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    1935 results match your criteria Aging Clinical and Experimental Research[Journal]

    1 OF 39

    Six-month observational follow-up on activities of daily living in people with dementia living in nursing homes after a 6-month group based on either exercise or social activities.
    Aging Clin Exp Res 2018 Jun 7. Epub 2018 Jun 7.
    Gérontopôle de Toulouse, Institut du Vieillissement, Bâtiment B, Centre Hospitalo-Universitaire de Toulouse, 37 Allée Jules Guesdes, 31000, Toulouse, France.
    Background: Studies have demonstrated changes in activities of daily living after an exercise intervention in people with dementia (PWD) living in nursing homes (NH). However, some discrepancies are shown during follow-up.

    Aims: Our objective was to measure activities of daily living (ADL) performance during a 6-month observational follow-up after a 6-month exercise or social activity intervention in PWD living in NH. Read More

    External validation of the PALIAR index for patients with advanced, nononcologic chronic diseases.
    Aging Clin Exp Res 2018 Jun 6. Epub 2018 Jun 6.
    Research Group on Comorbidity and Polyphatology in Aragón, Aragón Health Sciences Institute, Avda San Juan Bosco 13 (CIBA), 50009, Zaragoza, Spain.
    Objective: To externally validate the PALIAR index for patients with advanced, nononcologic chronic diseases.

    Methods: We performed a prospective, multicenter cohort study that included patients with advanced, nononcologic chronic diseases hospitalized in internal medicine departments and treated consecutively by the researchers between July 1st and December 31st, 2014. Data were collected from each patient on age, sex, advanced disease, Charlson index, comorbidities, Barthel index, terminal illness symptoms, need for caregiver, hospitalization in the past 3 and 12 months and number of drugs. Read More

    Are changes in pain, cognitive appraisals and coping strategies associated with changes in physical functioning in older adults with joint pain and chronic diseases?
    Aging Clin Exp Res 2018 Jun 6. Epub 2018 Jun 6.
    Department of Rehabilitation Medicine, VU University Medical Center Amsterdam, Amsterdam, Netherlands.
    Background: As the population ages, the number of people with chronic diseases increases. Frequently, older people suffer from joint pain together with other chronic diseases, which can lead to decreased physical functioning.

    Aims: To investigate the associations of the changes in cognitive appraisals, coping strategies and pain with the change in physical functioning in older people, who have chronic pain and chronic diseases. Read More

    The association of indwelling urinary catheter with delirium in hospitalized patients and nursing home residents: an explorative analysis from the "Delirium Day 2015".
    Aging Clin Exp Res 2018 Jun 1. Epub 2018 Jun 1.
    School of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 1, 20126, Milano, Italy.
    Backround: Use of indwelling urinary catheter (IUC) in older adults has negative consequences, including delirium.

    Aim: This analysis, from the "Delirium Day 2015", a nationwide multicenter prevalence study, aim to evaluate the association of IUC with delirium in hospitalized and Nursing Homes (NHs) patients.

    Methods: Patients underwent a comprehensive geriatric assessment, including the presence of IUC; inclusion criteria were age > 65 years, being Italian speaker and providing informed consent; exclusion criteria were coma, aphasia, end-of-life status. Read More

    Predisposing factors to heart failure in diabetic nephropathy: a look at the sympathetic nervous system hyperactivity.
    Aging Clin Exp Res 2018 Jun 1. Epub 2018 Jun 1.
    Division of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.
    Diabetes mellitus (DM) and heart failure (HF) are frequent comorbidities among elderly patients. HF, a leading cause of mortality and morbidity worldwide, is characterized by sympathetic nervous system hyperactivity. The prevalence of diabetes mellitus (DM) is rapidly growing and the risk of developing HF is higher among DM patients. Read More

    Physical performance across the thyroid function values within the normal range in adult and older persons.
    Aging Clin Exp Res 2018 May 29. Epub 2018 May 29.
    National Institute on Aging, Baltimore, MD, USA.
    Background: Thyroid hormone variation may be correlated with adverse health outcomes, even within the normal reference range in euthyroid individuals.

    Aims: To determine the association between plasma thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels and physical performance score in middle age and older adults who had levels of all three hormones in the normal range.

    Methods: In this community-based, cross-sectional study, euthyroid participants of the Invecchiare in Chianti study, aged 23-102 years (N = 1060), were considered. Read More

    Operative and prognostic parameters associated with elective versus emergency surgery in a retrospective cohort of elderly patients.
    Aging Clin Exp Res 2018 May 29. Epub 2018 May 29.
    Department of Anesthesiology, Van Yuzuncu Yil University Medical Faculty, Van, Turkey.
    Aim: To evaluate operative and prognostic parameters associated with elective versus emergency surgery in a retrospective cohort of elderly patients.

    Methods: A total of 533 geriatric patients (aged ≥ 65 years, median age: 73.0 years, 50. Read More

    Assessment and clinical implications of cognitive impairment in acutely ill geriatric patients using a revised simplified short-term memory recall test (STMT-R).
    Aging Clin Exp Res 2018 May 24. Epub 2018 May 24.
    School of Medicine, Kurume University, Kurume, Japan.
    Background: Cognitive dysfunction due to delirium or dementia is a common finding in acutely ill geriatric patients, but often remains undetected. A brief and sensitive clinical identification method could prevent errors or complications while evaluating the mental status of elderly patients.

    Aims: To evaluate the usefulness and clinical implications of the revised simplified short-term memory recall test (STMT-R) in geriatric patients admitted in the emergency department; with age, gender, dementia history, serum albumin, underlying diseases and clinical outcome used as comparative factors. Read More

    Two years of maintenance hemodialysis has a pronounced effect on arterial stiffness progression.
    Aging Clin Exp Res 2018 May 19. Epub 2018 May 19.
    Clinic of Gastroenterology, Nephrourology and Abdominal Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
    Background: The change of aortic stiffness, but not the particular baseline value, plays a crucial role in estimating the patient risk with end-stage renal disease. Therefore, we aimed to analyze the evolution of central and peripheral arterial stiffness in hemodialysis population without previous cardiovascular events during a 2-year follow-up.

    Methods: 60 hemodialysis patients (mean age 57. Read More

    Cardiac and gait rhythms in healthy younger and older adults during treadmill walking tasks.
    Aging Clin Exp Res 2018 May 17. Epub 2018 May 17.
    University of North Carolina at Greensboro, Greensboro, NC, USA.
    Background: Aging and pathology result in changes in the dynamics of several physiological subsystems. Often, these changes are concurrent, altering the dynamics between subsystems. Cardiac and gait rhythms are one example in which patterns change during physical activity. Read More

    Comparison of procalcitonin, a potentially new inflammatory biomarker of frailty, to interleukin-6 and C-reactive protein among older Chinese hospitalized patients.
    Aging Clin Exp Res 2018 May 17. Epub 2018 May 17.
    Collaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Chengdu, China.
    Aim: Procalcitonin (PCT) has predictive value for patients with infectious diseases, but has not been studied in frailty. The purpose of this study was to compare PCT to two other inflammatory biomarkers [interleukin-6 (IL-6)] and C-reactive protein (CRP) in their association with frailty among older hospitalized patients.

    Methods: Retrospective study of inpatients (June-December, 2016), who had all three biomarkers measured within 24 h of admission. Read More

    Effects of resistance training, detraining, and retraining on strength and functional capacity in elderly.
    Aging Clin Exp Res 2018 May 17. Epub 2018 May 17.
    Laboratório de Biomecânica, Centro de Desportos, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
    Background: The interruption of training (detraining) results in loss of the gains acquired. Partial retention could occur after detraining, and variation in training stimuli may optimize retraining adaptations.

    Aim: To evaluate the effect of a resistance-retraining program on strength and functional capacity performance after a detraining period. Read More

    Cross-sectional study on hospitalizations related to herpes zoster in an Italian region, 2008-2016.
    Aging Clin Exp Res 2018 May 15. Epub 2018 May 15.
    Department of Cardiac, Thoracic and Vascular Sciences, Hygiene and Public Health Unit, University of Padua, Via Loredan, 18, 35121, Padua, Italy.
    Introduction: To assess the burden of herpes zoster (HZ) by analyzing HZ-related hospital admissions.

    Methods: We conducted a population-based descriptive cross-sectional study on all hospitalizations for HZ among the resident population admitted to all public and accredited private hospitals in the Veneto Region (north-east Italy) during the years 2008-2016. HZ hospitalizations were identified from the International Classification of Diseases codes in the hospital discharge records. Read More

    Author Correction: Reliability and feasibility of gait initiation centre-of-pressure excursions using a Wii Balance Board in older adults at risk of falling.
    Aging Clin Exp Res 2018 May 12. Epub 2018 May 12.
    Physiotherapy Department, 3rd Floor Lambeth Wing, St Thomas' Hospital, Westminster Bridge Road, Guy's & St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
    In the original publication, the article title was incorrectly published as 'Reliability and feasibility of gait initiation centre-of-pressure excursions using a Wii® Balance Board in older adults at risk of failing'. The correct title should read as 'Reliability and feasibility of gait initiation centre-of-pressure excursions using a Wii® Balance Board in older adults at risk of falling'. Read More

    Temporal characteristics of imagined and actual walking in frail older adults.
    Aging Clin Exp Res 2018 May 9. Epub 2018 May 9.
    Department of Physical Therapy, Faculty of Health Science, Kyoto Tachibana University, 34 Yamada-cho, Oyake, Yamashina-ku, Kyoto, 607-8175, Japan.
    Background: Mental chronometry, commonly used to evaluate motor imagery ability, measures the imagined time required for movements. Previous studies investigating mental chronometry of walking have investigated healthy older adults. However, mental chronometry in frail older adults has not yet been clarified. Read More

    Validation of the Spanish version of the Pittsburgh Fatigability Scale for older adults.
    Aging Clin Exp Res 2018 May 8. Epub 2018 May 8.
    Intermediate Care Hospital, Parc Sanitari Pere Virgili, Av. Esteve Terrada No 30, 08023, Barcelona, Spain.
    Background: The Pittsburgh Fatigability Scale (PFS) is the only validated scale for measuring perceived fatigability in older adults.

    Aims: We validated the PFS Spanish version by assessing convergent validity with respect to several measures of physical performance, physical activity, physical function and disability.

    Methods: A cross-sectional validation study of 79 community-dwelling older adults aged 70 and older from Barcelona, Spain was included. Read More

    Prognostic value of cardiac troponin I assay in hospitalized elderly patients.
    Aging Clin Exp Res 2018 May 4. Epub 2018 May 4.
    Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani, 2, 35128, Padua, Italy.
    Background: Cardiac troponin I (cTnI) has been poorly studied in elderly inpatients.

    Aim: This study wanted to assess factors influencing the increase in cTnI and its prognostic value in hospitalized elderly patients.

    Methods: 354 elderly (mean age of 84. Read More

    Study of diagnostic accuracy of Fagan's two-step nomogram in increasing the value of predictive tools for prostate cancer: application of specific spatial distribution of positive/negative bioptic cores to predict extracapsular extension.
    Aging Clin Exp Res 2018 May 2. Epub 2018 May 2.
    Department of Surgery, Oncology and Gastroenterology - Urology, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
    Background: Prostate cancer (PC) represents the second most frequent cancer in the male population worldwide. It is mandatory to have a very accurate staging to choice the best possible treatment.

    Aims: To test the possibility of improving the performance of Partin's tables in predicting the pathological staging of PC by introducing bioptic parameters through an innovative statistic tool (Fagan's two-step nomogram). Read More

    Herpes zoster in frail elderly patients: prevalence, impact, management, and preventive strategies.
    Aging Clin Exp Res 2018 May 2. Epub 2018 May 2.
    Department of Medical Sciences, University of Ferrara, via Fossato di Mortara 64, 44121, Ferrara, Italy.
    Population aging is a worldwide phenomenon with significant and manifold impacts on society. Advanced age correlates with the onset of frailty. In this vulnerable state, the immune response is weakened and a higher susceptibility to infectious diseases is observed. Read More

    The prevalence and health burden of malnutrition in Belgian older people in the community or residing in nursing homes: results of the NutriAction II study.
    Aging Clin Exp Res 2018 Apr 30. Epub 2018 Apr 30.
    Nutrition Support Team, Department of Gastroenterology, Hôpital Erasme, ULB, Brussels, Belgium.
    Introduction: In 2008, the NutriAction study showed that (risk of) malnutrition was highly prevalent (57%) among Belgian older people living in the community or in a nursing home. In 2013, this study was repeated to re-evaluate the occurrence of malnutrition, as well as mobility problems and dependence in activities of daily living (ADL).

    Methods: Health care professionals (HCPs) associated with homecare organizations and nursing homes across Belgium were invited to screen their patients and complete an online questionnaire. Read More

    Self-monitoring to increase physical activity in patients with cardiovascular disease: a systematic review and meta-analysis.
    Aging Clin Exp Res 2018 Apr 30. Epub 2018 Apr 30.
    Department of Public Health, Graduate School of Health Science, Kobe University, 7-10-2 Tomogaoka, Suma-ku, Kobe, 654-0142, Japan.
    Background And Aims: It is important to encourage physical activity in patients with cardiovascular disease (CVD), and self-monitoring is considered to contribute to increased physical activity. However, the effects of self-monitoring on CVD patients remain to be established. In this study, we examined the influence of self-monitoring on physical activity of patients with CVD via a systematic review and meta-analysis. Read More

    When and where in aging: the role of music on source monitoring.
    Aging Clin Exp Res 2018 Jun 30;30(6):669-676. Epub 2018 Apr 30.
    Department of Psychological Sciences, School of Medicine and Health Sciences, University of Chieti, Chieti, Italy.
    Difficulties in source monitoring (SM) tasks observed in healthy older adults may be linked to associative memory deficits since SM requires individuals to correctly bind and later remember these bound features to discriminate the origin of a memory. Therefore, focusing attention on discriminating factors that may attenuate older adults' difficulties in attributing contextual information to memories is necessary. We investigated the effect of affective information on source monitoring in younger and older adults by manipulating the type of affective information (pictures and music) and assessing the ability to remember spatial and temporal source details for affective pictures encoded while listening to classical music. Read More

    A physical exercise program using music-supported video-based training in older adults in nursing homes suffering from dementia: a feasibility study.
    Aging Clin Exp Res 2018 Apr 28. Epub 2018 Apr 28.
    Faculty of Medicine and Life Sciences, REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Hasselt University, Agoralaan Building A, 3590, Diepenbeek, Belgium.
    Background: Motivation towards an exercise program is higher in a small group setting in comparison to individual therapy. Due to attentional problems, group exercises are difficult for people with Alzheimer disease (AD). This study evaluates the feasibility of a music-supported video-based group exercise program in older adults suffering from AD. Read More

    Neurologic manifestations of elderly patients with cancer.
    Aging Clin Exp Res 2018 Apr 27. Epub 2018 Apr 27.
    Geriatric Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, 14080, Ciudad de México, Mexico.
    Background: The incidence of cancer is an age-related phenomenon; therefore, the interest on clinical manifestations, diagnostic approach and treatment strategies for older patients diagnosed with cancer has increased lately. Neurologic symptoms are one of the main reasons for consultation and a common cause of decreased quality of life among cancer patients.

    Aims: To identify the neurologic manifestations of patients ≥ 65 years of age diagnosed with cancer and compare them to those presented by a younger population. Read More

    Assessing sarcopenia with vastus lateralis muscle ultrasound: an operative protocol.
    Aging Clin Exp Res 2018 Apr 26. Epub 2018 Apr 26.
    Department of Medicine and Surgery, University of Parma, Via Antonio Gramsci 14, 43126, Parma, Italy.
    Background: Muscle ultrasound (MUS) has so far not been implemented for sarcopenia assessment in clinical geriatric practice due to allegedly low reproducibility of results in the absence of standardization of procedures. However, rigorous and standardized application of this technique yields highly reproducible results. Its application, especially if integrated with clinical evaluation and comprehensive geriatric assessment, proofs very useful for rapidly obtaining information on muscle mass and architecture. Read More

    Improved outcomes following implementation of a multidisciplinary care pathway for elderly hip fractures.
    Aging Clin Exp Res 2018 Apr 23. Epub 2018 Apr 23.
    Department of Orthopedics, Nassau University Medical Center, East Meadow, New York, USA.
    Background: Hip fractures in patients 65 years and older are associated with significant morbidity and mortality. With the steady increase in the elderly population, we implemented an evidence-based clinical practice guideline for the management of hip fractures to optimize patient care and surgical outcomes.

    Aims: To evaluate the effects of a multidisciplinary hip fracture care pathway on patient outcomes in the care of elderly patients. Read More

    Effects of Psidium guajava Linn. leaf extract in Japanese subjects with knee pain: a randomized, double-blind, placebo-controlled, parallel pilot study.
    Aging Clin Exp Res 2018 Apr 23. Epub 2018 Apr 23.
    Biological Science Research Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan.
    The extract of Psidium guajava Linn. (guava) leaf was recently revealed to suppress the advance of osteoarthritis (OA) in rat anterior cruciate ligament-transection models. To investigate the efficacy of guava leaf extract in improving knee pain, which is a common symptom of OA, we conducted a double-blind parallel pilot clinical study in Japanese subjects with knee pain. Read More

    The influence of participation on mortality in very old age among community-living people in Sweden.
    Aging Clin Exp Res 2018 Apr 20. Epub 2018 Apr 20.
    Department of Health Sciences, Lund University, Box 157, 221 00, Lund, Sweden.
    Background: Participation in everyday life and society is generally seen as essential for health-related outcomes and acknowledged to affect older people's well-being.

    Aims: To investigate if aspects of performance- and togetherness-related participation influence on mortality among very old single living people in Sweden.

    Methods: ENABLE-AGE Survey Study data involving single-living participants in Sweden (N = 314, aged 81-91 years), followed over 10 years were used. Read More

    Gender differences in home-based cardiac rehabilitation of post-percutaneous coronary intervention patients.
    Aging Clin Exp Res 2018 Apr 20. Epub 2018 Apr 20.
    Sports and Health Care Major, College of Humanities and Arts, Korea National University of Transportation, 50 Daehak-ro, Chungju-si, Chungbuk, 380-702, Republic of Korea.
    Cardiac rehabilitation (CR) is a structured program for the prevention of secondary cardiovascular disease (CVD) and related diseases, such as hypertension, diabetes, and obesity. This study aimed to investigate whether there are gender differences after 9 months of home-based cardiac rehabilitation program in post-percutaneous coronary intervention patients. A total of 114 (58. Read More

    Association of cerebrospinal fluid Neurogranin with Alzheimer's disease.
    Aging Clin Exp Res 2018 Apr 17. Epub 2018 Apr 17.
    Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
    Cerebrospinal fluid (CSF) Neurogranin has recently been proposed as a potential biomarker for cognitive decline and brain injury in Alzheimer's disease (AD). To test whether CSF Neurogranin levels are increased in AD and its association with cognitive decline, we examined 99 cognitively normal (CN) subjects, 171 patients with mild cognitive impairment (MCI), and 81 patients with AD in the cross-sectional study from the Alzheimer's Disease Neuroimaging Initiative (ADNI). The results showed that CSF Neurogranin was increased in both AD and MCI compared with controls. Read More

    Reliability and feasibility of gait initiation centre-of-pressure excursions using a Wii Balance Board in older adults at risk of falling.
    Aging Clin Exp Res 2018 Apr 17. Epub 2018 Apr 17.
    Physiotherapy Department, 3rd Floor Lambeth Wing, St Thomas' Hospital, Westminster Bridge Road, Guy's & St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
    Background: Impairments in dynamic balance have a detrimental effect in older adults at risk of falls (OARF). Gait initiation (GI) is a challenging transitional movement. Centre of pressure (COP) excursions using force plates have been used to measure GI performance. Read More

    Supplemented amino acids may enhance the walking recovery of elderly subjects after hip fracture surgery.
    Aging Clin Exp Res 2018 Apr 17. Epub 2018 Apr 17.
    Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia, Viale Taramelli, 14, 27100, Pavia, Italy.
    The purpose of this study was to investigate whether supplemented essential amino acids (EAAs) could enhance rehabilitation therapy (Rehab) for recovery of walking capacity in subjects after hip fracture surgery (HFS). Eighty-three elderly subjects with HFS (20 ± 11 days after acute trauma) were eligible for the study and randomized to receive Rehab only (Rehab; n = 27), Rehab + placebo (RP; n = 28) or Rehab + EAAs (RE 8 g/day; n = 28). The patients' walking capacity (m) was measured by 6-min walking distance (6MWD) at admission and at discharge (median 66 days after admission). Read More

    Falls in Mexican older adults aged 60 years and older.
    Aging Clin Exp Res 2018 Apr 17. Epub 2018 Apr 17.
    Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX, USA.
    Background: Falls are a major cause of disability, morbidity, institutionalization, and mortality in older adults.

    Objectives: The purpose of the study was to examine the risk factors for falls among Mexican older adults aged 60 years and older.

    Methods: This study included 6247 participants and their spouse or partner aged 60 years and older from the Mexican Health and Aging Study, an ongoing longitudinal study (2001-2012) conducted in Mexico. Read More

    Swallowing dysfunction as risk factor for undernutrition in older people admitted to Swedish short-term care: a cross-sectional study.
    Aging Clin Exp Res 2018 Apr 16. Epub 2018 Apr 16.
    Oral and Maxillofacial Radiology, Department of Odontology, Faculty of Medicine, Umeå University, Umeå, Sweden.
    Background: Swallowing dysfunction and risk of undernutrition increase the risk of pneumonia, morbidity, and mortality. Short-term care is an unexplored care context, where many older people stay yearly.

    Aim: This cross-sectional study aimed to describe and analyze the relationship between swallowing dysfunction and risk of undernutrition among older people in short-term care, including potential gender-related differences. Read More

    Related factors of cognitive impairment in community-dwelling older adults in Beijing Longitudinal Study of Aging.
    Aging Clin Exp Res 2018 Apr 9. Epub 2018 Apr 9.
    Beijing Geriatric Healthcare Center, Beijing Institute of Geriatrics, Beijing Institute for Brain Disorders, Key Laboratory on Neurodegenerative Disease of Ministry of Education, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
    Objectives: To investigate the prevalence and related factors of cognitive impairment in community-dwelling older residents in Beijing, China.

    Methods: This is a cross-sectional study. A total of 2017 older individuals aged ≥ 60 years from Beijing Longitudinal Study of Aging were included in this study. Read More

    Elevated post-void residual volume in a geriatric post-hip fracture assessment in women-associated factors and risk of mortality.
    Aging Clin Exp Res 2018 Apr 9. Epub 2018 Apr 9.
    Department of Surgery, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
    Background And Aim: Multiple factors contribute to elevated post-void residual urine volumes (PVR), but they may indicate detrusor underactivity (DU), especially in older women. The aim here was to examine factors associated with and prognostic significance of elevated PVR in a geriatric post-hip fracture assessment in a female population.

    Methods: Consecutive female hip fracture patients (n = 409) aged 65 years and older were included. Read More

    Does 1.5 T mpMRI play a definite role in detection of clinically significant prostate cancer? Findings from a prospective study comparing blind 24-core saturation and targeted biopsies with a novel data remodeling model.
    Aging Clin Exp Res 2018 Apr 3. Epub 2018 Apr 3.
    Department of Surgery, Oncology and Gastroenterology-Urology, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
    Background: Multiparametric-magnetic resonance imaging (mpMRI) can accurately detect high-grade and larger prostate cancers (PC).

    Aims: To evaluate the ability of 1.5 T magnetic field mpMRI-targeted Prostate Biopsies (PBx) in predicting PC in comparison with blind 24-core saturation PBx (sPBx). Read More

    Analysis of symmetry between lower limbs during gait of older women with bilateral knee osteoarthritis.
    Aging Clin Exp Res 2018 Mar 29. Epub 2018 Mar 29.
    Department of Physical Therapy, Postgraduate Program in Rehabilitation Sciences, Universidade Federal de Minas Gerais (UFMG), 6627 Antônio Carlos Avenue, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
    Background: Osteoarthritis (OA) is a common condition in older adults, with high epidemiological, clinical, and economic burden worldwide. In clinical practice, patients with knee OA often walk with abnormal gait patterns because of pain, stiffness and/or mobility dysfunctions. Therefore, assessing the symmetry of the lower limbs might improve the rehabilitation treatment and prescription of walking devices. Read More

    Oligometastatic cancer in elderly patients: the "blitzkrieg" radiotherapy approach
    Aging Clin Exp Res 2018 03 29. Epub 2018 Mar 29.
    Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, Tor Vergata General Hospital, Viale Oxford 81, 00133, Rome, Italy.
    Aims: To retrospectively evaluate the outcome of stereotactic body radiation therapy (SBRT) in the treatment of elderly patients affected by isolated body metastasis from different primitive tumors.

    Methods: 70 patients with isolated body metastasis were treated. Median age at diagnosis was 75 years (IQR 69-80). Read More

    Reliability and validity of the Short Falls Efficacy Scale-International for Japanese older people.
    Aging Clin Exp Res 2018 Mar 29. Epub 2018 Mar 29.
    School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.
    Background: The Short Falls Efficacy Scale-International (Short FES-I) has been confirmed to be a good measure with reliability and validity in a UK sample; however, the reliability and validity of the Short FES-I for Japanese older people have not yet been established.

    Aim: The aim of this study was to determine the reliability and validity of the Short FES-I for Japanese older people.

    Methods: The study participants were 519 older people aged 65 years and over who were living independently in their community. Read More

    Estimation of reduced walking speed using simple measurements of physical and psychophysiological function in community-dwelling elderly people: a cross-sectional and longitudinal study.
    Aging Clin Exp Res 2018 Mar 28. Epub 2018 Mar 28.
    Department of Rehabilitation Science, Nagoya University Graduate School of Medicine, 1-1-20, Daiko-minami, Higashi-ku, Nagoya, 461-8673, Japan.
    Background: Early detection of reduced mobility function is important in elderly people. Usual walking speed is useful to assess mobility function, but is often not feasible in a community setting.

    Aims: This study aimed to explore a simple surrogate indicator of usual walking speed in elderly people. Read More

    Sicilian centenarian offspring are more resistant to immune ageing.
    Aging Clin Exp Res 2018 Mar 28. Epub 2018 Mar 28.
    Department of Pathobiology and Medical Biotechnologies, University of Palermo, Palermo, Italy.
    Background: Immunosenescence constitutes a major indirect cause of morbidity and mortality in the elderly. Previous analysis of immune signatures in a cohort of centenarian offspring showed an intermediate immunophenotype between age-matched and younger controls.

    Aims: To confirm and extend the previous studies performing further phenotypical analysis in centenarian offspring and controls. Read More

    Waist circumference is a better predictor of risk for frailty than BMI in the community-dwelling elderly in Beijing.
    Aging Clin Exp Res 2018 Mar 27. Epub 2018 Mar 27.
    Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Xicheng District, Beijing, 100053, China.
    Aim: Obesity is found to be associated with frailty. Body mass index (BMI) and waist circumference (WC) are the commonly used measures for obesity, the former is more closely related to general obesity and body weight; the latter can more accurately reflect abdominal obesity and is more closely associated with metabolic disorders. In this study, we intend to study the relationship between frailty, BMI and WC among older people. Read More

    The application of the palliative prognostic index in predicting the life expectancy of patients in palliative care: a systematic review and meta-analysis.
    Aging Clin Exp Res 2018 Mar 23. Epub 2018 Mar 23.
    The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, No. 37 Guoxuexiang, Chengdu, 610041, China.
    Background: The palliative prognostic index (PPI) is a commonly used tool to predict the life expectancy in palliative care patients. However, there is no universal cutoff, and the accuracy of different cutoffs varies. Therefore, we conducted this meta-analysis to explore the validity and accuracy of different PPI scores for different survival time in palliative care setting. Read More

    Arterial stiffness and left ventricular performance in elderly patients with persistent atrial fibrillation.
    Aging Clin Exp Res 2018 Mar 22. Epub 2018 Mar 22.
    Geriatric Intensive Care Unit, Department of Experimental and Clinical Medicine, University of Florence and AOU Careggi, Viale Pieraccini 6, 50139, Florence, Italy.
    Background: The prevalence of atrial fibrillation (AF) and arterial stiffness (AS) increases with age.

    Aims: To evaluate if AS is correlated to longitudinal strain (LS), a marker of left ventricular (LV) function, in elderly AF patients with preserved ejection fraction (EF) undergoing external cardioversion.

    Methods: AS was measured using the cardio-ankle vascular index (CAVI), LS was calculated from echocardiographic data of three consecutive cardiac cycles. Read More

    Twenty-year trends in cardiovascular risk among men and women in the United States.
    Aging Clin Exp Res 2018 Mar 22. Epub 2018 Mar 22.
    Andrus Gerontology Center, University of Southern California, Los Angeles, CA, 90089-0191, USA.
    Background: Relative to men, women have experienced slower improvement in mortality in the US in recent decades.

    Aims: We investigated 20-year trends in cardiovascular risk for men and women age 40 and over in the US to determine whether there was differential change in risk for men and women.

    Methods: Using the National Health and Nutrition Examination Survey (NHANES), we estimated total cardiovascular risk, the prevalence of individual risk factors, and potential factors contributing to change in risk. Read More

    Longitudinal comparison of low- and high-velocity resistance training in relation to body composition and functional fitness of older adults.
    Aging Clin Exp Res 2018 Mar 22. Epub 2018 Mar 22.
    University of Oklahoma Medical Center, Oklahoma City, OK, USA.
    Background: Functional mobility disability affects more than one in five adults over 70 years and increases to 80% by 90 years. While negative changes in mobility are multifactorial, deleterious body composition changes contribute significantly. Resistance training alters the negative trajectory of physical function as well as increases lean mass among older adults. Read More

    Sarcopenia and hospital-related outcomes in the old people: a systematic review and meta-analysis.
    Aging Clin Exp Res 2018 Mar 16. Epub 2018 Mar 16.
    The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
    Aim: This systematic review was conducted to explore the associations between sarcopenia, hospitalization and length of stay in the old people.

    Methods: Pubmed, Embase, Medline and Cochrane Central Register of Controlled Trails from January 2009 to October 2017 were searched in this review. We included prospective studies, which had the clear definition of sarcopenia and reported the hospitalization or length of stay as one of outcomes. Read More

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