4,339 results match your criteria Aging[Journal]


Articulation rehabilitation induces cortical plasticity in adults with non-syndromic cleft lip and palate.

Aging (Albany NY) 2020 Jul 3;12. Epub 2020 Jul 3.

School of Biomedical Engineering, Capital Medical University, Beijing, China.

In this study, we investigated brain morphological changes in adults with non-syndromic cleft lip and palate (NSCLP) after articulation rehabilitation (AR). High-resolution T1 weighted brain magnetic resonance imaging data were analyzed from 45 adults with NSCLP after palatoplasty: 24 subjects were assessed before AR (bNSCLP) and 21 subjects were assessed after AR (aNSCLP). In addition, there were 24 age and sex matched controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103402DOI Listing

Role of CPEB3 protein in learning and memory: new insights from synaptic plasticity.

Aging (Albany NY) 2020 Jul 2;12. Epub 2020 Jul 2.

Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.

The cytoplasmic polyadenylation element-binding (CPEB) protein family have demonstrated a crucial role for establishing synaptic plasticity and memory in model organisms. In this review, we outline evidence for CPEB3 as a crucial regulator of learning and memory, citing evidence from behavioral, electrophysiological and morphological studies. Subsequently, the regulatory role of CPEB3 is addressed in the context of the plasticity-related proteins, including AMPA and NMDA receptor subunits, actin, and the synaptic scaffolding protein PSD95. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103404DOI Listing

The Gαh/phospholipase C-δ1 interaction promotes autophagosome degradation by activating the Akt/mTORC1 pathway in metastatic triple-negative breast cancer.

Aging (Albany NY) 2020 Jul 1;12. Epub 2020 Jul 1.

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Lung metastasis (LM) is commonly found in triple-negative breast cancer (TNBC); however, the molecular mechanism underlying TNBC metastasis to lungs remains largely unknown. We thus aimed to uncover a possible mechanism for the LM of TNBC. Here we show that the phosphorylation of Akt and mTORC1 was positively but the autophagy activity was negatively correlated with endogenous Gαh levels and cell invasion ability in TNBC cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103390DOI Listing

Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway.

Aging (Albany NY) 2020 Jul 2;12. Epub 2020 Jul 2.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncanonical oncogenic pathway and is a novel therapeutic target. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103393DOI Listing

ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling.

Aging (Albany NY) 2020 Jul 2;12. Epub 2020 Jul 2.

Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

The receptor tyrosine kinase like orphan receptor 2 (ROR2) has been implicated in the pathogenesis of a variety of human cancers, including breast cancer. Here, we analyzed the clinical significance of ROR2 in breast cancer (BC) progression, and its function in the regulation of BC cell proliferation and growth. Analysis of mRNA levels in 45 BC tissues and adjacent non-tumor tissues revealed that expression was significantly increased in BC tissues, and that it correlated with tumor diameter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103400DOI Listing

rs12196996, a polymorphism at the gene flanking intron, is associated with circFOXO3 levels and the risk of coronary artery disease.

Aging (Albany NY) 2020 Jul 2;12. Epub 2020 Jul 2.

Institute of Aging Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, P.R. China.

CircFOXO3 plays an important role in the pathogenesis of coronary artery disease (CAD). Single nucleotide polymorphisms (SNPs) at circRNA flanking introns may change its back-splicing and influence circRNA formation. Here, we aimed to investigate the influence of the polymorphisms at the flanking introns on individual susceptibility to CAD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103398DOI Listing

circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the miR-145-5p/CXCL3 axis.

Aging (Albany NY) 2020 Jul 2;12. Epub 2020 Jul 2.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

In recent years, circular RNAs (circRNAs) have been increasingly reported to play a crucial role in the proliferation, migration, and invasion of non-small-cell lung cancer (NSCLC) cells. However, the circRNA MET (circMET) oncogenic mechanism that drives NSCLC development and progression remains largely unknown. In this study, the present results demonstrated that circMET expression was significantly higher in NSCLC tissues than in peritumoral tissues using quantitative real-time polymerase chain reaction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103392DOI Listing

Efficacy and safety of an antithrombotic regimen for atrial fibrillation patients with acute coronary syndrome or those undergoing percutaneous coronary intervention: a meta-analysis.

Aging (Albany NY) 2020 Jul 1;12. Epub 2020 Jul 1.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

This study evaluated the benefit of dual therapy in reducing ischemic events in atrial fibrillation (AF) patients presenting with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). We searched PubMed, Cochrane Library, and ClinicalTrials.gov for randomized controlled trials (RCTs) comparing dual and triple therapies (oral anticoagulation plus aspirin and P2Y12 inhibitor) for AF patients with ACS or those undergoing PCI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103359DOI Listing

Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis.

Aging (Albany NY) 2020 Jul 1;12. Epub 2020 Jul 1.

Center for Joint Surgery, Southwest Hospital, Third Military Medical University, Army Medical University, Chongqing 400038, People's Republic of China.

Cell senescence is a chronic process associated with age-related degenerative diseases such as osteoarthritis (OA). Senescent cells (SnCs) accumulate in the articular cartilage and synovium, leading to OA pathologies. The accumulation of SnCs in the cartilage results in a senescence-associated secretory phenotype (SASP) and age-related inflammation and dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103177DOI Listing

Glycosylation end products mediate damage and apoptosis of periodontal ligament stem cells induced by the JNK-mitochondrial pathway.

Aging (Albany NY) 2020 Jun 30;12. Epub 2020 Jun 30.

Affiliated Hospital of Zunyi Medical University, Guizhou, China.

Background: Recent studies have confirmed the bidirectional relationship between the two and the exacerbation of periodontitis by type II diabetes mellitus (T2DM), the pathogenic mechanism has not yet been clarified, AGEs has been linked to the pathogenesis of both periodontitis and T2DM, JNK signaling pathway might play a important role to explain the inner mechanism.

Objectives: To study advanced glycation end products (AGEs) activate the innate immune system of the host by activating oxidative stress and affecting cellular signal transduction in periodontal ligament stem cells (PDLSCs);Results: TNF-α and/or AGEs can induce the formation of endogenous ROS in PDLSCs, thereby activating the downstream JNK signalling pathway, leading to the initiation of the mitochondria-mediated apoptotic pathway and the induction of PDLSC apoptosis.

Conclusion: we hypothesized that the JNK pathway is a key link in the apoptosis of PDLSCs mediated by TNF-α and/or AGEs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103304DOI Listing

MicroRNA-124 inhibits macrophage cell apoptosis via targeting p38/MAPK signaling pathway in atherosclerosis development.

Aging (Albany NY) 2020 Jun 30;12. Epub 2020 Jun 30.

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.

The objective of this study is to characterize the function of microRNA (miR)-124 in the process of coronary artery disease (CAD). Eighty patients, including 40 CAD patients and 40 non-CAD control patients were enrolled in this study. Atherosclerosis model was established in -/- mice and in RAW264. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103387DOI Listing

A novel molecular-clinicopathologic nomogram to improve prognosis prediction of hepatocellular carcinoma.

Aging (Albany NY) 2020 Jun 30;12. Epub 2020 Jun 30.

Precision Medical Center Laboratory, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325015, Zhejiang Province, PR China.

Background: Emerging evidence suggests that long non-coding RNA (lncRNA) plays a crucial part in the development and progress of hepatocellular carcinoma (HCC). The objective was to develop novel molecular-clinicopathological prediction methods for overall survival (OS) and recurrence of HCC.

Results: An 8-lncRNA-based classifier for OS and a 14-lncRNA-based classifier for recurrence were developed by LASSO COX regression analysis, both of which had high accuracy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103350DOI Listing

Transcriptome analysis of common and diverged circulating miRNAs between arterial and venous during aging.

Aging (Albany NY) 2020 Jun 30;12. Epub 2020 Jun 30.

Medical Research Center, Peking University Third Hospital, Beijing 100191, China.

Circulating miRNAs have received extensive attention as non-invasive biomarkers for prediction and diagnosis of disease. However, most samples have been obtained from peripheral venous blood. To evaluate whether peripheral venous miRNAs represent circulating miRNAs from all blood vessels under a given condition, such as aging, we compared the miRNA profiles of venous and arterial plasma between young and aged rats by Illumina next-generation sequencing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103385DOI Listing

Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.

Aging (Albany NY) 2020 Jun 30;12. Epub 2020 Jun 30.

Department of Neurology, University Medicine, Greifswald, Germany.

The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy induced in brain cells. In Alzheimer's Disease, T-cells were identified as important mediators of disease pathology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103527DOI Listing

miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression.

Aging (Albany NY) 2020 Jun 29;12. Epub 2020 Jun 29.

Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001, China.

Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain after ICH. To investigate the effect of miRNA-183-5p on injury and repair of brain tissue after ICH, saline, miRNA-183-5p agomir, or miRNA-183-5p antagomir were injected into the lateral ventricles of 8-week-old mice with collagenase-induced ICH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103343DOI Listing

Quantitative proteomics analysis of young and elderly skin with DIA mass spectrometry reveals new skin aging-related proteins.

Aging (Albany NY) 2020 Jun 29;12. Epub 2020 Jun 29.

Department of Dermatology of First Affiliated Hospital, and Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China.

Skin aging is a specific manifestation of the physiological aging process that occurs in virtually all organisms. In this study, we used data independent acquisition mass spectrometry to perform a comparative analysis of protein expression in volar forearm skin samples from of 20 healthy young and elderly Chinese individuals. Our quantitative proteomic analysis identified a total of 95 differentially expressed proteins (DEPs) in aged skin compared to young skin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103461DOI Listing

Exosome-transmitted long non-coding RNA suppresses the progression of hepatocellular carcinoma.

Aging (Albany NY) 2020 Jun 27;12. Epub 2020 Jun 27.

Clinic Medicine Research Center of Hepatobiliary Diseases, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi Zhuang Autonomous Region, Baise 533000, China.

Extracellular communication mediated by exosomes in a tumor microenvironment can substantially affect tumor progression. However, the effect of exosomal long non-coding RNA on hepatocellular carcinoma (HCC) is still unclear. In this study, expressions in patients with HCC and healthy controls were detected and compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103302DOI Listing

Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1.

Aging (Albany NY) 2020 Jun 29;12. Epub 2020 Jun 29.

Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Centre for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai 200011, China.

Acute lung injury (ALI) is a syndrome associated with a high mortality rate. Nrf2 is a key regulator of intracellular oxidation homeostasis that plays a pivotal role in controlling lipid peroxidation, which is closely related to the process of ferroptosis. However, the intrinsic effect of Nrf2 on ferroptosis remains to be investigated in ALI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103378DOI Listing

Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.

Aging (Albany NY) 2020 Jun 27;12. Epub 2020 Jun 27.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes and MOE Key Laboratory of Tumor Molecular Biology, Institute of Life and Health Engineering, Jinan University, Guangzhou 510632, China.

Osteoporosis (OP) is an age-related osteolytic disease and characterized by low bone mass and more prone to fracture due to active osteoclasts. Proliferating cell nuclear antigen (PCNA) has been long identified as a nuclear protein playing critical roles in the regulation of DNA replication and repair. Recently, a few studies have demonstrated the cytoplasmic localization of PCNA and its function associated with apoptosis in neutrophil and neuroblastoma cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103434DOI Listing

Reversing immunosenescence for prevention of COVID-19.

Aging (Albany NY) 2020 Jun 28. Epub 2020 Jun 28.

Intervene Immune, Inc., Torrance, CA 90502, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103636DOI Listing

Five-lncRNA signature in plasma exosomes serves as diagnostic biomarker for esophageal squamous cell carcinoma.

Aging (Albany NY) 2020 Jun 28;12. Epub 2020 Jun 28.

Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, China.

Changes in expression of long non-coding RNAs (lncRNAs) in plasma exosomes can be useful for diagnosis of cancer patients. Here, we conducted a four-stage study to identify plasma exosome lncRNAs with diagnostic potential in esophageal squamous cell carcinoma (ESCC). First, plasma exosome lncRNA expression profiles were examined in ESCC patients, esophagitis patients, and healthy controls using RNA sequencing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103559DOI Listing

Expression and prognosis analysis of family in acute myeloid leukemia.

Aging (Albany NY) 2020 Jun 26;12. Epub 2020 Jun 26.

Department of Hematology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, JiangsuPeople's Republic of China.

DNA methyltransferases () by regulating DNA methylation play crucial roles in the progression of hematologic malignancies, especially for acute myeloid leukemia (AML). Accumulating investigations have identified the high incidence of mutation in AML, and it is correlated with poor prognosis. Although a few studies have shown the expression of and their clinical significance in AML, the results remain to be discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103520DOI Listing

miR-27-3p inhibition restore fibroblasts viability in diabetic wound by targeting NOVA1.

Aging (Albany NY) 2020 Jun 26;12. Epub 2020 Jun 26.

Department of Orthopedics, Suzhou Science and Technology Town Hospital, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou 215000, China.

Diabetic wounds increase morbidity and decrease quality of life in patients with type 2 diabetes. Serum miR-27-3p levels are reportedly elevated in type 2 diabetic patients. In the present study, we explored the role of miR-27-3p during wound healing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103266DOI Listing

Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial.

Aging (Albany NY) 2020 Jun 26;12. Epub 2020 Jun 26.

The Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf-Harofeh) Medical Center, Zerifin, Israel.

More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study's aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults.A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103571DOI Listing

Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019.

Aging (Albany NY) 2020 Jun 25;12. Epub 2020 Jun 25.

Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.

The aim of this study was to investigate the correlations between serum calcium and clinical outcomes in patients with coronavirus disease 2019 (COVID-19). In this retrospective study, serum calcium levels, hormone levels and clinical laboratory parameters on admission were recorded. The clinical outcome variables were also recorded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103526DOI Listing

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.

Aging (Albany NY) 2020 Jun 25;12. Epub 2020 Jun 25.

Department of Biology, University of Rochester, Rochester, NY 14627, USA.

When transcribed DNA is damaged, the transcription and DNA repair machineries must interact to ensure successful DNA repair. The mechanisms of this interaction in the context of chromatin are still being elucidated. Here we show that the SIRT6 protein enhances non-homologous end joining (NHEJ) DNA repair by transiently repressing transcription. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103567DOI Listing

CASC21, a FOXP1 induced long non-coding RNA, promotes colorectal cancer growth by regulating CDK6.

Aging (Albany NY) 2020 Jun 25;12. Epub 2020 Jun 25.

Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu, China.

Emerging studies indicate that long non-coding RNAs (lncRNAs) play crucial roles in colorectal cancer (CRC). Here, we reported lncRNA CASC21, which is induced by FOXP1, functions as an oncogene in CRC. We systematically elucidated its clinical significance and possible molecular mechanism in CRC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103376DOI Listing

Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes .

Aging (Albany NY) 2020 Jun 25;12. Epub 2020 Jun 25.

Department of Biotechnology, Institute of Biology and Biotechnology, University of Rzeszow, Rzeszow, Poland.

Remifentanil and other opioids are suggested to be protective against ischemia-reperfusion injury in animal models and coronary artery bypass surgery patients, however the molecular basis of such protection is far from being understood. In the present study, we have used a model of human cardiomyocytes treated with the hypoxia-mimetic agent cobalt chloride to investigate remifentanil preconditioning-based adaptive responses and underlying mechanisms. Hypoxic conditions promoted oxidative and nitrosative stress, p21-mediated cellular senescence and the activation of necroptotic pathway that was accompanied by a 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103604DOI Listing

Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin.

Aging (Albany NY) 2020 Jun 25;12. Epub 2020 Jun 25.

Metabolic Syndrome Group - BIOPROMET, Madrid Institute for Advanced Studies - IMDEA Food, CEI UAM+CSIC, Spain.

Senescent cells accumulate with obesity in the white adipose tissue of mice and humans. These senescent cells enhance the pro-inflammatory environment that, with time, contributes to the onset of glucose intolerance and type 2 diabetes. Glucose intolerance in mouse models of obesity has been successfully reversed by the elimination of senescent cells with the senolytic compounds navitoclax or the combination of dasatinib and quercetin (D/Q). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103607DOI Listing

hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis.

Aging (Albany NY) 2020 Jun 25;12. Epub 2020 Jun 25.

Department of Infectious Diseases and Lab of Liver Disease, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

Efforts have been made in the prevention and treatment of liver fibrosis. The inhibition or depletion of the hepatic stellate cells (HSCs) has been considered as a potential approach. Recently, there are numbers of studies about the role of the circular RNA in the disease progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103257DOI Listing

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice.

Aging (Albany NY) 2020 Jun 24;12. Epub 2020 Jun 24.

Institute of Neuroscience, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.

Autophagosome accumulation is observed in the distal axons of Alzheimer disease (AD) patients and AD animal models, suggesting that deficient retrograde transport and impaired autophagic clearance of beta-amyloid (A β) contribute to AD pathogenesis. Expression of the retrograde axonal transport-related protein dynein intermediate chain (DIC) is also reduced in AD patients, but the contributions of DIC to AD pathology remain elusive. This study investigated the effects of DIC expression levels on cognitive function, autophagosome axonal transport, and A β clearance in the APP/PS1 double transgenic mouse model of AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103382DOI Listing

Modulation of attention networks serving reorientation in healthy aging.

Aging (Albany NY) 2020 Jun 24;12. Epub 2020 Jun 24.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Orienting attention to behaviorally relevant stimuli is essential for everyday functioning and mainly involves activity in the dorsal and ventral frontoparietal networks. Many studies have shown declines in the speed and accuracy of attentional reallocation with advancing age, but the underlying neural dynamics remain less understood. We investigated this age-related decline using magnetoencephalography (MEG) and a Posner task in 94 healthy adults (22-72 years old). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103515DOI Listing

Agonism of GPR120 prevented IL-1β-induced reduction of extracellular matrix through SOX-9.

Aging (Albany NY) 2020 Jun 24;12. Epub 2020 Jun 24.

Department of Emergency Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001, Fujian, P.R. China.

Osteoarthritis (OA) is a whole-joint disease with extremely high prevalence. In all treatment approaches of OA, blocking the degradation of the cartilage extracellular matrix is an important treatment. In OA, overexpression of derivative enzymes leads to excessive catabolism and reduced synthesis of cartilage including type II collagen and aggrecan, which results in irreversible destruction of the joint. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103375DOI Listing

Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing.

Aging (Albany NY) 2020 Jun 24;12. Epub 2020 Jun 24.

MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, UK.

Ageing compromises skeletal muscle mass and function through poorly defined molecular aetiology. Here we have used untargeted metabolomics using UHPLC-MS to profile muscle tissue from young (=10, 25±4y), middle aged (=18, 50±4y) and older (=18, 70±3y) men and women (50:50). Random Forest was used to prioritise metabolite features most informative in stratifying older age, with potential biological context examined using the prize-collecting Steiner forest algorithm embedded in the PIUMet software, to identify metabolic pathways likely perturbed in ageing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103513DOI Listing

Androgen receptor affects the response to immune checkpoint therapy by suppressing PD-L1 in hepatocellular carcinoma.

Aging (Albany NY) 2020 Jun 24;12. Epub 2020 Jun 24.

Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with gender-related differences in onset and course. Androgen receptor (AR), a male hormone receptor, is critical in the initiation and progression of HCC. The role of AR in HCC has been mechanistically characterized and anti-AR therapies have been developed, showing limited efficacy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103231DOI Listing

Identification of an immune-related long non-coding RNA signature and nomogram as prognostic target for muscle-invasive bladder cancer.

Aging (Albany NY) 2020 06 24;12. Epub 2020 Jun 24.

Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China.

To identify an immune-related prognostic signature based on long non-coding RNAs (lncRNAs) and find immunotherapeutic targets for bladder urothelial carcinoma, we downloaded RNA-sequencing data from The Cancer Genome Atlas (TCGA) dataset. Functional enrichment analysis demonstrated bladder urothelial carcinoma was related to immune-related functions. We obtained 332 immune-related genes and 262 lncRNAs targeting immune-related genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103369DOI Listing

Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss.

Aging (Albany NY) 2020 Jun 24;12. Epub 2020 Jun 24.

Department of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Catania 95123, Italy.

Amyotrophic lateral sclerosis (ALS) is one of the most common motoneuronal disease, characterized by motoneuronal loss and progressive paralysis. Despite research efforts, ALS remains a fatal disease, with a survival of 2-5 years after disease onset. Numerous gene mutations have been correlated with both sporadic (sALS) and familiar forms of the disease, but the pathophysiological mechanisms of ALS onset and progression are still largely uncertain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103561DOI Listing

ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19.

Aging (Albany NY) 2020 Jun 23;12. Epub 2020 Jun 23.

Université Sorbonne Paris Nord, INSERM, U942, Cardiovascular Markers in Stressed Conditions, MASCOT, Bobigny 93000, France.

Background: To assess factors associated with one-month mortality among older inpatients with Covid-19.

Results: The mean age was 78 ± 7.8 years, 55. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103583DOI Listing
June 2020
6.432 Impact Factor

Risk factors for 2019 novel coronavirus disease (COVID-19) patients progressing to critical illness: a systematic review and meta-analysis.

Aging (Albany NY) 2020 Jun 23;12. Epub 2020 Jun 23.

Shengli Clinical Medical College, Fujian Medical University, Fuzhou 350001, Fujian, China.

Importance: With the rising number of COVID-19 cases, global health resources are strained by the pandemic. No proven effective therapies or vaccines for this virus are currently available. In order to maximize the use of limited medical resources, distinguishing between mild and severe patients as early as possible has become pivotal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103383DOI Listing

Physical activity, a modulator of aging through effects on telomere biology.

Aging (Albany NY) 2020 Jun 23;12. Epub 2020 Jun 23.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.

Aging is a complex process that is not well understood but involves finite changes at the genetic and epigenetic level. Physical activity is a well-documented modulator of the physiological process of aging. It has been suggested that the beneficial health effects of regular exercise are at least partly mediated through its effects on telomeres and associated regulatory pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103504DOI Listing

Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response.

Aging (Albany NY) 2020 Jun 23;12. Epub 2020 Jun 23.

Proteomics Unit, Universidad de Cádiz and Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz 11002, Spain.

Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide. To develop treatments that can stop or lessen the symptoms and severity of SARS-CoV-2 infection, it is critical to understand how the virus behaves inside human cells, and so far studies in this area remain scarce. A recent study investigated translatome and proteome host cell changes induced by SARS-CoV-2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103524DOI Listing

Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment.

Aging (Albany NY) 2020 Jun 23;12. Epub 2020 Jun 23.

Department of Physiology, School of Basic Medical Sciences, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, China.

Synaptic neurodegeneration of retinal ganglion cells (RGCs) is the earliest event in the pathogenesis of diabetic retinopathy. Our previous study proposed that impairment of mitochondrial trafficking by hyperphosphorylated tau is a potential contributor to RGCs synapse degeneration. However, other molecular mechanisms underlying mitochondrial defect in diabetic retinal neurodegeneration remain to be elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103446DOI Listing

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.

Aging (Albany NY) 2020 Jun 23;12. Epub 2020 Jun 23.

Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.

Humanin is a member of a new family of peptides that are encoded by short open reading frames within the mitochondrial genome. It is conserved in animals and is both neuroprotective and cytoprotective. Here we report that in the overexpression of humanin is sufficient to increase lifespan, dependent on . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103534DOI Listing

Clinical characteristics of older and younger patients infected with SARS-CoV-2.

Aging (Albany NY) 2020 Jun 22;12. Epub 2020 Jun 22.

Institute of Hepatology and Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: SARS-CoV-2 causes high mortality risk in older patients. This study aims to characterize the clinical features of older and younger SARS-CoV-2 infected patients.

Results: A total of 239 patients were divided into the younger group (<60 years; n=181) and the older group (≥60 years; n=58). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103535DOI Listing

Targeting CCL20 inhibits subarachnoid hemorrhage-related neuroinflammation in mice.

Aging (Albany NY) 2020 Jun 21;12. Epub 2020 Jun 21.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Recent evidence suggests that CC chemokine ligand 20 (CCL20) is upregulated after subarachnoid hemorrhage (SAH). Here, we investigated the functions of CCL20 in SAH injury and its underlying mechanisms of action. We found that CCL20 is upregulated in an SAH mouse model and in cultured primary microglia and neurons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103548DOI Listing

Components, regulation, and implications.

Aging (Albany NY) 2020 Jun 19. Epub 2020 Jun 19.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103528DOI Listing

Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects.

Aging (Albany NY) 2020 Jun 23;12. Epub 2020 Jun 23.

Faculty of Medicine and Health Technology and Finnish Cardiovascular Research Center Tampere, Tampere University, Tampere, Finland.

Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive and never-treated hypertensive volunteers (n=566, 19-72 years). STP and mean LTL were determined using Southern blotting, and supine hemodynamics recorded using continuous tonometric pulse wave analysis and whole-body impedance cardiography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103459DOI Listing

Endothelin-1 induces cellular senescence and fibrosis in cultured myoblasts. A potential mechanism of aging-related sarcopenia.

Aging (Albany NY) 2020 Jun 22;12. Epub 2020 Jun 22.

Unidad de Investigación de la Fundación para la Investigación Biomédica del Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid 28805, Spain.

Endothelial dysfunction, with increased endothelin-1 (ET-1) synthesis, and sarcopenia, characterized by the loss of muscular mass and strength, are two aging-related conditions. However, a relationship between them has not been already established. The aim of this study was to determine whether ET-1 induces senescence and fibrosis in cultured murine myoblasts, which could be involved in the development of sarcopenia related to aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103450DOI Listing

ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly.

Aging (Albany NY) 2020 Jun 22;12. Epub 2020 Jun 22.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.

Advanced age and apolipoprotein E () ε4 allele are both associated with increased risk of the Alzheimer's disease (AD). However, the extent of the joint contribution of ε4 allele and age on the brain white matter integrity, cognition and their relationship are unclear. We assessed the age-related variation differences of major cognitions in 846 non-demented elderly, and brain major white matter tracts in an MRI sub-cohort of 111 individuals between ε4 carriers and noncarriers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103367DOI Listing

Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway.

Aging (Albany NY) 2020 Jun 22;12. Epub 2020 Jun 22.

Department of Dermatology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, P.R. China.

Extracellular vesicles are involved in skin wound healing and diabetes. After enrichment and identification, plasma endothelial cells-derived-extracellular vesicles were cocultured with skin fibroblasts or HaCaT. The gain-and loss-of functions were performed to measure fibroblast proliferation, senescence, and reactive oxygen species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103366DOI Listing