433,994 results match your criteria Aging & mental health[Journal]


Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.

Brain 2020 May 28. Epub 2020 May 28.

Departments of Physiology and Cell Biology, Brain and Cognitive Sciences, The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Repetitive mild traumatic brain injury in American football players has garnered increasing public attention following reports of chronic traumatic encephalopathy, a progressive tauopathy. While the mechanisms underlying repetitive mild traumatic brain injury-induced neurodegeneration are unknown and antemortem diagnostic tests are not available, neuropathology studies suggest a pathogenic role for microvascular injury, specifically blood-brain barrier dysfunction. Thus, our main objective was to demonstrate the effectiveness of a modified dynamic contrast-enhanced MRI approach we have developed to detect impairments in brain microvascular function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awaa140DOI Listing

Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA.

Altered adipose tissue may contribute to the longevity of Snell dwarf and growth hormone receptor (GHR) knock-out mice. We report here that white (WAT) and brown (BAT) fat have elevated UCP1 in both kinds of mice, and that adipocytes in WAT depots turn beige/brown. These imply increased thermogenesis and are expected to lead to improved glucose control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103380DOI Listing

Klotho alleviates indoxyl sulfate-induced heart failure and kidney damage by promoting M2 macrophage polarization.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of General Practice, Zhejiang Hospital, Hangzhou 310013, Zhejiang, P.R. China.

Indoxyl sulfate (IS) is a protein-bound uremic toxin that can accumulate in patients with chronic kidney disease (CKD) or acute kidney injury (AKI) and cause kidney and cardiac dysfunction. Klotho is an anti-aging protein that has reno- and cardio-protective effects. We investigated whether Klotho could alleviate IS-induced heart failure and kidney damage by regulating macrophages, which play a key role in the inflammatory response in CKD and AKI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103183DOI Listing

Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, P.R. China.

Circular RNAs (circRNAs) play an important role in the tumorigenesis of hepatocellular carcinoma (HCC), but their specific functions in HCC remain largely unknown. Using bioinformatics analysis, we have found that the expression of circRNA hsa_circ_0003141 is significantly increased in HCC tissues. Ubiquitin-associated protein 2 (UBAP2) is the parent gene for hsa_circ_0003141, and its high expression correlates with poor overall survival rates in HCC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103244DOI Listing

Association between central sleep apnea and atrial fibrillation/flutter in Japanese-American men: The Kuakini Honolulu Heart Program (HHP) and Honolulu-Asia Aging Study (HAAS).

J Electrocardiol 2020 May 12;61:10-17. Epub 2020 May 12.

University of Hawai'i at Mānoa, Department of Geriatric Medicine, John A. Burns School of Medicine, 347 N Kuakini St, Honolulu, HI, USA; Kuakini Medical Center, 347 N Kuakini St, Honolulu, HI, USA. Electronic address:

Introduction: While several studies have indicated that central sleep apnea (CSA) is associated with atrial fibrillation and atrial flutter (AF) in older populations, few studies have focused on older Asian populations.

Methods: We conducted a cross- sectional analysis using data from the 1999-2000, 7th exam cycle of the Kuakini Honolulu-Asia Aging Study. Participants were 718 Japanese-American men between 79 and 97 years old, who had overnight polysomnography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jelectrocard.2020.05.005DOI Listing

Age-dependent effect of APOE and polygenic component on Alzheimer's disease.

Neurobiol Aging 2020 Apr 30;93:69-77. Epub 2020 Apr 30.

UK Dementia Research Institute at Cardiff University, Cardiff, United Kingdom; UK Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. Electronic address:

Alzheimer's disease (AD) is a devastating neurodegenerative condition with significant genetic heritability. Several genes have been implicated in the onset of AD with the apolipoprotein E (APOE) gene being the strongest single genetic risk loci. Evidence suggests that the effect of APOE alters with age during disease progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.024DOI Listing

Strategy to improve gold nanoparticles loading efficiency on defect-free high silica ZSM-5 zeolite for the reduction of nitrophenols.

Chemosphere 2020 May 16;256:127083. Epub 2020 May 16.

College of Resources and Environmental Sciences, Hunan Normal University, Changsha, Hunan, 410082, PR China.

Catalytic reduction of toxic and aqueous stable nitrophenols by gold nanoparticles (Au NPs) is hot issue due to the serious environmental pollution in recent years. But the expensive price and poor recycling performance of Au NPs limit its further application. Defect-free high silica zeolite is suitable support for Au NPs due to its cheaper price, higher stability and stronger adsorbability, but the low alumina content and defect sites usually lead to poor Au NPs loading efficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.127083DOI Listing

A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain.

Neuroimage 2020 May 25:116976. Epub 2020 May 25.

Department of Neuroscience, Psychology & Behaviour, University of Leicester, Leicester, UK; School of Psychology, University of Nottingham, Nottingham, UK. Electronic address:

As the population ages, the incidence of age-related neurological diseases and cognitive decline increases. To further understand disease-related changes in brain function it is advantageous to examine brain activity changes in healthy aging rodent models to permit mechanistic investigation. Here, we examine the suitability, in rodents, of using a novel, minimally invasive anaesthesia protocol in combination with a functional MRI protocol to assess alterations in neuronal activity due to physiological aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2020.116976DOI Listing

Timing of anti-osteoporosis medications initiation after a hip fracture affects the risk of subsequent fracture: A nationwide cohort study.

Bone 2020 May 25:115452. Epub 2020 May 25.

School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Objective: The optimal time after hip fracture to start prophylactic anti-osteoporosis medications (AOMs) remains uncertain, especially in real-world practice. Therefore, we investigated how AOMs initiation timing affects the risk of subsequent osteoporotic fractures, and what factors influence AOMs prescription timing.

Method: Patients ≥50 years old with diagnostic codes indicating hospitalization for hip fracture (n = 77,930) were sampled from the Taiwan National Health Insurance Research Database; 9986 who were prescribed AOMs ≤1 year after a newly-diagnosed hip fracture were grouped into those who started AOMs from: ≤14 days (early); 15-84 days (very early); 85-252 days (late); and 253-365 days (very late). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2020.115452DOI Listing

Decellularized Tissues as Platforms for In Vitro Modeling of Healthy and Diseased Tissues.

Acta Biomater 2020 May 25. Epub 2020 May 25.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. BMS J257, Gainesville, FL USA 32611. Electronic address:

Biomedical engineers are at the forefront of developing novel treatments to improve human health, however, many products fail to translate to clinical implementation. In vivo pre-clinical animal models, although the current best approximation of complex disease conditions, are limited by reproducibility, ethical concerns, and poor accurate prediction of human response. Hence, there is a need to develop physiologically relevant, low cost, scalable, and reproducible in vitro platforms to provide reliable means for testing drugs, biomaterials, and tissue engineered products for successful clinical translation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2020.05.031DOI Listing

The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouse.

Exp Gerontol 2020 May 25:110975. Epub 2020 May 25.

Department of Histology and Embryology, Akdeniz University School of Medicine, Antalya, Turkey. Electronic address:

Telomeres are repetitive DNA sequences localized at the ends of eukaryotic chromosomes, and shorten during ovarian aging. The molecular background of telomere shortening during ovarian aging is not fully understood. As the telomerase components (TERT and Terc) and telomere-associated proteins (TRF1, TRF2, and POT1a) play key roles in the elongation and maintenance of telomeres, we aimed to determine their spatial and temporal expression and cellular localization in the mouse ovaries at the different ages of postnatal life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2020.110975DOI Listing

Prevalence of muscle dysfunction concomitant with osteoporosis in a home-dwelling Danish population aged 65-93 years - The Copenhagen Sarcopenia Study.

Exp Gerontol 2020 May 25:110974. Epub 2020 May 25.

Geriatric Research Unit, Department of Geriatric Medicine, Bispebjerg and Frederiksberg University Hospital, Denmark; Geriatric Research Unit, Department of Geriatric Medicine, Herlev and Gentofte University Hospital, Denmark; Faculty of Medical and Health Sciences, Copenhagen University, Denmark.

Introduction: As life expectancy increases, a growing percentage of older individuals with age-related diseases such as osteoporosis and sarcopenia are expected. Patients with both conditions, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2020.110974DOI Listing

Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-κB pathway.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Jiangsu 215000, China.

Inflammation is an important cause of chronic obstructive pulmonary disease (COPD) and its acute exacerbation. However, the critical role of C-C chemokine receptor (CCR)1 in progression of cigarette smoke-induced chronic inflammation remains unclear. We studied CCR1 expression using immunohistochemistry, immunofluorescence, and real-time polymerase chain reaction (RT-PCR) in COPD patients and controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103180DOI Listing

miR-378a-3p inhibits ischemia/reperfusion-induced apoptosis in H9C2 cardiomyocytes by targeting TRIM55 via the DUSP1-JNK1/2 signaling pathway.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.

MicroRNAs (miRNAs) are involved in many pathological and biological processes, such as ischemia/reperfusion (I/R) injury by modulating gene expression. Increasing evidence indicates that miR-378a-3p might provide a potential cardioprotective effect against ischemic heart disease. Cell apoptosis is a crucial mechanism in I/R injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103106DOI Listing

Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19.

Aging (Albany NY) 2020 May 27;12. Epub 2020 May 27.

Program Against Cancer Therapeutic Resistance (ProCURE), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, Spain.

Pathological signaling in the lung induced by particulate matter (PM) air pollution partially overlaps with that provoked by COVID-19, the pandemic disease caused by infection with the novel coronavirus SARS-CoV-2. Metformin is capable of suppressing one of the molecular triggers of the proinflammatory and prothrombotic processes of urban PM air pollution, namely the mitochondrial ROS/Ca release-activated Ca channels (CRAC)/IL-6 cascade. Given the linkage between mitochondrial functionality, ion channels, and inflamm-aging, the ability of metformin to target mitochondrial electron transport and prevent ROS/CRAC-mediated IL-6 release might illuminate new therapeutic avenues to quell the raging of the cytokine and thrombotic-like storms that are the leading causes of COVID-19 morbidity and mortality in older people. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103347DOI Listing

HIX003209 promotes vascular smooth muscle cell migration and proliferation through modulating miR-6089.

Aging (Albany NY) 2020 May 27;12. Epub 2020 May 27.

Neurosurgery Department, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning, People's Republic of China.

Accumulating references have showed that long noncoding RNAs (lncRNAs) act important roles in the development of human diseases. The role and expression of HIX003209 remains unclear in the pathogenesis of atherosclerosis. We showed that HIX003209 expression was upregulated in atherosclerotic coronary tissues compared to normal coronary artery samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103079DOI Listing

Prognostic value of prostaglandin I2 synthase and its correlation with tumor-infiltrating immune cells in lung cancer, ovarian cancer, and gastric cancer.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Gynecology and Obstetrics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong, China.

Background: Prostaglandin I2 synthase (PTGIS) is a crucial gene for the synthesis of prostaglandin I2, which has multiple roles in inflammation and immune modulation. However, studies on the prognostic value of PTGIS and its correlation with tumor-infiltrating immune cells in multiple cancers are still rare.

Results: Multiple datasets of the Oncomine database showed that PTGIS was expressed at low levels in lung cancer and ovarian cancer compared to the levels in normal tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103235DOI Listing

Valproic acid-labeled chitosan nanoparticles promote recovery of neuronal injury after spinal cord injury.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China.

Chitosan nanoparticles have been recognized as a new type of biomaterials for treatment of spinal cord injury (SCI). To develop a novel treatment method targeted delivery injured spinal cord, valproic acid labeled chitosan nanoparticles (VA-CN) were constructed and evaluated in the treatment of SCI. Our results demonstrated that administration of VA-CN significantly promoted the recovery of the function and tissue repair after SCI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103125DOI Listing

Influence of human amylin on the membrane stability of rat primary hippocampal neurons.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Pharmacology, Institution of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang, Hebei, China.

The two most common aging-related diseases, Alzheimer's disease and type 2 diabetes mellitus, are associated with accumulation of amyloid proteins (β-amyloid and amylin, respectively). This amylin aggregation is reportedly cytotoxic to neurons. We found that aggregation of human amylin (hAmylin) induced neuronal apoptosis without obvious microglial infiltration . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103105DOI Listing

Altered glucocorticoid metabolism represents a feature of macroph-aging.

Aging Cell 2020 May 28:e13156. Epub 2020 May 28.

Pharmaceutical Biology, Department of Pharmacy, Saarland University, Saarbrücken, Germany.

The aging process is characterized by a chronic, low-grade inflammatory state, termed "inflammaging." It has been suggested that macrophage activation plays a key role in the induction and maintenance of this state. In the present study, we aimed to elucidate the mechanisms responsible for aging-associated changes in the myeloid compartment of mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.13156DOI Listing

Fragile X Gray Zone Alleles Are Associated With Signs of Parkinsonism and Earlier Death.

Mov Disord 2020 May 28. Epub 2020 May 28.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

Background: Premutation size (55-199 CGG repeats) in the fragile X mental retardation 1 (FMR1) gene cause fragile X-associated tremor/ataxia syndrome, but it is unclear whether smaller "gray" zone expansions of 41-54 repeats are also associated with movement disorders. The objectives of this study were to determine the association between the FMR1 gene gray zone expansions, AGG interspersions, and the presence of parkinsonism and motor and cognitive function in an elderly community-based population.

Methods: Automated FMR1 polymerase chain reaction was performed on existing samples from 2 longitudinal aging studies whose subjects agreed to brain donation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.28086DOI Listing

Readability Analysis of Online Headache and Migraine Information.

Headache 2020 May 28. Epub 2020 May 28.

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: Although migraine is recognized as one of the most common and disabling diseases in the world, it is nonetheless still underestimated, underdiagnosed, and undertreated. The fact that migraine patients often tend to access the Web to search for headache-related information hinders patient-doctor relationships and one should also bear in mind that, unfortunately, text readability and medical literacy in the overall population may be the reason why patients' understanding of health information is compromised.

Aim: We aimed to assess the readability of the home page of the top 10 patient - oriented migraine-related websites and the educational level required to be in a position to broach them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/head.13818DOI Listing

Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial.

JAMA Netw Open 2020 May 1;3(5):e206027. Epub 2020 May 1.

Department of Psychiatry, University Hospital Cologne, Medical Faculty, Cologne, Germany.

Importance: Apathy is a frequent neuropsychiatric symptom in dementia of Alzheimer type and negatively affects the disease course and patients' and caregivers' quality of life. Effective treatment options are needed.

Objective: To examine the efficacy and safety of the dopamine and noradrenaline reuptake inhibitor bupropion in the treatment of apathy in patients with dementia of Alzheimer type. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2020.6027DOI Listing

Analysis of Overall Survival Benefit of Abemaciclib Plus Fulvestrant in Hormone Receptor-Positive, ERBB2-Negative Breast Cancer.

JAMA Oncol 2020 May 28. Epub 2020 May 28.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2020.1513DOI Listing

Age-related changes to the satellite cell niche are associated with reduced activation following exercise.

FASEB J 2020 May 28. Epub 2020 May 28.

Department of Kinesiology, McMaster University, Hamilton, ON, Canada.

Skeletal muscle satellite cell (SC) function and responsiveness is regulated, in part, through interactions within the niche, in which they reside. Evidence suggests that structural changes occur in the SC niche as a function of aging. In the present study, we investigated the impact of aging on SC niche properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201900787RDOI Listing

Development of an UPSA Short Form for Use in Longitudinal Studies in the Early Alzheimer's Disease Spectrum.

J Prev Alzheimers Dis 2020 ;7(3):179-183

Dr. Jesus J. Gomar, Litwin-Zucker Alzheimer's Disease Center, Feinstein Institute, Manhassett, NY, USA, Email: Telephone: 516-562-0420, Fax: 516-562-0401.

Background: In individuals with only mild or very mild cognitive attenuations (i.e., so-called pre-clinical AD), performance-based measures of function may be superior to informant-based measures because of increased sensitivity, greater reliability, and fewer ceiling effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14283/jpad.2019.51DOI Listing
January 2020

Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting.

J Prev Alzheimers Dis 2020 ;7(3):171-178

Marwan N. Sabbagh, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA, Tel.: (702) 483-6029; Fax: (702) 722-6584.

Emerging digital tools have the potential to enable a new generation of qualitative and quantitative assessment of cognitive performance. Moreover, the ubiquity of consumer electronics, such as smartphones and tablets, can be harnessed to support large-scale self-assessed cognitive screening with benefit to healthcare systems and consumers. A wide variety of apps, wearables, and new digital technologies are either available or in development for the detection of mild cognitive impairment (MCI), a risk factor for dementia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14283/jpad.2020.22DOI Listing
January 2020

Early Detection of Mild Cognitive Impairment (MCI) in Primary Care.

J Prev Alzheimers Dis 2020 ;7(3):165-170

Marwan N. Sabbagh, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA, Tel.: (702) 483-6029; Fax: (702) 722-6584.

Mild cognitive impairment (MCI) is significantly misdiagnosed in the primary care setting due to multi-dimensional frictions and barriers associated with evaluating individuals' cognitive performance. To move toward large-scale cognitive screening, a global panel of clinicians and cognitive neuroscientists convened to elaborate on current challenges that hamper widespread cognitive performance assessment. This report summarizes a conceptual framework and provides guidance to clinical researchers and test developers and suppliers to inform ongoing refinement of cognitive evaluation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14283/jpad.2020.21DOI Listing
January 2020

Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) Supported by Emerging Digital Technologies.

J Prev Alzheimers Dis 2020 ;7(3):158-164

Marwan N. Sabbagh, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA, Tel.: (702) 483-6029; Fax: (702) 722-6584.

Disease-modifying pharmacotherapies for Alzheimer's Disease (AD) are currently in late-stage clinical development; once approved, new healthcare infrastructures and services, including primary healthcare, will be necessary to accommodate a huge demand for early and large-scale detection of AD. The increasing global accessibility of digital consumer electronics has opened up new prospects for early diagnosis and management of mild cognitive impairment (MCI) with particular regard to AD. This new wave of innovation has spurred research in both academia and industry, aimed at developing and validating a new "digital generation" of tools for the assessment of the cognitive performance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14283/jpad.2020.19DOI Listing
January 2020

Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report.

J Prev Alzheimers Dis 2020 ;7(3):152-157

Serge Gauthier, McGill Center for Studies in Aging, Verdun QC, Canada,

While amyloid-targeting therapies continue to predominate in the Alzheimer's disease (AD) drug development pipeline, there is increasing recognition that to effectively treat the disease it may be necessary to target other mechanisms and pathways as well. In December 2019, The EU/US CTAD Task Force discussed these alternative approaches to disease modification in AD, focusing on tau-targeting therapies, neurotrophin receptor modulation, anti-microbial strategies, and the innate immune response; as well as vascular approaches, aging, and non-pharmacological approaches such as lifestyle intervention strategies, photobiomodulation and neurostimulation. The Task Force proposed a general strategy to accelerate the development of alternative treatment approaches, which would include increased partnerships and collaborations, improved trial designs, and further exploration of combination therapy strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14283/jpad.2020.18DOI Listing
January 2020

Factors that influence marital satisfaction in men with a heart rhythm disorders.

Aging Male 2020 May 28:1-7. Epub 2020 May 28.

Department of Electrocardiology, Upper Silesian Medical Centre, Katowice, Poland.

: A diagnosis of a cardiac arrhythmia can affect marital relations and diminish libido and satisfaction with a patient's sex life. The aim of the study was to assess the factors that affect marital satisfaction in men with an arrhythmias who had qualified for cardiac pacemaker implantation. The study included 103 men (aged 58. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13685538.2020.1770211DOI Listing

Alterations of local functional connectivity in lifespan: A resting-state fMRI study.

Brain Behav 2020 May 27:e01652. Epub 2020 May 27.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

Introduction: As aging attracted attention globally, revealing changes in brain function across the lifespan was largely concerned. In this study, we aimed to reveal the changes of functional networks of the brain (via local functional connectivity, local FC) in lifespan and explore the mechanism underlying them.

Materials And Methods: A total of 523 healthy participants (258 males and 265 females) aged 18-88 years from part of the Cambridge Center for Ageing and Neuroscience (CamCAN) were involved in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/brb3.1652DOI Listing

EUS Ablation in a Patient with Multiple Metastatic Pancreatic Tumors from ACTH-producing Thymic Neuroendocrine Neoplasm.

Dig Endosc 2020 May 27. Epub 2020 May 27.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Adrenocorticotropic hormone (ACTH)-producing neuroendocrine neoplasm (NEN) of the thymus is rare. Lymph nodes and bones are the most common metastatic sites. Most cases present with florid Cushing's syndrome (CS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/den.13752DOI Listing

COVID-19: Consider IL6 receptor antagonist for the therapy of cytokine storm syndrome in SARS-CoV-2 infected patients.

J Med Virol 2020 May 28. Epub 2020 May 28.

College of Pharmacy and Health Care, Tajen University, Yanpu, Pingtung, 907, Taiwan, China.

COVID-19 leads to mortality of several patients and the cytokine storm is reportedly critical in the patients. In order to reduce the cytokine storm, we would like to propose the IL6 receptor antagonist therapy for the COVID-19 patients. Two humanized monoclonal antibodies are in clinical trial following IL6R antagonist therapies namely tocilizumab and sarilumab. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.26078DOI Listing

Thermal and Reactive Oxygen Species Dual-Responsive OEGylated Polysulfides with Oxidation-Tunable Lower Critical Solution Temperatures.

Macromol Rapid Commun 2020 May 27:e2000206. Epub 2020 May 27.

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China.

In this work, two monomethoxy oligo(ethylene glycol) (OEG)-substituted episulfides are prepared and a series of polysulfides are synthesized with subsequent ring-opening polymerization. The OEGylated polysulfides exhibit thermal and reactive oxygen species (ROS) dual-responsive behavior. Their lower critical solution temperatures (LCSTs) are close to human body temperature and depend on the degree of polymerization and OEG length. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/marc.202000206DOI Listing

The impact of airborne pollution and exposure to solar ultraviolet radiation on skin: mechanistic and physiological insight.

Environ Sci Pollut Res Int 2020 May 27. Epub 2020 May 27.

Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.

For several decades air pollution has been recognized to hit drastically the skin of human body. Air pollutants predominantly accountable for aging, oxidative damage, and inflammatory allergic reactions led to psoriasis, dermatitis, acne, and skin cancer owing to the impaired functions of DNA, proteins, and lipid biomolecules. Elevated air pollution and its detrimental effects along with variations in physiological parameters of the skin are verily the scaffold for anti-pollution assertions and could be recognized as markers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-020-09280-4DOI Listing

An Immersive Simulation to Build Empathy for Geriatric Patients with Co-Occurring Physical and Mental Illness.

Acad Psychiatry 2020 May 27. Epub 2020 May 27.

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Objective: The objective of the study was to explore the effectiveness of an immersive simulation experience using an aging simulation suit for fostering empathy towards geriatric patients with advanced mental illness.

Method: Psychiatry residents were recruited during their clinical rotations at a Canadian mental health hospital. The participants took on the first-person perspective of a geriatric patient with mental illness initially through written reflection, and then physically inhabited this role by wearing an aging simulation suit to perform the task of meeting with a pharmacist to review current medications and prepare a dosette. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40596-020-01233-wDOI Listing

Gender differences in the association between physical activity and health-related quality of life among community-dwelling elders.

Aging Clin Exp Res 2020 May 27. Epub 2020 May 27.

Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei City, Taiwan (R.O.C.).

Background: Physical activity can improve health-related quality of life (HRQoL) in older adults. However, the differential effects of gender on quality of life are unclear.

Aims: To determine the association between physical activity and HRQoL in men and women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40520-020-01597-xDOI Listing

A Randomized, Double-Blind, Split-Body, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Tolerability of a Topical Body Firming Moisturizer for Upper Arm Rejuvenation.

Aesthet Surg J 2020 May 28. Epub 2020 May 28.

Background: Skin aging of upper arm, induced by intrinsic and extrinsic factors, often results in loss of contour, elasticity and firmness, and increase in laxity, crepiness, roughness and photodamage. A topical body firming moisturizer (TBFM) was developed to target all aspects of aged body skin.

Objective: The aim of this study was to evaluate the efficacy and tolerability of the TBFM for upper arm firming and rejuvenation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/asj/sjaa134DOI Listing

The Temporal Window of Visual Processing in Aging.

Invest Ophthalmol Vis Sci 2020 May;61(5):60

,.

Purpose: Aging affects a variety of visual functions. In this study, we aim to quantitatively investigate the temporal characteristics of visual processing in aging.

Methods: Twelve younger (24. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.61.5.60DOI Listing

The Status of Specialized Ambulatory Heart Failure Care in Canada: A Joint Canadian Heart Failure Society and Canadian Cardiovascular Society Heart Failure Guidelines Survey.

CJC Open 2020 May 7;2(3):151-160. Epub 2020 Mar 7.

Memorial University, St John's, Newfoundland, Canada.

This joint Canadian Heart Failure Society and the CCS Heart Failure guidelines report has been developed to provide a pan-Canadian snapshot of the current state of clinic-based ambulatory heart failure (HF) care in Canada with specific reference to elements and processes of care associated with quality and high performing health systems. It includes the viewpoints of persons with lived experience, patient care providers, and administrators. It is imperative to build on the themes identified in this survey, through engaging all health care professionals, to develop integrated and shared care models that will allow better patient outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjco.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242502PMC

Remodeling of the H3 nucleosomal landscape during mouse aging.

Transl Med Aging 2020 3;4:22-31. Epub 2020 Jan 3.

Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and deregulation of gene expression correlates with aging. A key layer in the study of gene regulation mechanisms lies at the level of chromatin: cellular chromatin states (. the 'epigenome') can tune transcriptional profiles, and, in line with the prevalence of transcriptional alterations with aging, accumulating evidence suggests that the chromatin landscape is altered with aging across cell types and species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tma.2019.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252472PMC
January 2020

Two Time Point Analysis of the Change in Risk and Aging Factors for Major Cancers: A 10-Year Longitudinal Study in China.

Authors:
Liu Hui

Biomed Res Int 2020 6;2020:9043012. Epub 2020 May 6.

Department of Clinical Immunology, Dalian Medical University, Dalian 116044, China.

Objective: To quantify the change in risk and aging factors with a two time point analysis for major cancers to assess supportive strategies.

Methods: The 2004 and 2015 mortality statistics in China were accessed. The standardized mortality rates of the two periods were used to calculate the ratio of change (RC) value to assess the risk of death associated with time (social development with time) for cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/9043012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229547PMC

Convergence Science to Transform Biomedicine: A Narrative Review.

Iran J Public Health 2020 Feb;49(2):221-229

Department of Basic Sciences, Iranian Academy of Medical Sciences, Tehran, Iran.

Recently convergence science was proposed and promoted in a large report from US National Science Foundation and Department of Commerce (NSF/DOC). The report was entitled "converging technologies for improving human performance. ". Read More

View Article

Download full-text PDF

Source
February 2020

Simulation of organic aerosol formation during the CalNex study: updated mobile emissions and secondary organic aerosol parameterization for intermediate-volatility organic compounds.

Atmos Chem Phys 2020 Apr;20(7):4313-4332

Center of Atmospheric Particle Studies, Carnegie Mellon University, Pittsburgh, PA, USA.

We describe simulations using an updated version of the Community Multiscale Air Quality model version 5.3 (CMAQ v5.3) to investigate the contribution of intermediate-volatility organic compounds (IVOCs) to secondary organic aerosol (SOA) formation in southern California during the CalNex study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5194/acp-20-4313-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252505PMC

Structures of α-synuclein filaments from multiple system atrophy.

Nature 2020 May 27. Epub 2020 May 27.

MRC Laboratory of Molecular Biology, Cambridge, UK.

Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease, Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human neurodegenerative diseases. Existing treatments are at best symptomatic. These diseases are characterized by the presence of, and believed to be caused by the formation of, filamentous inclusions of α-synuclein in brain cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-020-2317-6DOI Listing

Relevance of oxidative stress and inflammation in frailty based on human studies and mouse models.

Aging (Albany NY) 2020 May 27;12. Epub 2020 May 27.

Group of Cellular Oncology, Biodonostia Health Research Institute, San Sebastian, Spain.

Frailty represents a state of vulnerability and increases the risk of negative health outcomes, which is becoming an important public health problem. Over recent years, multiple independent studies have attempted to identify biomarkers that can predict, diagnose, and monitor frailty at the biological level. Among them, several promising candidates have been associated with frailty status including antioxidants and free radicals, and also inflammatory response biomarkers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103295DOI Listing

Systematic metabolic analysis of potential target, therapeutic drug, diagnostic method and animal model applicability in three neurodegenerative diseases.

Aging (Albany NY) 2020 May 27;12. Epub 2020 May 27.

Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China.

Considerable evidence suggests that metabolic abnormalities are associated with neurodegenerative diseases. This study aimed to conduct a systematic metabolic analysis of Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Human and mouse model microarray datasets were downloaded from the Gene Expression Omnibus database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103253DOI Listing

Long noncoding RNA lnc-LOC645166 promotes adriamycin resistance via NF-κB/GATA3 axis in breast cancer.

Aging (Albany NY) 2020 May 27;12. Epub 2020 May 27.

Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.

Chemoresistance remains a significant obstacle for effective adriamycin (ADR) treatment in breast cancer. Recent efforts have revealed that long noncoding RNAs (lncRNAs) play a crucial role in cancer biology, including chemoresistance. We identified the lncRNA LOC645166 was upregulated in adriamycin resistant-breast cancer cells by Microarray analysis, which was further confirmed in the tissues of nonresponsive patients by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), western blotting, and immunohistochemical assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103012DOI Listing

Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches.

Proc Natl Acad Sci U S A 2020 May 27. Epub 2020 May 27.

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520;

Networks of branched actin filaments formed by Arp2/3 complex generate and experience mechanical forces during essential cellular functions, including cell motility and endocytosis. External forces regulate the assembly and architecture of branched actin networks both in vitro and in cells. Considerably less is known about how mechanical forces influence the disassembly of actin filament networks, specifically, the dissociation of branches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1911183117DOI Listing