394,727 results match your criteria Aging Clinical and Experimental Research[Journal]


[Implementation of telemedicine in daily care of urological patients].

Aktuelle Urol 2018 Dec 6;49(6):509-514. Epub 2018 Dec 6.

Universitätsklinikum Köln, Klinik für Urologie, Uro-Onkologie, spezielle urologische und roboter-assistierte Chirurgie, Köln.

Due to demographic changes and aging in the German population combined with the shortage of doctors, new techniques are needed to ensure urological patient care in the future. Telemedicine offers great potential to facilitate patient monitoring in their familiar surroundings and to ameliorate patient's compliance with the suggested therapy concept. Through optimal and reliable transfer of patient data, telemedicine helps to optimise patient satisfaction with urological therapies, binds them to their doctor and raises diagnostic safety. Read More

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December 2018
3 Reads

Prevalence and correlates of physical inactivity among older adults in Malaysia: Findings from the National Health and Morbidity Survey (NHMS) 2015.

Arch Gerontol Geriatr 2018 Nov 26;81:74-83. Epub 2018 Nov 26.

Centre for Epidemiology and Evidence Based Practice, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Malaysia has an increasingly aging population. Despite the substantial benefits of physical activity for healthy aging, older adults are considered the most physically inactive segment of the Malaysian population. The purpose of this study was to determine the prevalence of physical inactivity among older adults in Malaysia and its correlates. Read More

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November 2018
2 Reads

Loss of enzyme activity in mutated B4GALNT1 gene products in patients with hereditary spastic paraplegia results in relatively mild neurological disorders: Similarity with phenotypes of B4galnt1 knockout mice.

Neuroscience 2018 Dec 3. Epub 2018 Dec 3.

Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487-8501, Japan; Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466-0065, Japan. Electronic address:

B4GALNT1 is an enzyme essential for the synthesis of complex gangliosides, whose absence leads to progressive neurodegeneration with aging in mice. Recently, eleven cases of hereditary spastic paraplegia with mutation in the coding region of B4GALNT1 were reported. However, changes in the enzymatic activity of their products have never been studied. Read More

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December 2018
2 Reads

Does Maternal Age at Retrieval Influence the Implantation Potential of Euploid Blastocysts?

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10021.

Background: Age-related decline in reproductive potential is mainly due to the increased incidence of aneuploidy. Furthermore, two recent studies have shown that euploid embryos of older women may have a lower implantation potential compared to those of younger women, suggesting that aging might compromise embryos beyond their ploidy status. However, the inherent limitations of these studies preclude solid conclusions. Read More

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December 2018
2 Reads

Amyloid-degrading enzymes in Alzheimer´s disease: from molecules to genetic therapy

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):387-394. Epub 2018 Nov 30.

Universidad Autónoma de Campeche, Facultad de Ciencias Químico Biológicas, Cuerpo Académico Ciencias de la Salud y Biotecnología. Campeche, Campeche, México

Alzheimer’s disease (AD) is the main form of dementia in elderly population worldwide. By 2010 it was estimated that 35.6 million of people were living with this disease, and it was projected that this figure will triple by the year 2050. Read More

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November 2018
2 Reads

Association of colorectal polyps and cancer with low-dose persistent organic pollutants: A case-control study.

PLoS One 2018 6;13(12):e0208546. Epub 2018 Dec 6.

Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: Low-dose persistent organic pollutants (POPs) have recently been linked to immunosenescence, a key mechanism in carcinogenesis, as well as many aging-related chronic diseases. Since feces are the main excretion route of POPs, the large intestine is a potential target organ for these pollutants. We performed a case-control study to evaluate whether exposure to low-dose POPs is related to the risk of colorectal polyps and cancer. Read More

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December 2018

Molecular insights into vascular aging.

Aging (Albany NY) 2018 Dec 5. Epub 2018 Dec 5.

Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge, UK.

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December 2018

Aging, inhibition and GABA.

Aging (Albany NY) 2018 Dec 5. Epub 2018 Dec 5.

KU Leuven, Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, Leuven 3001, Belgium.

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December 2018
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Low-value care: antipsychotic medication use among community-dwelling medicare beneficiaries with Alzheimer's disease and related dementias and without severe mental illness.

Aging Ment Health 2018 Dec 6:1-7. Epub 2018 Dec 6.

a Department of Pharmaceutical Systems and Policy , West Virginia University , Morgantown , WV , USA.

Background: Antipsychotic medication use among elderly with Alzheimer's disease and related dementias (ADRD) and without severe mental illness is considered as low-value care. Our objective was to assess the factors associated with this inappropriate use of antipsychotic medications among community-dwelling Medicare beneficiaries with ADRD and without severe mental illness.

Methods: This study used a retrospective cross-sectional design. Read More

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December 2018

Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs.

FASEB J 2018 Dec 6:fj201800981R. Epub 2018 Dec 6.

Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

As mechanisms controlling redox homeostasis become impaired with aging, exaggerated oxidant stress may cause disproportional oxidation of cell membranes and circulating phospholipids (PLs), leading to the formation of truncated oxidized PL products (Tr-OxPLs), which exhibit deleterious effects. This study investigated the role of elevated Tr-OxPLs as a factor exacerbating inflammation and lung barrier dysfunction in an animal model of aging. Mass spectrometry analysis of Tr-OxPL species in young (2-4 mo) and aging (18-24 mo) mice revealed elevated basal levels of several products [1-palmitoyl-2-(5-oxovaleroyl)- sn-glycero-phosphocholine (POVPC), 1-palmitoyl-2-glutaroyl- sn-glycero-phosphocholine, lysophosphocholine, 1-palmitoyl-2-(9-oxo-nonanoyl)- sn-glycero-3-phosphocholine, 1-palmitoyl-2-azelaoyl- sn-glycero-3-phosphocholine, O-1-O-palmitoyl-2-O-(5,8-dioxo-8-hydroxy-6-octenoyl)-l-glycero-3-phosphocholine, and others] in the aged lungs. Read More

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December 2018
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The nature of decision-making in people living with dementia: a systematic review.

Aging Ment Health 2018 Dec 6:1-11. Epub 2018 Dec 6.

a Research Department of Clinical, Educational and Health Psychology, Faculty of Brain Sciences , University College London , London , UK.

Objective: The objectives of this systematic review were to: 1) understand how people living with dementia are involved in making decisions; 2) explore the different decisional styles and domains of decision-making that people living with dementia experience and 3) identify what influences the level of decisional involvement of people living with dementia.

Methods: A systematic review of literature identified studies from Medline, PsycINFO, HAPI and CINAHL databases. Search terms related to decision-making and dementia. Read More

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December 2018

Social support, social participation, & depression among caregivers and non-caregivers in Canada: a population health perspective.

Aging Ment Health 2018 Dec 6:1-9. Epub 2018 Dec 6.

b Faculty of Health Sciences , Western University , London , Canada.

Objectives: The study used data from the Canadian Longitudinal Study on Aging to investigate the relationships among social support (measured as affectionate support, emotional/informational support, positive social interaction, tangible support), social participation and depression in caregivers and non-caregivers.

Method: Hierarchical multiple regression was used to investigate relationships among social support, social participation, and depression. Analyses of variance were used to examine differences in the means of social support, social participation, and depression between the two participant groups. Read More

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December 2018

Hemodynamic Responses to an Exercise Stress Test in Parkinson's Disease Patients without Orthostatic Hypotension.

Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.

University of Miami, Kinesiology and Sport Sciences, Coral Gable, Florida, United States ;

The presence of postganglionic sympathetic denervation is well established in Parkinson's disease (PD). Denervation at cardiac and blood vessel sites may lead to abnormal cardiovascular and hemodynamic responses to exercise. The aim of the present investigation was to examine how heart rate (HR) and hemodynamics are affected by an exercise test in PD patients without orthostatic hypotension. Read More

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December 2018

Predicting Progression to Mild Cognitive Impairment.

Ann Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Despite much attention to the use of biomarkers for predicting Alzheimer's disease, little information is available at the individual level. We used the population-based Mayo Clinic Study of Aging to estimate absolute risk of cognitive impairment by biomarker group. Risk increased with age and any biomarker abnormality. Read More

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December 2018
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Reproductive homeostasis and senescence in Drosophila melanogaster.

J Gerontol A Biol Sci Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Dept. of Ecology, Evolution, & Behavior University of Minnesota - Twin Cities St. Paul, MN.

The homeostatic properties of reproduction in aging female Drosophila melanogaster are investigated. Classic studies based on cohort analysis suggest that homeostatic capacity declines gradually as daily oviposition rates decline in aging flies. Analysis at the level of individuals gives a very different picture: reproductive homeostasis remains relatively constant for most of adult life until a critical point when oviposition either ceases entirely or continues in dysregulated fashion. Read More

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December 2018

Longitudinal Associations of Sensory and Cognitive Functioning: A Structural Equation Modelling approach.

J Gerontol B Psychol Sci Soc Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry, Universidad Autónoma de Madrid, Spain.

Objectives: although visual and hearing impairments have been found to be associated with cognitive decline in the old age, the mechanism underlying this relationship remains unclear. This study aims at assessing the predictive role of visual and hearing difficulties on subsequent cognitive functioning.

Method: 3,508 individuals aged 60 and over from the cohort of the first (2002) and fifth waves (2010) of the English Longitudinal Study of Ageing (ELSA). Read More

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December 2018
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Association of Audiometric Age-Related Hearing Loss With Depressive Symptoms Among Hispanic Individuals.

JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry, New York State Psychiatric Institute, Vagelos College of Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical Center, Columbia University, New York.

Importance: Age-related hearing loss is highly prevalent and has recently been associated with numerous morbid conditions of aging. Late-life depression is also prevalent and can be resistant to available treatments. Preliminary studies examining the association between hearing loss and late-life depression have been limited by subjective hearing measures, small sample sizes, and primarily white populations. Read More

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December 2018
6 Reads

Eye and Vision Health for Tomorrow: From Recommendations to Coordinated Action.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Indiana University School of Optometry, Bloomington.

In 2016, the report Making Eye Health a Population Health Imperative: Vision for Tomorrow was published by the National Academies of Sciences, Engineering, and Medicine. Conference presentations and key stakeholder discussions have continued the dialogue initiated by this report. In 2018, a stakeholder meeting assessed the feasibility of establishing a backbone organization, a national center that can provide technical and resource assistance regarding eye and vision health. Read More

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December 2018
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p53-Family Proteins in Odontogenic Cysts: An Immunohistochemical Study.

Appl Immunohistochem Mol Morphol 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Specialistic and Dental Sciences.

The present study investigated the immunohistochemical expression of p53, p63, and p73 in different types of odontogenic cysts (OC), a group of common intraosseous jaw lesions, to provide a better understanding of p53-family functions in odontogenic lesions. We carried out immunohistochemical analysis to evaluate the expression of p53, p63, and p73 in 60 samples of OC, including dentigerous cysts, radicular cysts, orthokeratinized OC, and odontogenic keratocysts (OKC). The epithelial expression of p53-family members was evaluated both in the basal-parabasal and in the superficial layers, measuring the percentage of positive cells and the value of expression intensity. Read More

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December 2018

A secretory pathway kinase regulates sarcoplasmic reticulum Ca homeostasis and protects against heart failure.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Pharmacology, University of California, San Diego, La Jolla, United States.

Ca signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved in Ca signaling have been shown to be phosphorylated, the biochemical and physiological roles of protein phosphorylation within the lumen of the SR remain essentially uncharacterized. Our laboratory recently identified an atypical protein kinase, Fam20C, which is uniquely localized to the secretory pathway lumen. Read More

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December 2018
2 Reads

Does lifestyle matter? Individual lifestyle factors and their additive effects associated with cognitive function in older men and women.

Aging Ment Health 2018 Dec 6:1-8. Epub 2018 Dec 6.

a Department of Social Work and Social Administration , The University of Hong Kong , Hong Kong.

Objectives: This study investigated the association between healthy lifestyle comprised of multiple domains, gender, and cognitive function in older Chinese people in Hong Kong.

Methods: We conducted a cross-sectional analysis with data from 1,831 community-dwellers aged 65 years and above. Participants' basic demographics, comorbidity, and six lifestyle factors: diet; smoking; alcohol drinking; and physical, mental, and social activities were surveyed. Read More

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December 2018

Increased Vulnerability to Atrial Fibrillation Is Associated With Increased Susceptibility to Alternans in Old Sheep.

J Am Heart Assoc 2018 Dec;7(23):e009972

1 The University of Manchester United Kingdom.

Background Atrial fibrillation ( AF ) is common in the elderly, but rare in the young; however, the changes that occur with age that promote AF are not fully understood. Action potential ( AP ) alternans may be involved in the initiation of AF . Using a translationally relevant model, we investigated whether age-associated atrial vulnerability to AF was associated with susceptibility to AP alternans. Read More

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December 2018
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Psychological benefits of attending the theatre associated with positive affect and well-being for subscribers over age 60.

Aging Ment Health 2018 Dec 6:1-8. Epub 2018 Dec 6.

a Dept. of Psychological & Brain Sciences , University of Louisville , Louisville , KY , USA.

Objectives: Although late adulthood may be a time of greater well-being, optimal aging still characterizes a minority of older adults. Understanding how individuals achieve well-being across adulthood is important for intervention and social policy. We focused on how attending live theatre might enhance the well-being of a sample of 53 season ticket holders aged 60 and older. Read More

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December 2018
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The change of volume of the lumbar vertebrae along with aging in asymptomatic population: a preliminary analysis.

Acta Bioeng Biomech 2018 ;20(4):25-30

Department of Orthopedics and Traumatology, W. Dega University Hospital, Poznań, Poland.

Introduction: Previous studies have demonstrated that the length of the lumbar spine is decreasing with age. Despite considerable research based on sagittal measurements, little is known about the changes in the volume of vertebrae. The objective of this study was to evaluate the changes in the volume of either column of the spine with age. Read More

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January 2018
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The effect of aging and gender on plantar pressure distribution during the gait in elderly.

Acta Bioeng Biomech 2018 ;20(4):139-144

Faculty of Sports Studies, Masaryk University, Brno, Czech Republic.

Purpose: The effect of age on structural foot characteristics as well as on the plantar pressure distribution has been shown previously. However, the number of studies focused also on gender gait differences of elderly is lacking. The purpose of this study was to compare dynamic gait characteristic in younger and older elderly and to investigate the gender differences as the life-long load and footwear choice differ in males and females. Read More

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January 2018

A Rare Diagnosis After the Fall of a 96-Year-Old Woman: Doege-Potter Syndrome.

Curr Aging Sci 2018 Dec 5. Epub 2018 Dec 5.

Acute Geriatrics Unit, Monza (MB). Italy.

Introduction: Doege-Potter syndrome (DPS) is a rare but life-threatening paraneoplastic syndrome, characterized by non-islet cell tumor-induced hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT), which secretes an incompletely processed form of insulin-like growth factor 2 (IGF-2).

Results: A 96-year-old woman was admitted with head trauma due to an accidental fall. During her hospital stay she experienced frequent hypoglycemic episodes. Read More

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December 2018

The impact of the implementation of the Dutch combined Meeting Centres Support Programme for family caregivers of people with dementia in Italy, Poland and UK.

Aging Ment Health 2018 Dec 6:1-11. Epub 2018 Dec 6.

j Department of Psychiatry , VU University Medical Centre , Amsterdam , The Netherlands.

Objectives: The MEETINGDEM research project aimed to implement the combined Dutch Meeting Centre Support Programme (MCSP) for community-dwelling people with dementia and caregivers within Italy, Poland and UK and to assess whether comparable benefits were found in these countries as in the Netherlands.

Method: Nine pilot Meeting Centres (MCs) participated (Italy-5, Poland-2, UK-2). Effectiveness of MCSP was compared to usual care (UC) on caregiver outcomes measuring competence (SSCQ), mental health (GHQ-12), emotional distress (NPI-Q) and loneliness (UCLA) analysed by ANCOVAs in a 6-month pre-test/post-test controlled trial. Read More

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December 2018

A new approach to lower eyelid-cheek junction rejuvenation.

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Beijing Lomeye Cosmetic Surgery Clinic, Beijing, China.

Background: Anti-aging in lower eyelid-cheek junction area has always been the upmost widely sought of cosmetic surgery. Removal of orbital fat from inside or outside, removal of part of the skin or even the orbicularis muscle, superficial pull and deep fill and a series of surgical procedures like these have been or are becoming the mainstream of clinical practice. However, aging involves a variety of tissues and causes, which is a dynamic and continuous process. Read More

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December 2018
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Advanced Paternal Age, Infertility, and Reproductive Risks: A Review of the Literature.

Prenat Diagn 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, Rutgers/Robert Wood Johnson Medical School, New Brunswick, NJ.

Advanced paternal age (APA) is associated with infertility and other reproductive risks. Studies looking at APA and outcomes have used different paternal age cut-offs, which has complicated systematic evaluations of reproductive risk associated with paternal aging. This review of the literature suggests that the impact of paternal aging on adverse reproductive outcomes is small, but significant. Read More

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December 2018

Daily and per-meal animal and plant protein intake in relation to muscle mass in healthy older adults without functional limitations: an enable study.

Aging Clin Exp Res 2018 Dec 5. Epub 2018 Dec 5.

Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, Kobergerstraße 60, 90408, Nuremberg, Germany.

Objective: Animal protein sources are considered to be of higher quality than plant protein sources in terms of stimulating muscle metabolism. Our objective was to investigate whether protein intake from animal and plant sources on a daily and per-meal basis differs between healthy older adults with normal and with low muscle mass.

Methods: In this cross-sectional study including 100 healthy, community-dwelling adults (51 women) aged 75-85 years without functional limitations dietary intake was assessed using 7-day food records. Read More

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December 2018

The Finnish Interprofessional Medication Assessment (FIMA): baseline findings from home care setting.

Aging Clin Exp Res 2018 Dec 5. Epub 2018 Dec 5.

Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Purpose: Medication-related problems and declined functional capacity are closely associated factors among older people. The purpose of this study is to describe the procedure of interprofessional medication assessment in home care context and the baseline characteristics of the study population.

Methods: The FIMA study was a randomized, controlled intervention study comparing general practitioner-led interprofessional medication assessment and usual care. Read More

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December 2018

Mouse models of Alzheimer's disease cause rarefaction of pial collaterals and increased severity of ischemic stroke.

Angiogenesis 2018 Dec 5. Epub 2018 Dec 5.

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 6309 MBRB, Chapel Hill, NC, 27599-7545, USA.

Vascular dysfunction contributes to the progression and severity of Alzheimer's disease (AD). Patients with AD also sustain larger infarctions after ischemic stroke; however, the responsible mechanisms are unknown. Pial collaterals are the primary source of protection in stroke. Read More

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December 2018

Older African Americans and the HIV Care Continuum: A Systematic Review of the Literature, 2003-2018.

AIDS Behav 2018 Dec 5. Epub 2018 Dec 5.

Department of Epidemiology and Biostatistics, University of Maryland, College Park, MD, USA.

Evidence suggests that racial disparities in the HIV care continuum persist in older age groups, particularly among African Americans. The objective of this systematic review was to identify factors that facilitate or hinder older African Americans' engagement in the HIV care continuum. For studies published between 2003 and 2018, we: (1) searched databases using keywords, (2) excluded non-peer-reviewed studies, (3) limited findings to older African Americans and the HIV care continuum, and (4) retrieved and summarized data focused on barriers and facilitators of the HIV care continuum. Read More

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December 2018

Discrepancy Between Equations Estimating Kidney Function in Geriatric Care: A Study of Implications for Drug Prescription.

Drugs Aging 2018 Dec 6. Epub 2018 Dec 6.

CHU Bordeaux, Département de Gérontologie Clinique, Avenue du Haut-Lévêque, F-33604, Pessac, France.

Background: In older patients, the agreement is low between creatinine clearance estimated with the Cockcroft-Gault equation (eCrCl) and glomerular filtration rate estimated with the Chronic Kidney Disease Epidemiology Collaboration equation (eGFR). The implications of these discrepancies for drug prescription have so far been assessed only for a few selected molecules.

Objective: The aim of this study was to investigate the proportion of geriatric patients receiving drugs with a different recommended dose or indication (i. Read More

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December 2018

eQTL of KCNK2 regionally influences the brain sulcal widening: evidence from 15,597 UK Biobank participants with neuroimaging data.

Brain Struct Funct 2018 Dec 5. Epub 2018 Dec 5.

UNATI, Institut Joliot, CEA, Université Paris-Saclay, Neurospin, CEA Saclay, Neurospin Bâtiment 145, 91191, Gif-sur-Yvette Cedex, France.

The grey and white matter volumes are known to reduce with age. This cortical shrinkage is visible on magnetic resonance images and is conveniently identified by the increased volume of cerebrospinal fluid in the sulci between two gyri. Here, we replicated this finding using the UK Biobank dataset and studied the genetic influence on these cortical features of aging. Read More

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December 2018
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Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri.

Biogerontology 2018 Dec 5. Epub 2018 Dec 5.

Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.

Current studies have generated disputes on the age-related change in the concentration of growth differentiation factor 11 (GDF11) and its role in the genesis of rejuvenation conditions. In this study we showed for the first time that both GDF11 gene expression and its protein abundance decreased with age in the fish Nothobranchius guentheri. We also showed that rGDF11 fed was indeed absorbed by the fish. Read More

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December 2018

L-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway.

Biogerontology 2018 Dec 5. Epub 2018 Dec 5.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, China.

Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in adipose tissue SASP and dysfunction. Read More

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December 2018

Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases.

Geroscience 2018 Dec 5. Epub 2018 Dec 5.

Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, 277 McElroy Hall, Stillwater, OK, 74078, USA.

Chronic sympathetic nervous system overactivity is a hallmark of aging and obesity and contributes to the development of cardiovascular diseases including hypertension and heart failure. The cause of this chronic sympathoexcitation in aging and obesity is multifactorial and centrally mediated. In this mini-review, we have provided an overview of the key and emerging central mechanisms contributing to the pathogenesis of sympathoexcitation in obesity and healthy aging, specifically focusing on hypertension. Read More

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December 2018

Migration and cognitive function: a conceptual framework for Global Health Research.

Glob Health Res Policy 2018 22;3:34. Epub 2018 Nov 22.

3New York University Rory Meyers College of Nursing, New York, NY USA.

Background: Migration is a fundamental demographic process that has been observed globally. It is suggested that migration is an issue of global health importance that can have an immediate and lasting impact on an individual's health and well-being. There is now an increasing body of evidence linking migration with cognitive function in older adults. Read More

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November 2018

Astrocyte HIF-2α supports learning in a passive avoidance paradigm under hypoxic stress.

Hypoxia (Auckl) 2018 8;6:35-56. Epub 2018 Nov 8.

Department of Anesthesiology and Pain Management, University of Texas Southwestern, Dallas, TX, USA,

Background: The brain is extensively vascularized, useŝ20% of the body's oxygen, and is highly sensitive to changes in oxygen. While synaptic plasticity and memory are impaired in healthy individuals by exposure to mild hypoxia, aged individuals appear to be even more sensitive. Aging is associated with progressive failure in pulmonary and cardiovascular systems, exposing the aged to both chronic and superimposed acute hypoxia. Read More

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November 2018
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Stroke Patients' Acceptance of a Smart Garment for Supporting Upper Extremity Rehabilitation.

IEEE J Transl Eng Health Med 2018 18;6:2101009. Epub 2018 Oct 18.

Industrial Design DepartmentEindhoven University of Technology5612AZEindhovenThe Netherlands.

The objective is to evaluate to which extent that a garment equipped with sensors that can support posture monitoring can be used in upper extremity rehabilitation training of stroke patients. Seventeen stroke survivors (mean age: 55 years old, SD =13.5) were recruited in three hospitals in Shanghai. Read More

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October 2018

Maternal age effects on fecundity and offspring egg-to-adult viability are not affected by mitochondrial haplotype.

Ecol Evol 2018 Nov 18;8(22):10722-10732. Epub 2018 Oct 18.

School of Biological Sciences Monash University Clayton Victoria Australia.

While numerous studies have demonstrated that mitochondrial genetic variation can shape organismal phenotype, the level of contribution the mitochondrial genotype makes to life-history phenotype across the life course remains unknown. Furthermore, a clear technical bias has emerged in studies of mitochondrial effects on reproduction, with many studies conducted on males, but few on females. Here, we apply a classic prediction of the evolutionary theory of aging to the mitochondrial genome, predicting the declining force of natural selection with age will have facilitated the accumulation of mtDNA mutations that confer late-life effects on female reproductive performance. Read More

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November 2018

Masters or pawns? Examining injury and chronic disease in male Masters Athletes and chess players compared to population norms from the Canadian Community Health Survey.

Eur Rev Aging Phys Act 2018 30;15:15. Epub 2018 Nov 30.

1School of Kinesiology and Health Science, York University, 116 Norman Bethune College, 4700 Keele St., Toronto, ON M3J 1P3 Canada.

Background: Identifying the optimal type and amount of activity for the maintenance of function in older adults has proved challenging. On the one hand, Masters Athletes have been proposed as the ideal model of successful aging but most of this research has focused on physical functioning. On the other hand, the importance of cognitive engagement has been emphasized, which may be more strongly related to activities such as playing chess. Read More

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November 2018

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota.

Immun Ageing 2018 29;15:32. Epub 2018 Nov 29.

1Cell Biology and Immunology Group, Wageningen University, Wageningen, the Netherlands.

Background: The influence of age on basophils is poorly understood, as well as the effect of aging-associated microbiota on basophils. Therefore, we studied the influence of aging and aging-associated microbiota on basophil frequency and phenotype, and differentiation from basophil precursors.

Results: Basophils became more abundant in bone marrow (BM) and spleens of 19-month-old mice compared with 4-month-old mice. Read More

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November 2018

1-(5-Bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] Inhibits MMP-9 Expression by Regulating NF-κB and MAPKs Signaling Pathways in HT1080 Human Fibrosarcoma Cells.

Evid Based Complement Alternat Med 2018 5;2018:5639486. Epub 2018 Nov 5.

College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China.

Hippocampus is a traditional medicine in China, which can be used for treating tumors, aging, fatigue, thrombosis, inflammation, hypertension, prostatic hyperplasia, and other diseases. 1-(5-Bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] from seahorse (a Bleeler) has been shown to suppress proinflammatory responses. In the present study, SE1 potently inhibited gelatin digestion by MMP-9 induced by phorbol 12-myristate 13-acetate (PMA) and migration of human fibrosarcoma HT1080 cells in dose-dependent manner. Read More

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November 2018

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death.

Front Immunol 2018 14;9:2647. Epub 2018 Nov 14.

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Shanghai, China.

Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary control on muscles. The etiologies vary among different subtypes of ALS, and no effective management or medication could be provided to the patients, with the underlying mechanisms incompletely understood yet. Mutations in human (Optineurin), particularly E478G, have been found in many ALS patients. Read More

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November 2018