510,072 results match your criteria Aging & Mental Health[Journal]


Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion.

J Immunother Cancer 2022 May;10(5)

Department of Core Laboratory of Translational Research, Biomedical Convergence Research Center, Chungnam National University Hospital, Daejeon, South Korea

Background: Mitochondria are involved in cancer energy metabolism, although the mechanisms underlying the involvement of mitoribosomal dysfunction in hepatocellular carcinoma (HCC) remain poorly understood. Here, we investigated the effects of mitoribosomal impairment-mediated alterations on the immunometabolic characteristics of liver cancer.

Methods: We used a mouse model of HCC, liver tissues from patients with HCC, and datasets from The Cancer Genome Atlas (TCGA) to elucidate the relationship between mitoribosomal proteins (MRPs) and HCC. Read More

View Article and Full-Text PDF

Identification of combined biomarkers for predicting the risk of osteoporosis using machine learning.

Aging (Albany NY) 2022 May 17;14(undefined). Epub 2022 May 17.

BK21 PLUS Project, Department of Dental Education, Yonsei University College of Dentistry, Seoul, Korea.

Osteoporosis is a severe chronic skeletal disorder that affects older individuals, especially postmenopausal women. However, molecular biomarkers for predicting the risk of osteoporosis are not well characterized. The aim of this study was to identify combined biomarkers for predicting the risk of osteoporosis using machine learning methods. Read More

View Article and Full-Text PDF

Transcriptional ITPR3 as potential targets and biomarkers for human pancreatic cancer.

Aging (Albany NY) 2022 May 17;14(undefined). Epub 2022 May 17.

Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.

Inositol 1,4,5-Triphosphate Receptor Family (ITPRs) are necessary intracellular Ca2+-release channel encoders and participate in mammalian cell physiological and pathological processes. Previous studies have suggested that ITPRs participate in tumorigenesis of multiple cancers. Nevertheless, the diverse expression profiles and prognostic significance of three ITPRs in pancreatic cancer have yet to be uncovered. Read More

View Article and Full-Text PDF

Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.

Neurobiol Dis 2022 May 14:105769. Epub 2022 May 14.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-3707, USA. Electronic address:

Coding mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene, which are associated with dominantly inherited Parkinson's disease (PD), lead to an increased activity of the encoded LRRK2 protein kinase. As such, kinase inhibitors are being considered as therapeutic agents for PD. It is therefore of interest to understand the mechanism(s) by which LRRK2 is activated during cellular signaling. Read More

View Article and Full-Text PDF

Change in patients' perceived cognition following chimeric antigen receptor T-cell therapy for lymphoma.

Transplant Cell Ther 2022 May 14. Epub 2022 May 14.

Department of Health Outcomes and Behavior, Moffitt Cancer Center. Electronic address:

Background: Chimeric antigen receptor (CAR) T-cell therapy can lead to durable responses in patients with relapsed/refractory hematologic malignancies. Immune effector cell-associated neurotoxicity syndrome (ICANS) and cytokine release syndrome (CRS) are common and may place patients at risk for longer-term cognitive impairment.

Objective: This study examined changes in cognition in the first year after CD19-directed CAR-T-cell therapy for lymphoma, as well as CAR T-cell therapy-specific risk-factors (e. Read More

View Article and Full-Text PDF

Aging of Glucose Profiles in an Adult Population without Diabetes.

Diabetes Res Clin Pract 2022 May 14:109929. Epub 2022 May 14.

Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain; Research Methods (RESMET). Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain; University Hospital of Santiago de Compostela, Department of Clinical Epidemiology.

Aims: This study aimed to determine the effect of aging on glucose profiles in a population without diabetes.

Methods: We investigated the evolution of glucose profiles in an adult population without diabetes using continuous glucose monitoring (CGM) in two periods separated by 5 years. Anthropometrics, laboratory tests (HbA1c, fasting blood glucose) and CGM data (mean glycemia level, coefficient of variation, time in range) were measured in both periods to study the change in values over time. Read More

View Article and Full-Text PDF

Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation.

Cell Metab 2022 May 10. Epub 2022 May 10.

Department of Biology, University of Rochester, Rochester, NY 14627, USA. Electronic address:

Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with expression levels negatively or positively correlated with a species' maximum lifespan (Neg- or Pos-MLS genes). Read More

View Article and Full-Text PDF

Autosomal dominant and sporadic late onset Alzheimer disease share a common in vivo pathophysiology.

Brain 2022 May 17. Epub 2022 May 17.

Department of Radiology, Washington University School of Medicine; St. Louis, MO, USA.

The extent to which the pathophysiology of autosomal dominant Alzheimer disease corresponds to the pathophysiology of "sporadic" late onset Alzheimer disease is unknown, thus limiting the extrapolation of study findings and clinical trial results in autosomal dominant Alzheimer disease to late onset Alzheimer disease. We compared brain magnetic resonance imaging and amyloid positron emission tomography data, as well as cerebrospinal fluid concentrations of amyloid-beta-42, amyloid-beta-40, tau, and tau phosphorylated at position 181, in 292 carriers of pathogenic variants for Alzheimer disease from the Dominantly Inherited Alzheimer Network with corresponding data from 559 participants from the Alzheimer's Disease Neuroimaging Initiative. Imaging data and cerebrospinal fluid samples were reprocessed as appropriate to guarantee uniform pipelines and assays. Read More

View Article and Full-Text PDF

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss.

Am J Hum Genet 2022 May 12. Epub 2022 May 12.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.

Hearing loss is one of the top contributors to years lived with disability and is a risk factor for dementia. Molecular evidence on the cellular origins of hearing loss in humans is growing. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported hearing impairment on 723,266 individuals and identified 48 significant loci, 10 of which are novel. Read More

View Article and Full-Text PDF

Age-dependent associations of body mass index with myocardial infarction, heart failure, and mortality in over 9 million Koreans.

Eur J Prev Cardiol 2022 May 17. Epub 2022 May 17.

Division of Cardiology, Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul National University College of Medicine, Korea.

Background: While obesity is a well-known cardiovascular risk factor, little is known whether age has a modifying effect.

Aim: To determine the age-dependent associations of BMI with cardiovascular outcomes.

Methods: A population-based cohort of 9,278,433 Koreans without prior cardiovascular disease were followed up for the incidence of myocardial infarction (MI), heart failure (HF), and all-cause death. Read More

View Article and Full-Text PDF

Depressive Symptoms, Subjective Cognitive Decline, and Subjective Sleep Quality Are Associated with Slips and Falls: Data from the Community Health Survey in Korean Adults.

Gerontology 2022 27;68(5):518-528. Epub 2021 Dec 27.

Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea.

Background: Identifying the risk factors for falls among the elderly population is arguably one of the most imperative public health issues in the current aging society.

Objectives: This study aimed to determine the associations between depressive symptoms, subjective cognitive decline (SCD), and poor subjective sleep quality and the risk of slips/falls in a Korean older population.

Methods: This cross-sectional study involved 228,340 elderly individuals living in Korea. Read More

View Article and Full-Text PDF
December 2021

Dietary inflammatory index is associated with lung function in healthy older adults.

Nutrition 2022 Mar 11;99-100:111653. Epub 2022 Mar 11.

Department of Medicine (DIMED), Geriatrics Division, University of Padua, Italy.

Objectives: Aging is associated with low-grade chronic inflammation contributing to a decline in lung performance. The Dietary Inflammatory Index (DII) has been introduced to evaluate the inflammatory potential of different diets, which may further affect individuals' respiratory function. This study investigates the association between DII and lung performance in older adults. Read More

View Article and Full-Text PDF

Protein interaction network analysis reveals genetic enrichment of immune system genes in frontotemporal dementia.

Neurobiol Aging 2022 Apr 9;116:67-79. Epub 2022 Apr 9.

Neurodegenerative Brain Diseases, VIB Center for Molecular Neurology, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address:

Interactors of protein products of known genes for frontotemporal dementia (FTD) are likely to be involved in the molecular pathways towards disease. We therefore applied protein interaction network (PIN) analysis to prioritize candidate genes for rare variant association analysis. We created an FTD-PIN starting from known FTD genes downloading their physical interactors and performed functional enrichment analyses. Read More

View Article and Full-Text PDF

Intermediate alleles of HTT: A new pathway in longevity.

J Neurol Sci 2022 May 4;438:120274. Epub 2022 May 4.

Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy. Electronic address:

Centenarians are the best example of successful aging, reaching extreme longevity escaping age-related diseases. Genome sequencing studies provided evidence for genetic factors linked to heathy long life, including genes related to age-dependent diseases. HTT (Huntingtin) gene is linked to Huntington's Disease, but also associated to longevity in capuchins and mice. Read More

View Article and Full-Text PDF

Prediction Model of Photodegradation for PBAT/PLA Mulch Films: Strategy to Fast Evaluate Service Life.

Environ Sci Technol 2022 May 17. Epub 2022 May 17.

College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018, China.

Eco-friendly biodegradable PBAT/PLA mulch films are attracting increasing interest in sustainable agricultural production. However, currently, little is known about the service life for the PBAT/PLA mulch films. Herein, PBAT/PLA mulch films are subjected to indoor UV-accelerated degradation (UAD) experiments and field cultivation environment degradation (CED) experiments to systematically investigate the relationship between UAD and CED processes. Read More

View Article and Full-Text PDF

DNA methylation clocks for dogs and humans.

Proc Natl Acad Sci U S A 2022 May 17;119(21):e2120887119. Epub 2022 May 17.

National Human Genome Research Institute, NIH, Bethesda, MD 20892.

SignificanceEpigenetic estimators of age (known as clocks) allow one to identify interventions that slow or reverse aging. Previous epigenetic clocks only applied to one species at a time. Here, we describe epigenetic clocks that apply to both dogs and humans. Read More

View Article and Full-Text PDF

Sperm DNA integrity is critically impacted by male age but does not influence outcomes of artificial insemination by husband in the Chinese infertile couples.

Aging (Albany NY) 2022 May 17;14(undefined). Epub 2022 May 17.

Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.

The sperm chromatin structure assay (SCSA) is crucial for assessing male fertility. However, the predictive value of the SCSA parameters, including the DNA fragment indices (DFI) and the percentages of high DNA stainability (HDS), for outcomes of artificial insemination by husband (AIH) remains controversial. This study aims to evaluate the correlations between SCSA parameters and male aging as well as other routine semen parameters, and explore their prognostic powers on AIH outcomes of the Chinese infertile couples. Read More

View Article and Full-Text PDF

Role of Neighborhood Physical Disorder and Social Cohesion on Racial and Ethnic Disparities in Dementia Risk.

Authors:
Roger Wong Yi Wang

J Aging Health 2022 May 17:8982643221101352. Epub 2022 May 17.

School of Social Work, University of Iowa, Iowa City, IA, USA.

To analyze how neighborhood physical disorder and social cohesion are associated with racial and ethnic disparities in dementia risk. Nine years of data (2011-2019) were retrieved from the National Health and Aging Trends Study, a nationally representative U.S. Read More

View Article and Full-Text PDF

Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes.

Mol Biol Evol 2022 May;39(5)

Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.

Mutational processes in tumors create distinctive patterns of mutations, composed of neutral "passenger" mutations and oncogenic drivers that have quantifiable effects on the proliferation and survival of cancer cell lineages. Increases in proliferation and survival are mediated by natural selection, which can be quantified by comparing the frequency at which we detect substitutions to the frequency at which we expect to detect substitutions assuming neutrality. Most of the variants detectable with whole-exome sequencing in tumors are neutral or nearly neutral in effect, and thus the processes generating the majority of mutations may not be the primary sources of the tumorigenic mutations. Read More

View Article and Full-Text PDF

DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks.

Nucleic Acids Res 2022 May 17. Epub 2022 May 17.

Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Non-homologous end joining (NHEJ) is the major pathway that mediates the repair of DNA double-strand breaks (DSBs) generated by ionizing radiation (IR). Previously, the DNA helicase RECQL4 was implicated in promoting NHEJ, but its role in the pathway remains unresolved. In this study, we report that RECQL4 stabilizes the NHEJ machinery at DSBs to promote repair. Read More

View Article and Full-Text PDF

Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence.

Aging (Albany NY) 2022 May 16;14(undefined). Epub 2022 May 16.

Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Senescence occurs in response to a number of damaging stimuli to limit oncogenic transformation and cancer development. As no single, universal senescence marker has been discovered, the confident classification of senescence induction requires the parallel assessment of a series of hallmarks. Therefore, there is a growing need for "first-pass" tools of senescence identification to streamline experimental workflows and complement conventional markers. Read More

View Article and Full-Text PDF

Aging, cardiorespiratory fitness and sympathetic transduction.

Aging (Albany NY) 2022 May 16;undefined(undefined). Epub 2022 May 16.

Division of Kinesiology, School of Health and Human Performance, Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.

View Article and Full-Text PDF

Intra-tumoral angiogenesis correlates with immune features and prognosis in glioma.

Aging (Albany NY) 2022 May 17;14(undefined). Epub 2022 May 17.

Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.

Gliomas are the most common malignant tumor in the brain. As with other tumors, the progression of glioma depends on intra-tumoral angiogenesis. However, the effect of angiogenesis on gliomas is still not fully understood. Read More

View Article and Full-Text PDF

A Single Dose of BNT162b2 mRNA Vaccine Induces Airway Immunity in SARS-CoV-2 Naive and recovered COVID-19 subjects.

Clin Infect Dis 2022 May 17. Epub 2022 May 17.

Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Department of Pulmonary Medicine and Thoracic Oncology, FHU OncoAge, Nice, France.

Background: Mucosal antibodies can prevent virus entry and replication in mucosal epithelial cells and hence virus shedding. Parenteral booster injection of a vaccine against a mucosal pathogen promotes stronger mucosal immune responses following prior mucosal infection compared to injections of a parenteral vaccine in a mucosally naive subject. We investigated whether this was also the case for the BNT162b2 COVID-19 mRNA vaccine. Read More

View Article and Full-Text PDF

Age- and Episodic Memory-related Differences in Task-based Functional Connectivity in Women and Men.

J Cogn Neurosci 2022 May 10:1-21. Epub 2022 May 10.

McGill University, Montréal, Quebéc, Canada.

Aging is associated with episodic memory decline and changes in functional brain connectivity. Understanding whether and how biological sex influences age- and memory performance-related functional connectivity has important theoretical implications for the cognitive neuroscience of memory and aging. Here, we scanned 161 healthy adults between 19 and 76 years of age in an event-related fMRI study of face-location spatial context memory. Read More

View Article and Full-Text PDF

Circulating free testosterone and risk of aggressive prostate cancer: prospective and Mendelian randomization analyses in international consortia.

Int J Cancer 2022 May 17. Epub 2022 May 17.

Department of Public Health and Health Policy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, the association of genetically predicted testosterone with aggressive disease is not known. We investigated the associations of calculated free and measured total testosterone and sex hormone-binding globulin (SHBG) with aggressive, overall and early-onset prostate cancer. Read More

View Article and Full-Text PDF

An Open, Prospective Cohort Study of VV116 in Chinese Participants Infected with SARS-CoV-2 Omicron Variants.

Emerg Microbes Infect 2022 May 17:1-22. Epub 2022 May 17.

Department of Respiratory Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Omicron variant of SARS-CoV-2 has become the predominant variant worldwide. VV116 is an oral drug with robust anti-SARS-CoV-2 efficacy in preclinical studies. We conducted an open, prospective cohort study to evaluate its safety and effectiveness in Chinese participants infected with SARS-CoV-2 omicron variant from March 8th, 2022 to Marth 24th, 2022. Read More

View Article and Full-Text PDF

Knowledge, Attitudes, and Cultural Beliefs about Healthy Aging and Alzheimer's Disease among Older Chinese Americans in New York City.

J Cross Cult Gerontol 2022 May 17. Epub 2022 May 17.

Center for the Study of Asian American Health, Department of Population Health, NYU Langone Health, New York, NY, 10016, USA.

Alzheimer's Disease (AD) and Related Dementias (ADRD) are a growing concern across the globe. Unfortunately, racial/ethnic minorities in the United States (U.S. Read More

View Article and Full-Text PDF

Multidimensional frailty and quality of life: data from the English Longitudinal Study of Ageing.

Qual Life Res 2022 May 17. Epub 2022 May 17.

Department of Geriatric Care, Orthogeriatrics and Rehabilitation, E.O. Ospedali Galliera, Genoa, Italy.

Purpose: Frailty has been found to be associated with poor quality of life (QoL) in older people, but data available are limited to cross-sectional studies. We therefore aimed to assess the association between multidimensional frailty, determined by Multidimensional Prognostic Index (MPI), with mortality and good QoL expectancy (GQoLE) in a large representative sample of older adults, over 10 years of follow-up.

Methods: In the English Longitudinal Study of Ageing, using the data from 2004-2005 and 2014-2015, MPI was calculated using a weighted score of domains of comprehensive geriatric assessment, i. Read More

View Article and Full-Text PDF

Aberrant topological organization and age-related differences in the human connectome in subjective cognitive decline by using regional morphology from magnetic resonance imaging.

Brain Struct Funct 2022 May 17. Epub 2022 May 17.

Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science & Medical Engineering, Beihang University, Beijing, China.

Subjective cognitive decline (SCD) is characterized by self-experienced deficits in cognitive capacity with normal performance in objective cognitive tests. Previous structural covariance studies showed specific insights into understanding the structural alterations of the brain in neurodegenerative diseases. Moreover, in subjects with neurodegenerative diseases, accelerated brain degeneration with aging was shown. Read More

View Article and Full-Text PDF