2,150 results match your criteria Aging Clinical and Experimental Research[Journal]


Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao Longevity and Ageing Study.

Aging Clin Exp Res 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Science and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Background And Aims: To explore whether frailty, defined by frailty index (FI), is associated with the risk of elevated B-type natriuretic peptide (BNP), a surrogate endpoint of cardiovascular events.

Methods: Data of 1382 community-dwelling elders who had no documented cardiovascular diseases aged 70-84 years from the ageing arm of the Rugao Longevity and Ageing Study was used. Traditional risk factor index (TI) was constructed using eight established cardiovascular-related risk factors. Read More

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http://link.springer.com/10.1007/s40520-019-01189-4
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http://dx.doi.org/10.1007/s40520-019-01189-4DOI Listing
April 2019
1 Read

Inflammatory biomarkers and frailty among older hospitalized patients: author's response.

Aging Clin Exp Res 2019 Apr 17. Epub 2019 Apr 17.

National Clinical Research Center for Geriatrics, Chengdu, China.

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http://dx.doi.org/10.1007/s40520-019-01198-3DOI Listing
April 2019
1 Read

The association between preoperative fatigue and instrumental activities in daily living with complications and length of hospital stay in patients undergoing colorectal surgery.

Aging Clin Exp Res 2019 Apr 17. Epub 2019 Apr 17.

ACHIEVE Center for Applied Research, University of Applied Sciences Amsterdam, Amsterdam, The Netherlands.

Background: The incidence of colorectal cancer (CRC) is highest among the elderly. An important treatment modality is surgery. After surgery, due to poor functional recovery, some elderly have an increased risk for complications and prolonged length of hospital stay (LOS). Read More

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http://dx.doi.org/10.1007/s40520-019-01199-2DOI Listing

The association between hand grip strength and rehabilitation outcome in post-acute hip fractured patients.

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

Beit Rivka Geriatric Rehabilitation Center, 4 Hachamisha St, 49245, Petach Tikva, Israel.

Purpose: Various factors have been shown to affect the rehabilitation outcome of hip fractured patients. Considering the decrease in muscle mass with aging and its impact on mobility, we hypothesized that a relationship exists between hand grip strength and rehabilitation outcome.

Methods: We retrospectively studied 373 post-hip fracture patients, admitted for rehabilitation. Read More

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http://dx.doi.org/10.1007/s40520-019-01200-yDOI Listing

Relationship between comorbidities and treatment decision-making in elderly hip fracture patients.

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Geriatrics, West China Hospital, Sichuan University, NO. 37 GuoXue Road, Chengdu, 610041, Sichuan, China.

Background: Elderly patients are at a higher risk for hip fracture. Moreover, hospitalized elderly patients with hip fracture are vulnerable to adverse outcomes including higher mortality rate and long-term disability. Treatment decision-making with respect to surgical procedure and perioperative management of these patients is typically challenging owing to the presence of multiple comorbid conditions. Read More

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http://dx.doi.org/10.1007/s40520-019-01134-5DOI Listing

Effects of oxycodone applied for patient-controlled analgesia on postoperative cognitive function in elderly patients undergoing total hip arthroplasty: a randomized controlled clinical trial.

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology, The Third People's Hospital of Chengdu, Southwest Jiao Tong University, No. 82 Qinglong Street, Chengdu, 610031, Sichuan, China.

Background: Postoperative cognitive dysfunction (POCD) is a common complication after orthopedic surgery, which is not conducive to the prognosis of the elderly.

Aims: We performed this study to investigate the effects of oxycodone applied for patient-controlled intravenous analgesia (PCIA) on postoperative cognitive function in elderly patients after total hip arthroplasty (THA).

Methods: Ninety-nine participants were enrolled and allocated into two groups: oxycodone group (group O) and sufentanil group (group S). Read More

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http://dx.doi.org/10.1007/s40520-019-01202-wDOI Listing
April 2019
1.138 Impact Factor

Practical guidance for engaging patients in health research, treatment guidelines and regulatory processes: results of an expert group meeting organized by the World Health Organization (WHO) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium.

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients' needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1007/s40520-019-01193-8DOI Listing

Late presentation of Takayasu arteritis in geriatric patients.

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Internal Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.

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http://link.springer.com/10.1007/s40520-019-01201-x
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http://dx.doi.org/10.1007/s40520-019-01201-xDOI Listing
April 2019
2 Reads

Factors associated with impairment in gait speed in older people with clinically normal gait. A cross-sectional study.

Aging Clin Exp Res 2019 Apr 12. Epub 2019 Apr 12.

Fundación de Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain.

Background: Health professionals commonly use gait speed in the evaluation of functional status in older people. However, only a limited number of studies have assessed gait speed in the absence of disorders of gait, using confounding factors and exclusion criteria coming from studies conducted in younger people. Our study aims to analyse which factors are associated with gait speed in older people with normal clinical gait. Read More

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http://link.springer.com/10.1007/s40520-019-01187-6
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http://dx.doi.org/10.1007/s40520-019-01187-6DOI Listing
April 2019
3 Reads

Nutrition, osteoarthritis and cartilage metabolism.

Aging Clin Exp Res 2019 Apr 13. Epub 2019 Apr 13.

Centro de Diagnóstico de Osteoporosis y Enfermedades Reumáticas (CEDOR), Lima, Peru.

Background: Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some relief but they do not affect the progression of the disease. Read More

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http://link.springer.com/10.1007/s40520-019-01191-w
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http://dx.doi.org/10.1007/s40520-019-01191-wDOI Listing
April 2019
7 Reads

Analysis of mitochondrial DNA allelic changes in Parkinson's disease: a preliminary study.

Aging Clin Exp Res 2019 Apr 13. Epub 2019 Apr 13.

Center for Neurobiology of Aging, IRCCS INRCA, Via Birarelli 8, 60121, Ancona, Italy.

Background: Mitochondrial DNA (mtDNA) mutations are considered as a possible primary cause of age-associated neurodegenerative disorders like Parkinson's disease (PD).

Aims: To analyze, along the whole mtDNA sequence of PD patients, the presence of non-reference alleles compared to reference alleles, as defined in the revised Cambridge Reference Sequence (rCRS).

Methods: mtDNA was extracted from whole blood of PD and control groups, and was sequenced using a chip-based resequencing system. Read More

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http://dx.doi.org/10.1007/s40520-019-01197-4DOI Listing
April 2019
9 Reads

Feasibility of a tailored ERAS programme in octogenarian patients undergoing minimally invasive surgery for colorectal cancer.

Aging Clin Exp Res 2019 Apr 13. Epub 2019 Apr 13.

Department of General Surgery, Sesto San Giovanni Hospital, Milan, Italy.

Background: The enhanced recovery after surgery (ERAS) is nowadays a widely accepted multimodal programme of care in colorectal surgery, but still there is some reluctance in its application to very elderly patients.

Aim: The aim of this study is to investigate short-term outcomes of laparoscopic resection for colorectal cancer in octogenarian patients within the ERAS programme.

Methods: Data on 162 consecutive patients aged ≥ 80 years receiving elective minimally invasive colorectal resections within ERAS programme were collected in a multicentre, retrospective database in the period 2008-2017 in Italy. Read More

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http://dx.doi.org/10.1007/s40520-019-01195-6DOI Listing

Effects of dance intervention on global cognition, executive function and memory of older adults: a meta-analysis and systematic review.

Aging Clin Exp Res 2019 Apr 13. Epub 2019 Apr 13.

School of Nursing, Jilin University, 965 XinJiang Road, Changchun, 130021, China.

Objective: To summarize and assess the effects of dance intervention on global cognition, executive function and memory in older adults.

Methods: We searched the databases PubMed, Web of Science, Cochrane Library, EMBASE, Clinical Trials.Gov and four Chinese databases (CNKI, CBM, Wan Fang Data and VIP) to identify articles written in English or Chinese and published until April 2018. Read More

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http://dx.doi.org/10.1007/s40520-019-01159-wDOI Listing

Muscle endocrinology and its relation with nutrition.

Aging Clin Exp Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy.

Recent years have demonstrated clear evidence that skeletal muscle is an active endocrine organ. During contraction of muscle fibers, the skeletal muscle produces and releases, into the blood stream, cytokines and other peptides, called myokines, thanks to which it can both communicate with cells locally within the muscle, in an autocrine and paracrine fashion, or with other distant tissues, exerting its endocrine effects. With the progress of sophisticated technologies, the interest towards the skeletal muscle secretome is rapidly grown and the discovery of new myokines represents a prolific field for the identification of new pharmacological approaches for the management and treatment of many clinical diseases. Read More

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http://dx.doi.org/10.1007/s40520-019-01188-5DOI Listing

Preliminary investigation of predictors of distress in informal caregivers of patients with delirium superimposed on dementia.

Aging Clin Exp Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Rehabilitation, Fondazione Camplani Casa di Cura "Ancelle della Carità", Via Aselli 16, 26100, Cremona, Italy.

Objective: Delirium superimposed on dementia (DSD) is common and associated with adverse outcomes. Current evidence indicates that some patients with dementia may recall delirium with distress for them and their caregivers. The aim of this study is to identify predictors of distress in informal caregivers of older patient with DSD. Read More

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http://dx.doi.org/10.1007/s40520-019-01194-7DOI Listing
April 2019
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Prognostic factors that modify outcomes of vestibular rehabilitation in elderly patients with falls.

Aging Clin Exp Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Otolaryngology, Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.

Background: Our previous study has shown that vestibular rehabilitation (VR) is an effective technique to reduce falls in elderly patients. It would be interesting to establish patients' clinical characteristics in which vestibular rehabilitation is expected to be more effective.

Aims: Evaluate factors that could modify rehabilitation outcomes in elderly patients with previous falls. Read More

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http://dx.doi.org/10.1007/s40520-019-01185-8DOI Listing

Measuring physical performance in highly active older adults: associations with age and gender?

Aging Clin Exp Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Interdisciplinary Health Sciences, Institute of Health and Society, University of Oslo, P.O. Box 1089, Blindern, 0317, Oslo, Norway.

Background: Higher age is associated with reduced physical capability in the general population. The role of age and gender for physical performance in older adults who exercises regularly is, however, not clear, and there is also a lack of recommendations for outcomes to address physical performance for this population.

Aims: To explore the associations between physical performance, age and gender, and to examine the suitability and feasibility of clinical field tests for physical performance in active older adults. Read More

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http://dx.doi.org/10.1007/s40520-019-01190-xDOI Listing

Betwixt and between: a surgical post-acute treatment unit (SPA) for the optimal care of elderly patients with isolated hip fractures.

Aging Clin Exp Res 2019 Jan 30. Epub 2019 Jan 30.

Department of Nursing, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY, 11554, USA.

Background: A performance improved project identified elderly trauma patients to have a disproportionate incidence of complications.

Aims: The purpose of this study was to assess the efficacy of a small specialty care unit to decrease complications in patients who no longer warrant care in an intensive care unit (ICU).

Methods: A surgical post-acute treatment unit (SPA) was developed with focused attention to cognition, nutrition, respiration, and mobilization needs of patients who no longer had physiologic need for an intensive care unit environment, but were still in need of increased attention at the bedside. Read More

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http://dx.doi.org/10.1007/s40520-019-01119-4DOI Listing
January 2019
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Comprehensive geriatric assessment in primary care: a systematic review.

Aging Clin Exp Res 2019 Apr 9. Epub 2019 Apr 9.

Academic Geriatric Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.

Background: Comprehensive geriatric assessment (CGA) involves the multidimensional assessment and management of an older person. It is well described in hospital and home-based settings. A novel approach could be to perform CGA within primary healthcare, the initial community located healthcare setting for patients, improving accessibility to a co-located multidisciplinary team. Read More

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http://dx.doi.org/10.1007/s40520-019-01183-wDOI Listing
April 2019
5 Reads

Quantified pre-operative neurological dysfunction predicts outcome after coronary artery bypass surgery.

Aging Clin Exp Res 2019 Apr 8. Epub 2019 Apr 8.

Centre for Neuroscience Studies, Queen's University, 99 University Ave, Kingston, Canada.

Aims: Patients undergoing coronary artery bypass grafting (CABG) surgery may experience neurological impairment. We examined whether intraoperative regional cerebral oxygen saturation (rSO) and neurological dysfunction prior to surgery, measured by robotic technology, are important predictors of post-operative performance following CABG surgery.

Methods: Adult patients undergoing CABG surgery were recruited for this single-center prospective observational study. Read More

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http://dx.doi.org/10.1007/s40520-019-01184-9DOI Listing
April 2019
2 Reads

Association between dietary nutrient intake and sarcopenia in the SarcoPhAge study.

Aging Clin Exp Res 2019 Apr 6. Epub 2019 Apr 6.

Department of Public Health, Epidemiology and Health Economics, University of Liège, Avenue Hippocrate 13, CHU Bât B23, 4000, Liège, Belgium.

Background: It has been suggested that a balanced nutritional intake may be useful in preventing or even reversing sarcopenia.

Aim: To describe cross-sectional associations between dietary nutrient intake and sarcopenia.

Methods: Subjects recruited from the SarcoPhAge study population completed a food frequency questionnaire. Read More

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http://dx.doi.org/10.1007/s40520-019-01186-7DOI Listing
April 2019
2 Reads

Older persons with signs of frailty in a home-based physical exercise intervention: baseline characteristics of an RCT.

Aging Clin Exp Res 2019 Apr 2. Epub 2019 Apr 2.

Rehabilitation, South Karelia Social and Health Care District, Valto Käkelän katu 3, 53130, Lappeenranta, Finland.

Background: Increasing the level of physical activity among persons with signs of frailty improves physical functioning. There is a lack of long-term supervised physical exercise intervention studies including a validated definition of frailty.

Aims: To present baseline characteristics of persons with signs of frailty participating in a randomized long-term home-based physical exercise trial (HIPFRA), and to study associations between the severity of frailty, functional independence and health-related quality-of-life (HRQoL). Read More

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http://dx.doi.org/10.1007/s40520-019-01180-zDOI Listing
April 2019
3 Reads

Basic guide for the application of the main variables of resistance training in elderly.

Aging Clin Exp Res 2019 Mar 30. Epub 2019 Mar 30.

Department of Physical Education, Ceuma University, Rua Josué Montello, 1 Renascença II, São Luís, MA, 65075-120, Brazil.

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http://dx.doi.org/10.1007/s40520-019-01181-yDOI Listing

Prevalence and associated factors of poor sleep quality among Chinese older adults living in a rural area: a population-based study.

Aging Clin Exp Res 2019 Mar 27. Epub 2019 Mar 27.

Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University, No. 324 Jingwuweiqi Road, Jinan, 250021, Shandong, People's Republic of China.

Objective: To investigate the prevalence and associated factors of poor sleep quality among community-dwelling elderly population in a rural area of Northern China.

Methods: We conducted a cross-sectional survey in August-December 2014 and recruited 2195 participants who were aged 65 years or older and living in Yanlou Town of Yanggu County in western Shandong Province, China. Data on demographics, health-related behaviors, and clinical conditions were collected through structured interviews. Read More

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http://link.springer.com/10.1007/s40520-019-01171-0
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http://dx.doi.org/10.1007/s40520-019-01171-0DOI Listing
March 2019
4 Reads
1.138 Impact Factor

Clinical, functional, mental and social profile of the Nicoya Peninsula centenarians, Costa Rica, 2017.

Aging Clin Exp Res 2019 Mar 27. Epub 2019 Mar 27.

Faculty of Medicine, University of Costa Rica, San José, Costa Rica.

Background: In Latin America, knowledge about the demography and health status of adults aged 100 years and over is scarce. Insufficient studies of the elderly population in Costa Rica exist despite having a "Blue Zone" (geographical area with a high concentration of centenarians) in the Peninsula of Nicoya, with a high percentage of centenarians in the districts of Santa Cruz, Nicoya, Hojancha, Nandayure and Carrillo.

Aims: To describe the clinical, functional, mental and social profile of centenarians residing in the Blue Zone of the Peninsula of Nicoya, Costa Rica. Read More

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http://dx.doi.org/10.1007/s40520-019-01176-9DOI Listing
March 2019
1 Read

Supplemental calcium intake in the aging individual: implications on skeletal and cardiovascular health.

Aging Clin Exp Res 2019 Mar 26. Epub 2019 Mar 26.

Division of Endocrinology and Diabetes, Medanta-The Medicity, Gurgaon, New Delhi, India.

Adequate calcium intake during childhood is necessary to achieve optimal peak bone mass and this has the potential by increasing bone reserves, to modulate the rate of age-associated bone loss. However, data regarding the efficacy of calcium obtained either through the diet or in the form of medicinal supplementation, for prevention of bone loss and osteoporotic fractures in the elderly is conflicting. Calcium alone is unlikely to be of benefit for this purpose though the co-administration of calcium and vitamin D may have modest fracture risk benefits. Read More

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http://dx.doi.org/10.1007/s40520-019-01150-5DOI Listing
March 2019
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The prognostic significance of geriatric syndromes and resources.

Aging Clin Exp Res 2019 Mar 25. Epub 2019 Mar 25.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Background: Geriatric syndromes (GS) do not fit into discrete disease categories and are often underdiagnosed in hospitalized older adults. Geriatric resources (GR) are also not routinely collected in clinical settings, although this may potentiate the beneficial effects of clinical decisions. The prognostic relevance of GS and GR has never been systematically evaluated through clinical tools developed for clinical decision purposes. Read More

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http://link.springer.com/10.1007/s40520-019-01168-9
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http://dx.doi.org/10.1007/s40520-019-01168-9DOI Listing
March 2019
3 Reads

Methodological aspects in studies involving high-intensity interval training.

Aging Clin Exp Res 2019 Mar 22. Epub 2019 Mar 22.

Physical Education Department, University Center of Maringá (UNICESUMAR), Maringá, Brazil.

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http://dx.doi.org/10.1007/s40520-019-01179-6DOI Listing

The effects of calorie restriction, intermittent fasting and vegetarian diets on bone health.

Aging Clin Exp Res 2019 Mar 22. Epub 2019 Mar 22.

Department of Public Health, Epidemiology and Health Economics, University of Liege, CHU Sart Tilman B23, 4000, Liège, Belgium.

Uncountable health care organizations, clinicians, and individuals are striving to prevent obesity and the many chronic medical conditions linked to it by advocating a healthy lifestyle that includes measures such as reducing dietary calorie intake (i.e., calorie restriction = CR and intermittent fasting = IF) or limiting/abolishing animal source foods (i. Read More

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http://dx.doi.org/10.1007/s40520-019-01174-xDOI Listing
March 2019
1 Read

Impact of osteoarthritis on activities of daily living: does joint site matter?

Aging Clin Exp Res 2019 Mar 21. Epub 2019 Mar 21.

MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK.

Background: We consider the relationships between a clinical and radiological diagnosis of knee or hip OA and activities of daily-living (ADL) in older adults.

Methods: Data were available for 222 men and 221 women from the Hertfordshire Cohort Study (HCS) who also participated in the UK component of the European Project on Osteoarthritis (EPOSA). Participants completed the EuroQoL survey where they reported if they had difficulties with mobility, self-care, usual activities and movement around their house. Read More

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http://dx.doi.org/10.1007/s40520-019-01163-0DOI Listing
March 2019
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Factors associated with refusal or acceptance of older patients (≥ 65 years) to provide consent to participate in clinical research in cardiology: a qualitative study.

Aging Clin Exp Res 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiology, University Hospital Jean Minjoz, EA3920, University of Franche-Comté, 3 Boulevard Fleming, 25000, Besançon, France.

Background: Clinical research is an essential step in the successful translation of knowledge from basic research into concrete clinical applications, yet many people are reluctant to provide consent when actually approached to actively participate in clinical trials.

Aims: We investigated the factors that influence older patient's (≥ 65 years) decisions to accept or refuse to participate in a prospective randomized clinical trial in secondary prevention after acute coronary syndrome.

Methods: Qualitative approach based on individual semi-structured interviews with patients who were approached for consent to participate in a currently ongoing clinical trial was adopted. Read More

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http://link.springer.com/10.1007/s40520-019-01172-z
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http://dx.doi.org/10.1007/s40520-019-01172-zDOI Listing
March 2019
7 Reads

Cross-cultural adaptation and validation of the Groningen Frailty Indicator in Chinese nursing home residents.

Aging Clin Exp Res 2019 Mar 21. Epub 2019 Mar 21.

School of Nursing, Jilin University, 965 Xinjiang street, Changchun, China.

Background: Frail older people are more likely to develop negative health outcomes. Previous studies have indicated that the Groningen Frailty Indicator is a practical frailty screening instrument with good psychometric properties; however, it has never been implemented in Chinese nursing homes.

Aims: To cross-culturally adapt and validate the Groningen Frailty Indicator in Chinese nursing home residents. Read More

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http://dx.doi.org/10.1007/s40520-019-01178-7DOI Listing
March 2019
1 Read

Heavy metal intoxication and amyotrophic lateral sclerosis: causal or casual relationship?

Aging Clin Exp Res 2019 Mar 21. Epub 2019 Mar 21.

IRCCS Centro Neurolesi "Bonino Pulejo", S.S. 113, Contrada Casazza, 98124, Messina, Italy.

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http://dx.doi.org/10.1007/s40520-019-01177-8DOI Listing
March 2019
2 Reads

Single-bed rooms in a geriatric ward prevent delirium in older patients.

Aging Clin Exp Res 2019 Mar 21. Epub 2019 Mar 21.

Department of Geriatrics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark.

Background: Few studies have investigated treatment environment risk factors for delirium in geriatric patients. In March 2017, a geriatric department was moved from old hospital buildings with multiple-bed rooms (old wards) to a new hospital with single-bed rooms (new wards), with no changes regarding uptake area, staff and admission criteria.

Aims: The aim of this study was to investigate the risk of delirium among patients in single-bed rooms compared with multiple-bed rooms. Read More

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http://link.springer.com/10.1007/s40520-019-01173-y
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http://dx.doi.org/10.1007/s40520-019-01173-yDOI Listing
March 2019
3 Reads

Functional recovery in hip fracture patients: the role of pharmacotherapy.

Aging Clin Exp Res 2019 Mar 21. Epub 2019 Mar 21.

Operative Unit for Recovery and Functional Rehabilitation of the Institute of Castel Goffredo, Istituti Clinici Scientifici Maugeri IRCCS, Mantova, Italy.

Background And Aim: The aim of this prospective observational cohort study was to verify the relationship between number of drugs used and functional outcome in hip fracture patients undergoing rehabilitation.

Methods: This study was conducted on 139 patients with hip fracture who underwent a rehabilitation program. Efficiency rate in the Functional Independence Measure (FIM) and Berg Balance Scale (BBS), and length of stay (LOS) were the outcome measures. Read More

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http://dx.doi.org/10.1007/s40520-019-01175-wDOI Listing
March 2019
1 Read

Untangling the relationship between fat distribution, nutritional status and Parkinson's disease severity.

Aging Clin Exp Res 2019 Mar 15. Epub 2019 Mar 15.

Department of Geriatrics, Centro di Medicina dell'Invecchiamento, Università Cattolica del Sacro Cuore di Roma and IRCCS Fondazione Policlinico "A. Gemelli", Rome, Italy.

Background: Parkinson's disease (PD) is responsible for significant changes in body composition.

Aims: We aimed to test the association between PD severity and fat distribution patterns, and to investigate the potential modifier effect of nutritional status in this association.

Methods: We enrolled 195 PD subjects consecutively admitted to a university geriatric day hospital. Read More

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http://dx.doi.org/10.1007/s40520-019-01166-xDOI Listing

Factors associated with hospitalization for community-acquired pneumonia in home health care patients in Taiwan.

Aging Clin Exp Res 2019 Mar 14. Epub 2019 Mar 14.

The Department of Family Medicine, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Zhongshan Dist., Taipei, 104, Taiwan, ROC.

Background: Pneumonia is a leading cause of hospitalization and death worldwide. However, studies focusing on risk factors of community-acquired pneumonia (CAP) in the home health care (HHC) population remain scarce.

Aims: This study aimed to evaluate risk factors associated with hospitalization for CAP among HHC patients in Taiwan. Read More

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http://dx.doi.org/10.1007/s40520-019-01169-8DOI Listing
March 2019
2 Reads

Psychological markers of longevity in Sardinian centenarians: the impact of developmental factors and social desirability.

Aging Clin Exp Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Pedagogy, Psychology, Philosophy, University of Cagliari, Via Is Mirrionis 1, 09123, Cagliari, Italy.

A body of research documented that the study of mental health of the oldest individuals may contribute to understand the psychological characteristics of longevity. This study had two related aims. First, to fully characterize the psychological health of Sardinian elders in the very late adult span. Read More

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http://dx.doi.org/10.1007/s40520-019-01157-yDOI Listing
March 2019
1 Read

A systematic review and meta-analysis of the associations of vitamin D receptor genetic variants with two types of most common neurodegenerative disorders.

Aging Clin Exp Res 2019 Mar 12. Epub 2019 Mar 12.

Department of Spinal Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, 710054, China.

Background: Whether vitamin D receptor (VDR) genetic variants influence individual susceptibility to neurodegenerative disorders remains controversial.

Aims: This meta-analysis was conducted to analyze correlations of VDR genetic variants with two types of most common neurodegenerative disorders, Parkinson's disease (PD) and Alzheimer's disease (AD).

Methods: Systematic literature research of PubMed and Embase was performed to identify eligible articles. Read More

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http://dx.doi.org/10.1007/s40520-019-01135-4DOI Listing

The Mediterranean diet: a pathway to successful aging.

Aging Clin Exp Res 2019 Mar 11. Epub 2019 Mar 11.

Department of Medical and Surgical Science, School of Medicine, University of Foggia, Foggia, Italy.

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http://dx.doi.org/10.1007/s40520-019-01160-3DOI Listing

Latin American Adult Immunisation Advocacy Summit: Overcoming regional barriers to adult vaccination.

Aging Clin Exp Res 2019 Mar 11;31(3):339-344. Epub 2019 Mar 11.

International Federation on Ageing, 1 Bridgepoint Drive, Suite G. 238, Toronto, ON, M4M 2B4, Canada.

Older adults in Latin America are at an increased risk of hospitalisation, ill health, catastrophic disability and death due to vaccine-preventable diseases such as influenza, herpes zoster, and pneumonia. The Latin American Adult Immunisation Advocacy Summit, held in Mexico City, gathered 40 experts in health, ageing and immunisation from 12 Latin American countries to explore good practices of adult vaccination, key country and regional barriers, and strategies to overcome these barriers. The Summit comprised of introductory lectures, plenary panels and breakout sessions with the overarching goal of improving adult vaccination uptake rates throughout the region. Read More

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http://link.springer.com/10.1007/s40520-019-01156-z
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http://dx.doi.org/10.1007/s40520-019-01156-zDOI Listing
March 2019
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When an "Active Call" can be a "Wake-up Call".

Aging Clin Exp Res 2019 Mar;31(3):299-300

University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1007/s40520-019-01165-yDOI Listing

Comparative effects of fentanyl versus sufentanil on cerebral oxygen saturation and postoperative cognitive function in elderly patients undergoing open surgery.

Aging Clin Exp Res 2019 Mar 7. Epub 2019 Mar 7.

Department of Anesthesia, The Second People's Hospital of Hefei, The Affiliated Hefei Hospital of Anhui Medical University, No 246 Heping Road, Yaohai District, Hefei, 230011, Anhui, China.

This study was aimed to systematically evaluate the effects of fentanyl and sufentanil on intraoperative cerebral oxygen saturation changes and postoperative cognitive function in elderly patients undergoing open surgery. Ninety-six elderly patients who had undergone open surgery under general anesthesia were randomly divided into fentanyl group (F group, anesthesia by fentanyl, 4 g/kg) and sufentanil group (S group, anesthesia by sufentanil, 0.4 µg/kg). Read More

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http://dx.doi.org/10.1007/s40520-019-01123-8DOI Listing
March 2019
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Impact of frailty status on the cost of drugs and dietary supplements prescribed to nursing home residents: the SENIOR cohort.

Aging Clin Exp Res 2019 Mar 7. Epub 2019 Mar 7.

Department of Public Health, Epidemiology and Health Economics, University of Liège, CHU Sart-Tilman, B23, Quartier Hôpital, Avenue Hippocrate, 13, 4000, Liège, Belgium.

Background: The financial impact associated with drug consumption has been poorly investigated among frail subjects and, specifically, in nursing home settings.

Aims: To determine the association of the average monthly cost of the drugs and dietary supplements consumed by nursing home residents with their frailty status.

Methods: This is an analysis of the first follow-up year of the SENIOR cohort. Read More

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http://dx.doi.org/10.1007/s40520-019-01162-1DOI Listing

Development of a German version of the Oral Health Assessment Tool.

Aging Clin Exp Res 2019 Mar 7. Epub 2019 Mar 7.

Dental School, Department of Prosthodontics, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Limited assessment tools for estimating the oral health of nursing home residents are available in the German language.

Aims: To develop a German version of the Oral Health Assessment Tool (OHAT) and to evaluate test-retest and inter-examiner reliability in use for the assessment of nursing home residents' oral health by caregivers before and after dental training.

Methods: The original English version of the OHAT was translated into German by a forward-backward translation process. Read More

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http://dx.doi.org/10.1007/s40520-019-01158-xDOI Listing

Counting deficits or diseases? The agreement between frailty and multimorbidity in subjects with cognitive disturbances.

Aging Clin Exp Res 2019 Mar 6. Epub 2019 Mar 6.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

In the present study, we explored the relationship between multimorbidity and frailty in a population of older individuals with cognitive disturbances attending a memory clinic. All subjects consecutively attending the Memory Clinic of the Department of Human Neuroscience, "Sapienza" University of Rome, between January 2017 and April 2018 for a first neurological evaluation were considered for the present analysis. Multimorbidity was defined as the simultaneous presence of two or more diseases in the same individual. Read More

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http://dx.doi.org/10.1007/s40520-019-01161-2DOI Listing
March 2019
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Characteristics of radiographic morphometries of the lower leg in subjects with progression of knee osteoarthritis in the TOEI cohort.

Aging Clin Exp Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.

Background: Knee osteoarthritis is one of the most common orthopedic diseases. However, few studies have reported the morphometric characteristics of the lower leg related to the progression of knee osteoarthritis in regional populations. This study aimed to determine the radiographic morphometries of the lower leg in subjects who showed progression of osteoarthritis of the knee in the TOEI cohort. Read More

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http://link.springer.com/10.1007/s40520-019-01164-z
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http://dx.doi.org/10.1007/s40520-019-01164-zDOI Listing
March 2019
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Inflammatory biomarkers and frailty among older hospitalized patients.

Authors:
Tomoyuki Kawada

Aging Clin Exp Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, 113-8602, Tokyo, Japan.

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http://dx.doi.org/10.1007/s40520-019-01167-wDOI Listing

Long-term strength and balance training in prevention of decline in muscle strength and mobility in older adults.

Aging Clin Exp Res 2019 Mar 4. Epub 2019 Mar 4.

Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland.

Background: Reductions in muscle strength and poor balance may lead to mobility limitations in older age.

Aims: We assessed the effects of long-term once-weekly strength and balance training (SBT) on muscle strength and physical functioning in a community-based sample of older adults.

Methods: 182 individuals [130 women and 52 men, mean age 80 (SD ± 3. Read More

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http://dx.doi.org/10.1007/s40520-019-01155-0DOI Listing

Muscle adaptation in response to a high-intensity interval training in obese older adults: effect of daily protein intake distribution.

Aging Clin Exp Res 2019 Feb 26. Epub 2019 Feb 26.

Département des Sciences de l'activité physique, Faculté des Sciences, UQAM, Groupe de Recherche en Activité Physique Adaptée (GRAPA), Université du Québec à Montréal, Pavillon Sciences Biologiques, SB-4615, 141, Avenue du Président Kennedy, Montréal, QC, H2X 1Y4, Canada.

Background: Aging is associated with declines in muscle mass, strength and quality, leading to physical impairments. An even protein distribution in daily meals has recently been proposed along with adequate total protein intake as important modulators of muscle mass. In addition, due to its short duration, high-intensity interval training (HIIT) has been highlighted as a promising intervention to prevent physical deterioration. Read More

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http://dx.doi.org/10.1007/s40520-019-01149-yDOI Listing
February 2019