6,483 results match your criteria Ageing Research Reviews[Journal]

Redox modulation of stress resilience by Crocus Sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy.

Mech Ageing Dev 2022 May 21:111686. Epub 2022 May 21.

Department of Biomedical and Biotechnological Sciences, University of Catania, 95125, via S. Sofia n.97, Catania, Italy. Electronic address:

Recent evidence demonstrates that Crocus Sativus L. (saffron) counteracts oxidative stress, mitochondrial dysfunction and neuroinflammation, closely linked to initiation and progression of major brain pathologies. Interestingly, saffron constituents such as crocin, crocetin and safranal can exert antioxidant or toxic effects depending on their endogenous concentration. Read More

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Hypoxia and hemorheological properties in older individuals.

Ageing Res Rev 2022 May 18;79:101650. Epub 2022 May 18.

Insitute of Sport Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1015, Lausanne, Switzerland.

Hypoxia is caused by insufficient oxygen availability for the organism leading to reduced oxygen delivery to tissues and cells. It has been regarded as a severe threat to human health and it is indeed implicated in pathophysiological mechanisms involved in the development and progression of many diseases. Nevertheless, the potential of controlled hypoxia interventions (i. Read More

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Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans - Evidence from untargeted mRNA and miRNA studies.

Ageing Res Rev 2022 May 18;79:101649. Epub 2022 May 18.

Université Clermont Auvergne, INRAE, UNH, F-63000 Clermont Ferrand, France; Department of Nutrition, University of California Davis, Davis, CA 95616, United States. Electronic address:

Cardiovascular and metabolic disorders present major causes of mortality in the ageing population. Polyphenols present in human diets possess cardiometabolic protective properties, however their underlying molecular mechanisms in humans are still not well identified. Even though preclinical and in vitro studies advocate that these bioactives can modulate gene expression, most studies were performed using targeted approaches. Read More

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What have we learned from genome-wide association studies (GWAS) in Parkinson disease?

Ageing Res Rev 2022 May 17:101648. Epub 2022 May 17.

Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, DE-72076 Tübingen, Germany. Electronic address:

After fifteen years of genome-wide association studies (GWAS) in Parkinson's disease (PD), what have we learned? Addressing this question will help catalogue the progress made towards elucidating disease mechanisms, improving the clinical utility of the identified loci, and envisioning how we can harness the strides to develop translational GWAS strategies. Here we review the advances of PD GWAS made to date while critically addressing the challenges and opportunities for next-generation GWAS. Thus, deciphering the missing heritability in underrepresented populations is currently at the reach of hand for a truly comprehensive understanding of the genetics of PD across the different ethnicities. Read More

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Inflammaging: The lesson of COVID-19 pandemic.

Mech Ageing Dev 2022 May 17:111685. Epub 2022 May 17.

Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy. Electronic address:

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The crucial mechanism and therapeutic implication of RNA methylation in bone pathophysiology.

Ageing Res Rev 2022 May 13;79:101641. Epub 2022 May 13.

Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, People's Republic of China. Electronic address:

Methylation is the most common posttranscriptional modification in cellular RNAs, which has been reported to modulate the alteration of RNA structure for initiating relevant functions such as nuclear translocation and RNA degradation. Recent studies found that RNA methylation especially N6-methyladenosine (mA) regulates the dynamic balance of bone matrix and forms a complicated network in bone metabolism. The modulation disorder of RNA methylation contributes to several pathological bone diseases including osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), and so on. Read More

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Defining and assessing intrinsic capacity in older people: A systematic review and a proposed scoring system.

Ageing Res Rev 2022 May 13;79:101640. Epub 2022 May 13.

i+HeALTH, European University Miguel de Cervantes, 47012 Valladolid, Spain; Faculty of Sport Sciences, European University of Madrid, Villaviciosa de Odón, 28670 Madrid, Spain.

Introduction: The World Health Organization has introduced the term 'intrinsic capacity' (IC) as a marker of healthy ageing. However, controversy exists on the definition and assessment of IC. We aimed to review the definitions and methods used for the assessment of IC in older adults. Read More

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Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project.

Mech Ageing Dev 2022 May 11;205:111684. Epub 2022 May 11.

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy; Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, Rome, Italy.

Aim: To determine the prevalence and associated factors of vitamin D deficiency in COVID-19 survivors and the relationship between vitamin D status and physical performance.

Methods: Vitamin D status was assessed in a sample of patients who had recovered from COVID-19 and were admitted to a post-acute outpatient service at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS (Rome, Italy). Participants were offered comprehensive medical assessment, including physical performance and muscle strength tests. Read More

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Oxidative stress and antioxidant defenses in mild cognitive impairment: A systematic review and meta-analysis.

Ageing Res Rev 2022 May 7;79:101639. Epub 2022 May 7.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Cognitive Impairment and Dementia Research Unit, Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; IMPACT Strategic Research Center, Deakin University, Geelong, Australia; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria. Electronic address:

This study aims to systematically review and meta-analyze the nitro-oxidative stress (O&NS)/antioxidant (ANTIOX) ratio in the peripheral blood of people with mild cognitive impairment (MCI). We searched PubMed, Scopus, Google Scholar, and Web of Science for articles published from inception until July 31, 2021. Forty-six studies on 3. Read More

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The NLRP3 inflammasome in fibrosis and aging: The known unknowns.

Ageing Res Rev 2022 May 5;79:101638. Epub 2022 May 5.

Department of Cardiology, Xi'an No.3 Hospital, School of Life Sciences and Medicine, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. School of Life Sciences and Medicine, Northwest University, Xi'an, China. Electronic address:

Aging-related diseases such as cancer, cardiovascular diseases, diabetes, and neurodegenerative diseases are often accompanied by fibrosis. The NLRP3 inflammasome triggers the inflammatory response and subsequently promotes fibrosis through pathogen-associated molecular patterns (PAMPs). In this review, we first introduce the general background and specific mechanism of NLRP3 in fibrosis. Read More

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Promise of irisin to attenuate cognitive dysfunction in aging and Alzheimer's disease.

Ageing Res Rev 2022 Jun 30;78:101637. Epub 2022 Apr 30.

Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, Texas A&M University College of Medicine, College Station, TX, USA. Electronic address:

Strategies proficient for relieving cognitive impairments in aging and Alzheimer's disease (AD) have an enormous impact. Regular physical exercise (PE) can prevent age-related dementia and slow down AD progression. However, such a lifestyle change is likely not achievable for individuals displaying age-related frailty. Read More

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Sortilin/Omentin-1 ratio in peripheral artery disease: A cross-sectional study on 295 unselected elderly patients.

Mech Ageing Dev 2022 Apr 29;205:111677. Epub 2022 Apr 29.

Medicina Interna Cardiovascolare, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Background: The role of sortilin and omentin-1 in the pathogenesis of atherosclerosis and vascular disease is an emerging topic in recent years. These molecules can be found circulating in the blood. Recent studies have shown how these biomarkers appear to correlate with the severity of PAD. Read More

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Neurogenesis in aging and age-related neurodegenerative diseases.

Ageing Res Rev 2022 Jun 29;78:101636. Epub 2022 Apr 29.

Section on DNA Repair, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

Adult neurogenesis, the process by which neurons are generated in certain areas of the adult brain, declines in an age-dependent manner and is one potential target for extending cognitive healthspan. Aging is a major risk factor for neurodegenerative diseases and, as lifespans are increasing, these health challenges are becoming more prevalent. An age-associated loss in neural stem cell number and/or activity could cause this decline in brain function, so interventions that reverse aging in stem cells might increase the human cognitive healthspan. Read More

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Pan-tissue methylation aging clock: Recalibrated and a method to analyze and interpret the selected features.

Mech Ageing Dev 2022 Jun 27;204:111676. Epub 2022 Apr 27.

Department of Biology, College of Natural Science, Chosun University, Gwangju 501-759, South Korea; BK21 FOUR Education Research Group for Age-Associated Disorder Control Technology, Department of Integrative Biological Science, Chosun University, Gwangju 501-759, South Korea. Electronic address:

The abundance of the biological data and the rapid evolution of the newer machine learning technologies have increased the epigenetics research in the last decade. This has enhanced the ability to measure the biological age of humans and different organisms via their omics data. DNA methylation array data are commonly used in the prediction of methylation age. Read More

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Melatonin: A novel candidate for the treatment of osteoarthritis.

Ageing Res Rev 2022 Jun 25;78:101635. Epub 2022 Apr 25.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China; Orthopaedic Institute, Medical College, Soochow University, Suzhou 215007, China. Electronic address:

Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and subchondral bone remodeling, is a common joint degenerative disease worldwide. OA pathogenesis is regulated by multiple predisposing factors, including imbalanced matrix metabolism, aberrant inflammatory response, and excessive oxidative stress. Moreover, melatonin has been implicated in development of several degenerative disorders owing to its potent biological functions. Read More

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Socially assistive robots for people with dementia: Systematic review and meta-analysis of feasibility, acceptability and the effect on cognition, neuropsychiatric symptoms and quality of life.

Ageing Res Rev 2022 Jun 21;78:101633. Epub 2022 Apr 21.

UCL Division of Psychiatry, London, UK. Electronic address:

Background: There is increasing interest in using robots to support dementia care but little consensus on the evidence for their use. The aim of the study is to review evidence about feasibility, acceptability and clinical effectiveness of socially assistive robots used for people with dementia.

Method: We conducted a systematic review and meta-analysis. Read More

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Assessment of cell cycle regulators in human peripheral blood cells as markers of cellular senescence.

Ageing Res Rev 2022 Jun 20;78:101634. Epub 2022 Apr 20.

Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia; Healthy Longevity Translational Researc h Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, the Netherlands. Electronic address:

Cellular senescence has gained increasing interest during recent years, particularly due to causal involvement in the aging process corroborated by multiple experimental findings. Indeed, cellular senescence considered to be one of the hallmarks of aging, is defined as a stable growth arrest predominantly mediated by cell cycle regulators p53, p21 and p16. Senescent cells have frequently been studied in the peripheral blood of humans due to its accessibility. Read More

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Life course socioeconomic conditions and multimorbidity in old age - A scoping review.

Ageing Res Rev 2022 Jun 14;78:101630. Epub 2022 Apr 14.

Population Health Laboratory (#PopHealthLab), University of Fribourg, Switzerland; Department of Readaptation and Geriatrics, University of Geneva, Switzerland.

Multimorbidity disproportionally affects individuals exposed to socioeconomic disadvantage. It is, however, unclear how adverse socioeconomic conditions (SEC) at different periods of the life course predict the occurrence of multimorbidity in later life. In this scoping review, we investigate the association between life course SEC and later-life multimorbidity, and assess to which extent it supports different life course causal models (critical period, sensitive period, accumulation, pathway, or social mobility). Read More

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Cellular senescence in the aging brain: A promising target for neurodegenerative diseases.

Mech Ageing Dev 2022 Jun 14;204:111675. Epub 2022 Apr 14.

Laboratory of Cellular and Molecular Neurobiology, School of Life Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India. Electronic address:

Aging is inevitable. Along with reduced ability to maintain the homeostasis of various biological processes, aging gradually deteriorates overall health. Extensive research on the aging brain has identified cellular senescence as a critical risk factor of neurodegeneration and cognitive decline. Read More

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Glial cells in Alzheimer's disease: From neuropathological changes to therapeutic implications.

Ageing Res Rev 2022 Jun 12;78:101622. Epub 2022 Apr 12.

Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address:

Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and progressively worsens over time. Although there has been increasing research interest in AD, its pathogenesis is still not well understood. Although most studies primarily focus on neurons, recent research findings suggest that glial cells (especially microglia and astrocytes) are associated with AD pathogenesis and might provide various possible therapeutic targets. Read More

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Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity.

Ageing Res Rev 2022 Jun 11;78:101621. Epub 2022 Apr 11.

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology, and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

Life expectancy has increased substantially over the last 150 years. Yet this means that now most people also spend a greater length of time suffering from various age-associated diseases. As such, delaying age-related functional decline and extending healthspan, the period of active older years free from disease and disability, is an overarching objective of current aging research. Read More

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Routine laboratory parameters, including complete blood count, predict COVID-19 in-hospital mortality in geriatric patients.

Mech Ageing Dev 2022 Jun 11;204:111674. Epub 2022 Apr 11.

Scientific Direction, IRCCS INRCA, Ancona, Italy.

To reduce the mortality of COVID-19 older patients, clear criteria to predict in-hospital mortality are urgently needed. Here, we aimed to evaluate the performance of selected routine laboratory biomarkers in improving the prediction of in-hospital mortality in 641 consecutive COVID-19 geriatric patients (mean age 86.6 ± 6. Read More

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Linking circadian rhythms to microbiome-gut-brain axis in aging-associated neurodegenerative diseases.

Ageing Res Rev 2022 Jun 8;78:101620. Epub 2022 Apr 8.

Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:

Emerging evidence suggests that both disruption of circadian rhythms and gut dysbiosis are closely related to aging-associated neurodegenerative diseases. Over the last decade, the microbiota-gut-brain axis has been an emerging field and revolutionized studies in pathology, diagnosis, and treatment of neurological disorders. Crosstalk between the brain and gut microbiota can be accomplished via the endocrine, immune, and nervous system. Read More

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VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila.

Mech Ageing Dev 2022 Jun 6;204:111673. Epub 2022 Apr 6.

Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China; Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China. Electronic address:

Gut homeostasis is a dynamically balanced state to maintain intestinal health. Vacuolar ATPases (V-ATPases) are multi-subunit proton pumps that were driven by ATP hydrolysis. Several subunits of V-ATPases may be involved in the maintenance of intestinal pH and gut homeostasis in Drosophila. Read More

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Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson's disease.

Ageing Res Rev 2022 Jun 5;78:101618. Epub 2022 Apr 5.

Department of Anatomy, School of Biomedical Science, Brain Health Research Centre, Brain Research New Zealand, University of Otago, Dunedin, New Zealand. Electronic address:

Parkinson's disease (PD) is the second most common age-associated neurodegenerative disorder and is characterised by progressive loss of dopamine neurons in the substantia nigra. Peripheral immune cell infiltration and activation of microglia and astrocytes are observed in PD, a process called neuroinflammation. Neuroinflammation is a fundamental response to protect the brain but, when chronic, it triggers neuronal damage. Read More

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Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease.

Ageing Res Rev 2022 May 5;77:101619. Epub 2022 Apr 5.

School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address:

As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering to their families and causes a heavy socioeconomic burden to society. A vast amount of funds and a mass of research have been devoted to elucidating the pathology of AD. However, the main pathogenesis is still elusive, and its mechanism is not completely clear. Read More

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Targeted protein degraders march towards the clinic for neurodegenerative diseases.

Ageing Res Rev 2022 Jun 1;78:101616. Epub 2022 Apr 1.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India. Electronic address:

Protein degraders are emerging as potent therapeutic tools to address neurological disorders and many complex diseases. It offered several key advantages, including the doses, drug resistance, and side effects over traditional occupancy-based inhibitors. Translation of chemical degraders into a clinical therapy for neurodegenerative disorders has a well-documented knowledge and resource gap. Read More

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Sarcopenia definition: Does it really matter? Implications for resistance training.

Ageing Res Rev 2022 Jun 1;78:101617. Epub 2022 Apr 1.

Institute for Health and Sport (IHES), Victoria University, Melbourne, VIC, Australia; Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, VIC, Australia; Western Health and the University of Melbourne, Department of Medicine, Footscray, VIC, Australia. Electronic address:

The loss of muscle mass, strength and function, known as sarcopenia, is common in older adults, and is associated with falls, fractures, cardiometabolic diseases, and lower quality of life. Sarcopenia can also occur secondarily to chronic diseases. Recently, sarcopenia was recognized as a disease with an International Classification of Disease (ICD) code, yet, at least five definitions for its clinical identification exist. Read More

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Immunosenescence and COVID-19.

Mech Ageing Dev 2022 Jun 1;204:111672. Epub 2022 Apr 1.

Department of Pathology and Experimental Rheumatology, Medical University of Gdańsk, Poland.

Ageing is associated with modified function of both innate and adaptive immunity. It is believed that changes occurring in ageing immune system are responsible for increased severity and deadliness of COVID-19 in the elderly. Although supported by statistics and epidemiology, these finding do not compute at the mechanistic level as depending solely on chronological and biological ageing. Read More

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Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder.

Mech Ageing Dev 2022 Jun 30;204:111670. Epub 2022 Mar 30.

Laboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, Valencia, Spain; Joint Unit for Rare Diseases IIS La Fe-CIPF, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain. Electronic address:

Huntington disease (HD) is a neurodegenerative disorder produced by an expansion of CAG repeats in the HTT gene. Patients of HD show involuntary movements, cognitive decline and psychiatric impairment. People carrying abnormally long expansions of CAGs (more than 35 CAG repeats) produce mutant huntingtin (mHtt), which encodes tracks of polyglutamines (polyQs). Read More

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