3,916 results match your criteria Aging Clinical And Experimental Research[Journal]


Improving the mental and physical health of older community-dwellers with a museum participatory art-based activity: results of a multicentre randomized controlled trial.

Aging Clin Exp Res 2022 May 17. Epub 2022 May 17.

Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada.

Background: The aim of this randomized controlled trial (RCT) was to examine the mental and physical effects of a participatory art-based activity carried out at museums in older community-dwellers.

Methods: Based on a bicentre (the Montreal Museum of Fine Arts (MMFA), Montreal, Quebec, Canada; the Fuji Museum, Tokyo, Japan) single-blind RCT in two parallel groups (intervention group versus control group), 228 community-dwelling older adults (mean age 71.1 ± 5. Read More

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The prevalence of undernutrition and associated factors in older obese patients.

Aging Clin Exp Res 2022 May 16. Epub 2022 May 16.

Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK.

Background: Both obesity and malnutrition are common health problems in older adults.

Aim: The aim of our study is to investigate the prevalence of undernutrition and related factors in older obese patients.

Methods: 1911 older outpatients who underwent comprehensive geriatric assessment were included in this cross-sectional study. Read More

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What is the impact of perioperative cerebral oxygen desaturation on postoperative delirium in old population: a systemic review and meta-analysis.

Aging Clin Exp Res 2022 May 16. Epub 2022 May 16.

Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.

Background: Perioperative cerebral oxygen saturation (ScO) has been reported to associate with postoperative delirium (POD) which is a common postoperative complication, however, the results were inconclusive. Therefore, we aimed to conduct an up-to-date review and meta-analyze the relationship between perioperative ScO and POD.

Methods: We systematically searched PubMed, Embase and Web of science through January 13, 2022. Read More

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Influence of atrial fibrillation subtypes on anticoagulant therapy in a high-risk older population: the FAI project.

Aging Clin Exp Res 2022 May 11. Epub 2022 May 11.

Institute of Neuroscience, Italian National Research Council, Via Madonna del Piano, 10 - 50019 Sesto Fiorentino, Florence, Italy.

Background And Aim: Benefits of oral anticoagulants (OAC) in atrial fibrillation (AF) patients with moderate-to-high risk of stroke are independent of AF pattern. We evaluated whether AF clinical subtype influenced OAC use in a representative sample of the Italian older population.

Methods: A cross-sectional examination of all subjects aged 65 + years from three general practices in northern, central, and southern Italy started in 2016. Read More

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Exploring the factors that influence equitable access to and social participation in dementia care programs by foreign-born population living in Toronto and Durham region.

Aging Clin Exp Res 2022 May 9. Epub 2022 May 9.

Research Project Assistant, Faculty of Health Sciences, Ontario Tech University, Oshawa, Canada.

This paper reports the findings of a qualitative study conducted in Ontario, Canada with the purpose of identifying the barriers and facilitating factors of access to dementia care by foreign-born individuals, including immigrants and refugees. Interview data revealed seven overarching themes related to access and participation in dementia care programs by migrants, including structural, process, and outcome barriers. Our study findings suggest that incorporating culturally inclusive activity components in recreational dementia care programs will promote program participation by individuals from ethno-cultural backgrounds. Read More

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The association between healthy aging index and trajectories of disability: a population-based cohort study.

Aging Clin Exp Res 2022 May 6. Epub 2022 May 6.

School of Nursing and School of Public Health, Yangzhou University, No. 136 Jiangyang Road, Yangzhou, Jiangsu, China.

Background: Healthy aging index (HAI) could predict adverse health consequences including mortality and disability independent of age and comorbidity. We investigated the role of HAI on trajectories of disability throughout later life based on a nationally representative sample.

Methods: We examined 1733 participants aged over 60 years from the China Health and Retirement Longitudinal Study (CHARLS) followed for 7 years/4 waves repeatedly. Read More

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The cross-sectional association of frailty with chronic past and current use of benzodiazepine drugs.

Aging Clin Exp Res 2022 May 6. Epub 2022 May 6.

Miami VA Healthcare System Geriatric Research, Education and Clinical Center (GRECC), Veterans Successful Aging for Frail Elders (VSAFE), Bruce W. Carter Miami VAMC, GRECC (11GRC), 1201 NW 16th Street, Miami, FL, 33125, USA.

Background: Frailty, a clinical syndrome characterized by vulnerability to stressors resulting from multisystemic loss of physiological reserve. The use of benzodiazepines in older adults has been associated with confusion, sedation, and cognitive impairment, which in turn may lead to frailty.

Aims: The purpose of this study was to determine the cross-sectional association between frailty and chronic past or current use of benzodiazepine drugs among older US Veterans. Read More

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Reply to the Letter: "Prognosis of dementia patients with hip fracture surgery".

Aging Clin Exp Res 2022 May 3. Epub 2022 May 3.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.

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The association between visual trajectories and cognitive impairment: insights from the Taiwan Longitudinal Study on Aging.

Aging Clin Exp Res 2022 Apr 29. Epub 2022 Apr 29.

Department of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.

Background: Visual impairment (VI) was associated with cognitive impairment. However, different visual trajectories might contribute to different risks of cognitive decline in the elderly.

Aims: This study aimed to evaluate the association between visual trajectories and cognitive impairment. Read More

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Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease.

Aging Clin Exp Res 2022 Apr 26. Epub 2022 Apr 26.

Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China.

This study explored the potential relationship between levels of high-sensitivity C-reactive protein (hs-CRP) in plasma and freezing of gait (FOG) in Parkinson's disease (PD) in China. A total of 72 healthy subjects, 62 PD patients with FOG, and 83 PD patients without FOG from our center were enrolled in this prospective study. Patients with FOG showed significantly higher hs-CRP levels than controls, but patients without FOG did not. Read More

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Resting respiration rate predicts all-cause mortality in older outpatients.

Aging Clin Exp Res 2022 Apr 26. Epub 2022 Apr 26.

Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Although respiratory rate has been a sensitive predictor for prognosis in acute settings, resting respiratory rate (RRR) is undervalued in chronic care. The clinical significance of RRR among older people is not well documented.

Aim: We investigated the association between RRR and all-cause mortality among older outpatients. Read More

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Prior psychosocial profile and perceived impact of the COVID-19 pandemic: insights from the Baltimore Longitudinal Study of Aging.

Aging Clin Exp Res 2022 Apr 26. Epub 2022 Apr 26.

Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.

Stress, social isolation, and changes in health behaviors during the COVID-19 pandemic period may have a lasting influence on health. Here, the correlation between current or prior demographic, social and health related characteristics, including psychosocial factors with perceived impact of the COVID-19 pandemic assessed by questionnaire during the early pandemic period is evaluated among 770 participants of the Baltimore Longitudinal Study of Aging. In multinomial logistic regression models participants with higher pre-pandemic personal mastery, a construct related to self-efficacy, were more likely to report "both positive and negative" impact of the pandemic than a solely "negative" impact (OR: 2. Read More

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Applicability of the interventions recommended for patients at risk or with delirium in medical and post-acute settings: a systematic review and a Nominal Group Technique study.

Aging Clin Exp Res 2022 Apr 22. Epub 2022 Apr 22.

Department of Medical Science, University of Udine, Udine, Italy.

Background: Delirium is a common condition during hospitalisation that should be prevented and treated. Several recommendations have been established to date, whereas few studies have investigated their applicability in daily practice for medical and post-acute settings.

Aim: The aim of this research exercise was to emerge the applicability of the interventions recommended by studies in the daily care of patients at risk or with delirium cared in medical and post-acute settings. Read More

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Cardiac Rehabilitation in Advanced aGE after PCI for acute coronary syndromes: predictors of exercise capacity improvement in the CR-AGE ACS study.

Aging Clin Exp Res 2022 Apr 22. Epub 2022 Apr 22.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Background: The positive effect of cardiac rehabilitation (CR) on outcomes after acute coronary syndromes (ACS) is established. Nevertheless, enrollment rates into CR programs remain low, although ACS carry a high risk of functional decline particularly in the elderly.

Aim: We aimed to determine if a multidisciplinary CR improves exercise capacity in an older population discharged after ACS systematically treated with PCI. Read More

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Interdisciplinary collaboration and computer-assisted home healthcare referral in the emergency department: a retrospective cohort study.

Aging Clin Exp Res 2022 Apr 20. Epub 2022 Apr 20.

Department of Emergency Medicine, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan, 710, Taiwan.

Aim: Home healthcare (HHC) provides continuous care for disabled patients. However, HHC referral after the emergency department (ED) discharge remains unclear. Thus, this study aimed its clarification. Read More

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Prediction of post-stroke cognitive impairment by Montreal Cognitive Assessment (MoCA) performances in acute stroke: comparison of three normative datasets.

Aging Clin Exp Res 2022 Apr 20. Epub 2022 Apr 20.

Neurology Unit, Luigi Sacco University Hospital, Milan, Italy.

Background: Cognitive assessment in acute stroke is relevant for identifying patients at risk of persistent post-stroke cognitive impairment (PSCI). Despite preliminary evidence on MoCA accuracy, there is no consensus on its optimal score in the acute stroke setting to predict PSCI.

Aims: (1) To explore whether the application of different normative datasets to MoCA scores obtained in the acute stroke setting results in variable frequency of patients defined as cognitively impaired; (2) to assess whether the normality cut-offs provided by three normative datasets predict PSCI at 6-9 months; (3) to calculate alternative MoCA cut-offs able to predict PSCI. Read More

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Self-reported measures of limitation in physical function in late midlife are associated with incident Alzheimer's disease and related dementias.

Aging Clin Exp Res 2022 Apr 19. Epub 2022 Apr 19.

Department of Health Services, Policy, and Practice, Brown University School of Public Health, 121 S. Main Street Box G-S121-6, Providence, RI, 02912, USA.

Background: Even small improvements in modifiable Alzheimer's disease and related dementias (ADRD) risk factors could lead to a substantial reduction of dementia cases.

Aims: To determine if self-reported functional limitation associates with ADRD symptoms 4-18 years later.

Methods: We conducted a prospective longitudinal study using the Health and Retirement Study of adults aged 51-59 years in 1998 without symptoms of ADRD by 2002 and followed them to 2016. Read More

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Understanding current UK practice for the incidental identification of vertebral fragility fractures from CT scans: an expert elicitation study.

Aging Clin Exp Res 2022 Apr 18. Epub 2022 Apr 18.

Manchester Centre for Health Economics, University of Manchester, Oxford Road, Manchester, UK.

Background: There is an emerging interest in using automated approaches to enable the incidental identification of vertebral fragility fractures (VFFs) on existing medical images visualising the spine.

Aim: To quantify values, and the degree of uncertainty associated with them, for the incidental identification of VFFs from computed tomography (CT) scans in current practice.

Methods: An expert elicitation exercise was conducted to generate point estimates and measures of uncertainty for four values representing the probability of: VFF being correctly reported by the radiologist; the absence of VFF being correctly assessed by the radiologist; being referred for management when a VFF is identified; having a dual-energy X-ray absorptiometry (DXA) scan after general practitioner (GP) referral. Read More

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Comorbidity and osteoporotic fracture: approach through predictive modeling techniques using the OSTEOMED registry.

Aging Clin Exp Res 2022 Apr 18. Epub 2022 Apr 18.

Internal Medicine Service, Hospital Universitario Río Hortega, Valladolid, Spain.

Purpose: To examine the response to anti-osteoporotic treatment, considered as incident fragility fractures after a minimum follow-up of 1 year, according to sex, age, and number of comorbidities of the patients.

Methods: For this retrospective observational study, data from baseline and follow-up visits on the number of comorbidities, prescribed anti-osteoporotic treatment and vertebral, humerus or hip fractures in 993 patients from the OSTEOMED registry were analyzed using logistic regression and an artificial network model.

Results: Logistic regression showed that the probability of reducing fractures for each anti-osteoporotic treatment considered was independent of sex, age, and the number of comorbidities, increasing significantly only in males taking vitamin D (OR = 7. Read More

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Late-onset epilepsy and the risk of dementia: a systematic review and meta-analysis.

Aging Clin Exp Res 2022 Apr 15. Epub 2022 Apr 15.

Department of Neurology, The First People's Hospital of Yibin, No. 65 Wenxing Street, Cuiping District, Yibin City, 644000, Sichuan, China.

Background: Patients with dementia have higher risk of epilepsy. However, it remains not comprehensively evaluated if late-onset epilepsy (LOE) is associated with higher risk of dementia. We, therefore, performed a meta-analysis to systematically evaluate the association. Read More

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The use of anticholinergic medication is associated with an increased risk of stroke-associated pneumonia.

Aging Clin Exp Res 2022 Apr 13. Epub 2022 Apr 13.

Department of Neurology, Jagiellonian University Medical College, ul. Botaniczna 3, 31-503, Kraków, Poland.

Background: Pneumonia is a frequent medical complication after stroke. A few studies showed that the use of anticholinergic medication is associated with a higher risk of community acquired pneumonia in the elderly. We aimed to determine if there is any association between anticholinergic medication used before stroke and stroke-associated pneumonia (SAP). Read More

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Prevalence and features of delirium in older patients admitted to rehabilitation facilities: a multicenter study.

Aging Clin Exp Res 2022 Apr 8. Epub 2022 Apr 8.

School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Background: Delirium is thought to be common across various settings of care; however, still little research has been conducted in rehabilitation.

Aim: We investigated the prevalence of delirium, its features and motor subtypes in older patients admitted to rehabilitation facilities during the three editions of the "Delirium Day project".

Methods: We conducted a cross-sectional study in which 1237 older patients (age ≥ 65 years old) admitted to 50 Italian rehabilitation wards during the three editions of the "Delirium Day project" (2015 to 2017) were included. Read More

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Handgrip strength predicts length of hospital stay in an abdominal surgical setting: the role of frailty beyond age.

Aging Clin Exp Res 2022 Apr 7;34(4):811-817. Epub 2022 Apr 7.

Section of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Background: Chronological age per se cannot be considered a prognostic risk factor for outcomes after elective surgery, whereas frailty could be. A simple and easy-to-get marker for frailty, such as handgrip strength (HGS), may support the surgeon in decision for an adequate healthcare plan.

Aims: The aims of this study were to: (1) determine the prevalence of frailty in an abdominal surgery setting independent of age; (2) evaluate the predictive validity of HGS for the length of hospital stay (LOS). Read More

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Effects of automatic mechanical peripheral stimulation on gait biomechanics in older adults with Parkinson's disease: a randomized crossover clinical trial.

Aging Clin Exp Res 2022 Apr 6. Epub 2022 Apr 6.

Department of Physical Education, São Paulo State University, UNESP, Bauru, Brazil.

Background: Automated mechanical peripheral stimulation (AMPS) is a rehabilitation technique suggested to correct gait abnormalities on Parkinson's disease. Although previous studies have suggested increments in functional performance and gait speed after AMPS intervention, little is known about its effect on gait biomechanics.

Objective: To analyze the effect of an AMPS session on functional performance and gait biomechanics in subjects with Parkinson's disease. Read More

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Implementation of the frailty assessment to improve liver transplant outcomes.

Aging Clin Exp Res 2022 Apr 5. Epub 2022 Apr 5.

Hepatology and Gastroenterology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

The majority of patients undergoing Orthotopic Liver Transplantation (OLT) have increased in age, therefore chronological age may have become an unreliable parameter for supporting clinical decisions. The age-related deficit accumulation model measuring frailty proposed by Rockwood et al., may propose an alternative in providing an estimate of an individual's biological age. Read More

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Prognosis of dementia patients with hip fracture surgery.

Authors:
Tomoyuki Kawada

Aging Clin Exp Res 2022 Apr 4. Epub 2022 Apr 4.

Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo, 113-8602, Japan.

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Incidence of fractures and clinical profile of patients following up at a Fracture Liaison Service in the city of Curitiba.

Aging Clin Exp Res 2022 Apr 1. Epub 2022 Apr 1.

Endocrine Division (SEMPR), Federal University of Paraná, Curitiba, Paraná, Brazil.

Background: Osteoporotic fractures are common, and their incidence are increasing worldwide. The first fracture doubles the risk of new fractures. Despite that, up to 80% of patients with a fragility fracture are evaluated or treated to reduce the risk of new fractures. Read More

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The associations of serum valine with mild cognitive impairment and Alzheimer's disease.

Aging Clin Exp Res 2022 Apr 1. Epub 2022 Apr 1.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Chongqing, 400016, China.

Background: The introduction of metabolomics makes it possible to study the characteristic changes of peripheral metabolism in Alzheimer's disease (AD). Recent studies have found that the levels of valine are related to mild cognitive impairment (MCI) and AD.

Aims: This study aimed to further clarify the characteristics of valine levels in MCI and AD. Read More

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The associations of psoas and masseter muscles with sarcopenia and related adverse outcomes in older trauma patients: a retrospective study.

Aging Clin Exp Res 2022 Mar 31. Epub 2022 Mar 31.

Department of Medicine for the Elderly, St Mary's Hospital, Mary Stanford Wing Praed Street, London, W2 1NY, UK.

Background: There is an emerging role for radiological evaluation of psoas muscle as a marker of sarcopenia in trauma patients. Older trauma patients are more likely to undergo cranial than abdomino-pelvic imaging. Identifying sarcopenia using masseter cross-sectional area (M-CSA) has shown correlation with mortality. Read More

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