33 results match your criteria Aging Health[Journal]

  • Page 1 of 1

infection in older adults.

Authors:
Robin Lp Jump

Aging health 2013 Aug;9(4):403-414

Geriatric Research Education & Clinical Center & Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA ; Division of Infectious Diseases & HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

infection, the most frequent cause of nosocomial diarrhea, disproportionately affects older adults. The two most important risk factors for developing infection are antimicrobial exposure and age >65 years old. Risk factors specific to older adults are frequent interactions with healthcare systems and age-related changes in physiology, including immune senescence and changes to the gut microbiome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.13.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061705PMC
August 2013
11 Reads

Urinary tract infection in older adults.

Aging health 2013 Oct;9(5)

Yale Univeristy School of Medicine, Department of Internal Medicine, Section of Infectious Diseases, PO Box 208022, New Haven, CT 06520-8022, USA.

Urinary tract infection and asymptomatic bacteriuria are common in older adults. Unlike in younger adults, distinguishing symptomatic urinary tract infection from asymptomatic bacteriuria is problematic, as older adults, particularly those living in long-term care facilities, are less likely to present with localized genitourinary symptoms. Consensus guidelines have been published to assist clinicians with diagnosis and treatment of urinary tract infection; however, a single evidence-based approach to diagnosis of urinary tract infection does not exist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.13.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878051PMC
October 2013
7 Reads

Comparison of cardiac amyloidosis due to wild-type and V122I transthyretin in older adults referred to an academic medical center.

Aging health 2013 Apr;9(2):229-235

Clinical Cardiovascular Research Laboratory for the Elderly, Center for Advanced Cardiac Care, Division of Cardiology, Columbia College of Physicians & Surgeons, 622 West 168th Street, PH 12-1291, NY, USA.

Aims: In the USA, transthyretin cardiac amyloidosis usually results from 'wild-type' transthyretin (senile cardiac amyloidosis [SCA]) or the V122I variant.

Patients & Methods: We compared presentations and outcomes among SCA and V122I patients referred to the Center for Advanced Cardiac Care at Columbia University Medical Center (NY, USA) between 2001 and 2012.

Results: V122I patients were younger (mean: 71 years, standard deviation [SD]: 7) than SCA patients (mean: 77, SD: 6; p = 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.13.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780445PMC
April 2013
8 Reads

Late-Life Depression in Home Healthcare.

Aging health 2012 Jun;8(3):273-284

Weill Cornell Medical College.

Major depression is disproportionately common among elderly adults receiving home healthcare and is characterized by greater medical illness, functional impairment, and pain. Depression is persistent in this population and is associated with numerous poor outcomes such as increased risk of hospitalization, injury-producing falls, and higher health care costs. Despite the need for mental health care in these patients, significant barriers unique to the home healthcare setting contribute to under-detection and under-treatment of depression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.12.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587974PMC
June 2012
6 Reads

A pilot study of the effects of meditation on regional brain metabolism in distressed dementia caregivers.

Aging health 2012 Oct;8(5):509-516

Department of Molecular & Medical Pharmacology, University of California, Los Angeles, CA, USA.

AIMS: Caregiver distress can affect mood and cognition. Meditation can be used to reduce stress. This pilot study explored whether yogic meditation could change regional cerebral metabolism in distressed caregivers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.12.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558935PMC
October 2012
19 Reads
5 Citations

Common infections in nursing homes: a review of current issues and challenges.

Aging health 2011 Dec;7(6):889-899

University of Michigan, Division of Geriatrics, MI, USA.

Over 1.5 million people live in 16,000 nursing homes in the USA and experience an average of 2 million infections a year. Infections have been associated with high rates of morbidity and mortality, rehospitalization, extended hospital stay and substantial healthcare expenses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/AHE.11.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526889PMC
December 2011
6 Reads

Social determinants and osteoarthritis outcomes.

Aging health 2012 Aug;8(4):413-437

Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 3300 Thurston Building, Chapel Hill, NC 27599, USA ; Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Osteoarthritis (OA) is one of the most frequently occurring musculoskeletal diseases, posing a significant public health problem due to its impact on pain and disability. Traditional risk factors fail to account for all of the risk observed for OA outcomes. In recent years, our view of disease causation has broadened to include health risks that are created by an individual's socioeconomic circumstances. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.12.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519433PMC
August 2012
61 Reads

Adjuvant chemotherapy and targeted therapy in elderly non-small-cell lung cancer patients.

Authors:
Aminah Jatoi

Aging health 2012 Jun;8(3):309-316

Department of Oncology, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA, Tel.: +1 507 284 3902.

Adjuvant chemotherapy and targeted therapies comprise two salient practice-changing improvements in the treatment of non-small-cell lung cancer. Despite the fact that these improvements have been largely data-driven, the following questions arise: what is the role of adjuvant chemotherapy in elderly patients with non-small-cell lung cancer? What is the role of targeted agents, such as erlotinib and bevacizumab, in older non-small-cell lung cancer patients? These questions are relevant because the current median age of lung cancer patients at diagnosis in the USA is 69 years, and the number of older patients developing this malignancy is increasing. This review provides guidance on how best to approach the use of adjuvant chemotherapy and targeted therapies in older patients with this disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.12.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505034PMC
June 2012
7 Reads

Anxiety and verbal memory performance in APOE-4 carriers and noncarriers aged 50 years and above.

Aging health 2012 Feb;8(1):99-104

University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Los Angeles, CA 90095, USA.

AIMS: The current study sought to explore the relationship between state and trait anxiety and delayed verbal memory performance in APOE-4 carriers and noncarriers who were aged 50 years and above. MATERIALS #ENTITYSTARTX00026; METHODS: The study was a retrospective analysis of 267 participants aged 50 years and above who had completed genetic testing for APOE status, the State-Trait Anxiety Inventory, and a comprehensive neuropsychological battery that included three delayed verbal memory measures (Wechsler Memory Scale - 3rd Edition, Logical Memory and Verbal Pairs subtests and the Buschke Selective Reminding Test). RESULTS: An inverse relationship was found between state anxiety and delayed verbal memory performance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.11.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420064PMC
February 2012
10 Reads

Difficulties sleeping: a natural part of growing older?

Aging health 2012 Jun;8(3)

Respiratory Specialists, Wyomissing, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.12.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825262PMC
June 2012
10 Reads

How does hearing loss affect the brain?

Aging health 2012 Apr;8(2):107-109

Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/AHE.12.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811604PMC
April 2012
8 Reads

Common dietary supplements for cognitive health.

Authors:
Mk Gestuvo Ww Hung

Aging health 2012 Feb;8(1):89-97

Department of Geriatrics and Palliative Medicine, Mount Sinai School of Medicine, New York, NY, USA.

Advancing age is a major risk factor for cognitive impairment and dementia. Currently, there are no effective preventive strategies for cognitive decline. Since physicians have no drug therapies to offer, patients and families may turn to complementary and alternative medicine to preserve cognition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/AHE.11.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311304PMC
February 2012
12 Reads

Early intranasal insulin therapy halts progression of neurodegeneration: progress in Alzheimer's disease therapeutics.

Aging health 2012;8(1):61-64

Departments of Pathology (Neuropathology), Neurology, Neurosurgery, and Medicine, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI.

Craft S, Baker LD, Montine TJ, Minoshima S, Watson GS, Claxton A, et al. Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment: A Pilot Clinical Trial. . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.11.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743662PMC
January 2012
13 Reads

Language performance in postmenopausal women with and without hormone therapy and men.

Aging health 2012;8(6):625-632

Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, CA 90024, USA ; Longevity Center Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA 90024, USA.

Aims: In the current study, we explored the potential effects of hormone therapy (HT) on language functioning in healthy, postmenopausal women and compared them with men of similar ages.

Materials & Methods: Language functioning on tasks of verbal fluency and object naming was examined in 100 participants (mean age: 61.9 years; 33 HT users, 15 HT non-users and 52 men) at baseline and follow-up (mean follow-up time period: 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.12.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332702PMC
January 2012
17 Reads

The aging immune system and its relationship with cancer.

Aging health 2011 Oct;7(5):707-718

National Cancer Institute (NCI), Experimental Transplantation & Immunology Branch (ETIB), 10 Center Dr. 10 CRC, 3-3330 Bethesda, MD 20814, USA.

The incidence of most common cancers increases with age. This occurs in association with, and is possibly caused by a decline in immune function, termed immune senescence. Although the size of the T-cell compartment is quantitatively maintained into older age, several deleterious changes (including significant changes to T-cell subsets) occur over time that significantly impair immunity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.11.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222953PMC
October 2011
10 Reads

Changing nature of cardiac interventions in older adults.

Aging health 2011 Apr;7(2):283-295

Division of Cardiology, Columbia University Medical Center, NY, USA.

Older adults represent a rapidly growing segment of the population in developed countries. Advancing age is the most powerful risk factor for the development of cardiovascular disease (CVD), and CVD-related mortality increases markedly in older individuals. Procedures for patients with CVD, including percutaneous coronary intervention, aortic valve replacement and implantable cardioverter defibrillators were all initially validated in younger individuals but are increasingly being applied in older adults who for the most part have been significantly understudied in clinical trials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.11.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129702PMC
April 2011
21 Reads

Exercise in aging: its important role in mortality, obesity and insulin resistance.

Authors:
Alice S Ryan

Aging health 2010 Oct;6(5):551-563

VA Research Service, Department of Medicine, University of Maryland School of Medicine & the Baltimore Geriatric Research, Education & Clinical Center (GRECC), VA Maryland Health Care System, Baltimore, MD 21201, USA,

The prevalence of overweight and obesity has increased dramatically over the last several decades. Obesity and physical inactivity increase the risk for cardiovascular disease, Type 2 diabetes mellitus, hypertension, dyslipidemia and certain cancers. Obesity and low levels of physical fitness are also associated with increased risk of all-cause and cardiovascular mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.10.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042702PMC
October 2010
6 Reads

Optimizing bone health in older adults: the importance of dietary protein.

Aging health 2010 Jun;6(3):345-357

Department of Allied Health Science, 358 Mansfield Rd, Box U-2101, University of Connecticut, Storrs, CT 06269-2101, USA.

Age-related bone loss is progressive and can lead to osteoporosis. While it is accepted that both dietary calcium and vitamin D are important and beneficial for skeletal health, the impact of dietary protein on calcium metabolism and bone balance remains controversial. Contrary to the hypothesis that increasing dietary protein contributes to bone loss, research supports the notion that protein may play a pivotal role in maintenance of bone health by several mechanisms; for example, increasing dietary protein increases IGF-1, calcium absorption, muscle strength and mass, all of which could potentially benefit the skeleton. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.10.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907525PMC
June 2010
9 Reads

Herpes zoster vaccine for the elderly: boosting immunity.

Aging health 2010 Apr;6(2):169-176

Division of Infectious Disease, University of Maryland School of Medicine, MD, USA, Tel.: +1 410 328 5039.

Herpes zoster, also known as shingles, is a disease that results from the reactivation of a latent infection of the varicella zoster virus, which is usually encountered during early childhood. Aging is associated with an increased risk for herpes zoster and its complications. Boosting immunological memory is the key strategy for keeping the latent varicella zoster virus infection under control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.10.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895943PMC
April 2010
8 Reads

Obesity in the elderly: is faulty metabolism to blame?

Aging health 2010 Apr;6(2):159-167

Pennington Biomedical Research Center, Baton Rouge, LA, USA, Tel.: +1 225 763 2893.

The fastest growing segment of the US population, and that of other developed countries, is the oldest-old (aged >85 years). Many children born after the year 2000 in countries with the longest lived residents may live to see their 100th birthday. The combination of reduced mortality along with reduced fertility in developed countries is producing 'population aging', and the comorbidities associated with aging are becoming important public health issues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.10.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885712PMC
April 2010
13 Reads
7 Citations

Promotion of cognitive health through cognitive activity in the aging population.

Authors:
Tiffany F Hughes

Aging health 2010 Feb;6(1):111-121

Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA, Tel.: +1 412 647 6619, ,

There is both popular and scientific interest in keeping the brain young and avoiding cognitive impairment and dementia. Older adults may be able to modify their cognitive health status through certain health behaviors. The aim of this review is to highlight the potential impact that cognitive activity may have on cognitive health outcomes in late life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.09.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850280PMC
February 2010
6 Reads

How does dementia affect driving in older patients?

Aging health 2010 Feb;6(1):77-85

Department of Neurology, Warren Alpert Medical School of Brown University, RI, USA and The Alzheimer's Disease & Memory, Disorders Center, Rhode Island Hospital, RI, USA, Tel.: +1 401 444 6440, ,

Driving is a complex activity that always becomes impaired at some point in older adults with degenerative dementia. Over time, disruption of the visual processing circuits of the brain that link the occipital and prefrontal regions, particularly in the right hemisphere, leads to increasing degrees of driving impairment that ultimately preclude safe driving. Neuropsychological tests of visuospatial ability, executive function and attention that tap into the integrity of these brain regions provide the clinician with important information regarding the need for a formal determination of driving competence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.09.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847266PMC
February 2010
7 Reads

Nutrition and late-life depression: etiological considerations.

Authors:
Martha E Payne

Aging health 2010 Feb;6(1):133-143

Department of Psychiatry & Behavioral Sciences, Neuropsychiatric Imaging Research Laboratory, Duke University, 2200 West Main Street, Suite B210, Durham, NC 27705, USA, Tel: + 1 919 416 7543, ,

Depression is a debilitating mental disorder that frequently occurs in older adults, especially in those with vascular diseases. Nutritional factors have the potential to decrease the occurrence of late-life depression but have not been adequately studied. Low folate levels, disturbed omega-3 fatty acid metabolism and obesity have been associated with depression, and may be causal factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.09.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841351PMC
February 2010
6 Reads

Effects of aging on the adaptive immune response to respiratory virus infections.

Aging health 2009 Dec;5(6):775

Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA, Tel.: +1 319 335 8433.

Severe acute respiratory disease caused by respiratory virus infections in individuals aged 65 years and older and in high-risk adults, such as those with chronic cardiopulmonary disorders, is associated with increased hospitalization and mortality rates. Epidemiological studies have identified influenza virus and respiratory syncytial virus as the most frequent causes of virus-induced respiratory disease in elderly and high-risk adults. Studies in both humans and animal models have established fundamental defects in cell-mediated and humoral immune responses in aged individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.09.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822389PMC
December 2009
6 Reads

BONE MARROW, THYMUS AND BLOOD: CHANGES ACROSS THE LIFESPAN.

Authors:

Aging health 2009 Jun;5(3):385-393

The aim of this review is to present age-related changes in the bone marrow and thymus and their effects in later life. Age-related hematologic changes are marked by a decline in marrow cellularity, increased risk of myeloproliferative disorders and anemia, and a decline in adaptive immunity. The exact mechanisms that produce these changes remain undefined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.09.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805199PMC
June 2009
6 Reads

Influenza vaccination in the elderly: seeking new correlates of protection and improved vaccines.

Aging health 2008 Dec;4(6):603-613

Department of Medicine, University of British Columbia, Vancouver, Canada and, Center for Immunotherapy of Cancer & Infectious Diseases, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-1601, USA, Tel.: +1 604 806 9153, ,

Influenza is foremost among all infectious diseases for an age-related increase in risk for serious complications and death. Determining the benefit of current influenza vaccines is largely limited to epidemiologic studies, since placebo-controlled trials of influenza vaccines are no longer considered ethical in the older adult population. Vaccine effectiveness is calculated from the relative reduction in influenza outcomes in individuals who elect to be vaccinated compared with those who do not, the assumptions for which are diverse and have led to considerable controversy as to the exact benefit of influenza vaccination in older adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/1745509X.4.6.603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790215PMC
December 2008
6 Reads

Complementary and alternative medicine use for treatment and prevention of late-life mood and cognitive disorders.

Authors:
Helen Lavretsky

Aging health 2009 Feb;5(1):61-78

Associate Professor of Psychiatry, Department of Psychiatry & Biobehavioral Sciences, and, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, Tel.: +1 310 794 4619, ,

Late-life mood disorders and cognitive aging are the most common reasons for using complementary and alternative therapies. The amount of rigorous scientific data to support the efficacy of complementary therapies in the treatment of depression or cognitive impairment is extremely limited. The areas with the most evidence for beneficial effects are exercise, herbal therapy (Hypericum perforatum), the use of fish oil, and, to a lesser extent, acupuncture and relaxation therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/1745509X.5.1.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772166PMC
February 2009
7 Reads

Epidemiology of HIV and response to antiretroviral therapy in the middle aged and elderly.

Authors:
Kelly A Gebo

Aging health 2008 Dec;4(6):615-627

Johns Hopkins University School of Medicine, 1830 E Monument St, Room 435, Baltimore, MD 21287, USA.

HIV is increasing in prevalence in the middle aged and older population owing to both increased longevity, and new infections in these populations. Highly active antiretrorival therapy (HAART) therapy may be less effective at restoring immune function in older patients compared with younger patients. There are significant toxicities associated with HAART therapy that, combined with decreased renal and liver function in older patients, may be more problematic in older HIV-infected patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/1745509X.4.6.615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776752PMC
December 2008
6 Reads

Changes in immune function in asthma in the elderly.

Aging health 2009 Sep;5(4):551-559

Asthma is an inflammatory disorder of the airway. The airway inflammation of asthma is typically an allergic inflammation characterized by cells and mediators described as a "Th2" inflammatory response. There is a growing body of evidence describing changes in the function of immune cells upon aging, a phenomenon referred to as "immunosenescence". Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.09.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359620PMC
September 2009
9 Reads

Community-acquired pneumonia in elderly patients.

Aging health 2009 ;5(6):763-774

The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Pulmonary & Critical Care Medicine, San Antonio, TX, USA, Tel.: +1 210 617 5256, ,

Community-acquired pneumonia continues to have a significant impact on elderly individuals, who are affected more frequently and with more severe consequences than younger populations. As the population ages it is expected that the medical and economic impact of this disease will increase. Despite these concerns, little progress has been made in research specifically focusing on community-acquired pneumonia in the elderly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ahe.09.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917114PMC
January 2009
7 Reads

Role of the renin-angiotensin system in age-related sarcopenia and diastolic dysfunction.

Aging health 2008 Feb;4(1):37-46

University of Florida, Department of Aging & Geriatric Research, 1329 SW 16th Street, Room 5274, PO Box 100143, Gainesville, FL 32610-0143, USA, Tel.: +1 352 273 5727;

The purpose of this review is to describe how recent pharmacological and genetic studies have contributed to our understanding of the role of the renin-angiotensin system (RAS) in age-related sarcopenia and diastolic dysfunction. Treatment strategies are limited in the context of both of these conditions, although interventions, which include blockade of the RAS (using angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers) are successful and lead to improvements in functional outcomes that are not necessarily mediated by hemodynamic effects of the drugs. Studies in animal models of sarcopenia and diastolic dysfunction point to ubiquitous effects of RAS blockade on multiple biological mechanisms, including inflammation, oxidative damage and metabolic dysregulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/1745509X.4.1.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863036PMC
February 2008
8 Reads

Alzheimer's disease and the Blood-Brain Barrier: Past, Present and Future.

Aging health 2008 Feb;4(1):47-55

NIA-Layton Aging & Alzheimer's Disease Center, Oregon Health & Science University, Portland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/1745509X.4.1.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778025PMC
February 2008
7 Reads
  • Page 1 of 1