2,603 results match your criteria Aging[Journal]
Aging (Albany NY) 2018 Dec 5. Epub 2018 Dec 5.
Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge, UK.
Aging (Albany NY) 2018 Dec 5. Epub 2018 Dec 5.
KU Leuven, Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, Leuven 3001, Belgium.
Aging (Albany NY) 2018 Dec 4. Epub 2018 Dec 4.
Department of Urology, Shanghai Changzheng Hospital, Shanghai 200003, China.
Long non-coding RNAs (lncRNAs) have been found essential for tumorigenesis of prostate cancer (PC), but its role in the regulation of castration-resistant prostate cancer (CRPC) is poorly identified. Here, we showed that a lncRNA, Breast-Cancer Anti-Estrogen Resistance 4 (BCAR4), which plays a pivotal role in the tamoxifen-resistance of breast cancer, was significantly upregulated in CRPC, but not in castration-sensitive prostate cancer (CSPC), compared to normal prostate tissue. High BCAR4 levels in CRPC were correlated with poor patients' overall survival. Read More
Aging (Albany NY) 2018 Dec 4. Epub 2018 Dec 4.
Department of General Surgery, The First Affiliated Hospital of Soochow University, Institutes for Translational Medicine, Soochow University, Suzhou, China.
Aged liver is usually impaired in response to hepatic injury. Tissue-specific stem cells participate in the repair of tissue injury. However, how oval cells (OCs) respond to injury and how the process is regulated by tissue microenvironment in aged mice have not been fully understood. Read More
Aging (Albany NY) 2018 Nov;10(11):3627
Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Aging (Albany NY) 2018 Nov;10(11):3626
State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Aging (Albany NY) 2018 Nov;10(11):3371-3381
Surgical Center, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling 317500, Zhejiang Province, China.
Background: Growing evidence shows that long noncoding RNAs (lncRNAs) play a crucial role in cancer progression. However, whether lncRNA CDKN2BAS is involved in human hepatocellular carcinoma (HCC) metastasis remains unclear.
Methods: Human lncRNA microarray analysis was performed to detect differential expression levels of lncRNAs in metastatic HCC tissues. Read More
Aging (Albany NY) 2018 Nov;10(11):3558-3573
Department of Experimental Medicine and TOR, University of Rome "Tor Vergata", Rome, Italy.
p53, with its family members p63 and p73, have been shown to promote myoblast differentiation by regulation of the function of the retinoblastoma protein and by direct activation of p21 and p57, promoting cell cycle exit. In previous studies, we have demonstrated that the TAp63γ isoform is the only member of the p53 family that accumulates during myoblasts differentiation, and that its silencing led to delay in myotube fusion. To better dissect the role of TAp63γ in myoblast physiology, we have generated both sh-p63 and Tet-On inducible TAp63γ clones. Read More
Aging (Albany NY) 2018 Nov 28. Epub 2018 Nov 28.
Division of Cardiology, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm 17176, Sweden.
Aging (Albany NY) 2018 Nov;10(11):3438-3449
Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, 300052, China.
In China, >70% of stroke deaths occur in people aged ≥65 years. However, trends in the stroke incidence among elderly people are unclear. We aimed to determine trends in the stroke incidence among elderly people in rural China. Read More
Aging (Albany NY) 2018 Nov;10(11):3353-3370
Department of Oncology, The First Clinic College of Hubei University of Chinese Medicine, Wuhan 430065, Hubei, China.
To investigate possible mechanism of abnormal methylation of long non-coding RNA (lncRNA) on endometrial carcinoma (EC) progression, we detected the genome methylation profiling of endometrial carcinoma by bioinformatic analysis. Accordingly, gene was chosen for the further research. We also found that was the target gene of and miRNA, hsa-miR-196a-5p, might form a connection between and . Read More
Aging (Albany NY) 2018 Nov;10(11):3528-3540
Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, China.
Familial longevity is characterized by beneficial metabolic phenotype in lipid metabolism and genetic variation. Although effects of lipid metabolism and the genetic basis for human longevity remain largely unclear, the contribution of high-density lipoprotein cholesterol (HDL-C) and ε2 allele has been repeatedly demonstrated. This study was designed to determine whether ApoE isoforms and HDL-C levels marked the familial longevity status in an offspring cohort with the age range of 20-89 years old and subsequently to explore the correlation between these two markers and the aging. Read More
Aging (Albany NY) 2018 Nov 27. Epub 2018 Nov 27.
Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands.
Aging (Albany NY) 2018 Nov;10(11):3574-3589
Institute of Cytology, Russian Academy of Sciences, St-Petersburg 194064, Russia.
Autophagy is conservative catabolic process that degrades organelles, in particular, mitochondria, and misfolded proteins within the lysosomes, thus maintaining cellular viability. Despite the close relationship between mitochondrial dysfunction and cellular senescence, it is unclear how mitochondria damage can induce autophagy in senescent cells. We show that MEK/ERK suppression induces mitochondria damage followed by apoptosis of senescent Ras-expressing cells. Read More
Aging (Albany NY) 2018 Nov;10(11):3474-3485
Key Laboratory, Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University, Qingdao, China.
The corneal endothelium (CE) dysfunction impairs optical transparency and leads to corneal allograft failure. Morphologically, CE cells are characterized by premature senescence at the late stage of corneal graft. However, the detailed molecular mechanisms are largely unknown. Read More
Aging (Albany NY) 2018 Nov;10(11):3541-3557
CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institute for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Age-associated DNA methylation changes have been widely reported across many different tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a surprisingly high degree of accuracy appear to do so independently of tissue and cell-type, suggesting that a component of epigenetic drift is cell-type independent. However, the relative amount of age-associated DNAm changes that are specific to a cell or tissue type versus the amount that occurs independently of cell or tissue type is unclear and a matter of debate, with a recent study concluding that most epigenetic drift is tissue-specific. Read More
Aging (Albany NY) 2018 Nov;10(11):3450-3473
Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Chromobox (CBX) proteins are important components of epigenetic regulation complexes known to play key roles in hepatocellular carcinoma (HCC). Little is known about the function of distinct CBXs in HCC. To address this issue, the study investigated the roles of CBXs in the prognosis of HCC using ONCOMINE, UALCAN, Human Protein Atlas, Kaplan-Meier Plotter, databases. Read More
Aging (Albany NY) 2018 Nov;10(11):3507-3527
Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, China.
Amyotrophic lateral sclerosis (ALS) is an adult disorder of neurodegeneration that manifests as the destruction of upper and lower motor neurons. Beta-N-methylamino-L-alanine (L-BMAA), an amino acid not present in proteins, was found to cause intraneuronal protein misfolding and to induce ALS/Parkinsonism dementia complex (PDC), which presents symptoms analogous to those of Alzheimer's-like dementia and Parkinsonism. L-serine suppresses the erroneous incorporation of L-BMAA into proteins in the human nervous system. Read More
Aging (Albany NY) 2018 Nov 26. Epub 2018 Nov 26.
Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig D-04103, Germany.
Aging (Albany NY) 2018 Nov 26. Epub 2018 Nov 26.
Aalborg University Hospital, Department of Cardiology, Aalborg, Denmark.
Aging (Albany NY) 2018 Nov;10(11):3421-3437
General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu, China.
MicroRNA-150-5p (miR-150-5p) has been implicated in tumor initiation and progression in a variety of cancers. However, its roles in colorectal cancer (CRC) remain largely unknown. In our study, a decreased miR-150-5p expression in CRC tissues was found to be associated with poor overall survival. Read More
Aging (Albany NY) 2018 Nov;10(11):3486-3506
College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University, Qingdao 266109, China.
Zearalenone (ZEA) is a well-known exogenous endocrine disruptor and can lead to severe negative effects on the human and animal reproductive process. Using a follicle culture model, we have previously shown that ZEA exposure significantly affected the follicular development and antrum formation but the underlying mechanisms are not well known. Therefore, in this study, we explored the metabolomic changes of granulosa cell (GC) culture media with or without ZEA exposure. Read More
Aging (Albany NY) 2018 Nov;10(11):3397-3420
Hans Berger Department of Neurology, Jena University Hospital, Jena, Thuringia 07747, Germany.
Replication-based telomere shortening during lifetime is species- and tissue-specific, however, its impact on healthy aging is unclear. In particular, the contribution of telomere truncation to the aging process of the CNS, where replicative senescence alone fails to explain organ aging due to low to absent mitotic activity of intrinsic populations, is undefined. Here, we assessed changes in relative telomere length in non-replicative and replicative neural brain populations and telomerase activity as a function of aging in C57BL/6 mice. Read More
Aging (Albany NY) 2018 Nov;10(11):3382-3396
MRC/ARUK Centre for Musculoskeletal Ageing Research, NIHR Nottingham BRC, University of Nottingham, Nottingham, UK.
Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden. , a model organism for investigating the mechanisms of ageing, also displays sarcopenia, but the underlying mechanism(s) remain elusive. Here, we use natural scaling of lifespan in response to temperature to examine the relationship between mitochondrial content, mitochondrial function, and sarcopenia. Read More
Aging (Albany NY) 2018 Nov;10(11):3327-3352
Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Preservation of mitochondrial function, which is dependent on mitochondrial homeostasis (biogenesis, dynamics, disposal/recycling), is critical for maintenance of skeletal muscle function. Skeletal muscle performance declines upon aging (sarcopenia) and is accompanied by decreased mitochondrial function in fast-glycolytic muscles. Oxidative metabolism promotes mitochondrial homeostasis, so we investigated whether mitochondrial function is preserved in oxidative muscles. Read More
Aging (Albany NY) 2018 Nov;10(11):3067-3078
Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Is aging a disease? It does not matter because aging is already treated using a combination of several clinically-available drugs, including rapamycin. Whether aging is a disease depends on arbitrary definitions of both disease and aging. For treatment purposes, aging is a deadly disease (or more generally, pre-disease), despite being a normal continuation of normal organismal growth. Read More
Aging (Albany NY) 2018 Nov;10(11):3308-3326
Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome 00133, Italy.
The transcription factor p53 is a key player in the tumour suppressive DNA damage response and a growing number of target genes involved in these pathways has been identified. p53 has been shown to be implicated in controlling cell motility and its mutant form enhances metastasis by loss of cell directionality, but the p53 role in this context has not yet being investigated. Here, we report that ZNF185, an actin cytoskeleton-associated protein from LIM-family of Zn-finger proteins, is induced following DNA-damage. Read More
Aging (Albany NY) 2018 Nov;10(11):3173-3184
Department of Clinical and Molecular Sciences-Histology, Università Politecnica delle Marche, Ancona 60020, Italy.
Regenerative medicine approaches based on mesenchymal stem cells (MSCs) are being investigated to treat several aging-associated diseases, including age-related macular degeneration (AMD). Loss of retinal pigment epithelium (RPE) cells occurs early in AMD, and their transplant has the potential to slow disease progression.The human RPE contains a subpopulation of cells - adult RPE stem cells (RPESCs) - that are capable of self-renewal and of differentiating into RPE cells . Read More
Aging (Albany NY) 2018 Nov;10(11):3089-3103
Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China.
High glucose levels negatively affect immune response. However, the underlying mechanisms are not well understood. Upon infection, the round worm induces multiple gene transcription programs, including the Nrf2/SKN-1-mediated detoxification program, to activate the innate immunity. Read More
Aging (Albany NY) 2018 Nov 15. Epub 2018 Nov 15.
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Aging (Albany NY) 2018 Nov;10(11):3294-3307
Translational Medicine, University of Salford, Greater Manchester, United Kingdom.
Here, we employed a "senolytic" assay system as a screening tool, with the goal of identifying and repurposing FDA-approved antibiotics, for the targeting of the senescent cell population. Briefly, we used two established human fibroblast cell lines (MRC-5 and/or BJ) as model systems to induce senescence, via chronic treatment with a DNA-damaging agent, namely BrdU (at a concentration of 100 μM for 8 days). Cell viability was then monitored by using the SRB assay, to measure protein content. Read More
Aging (Albany NY) 2018 Nov;10(11):3058-3060
Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Aging (Albany NY) 2018 Nov 14. Epub 2018 Nov 14.
Hirosaki University Graduate School of Medicine, Department of Neuropathology, Institute of Brain Science, Hirosaki, Japan.
Aging (Albany NY) 2018 Nov;10(11):3229-3248
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Although few drugs are available today for the management of Alzheimer's disease (AD) and many plants and their extracts are extensively employed in animals' studies and AD patients, yet no drug or plant extract is able to reverse AD symptoms adequately. In the present study, (TG), a naturally occurring plant known for its strong antioxidative, anti-inflammatory and anti-amyloidogenic properties, was evaluated on homocysteine (Hcy) induced AD-like pathology and cognitive impairments in rats. We found that TG attenuated Hcy-induced oxidative stress and memory deficits. Read More
Aging (Albany NY) 2018 Nov;10(11):3079-3088
Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Read More
Aging (Albany NY) 2018 Nov;10(11):3063-3064
Instituto de Investigación Médica "Mercedes y Martín Ferreyra", INIMEC-CONICET- Universidad Nacional de Córdoba, Córdoba, Argentina.
Aging (Albany NY) 2018 Nov;10(11):3283-3293
Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.
Ongoing research suggests that mitochondrial dysfunction is a common hallmark in neurodegenerative diseases, pointing to mitochondrial uncoupling process as a critical player. We recently reported that rs9472817-C/G, an intronic variant of neuronal mitochondrial uncoupling protein-4 () gene affects the risk of late onset Alzheimer's disease (LOAD), and that the variant's effect is strongly dependent on -ε4 status. Here, we extended our analysis to a cohort of 751 subjects including late-onset familial and sporadic cases of frontotemporal dementia (FTD; 213), Parkinson disease (PD;96), and 442 healthy controls. Read More
Aging (Albany NY) 2018 Nov;10(11):3065-3066
Medway School of Pharmacy, University of Kent, Chatham, UK.
Aging (Albany NY) 2018 Nov 12. Epub 2018 Nov 12.
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Aging (Albany NY) 2018 Nov 12. Epub 2018 Nov 12.
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, Newark, NJ 07102, USA.
Aging (Albany NY) 2018 Nov;10(11):3610-3625
Section of Oncology and Immunology, Department of Surgery, Oncology and Gastroenterology, Unit of viral Oncology and AIDS Reference Center, University of Padova, Padova, Italy.
Background: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children.
Methods: A narrative review was performed searching studies on PubMed published in English language in 2004-2017, using appropriate key words, including "aging", "children", "HIV", "AIDS", "immunosenescence", "pathogenesis", "clinical conditions". Read More
Aging (Albany NY) 2018 Nov;10(11):3249-3259
Beiersdorf AG, Hamburg, Germany.
Aging biomarkers are the qualitative and quantitative indicators of the aging processes of the human body. Estimation of biological age is important for assessing the physiological state of an organism. The advent of machine learning lead to the development of the many age predictors commonly referred to as the "aging clocks" varying in biological relevance, ease of use, cost, actionability, interpretability, and applications. Read More
Aging (Albany NY) 2018 Nov;10(11):3061-3062
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Aging (Albany NY) 2018 Nov;10(11):3210-3228
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
The discrepancy of DNA methylation age (DNAmAge) with chronological age (termed as age acceleration, AA) has been identified to be associated with many aging-related health outcomes including hypertension. Since taking antihypertensive medication (AHM) could prevent aging-related diseases caused by hypertension, we hypothesized that using AHM could also reduce the AA. We examined this hypothesis among 546 males aged 55-85 years by exploring the associations of AHM use with AA and its change rate (Δ) in two visits with a median follow-up of 3. Read More
Aging (Albany NY) 2018 Nov;10(11):3273-3282
Department of Urology, Zhenjiang First People's Hospital, Zhenjiang 212002, China.
Spindle pole body component 25 (SPC25) is a component of NDC80 complex that controls spindle assembly checkpoint in the microtubule-binding domain of kinetochores. We recently showed that SPC25 is required for prostate cancer (PrC) cell proliferation and cell cycle progression, and here we investigated whether SPC25 may be a Cancer stem cell (CSC) marker in PrC. We found that the levels of SPC25 were higher in PrC samples than paired normal prostate tissue. Read More
Aging (Albany NY) 2018 Nov;10(11):3260-3272
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia.
Recent experimental studies highlighted the role of hydrogen sulfide (HS) in aging and longevity. The cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE) are the key enzymes responsible for HS production. Here we investigated the geroprotective effects of and overexpression in . Read More
Aging (Albany NY) 2018 Nov;10(11):3185-3209
Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, China.
Now, numerous exciting findings have been yielded in the field of energy metabolism within glioma cells. In addition to aerobic glycolysis, multiple catabolic pathways are employed for energy production. However, the prognostic significance of energy metabolism in glioma remains obscure. Read More
Aging (Albany NY) 2018 Nov;10(11):3056-3057
Stroke Unit, Department of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain.
Aging (Albany NY) 2018 Nov;10(11):3054-3055
University of Utah Molecular Medicine Program, University of Utah, Salt Lake City, UT 84108, USA.
Aging (Albany NY) 2018 Nov;10(11):3052-3053
Department of Physiology, Cellular Physiology Research Group, Institute of Molecular Pathology Biomarkers, University of Extremadura, Caceres 10003, Spain.