2,790 results match your criteria Aging[Journal]


GABAergic astrocytes in Alzheimer's disease.

Aging (Albany NY) 2019 Mar 15. Epub 2019 Mar 15.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.18632/aging.101870DOI Listing

Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma - a retrospective study using TCGA database.

Aging (Albany NY) 2019 Mar 15. Epub 2019 Mar 15.

Department of Urology, Peking University First Hospital, Beijing, P.R. China.

m6A is the most common form of mRNA modification. However, little is known about its role in clear cell renal cell carcinoma (ccRCC). This study aims to identify gene signatures and prognostic values of m6A regulators in ccRCC. Read More

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http://dx.doi.org/10.18632/aging.101856DOI Listing

Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect.

Aging (Albany NY) 2019 Mar;11(5):1510-1523

Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

Aging is a degenerative process in which genome instability plays a crucial role. To gain insight into the link between organismal aging and DNA repair capacity, we analyzed DNA double-strand break (DSB) resolution efficiency in human mammary epithelial cells from 12 healthy donors of young and old ages. The frequency of DSBs was measured by quantifying the number of γH2AX foci before and after 1Gy of γ-rays and it was higher in cells from aged donors (ADs) at all times analyzed. Read More

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http://dx.doi.org/10.18632/aging.101849DOI Listing

mTOR in cerebrovascular disease.

Aging (Albany NY) 2019 Mar;11(5):1331-1332

Department of Cellular and Integrative Physiology, University of Texas Health San Antonio, TX 78229, USA.

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http://dx.doi.org/10.18632/aging.101869DOI Listing

microRNA-based biomarker for dementia.

Aging (Albany NY) 2019 Mar;11(5):1329-1330

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://www.aging-us.com/article/101868/text
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http://dx.doi.org/10.18632/aging.101868DOI Listing
March 2019
2 Reads

Influence of rapid eye movement sleep on all-cause mortality: a community-based cohort study.

Aging (Albany NY) 2019 Mar;11(5):1580-1588

Department of Critical Care Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Introduction: Although the proportion and duration of rapid eye movement (REM) sleep are correlated with neurological and cardiovascular diseases, whether REM sleep is associated with all-cause mortality in community-based populations remains unknown.

Methods: A prospective study was performed within the Sleep Heart Health Study (SHHS, Registration NO. NCT00005275). Read More

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http://www.aging-us.com/article/101858/text
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http://dx.doi.org/10.18632/aging.101858DOI Listing
March 2019
1 Read

Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia.

Aging (Albany NY) 2019 Mar;11(5):1524-1536

Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin 71-210, Poland.

The purpose of our investigation was to analyze the relationship between the serum levels of fatty acids and their metabolites and the levels of the selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). We determined serum concentrations of total (TT) and free testosterone (FT), insulin (I), dehydroepiandrosterone sulphate (DHEAS), luteinizing hormone and insulin-like growth factor 1 (IGF-1) and sex hormone-binding globulin (SHBG). Gas chromatography was performed. Read More

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http://dx.doi.org/10.18632/aging.101850DOI Listing

Hepatic resection for hepatocellular carcinoma in the octogenarian: is it justified?

Aging (Albany NY) 2019 Mar;11(5):1537-1550

Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Guishan, Taoyuan, Taiwan.

Liver resection is a standard treatment for hepatocellular carcinoma (HCC). The purpose of this study was to investigate the clinicopathological characteristics and long-term outcomes of octogenarians with HCC treated with liver resection. Records of patients who underwent liver resection for HCC were reviewed, and patients older and younger than 80 years were compared. Read More

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http://www.aging-us.com/article/101854/text
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http://dx.doi.org/10.18632/aging.101854DOI Listing
March 2019
1 Read

Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet.

Aging (Albany NY) 2019 Mar;11(5):1564-1579

Groningen Institute for Evolutionary Life Sciences, Dept of Behavioral Neuroscience, University of Groningen, Groningen, The Netherlands.

Diet and physical activity are thought to affect sustainable metabolic health and survival. To improve understanding, we studied survival of mice feeding a low-fat (LF) or high-saturated fat/high sugar (HFS) diet, each with or without free running wheel (RW) access. Additionally several endocrine and metabolic health indices were assessed at 6, 12, 18 and 24 months of age. Read More

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http://dx.doi.org/10.18632/aging.101857DOI Listing

Association of and gene polymorphisms with Wilms tumor risk: a four-center case-control study.

Aging (Albany NY) 2019 Mar;11(5):1551-1563

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.

Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether gene variants predispose individuals to Wilms tumor. Read More

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http://www.aging-us.com/article/101855/text
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http://dx.doi.org/10.18632/aging.101855DOI Listing
March 2019
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FoxD2-AS1 promotes glioma progression by regulating miR-185-5P/HMGA2 axis and PI3K/AKT signaling pathway.

Aging (Albany NY) 2019 Mar;11(5):1427-1439

Department of Neurosurgery, The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, Yunan Province, China.

Background/aims: The present study was aimed at exploring the role of long noncoding RNA (lncRNA) FOXD2-AS1 in the development and progression of glioma and the underlying mechanism of FOXD2-AS1/miR-185-5p/HMGA2 network in glioma via regulation of PI3K/Akt signaling pathway.

Methods: Microarray analysis was used for preliminary screening for candidate lncRNAs and mRNAs in glioma tissues. qRT-PCR and Western blot were used to determine the expression of FOXD2-AS1. Read More

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http://dx.doi.org/10.18632/aging.101843DOI Listing

Low triglyceride to high-density lipoprotein cholesterol ratio predicts hemorrhagic transformation in large atherosclerotic infarction of acute ischemic stroke.

Aging (Albany NY) 2019 Mar;11(5):1589-1601

Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.

The ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) is an objective approach to predicting poor outcomes in acute ischemic stroke (AIS). The impact of TG/HDL-C on hemorrhagic transformation (HT) after AIS remains unknown. The aim of this study was to explore the accurate effect of TG/HDL-C on HT after AIS. Read More

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http://dx.doi.org/10.18632/aging.101859DOI Listing
March 2019
6.432 Impact Factor

SP1-induced lncRNA TINCR overexpression contributes to colorectal cancer progression by sponging miR-7-5p.

Aging (Albany NY) 2019 Mar;11(5):1389-1403

Surgical Oncology Department, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.

Mounting evidences have indicated that long noncoding RNAs (lncRNAs) play pivotal roles in human diseases, especially in cancers. Recently, TINCR was proposed to be involved in tumor progression. However, its role in colorectal cancer (CRC) remains elusive. Read More

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http://dx.doi.org/10.18632/aging.101839DOI Listing

Age-related cardiopathies gene editing.

Aging (Albany NY) 2019 Mar;11(5):1327-1328

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.18632/aging.101853DOI Listing

The long non-coding RNA PTTG3P promotes growth and metastasis of cervical cancer through PTTG1.

Aging (Albany NY) 2019 Mar;11(5):1333-1341

Gynecologic Oncology, Xinxiang City Central Hospital, Xinxian 453000, Henan, China.

The outgrowth and metastasis of cervical cancer (CC) contribute to its malignancy. Pituitary Tumor Transforming Gene 1 (PTTG1) is upregulated in many types of cancer, and enhances tumor cell growth and metastasis. However, the activation and regulation of PTTG1 in CC, especially by its pseudogene PTTG3P, have not been shown. Read More

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http://dx.doi.org/10.18632/aging.101830DOI Listing

Ventral tegmental area disruption in Alzheimer's disease.

Aging (Albany NY) 2019 Mar;11(5):1325-1326

Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.

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http://dx.doi.org/10.18632/aging.101852DOI Listing

A dual role for GRP in cardiovascular disease.

Aging (Albany NY) 2019 Mar;11(5):1323-1324

Centre of Marine Sciences (CCMAR), University of Algarve, Faro, Portugal.

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http://dx.doi.org/10.18632/aging.101851DOI Listing
March 2019
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Curcumin inhibits liver metastasis of gastric cancer through reducing circulating tumor cells.

Aging (Albany NY) 2019 Mar;11(5):1501-1509

Department of Interventional Therapy, Zhongshan Hospital, University of Fudan, Shanghai 200032, China.

Primary gastric cancer (PGC) is the fourth most common malignant human cancer and the second leading cause of death worldwide. The majority of the subjects of PGC is diagnosed at a late stage, resulting in poor prognosis and therapeutic outcome, largely attributable to dissemination of tumor cells into circulation as circulating tumor cells (CTCs) and their formation of distal tumor. Curcumin is an active ingredient from the rhizome of the plant Curcuma longa. Read More

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http://dx.doi.org/10.18632/aging.101848DOI Listing
March 2019
6.432 Impact Factor

Integrated DNA methylation and gene expression analysis in the pathogenesis of coronary artery disease.

Aging (Albany NY) 2019 Mar;11(5):1486-1500

Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, China.

To evaluate DNA methylation sites and gene expression associated with coronary artery disease (CAD) and the possible pathological mechanism involved, we performed (1) genome-wide DNA methylation and mRNA expression profiling in peripheral blood datasets from the Gene Expression Omnibus repository of CAD samples and controls; (2) functional enrichment analysis and differential methylation gene regulatory network construction; (3) validation tests of 11 differential methylation positions of interest and the corresponding gene expression; and (4) correlation analysis for DNA methylation and mRNA expression data. A total of 669 differentially expressed mRNAs were matched to differentially methylated genes. After disease ontology, Kyoto Encyclopedia of Genes and Genomes pathway, gene ontology, protein-protein interaction and network construction and module analyses, 11 differentially methylated positions (DMPs) corresponding to 11 unique genes were observed: - cg26949694, - cg24381155, - cg02223351, - cg11267527, - cg27637738, - cg13104385, - cg20545410, - cg25613180, - cg00559992, - cg27178677 and - cg09247619. Read More

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http://dx.doi.org/10.18632/aging.101847DOI Listing

LINC00702 suppresses proliferation and invasion in non-small cell lung cancer through regulating miR-510/PTEN axis.

Aging (Albany NY) 2019 Mar;11(5):1471-1485

Department of Respiratory, the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.

Background: Long non-coding RNAs (lncRNAs) have been consistently reported to be involved in the progression of non-small cell lung cancer (NSCLC). In this study, we aimed to identify aberrantly expressed lncRNAs in NSCLC, in order to explore new therapeutic targets for NSCLC.

Methods: Two pairs of NSCLC and adjacent normal tissues were first analyzed by RNA sequencing. Read More

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http://dx.doi.org/10.18632/aging.101846DOI Listing
March 2019
4 Reads

Long intergenic non-coding LINC00657 regulates tumorigenesis of glioblastoma by acting as a molecular sponge of miR-190a-3p.

Aging (Albany NY) 2019 Mar;11(5):1456-1470

Prenatal Diagnosis Center, Hospital affiliated to Guizhou Medical University, Guiyang 550004, Guizhou, China.

To detect the aberrantly expressed long non-coding RNAs in glioblastoma, two pairs of glioblastoma and adjacent normal tissues were firstly analyzed by RNA sequencing. Long intergenic non-coding RNA LINC00657 was considered to play a vital role in glioblastoma based on the results of RNA sequencing. Hence, we aimed to investigate the mechanisms by which LINC00657 regulated the tumorigenesis of glioblastoma. Read More

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http://dx.doi.org/10.18632/aging.101845DOI Listing
March 2019
1 Read
6.432 Impact Factor

Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence.

Aging (Albany NY) 2019 Mar;11(5):1356-1388

State Key Laboratory of Genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences and Huashan Hospital, Fudan University, Shanghai 200438, China.

Down-regulated splicing factor SRSF3 is known to promote cellular senescence, an important biological process in preventing cancer and contributing to individual aging, via its alternative splicing dependent function in human cells. Here we discovered alternative polyadenylation (APA) dependent function of SRSF3 as a novel mechanism explaining SRSF3 downregulation induced cellular senescence. Knockdown of resulted in preference usage of proximal poly(A) sites and thus global shortening of 3' untranslated regions (3' UTRs) of mRNAs. Read More

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http://dx.doi.org/10.18632/aging.101836DOI Listing
March 2019
1 Read
6.432 Impact Factor

Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging.

Aging (Albany NY) 2019 Mar;11(5):1440-1456

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Cognition in adults shows variation due to developmental and degenerative components. A recent genome-wide association study identified genetic variants for general cognitive function in 148 independent loci. Here, we aimed to elucidate possible developmental and neurodegenerative pathways underlying these genetic variants by relating them to functional, clinical and neuroimaging outcomes. Read More

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http://dx.doi.org/10.18632/aging.101844DOI Listing
March 2019
2 Reads

Age-dependent co-dependency structure of biomarkers in the general population of the United States.

Aging (Albany NY) 2019 Feb;11(5):1404-1426

Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

Phenotypic biomarkers (e.g. cholesterol, weight, and glucose) are important to diagnose and treat diseases associated with aging. Read More

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http://dx.doi.org/10.18632/aging.101842DOI Listing
February 2019

MicroRNA-127 inhibits cell proliferation via targeting Kif3b in pancreatic β cells.

Aging (Albany NY) 2019 Mar;11(5):1342-1355

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

MicroRNAs (miRNAs) have been implicated in β cells dysfunction. Previous studies indicated that miR-127 was specifically abundant in β cells and one of its target genes, Kif3b, promoted cell proliferation. However, the impact of the miR-127-Kif3b axis on β cells remains unknown. Read More

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http://dx.doi.org/10.18632/aging.101835DOI Listing
March 2019
2 Reads
6.432 Impact Factor

Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction.

Aging (Albany NY) 2019 Feb;11(4):1283-1304

Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.

β-Hydroxybutyrate (HB) is a ketone body used as an energy source that has shown anti-inflammatory effects similar to calorie restriction (CR); Here, PGC-1α, an abundantly expressed co-factor in the kidney, was reported to interact with both FoxO1 and NF-κB although the definitive interactive mechanism has not yet been reported. In this study, we investigated whether renal aging-related inflammation is modulated by HB. We compared aged rats administered with HB to calorie restricted rats and examined the modulation of FoxO1 and the NF-κB pathway through interactions with PGC-1α. Read More

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http://dx.doi.org/10.18632/aging.101838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402511PMC
February 2019
6.432 Impact Factor

Alzheimer's disease as a multistage process: an analysis from a population-based cohort study.

Aging (Albany NY) 2019 Feb;11(4):1163-1176

Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.

In cancer research, multistage models are used to assess the multistep process that leads to the onset of cancer. In view of biological and clinical similarities between cancer and dementia, we used these models to study Alzheimer's disease (AD). From the population-based Rotterdam Study, we included 9,362 non-demented participants, of whom 1,124 developed AD during up to 26 years of follow-up. Read More

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http://dx.doi.org/10.18632/aging.101816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402512PMC
February 2019
1 Read

mA RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas.

Aging (Albany NY) 2019 Feb;11(4):1204-1225

Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital and Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin 300052, China.

N6-methyladenosine (mA) RNA methylation, associated with cancer initiation and progression, is dynamically regulated by the mA RNA methylation regulators ("writers", "erasers" and "readers"). Here, we demonstrate that most of the thirteen main mA RNA methylation regulators are differentially expressed among gliomas stratified by different clinicopathological features in 904 gliomas. We identified two subgroups of gliomas (RM1/2) by applying consensus clustering to mA RNA methylation regulators. Read More

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http://dx.doi.org/10.18632/aging.101829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402513PMC
February 2019
6.432 Impact Factor

DR region specific antibody ameliorated but ouabain worsened renal injury in nephrectomized rats through regulating Na,K-ATPase mediated signaling pathways.

Aging (Albany NY) 2019 Feb;11(4):1151-1162

Department of Biochemistry and Molecular Biology, Medical College of Xi'an Jiaotong University, Xi'an 710061, China.

Reduced Na-K-ATPase function is reported in various renal diseases. This implies that increase of Na-K-ATPase function may be a new target in treatment of renal injury. We previously reported that Na-K-ATPase was stabilized by DRm217, a specific antibody against DR region of Na-K-ATPase. Read More

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http://dx.doi.org/10.18632/aging.101815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402514PMC
February 2019
2 Reads

Longitudinal plasma metabolomics of aging and sex.

Aging (Albany NY) 2019 Feb;11(4):1262-1282

Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.

Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (WRAP), a cohort of participants who were dementia free at enrollment. Metabolomic profiles were quantified for 2,344 fasting plasma samples among 1,212 participants, each with up to three study visits. Read More

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http://dx.doi.org/10.18632/aging.101837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402508PMC
February 2019
1 Read

Class I PI3Ks in arterial thrombosis.

Aging (Albany NY) 2019 Feb;11(5):1321-1322

Institute of Cadiovascular and Metabolic Diseases, UMR 1048, University Toulouse III, Toulouse 31432, France.

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http://dx.doi.org/10.18632/aging.101841DOI Listing
February 2019
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Cardiac progenitors cells for vascular repair.

Aging (Albany NY) 2019 Feb;11(5):1319-1320

Cardiac Stem Cell group, Department of Immunology & Oncology, National Center for Biotechnology, Madrid 28049, Spain.

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http://dx.doi.org/10.18632/aging.101840DOI Listing
February 2019
1 Read

Pleiotropic effect of common variants in Hirschsprung disease and neuroblastoma.

Aging (Albany NY) 2019 Feb;11(4):1252-1261

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzho, Guangdong 510623, China.

Hirschsprung disease (HSCR) is a heterogeneous congenital disorder that affects the enteric nervous system, while neuroblastoma is an embryonal tumor of the sympathetic nervous system. Familial cases of both HSCR and neuroblastoma appear to be functionally linked to , which plays a key role in the development of neural crest derivatives. However, the association between common variants and disease risk is contested. Read More

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http://dx.doi.org/10.18632/aging.101834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402522PMC
February 2019
1 Read

Nutraceutical effects of in age-related macular degeneration.

Aging (Albany NY) 2019 Feb;11(4):1177-1188

Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA.

Gaetrn i.e., Indian gooseberry/ Amla) (EO) has been used extensively as a nutraceutical in several diseases since it is known to boost immunity and offers numerous health benefits such as antioxidant, anti-inflammatory, and anti-aging effects. Read More

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http://dx.doi.org/10.18632/aging.101820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402529PMC
February 2019
2 Reads

Stem cell-derived extracellular vesicles for myocardial infarction: a meta-analysis of controlled animal studies.

Aging (Albany NY) 2019 Feb;11(4):1129-1150

Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.

Stem cell-derived extracellular vesicles (EVs) have emerged as a promising therapy for myocardial infarction, but its effects remain incompletely understood. We aim to systematically review the efficacy of EVs on myocardial infarction in both small and large animals.On April 5, 2018, we searched the PubMed, Embase and Web of Science databases using variations of "myocardial infarction" and "extracellular vesicle". Read More

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http://dx.doi.org/10.18632/aging.101814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402509PMC
February 2019
1 Read

Towards a more precise and individualized assessment of breast cancer risk.

Aging (Albany NY) 2019 Feb;11(4):1305-1316

University of Vermont Cancer Center, The Robert Larner MD College of Medicine, University of Vermont, Burlington, VT 05405, USA.

Many clinically based models are available for breast cancer risk assessment; however, these models are not particularly useful at the individual level, despite being designed with that intent. There is, therefore, a significant need for improved, precise individualized risk assessment. In this Research Perspective, we highlight commonly used clinical risk assessment models and recent scientific advances to individualize risk assessment using precision biomarkers. Read More

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http://dx.doi.org/10.18632/aging.101803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402518PMC
February 2019

/miR-15b-5p/ mediates endothelial progenitor cells autophagy and affects coronary atherosclerotic heart disease via mTOR signaling pathway.

Aging (Albany NY) 2019 Feb;11(4):1089-1109

Department of Geriatric & General Practice, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China.

Present study focused on the influence of lncRNA on coronary atherosclerotic heart disease (CAD) by regulating miR-15b-5p/ and mTOR signaling pathway. Differentially expressed genes and activated pathway were investigated through bioinformatics analysis. QRT-PCR was conducted to verify expression of , miR-15b-5p and in CAD blood samples and endothelial progenitor cells (EPCs). Read More

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http://dx.doi.org/10.18632/aging.101766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402525PMC
February 2019

Epigenetic signature: implications for mitochondrial quality control in human aging.

Aging (Albany NY) 2019 Feb;11(4):1240-1251

Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende 87036, Italy.

Maintenance of functional mitochondria is essential to prevent damage leading to aging and diseases. What is more, the research of biomarkers of aging is focusing on better predicting functional capability along the lifetime beyond chronological age. Aim of this study was to identify novel CpG sites the methylation of which might be correlated to the chronological and biological age. Read More

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http://dx.doi.org/10.18632/aging.101832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402507PMC
February 2019
1 Read

The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality.

Aging (Albany NY) 2019 Feb;11(4):1110-1128

State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, Jiangsu, P.R. China.

Tight control of energy metabolism is essential for normal cell function and organism survival. PKM (pyruvate kinase, muscle) isoforms 1 and 2 originate from alternative splicing of PKM pre-mRNA. They are key enzymes in oxidative phosphorylation and aerobic glycolysis, respectively, and are essential for ATP generation. Read More

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http://dx.doi.org/10.18632/aging.101802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402520PMC
February 2019
1 Read

Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice.

Aging (Albany NY) 2019 Feb 14;11(3):1030-1044. Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Chemotherapy-induced ovarian aging not only increases the risk for early menopause-related complications but also results in infertility in young female cancer survivors. Oogonial stem cells have the ability to generate new oocytes and thus provide new opportunities for treating ovarian aging and female infertility. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural phenol derived from plants, that has been shown to have positive effects on longevity and redox flow in lipid metabolism and a preventive function against certain tumors. Read More

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http://www.aging-us.com/article/101808/text
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http://dx.doi.org/10.18632/aging.101808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382418PMC
February 2019
4 Reads

Methane alleviates sepsis-induced injury by inhibiting pyroptosis and apoptosis in vivo and in vitro experiments.

Aging (Albany NY) 2019 Feb;11(4):1226-1239

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Methane has been reported to have anti-oxidative, anti-apoptotic and anti-inflammatory properties. We investigated the potential protective effects of methane on sepsis-induced injury and determined the related mechanisms. Read More

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http://dx.doi.org/10.18632/aging.101831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402521PMC
February 2019
1 Read

Age and poverty status alter the coding and noncoding transcriptome.

Aging (Albany NY) 2019 Feb;11(4):1189-1203

Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Emerging evidence indicates that noncoding RNAs play regulatory roles in aging and disease. The functional roles of long noncoding RNAs (lncRNAs) in physiology and disease are not completely understood. Little is known about lncRNAs in the context of human aging and socio-environmental conditions. Read More

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http://dx.doi.org/10.18632/aging.101823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402526PMC
February 2019

Shared mechanisms: osteoporosis and Alzheimer's disease?

Aging (Albany NY) 2019 Feb;11(5):1317-1318

Department of Orthopedics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.18632/aging.101828DOI Listing
February 2019
1 Read

Potential role of miRNA-140 in Alzheimer's disease.

Aging (Albany NY) 2019 Feb;11(4):1087-1088

Cleveland Clinic Lerner Research Institute, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.18632/aging.101827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402524PMC
February 2019

Hallmarks of the cancer cell of origin: Comparisons with "energetic" cancer stem cells (e-CSCs).

Aging (Albany NY) 2019 Feb;11(3):1065-1068

Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester, M5 4WT, United Kingdom.

Here, we discuss the expected hallmark(s) of the cancer cell of origin and how this may be related to a new tumor cell phenotype, namely "energetic" cancer stem cells (e-CSCs). e-CSCs show many features that would be characteristic of the cancer cell of origin, including the over-expression of p21-WAF (CDKN1A), a key marker of senescence. It is tempting to speculate that the cancer cell of origin and e-CSCs are closely related entities. Read More

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http://www.aging-us.com/article/101822/text
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http://dx.doi.org/10.18632/aging.101822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382415PMC
February 2019
2 Reads

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.

Aging (Albany NY) 2019 Feb;11(3):986-1007

Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.

Spinocerebellar ataxia (SCA) type 17 is an autosomal dominant ataxia caused by expanded polyglutamine (polyQ) tract in the TATA-box binding protein (TBP). Substantial studies have shown involvement of compromised mitochondria biogenesis regulator peroxisome proliferator-activated receptor gamma-coactivator 1 alpha (PGC-1α), nuclear factor erythroid 2-related factor 2 (NRF2), nuclear factor-Y subunit A (NFYA), and their downstream target genes in the pathogenesis of polyQ-expansion diseases. The extracts of () and () have long been used as a Chinese herbal medicine (CHM). Read More

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http://dx.doi.org/10.18632/aging.101804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382417PMC
February 2019

Endothelial cells dictate cardiac fuel source.

Aging (Albany NY) 2019 Feb;11(4):1083-1084

Division Vascular Signaling and Cancer (A270), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

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http://dx.doi.org/10.18532/aging.101825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402510PMC
February 2019
2 Reads

Parkinson's disease as a systemic pathology.

Aging (Albany NY) 2019 Feb;11(4):1081-1082

Laboratory of Neurodegenerative Disorders, Department of Neurology-Hospital Clínic of Barcelona, IDIBAPS, UB, 08036 Barcelona, Catalonia.

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http://dx.doi.org/10.18632/aging.101824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402515PMC
February 2019

Measuring biological age in mice using differential mass spectrometry.

Aging (Albany NY) 2019 Feb;11(3):1045-1061

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Aging is an ill-defined process that increases the risk of morbidity and mortality. Aging is also heterogeneous meaning that biological and chronological age can differ. Here, we used unbiased differential mass spectrometry to quantify thousands of proteins in mouse liver and select those that that consistently change in expression as mice age. Read More

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http://dx.doi.org/10.18632/aging.101810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382423PMC
February 2019