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    Repeated superovulation increases the risk of osteoporosis and cardiovascular diseases by accelerating ovarian aging in mice.
    Aging (Albany NY) 2018 May 22. Epub 2018 May 22.
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
    Superovulation procedures and assisted reproductive technologies have been widely used to treat couples who have infertility problems. Although generally safe, the superovulation procedures are associated with a series of complications, such as ovarian hyper-stimulation syndrome, thromboembolism, and adnexal torsion. The role of long-term repeated superovulation in ovarian aging and especially in associated disorders such as osteoporosis and cardiovascular diseases is still unclear. Read More

    Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype.
    Aging (Albany NY) 2018 May 19. Epub 2018 May 19.
    Loss of functionality during aging of cells and organisms is caused and accompanied by altered cell-to-cell communication and signalling. One factor thereby is the chronic accumulation of senescent cells and the concomitant senescence-associated secretory phenotype (SASP) that contributes to microenvironment remodelling and a pro-inflammatory status. While protein based SASP factors have been well characterized, little is known about small extracellular vesicles (sEVs) and their miRNA cargo. Read More

    Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice.
    Aging (Albany NY) 2018 May 20. Epub 2018 May 20.
    Glasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
    Dietary restriction (DR) is the most widely studied non-genetic intervention capable of extending lifespan across multiple taxa. Modulation of genes, primarily within the insulin/insulin-like growth factor signalling (IIS) and the mechanistic target of rapamycin (mTOR) signalling pathways also act to extend lifespan in model organisms. For example, mice lacking insulin receptor substrate-1 (IRS1) are long-lived and protected against several age-associated pathologies. Read More

    rs17655 G>C polymorphism associated with cancer risk: evidence from 60 studies.
    Aging (Albany NY) 2018 May 20. Epub 2018 May 20.
    Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzho, Zhejiang, 325027, China.
    Xeroderma pigmentosum group G (XPG), a key component in nucleotide excision repair pathway, functions to cut DNA lesions during DNA repair. Genetic variations that alter DNA repair gene expression or function may decrease DNA repair ability and impair genome integrity, thereby predisposing to cancer. The association between rs17655 G>C polymorphism and cancer risk has been investigated extensively, but the results remain contradictory. Read More

    Integrated analysis of colorectal cancer microRNA datasets: identification of microRNAs associated with tumor development.
    Aging (Albany NY) 2018 May 18. Epub 2018 May 18.
    Department of Biomedical and Biotechnological Sciences, University of Catania, Catania 95123, Italy.
    Colorectal cancer (CRC) is one of the leading cause of cancer death worldwide. Currently, no effective early diagnostic biomarkers are available for colorectal carcinoma. Therefore, there is a need to discover new molecules able to identify pre-cancerous lesions. Read More

    Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging.
    Aging (Albany NY) 2018 May 17. Epub 2018 May 17.
    Department of Analytical Biochemistry, Faculty of Biology and Agriculture, University of Rzeszow, Rzeszow 35-601, Poland.
    Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases. Read More

    Deacetylation of metabolic enzymes by Sirt2 modulates pyruvate homeostasis to extend insect lifespan.
    Aging (Albany NY) 2018 May 16. Epub 2018 May 16.
    State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
    Diapause in insects is akin to dauer in and hibernation in vertebrates. Diapause causes a profound extension of lifespan by low metabolic activity. However, the detailed regulatory mechanisms for low metabolic activity remain unknown. Read More

    Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice.
    Aging (Albany NY) 2018 May 16. Epub 2018 May 16.
    Division of Human Nutrition, Wageningen University and Research, 6708 WE, Wageningen, The Netherlands.
    The aging process is associated with diminished colonic health. In this study, we applied an integrative approach to reveal potential interactions between determinants of colonic health in aging C57BL/6J mice. Analysis of gut microbiota composition revealed an enrichment of various potential pathobionts, including spp, and a decline of the health-promoting spp and spp. Read More

    Age prediction of children and adolescents aged 6-17 years: an epigenome-wide analysis of DNA methylation.
    Aging (Albany NY) 2018 May 12. Epub 2018 May 12.
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
    The DNA methylation age, a good reflection of human aging process, has been used to predict chronological age of adults and newborns. However, the prediction model for children and adolescents was absent. In this study, we aimed to generate a prediction model of chronological age for children and adolescents aged 6-17 years by using age-specific DNA methylation patterns from 180 Chinese twin individuals. Read More

    Non-senescent tolerates severe disturbances in the nuclear lamina.
    Aging (Albany NY) 2018 May 10. Epub 2018 May 10.
    Zoological Institute, Christian-Albrechts University of Kiel, Kiel, D-24118, Germany.
    The cnidarian is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme longevity and non-senescence in long-living animals remains unknown. Here we analyze the role of a single lamin protein in non-senescence of . Read More

    Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma.
    Aging (Albany NY) 2018 May 11. Epub 2018 May 11.
    Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan, Hubei, 430071, P.R. China.
    E2F is a group of genes that encode a family of transcription factors (TFs) in higher eukaryotes and participate in cell cycle regulation and DNA synthesis in mammalian cells. Evidence from cell lines, mouse models, and human tissues indicates that TFs are implicated in lung cancer (LC) tumorigenesis. However, the diverse expression patterns and prognostic values of eight E2Fs have yet to be elucidated. Read More

    It is necessary to establish an International Agency for Research on Aging.
    Aging (Albany NY) 2018 May 12. Epub 2018 May 12.
    European Centre for Social Welfare Policy and Research, Vienna A-1230, Austria.
    The global aging of human population is one of the main challenges and opportunities of the 21st century. Establishing an International Agency for Research on Aging as an entity affiliated to one of the intergovernmental institutions, such as the World Health Organization, can be crucial for promoting international collaboration in gerontology, in particular in a search of effective and safe geroprotectors for humans. Read More

    A novel functional polymorphism of decrease glioblastoma susceptibility through inhibiting the binding of miR-139.
    Aging (Albany NY) 2018 May 10. Epub 2018 May 10.
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
    Glioblastoma (GBM) is the most commonly diagnosed solid tumor outside the central nervous system. However, genetic factors underlying GBM remain largely unclear. Previous studies indicated that Glial fibrillary acidic protein () might play an important role in the aggressiveness of GBM and also contributed to its poor overall survival. Read More

    CircRNAs in the tree shrew () brain during postnatal development and aging.
    Aging (Albany NY) 2018 Apr;10(4):833-852
    Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, China.
    Circular RNAs (circRNAs) are a novel type of non-coding RNA expressed across different species and tissues. At present, little is known about the expression and function of circRNAs in the tree shrew brain. In this study, we used RNA-seq to identify 35,007 circRNAs in hippocampus and cerebellum samples from infant (aged 47-52 days), young (aged 15-18 months), and old (aged 78-86 months) tree shrews. Read More

    Testosterone and dihydrotestosterone reduce platelet activation and reactivity in older men and women.
    Aging (Albany NY) 2018 May 2. Epub 2018 May 2.
    Department of Haemostatic Disorders, Medical University, Lodz, Poland.
    The cardiovascular effects of testosterone and dihydrotestosterone are generally attributed to their modulatory action on lipid and glucose metabolism. However, no studies suggest that circulating androgen levels influence the activation and reactivity of blood platelets - one of the main components of the haemostasis system directly involved in atherosclerosis. The levels of testosterone, dihydrotestosterone and oestradiol in plasma from men and women aged from 60 to 65 years were measured by LC-MS; the aim was to identify any potential relationships between sex steroid levels and the markers of platelet activation (surface membrane expression of GPII/IIIa complex and P-selectin) and platelet reactivity in response to arachidonate, collagen or ADP, monitored with whole blood aggregometry and flow cytometry. Read More

    Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue.
    Aging (Albany NY) 2018 Apr;10(4):701-746
    Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
    Caloric restriction (CR) has been extensively studied in rodents as an intervention to improve lifespan and healthspan. However, effects of CR can be strain- and species-specific. This study used publically available microarray data to analyze expression responses to CR in males from 7 mouse strains (C57BL/6J, BALB/c, C3H, 129, CBA, DBA, B6C3F1) and 4 tissues (epididymal white adipose tissue (eWAT), muscle, heart, cortex). Read More

    Coherent apoptotic and autophagic activities involved in regression of chicken postovulatory follicles.
    Aging (Albany NY) 2018 Apr;10(4):819-832
    Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.
    After ovulation in mammals, rupture of mature follicles is reorganized into the corpus luteum that secrets progesterone (P) to stimulate endometrial development. The situation in birds differs considerably. Beyond ovulation the ruptured avian follicle forms a postovulatory follicle (POF) that is not considered analogous to mammalian corpus luteum. Read More

    polymorphisms and neuroblastoma risk in Chinese children: a three-center case-control study.
    Aging (Albany NY) 2018 Apr;10(4):808-818
    Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzho, Zhejiang 325027, China.
    The genetic etiology of sporadic neuroblastoma remains largely obscure. and genes encode Ras-related nuclear protein and Ran-binding protein 2, respectively. These two proteins form Ran-RanBP2 complex that regulate various cellular activities including nuclear transport. Read More

    Age-associated bimodal transcriptional drift reduces intergenic disparities in transcription.
    Aging (Albany NY) 2018 Apr;10(4):789-807
    Development and Differentiation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, South Korea.
    This study addressed the question of how well the quantitative transcriptome structure established in early life is maintained and how consistently it appears with increasing age, and if there is age-associated alteration of gene expression (AGE), how much influence the Huntington's disease (HD) genotype exerts on it. We examined 285 exonic sequences of 175 genes using targeted PCR sequencing in skeletal muscle, brain, and splenic CD4+ T cells of wild-type and HD mice. In contrast to the muscle and brain, T cells exhibited large AGE, suggesting a strong contribution to functional decline of the organism. Read More

    Identifying circRNA-associated-ceRNA networks in the hippocampus of Aβ1-42-induced Alzheimer's disease-like rats using microarray analysis.
    Aging (Albany NY) 2018 Apr;10(4):775-788
    Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
    Alzheimer's disease (AD) is the most common form of dementia worldwide. Accumulating evidence indicates that non-coding RNAs are strongly implicated in AD-associated pathophysiology. However, the role of these ncRNAs remains largely unknown. Read More

    Novel role of autophagy-associated Pik3c3 gene in gonadal white adipose tissue browning in aged C57/Bl6 male mice.
    Aging (Albany NY) 2018 Apr;10(4):764-774
    Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
    Adipose tissue dysfunction is associated with inflammation, metabolic syndrome and other diseases in aging. Recent work has demonstrated that compromised autophagy activity in aging adipose tissue promotes ER stress responses, contributing to adipose tissue and systemic inflammation in aging. Phosphatidylinositol 3-kinase catalytic subunit type 3 (Pik3c3) is an 887 amino acid lipid kinase that regulates intracellular membrane trafficking and autophagy activity. Read More

    Oxidative stress-mediated senescence in mesenchymal progenitor cells causes the loss of their fibro/adipogenic potential and abrogates myoblast fusion.
    Aging (Albany NY) 2018 Apr;10(4):747-763
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
    Sarcopenia is the age-related loss of skeletal muscle mass and function. Skeletal muscle comprises diverse progenitor cells, including mesenchymal progenitor cells (MPCs), which normally support myogenic cell function but cause a decline in skeletal muscle function after differentiating into fibrous/adipose tissue. Cellular senescence is a form of persistent cell cycle arrest caused by cellular stress, including oxidative stress, and is accompanied by the acquisition of senescence-associated secretory phenotype (SASP). Read More

    Association of VAMP5 and MCC genetic polymorphisms with increased risk of Hirschsprung disease susceptibility in Southern Chinese children.
    Aging (Albany NY) 2018 Apr;10(4):689-700
    Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzho, Guangdong 510623, China.
    Hirschsprung disease (HSCR) is a genetic disorder characterized by the absence of neural crest cells in parts of the intestine. This study aims to investigate the association of vesicle-associated membrane protein 5 () and mutated in colorectal cancer () genetic polymorphisms and their correlated risks with HSCR. We examined the association in four polymorphisms (rs10206961, rs1254900 and rs14242 in , rs11241200 in ) and HSCR susceptibility in a Southern Chinese population composed of 1473 cases and 1469 controls. Read More

    Stress resistance and lifespan enhanced by downregulation of antimicrobial peptide genes in the Imd pathway.
    Aging (Albany NY) 2018 Apr;10(4):622-631
    Department of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Newark, NJ 07103, USA.
    Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25°C. Gene expression analysis between the flies developed at 18°C and 25°C revealed that the Immune deficiency (Imd) pathway, including the downstream antimicrobial peptides (AMPs), is downregulated in the flies developed at 18°C. Read More

    Sex differences in transcriptomic profiles in aged kidney cells of renin lineage.
    Aging (Albany NY) 2018 Apr;10(4):606-621
    Division of Nephrology, University of Washington, Seattle, WA 98109, USA.
    Renin expressing cells in the kidney's juxta-glomeruluar compartment likely also serve as progenitors for adult glomerular cells in disease. Although these cells of renin lineage (CoRL) decrease in number with advancing kidney age, accompanied by less responsiveness to typical stimuli such as ACE-inhibition, mechanisms and the impact of sex as a biological variable with age are not known. Accordingly, labeled CoRL were sorted from individual young (2m) and aged (27m) male and female Ren1cCre|ZsGreen reporter mice, and their transcriptomic profiles analyzed by RNA seq. Read More

    An epigenetic biomarker of aging for lifespan and healthspan.
    Aging (Albany NY) 2018 04;10(4):573-591
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
    Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite clinical measures of phenotypic age that capture differences in lifespan and healthspan may identify novel CpGs and facilitate the development of a more powerful epigenetic biomarker of aging. Using an innovative two-step process, we develop a new epigenetic biomarker of aging, DNAm PhenoAge, that strongly outperforms previous measures in regards to predictions for a variety of aging outcomes, including all-cause mortality, cancers, healthspan, physical functioning, and Alzheimer's disease. Read More

    Mining TCGA database for genes of prognostic value in glioblastoma microenvironment.
    Aging (Albany NY) 2018 Apr;10(4):592-605
    The Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
    Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to The Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression profiling and database mining for potential correlation between genes and overall survival of a variety of malignancies including GBM. Previous reports have shown that tumor microenvironment cells and the extent of infiltrating immune and stromal cells in tumors contribute significantly to prognosis. Read More

    Involvement of SPATA31 copy number variable genes in human lifespan.
    Aging (Albany NY) 2018 Apr;10(4):674-688
    Max-Planck Institute for Evolutionary Biology, 24306 Plön, Germany.
    The alias gene family belongs to the core duplicon families that are thought to have contributed significantly to hominoid evolution. It is also among the gene families with the strongest signal of positive selection in hominoids. It has acquired new protein domains in the primate lineage and a previous study has suggested that the gene family has expanded its function into UV response and DNA repair. Read More

    Physical decline and survival in the elderly are affected by the genetic variability of amino acid transporter genes.
    Aging (Albany NY) 2018 Apr;10(4):658-673
    Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
    Amino acid (AA) availability is a rate-limiting factor in the regulation of muscle protein metabolism and, consequently, a risk factor for age-related decline in muscle performance. AA transporters are emerging as sensors of AA availability and activators of mTORC1 signalling, acting as transceptors. Here, we evaluated the association of 58 single nucleotide polymorphisms (SNPs) in 10 selected AA transporter genes with parameters of physical performance (Hand Grip, Activity of Daily Living, Walking time). Read More

    AVE0991, a nonpeptide analogue of Ang-(1-7), attenuates aging-related neuroinflammation.
    Aging (Albany NY) 2018 Apr;10(4):645-657
    Department of Neurology, Nanjing First Hospital Nanjing Medical University, Nanjing, PR China.
    During the aging process, chronic neuroinflammation induced by microglia is detrimental for the brain and contributes to the etiology of several aging-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. As a newly identified axis of renin-angiotensin system, ACE2/Ang-(1-7)/MAS1 axis plays a crucial role in modulating inflammatory responses under various pathological conditions. However, its relationship with aging-related neuroinflammation is less studied so far. Read More

    KCNQ1OT1 promotes melanoma growth and metastasis.
    Aging (Albany NY) 2018 Apr;10(4):632-644
    Department of Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, China.
    Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. Read More

    A net-shaped multicellular formation facilitates the maturation of hPSC-derived cardiomyocytes through mechanical and electrophysiological stimuli.
    Aging (Albany NY) 2018 Apr;10(4):532-548
    Beijing Laboratory for Cardiovascular Precision Medicine, The Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing Collaborative Innovation Center for Cardiovascular Disorders, Anzhen Hospital, Capital Medical University, Beijing 100029, China.
    The use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is limited in drug discovery and cardiac disease mechanism studies due to cell immaturity. Although many approaches have been reported to improve the maturation of hiPSC-CMs, the elucidation of the process of maturation is crucial. We applied a small-molecule-based differentiation method to generate cardiomyocytes (CMs) with multiple aggregation forms. Read More

    Unrepaired DNA damage in macrophages causes elevation of particulate matter- induced airway inflammatory response.
    Aging (Albany NY) 2018 Apr;10(4):549-560
    Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Institute of Respiratory Diseases, Zhejiang University School of Medicine, Hangzhou 310009, China.
    The inflammatory cascade can be initiated with the recognition of damaged DNA. Macrophages play an essential role in particulate matter (PM)-induced airway inflammation. In this study, we aim to explore the PM induced DNA damage response of macrophages and its function in airway inflammation. Read More

    The evolution of CpG density and lifespan in conserved primate and mammalian promoters.
    Aging (Albany NY) 2018 Apr;10(4):561-572
    Department of Animal Sciences, University of Minnesota, College of Food, Agricultural, and Natural Resource Sciences, Saint Paul, MN 55108, USA.
    Gene promoters are evolutionarily conserved across holozoans and enriched in CpG sites, the target for DNA methylation. As animals age, the epigenetic pattern of DNA methylation degrades, with highly methylated CpG sites gradually becoming demethylated while CpG islands increase in methylation. Across vertebrates, aging is a trait that varies among species. Read More

    Associations between lncRNA polymorphisms and neuroblastoma risk in Chinese children.
    Aging (Albany NY) 2018 Mar;10(3):481-491
    Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzho, Guangdong 510623, China.
    Neuroblastoma is the third most common childhood cancer after leukemias and cancer of the central nervous system. Long noncoding RNA polymorphisms have been shown to confer cancer susceptibility; however, their roles in the genetic predisposition to neuroblastoma remain unclarified. To answer this question, we genotyped two polymorphisms, rs7158663 G>A and rs4081134 G>A, in 392 neuroblastoma children and 783 controls by TaqMan method. Read More


    Can Serum Cystatin C predict long-term survival in cardiac surgery patients?
    Aging (Albany NY) 2018 Mar;10(3):425-433
    Department of Medicine, Hypertension and Nephrology Unit, University Hospital Tor Vergata, Rome 00133, Italy.
    Renal dysfunction is a risk factor for morbidity and mortality in cardiac surgery patients. Serum Cystatin C (sCysC) is a well-recognized marker of early renal dysfunction but few reports evaluate its prognostic cardio-vascular role. The aim of the study is to consider the prognostic value of sCysC for cardiovascular mortality. Read More

    Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence.
    Aging (Albany NY) 2018 Mar;10(3):434-462
    Department of Genome Integrity, Institute of Molecular Genetics of the ASCR, Prague 14220, Czech Republic.
    Aging involves tissue accumulation of senescent cells (SC) whose elimination through senolytic approaches may evoke organismal rejuvenation. SC also contribute to aging-associated pathologies including cancer, hence it is imperative to better identify and target SC. Here, we aimed to identify new cell-surface proteins differentially expressed on human SC. Read More

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