404,660 results match your criteria Aging & mental health[Journal]


Emerging translational science discoveries, clonal approaches and treatment trends in chronic myeloproliferative neoplasms.

Hematol Oncol 2019 Apr 23. Epub 2019 Apr 23.

University of California Irvine, Irvine, CA, USA.

The 60 American Society of Hematology (ASH) held in San Diego in December 2018 was followed by the 13 Post-ASH chronic myeloproliferative neoplasms (MPNs) workshop on the 4 -5 December 2018. This closed annual workshop, first introduced in 2006 by Goldman and Mughal, was organized in collaboration with Alpine Oncology Foundation and allowed experts in preclinical and clinical research in the chronic MPNs to discuss the current scenario, including relevant presentations at ASH, and address pivotal open questions that impact translational research and clinical management. This review is based on the presentations and deliberations at this workshop, and rather than provide a resume of the proceedings, we have selected some of the important translational science and treatment issues which require clarity. Read More

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http://dx.doi.org/10.1002/hon.2622DOI Listing

Biocatalytic Reversal of Advanced Glycation End Product Modification.

Chembiochem 2019 Apr 23. Epub 2019 Apr 23.

Yale, Chemistry and Microbial Pathogenesis, P.O. Box 27392, 06516-7392, West Haven, UNITED STATES.

Advanced glycation end products (AGEs) are a heterogeneous group of molecules that emerge from the condensation of sugars and proteins via the Maillard reaction. Despite a significant number of studies showing strong associations between AGEs and the pathologies of aging-related illnesses, it has been a challenge to establish AGEs as causal agents primarily due to the lack of tools in reversing AGE modifications at the molecular level. Here, we show that MnmC, an enzyme involved in a bacterial tRNA-modification pathway, is capable of reversing the AGEs carboxyethyl-lysine (CEL) and carboxymethyl-lysine (CML) back to their native lysine structure. Read More

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http://dx.doi.org/10.1002/cbic.201900158DOI Listing

Physician and Surrogate Agreement with Assisted Dying and Continuous Deep Sedation in Advanced Dementia in Switzerland.

Neurodegener Dis 2019 Apr 23:1-8. Epub 2019 Apr 23.

University Research Priority Program "Dynamics of Healthy Aging," University of Zurich, Zurich, Switzerland.

Background: Assisted dying and continuous deep sedation (CDS) are controversial practices. Little is known about the perceptions of physicians and surrogates about these practices for patients with advanced dementia.

Objectives: To describe and compare physician and surrogate agreement with the use of assisted dying and CDS in advanced dementia. Read More

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http://dx.doi.org/10.1159/000499113DOI Listing

Cross-Sectional Area Analysis of the Head of the Caudate Nucleus in Huntington's Disease.

Eur Neurol 2019 Apr 23;81(1-2):13-18. Epub 2019 Apr 23.

Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan,

Background: Caudate nucleus atrophy is a well-known neuroimaging feature of Huntington's disease (HD). Some researchers have reported a decrease in the volume of the striatum on magnetic resonance images (MRIs) even in the presymptomatic stage of the disease. Despite the many neuroimaging studies on HD, the optimal method for measuring the caudate nucleus area on MRIs and the most effective cutoff values for diagnosing HD remain unclear. Read More

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http://dx.doi.org/10.1159/000499909DOI Listing

[MASK (Mobile Airways Sentinel Network). ARIA's comprehensive solution for mobile app for the multimorbidity of allergic rhinitis and asthma].

Rev Alerg Mex 2019 Jan-Mar;66(1):140-146

Médica Sur, Centro de Excelencia en Asma y alergia, Ciudad de México, México.

The vast majority of patients with allergic rhinitis (AR) do not receive the proper management which is recommended by the guidelines, but they frequently self-medicate. MASK (Mobile Airways Sentinel Network) is an integral part of a project that is supported by the European Union against chronic diseases and focused on active and healthy aging. MASK represents the third phase of ARIA (Allergic Rhinitis and its Impact on Asthma), in which, by using a mobile application in a smart device, the objective is to guide the patient in the control of his/her multi-morbidity, AR and/or allergic conjunctivitis (AC) and/or asthma. Read More

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http://dx.doi.org/10.29262/ram.v66i1.578DOI Listing

Development of rear-impeller axial-flow blood pump for realization of axial flow blood pump installed at aortic valve position.

Artif Organs 2019 Apr 23. Epub 2019 Apr 23.

Hokkaido University.

In this study, rear-impeller axial-flow blood pumps (RIAFBP) were developed to realize a trans-valve axial ventricular assist device (VAD) which consists of the latter blood pump and a polymer monomembrane aortic valve, such as the jelly-fish valve. The motor of the RIAFBP is installed in the left ventricle, and its impeller is placed at the aortic valve position. In the prototype RIAFBP, the rotation of the motor is sustained by polyethylene bushes. Read More

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http://dx.doi.org/10.1111/aor.13476DOI Listing

Tortuosity of the descending thoracic aorta: Normal values by age.

PLoS One 2019 23;14(4):e0215549. Epub 2019 Apr 23.

Department of Health and Community Sciences, University of Milan, Milan, Italy.

Background: Aging changes the aorta in length, tortuosity and diameter. This is relevant in thoracic endovascular aortic repair (TEVAR) and in the long term follow up.

Methods And Results: Two groups of hundred patients < 65 years and hundred patients ≥ 65 years, with no vascular diseases were made. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215549PLOS
April 2019
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Hearing as an Independent Predictor of Postural Balance in 1075 Patients Evaluated for Dizziness.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819844961. Epub 2019 Apr 23.

1 Norwegian National Advisory Unit on Vestibular Disorders, Haukeland University Hospital, Bergen, Norway.

Objective: To evaluate the association between hearing and postural balance.

Study Design: Retrospective cross-sectional study.

Setting: Tertiary care otolaryngology clinic. Read More

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http://dx.doi.org/10.1177/0194599819844961DOI Listing

The Shifting Architecture of Cognition and Brain Function in Older Adulthood.

Perspect Psychol Sci 2019 Apr 23:1745691619827511. Epub 2019 Apr 23.

2 Department of Psychology, York University.

Cognitive aging is often described in the context of loss or decline. Emerging research suggests that the story is more complex, with older adults showing both losses and gains in cognitive ability. With increasing age, declines in controlled, or fluid, cognition occur in the context of gains in crystallized knowledge of oneself and the world. Read More

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http://dx.doi.org/10.1177/1745691619827511DOI Listing

The psychological and aesthetic impact of age-related hair changes in females.

J Cosmet Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Dermatology, San Diego School of Medicine, University of California, La Jolla, California.

Background: While dermatologists focus on practices to promote anti-aging, thinning hair that frames a more rejuvenated face can affect age perception and cosmesis.

Objectives: To characterize the effects of age-related hair changes on age determination and perceived attractiveness.

Methods: A search was conducted for articles on intrinsic and extrinsic aging as it relates to hair. Read More

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http://dx.doi.org/10.1111/jocd.12960DOI Listing

Systematic Advance Care Planning and Potentially Avoidable Hospitalizations of Nursing Facility Residents.

J Am Geriatr Soc 2019 Apr 23. Epub 2019 Apr 23.

RESPECT (Research in Palliative and End-of-Life Communication and Training) Signature Center, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.

Background/objectives: The Optimizing Patient Transfers, Impacting Medical Quality, Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) project is a successful, multicomponent demonstration project to reduce potentially avoidable hospitalizations of long-stay nursing facility residents. Systematic advance care planning (ACP) is a core component of the intervention, based on research suggesting ACP is associated with decreased hospitalizations of nursing facility residents. The purpose of this study was to describe associations between ACP documentation resulting from the OPTIMISTIC intervention and hospitalizations. Read More

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http://dx.doi.org/10.1111/jgs.15927DOI Listing

Novel Therapies for an Aging Population: Grappling With Price, Value, and Affordability.

JAMA 2019 Apr;321(16):1567-1568

Institute for Clinical & Economic Review, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2019.2633DOI Listing

Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden.

Radiology 2019 Apr 23:182726. Epub 2019 Apr 23.

From the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).

Background Apolipoprotein E4 (APOE4) is a major genetic risk factor for late-onset Alzheimer disease. However, the mechanisms by which APOE4 affects the brain, underpinning this risk, have not been fully elucidated. Purpose To investigate the influence of APOE4 on global cerebral oxygen extraction fraction (OEF) and possible mediation through amyloid burden by using MRI-based brain oxygen extraction technique. Read More

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http://dx.doi.org/10.1148/radiol.2019182726DOI Listing

What Prompts Policy Change? Comparative Analyses of Efforts to Create Age-Friendly Cities in 14 Cities in Indonesia.

J Aging Soc Policy 2019 Apr 23:1-21. Epub 2019 Apr 23.

a SurveyMETER , Yogyakarta , Indonesia.

Four years after an age-friendly city (AFC) assessment across Indonesia, this article presents a comparative analysis of policy changes that have taken place across different AFC dimensions and factors associated with more and less change. Nine of fourteen cities initiated changes, ranging from public declarations, regulations, and creation or expansion of services. Our findings suggest that the AFC assessment can offer a means to engage policy makers, which in turn may facilitate city-level change, particularly for larger cities with more substantive budgets and more consolidated rather than dispersed leadership; however, no single factor represented a sufficient or necessary condition for change. Read More

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http://dx.doi.org/10.1080/08959420.2019.1589889DOI Listing

Aging Significantly Affects Mobility and Contaminant-mobilizing Ability of Nanoplastics in Saturated Loamy Sand.

Environ Sci Technol 2019 Apr 23. Epub 2019 Apr 23.

Plastic debris, in particular, microplastics and nanoplastics, is becoming an emerging class of pollutants of global concern. Aging can significantly affect the physicochemical properties of plastics, and therefore, may influence the fate, transport and effects of these materials. Here, we show that aging by UV or O3 exposure drastically enhanced the mobility and contaminant-mobilizing ability of spherical polystyrene nanoplastics (PSNPs, 487. Read More

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http://dx.doi.org/10.1021/acs.est.9b00787DOI Listing

Red Deer Umbilical Cord Lining Mesenchymal Stem Cell Extract Cream for Rejuvenation of the Face

J Drugs Dermatol 2019 Apr;18(4):363-366

Background: Aging is a multifactorial process that involves all components of the skin. Both intrinsic and extrinsic forces play a role in this aging process. A new patented protein mix derived from red deer umbilical cord lining stem cell conditioned media (Calecim® Multi Action Cream, CellResearch Corporation, Singapore) has been developed to improve the signs of aging. Read More

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[DHEAS/cortisol index as a marker of stress-induced premature aging.]

Klin Lab Diagn 2019 ;64(3):140-144

Federal State Budgetary Institution "The Nikiforov Russian Center of Emergency and Radiation Medicine", the Ministry of the Russian Federation for Civil Defence, Emergencies and Elimination of Consequences of Natural Disasters, 194044, Saint-Petersburg, Russia.

The detection of stress-induced premature aging with the aim of correcting damaging adaptive effects seems to be actual today. The article discusses the use of the DHEAS / cortisol index as a screening marker for accelerating the rate of biological aging in people exposed to stress. Read More

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http://dx.doi.org/10.18821/0869-2084-2019-64-3-140-144DOI Listing
January 2019

Aging and Direct-to-Consumer Prescription Drug Television Ads: The Effects of Individual Differences and Risk Presentation.

J Health Commun 2019 Apr 23:1-9. Epub 2019 Apr 23.

b Center for Communication Science , RTI International , Raleigh , NC , USA.

To determine how individual difference (age, cognition, and hearing) and risk presentation (audio frequency, speed, and organization) variables affect viewing of direct-to-consumer (DTC) prescription drug television ads, participants (N = 1,075) from four age groups across the adult lifespan took an in-person hearing examination, watched a DTC television ad, and responded to survey questions. Results showed that increased age was related to reduced cognition and hearing ability, as well as lower ad comprehension and risk recall. Greater speed and more complex organization of the ad's risk information lowered risk recall and claim recognition. Read More

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http://dx.doi.org/10.1080/10810730.2019.1606364DOI Listing

Quality of life among patients after cystoprostatectomy as the treatment for locally advanced prostate cancer with bladder invasion.

Aging Male 2019 Apr 23:1-7. Epub 2019 Apr 23.

a Department of Urology, Tongji Hospital, Tongji Medical School , Huazhong University of Science and Technology , Wuhan , China.

Purpose: This study aimed to evaluate the changes of patients' quality of life (QoL) after cystoprostatectomy as a treatment for locally advanced prostate cancer (LAPC) with the bladder invasion and to determine risk factors for postoperative poor QoL.

Materials And Methods: Between Jan 2012 and December 2015, 27 patients who received cystoprostatectomy for LAPC with the bladder invasion were retrospectively included. QoL was assessed with the functional assessment of cancer therapy-prostate (FACT-P) questionnaire scores. Read More

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http://dx.doi.org/10.1080/13685538.2019.1604653DOI Listing

Nandrolone decanoate and resistance exercise affect prostate morphology and hormone receptor interface in adult rats with implications for the aging process.

Andrology 2019 Apr 22. Epub 2019 Apr 22.

Department of Anatomy, Institute of Biosciences, University of Estadual Paulista (UNESP), Botucatu, SP, Brazil.

Background: Nandrolone decanoate (ND) is an anabolic-androgenic steroid, and its indiscriminate use leads to subclinical alterations in the hypothalamic-pituitary-gonadal axis and androgen-dependent organs.

Objectives: To evaluate the effects of ND, either alone or in combination with resistance exercise (RE), on the levels of sex hormones, converting enzymes, and steroid receptors and the morphology of the ventral prostate (VP) in adult and aged rats.

Methods: Forty Sprague-Dawley adult and aged rats were divided into four groups each, sedentary and trained with and without ND. Read More

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http://dx.doi.org/10.1111/andr.12626DOI Listing

The association of cancer-related fatigue with all-cause mortality of colorectal and endometrial cancer survivors: Results from the population-based PROFILES registry.

Cancer Med 2019 Apr 22. Epub 2019 Apr 22.

Unit of Cancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Purpose: Cancer-related fatigue (CRF) is one of the most prevalent symptoms experienced by cancer survivors. However, researchers are only beginning to elucidate the risk factors, underlying mechanism(s), and its association with other outcomes. Research on the association between CRF and mortality is limited. Read More

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http://dx.doi.org/10.1002/cam4.2166DOI Listing

Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice.

Aging Cell 2019 Apr 22:e12961. Epub 2019 Apr 22.

Department of Neurology, Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Cav1.2 is the pore-forming subunit of L-type voltage-gated calcium channel (LTCC) that plays an important role in calcium overload and cell death in Alzheimer's disease. LTCC activity can be regulated by estrogen, a sex steroid hormone that is neuroprotective. Read More

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http://dx.doi.org/10.1111/acel.12961DOI Listing

When immediate losses are followed by delayed gains: Additive hyperboloid discounting models.

Psychon Bull Rev 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.

Discounting research has tended to focus on one simple situation, choice between an immediate, smaller gain and a larger, delayed gain, that is assumed by many to capture the essence of self-control. In everyday life, however, most choice situations are more complex, often involving combinations of gains and losses. We examined discounting in situations involving an immediate loss followed by a delayed gain that resulted in either a net gain (Experiment 1) or a net loss (Experiment 2) and compared it with discounting when there was only a delayed gain and no immediate loss. Read More

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http://link.springer.com/10.3758/s13423-019-01599-5
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http://dx.doi.org/10.3758/s13423-019-01599-5DOI Listing

Imaging the effects of age on proactive control in healthy adults.

Brain Imaging Behav 2019 Apr 23. Epub 2019 Apr 23.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06519, USA.

Previous research has reported reduced efficiency in reactive inhibition, along with reduced brain activations, in older adults. The current study investigated age-related behavioral and neural changes in proactive inhibition, and whether age may influence the relationship between proactive and reactive inhibition. One-hundred-and-forty-nine adults (18 to 72 years) underwent fMRI while performing a stop signal task (SST). Read More

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http://dx.doi.org/10.1007/s11682-019-00103-wDOI Listing

Decline of popliteal artery flow-mediated dilation with aging and possible involvement of asymmetric dimethylarginine in healthy men.

J Med Ultrason (2001) 2019 Apr 23. Epub 2019 Apr 23.

Department of Cardiology, Iwate Prefectural Central Hospital, 1-4-1 Ueda, Morioka, 020-0066, Japan.

Purpose: We examined the influences of age and gender on flow-mediated endothelial function and the involvement of the competitive inhibition of L-arginine in endothelial function.

Methods: We measured brachial and popliteal flow-mediated vasodilation (FMD) responses, nitrate/nitrite (NOx) concentrations, and plasma levels of asymmetric dimethylarginine (ADMA) in four healthy, nonsmoking groups: young men (mean 26 ± 2 years, n = 17), middle-aged men (mean 50 ± 3 years, n = 19), young women (mean 27 ± 2 years, n = 16), and middle-aged women (mean 51 ± 2 years, n = 18).

Results: In young men, we found no significant differences between brachial and popliteal artery FMDs (10. Read More

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http://link.springer.com/10.1007/s10396-019-00946-2
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http://dx.doi.org/10.1007/s10396-019-00946-2DOI Listing
April 2019
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Aging with multiple sclerosis: prevalence and profile of cognitive impairment.

Neurol Sci 2019 Apr 23. Epub 2019 Apr 23.

Department NEUROFARBA, Section Neurosciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.

Background: The increase in life expectancy of patients with multiple sclerosis (MS) requires a better knowledge of disease features in the older patients group.

Objective: To describe the prevalence and profile of cognitive impairment (CI) in older patients with MS and perform a comparison with younger patients.

Methods: Patients were consecutively recruited for 6 months. Read More

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http://dx.doi.org/10.1007/s10072-019-03875-7DOI Listing

Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders.

J Neuroimmune Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, M741A Medical Science Building, 1 Hospital Drive, Columbia, MO, 65211, USA.

Despite significant advancements in the field of molecular neurobiology especially neuroinflammation and neurodegeneration, the highly complex molecular mechanisms underlying neurodegenerative diseases remain elusive. As a result, the development of the next generation neurotherapeutics has experienced a considerable lag phase. Recent advancements in the field of genome editing offer a new template for dissecting the precise molecular pathways underlying the complex neurodegenerative disorders. Read More

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http://dx.doi.org/10.1007/s11481-019-09849-yDOI Listing

Super-elderly patient-specific perioperative complications in breast cancer surgery.

Surg Today 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Oncology, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka, 534-0021, Japan.

Purpose: Geriatric surgery poses specific challenges due to patient vulnerability in relation to aging. We analyzed perioperative challenges concerning super-elderly patients with breast cancer.

Methods: Between 2013 and 2018, 908 patients with breast cancer were treated surgically. Read More

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http://link.springer.com/10.1007/s00595-019-01812-x
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http://dx.doi.org/10.1007/s00595-019-01812-xDOI Listing
April 2019
1 Read

Dynamic changes of phenolic compounds during artificial aging of soybean seeds identified by high-performance liquid chromatography coupled with transcript analysis.

Anal Bioanal Chem 2019 Apr 22. Epub 2019 Apr 22.

College of Life Sciences, Nanchang University, Nanchang, 330031, Jiangxi, China.

Phenolic compounds are important bioactive substances in plants, but study of their alteration during soybean seed aging is still limited. In this study, we conducted artificial aging on soybean seeds, detected the dynamic changes of phenolic compound concentrations using high-performance liquid chromatography, and analyzed the gene expression of key enzymes of phenolic metabolism. A detailed method for detection of 19 phenolic compounds during artificial aging of soybean seeds was constructed, and all of these phenols significantly changed in concentration. Read More

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http://dx.doi.org/10.1007/s00216-019-01767-5DOI Listing

General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women.

Alzheimers Dement (N Y) 2019 10;5:118-128. Epub 2019 Apr 10.

Department of Neurology, University of Southern California, Los Angeles, CA, USA.

Introduction: In a geographically diverse sample of women, we asked whether cognitive reserve (CR) is best viewed as a general or cognitive domain-specific construct and whether some cognitive reserve domains but not others exert protective effects on risk of developing mild cognitive impairment (MCI) or dementia.

Methods: Estimates of general and domain-specific CR were derived via variance decomposition in 972 cognitively intact women from the Women's Health Initiative Study of Cognitive Aging and Women's Health Memory Study Magnetic Resonance Imaging. Women were then followed up for 13 years. Read More

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http://dx.doi.org/10.1016/j.trci.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461572PMC

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.

Alzheimers Dement (N Y) 2019 9;5:107-117. Epub 2019 Apr 9.

Molecular & Clinical Sciences Research Institute, St George's University of London and Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23528737193000
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http://dx.doi.org/10.1016/j.trci.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461571PMC
April 2019
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The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.

Alzheimers Dement (Amst) 2019 Dec 12;11:310-326. Epub 2019 Apr 12.

Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies.

Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. Read More

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http://dx.doi.org/10.1016/j.dadm.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465616PMC
December 2019

Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings.

Adv Pharm Bull 2019 Feb 21;9(1):48-55. Epub 2018 Feb 21.

Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.

Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebral ischemia remains unclear. Here we reviewed current understanding of testosterone (TES) neuroprotective activity against ischemic stroke and mechanisms underlying these effects in aging. TES may exert a neuroprotective effect in aging through pathways including inhibition of oxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain and modulation of apoptotic cell death. Read More

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http://dx.doi.org/10.15171/apb.2019.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468219PMC
February 2019

Using Ketamine and Propofol for Procedural Sedation of Adults in the Emergency Department: A Systematic Review and Meta-Analysis.

Adv Pharm Bull 2019 Feb 21;9(1):5-11. Epub 2019 Feb 21.

Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Ketamine-propofol combination (ketofol) is being used to provide a safe and effective procedural sedation (PS) in emergency department (ED) and may theoretically have beneficial effects since using lower doses of each drug may result in a reduction of the adverse events of both agents while maintaining optimal conditions for performing procedures. This systematic review was conducted to evaluate the efficacy, advantages and disadvantages of these two drugs for PS. The PRISMA statement was used for this systematic review. Read More

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https://apb.tbzmed.ac.ir/Abstract/apb-22985
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http://dx.doi.org/10.15171/apb.2019.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468222PMC
February 2019
1 Read

Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients.

J Bone Oncol 2019 Jun 4;16:100237. Epub 2019 Apr 4.

Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine III, TU Dresden Medical Center, Fetscherstraße 74, D-01307 Dresden, Germany.

Background: Semaphorin 4D (Sema4D) is a glycoprotein that inhibits bone formation and has been associated with cancer progression and the occurrence of bone metastases. Recently, Sema4D expression has been linked to estrogen signaling in breast cancer. Endocrine therapies like tamoxifen and aromatase inhibitors (AI) are a standard therapeutic approach in hormone receptor positive breast cancers. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461588PMC

Use of age-period-cohort analysis in cancer epidemiology research.

Curr Epidemiol Rep 2018 Dec 3;5(4):418-431. Epub 2018 Oct 3.

Department of Sociology, Lineberger Cancer Center, and Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Purpose Of Review: Age-period-cohort (APC) models simultaneously estimate the effects of age - biological process of aging; time period - secular trends that occur in all ages simultaneously; and birth cohort - variation among those born around the same year or from one generation to the next. APC models inform understanding of cancer etiology, natural history, and disparities. We reviewed findings from recent studies (published 2008-2018) examining age, period, and cohort effects and summarized trends in age-standardized rates and age-specific rates by birth cohort. Read More

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http://dx.doi.org/10.1007/s40471-018-0174-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474378PMC
December 2018

Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.

Aging Dis 2019 Apr 1;10(2):470-482. Epub 2019 Apr 1.

Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center College of Medicine, College Station, Texas, USA.

The mechanisms that underlie the pathophysiology of aging, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and stroke are not fully understood and have been the focus of intense and constant investigation worldwide. Studies that provide insights on aging and age-related disease mechanisms are critical for advancing novel therapies that promote successful aging and prevent or cure multiple age-related diseases. The April 2019 issue of the journal, "Aging & Disease" published a series of articles that confer fresh insights on numerous age-related conditions and diseases. Read More

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http://dx.doi.org/10.14336/AD.2019.0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457051PMC

Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults.

Aging Dis 2019 Apr 1;10(2):463-469. Epub 2019 Apr 1.

1INSERM, Univ Montpellier, Neuropsychiatry, Epidemiological and Clinical Research, Montpellier, France.

Chronic systemic low-grade inflammation is associated with aging, but little is known on whether age-related inflammation affects brain structure, particularly white matter. The current study tested the hypothesis that in older adults without dementia, higher serum levels of high-sensitivity C-reactive protein (hs-CRP) are associated with reduced corpus callosum (CC) areas. French community-dwelling subjects (ESPRIT study) aged 65 and older (N=101) underwent hs-CRP testing and structural magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.14336/AD.2018.0329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457060PMC

Significance of Complement System in Ischemic Stroke: A Comprehensive Review.

Aging Dis 2019 Apr 1;10(2):429-462. Epub 2019 Apr 1.

1Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

The complement system is an essential part of innate immunity, typically conferring protection via eliminating pathogens and accumulating debris. However, the defensive function of the complement system can exacerbate immune, inflammatory, and degenerative responses in various pathological conditions. Cumulative evidence indicates that the complement system plays a critical role in the pathogenesis of ischemic brain injury, as the depletion of certain complement components or the inhibition of complement activation could reduce ischemic brain injury. Read More

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http://dx.doi.org/10.14336/AD.2019.0119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457046PMC

The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis.

Aging Dis 2019 Apr 1;10(2):419-428. Epub 2019 Apr 1.

1School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.

Aging promotes a range of degenerative pathologies characterized by progressive losses of tissue and/or cellular function. Fibrosis is the hardening, overgrowth and scarring of various tissues characterized by the accumulation of extracellular matrix components. Aging is an important predisposing factor common for fibrotic heart and respiratory disease. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0601
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http://dx.doi.org/10.14336/AD.2018.0601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457057PMC
April 2019
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Efficacy and Safety of the Pneumococcal Conjugate-13 Valent Vaccine in Adults.

Aging Dis 2019 Apr 1;10(2):404-418. Epub 2019 Apr 1.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.

Invasive pneumococcal disease and pneumococcal pneumonia cause substantial morbidity and mortality in the elderly. This review focuses on the immunogenicity, safety, efficacy and effectiveness data on the use of the 13-valent conjugate pneumococcal vaccine (PCV13) in adults. A MEDLINE literature search was performed from January 1946 to December 2017. Read More

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http://dx.doi.org/10.14336/AD.2018.0512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457056PMC

Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer's Disease.

Aging Dis 2019 Apr 1;10(2):383-403. Epub 2019 Apr 1.

1Washington Institute for Health Sciences, Arlington, VA 22203, USA.

Alzheimer's disease (AD) is a complex, multifactorial disease involving many pathological mechanisms. Nonetheless, single pathogenic mutations in amyloid precursor protein (APP) or presenilin 1 or 2 can cause AD with almost all of the clinical and neuropathological features, and therefore, we believe an important mechanism of pathogenesis in AD could be revealed from examining pathogenic APP missense mutations. A comprehensive review of the literature, including clinical, neuropathological, cellular and animal model data, was conducted through PubMed and the databases of Alzforum mutations, HGMD, UniProt, and AD&FTDMDB. Read More

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http://dx.doi.org/10.14336/AD.2018.0425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457050PMC

Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept.

Aging Dis 2019 Apr 1;10(2):367-382. Epub 2019 Apr 1.

8Department of Physiology, The University of Texas Health Science Center at San Antonio, TX 78229, USA.

Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate the aging process and age-related chronic diseases. Currently, there are two major hypotheses related to the involvement of chronic inflammation in the aging process: molecular inflammation of aging and inflammaging. However, neither of these hypotheses satisfactorily addresses age-related chronic inflammation, considering the recent advances that have been made in inflammation research. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0324
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http://dx.doi.org/10.14336/AD.2018.0324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457053PMC

MicroRNAs or Long Noncoding RNAs in Diagnosis and Prognosis of Coronary Artery Disease.

Aging Dis 2019 Apr 1;10(2):353-366. Epub 2019 Apr 1.

Institute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, China.

Coronary artery disease (CAD) is the result of atherosclerotic plaque development in the wall of the coronary arteries. The underlying mechanism involves atherosclerosis of the arteries of the heart which is a relatively complex process comprising several steps. In CAD, atherosclerosis induces functional and structural changes. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0617
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http://dx.doi.org/10.14336/AD.2018.0617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457061PMC
April 2019
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MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma.

Aging Dis 2019 Apr 1;10(2):329-352. Epub 2019 Apr 1.

Center for Basic and Translational Stroke Research, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.

Aging is a complex and integrated gradual deterioration of cellular activities in specific organs of the body, which is associated with increased mortality. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, neurovascular disorders, and neurodegenerative diseases. There are nine tentative hallmarks of aging. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0409
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http://dx.doi.org/10.14336/AD.2018.0409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457055PMC

Deficiency of Yes-Associated Protein Induces Cataract in Mice.

Aging Dis 2019 Apr 1;10(2):293-306. Epub 2019 Apr 1.

2The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.

Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract. Histologically, Yap deficient lens show fewer epithelial cells, retention of nuclei and accumulation of morgagnian globules in the transitional zone and the posterior area. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0910
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http://dx.doi.org/10.14336/AD.2018.0910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457047PMC
April 2019
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Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis.

Aging Dis 2019 Apr 1;10(2):278-292. Epub 2019 Apr 1.

2Neurology Department, ALS Unit, CIBERER U-723, Health Research Institute, October 12th Hospital "IIS I+12", Madrid, Spain.

The identification of more reliable diagnostic or prognostic biomarkers in age-related neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), is urgently needed. The objective in this study was to identify more reliable prognostic biomarkers of ALS mirroring neurodegeneration that could be of help in clinical trials. A total of 268 participants from three cohorts were included in this study. Read More

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http://dx.doi.org/10.14336/AD.2018.0917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457048PMC

Habitual Meat Consumption and Changes in Sleep Duration and Quality in Older Adults.

Aging Dis 2019 Apr 1;10(2):267-277. Epub 2019 Apr 1.

2Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, Spain /IdiPAZ, CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Dietary proteins are sources of some amino acid precursors of two neurotransmitters relevant for biological rhythms, serotonin and melatonin, which are involved in sleep and alertness. Meat is the main source of proteins in many countries. Furthermore, meat consumption is of special interest because it provides high-quality protein as well as saturated and fatty acids. Read More

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http://dx.doi.org/10.14336/AD.2018.0503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457059PMC

Intensive Lipid-Lowering Therapy Ameliorates Asymptomatic Intracranial Atherosclerosis.

Aging Dis 2019 Apr 1;10(2):258-266. Epub 2019 Apr 1.

1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Statins have proven to exert protective effects in patients with symptomatic intracranial atherosclerotic stenosis (SICAS). It is unclear whether intensive lipid-lowering therapy (ILLT) can ameliorate atherosclerosis in asymptomatic ICAS (AICAS). A single-center, prospective cohort study was performed in 71 AICAS patients with lipid-lowering therapy. Read More

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http://dx.doi.org/10.14336/AD.2018.0526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457052PMC