this prospective study to investigate the possible predictive and prognostic significance of these markers in non-small cell lung cancer (NSCLC), which is one of the most associated cancers with oxidative stress. This was a non-randomized, prospective, and case-control study of 120 subjects, including 60 patients with metastatic or inoperable NSCLC at the time of diagnosis and 60 demographically-matched controls. Read More

Aging Male 2019 Jan 16:1-10. Epub 2019 Jan 16.

a The Department of Reproductive Health , Centre of Postgraduate Medical Education , Warsaw , Poland.

Inhibitors of 5α-steroid reductase are drugs used to treat androgen-dependent conditions including prostate diseases and androgenic alopecia. Finasteride was the first on the market and is currently the most widely used inhibitor. Dutasteride was the second inhibitor to be approved and has a similar safety profile. Read More

Aging Male 2019 Jan 16:1-7. Epub 2019 Jan 16.

b Good Hope Hospital , Birmingham , UK.

In this commentary, we highlight important findings from a notable RCT by Ng Tang Fui et al. 2016 which investigated the effects of testosterone treatment in dieting obese men. First, a myopic focus on weight loss can detract from important improvements in body composition. Read More

Aging Male 2019 Jan 16:1-12. Epub 2019 Jan 16.

a School of Nursing , The Hong Kong Polytechnic University , HungHom , Hong Kong.

Objectives: The negative impact of lower urinary tract symptoms (LUTS) on affected males is substantial. This study aims to assess whether a combined auriculotherapy (AT) using laser AT (LAT) and magneto-AT (MAT) is more effective than using MAT alone or placebo for managing LUTS of aging males.

Methods: A randomized controlled, double-blinded trial was conducted. Read More

Aging Male 2019 Jan 16:1-7. Epub 2019 Jan 16.

e Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences , Tehran , Iran.

Objectives: The current study was conducted to examine the severity of hypogonadism symptoms and their risk factors among the male employees of Tehran University of Medical Sciences (TUMS).

Methods: This cross-sectional study was conducted on 80 male employees aged 40-60 years, with hypogonadism, at TUMS. The participants were selected through census sampling. Read More