395,165 results match your criteria Aging Health[Journal]


The malnutrition overlap syndromes of cachexia and sarcopenia: a malnutrition conundrum.

Am J Clin Nutr 2018 Dec;108(6):1157-1158

Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, and Theme Aging, Karolinska University Hospital, Stockholm, Sweden.

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December 2018

Health Burden, Instrumental and Emotional Support Adequacy, and Depressive Symptoms in Older Men With HIV.

Gerontologist 2018 Dec 12. Epub 2018 Dec 12.

Virginia Tech Center for Gerontology, Virginia Polytechnic Institute and State University, Blacksburg.

Background And Objectives: Older adults with HIV face greater health burden than HIV-uninfected counterparts. Little is known about resources that might mediate the influence of physiological health burden on psychological well-being. Informed by the stress process model, we assessed the influence of multifaceted health burden indicators on depressive symptoms and evaluated the mediating effects of social support adequacy. Read More

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December 2018

Older HIV+ and HIV- Adults Provide Similar Definitions of Successful Aging: A Mixed-Methods Examination.

Gerontologist 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, University of California, San Diego.

Background And Objective: As HIV-infected (HIV+) individuals age, there is a need to understand successful aging (SA) from the patient perspective. This study compared SA definitions between HIV+ and HIV-uninfected (HIV-) older adults and then examined correlates of SA categories.

Research Design And Methods: Ninety-three HIV+ and 46 HIV- older (aged 50+) adults provided brief definitions of SA, which was examined using content analysis. Read More

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December 2018
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Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial.

J Gerontol A Biol Sci Med Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Background: Low-grade chronic inflammation, characterized by elevations in plasma Interleukin-6 (IL-6), is an independent risk factor of impaired mobility in older persons. Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (ω-3) may reduce IL-6 and may potentially improve physical function. To assess the main effects of the angiotensin receptor blocker losartan and ω-3 as fish oil on IL-6 and 400 m walking speed, we conducted the ENRGISE Pilot multicenter randomized clinical trial. Read More

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December 2018
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Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More

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December 2018

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age.

Cell Rep 2018 Dec;25(11):2992-3005.e5

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. However, with age, the balance is disrupted, and LT-HSCs produce a myeloid-biased output, resulting in poor immune responses to infectious challenge and the development of myeloid leukemias. Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. Read More

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December 2018

Extraversion personality, perceived health and activity participation among community-dwelling aging adults in Hong Kong.

PLoS One 2018 12;13(12):e0209154. Epub 2018 Dec 12.

School of Humanities and Communication, Guangdong University of Finance and Economics, Guangzhou, China.

Activity participation is essential to the wellbeing of aging adults. Divergent levels of activity participation within aging populations have been explained from diverse perspectives, but the interaction effects of key determinants, such as personality and health, are often ignored. This study examines the effects of extravert personality on aging adults' activity levels by addressing its interaction with perceived physical health and mental health. Read More

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December 2018
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Exploring the influence from whole blood DNA extraction methods on Infinium 450K DNA methylation.

PLoS One 2018 12;13(12):e0208699. Epub 2018 Dec 12.

Department of Pediatric Oncology and Hematology, Oslo University Hospital, Oslo, Norway.

Genome-wide DNA methylation studies are becoming increasingly important in unraveling the epigenetic basis of cell biology, aging and human conditions. The aim of the present study was to explore whether different methods for extracting DNA from whole blood can affect DNA methylation outcome, potentially confounding DNA methylation studies. DNA was isolated from healthy blood donors (n = 10) using three different extraction methods (i. Read More

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December 2018

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.

PLoS One 2018 12;13(12):e0208757. Epub 2018 Dec 12.

Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.

Premature baboons exhibit peripheral insulin resistance and impaired insulin signaling. 5' AMP-activated protein kinase (AMPK) activation improves insulin sensitivity by enhancing glucose uptake (via increased glucose transporter type 4 [GLUT4] translocation and activation of the extracellular signal-regulated kinase [ERK]/ atypical protein kinase C [aPKC] pathway), and increasing fatty acid oxidation (via inhibition of acetyl-CoA carboxylase 1 [ACC]), while downregulating gluconeogenesis (via induction of small heterodimer partner [SHP] and subsequent downregulation of the gluconeogenic enzymes: phosphoenolpyruvate carboxykinase [PEPCK], glucose 6-phosphatase [G6PASE], fructose- 1,6-bisphosphatase 1 [FBP1], and forkhead box protein 1 [FOXO1]). The purpose of this study was to investigate whether pharmacologic activation of AMPK with AICAR (5-aminoimidazole-4-carboximide riboside) administration improves peripheral insulin sensitivity in preterm baboons. Read More

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December 2018

Age threshold for recommending higher protein intake to prevent age-related muscle weakness: A cross-sectional study in Japan.

PLoS One 2018 12;13(12):e0208169. Epub 2018 Dec 12.

Departments of Health and Social Behavior, School of Public Health, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Although insufficient dietary protein intake is a known risk factor for age-related muscle weakness, the optimal age at which higher protein intake is required to prevent muscle weakness is yet to be determined. Using a population-based panel survey of community-dwelling people aged 50-75 years, this cross-sectional study aimed to find the age threshold at which a higher protein intake is associated with higher muscle strength. We utilized a dataset from the Japanese Study of Aging and Retirement conducted between 2007 and 2011. Read More

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December 2018

Validation of a single factor representing the indicators of metabolic syndrome as a continuous measure of metabolic load and its association with health and cognitive function.

PLoS One 2018 12;13(12):e0208231. Epub 2018 Dec 12.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany.

The metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease associated with reduced physical fitness, higher disease burden, and impaired cognitive functions. Little is known about the operation of these risk factors in older adults when considered comprehensively without relying on the cut-off values of the single MetS components. The three main aims of the current study were to: (i) establish a latent metabolic load factor (MetL), using confirmatory factor analysis (CFA), and representing a continuous measure of MetL, defined by indicators that are commonly used to separate MetS groups from healthy individuals; (ii) examine the associations of this MetL factor with objective health, and cognitive function in men and women; (iii) compare the magnitude of these associations to those observed for the individual indicators used to define the MetL factor as well to the classical categorized MetS vs. Read More

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December 2018

Physicochemical and microbiological characterization of the sensory deviation responsible for the origin of the special sherry wines "palo cortado" type.

PLoS One 2018 12;13(12):e0208330. Epub 2018 Dec 12.

Department of Chemical Engineering and Food Technology, Faculty of Sciences, University of Cadiz, Cadiz, Spain.

The aim of this study was to characterize the biochemical changes and microbiological processes involved in the sensory deviation of "sobretablas" wines during biological aging, which leads to the origin of special or rare "palo cortado" wines. Industrial trials of biological aging of "sobretablas" wines with the potential for the development of lactic acid bacteria (LAB) were performed to study this phenomenon. The results showed that sensory deviation was due to the development of malolactic fermentation (MLF) together with an attenuated aerobic metabolism of "flor" yeast. Read More

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December 2018
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Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages.

PLoS One 2018 12;13(12):e0207358. Epub 2018 Dec 12.

Leibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany.

The adhesion molecule and co-receptor of receptor tyrosine kinases, CD44, is expressed in all cells of the immune system, but also in numerous non-immune cells. CD44 plays roles in the cellular response to different pathogens. The molecular actions of CD44 during these processes are by and large still unknown. Read More

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December 2018

Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study.

PLoS One 2018 12;13(12):e0207885. Epub 2018 Dec 12.

Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, United States of America.

Two thirds of all persons with late-onset Alzheimer's disease (AD) are women. Identification of sex-based molecular mechanisms underpinning the female-based prevalence of AD would advance development of therapeutic targets during the prodromal AD phase when prevention or delay in progression is most likely to be effective. This 3-year brain imaging study examines the impact of the menopausal transition on Alzheimer's disease (AD) biomarker changes [brain β-amyloid load via 11C-PiB PET, and neurodegeneration via 18F-FDG PET and structural MRI] and cognitive performance in midlife. Read More

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December 2018

High Prevalence of Spinal Magnetic Resonance Imaging Findings in Asymptomatic Young Adults (18-22 Yrs) Candidate to Air Force Flight.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Headquarters Joint Force Command (HQ JFC) of the North Atlantic Treaty Organization (NATO), Lago Patria, Giugliano in Campania (NA), Italy.

Study Design: Cross-sectional, retrospective, magnetic resonance (MR) imaging study, performed during cadets' selection procedures of the Italian Air Force Academy.

Objective: To assess the prevalence of spinal MR imaging findings in asymptomatic young adults (18-22 yrs) candidate to Air Force Flight.

Summary Of Background Data: Spinal MR imaging findings are frequently detected in asymptomatic subjects. Read More

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December 2018

mTOR, glycotoxins and the parallel universe.

Authors:
Alan S Green

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

The Medical Practice of Dr. Alan S. Green, Little Neck, NY 11363, USA.

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December 2018
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Circular RNA EIF6 (Hsa_circ_0060060) sponges miR-144-3p to promote the cisplatin-resistance of human thyroid carcinoma cells by autophagy regulation.

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

Department of General Surgery, First Hospital of Shanxi Medical University, Taiyua, Shanxi 030001, China.

Anaplastic thyroid carcinoma (ATC) responds for the majority of death of thyroid carcinoma and often causes chemotherapy resistance. We investigated the influence of circEIF6 (Hsa_circ_0060060) on the cisplatin-sensitivity in papillary thyroid carcinoma (PTC) and ATC cells, and explored its regulation to downstream molecules miR-144-3p and Transforming Growth Factor α (TGF-α). Differentially expressed circRNAs in PTC were analyzed using the GSE93522 data downloaded. Read More

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December 2018

Sevoflurane impairs learning and memory of the developing brain through post-transcriptional inhibition of CCNA2 via microRNA-19-3p.

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

Department of Anesthesiology, Qianfoshan Hospital of Shandong Province, Affiliated to Shandong University, Jinan 250014, China.

The molecular mechanisms underlying sevoflurane (SEVO)-induced impairment of learning and memory remain unclear. Specifically, a role of microRNAs (miRNAs) in the control of the neuron proliferation in the developing brain exposed to SEVO has not been reported previously. Here, we studied the effects of SEVO exposure on the neural cell proliferation, and on the learning and memory of neonatal rats. Read More

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December 2018

[Operative treatment of acute mesenteric ischaemia].

Magy Seb 2018 Dec;71(4):149-154

Általános, Ér- és Plasztikai Sebészeti Osztály, Markusovszky Egyetemi Oktatókórház 9700 Szombathely, Markusovszky Lajos u. 5.

Introduction: The incidence of acute mesenteric ischemia (AMI) appears to be increasing due to aging in the population with increasing prevalence of comorbidities. Despite the wide-scale availability of diagnostic technologies, the timely detection and correct treatment are not ensured. This is due to the fact that the required CT angiography is not immediately performed and that vascular surgical reconstruction can be performed within the short ischemic tolerance window of the bowels amounting 4-6 hours. Read More

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December 2018

Poor estimates of motor variability are associated with longer grooved pegboard times for middle-aged and older adults.

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Integrative Physiology, University of Colorado, United States.

Goal-directed movements that involve greater motor variability are performed with an increased risk that the intended goal will not be achieved. The ability to estimate motor variability during such actions varies across individuals and influences how people decide to move about their environment. The purpose of our study was to identify the decision-making strategies used by middle-aged and older-adults when performing two goal-directed motor tasks and to determine if these strategies were associated with the time to complete the grooved pegboard test. Read More

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December 2018

Slowed Sensory Reweighting and Postural Illusions in Older Adults: The Moving Platform Illusion.

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

Psychology, Queen's University Belfast, Belgium.

We investigated whether postural after-effects witnessed during transitions from a moving to stable support are accompanied by a delayed perception of platform stabilization in older adults, in two experiments. In Experiment 1, postural sway and muscle co-contraction were assessed in eleven healthy young, eleven healthy older and eleven fall-prone older adults during blind-folded stance on a fixed platform, followed by a sway-referenced platform then followed by a fixed platform again. The sway-referenced platform was more compliant for young adults to induce similar levels of postural sway in both age groups. Read More

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December 2018

Refluxed Esterification of Fullerenes Conjugated P25 TiO2 Promotes Free Radical Scavenging Capacity and Facilitates Anti-aging Potentials in Human Cells.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Titanium dioxide nanomaterials have good capability to prevent human cells from damage under UV irradiation. However, some studies indicated that the nanoscale of titanium dioxide could potentially cause harmful effects such as free radicals generation under UV irradiation and thereby accelerate the progress of cell aging. Fullerenes can scavenge large amounts of free radicals due to the fact that fullerenes contain enormous amount of π electrons with low lying lowest unoccupied molecular orbital (LUMO), but its adverse properties, such as the poor solubility in water, restricted the applicability. Read More

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December 2018

Obesity and healthy aging: social, functional and mental well-being among older Canadians.

Health Promot Chronic Dis Prev Can 2018 Dec;38(12):437-444

Public Health Agency of Canada, Ottawa, Ontario, Canada.

Introduction: Canadians are living longer than before, and a large proportion of them are living with obesity. The present study sought to describe how older participants in the Canadian Longitudinal Study on Aging (CLSA) who are living with obesity are aging, through an examination of measures of social, functional and mental well-being.

Methods: We used data from the first wave of the CLSA for people aged 55 to 85 years in this study. Read More

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December 2018
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Serial position effects differ between Alzheimer's and vascular features in mild cognitive impairment.

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, National Neuroscience Institute, Singapore 308433, Singapore.

Individuals with mild cognitive impairment (MCI) exhibit varying serial position effect (SPE) performances. The relationship between SPE performance in word list recall and clinical, genetic, and neuroimaging features of MCI requires elucidation. 119 MCI and 68 cognitively normal (CN) participants underwent cognitive assessment, apolipoprotein E (ApoE) genotyping, and volumetric MRI brain scans processed via voxel-based morphometry. Read More

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December 2018

Cardiac Vagus and Exercise.

Physiology (Bethesda) 2019 Jan;34(1):71-80

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London , United Kingdom.

Lower resting heart rate and high autonomic vagal activity are strongly associated with superior exercise capacity, maintenance of which is essential for general well-being and healthy aging. Recent evidence obtained in experimental studies using the latest advances in molecular neuroscience, combined with human exercise physiology, physiological modeling, and genomic data suggest that the strength of cardiac vagal activity causally determines our ability to exercise. Read More

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January 2019

An update on the clinical consequences of polypharmacy in older adults: a narrative review.

Expert Opin Drug Saf 2018 Dec 12:1-12. Epub 2018 Dec 12.

a Aging Research Center, Department of Neurobiology , Care Sciences and Society, Karolinska Institutet & Stockholm University , Stockholm , Sweden.

Introduction: Polypharmacy, the use of multiple medications by one individual, is increasingly common among older adults. Caring for the growing number of older people with complex drug regimens and multimorbidity presents an important challenge in the coming years. Areas covered: This article reviews the international trends in the prevalence of polypharmacy, summarizes the results from previous reviews on polypharmacy and negative health outcomes, and updates a previous review on the clinical consequences of polypharmacy by focusing on studies published after 2013. Read More

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December 2018

Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain.

J Cereb Blood Flow Metab 2018 Dec 12:271678X18818291. Epub 2018 Dec 12.

1 Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark.

The aging brain is associated with atrophy along with functional and metabolic changes. In this study, we examined age-related changes in resting brain functions and the vulnerability of brain physiology to hypoxic exposure in humans in vivo. Brain functions were examined in 81 healthy humans (aged 18-62 years) by acquisitions of gray and white matter volumes, cerebral blood flow, cerebral oxygen consumption, and concentrations of lactate, N-acetylaspartate, and glutamate+glutamine using magnetic resonance imaging and spectroscopy. Read More

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December 2018

Parkinson's disease: a short story of 200 years.

Histol Histopathol 2018 Dec 12:18073. Epub 2018 Dec 12.

Clinical and Experimental Neuroscience Group (NiCE-IMIB), Department of Human Anatomy and Psychobiology, Institute for Aging Research, School of Medicine, University of Murcia, Murcia, Spain.

After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and incidental neurodegenerative disorder, affecting more than 2% of the population older than 65 years old. Since it was first described 200 years ago by Dr James Parkinson, great steps have been made in the understanding of the pathology. However, the cause(s) that initiates and perpetuates the neurodegenerative process is (are) still not clear. Read More

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December 2018

Voluntary wheel running: patterns and physiological effects in mice.

Braz J Med Biol Res 2018 Dec 10;52(1):e7830. Epub 2018 Dec 10.

Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil.

Exercise can prevent and improve the pathophysiology of diseases and promote healthy aging. Thus, understanding the mechanisms that regulate the beneficial effects of exercise may lead to the development of new strategies to enhance quality of life and to counteract chronic diseases. Voluntary wheel running is an interesting model to study the effects of exercise in mice. Read More

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December 2018

Management Recommendations on Sleep Disturbance of Patients with Parkinson's Disease.

Chin Med J (Engl) 2018 Dec;131(24):2976-2985

National Parkinson Foundation Centre of Excellence and The Maurice Wohl Clinical Neuroscience Institute, King's College London and King's College Hospital, London WC2R 2LS, UK.

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December 2018
1.016 Impact Factor

Essential oils and functional herbs for healthy aging.

Neural Regen Res 2019 Mar;14(3):441-445

School of Pharmacy and Applied Science, La Trobe Institute for Molecular Sciences, La Trobe University, Bendigo, Australia.

As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in the brain and cholinergic deficits leads to cognitive dysfunction and decline. Read More

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March 2019
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An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis.

Cytokine 2019 Jan 28;113:1-12. Epub 2018 Jun 28.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address:

Osteoarthritis is the most prevalent form of aging-related joint diseases, and its etiology is still not fully understood. Obesity has been recognized as one of the most significant and potentially preventable risk factors for osteoarthritis. Beyond mechanical loading, adipokines, including leptin, visfatin, adiponectin, resistin and others, are demonstrated to have metabolic implications in the pathogenesis and progression in obesity-induced osteoarthritis by modulating the pro/anti-inflammatory and anabolic/catabolic balance, apoptosis, matrix remodeling and subchondral bone ossification. Read More

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January 2019

Aging, immune senescence, and immunotherapy: A comprehensive review.

Semin Oncol 2018 Aug 24;45(4):187-200. Epub 2018 Oct 24.

Department of Microbiology, Boston University School of Medicine, Boston, MA, USA; Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA.

The advent of immune checkpoint inhibitors (ICIs) has changed the landscape of cancer treatment. Older adults represent the majority of cancer patients; however, direct data evaluating ICIs in this patient population is lacking. Aging is associated with changes in the immune system known as "immunosenescence" that could impact the efficacy and safety profile of ICIs. Read More

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Comparison of four sarcopenia screening tools in nursing home residents.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Health Management Center, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu, Sichuan, China.

Background: Several screening tools have been developed for identifying sarcopenia in elderly nursing home residents.

Objective: To compare the diagnostic accuracy of four sarcopenia screening tools in nursing homes: Mini Sarcopenia Risk Assessment full version (MSRA-7) and short version (MSRA-5), SARC-F, and SARC-F combined with calf circumference (SARC-CalF).

Methods: Elderly nursing home residents (aged ≥ 65 years) were recruited. Read More

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December 2018

A new decision tree for diagnosis of osteoarthritis in primary care: international consensus of experts.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Service de rééducation et réadaptation de l'appareil locomoteur et des pathologies du rachis, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, Univ. Paris Descartes, PRES Sorbonne Paris Cité, Hôpital Cochin, Assistance Publique -Hôpitaux de Paris, INSERM UMR-S 1124, UFR Biomédicale des Saints Pères, Paris, France.

Background And Aims: Although osteoarthritis (OA) is managed mainly in primary care, general practitioners (GPs) are not always trained in its diagnosis, which leads to diagnostic delays, unnecessary resource utilization, and suboptimal patient outcomes.

Methods: To address this situation, an International Rheumatologic Board (IRB) of 8 experts from 3 continents developed guidelines for the diagnosis of OA in primary care. The focus was three major topologies: hip, knee, and hand/finger OA. Read More

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December 2018

Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Viale Piazza D'Armi, 1, 28100, Novara, Italy.

Background: Physical exercise and nutrition seem to have a key role in the management of hip fracture patients.

Aim: To evaluate the impact of a 2-month rehabilitative protocol combined with dietetic counseling, with or without essential amino acid supplementation, on functioning in hip fracture patients.

Methods: In this pilot randomized controlled study, we recruited patients aged more than 65 years, at 3 months after hip fracture. Read More

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December 2018

First recognized n-butanol concentration may be simple and useful index for assessing olfactory dysfunction in geriatric patients.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Chung-Ang University College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, 156-755, Republic of Korea.

The KVSSII is widely used to evaluate olfactory function in the Korean population. We evaluated the usefulness of the first recognized n-butanol concentration, which is obtained at the beginning part of KVSS II, in predicting olfactory dysfunction. Three hundred seventy two subjects were enrolled in our study. Read More

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December 2018

Evaluation of age-related differences in anterior cruciate ligament size.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: The purpose of this study was to reveal the relation between age and the morphological characteristics of the anterior cruciate ligament (ACL) using magnetic resonance imaging (MRI).

Methods: Thirty-seven young subjects who were diagnosed with a meniscus injury without ACL tear using MRI (15 male and 22 female, median age 26, range 15-49), and 33 elderly subjects for whom knee MRI was performed before uni-compartmental knee arthroplasty (11 male and 22 female, median age 77, range 60-83), were included in this study. In the elderly group, healthy ACL gross morphology was confirmed macroscopically during surgery. Read More

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December 2018

Mitochondrial health and muscle plasticity after spinal cord injury.

Eur J Appl Physiol 2018 Dec 11. Epub 2018 Dec 11.

James J. Peters VA Medical Center, Bronx, NY, USA.

Mitochondria are responsible for aerobic respiration and large-scale ATP production in almost all cells of the body. Their function is decreased in many neurodegenerative and cardiovascular disease states, in metabolic disorders such as type II diabetes and obesity, and as a normal component of aging. Disuse of skeletal muscle from immobilization or unloading triggers alterations of mitochondrial density and activity. Read More

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December 2018

Gynecologic radiation oncology patients report unmet needs regarding sexual health communication with providers.

J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA.

Purpose: Following radiation therapy (RT), women with gynecologic malignancies report high rates of sexual dysfunction, but little is known regarding sexual health communication between these patients and health-care providers. This study assessed these patients' beliefs/attitudes toward providers' sexual history taking.

Methods: Surveys were administered to women who presented for follow-up care for gynecologic cancers in an academic radiation oncology department. Read More

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December 2018

Manubriosternal joint: synchondrosis or symphysis? Analysis of morphology and aging in humans.

Surg Radiol Anat 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Applied Morphology, LEMA, Department of Morphology, Universidade Federal do Espirito Santo, UFES, Maruipe Avenue, 1468 N, Vitoria, Espirito Santo, 29043-900, Brazil.

Introduction: The uncertainty about the morphological classification of the manubriosternal joint is historical in the field of Anatomy and is still under discussion. This makes it difficult to teach and diagnosing related matters, especially those that require radiological images. In fact, this subject lacks specific data. Read More

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December 2018

[Biomechanical aspects of preoperative planning: What is really important?]

Authors:
F Völlner J Grifka

Orthopade 2018 Dec 11. Epub 2018 Dec 11.

Orthopädische Klinik für die Universität Regensburg, Asklepios Klinikum Bad Abbach, Kaiser-Karl-V-Allee 3, 93077, Bad Abbach, Deutschland.

Background: Sagittal balance is dependent on a complex interplay of the spinal curves, shape and setting of the pelvis, but also the position of the joints of the lower limb. Degenerative processes such as stiffening of the spine, aging of musculature, or reduction of the range of motion of the joints lead to imbalance of the spine after all compensatory mechanisms have been exhausted.

Objectives: Based on standardized imaging, compensation mechanisms must be identified within a biomechanical analysis of the spine, the original sagittal spine profile anticipated and included in the planning of the corrective intervention. Read More

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December 2018
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Toward the Development of SMART Communication Technology: Automating the Analysis of Communicative Trouble and Repair in Dementia.

Innov Aging 2018 Sep 3;2(3):igy034. Epub 2018 Dec 3.

School of Health and Rehabilitation Sciences, Faculty of Health and Behavioural Sciences, University of Queensland, Brisbane, Australia.

Background And Objectives: Communication difficulties have been reported as one of the most stress-inducing aspects of caring for people with dementia. Notably, with disease progression comes an increase in the frequency of communication difficulty and a reduction in the effectiveness of attempts to remedy breakdowns in communication. The aim of the current research was to evaluate the utility of an automated discourse analysis tool (i. Read More

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September 2018

Role of viruses, prions and miRNA in neurodegenerative disorders and dementia.

Virusdisease 2018 Dec 29;29(4):419-433. Epub 2018 Sep 29.

Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National, Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 USA.

Dementia is known as loss of cellular communications in the brain at a region caused by multi-factorial diseases and pathogenic infections. Approximately eighty percent reported cases of Alzheimer's disease are followed by vascular dementia. The common symptoms of dementia include memory loss, concentration problems, thinking, and language solving situations. Read More

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December 2018

Encapsulating Peritoneal Sclerosis in Long-Termed Peritoneal Dialysis Patients.

Biomed Res Int 2018 13;2018:8250589. Epub 2018 Nov 13.

Division of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.

Background: Encapsulating peritoneal sclerosis (EPS) is a rare but serious clinical complication of long-term peritoneal dialysis (PD) patients with high mortality. The purpose of this study was to assess the clinical characteristics of patients with EPS and to search for possible factors useful for EPS prevention and early diagnosis.

Method: This retrospective study was performed in a single dialysis center in Taiwan between August 1990 and April 2014. Read More

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November 2018

Critical Role of Somatosensation in Postural Control Following Spaceflight: Vestibularly Deficient Astronauts Are Not Able to Maintain Upright Stance During Compromised Somatosensation.

Front Physiol 2018 27;9:1680. Epub 2018 Nov 27.

Human Research Program, Johnson Space Center, National Aeronautics and Space Administration, Houston, TX, United States.

The free-fall of orbital spaceflight effectively removes the gravitational vector used as a primary spatial orientation reference on Earth. Sustained absence of this reference drives adaptive changes in the internal perception-action models of the central nervous system (CNS), most notably in the processing of the vestibular otolith inputs. Upon landing, the return of the gravitational signal triggers a re-adaptation that restores terrestrial performance; however, during this period, the individual suffers from a functional vestibular deficiency. Read More

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November 2018

X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging.

Front Aging Neurosci 2018 27;10:394. Epub 2018 Nov 27.

Center for Magnetic Resonance Research (CMRR), Department of Radiology, School of Medicine, University of Minnesota, Minneapolis, MN, United States.

Brain relies on glucose and oxygen metabolisms to generate biochemical energy in the form of adenosine triphosphate (ATP) for supporting electrophysiological activities and neural signaling under resting or working state. Aging is associated with declined mitochondrial functionality and decreased cerebral energy metabolism, and thus, is a major risk factor in developing neurodegenerative diseases including Alzheimer's disease (AD). However, there is an unmet need in the development of novel neuroimaging tools and sensitive biomarkers for detecting abnormal energy metabolism and impaired mitochondrial function, especially in an early stage of the neurodegenerative diseases. Read More

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November 2018

Visual-Somatosensory Integration and Quantitative Gait Performance in Aging.

Front Aging Neurosci 2018 27;10:377. Epub 2018 Nov 27.

Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States.

The ability to integrate information across sensory modalities is an integral aspect of mobility. Yet, the association between visual-somatosensory (VS) integration and gait performance has not been well-established in aging. A total of 333 healthy older adults (mean age 76. Read More

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November 2018

Labor augmentation during birth and later cognitive ability in young adulthood.

Clin Epidemiol 2018 26;10:1765-1772. Epub 2018 Nov 26.

Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark,

Purpose: Synthetic oxytocin for labor augmentation during birth has been linked to negative neurodevelopment effects in children. We examined whether maternal labor augmentation was associated with lower cognitive ability in young adulthoods.

Patients And Methods: We identified 330,107 individuals (96. Read More

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November 2018