186,805 results match your criteria Aggressive Behavior[Journal]


Clinicopathological characteristics of metaplastic breast cancer - analysis of the basic immunohistochemical profile and comparison with other invasive breast cancer types.

Breast 2018 Dec 7;43:135-141. Epub 2018 Dec 7.

Department of Biophysics and Human Physiology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland.

Introduction: Metaplastic breast cancer (MpBC) is a rare but aggressive type of breast cancer accounting for 0.25-1% of all diagnosed invasive breast cancers. Morphologically, it is characterized by differentiation of the neoplastic epithelium into squamous cells and/or mesenchymal-looking tissue. Read More

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December 2018

The influence of the OPRM1 (A118G) polymorphism on behavioral and neural correlates of aggression in healthy males.

Neuropharmacology 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen University, 52074, Aachen, Germany; JARA Institute Brain Structure Function Relationship Institute for Neuroscience and Medicine (INM 10), Forschungszentrum Jülich, 52425 Jülich, Germany.

Current models of aggression suggest that in addition to personality traits and environmental factors, biological vulnerability associated with genetics substantially impacts aggressive behavior. In a functional imaging study, we investigated the influence of the single nucleotide polymorphism of the mu 1 subtype opioid receptor gene (OPRM1), implicated in sociability, on correlates of trait and state aggression to delineate the function of these influences in aggression. A key aim was further to differentiate different aspects of aggressive reactions - namely, the reaction to provocation and the decision to punish an opponent. Read More

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December 2018

Darpp-32 and t-Darpp protein products of PPP1R1B: old dogs with new tricks.

Biochem Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry and Biochemistry, California State University, Los Angeles, CA, USA. Electronic address:

The PPP1R1B gene is located on chromosome 17q12 (39,626,208-39,636,626[GRCh38/hg38]), which codes for multiple transcripts and two experimentally-documented proteins Darpp-32 and t-Darpp. Darpp-32 (Dopamine and cAMP Regulated Phosphoprotein), discovered in the early 1980s, is a protein whose phosphorylation is upregulated in response to cAMP in dopamine-responsive tissues in the brain. It's phosphorylation profile modulates its ability to bind and inhibit Protein Phosphatase 1 activity, which, in turn, controls the activity of hundreds of phosphorylated proteins. Read More

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December 2018
2 Reads

Cytohistological correlation, immunohistochemistry and Murine Double Minute Clone 2 amplification of pulmonary artery intimal sarcoma: A case report with review of literature.

Diagn Cytopathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.

Pulmonary artery intimal sarcoma is a rare aggressive intraluminal tumor often misdiagnosed as acute or chronic pulmonary thromboembolism due to its clinical presentation and radiological findings. Thus early diagnosis is very crucial and may improve patient outcome. There is limited literature on diagnosis of pulmonary artery sarcoma by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Read More

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December 2018

Maternal and offspring MTHFR genotypes interact in a mouse model to induce ASD-like behavior.

Genes Brain Behav 2018 Dec 15:e12547. Epub 2018 Dec 15.

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Individuals with autism constitute a variable population whose members are spread along the autism spectrum. Sub-populations within that spectrum exhibit other conditions, such as anxiety, intellectual disabilities, hyperactivity and epilepsy, with different severities and co-occurrences. Among the genes associated with the increased risk for autism is the methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, which impairs one-carbon metabolic pathway efficiency. Read More

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December 2018

Sexual Aggression in Brazilian Nightclubs: Associations with Patron's Characteristics, Drug Use, and Environmental Factors.

Arch Sex Behav 2018 Dec 14. Epub 2018 Dec 14.

Department of Epidemiology, Columbia University, New York, USA.

Bars and nightclubs are main locations for sexual assault outcomes such as rape, attempted rape, stalking, and other forms of sexual harassment. Alcohol use is strongly associated with violence in nightlife settings. The present study aimed to identify individual and environmental factors, such as different types of nightclubs, music styles, and physical environment associated with nightclub patron's report of being victims of sexual aggression inside nightclubs in São Paulo, Brazil. Read More

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December 2018

Treatment of aggressive recurrent meningiomas: spinning towards peptide receptor radionuclide therapy.

Eur J Nucl Med Mol Imaging 2018 Dec 14. Epub 2018 Dec 14.

Service de Médecine Nucléaire, CHU Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.

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December 2018

Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells.

Oncogene 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Experimental Medicine, Centre of New Technologies, University of Warsaw, Warsaw, Poland.

Metastasis to distant organs is a major cause for solid cancer mortality, and the acquisition of migratory and invasive phenotype is a key factor in initiation of malignancy. In this study we investigated the contribution of Mixed-Lineage Kinase 4 (MLK4) to aggressive phenotype of breast cancer cells. Our TCGA cancer genomic data analysis revealed that amplification or mRNA upregulation of MLK4 occurred in 23% of invasive breast carcinoma cases. Read More

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December 2018

Spectrum and time course of epilepsy and the associated cognitive decline in duplication syndrome.

Neurology 2018 Dec 14. Epub 2018 Dec 14.

From the Departments of Neurology (D.M., B.S., R.S., D.G., V.N.P., A.M.G.) and Pediatrics (R.S., D.G.), Baylor College of Medicine, Houston, TX.

Objective: We characterized the epilepsy features and contribution to cognitive regression in 47 patients with duplication syndrome (MDS) and reviewed these characteristics in over 280 MDS published cases.

Methods: The institutional review board approved this retrospective review of medical records and case histories of patients with MDS.

Results: The average age at enrollment was 10 ± 7 years. Read More

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December 2018

-(2-(dimethylamino)ethyl)-4-F-fluorobenzamide: A Novel Molecular Probe for High-Contrast PET Imaging of Malignant Melanoma.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Chonnam National University Medical School, Korea, Republic of.

Malignant melanoma is a very aggressive and serious form of skin cancer, with prognosis and treatment outcome depending heavily on the clinical stage of the disease at the time of diagnosis. Here, we synthesized a novel F-labeled benzamide derivative to target melanoma, and then evaluated its biological characteristics in small animal models. : -(2-(dimethylamino)ethyl)-4-F-fluorobenzamide (F-DMFB) was synthesized by reaction of -succinimidyl 4-F-fluorobenzoate with ,-dimethylethylenediamine. Read More

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December 2018
1 Read

The ferredoxin-like protein, FerR, regulates PrbP activity in .

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Microbiology and Cell Science Department, Genetics Institute, Institute of Food and Agricultural Science, University of Florida, Gainesville, Florida, United States

In , PrbP is an important transcriptional accessory protein that regulates gene expression through interactions with the RNA polymerase β-subunit and a specific sequence on the promoter region. The constitutive expression of observed upon chemical inactivation of PrbP/DNA interactions indicated that the expression of was not auto-regulated at the level of transcription. This observation suggested that a modulatory mechanism via protein-protein interactions maybe involved. Read More

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December 2018
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A recurrent novel MGA-NUTM1 fusion identifies a new subtype of high grade spindle cell sarcoma.

Cold Spring Harb Mol Case Stud 2018 Dec 14. Epub 2018 Dec 14.

Memorial Sloan Kettering Cancer Center.

NUTM1-rearranged tumors are defined by the presence of a gene fusion between NUTM1 and various gene partners, and typically follow a clinically aggressive disease course with poor outcomes despite conventional multi-modality therapy. NUTM1-rearranged tumors display histologic features of a poorly differentiated carcinoma with areas of focal squamous differentiation and typically express the NUTM1-BRD4 fusion gene defining a distinct clinico-pathologic entity - NUT carcinoma (NC). NC with mesenchymal differentiation have rarely been described in the literature. Read More

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December 2018

Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.

Immunity 2018 Dec 1. Epub 2018 Dec 1.

Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

Serrated adenocarcinoma, an alternative pathway for colorectal cancer (CRC) development, accounts for 15%-30% of all CRCs and is aggressive and treatment resistant. We show that the expression of atypical protein kinase C ζ (PKCζ) and PKCλ/ι was reduced in human serrated tumors. Simultaneous inactivation of the encoding genes in the mouse intestinal epithelium resulted in spontaneous serrated tumorigenesis that progressed to advanced cancer with a strongly reactive and immunosuppressive stroma. Read More

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December 2018

The role of surgery in advanced disease for esophageal and junctional cancer.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:91-96. Epub 2018 Nov 24.

Department of Surgery, Erasmus MC - University Medical Center Rotterdam, PO BOX 2040, 3000, CA, Rotterdam, the Netherlands. Electronic address:

The incidence of esophageal and junctional cancer has been increasing in western industrialized nations in the past 30 years. At the time of diagnosis, approximately 50% of patients with esophageal and junctional cancers have distant metastases and are considered incurable. In the recent ESMO guidelines and the German S3 guidelines, surgical therapy for metastatic disease is not recommended. Read More

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November 2018

Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.

Leptin, a hormone secreted by peripheral adipose tissues, regulates the appetite in animals. Recently, evidence has shown that leptin also plays roles in behavioral response in addition to controlling appetite. In this study, we examined the potential function of leptin on non-appetite behaviors in zebrafish model. Read More

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December 2018
2.862 Impact Factor

MicroRNA-384 inhibits the progression of esophageal squamous cell carcinoma through blockade of the LIMK1/cofilin signaling pathway by binding to LIMK1.

Biomed Pharmacother 2019 Jan 5;109:751-761. Epub 2018 Nov 5.

Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, PR China. Electronic address:

Introduction: Esophageal squamous cell carcinoma (ESCC) represents an aggressive malignancy often accompanied with a poor prognosis. Owing to the poor mortality and morbidity rates associated with this malignancy, a deeper understanding of the finer molecular changes that occur in ESCC is required in order to identify novel potential targets for early detection and therapy. At present the mechanism by which ESCC functions on a molecular level is not fully understood. Read More

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January 2019

Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells.

Biomed Pharmacother 2019 Jan 5;109:2548-2560. Epub 2018 Dec 5.

Department of Experimental Diagnostic and Tumor Therapy N.N. Blokhin National Medical Research Center for Oncology, 115478, 24 Kashirskoe shosse, Moscow, Russia. Electronic address:

Melanoma is one of the most aggressive and treatment-resistant tumors that responsible for majority of skin-cancer related deaths. Here we propose a combination of MEK inhibitor binimetinib with metformin as a promising therapy against human melanoma cells in vitro, including BRAF -mutated A375, Mel Z, and Mel IL cells, and NRAS-mutated Mel MTP and Mel Me cells. Additionally, we obtained two close to clinical practice models of melanoma progression. Read More

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January 2019
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Repair or Replacement of Restorations: A Prospective cohort study by dentists in The National Dental Practice-Based Research Network.

Tex Dent J 2017 Jan;134(1):20-32

Background: A prospective cohort study that included dentists in The National Dental Practice-Based Research Network was conducted to quantify 12-month failures of restorations that were repaired or replaced at baseline. The study tested the hypothesis that no significant differences exist in failure percentages between repaired and replaced restorations after 12 months. It also tested the hypothesis that certain dentist, patient, and restoration characteristics are significantly associated with the incidence of restoration failure. Read More

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January 2017

Subtypes of aggression in intermittent explosive disorder.

J Psychiatr Res 2018 Oct 19;109:164-172. Epub 2018 Oct 19.

McLean Hospital, Harvard Medical School, United States.

Research in aggression has distinguished two major subtypes of aggressive behavior: hostile and instrumental. Previous research has examined these subtypes in healthy individuals and forensic samples but not in intermittent explosive disorder (IED), a disorder characterized by recurrent and severe aggressive behavior. We examined aggression subtypes in individuals with IED, healthy subjects, and psychiatric control subjects. Read More

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October 2018

The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

University of Saskatchewan, Department of Physiology, Saskatoon, SK, Canada.

Abnormalities in social behavior are a co-morbid symptom of idiopathic generalized epilepsies such as childhood absence epilepsy. The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model is a spontaneously occurring absence epilepsy phenotype closely correlated to that of human absence epilepsies. Similar to the human conditions, GAERS display social abnormalities. Read More

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December 2018

Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways.

Cancer Lett 2018 Dec 10. Epub 2018 Dec 10.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China; State Key Laboratory of Targeted Drug for Tumors of Guangdong Province, Guangzhou Double Bioproduct Inc., Guangzhou, China. Electronic address:

MLL-rearranged leukemia is an aggressive malignancy associated with poor outcome, which is refractory to conventional treatment. Melatonin has been proven to exert anti-tumor activity, but the effect of melatonin on MLL-r leukemia and the underlying mechanism remain poorly understood. In this study, melatonin inhibited cell proliferation and induced apoptosis by activating the caspase-dependent apoptotic pathway in MLL-r leukemia cells. Read More

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December 2018
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Multisensory Logic of Infant-Directed Aggression by Males.

Cell 2018 Dec;175(7):1827-1841.e17

Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

Newborn mice emit signals that promote parenting from mothers and fathers but trigger aggressive responses from virgin males. Although pup-directed attacks by males require vomeronasal function, the specific infant cues that elicit this behavior are unknown. We developed a behavioral paradigm based on reconstituted pup cues and showed that discrete infant morphological features combined with salivary chemosignals elicit robust male aggression. Read More

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December 2018
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The urothelial cell line UROtsa transformed by arsenite and cadmium display basal characteristics associated with muscle invasive urothelial cancers.

PLoS One 2018 14;13(12):e0207877. Epub 2018 Dec 14.

Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America.

Muscle invasive urothelial carcinomas are divided into various molecular subtypes with basal and luminal subtypes being the prominent ones. The basal muscle-invasive urothelial carcinomas are generally more aggressive at presentation and significantly enriched with squamous features. Our laboratory has developed an in-vitro model of urothelial cancer by transforming the immortalized cell line UROtsa with arsenite (As3+) and cadmium (Cd2+). Read More

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December 2018

Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel.

Background: Nonmelanoma skin cancers (NMSC) are the most common malignancies in solid organ recipients. We investigated the incidence, clinical features, and outcome of solid organ recipients with NMSC of the head and neck.

Methods: A retrospective chart review was conducted for solid organ recipients who were treated from 1992 to 2015 and who developed NMSC of the head and neck. Read More

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December 2018
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Treating Osteosarcoma with CAR T cells.

Scand J Immunol 2018 Dec 14:e12741. Epub 2018 Dec 14.

Laboratory of Translational Research & Immunomonitoring, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway.

Novel therapies to treat patients with solid cancers that have developed resistance to chemotherapy represent unmet needs of considerable dimensions. In the present review, we will address the attempts to develop Chimeric Antigen Receptor (CAR) targeted immunotherapy against osteosarcoma (OS). This aggressive cancer displays its peak incidence in children and young adults. Read More

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December 2018

Sofosbuvir and Ribavirin eradication of refractory hepatitis E in an immunosuppressed kidney transplant recipient.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Hepatitis E virus (HEV) infection is a self-limited asymptomatic illness in immunocompetent patients, but may cause chronic infection in immunosuppressed, solid organ transplant recipients. Chronic HEV can result in aggressive inflammation and fibrosis, leading to cirrhosis in up to 10%(1). Current therapy has been limited to reducing immunosuppression and/or ribavirin which leads to viral clearance in 64-74% of patients. Read More

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December 2018

The effect of body condition on postoperative recovery of dachshunds with intervertebral disc disease treated with postoperative physical rehabilitation.

Vet Surg 2018 Dec 13. Epub 2018 Dec 13.

College of Veterinary Medicine, University of Illinois, Urbana-Champaign, Illinois.

Objective: To determine the impact of obesity on postoperative recovery from thoracolumbar hemilaminectomy in dachshunds treated with rehabilitation.

Study Design: Prospective observational trial.

Animals: Thirty-two dachshunds with thoracolumbar intervertebral disk disease and pain perception. Read More

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December 2018
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Aggressive subcutaneous trichoblastomas successfully treated with Mohs micrographic surgery.

Australas J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Advocate Illinois Masonic Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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December 2018
1 Read

Behavioral and endocrine correlates of dominance in captive female Jackson's hartebeest (Alcelaphus buselaphus).

Zoo Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biology, Georgia Southern University, Statesboro, Georgia.

For species that form dominance hierarchies, such as group-living ungulates, aggressive interactions can pose a challenge to successful captive management. For example, Jackson's hartebeest (Alcelaphus buselaphus), a rare antelope of east Africa, can be difficult to maintain in captivity because aggression within female dominance hierarchies can lead to injury and death. We quantified behavioral and endocrine correlates of dominance in a captive herd of ten female hartebeest with the goal of understanding how to minimize dangerous interactions. Read More

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December 2018

Cutaneous mucormycosis.

Transpl Infect Dis 2018 Dec 13:e13039. Epub 2018 Dec 13.

Department of Hematology, AZ Delta Roeselare.

Mucormycosis is an aggressive invasive fungal infection that occurs rarely in immunocompetent but frequently in immunocompromised patients. We present a case of a 68-year old patient with cutaneous mucormycosis due to Rhizopus pusillus. He was initially hospitalized for invasive pulmonary aspergillosis and diabetes mellitus secondary to acute graft-versus-host treatment with glucocorticoids after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. Read More

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December 2018

Bendamustine as part of conditioning of autologous stem cell transplantation in patients with aggressive lymphoma: a phase 2 study from the GELTAMO group.

Br J Haematol 2018 Dec 12. Epub 2018 Dec 12.

Department of Haematology, Hospital Universitario de Salamanca - IBSAL, CIBERONC, Salamanca, Spain.

We conducted a phase 2 trial to evaluate the safety and efficacy of bendamustine instead of BCNU (carmustine) in the BEAM (BCNU, etoposide, cytarabine and melphalan) regimen (BendaEAM) as conditioning for autologous stem-cell transplantation (ASCT) in patients with aggressive lymphomas. The primary endpoint was 3-year progression-free survival (PFS). Sixty patients (median age 55 [28-71] years) were included. Read More

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December 2018
1 Read

Prospective cross-sectional study assessing prevalence and factors affecting trismus after multimodal treatment for oral cancers.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Department of Head and Neck Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background: Trismus is a common complication following treatment for oral cancers. However, its incidence in site-specific cancers is not adequately studied. The purpose of this study was to assess the prevalence and risk factors associated with trismus in treated patients with oral cancer. Read More

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December 2018

Germline mutations of renal cancer predisposition genes and clinical relevance in Chinese patients with sporadic, early-onset disease.

Cancer 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.

Background: An inherited susceptibility to renal cancers is associated with multiple predisposing genes, but most screening tests are limited to patients with a family history. Next-generation sequencing (NGS)-based multigene panels provide an efficient and adaptable tool for investigating pathogenic germline mutations on a larger scale. This study investigated the frequency of pathogenic germline mutations in renal cancer predisposition genes in patients with sporadic, early-onset disease. Read More

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December 2018

Programmed death ligand-1 is associated with tumor infiltrating lymphocytes and poorer survival in urothelial cell carcinoma of the bladder.

Cancer Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, China.

Drugs blocking programmed death ligand-1 (PD-L1) have shown unprecedented activity in metastatic and unresectable bladder cancer. The purpose of the present study was to investigate the expression, clinical significance and association of PD-L1 with tumor-infiltrating lymphocytes (TIL) in resectable urothelial cell carcinoma of the bladder (UCB). In this retrospective study, 248 UCB patients who received radical cystectomy or transurethral resection were examined. Read More

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December 2018

The effect of an aggressive behavior prevention program on kindergarten students.

Public Health Nurs 2018 Dec 11. Epub 2018 Dec 11.

Department of Public Health Nursing, Faculty of Health Sciences, Marmara University, Istanbul, Turkey.

Objectives: This quasi-experimental study with a pretest-posttest control group was conducted to determine the effects of the "Aggressive Behavior Prevention Program (ABPP)" on kindergarten students. The program was based on Social Cognitive Theory.

Design And Sample: The study was carried out with 90 children (intervention group = 45, control group = 45) who were registered in the kindergarten of a primary school. Read More

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December 2018

New graduate occupational therapists' narratives of ethical tensions encountered in practice.

Aust Occup Ther J 2018 Dec 11. Epub 2018 Dec 11.

School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Background/aim: Professionals in health and social care have high workloads and are working with diverse populations in hierarchical and complicated service delivery systems. There is increasing pressure on new graduates because they are expected to be immediately work ready and may not receive adequate support or supervision. It is well known that there can be issues with satisfaction and retention rates of new graduates due to the challenges they experience. Read More

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December 2018

Vulval Crohn disease: A case series of 26 patients.

Australas J Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Vulval Crohn disease is rare and likely under-reported, leading to difficulty in diagnosis and delay in treatment. In this case series, we report the clinical features and discuss therapy in 26 consecutive patients with vulval Crohn disease, with or without documented gastrointestinal disease, presenting between January 2016 and July 2018. We highlight the need for treatment that is in some cases more aggressive than the requirement to manage the patient's gastrointestinal involvement. Read More

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December 2018

Cause-specific mortality among medicare beneficiaries with newly diagnosed non-Hodgkin lymphoma subtypes.

Cancer 2018 Dec 11. Epub 2018 Dec 11.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: As the US population ages and non-Hodgkin lymphoma (NHL)-specific mortality declines, deaths from causes other than NHL will become increasingly important in treatment decision making for older patients with NHL. The objective of the current study was to describe how the 5-year cumulative incidence of NHL-specific and other-cause mortality varies by subtype, age, comorbidity level, and time since diagnosis in older patients.

Methods: Using the Surveillance, Epidemiology, and End Results cancer registry data linked to Medicare claims, patients aged ≥66 years were identified at the time of diagnosis with a first, primary NHL diagnosis from 2004 through 2013. Read More

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December 2018

Oncologic outcomes in prostate cancer patients treated with robot-assisted radical prostatectomy: results from a single institution series with more than 10 years follow up.

Minerva Urol Nefrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, OLV Aalst, Belgium.

Background: Robot-assisted radical prostatectomy (RARP) has gained increasing diffusion as standard of care in the surgical treatment of prostate cancer (PCa) patients, even in the absence of robust long-term oncologic comparative data. To report oncologic outcomes of RARP at more than 10 years follow up.

Methods: We retrospectively evaluated 173 consecutive PCa patients underwent RARP between 2002 and 2005 at a single European center with complete clinic and pathologic data and potential follow up of at least 10 years. Read More

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December 2018

Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors.

J Exp Clin Cancer Res 2018 Dec 14;37(1):314. Epub 2018 Dec 14.

The Irma H. Russo, MD Breast Cancer Research Laboratory, Fox Chase Cancer Center-Temple University Health System, Philadelphia, PA, 19111, USA.

Background: Triple negative breast cancer (TNBC) is an aggressive neoplasia with no effective therapy. Our laboratory has developed a unique TNBC cell model presenting epithelial mesenchymal transition (EMT) a process known to be important for tumor progression and metastasis. There is increasing evidence showing that epigenetic mechanisms are involved in the activation of EMT. Read More

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December 2018

A phase II study of a modified hyper-CVAD frontline therapy for patients with adverse risk diffuse large B-cell and peripheral T-cell non-Hodgkin lymphoma.

Leuk Lymphoma 2018 Dec 14:1-8. Epub 2018 Dec 14.

j Department of Haematology , Peter MacCallum Cancer Centre , Melbourne , Australia.

To improve complete remission (CR) rates by reducing toxicity and enhancing delivery, we created a modified hyper-CVAD/MA regimen (cyclophosphamide, vincristine, doxorubicin, dexamethasone/methotrexate, cytarabine) by reducing the cytarabine dose (3 g/m to 2 g/m) and number of cycles (eight to six). We conducted a phase II trial in the pre-rituximab era in the intermediate-high international prognostic index (IPI) (≥2) de novo diffuse large B-cell lymphoma (DLBCL) and peripheral T-cell lymphoma (PTCL) (ACTRN12605000105640). CR rates were compared with reported IPI-stratified rates. Read More

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December 2018
1 Read

An infant with primary pulmonary vein stenosis, associated with fatal occlusion of intraparenchymal small pulmonary veins.

J Cardiol Cases 2014 Jan 12;9(1):3-7. Epub 2013 Dec 12.

Japanese Research Institute of Pulmonary Vasculature, Japan.

Primary pulmonary vein stenosis (PVS) is rare within the pediatric population and its pathophysiology remains unclear, especially as to how the histopathology relates to its refractoriness to treatment. We report the case of a 4-month-old girl with primary PVS. The lesion in this patient was characterized by fatal obstruction of intraparenchymal small pulmonary veins, associated with localized stenosis at the four pulmonary veno-atrial junctions. Read More

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January 2014

Re-feeding syndrome and alcoholic cardiomyopathy: A case of interacting diagnoses.

J Cardiol Cases 2016 Sep 3;14(3):90-93. Epub 2016 Jun 3.

Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.

Re-feeding syndrome is an uncommon clinical entity of fluid and electrolyte disorders that typically occurs after re-initiation of enteral nutrition following prolonged fasting. This disorder can be complicated by left ventricular (LV) dysfunction, arrhythmias, and death. Alcohol abuse and anorexia nervosa are independently associated with similar complications. Read More

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September 2016

Progressive coronary aneurysms in Behçet disease, a journey through surgical and percutaneous treatment: A case report.

J Cardiol Cases 2016 Jul 14;14(1):32-34. Epub 2016 Apr 14.

Heart Center, King Faisal Hospital and Research Center, Riyadh, Saudi Arabia.

Behçet disease is a systemic autoimmune disease that causes inflammation within the vascular tree. Coronary arteries are rarely involved with stenosis, arteritis or aneurysm formation. Treatment is mainly directed to reduce the burden of inflammation systemically with steroid and immunosuppressive medications. Read More

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Sexual competition in a group of captive bonobos (Pan paniscus).

Primates 2000 Jan;41(1):109-115

Royal Zoological Society of Antwerp, K. Astridplein 28, 2018, Antwerp, Belgium.

We describe the occurrence of sexual competition, expressed as harassment of sexual interactions in a captive group of bonobos. We monitored all aggressive and pestering interventions during sexual interactions of three captive adult females, one adolescent, and three adult males. The study period covered two complete menstrual cycles for each female, with continuous daily observations. Read More

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January 2000

A case study of mother-son transfer in mountain gorillas.

Authors:
Pascale Sicotte

Primates 2000 Jan;41(1):93-101

Department of Anthropology, University of Calgary, 2500 University Dr N. W., T2N 1N4, Calgary, AB, Canada.

In mountain gorillas (Gorilla g. beringei), male immigration in bi-sexual units is rare. This paper presents the case of a nearly weaned male infant gorilla who followed his mother in her transfer. Read More

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January 2000

Impaired reconciliation in rhesus macaques with a history of early weaning and disturbed socialization.

Primates 2000 Jan;41(1):79-88

Division of Ethology, Department of Zoology, University of Stockholm, S-106 91, Stockholm, Sweden.

An attempt had been made to create five social groups from rhesus macaques with a history of early separation from their mothers, early weaning and hand feeding and, in most cases, previous housing in single cages. We investigated the exchange of affiliative behaviours after an aggressive encounter and selective attraction to the former opponent, a phenomenon previously well described in rhesus monkeys and called reconciliation. Evidence for reconciliation was only found in one of the five groups studied (corrected conciliatory tendency=13%). Read More

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January 2000

Function and distribution of coalitions in captive bonobos (Pan paniscus).

Primates 2000 Jul;41(3):249-265

Royal Zoological Society of Antwerp, K. Astridplein 28, 2018, Antwerp, Belgium.

We examined the distribution of support behaviour within a captive group of bonobos. Most support was evoked by inter-sexual conflicts with the two highest ranking females. Within a dyad, the usual winner was most often supported. Read More

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Infanticide of a newborn black-and-white colobus monkey (Colobus guereza) in Kibale National Park, Uganda.

Primates 2000 Apr;41(2):209-212

Department of Zoology, University of Florida, 223 Bartram Hall, 32611, Gainesville, Florida, USA.

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Recurrent intra-cardiac thrombosis-A unique presentation of prothrombin G20210 mutation.

J Cardiol Cases 2011 Jun 9;3(3):e129-e132. Epub 2011 Mar 9.

Department of Cardiology, University of Nevada School of Medicine, Las Vegas, NV, USA.

We report a 49-year-old female patient with recurrent large left ventricular thrombus on echocardiogram in an apparently normal heart and insignificant cardiac past medical history. She underwent an excision of the left ventricular mass, final biopsy on which proved it to be a thrombus. Postoperative anti-coagulation was initiated with enoxaparin and warfarin and the patient was followed up at a cardiology clinic 6 weeks later. Read More

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