2,545 results match your criteria Aging Clinical and Experimental Research[Journal]


Gender differences in the association between physical activity and health-related quality of life among community-dwelling elders.

Aging Clin Exp Res 2020 May 27. Epub 2020 May 27.

Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei City, Taiwan (R.O.C.).

Background: Physical activity can improve health-related quality of life (HRQoL) in older adults. However, the differential effects of gender on quality of life are unclear.

Aims: To determine the association between physical activity and HRQoL in men and women. Read More

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http://dx.doi.org/10.1007/s40520-020-01597-xDOI Listing

The association between polypharmacy and the efficiency of the functional independence measure in an acute-stage hospital: a retrospective cohort study.

Aging Clin Exp Res 2020 May 26. Epub 2020 May 26.

Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1196, Japan.

Background: The Functional Independence Measure (FIM) evaluates the activities of daily living (ADL), and FIM efficiency represents daily improvement in FIM. Polypharmacy affects both ADL and FIM; however, few studies have evaluated its relationship with FIM efficiency.

Aim: This retrospective study investigated the effect of polypharmacy on FIM efficiency in patients undergoing rehabilitation at our acute care hospital in 2014. Read More

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http://dx.doi.org/10.1007/s40520-020-01591-3DOI Listing

Clinicians' and public acceptability of universal risk-of-death screening for older people in routine clinical practice in Australia: cross-sectional surveys.

Aging Clin Exp Res 2020 May 26. Epub 2020 May 26.

Gold Coast Hospital and Health Service, Professorial Unit Level 2, PED Building E, 1 Hospital Boulevard, Southport, QLD, 4215, Australia.

Background: Clinicians' delays to identify risk of death and communicate it to patients nearing the end of life contribute to health-related harm in health services worldwide. This study sought to ascertain doctors, nurses and senior members of the public's perceptions of the routine use of a screening tool to predict risk of death for older people.

Methods: Cross-sectional online, face-to-face and postal survey of 360 clinicians and 497 members of the public. Read More

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http://dx.doi.org/10.1007/s40520-020-01598-wDOI Listing

The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing.

Aging Clin Exp Res 2020 May 26. Epub 2020 May 26.

Upjohn (Division of Pfizer), Surrey, UK.

The early stages of the COVID-19 pandemic have focused on containing SARS-CoV-2 infection and identifying treatment strategies. While controlling this communicable disease is of utmost importance, the long-term effect on individuals with non-communicable diseases (NCD) is significant. Although certain NCDs appear to increase the severity of COVID-19 and mortality risk, SARS-CoV-2 infection in survivors with NCDs may also affect the progression of their pre-existing clinical conditions. Read More

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http://dx.doi.org/10.1007/s40520-020-01601-4DOI Listing

Sample size calculation of clinical trials in geriatric medicine.

Aging Clin Exp Res 2020 May 26. Epub 2020 May 26.

Institute of Clinical Physiology (IFC-CNR), Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension of Reggio Calabria, Ospedali Riuniti, via Vallone Petrara, Reggio Calabria, Italy.

A preliminary step when planning a randomized clinical trial (RCT) is the sample size calculation. This is the determination of the optimal number of patients which ensures an adequate power to the study to detect as statistically significant a certain between-arms difference, if any, in the frequency/magnitude of a specific endpoint. The sample size calculation is performed by specific calculators requiring as input variables the expected effect size, the alpha error (α), the beta error (β) and the allocation ratio, this latter being the ratio between the number of participants allocated to the arms of a RCT. Read More

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http://dx.doi.org/10.1007/s40520-020-01595-zDOI Listing

Verification of the predictive validity for mortality of the SARC-F questionnaire based on a meta-analysis.

Aging Clin Exp Res 2020 May 25. Epub 2020 May 25.

Department of Diabetes and Metabolism, Ise Red Cross Hospital, 1-471-21-chome, Ise-shi, FunaeMie, 516-8512, Japan.

Background: Although the association between SARC-F questionnaire positivity and mortality has previously been studied, the results are inconsistent. Testing the predictive validity of the SARC-F questionnaire for clinically relevant outcomes of vital prognoses is important.

Aim: The objective of this study was to test the predictive validity of SARC-F by conducting a meta-analysis on the association between SARC-F, a screening tool for sarcopenia, and mortality. Read More

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http://dx.doi.org/10.1007/s40520-020-01585-1DOI Listing

Does skeletal muscle morphology or functional performance better explain variance in fast gait speed in older adults?

Aging Clin Exp Res 2020 May 25. Epub 2020 May 25.

School of Kinesiology and Physical Therapy, University of Central Florida, 12805 Pegasus Drive, HPA 1-Room 258, Orlando, FL, 32816-2205, USA.

Background: Fast gait speed is being increasingly recognized as an important clinical tool in older adults. However, the underlying muscular and functional contributors to fast gait speed performance remain poorly understood.

Aim: We sought to determine predictors of fast gait speed in older adults. Read More

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http://dx.doi.org/10.1007/s40520-020-01596-yDOI Listing

A case of cognitive impairment finding solution after the onset of anisocoria.

Aging Clin Exp Res 2020 May 25. Epub 2020 May 25.

Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1007/s40520-020-01599-9DOI Listing

Stay fit, don't quit: Geriatric Exercise Prescription in COVID-19 Pandemic.

Aging Clin Exp Res 2020 May 25. Epub 2020 May 25.

Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia.

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http://dx.doi.org/10.1007/s40520-020-01588-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246219PMC

Frailty status, acute coronary syndrome and all-cause mortality in the elderly.

Aging Clin Exp Res 2020 May 24. Epub 2020 May 24.

The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.

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http://dx.doi.org/10.1007/s40520-020-01593-1DOI Listing

Emergency laparotomy in the older patient: factors predictive of 12-month mortality-Salford-POPS-GS. An observational study.

Aging Clin Exp Res 2020 May 24. Epub 2020 May 24.

General Surgery Department, Salford Royal NHS Foundation Trust, Stott Lane, Salford, Manchester, M6HD8, UK.

Introduction: Although high rates of in-hospital mortality have been described in older patients undergoing emergency laparotomy (EL), less is known about longer-term outcomes in this population. We describe factors present at the time of hospital admission that influence 12-month survival in older patients.

Methods: Observational study of patients aged 75 years and over, who underwent EL at our hospital between 8th September 2014 and 30th March 2017. Read More

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http://dx.doi.org/10.1007/s40520-020-01578-0DOI Listing

Neuromechanical response of the upper body to unexpected perturbations during gait initiation in young and older adults.

Aging Clin Exp Res 2020 May 23. Epub 2020 May 23.

Cardiff Metropolitan University, Cyncoed Campus, Cyncoed Road, Cardiff, CF23 6XD, UK.

Background: Control of upper body motion deteriorates with ageing leading to impaired ability to preserve balance during gait, but little is known on the contribution of the upper body to preserve balance in response to unexpected perturbations during locomotor transitions, such as gait initiation.

Aim: To investigate differences between young and older adults in the ability to modify the trunk kinematics and muscle activity following unexpected waist lateral perturbations during gait initiation.

Methods: Ten young (25 ± 2 years) and ten older adults (73 ± 5 years) initiated locomotion from stance while a lateral pull was randomly applied to the pelvis. Read More

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http://dx.doi.org/10.1007/s40520-020-01592-2DOI Listing

Responsiveness to muscle mass gain following 12 and 24 weeks of resistance training in older women.

Aging Clin Exp Res 2020 May 23. Epub 2020 May 23.

Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Londrina, PR, Brazil.

Background: Many factors may influence the magnitude of individual responses to resistance training (RT). How the manipulation of training volume and frequency affects responsiveness level for muscle mass gain in older women has not been investigated.

Aims: This study had the objective of identifying responders (RP) and non-responders (N-RP) older women for skeletal muscle mass (SMM) gain from a 12-week resistance training (RT) program. Read More

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http://dx.doi.org/10.1007/s40520-020-01587-zDOI Listing

Association of preoperative medication with postoperative length of stay in elderly patients undergoing hip fracture surgery.

Aging Clin Exp Res 2020 May 21. Epub 2020 May 21.

Department of Pharmacy, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Background: For elderly patients who are about to undergo surgery, research on the effects of preoperative medication on postoperative outcomes is rare, especially preoperative discontinuation-requiring medication (PDRM) which needed to be discontinued because of its increased risk of postoperative complications.

Aim: To investigate whether preoperative medication (PDRM and polypharmacy) is associated with postoperative length of hospital stay (LOS) in elderly patients undergoing hip fracture surgery.

Methods: Patients aged ≥ 65 who were scheduled for hip (limited to femoral tuberosity) fracture surgery were included. Read More

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http://dx.doi.org/10.1007/s40520-020-01567-3DOI Listing

Defining the characteristics of intermediate care models including transitional care: an international Delphi study.

Aging Clin Exp Res 2020 May 19. Epub 2020 May 19.

NHS Lanarkshire, Glasgow, Scotland.

Background: Although there is growing utilisation of intermediate care to improve the health and well-being of older adults with complex care needs, there is no international agreement on how it is defined, limiting comparability between studies and reducing the ability to scale effective interventions.

Aim: To identify and define the characteristics of intermediate care models.

Methods: A scoping review, a modified two-round electronic Delphi study involving 27 multi-professional experts from 13 countries, and a virtual consensus meeting were conducted. Read More

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http://dx.doi.org/10.1007/s40520-020-01579-zDOI Listing

Efficacy and tolerability of tapentadol for the treatment of chronic low back pain in elderly patients.

Aging Clin Exp Res 2020 May 16. Epub 2020 May 16.

Anesthesiology and Intensive Medicine, Department of Medicine-DIMED, Padua University, Via Giustiniani 2, 35128, Padua, Italy.

Background: Chronic low back pain (CLBP) is a highly prevalent and disabling condition in the elderly, and yet it is undertreated and understudied in this patient population. Tapentadol is a central analgesic with an improved tolerability profile that may be particularly beneficial to the elderly CLBP.

Methods: We performed an observational retrospective study to comparatively assess the efficacy and tolerability of tapentadol in young and elderly patients with severe CLBP. Read More

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http://dx.doi.org/10.1007/s40520-020-01586-0DOI Listing

Participation in cognitive activities is associated with foot reaction time and gait speed in older adults.

Aging Clin Exp Res 2020 May 15. Epub 2020 May 15.

Department of Nursing, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA.

Background: Given the evidence of the links between cognition and mobility, participation in cognitive activities may benefit neuromotor performance and mobility in older adults.

Aims: To examine the association between participation in cognitive activities and foot reaction time (RT) and gait speed in community-dwelling older adults.

Methods: The MOBILIZE Boston Study II (MBSII) re-enrolled 354 community-dwelling older adults aged ≥ 70 years from the original MBS cohort. Read More

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http://dx.doi.org/10.1007/s40520-020-01583-3DOI Listing

Early cardiac rehabilitation: could it improve functional outcomes and reduce length of stay and sanitary costs in patients aged 75 years or older? A retrospective case-control study.

Aging Clin Exp Res 2020 May 15. Epub 2020 May 15.

Rehabilitation Unit, Rehabilitation Department, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Background: Cardiac rehabilitation (CR) is considered as a cornerstone in improving physical function in older people after cardiac procedures; however, its effects in patients aged more than 75 years are still debated.

Aims: To assess the effectiveness of early CR in improving functional outcomes and reducing the length of stay (LOS) and sanitary costs in patients aged ≥ 75 years.

Methods: We retrospectively analysed data from medical records of patients aged ≥ 75 years performed CR after cardiac procedures. Read More

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http://dx.doi.org/10.1007/s40520-020-01589-xDOI Listing

Age at death in elderly cohorts of four European countries of the Seven Countries Study: the role of comorbidities.

Aging Clin Exp Res 2020 May 14. Epub 2020 May 14.

Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.

Purpose: To study age at death (AD) in elderly men as a function of risk factors and morbid conditions in a 25-year follow-up.

Materials And Methods: Men enrolled in the Seven Countries Study belonging to 8 cohorts in 4 European countries (Finland, The Netherlands, Italy and Serbia) were examined between 1984 and 1989 (aged 65-84 years) with measurement of some cardiovascular risk factors and recording of a few major morbid conditions. AD was measured after 25-year follow-up and used in multiple linear regression (MLR) models as dependent variable; while, risk factors and morbid conditions had the role of independent variables. Read More

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http://dx.doi.org/10.1007/s40520-020-01568-2DOI Listing

Vertebral compression fractures in multiple myeloma: redefining the priorities during the COVID-19 pandemic.

Aging Clin Exp Res 2020 May 14. Epub 2020 May 14.

Orthopedics and Traumatology Unit, Emergency and Urgency Department, A.S.S.T. Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore 3, Milan, Italy.

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http://dx.doi.org/10.1007/s40520-020-01590-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224162PMC

Diaphragmatic muscle thickness in older people with and without sarcopenia.

Aging Clin Exp Res 2020 May 13. Epub 2020 May 13.

Division of Geriatrics, Department of Internal Medicine, School of Medicine, Gazi University, Ankara, Turkey.

Background: Studies in mice have suggested that sarcopenic animals may have atrophic diaphragmatic muscles; however, to date, no clinical studies are available.

Aims: To investigate whether the diaphragmatic thickness is affected in older patients with sarcopenia and if this is associated with impaired respiratory functions.

Methods: Thirty sarcopenic and 30 non-sarcopenic elderly patients aged over 65 were included. Read More

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http://dx.doi.org/10.1007/s40520-020-01565-5DOI Listing

Validation of shock index for predicting mortality in older patients with dengue fever.

Aging Clin Exp Res 2020 May 12. Epub 2020 May 12.

Department of Emergency Medicine, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.

Background: Older adults have a higher mortality for dengue fever (DF). However, the best method for predicting mortality is still unclear.

Aims: We conducted this study to evaluate the shock index (SI) for this issue. Read More

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http://dx.doi.org/10.1007/s40520-020-01563-7DOI Listing

The association between fear of falling and orthostatic hypotension in older adults.

Aging Clin Exp Res 2020 May 11. Epub 2020 May 11.

Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

The aim of this study was to determine the relationship between the fear of falling/the degree of fear of falling (FoF) and orthostatic hypotension (OH) in older adults. This cross-sectional study was conducted with 314 older outpatients. If the total score of the Falls Efficacy Scale-International scale was 16-19, 20-27 and ≥ 28, it was assumed that there was low FoF, moderate FoF and high FoF, respectively. Read More

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http://dx.doi.org/10.1007/s40520-020-01584-2DOI Listing

COVID-19 in older adults.

Aging Clin Exp Res 2020 May 10. Epub 2020 May 10.

Division of Geriatric and Palliative Medicine, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, 593, Eddy Street, POB 438, Providence, USA.

The advent of the SARS-CoV-2 and COVID-19 pandemic has generated a lot of publications at a rapid pace. We know that older adults disproportionately suffer the most severe of COVID outcomes. Here we attempt to coalesce the key knowledge of SARS-CoV-2 biology to the disease and clinical care concepts in the context of older adults. Read More

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http://dx.doi.org/10.1007/s40520-020-01581-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211267PMC

A multifactorial intervention to lower potentially inappropriate medication use in older adults in Argentina.

Aging Clin Exp Res 2020 May 9. Epub 2020 May 9.

Hospital Italiano de Buenos Aires (Internal Medicine Service), Tte. Gral. Juan Domingo Perón 4190 (CP 1199ABB), Buenos Aires, Argentina.

Background: Adverse drug reactions are a common cause of potentially avoidable harm, particularly in older adults.

Aims: To evaluate the feasibility and efficacy of a pilot multifactorial intervention to reduce potentially inappropriate medication (PIM) use in older adults.

Methods: We conducted a phase 2, feasibility, open-label study in the ambulatory setting of an integrated healthcare network in Buenos Aires, Argentina. Read More

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http://dx.doi.org/10.1007/s40520-020-01582-4DOI Listing

The prognostic role of age in primary cutaneous B-cell lymphoma: a proposal derived from a population-based registry.

Aging Clin Exp Res 2020 May 8. Epub 2020 May 8.

Department of Pharmacy, The Second Hospital of Shanxi Medical University, Shanxi, 030001, China.

Purpose: A few prognostic predicting systems existed for primary cutaneous B-cell lymphoma (PCBCL). However, none of them took age into consideration. We sought to declare the prognostic role of age in PCBCL. Read More

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http://dx.doi.org/10.1007/s40520-020-01544-wDOI Listing

Management of heart failure: an Italian national survey on fellows/specialists in geriatrics.

Aging Clin Exp Res 2020 May 7. Epub 2020 May 7.

Area di Geriatria, Università Campus Bio-Medico di Roma, via Alvaro del Portillo 21, 00128, Rome, Italy.

Background: Heart failure (HF) is often managed by geriatricians. Few data are available on their knowledge and attitudes about this condition.

Aims: To compare perceptions and knowledge on HF of specialists/fellows in geriatrics working in Italy. Read More

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http://dx.doi.org/10.1007/s40520-020-01577-1DOI Listing

Electroencephalogram in dementia with Lewy bodies: a systematic review.

Aging Clin Exp Res 2020 May 7. Epub 2020 May 7.

Leeds Teaching Hospitals, Leeds, UK.

Dementia with Lewy bodies (DLB) belongs to the spectrum of Lewy body dementia (LBD) that also encompasses Parkinson's disease dementia (PDD). It is a common neurodegenerative disorder characterized by memory decline, cognitive fluctuations, visual hallucinations, autonomic nervous system disturbance, REM sleep behavior disorder, and parkinsonism. Definite diagnosis can be established only through neuropathological confirmation of Lewy bodies' presence in brain tissue. Read More

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http://dx.doi.org/10.1007/s40520-020-01576-2DOI Listing

Task specificity impacts dual-task interference in older adults.

Aging Clin Exp Res 2020 May 6. Epub 2020 May 6.

Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE, 68182, USA.

Background: Task prioritization is an important factor determines the magnitude and direction of dual-task interference in older adults. Greater dual-task cost during walking may lead to falling, sometimes causing lasting effects on mobility.

Aims: We investigated dual-task interference for walking and cognitive performance. Read More

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http://dx.doi.org/10.1007/s40520-020-01575-3DOI Listing

The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality.

Aging Clin Exp Res 2020 May 6. Epub 2020 May 6.

The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK.

WHO declared SARS-CoV-2 a global pandemic. The present aim was to propose an hypothesis that there is a potential association between mean levels of vitamin D in various countries with cases and mortality caused by COVID-19. The mean levels of vitamin D for 20 European countries and morbidity and mortality caused by COVID-19 were acquired. Read More

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http://dx.doi.org/10.1007/s40520-020-01570-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202265PMC

Coffee consumption and extreme longevity: a risk assessment.

Authors:
Tomoyuki Kawada

Aging Clin Exp Res 2020 May 5. Epub 2020 May 5.

Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo, 113-8602, Japan.

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http://dx.doi.org/10.1007/s40520-020-01569-1DOI Listing

Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project.

Aging Clin Exp Res 2020 May 3. Epub 2020 May 3.

Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Snta Maria Della Misericordia Hospital, Piazzale Gambuli 1, 06132, Perugia, Italy.

Background: Alkaline phosphatase has been found on neuronal membranes and plasma alkaline phosphatase (ALP) activity increases during brain injury and cerebrovascular diseases, suggesting that its levels may reflect the neuronal loss. It is known that ALP is higher in subjects affected by Alzheimer's dementia and inversely correlated with cognitive functions. No study has investigated the relationship between ALP and cognitive functions in old-age subject with pre-clinical cognitive impairment. Read More

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http://dx.doi.org/10.1007/s40520-020-01572-6DOI Listing

Ecological factors associated with Emergency Department use by older people in Italy.

Aging Clin Exp Res 2020 May 2. Epub 2020 May 2.

Geriatria, Accettazione geriatrica e Centro di ricerca per l'invecchiamento, IRCCS INRCA, Ancona, Italy.

Background: Many studies investigated factors associated with overuse of Emergency Department (ED) by older people. However, there is little evidence of how a better access to long-term care services can affect ED visit rates. Therefore, we estimated the association between ED use and contextual (distance to closest ED), need (priority level at admission and care deprivation), predisposing (socio-economic conditions) and enabling factors (availability of health services) at the municipal level. Read More

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http://dx.doi.org/10.1007/s40520-020-01571-7DOI Listing

Minimizing comprehensive geriatric assessment to identify deterioration of physical performance in a healthy community-dwelling older cohort: longitudinal data of the AEQUIPA Versa study.

Aging Clin Exp Res 2020 May 1. Epub 2020 May 1.

Assistive Systems and Medical Device Technology, Department of Health Services Research, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.

Background: It is important to identify the relevant parameters of physical performance to prevent early functional decline and to prolong independent living. The aim of this study is to describe the development of physical performance in a healthy community-dwelling older cohort aged 70+ years using comprehensive assessment over two years and to subsequently identify the most relevant predictive tests for physical decline to minimize assessment.

Methods: Physical performance was measured by comprehensive geriatric assessment. Read More

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http://dx.doi.org/10.1007/s40520-020-01562-8DOI Listing

A National Multicenter Study on overall survival in elderly metastatic castrate-resistant prostate cancer patients treated with Radium-223.

Aging Clin Exp Res 2020 May 1. Epub 2020 May 1.

Department of Radiological Sciences, Oncology and Anatomical Pathology Sapienza, "Sapienza" University of Rome, Rome, Italy.

Background: Radium-223 prolongs overall survival (OS) and delays time to the first symptomatic skeletal events in patients with symptomatic metastatic castration-resistant prostate cancer (mCRPC). There is a lack of evidence on the safety and efficacy of Radium-223 treatment in the very elderly population.

Aims: Aim of this multicentre study is to analyze mCRPC patients treated with Radium-223 in terms of OS and to assess whether there are differences between young and elderly, as well as to verify efficacy and safety in patients ≥ 75 years of age. Read More

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http://dx.doi.org/10.1007/s40520-020-01573-5DOI Listing

Management of hip fracture in the older people: rationale and design of the Italian consensus on the orthogeriatric co-management.

Aging Clin Exp Res 2020 May 1. Epub 2020 May 1.

Geriatric and Gerontology Department, Campus Bio-Medico University of Rome, via Alvaro del Portillo, 200, 00128, Rome, Italy.

Background: Hip fracture (HF) is a burdening health problem in older people. The orthogeriatric approach has been shown to favour functional recovery and reduce mortality, but its implementation in clinical practice cannot rely upon shared management protocols and greatly varies among different healthcare systems. Here, we present the rationale and design of the Italian consensus document on the management of HF in older people. Read More

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http://dx.doi.org/10.1007/s40520-020-01574-4DOI Listing

Volunteer-led physical activity interventions to improve health outcomes for community-dwelling older people: a systematic review.

Aging Clin Exp Res 2020 Apr 30. Epub 2020 Apr 30.

Academic Geriatric Medicine, University of Southampton, Southampton, UK.

Background: Physical activity (PA) is important for older people to maintain functional independence and healthy ageing. There is strong evidence to support the benefits of physical activity interventions on the health outcomes of older adults. Nonetheless, innovative approaches are needed to ensure that these interventions are practical and sustainable. Read More

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http://dx.doi.org/10.1007/s40520-020-01556-6DOI Listing

Approaches to the diagnosis and prevention of frailty.

Aging Clin Exp Res 2020 Apr 30. Epub 2020 Apr 30.

Medicine for Older People, University Hospital Southampton, Mailpoint 63, G Level, West Wing, Tremona Road, Southampton, SO16 6YD, UK.

An individual who is living with frailty has impairments in homeostasis across several body systems and is more vulnerable to stressors that may ultimately predispose them to negative health-related outcomes, disability and increased healthcare use. Approximately a quarter of individuals aged > 85 years are living with frailty and as such the identification of those who are frail is a public health priority. Given that the syndrome of frailty is defined by progressive and gradual loss of physiological reserves there is much scope to attempt to modify the trajectory of the frailty syndrome via physical activity and nutritional interventions. Read More

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http://dx.doi.org/10.1007/s40520-020-01559-3DOI Listing

The modified Healthy Aging Index is associated with mobility limitations and falls in a community-based sample of oldest old.

Aging Clin Exp Res 2020 Apr 30. Epub 2020 Apr 30.

Geriatric Cardiology Department of the Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.

Background And Aims: The Healthy Aging Index (HAI) is useful in capturing the health status of multiple organ systems in older adults. Previous studies have mainly focused on the association of HAI with mortality and disability. We constructed a modified HAI (mHAI) to examine its association with mobility limitations and falls in a community-based sampling of older Chinese adults. Read More

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http://dx.doi.org/10.1007/s40520-020-01560-wDOI Listing

Frailty status, acute coronary syndrome and all-cause mortality in the elderly.

Authors:
Tomoyuki Kawada

Aging Clin Exp Res 2020 Apr 30. Epub 2020 Apr 30.

Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo, 113-8602, Japan.

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http://dx.doi.org/10.1007/s40520-020-01566-4DOI Listing

The role of sarcopenia questionnaires in hospitalized patients with chronic heart failure.

Aging Clin Exp Res 2020 Apr 28. Epub 2020 Apr 28.

Department of Gerontology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Gulou District, Nanjing, 210029, Jiangsu, People's Republic of China.

Objectives: To compare the diagnostic value of the SARC-F, MRSA-7 and MRSA-5 questionnaires in screening for sarcopenia in inpatients with chronic heart failure (CHF).

Patients: A total of 355 CHF patients hospitalized from January 2019 to August 2019 who met the study's selection criteria were included in the analysis.

Measurements: Handgrip strength and gait speed were measured, and bioelectrical impedance analysis (BIA) was used to estimate appendicular skeletal muscle mass. Read More

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http://dx.doi.org/10.1007/s40520-020-01561-9DOI Listing

The effect of mind-body exercise on memory in older adults: a systematic review and meta-analysis.

Aging Clin Exp Res 2020 Apr 23. Epub 2020 Apr 23.

Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Objectives: The current systematic review aims to examine the effect of mind-body exercise on different memory types in the elderly population.

Methods: Four literature databases (Pubmed, Cochrane library, Embase and Sinomed) were searched from inception to March 19, 2019. Randomized controlled trials (RCTs) examining the effect of mind-body exercise on memory in older adults were included. Read More

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http://dx.doi.org/10.1007/s40520-020-01557-5DOI Listing

Impact of kidney transplant morbidity on elderly recipients' outcomes.

Aging Clin Exp Res 2020 Apr 23. Epub 2020 Apr 23.

Liver-Kidney Transplant Unit, Department of Medicine, University of Udine, Udine, Italy.

Background And Aims: Nowadays, advanced age does not represent an absolute contraindication to kidney transplantation (KT). However, aging is frequently associated with multiple comorbidities and lower performance status, making KT candidates less surgically fit. Limited data are available on the impact of KT morbidity on elderly recipients' outcomes. Read More

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http://dx.doi.org/10.1007/s40520-020-01558-4DOI Listing

The role of neurofilament light chain in frontotemporal dementia: a meta-analysis.

Aging Clin Exp Res 2020 Apr 18. Epub 2020 Apr 18.

Leeds Teaching Hospitals, Leeds, UK.

Frontotemporal dementia (FTD) is the second most frequent dementia, after Alzheimer's, in patients under the age of 65. It encompasses clinical entities characterized by behavioral, language, and executive control dysfunction. Neurofilament light chain (NfL) is a new, non-disease specific, widely studied biomarker indicative of axonal injury and degeneration. Read More

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http://dx.doi.org/10.1007/s40520-020-01554-8DOI Listing

Frailty, walking ability and self-rated health in predicting institutionalization: an 18-year follow-up study among Finnish community-dwelling older people.

Aging Clin Exp Res 2020 Apr 18. Epub 2020 Apr 18.

Faculty of Medicine, Department of Clinical Medicine, Unit of Geriatrics, University of Turku, Turku City Hospital, Kunnallissairaalantie 20, 20700, Turku, Finland.

Background: In clinical practice, there is a need for an instrument to screen older people at risk of institutionalization.

Aims: To analyze the association of frailty, walking-ability and self-rated health (SRH) with institutionalization in Finnish community-dwelling older people.

Methods: In this prospective study with 10- and 18-year follow-ups, frailty was assessed using FRAIL Scale (FS) (n = 1087), Frailty Index (FI) (n = 1061) and PRISMA-7 (n = 1055). Read More

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http://dx.doi.org/10.1007/s40520-020-01551-xDOI Listing

Oral diadochokinesis is related to decline in swallowing function among community-dwelling Japanese elderly: a cross-sectional study.

Aging Clin Exp Res 2020 Apr 18. Epub 2020 Apr 18.

Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: Since oral organs function in the first stage of the swallowing process, it is possible that decline in swallowing function can be partly related to oral frailty.

Aims: The purpose of this study was to investigate the association between swallowing function and oral function among community-dwelling elderly Japanese and to propose cut-off values for screening of decline in swallowing function.

Methods: A total of 188 participants were included in the analysis. Read More

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http://dx.doi.org/10.1007/s40520-020-01547-7DOI Listing

Platelet-to-lymphocyte ratio relates to poor prognosis in elderly patients with acute myocardial infarction.

Aging Clin Exp Res 2020 Apr 16. Epub 2020 Apr 16.

Tangshan Gongren Hospital, Tangshan, Hebei, China.

Background: The platelet to lymphocyte ratio (PLR) is a novel biomarker to predict the prognosis of acute myocardial infarction (AMI) patients.

Aim: The study aimed to evaluate the in-hospital outcomes of elderly patients with AMI and assessed the prognostic value of PLR on in-hospital adverse events.

Methods: A total of 1,001 patients were divided into an older group (n = 560) and a younger group (n = 441) based on age ≥ 60 years and successfully underwent primary percutaneous coronary intervention (PCI) within 12 h after presentation. Read More

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http://dx.doi.org/10.1007/s40520-020-01555-7DOI Listing
April 2020
1.138 Impact Factor

The diversity of gut microbiota in type 2 diabetes with or without cognitive impairment.

Aging Clin Exp Res 2020 Apr 16. Epub 2020 Apr 16.

Department of Cardiovascular, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi, 214000, China.

Background: Diabetes is associated with a high risk of developing cognitive impairment, but the underlying mechanism remains unclear. Recent studies have found that gut microbiota may be involved in the progression of diabetes-associated cognitive impairment.

Aims: To analyze the diversity of gut microbiota in type 2 diabetes with or without cognitive impairment METHODS: 16S rRNA sequencing was used to detect the gut microbiota composition in 154 type 2 diabetes (T2DM) subjects RESULTS: Among 154 elderly T2DM participants included in our study, 73 with normal and 81 with impaired cognition. Read More

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http://dx.doi.org/10.1007/s40520-020-01553-9DOI Listing
April 2020
1.138 Impact Factor

Effects of short- and long-term neurostimulation (tDCS) on Alzheimer's disease patients: two randomized studies.

Aging Clin Exp Res 2020 Apr 16. Epub 2020 Apr 16.

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Background: Non-invasive brain stimulation is an effective treatment for Alzheimer's disease.

Aims: The purpose of the two studies presented here is to compare the short- and long-term effects of transcranial direct current stimulation (t-DCS) on two samples of advanced AD patients.

Methods: In Study 1 26 patients were involved in a 10-day anodal vs. Read More

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http://dx.doi.org/10.1007/s40520-020-01546-8DOI Listing