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    5426 results match your criteria Ageing Research Reviews [Journal]

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    Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases.
    Ageing Res Rev 2017 Nov 13. Epub 2017 Nov 13.
    Departments of Pathology and Genome Sciences, University of Washington, Seattle, WA 98195, USA.
    Werner syndrome (WS) is a heritable autosomal recessive human disorder characterized by the premature onset of several age-associated pathologies including cancer. The protein defective in WS patients, WRN, is encoded by a member of the human RECQ gene family that contains both a DNA exonuclease and a helicase domain. WRN has been shown to participate in several DNA metabolic pathways including DNA replication, recombination and repair, as well as telomere maintenance and transcription modulation. Read More

    'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age.
    Mech Ageing Dev 2017 Nov 13. Epub 2017 Nov 13.
    Institute for Cell and Molecular Biosciences (ICaMB), Ageing Research Laboratories, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne, NE4 5PL,United Kingdom; MRC/Arthritis Research UK Centre for Musculoskeletal Ageing (CIMA), United Kingdom. Electronic address:
    The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. Read More

    FOXO1/3: Potential suppressors of fibrosis.
    Ageing Res Rev 2017 Nov 11;41:42-52. Epub 2017 Nov 11.
    Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China. Electronic address:
    Fibrosis is a universally age-related disease that involves nearly all organs. It is typically initiated by organic injury and eventually results in organ failure. There are still few effective therapeutic strategy targets for fibrogenesis. Read More

    Autoamplificatory singlet oxygen generation sensitizes tumor cells for intercellular apoptosis-inducing signaling.
    Mech Ageing Dev 2017 Nov 11. Epub 2017 Nov 11.
    Institute of Virology, Medical Center - University of Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:
    Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase.

    Treatment: of tumor cells with high concentrations of H2O2, peroxnitrite, HOCl, or increasing the concentration of cell-derived NO causes initial generation of singlet oxygen and local inactivation of membrane-associated catalase. As a result, free peroxynitrite and H2O2 interact and generate secondary singlet oxygen. Read More

    The role of TGFβ in wound healing pathologies.
    Mech Ageing Dev 2017 Nov 11. Epub 2017 Nov 11.
    Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
    Wound healing is one of the most complex processes in multicellular organisms, involving numerous intra- and intercellular signalling pathways in various cell types. It involves extensive communication between the cellular constituents of diverse skin compartments and its extracellular matrix. Miscommunication during healing may have two distinct damaging consequences: the development of a chronic wound or the formation of a hypertrophic scar/keloid. Read More

    Connecting chaperone-mediated autophagy dysfunction to cellular senescence.
    Ageing Res Rev 2017 Nov 4;41:34-41. Epub 2017 Nov 4.
    Department of Neurodevelopment and Physiology, Institute of Cellular Physiology, National Autonomous University of México (UNAM), Mexico City, Mexico. Electronic address:
    Chaperone-mediated autophagy (CMA) is one of the main pathways of the lysosome-autophagy proteolytic system. It regulates different cellular process through the selective degradation of cytosolic proteins. In ageing, the function of CMA is impaired causing an inefficient stress response and the accumulation of damaged, oxidized or misfolded proteins, which is associated with numerous age-related diseases. Read More

    Oxidative stress in ageing and disease development studied by FT-IR spectroscopy.
    Mech Ageing Dev 2017 Nov 4. Epub 2017 Nov 4.
    National Technical University of Athens, Chemical Engineering Department, Radiation Chemistry & Biospectroscopy, Zografou Campus, 15780, Athens, Greece.
    FT-IR spectroscopy was used to investigate the effect of oxidative stress and to approach the mechanism on cancer bone demineralization, aortic valve mineralization and heterotopic ossification on disease development. The FT-IR spectra obtained from paediatric, adult bone and ex vivo irradiated adult healthy bone with a dose of 20Gy were compared with those of healthy bone. The increase of band intensity changes of vasCH2,vsCH2 in the region 3000-2850cm(-1) depended on aging, the disease progression and the dose of irradiation. Read More

    The role of cellular senescence in aging through the prism of Koch-like criteria.
    Ageing Res Rev 2017 Oct 26;41:18-33. Epub 2017 Oct 26.
    The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel. Electronic address:
    Since Hayflick's discovery of cellular senescence (CS), a great volume of knowledge in the field has been accumulated and intensively discussed. Here, we attempted to organize the evidence "for" and "against" the hypothesized causal role of CS in aging. For that purpose, we utilized robust Koch-like logical criteria, based on the assumption that some quantitative relationships between the accumulation of senescent cells and aging rate should exist. Read More

    Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure.
    Mech Ageing Dev 2017 Nov 8. Epub 2017 Nov 8.
    Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Department of Animal Science, North Carolina State University, Plants for Human Health Institute, NC Research Center, 28081, Kannapolis NC, USA. Electronic address:
    Epidemiological evidences have correlated airbone particulate matter (PM) to adverse health effects, mainly linking to pulmonary and cardiovascular disease. Nevertheless, only recently, some studies reported detrimental effects of PM on other organs such as skin. In a recent work, we have reported increased oxidative and inflammatory responses in Reconstituted Human Epidermis (RHE) exposed to ambient particles (CAPs) and we also demonstrated the ability of CAPs to penetrate the skin tissue. Read More

    OLR1 scavenger receptor knockdown affects mitotic gene expression but is dispensable for oxidized phospholipid- mediated stress signaling in SZ 95 sebocytes.
    Mech Ageing Dev 2017 Nov 2. Epub 2017 Nov 2.
    Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, Leitstelle 7J, A-1090 Vienna, Austria; Christian Doppler Laboratory for Biotechnology of Skin Aging, Austria. Electronic address:
    Phospholipid oxidation products (OxPL) are versatile stress signaling mediators in the skin. These lipid signaling molecules can be generated non-enzymatically or enzymatically by ultraviolet light, the major extrinsic skin aging factor. OxPL regulate cytoprotective, immunological and metabolic adaptation of the skin to oxidant stress. Read More

    p38 but not p53 is responsible for UVA-induced MCPIP1 expression.
    Mech Ageing Dev 2017 Nov 2. Epub 2017 Nov 2.
    Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Krakow, Poland. Electronic address:
    MCPIP1 (Monocyte Chemotactic Protein-1 Induced Protein) is an important regulator of inflammation and cell apoptosis, but its role in UVA-induced stress response in the epidermis has never been studied. We have found that moderate apoptosis-inducing dose of UVA (27J/cm(2)) increases the level of MCPIP1 expression in HaCaT cells and normal human keratinocytes (NHEK) within 6-9h after the treatment. MCPIP1 upregulation was dependent on the induction of p38, but not p53, as demonstrated by using p38 inhibitor SB203580 and p53 inducer RG7388, respectively. Read More

    Phagocyte NADPH oxidase, oxidative stress and lipids: Anti- or pro ageing?
    Mech Ageing Dev 2017 Nov 9. Epub 2017 Nov 9.
    Laboratoire de Chimie Physique, Université Paris Sud, UMR 8000, CNRS, 91405, Orsay Cedex, France. Electronic address:
    The role of NADPH oxidase in ageing is debated because of the dual roles of free radicals, toxic though necessary. In this paper we summarize some results about two aspects linked to the regulation of the activity of phagocyte NADPH oxidase (Nox2), encountered frequently in elderly people: inflammation and hypercholesterolemia. In the presence of a high amount of reactive oxygen species (ROS) created by itself or by any other source, the enzyme activity is mostly lowered. Read More

    Differential gene expression analysis in ageing muscle and drug discovery perspectives.
    Ageing Res Rev 2017 Nov 2;41:53-63. Epub 2017 Nov 2.
    CREMI, CHU de Québec Research Center, Quebec, Quebec, G1V 4G2, Canada; Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Quebec, G1V 4G2, Canada. Electronic address:
    Identifying therapeutic target genes represents the key step in functional genomics-based therapies. Within this context, the disease heterogeneity, the exogenous factors and the complexity of genomic structure and function represent important challenges. The functional genomics aims to overcome such obstacles via identifying the gene functions and therefore highlight disease-causing genes as therapeutic targets. Read More

    Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs "in vitro" wound closure.
    Mech Ageing Dev 2017 Nov 1. Epub 2017 Nov 1.
    Dept. of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Plants for Human Health Institute, Animal Sciences Dept., NC Research Campus, NC State University, NC, USA. Electronic address:
    Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids levels. Among the tissues where it is localized, SR-B1 has been shown to be significantly expressed in human epidermis. Read More

    The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE).
    Ageing Res Rev 2017 Oct 31. Epub 2017 Oct 31.
    Incyte Corporation, Wilmington, DA, USA. Electronic address:
    The human ageing process encompass mechanisms that effect a decline in homeostasis with increased susceptibility to disease and the development of chronic life-threatening illness. Increasing age affects the immune system which undergoes a progressive loss of efficiency, termed immunosenescence (ISC), to impact on quantitative and functional aspects of innate and adaptive immunity. The human demyelinating disease multiple sclerosis (MS) and the corresponding animal model experimental autoimmune encephalomyelitis (EAE) are strongly governed by immunological events that primarily involve the adaptive arm of the immune response. Read More

    Centenarians as a model to discover genetic and epigenetic signatures of healthy ageing.
    Mech Ageing Dev 2017 Oct 30. Epub 2017 Oct 30.
    Department of Pathobiology and Medical Biotechnologies, University of Palermo, 90134 Palermo, Italy.
    Centenarians are a model of successful ageing. The data favours the theory that, in order to live to 100, it is mandatory to inherit the right genetic variants from parents or acquire epigenetic variants through the environment. Therefore, the study of epigenetic signatures of healthy ageing is becoming an important aspect to identify the role of chromatin modification in ageing and understand how manage this fine-tuning system. Read More

    Inflammageing and metaflammation: The yin and yang of type 2 diabetes.
    Ageing Res Rev 2017 Oct 31;41:1-17. Epub 2017 Oct 31.
    Department of Cardiovascular Research, IRCCS MultiMedica, Milan, MI, Italy; Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
    Type 2 diabetes mellitus (T2DM) is characterised by chronic low-grade inflammation, recently referred to as 'metaflammation', a relevant factor contributing to the development of both diabetes and its complications. Nonetheless, 'canonical' anti-inflammatory drugs do not yield satisfactory results in terms of prevention of diabetes progression and of cardiovascular events, suggesting that the causal mechanisms fostering metaflammation deserve further research to identify new druggable targets. Metaflammation resembles ageing-induced low-grade inflammation, previously referred to as inflammageing, in terms of clinical presentation and the molecular profile, pointing to a common aetiology for both conditions. Read More

    Alzheimer's disease pathogenesis: Is there a role for folate?
    Mech Ageing Dev 2017 Oct 13. Epub 2017 Oct 13.
    Academic Urology Unit, Department of Oncology and Metabolism, University of Sheffield, United Kingdom.
    Epigenetic modifications, including changes in DNA methylation, have been implicated in a wide range of diseases including neurological diseases such as Alzheimer's. The role of dietary folate in providing methyl groups required for maintenance and modulation of DNA methylation makes it a nutrient of interest in Alzheimer's. Late onset Alzheimer's disease is the most common form of dementia and at present its aetiology is largely undetermined. Read More

    Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort.
    Mech Ageing Dev 2017 Oct 9;167:56-63. Epub 2017 Oct 9.
    Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00, Brno, Czech Republic; Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Kamenice 5, Building A29, 625 00, Brno, Czech Republic.
    Aging may be characterized as the progressive increase of the risk of death caused by a decrease of almost all bodily functions. While a great number of model organism studies have established the role of DNA double strand breaks (DSBs) as one of the main causes of aging, few studies have examined whether common polymorphisms in human DSB repair genes influence aging and mortality. More importantly, to the best of our knowledge, no longitudinal study has thus far examined the link between polymorphisms in DSB repair and the risk of death. Read More

    Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy.
    Ageing Res Rev 2017 Nov 7;40:142-148. Epub 2017 Oct 7.
    Dept. Communication Sciences & Disorders, 4202 E. Fowler Avenue, PCD1017 University of South Florida, Tampa, FL 33620-8200, USA; Global Center for Hearing & Speech Res., 3802 Spectrum Blvd., BPB Suite 210, University of South Florida Res. Park, Tampa, FL 33612, USA; Dept. Chemical & Biomedical Engineering, 4202 E Fowler Avenue, ENB 118 University of South Florida, Tampa, FL 33620, USA. Electronic address:
    Chronic, low-grade inflammation, or inflammaging, is a crucial contributor to various age-related pathologies and natural processes in aging tissue, including the nervous system. Over the past two decades, much effort has been done to understand the mechanisms of inflammaging in disease models such as type II diabetes, cardiovascular disease, Alzheimer's disease, Parkinson's disease, and others. However, despite being the most prevalent neurodegenerative disorder, the number one communication disorder, and one of the top three chronic medical conditions of our aged population; little research has been conducted on the potential role of inflammation in age-related hearing loss (ARHL). Read More

    Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging.
    Ageing Res Rev 2017 Nov 6;40:120-141. Epub 2017 Oct 6.
    Department of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:
    Cellular senescence (CS) is underlying mechanism of organism aging and is closely interconnected with age-related diseases (ARDs). Thus, any attempt that influences CS, may be undertaken to reverse or inhibit senescence, whereby could prolong healthy life span. Until now, two main proposes are epigenetic and genetic modifications of cell fate. Read More

    Telomere length, sibling competition and development of antioxidant defense in wild house mice.
    Mech Ageing Dev 2017 Oct 7. Epub 2017 Oct 7.
    Department of Biology, University of Turku, 20014 Turku, Finland.
    Antioxidants and telomere length are potential biomarkers for individuals' exposure and ability to cope with environmental stressors. However, intraspecific variations in antioxidant alterations due to natural, life cycle related stress, have been rarely estimated. We investigated those changes in wild-derived house mice in a longitudinal study with natural sibling competition as a stressor. Read More

    Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy for management.
    Ageing Res Rev 2017 Nov 3;40:149-167. Epub 2017 Oct 3.
    Department of Physiology Anatomy and Genetics, Sherrington Building, South Parks, Road Oxford, OX1 3PT, United Kingdom. Electronic address:
    The motor deficits which characterise the sporadic form of Parkinson's disease arise from age-related loss of a subset of dopamine neurons in the substantia nigra. Although motor symptoms respond to dopamine replacement therapies, the underlying disease process remains. This review details some features of the progressive molecular pathology and proposes deployment of a combination of nutrients: R-lipoic acid, acetyl-l-carnitine, ubiquinol, melatonin (or receptor agonists) and vitamin D3, with the collective potential to slow progression of these features. Read More

    DNA methylation age and perceived age in elderly Danish twins.
    Mech Ageing Dev 2017 Sep 28. Epub 2017 Sep 28.
    Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark; The Danish Twin Registry and the Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark.
    Perceived age is an easily accessible biomarker of aging. Here, we studied its relation to DNA methylation age (DNAm age) as introduced in (Horvath, 2013) in 180 elderly Danish twins. We found perceived age and DNAm age to be associated with chronological age (P=0. Read More

    A preliminary attempt to establish multiple stress response profiles of human skin fibroblasts exposed to mild or severe stress during ageing in vitro.
    Mech Ageing Dev 2017 Sep 22. Epub 2017 Sep 22.
    LVMH Research, St. Jean de Braye, France.
    Optimal stress response (SR) is an essential aspect of the property of dynamic homeostasis of all biological systems, including cells in culture. Whereas severe stress can induce the so-called stress-induced premature senescence (SIPS), a model developed by Olivier Toussaint, mild stress can strengthen homeodynamics and can postpone senescence through the phenomenon of hormesis. We have attempted to establish multiple stress response profiles (SRP) of early passage young and late passage senescent human facial skin fibroblasts, FSF-1, exposed to either mild (41°C) and severe (43°C) heat shock for 1h, or to mild (2%) and severe (0%) serum deprivation for up to 48h. Read More

    The role of the immune system in Alzheimer disease: Etiology and treatment.
    Ageing Res Rev 2017 Nov 21;40:84-94. Epub 2017 Sep 21.
    Department of Laboratory Medicine and Pathobiology, 1 King's College Circle, University of Toronto, ON M5S 1A8, Canada; Biological Sciences, Sunnybrook Research Institute,2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada. Electronic address:
    The immune system is now considered a major factor in Alzheimer Disease (AD). This review seeks to demonstrate how various aspects of the immune system, both in the brain and peripherally, interact to contribute to AD. We highlight classical nervous system immune components, such as complement and microglia, as well as novel aspects of the peripheral immune system that can influence disease, such as monocytes and lymphocytes. Read More

    Mitochondrial depletion in CD4(+) and CD19(+) peripheral lymphocytes in early stage Alzheimer's disease.
    Mech Ageing Dev 2017 Oct 18;167:24-29. Epub 2017 Sep 18.
    HLA Typing Laboratory, Yeditepe University Hospital, İstanbul, Turkey; Department of Immunology, Faculty of Medicine, Yeditepe University, İstanbul, Turkey.
    Alzheimer's disease (AD) may be associated with mitochondrial defects. The aim of the present study was to investigate changes in mitochondrial abundance in peripheral lymphocytes of early and late stage AD patients. We analysed levels of mitochondrial DNA (mtDNA) and mean fluorescence intensity (MFI) of the mitochondria-specific antibody 113-1 in CD4(+), CD8(+), CD19(+) and CD56(+) peripheral lymphocytes of early and late stage AD by quantitative real-time PCR and flow cytometry, respectively. Read More

    Autophagy, its mechanisms and regulation: Implications in neurodegenerative diseases.
    Ageing Res Rev 2017 Nov 18;40:64-74. Epub 2017 Sep 18.
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
    Autophagy is a major regulatory cellular mechanism which gives the cell an ability to cope with some of the destructive events that normally occur within a metabolically living cell. This is done by maintaining the cellular homeostasis, clearance of damaged organelles and proteins and recycling necessary molecules like amino acids and fatty acids. There is a wide array of factors that influence autophagy in the state of health and disease. Read More

    Age-dependent atrial arrhythmic phenotype secondary to mitochondrial dysfunction in Pgc-1β deficient murine hearts.
    Mech Ageing Dev 2017 Oct 14;167:30-45. Epub 2017 Sep 14.
    Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom. Electronic address:
    Introduction: Ageing and several age-related chronic conditions including obesity, insulin resistance and hypertension are associated with mitochondrial dysfunction and represent independent risk factors for atrial fibrillation (AF).

    Materials And Methods: Atrial arrhythmogenesis was investigated in Langendorff-perfused young (3-4 month) and aged (>12 month), wild type (WT) and peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β(-/-)) murine hearts modeling age-dependent chronic mitochondrial dysfunction during regular pacing and programmed electrical stimulation (PES).

    Results And Discussion: The Pgc-1β(-/-) genotype was associated with a pro-arrhythmic phenotype progressing with age. Read More

    Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis.
    Ageing Res Rev 2017 Nov 12;40:75-83. Epub 2017 Sep 12.
    Department of Geriatric Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Medical Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Neuropsychology and Rehabilitation Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands. Electronic address:
    Combined cognitive and physical exercise interventions have potential to elicit cognitive benefits in older adults with mild cognitive impairment (MCI) or dementia. This meta-analysis aims to quantify the overall effect of these interventions on global cognitive functioning in older adults with MCI or dementia. Ten randomized controlled trials that applied a combined cognitive-physical intervention with cognitive function as an outcome measure were included. Read More

    Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases.
    Ageing Res Rev 2017 Nov 10;40:51-63. Epub 2017 Sep 10.
    National Animal Transmissible Spongiform Encephalopathy Laboratory and Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China. Electronic address:
    Neurons are highly energy demanding cells dependent on the mitochondrial oxidative phosphorylation system. Mitochondria generate energy via respiratory complexes that constitute the electron transport chain. Adenosine triphosphate depletion or glucose starvation act as a trigger for the activation of adenosine monophosphate-activated protein kinase (AMPK). Read More

    Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain.
    Ageing Res Rev 2017 Nov 10;40:168-181. Epub 2017 Sep 10.
    Institute for Biochemical Research (INIBIOLP) - Histology B & Pathology B, School of Medicine, National University of La Plata, La Plata, Argentina. Electronic address:
    Aging is associated with a progressive increase in the incidence of neurodegenerative diseases, with Alzheimer's (AD) and Parkinson's (PD) disease being the most conspicuous examples. Within this context, the absence of efficacious therapies for most age-related brain pathologies has increased the interest in regenerative medicine. In particular, cell reprogramming technologies have ushered in the era of personalized therapies that not only show a significant potential for the treatment of neurodegenerative diseases but also promise to make biological rejuvenation feasible. Read More

    Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition.
    Ageing Res Rev 2017 Nov 9;40:95-119. Epub 2017 Sep 9.
    Department of Molecular Medicine, University of Padova, 35121 Padova, Italy; IMDEA-Food, 28049 Madrid, Spain.
    Ageing of the global population has become a public health concern with an important socio-economic dimension. Ageing is characterized by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed "inflammageing". The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defense, repair, turnover and adaptation of many tissues. Read More

    Regulated expression of the lncRNA TERRA and its impact on telomere biology.
    Mech Ageing Dev 2017 Oct 6;167:16-23. Epub 2017 Sep 6.
    Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico. Electronic address:
    The telomere protects against genomic instability by minimizing the accelerated end resection of the genetic material, a phenomenon that results in severe chromosome instability that could favor the transformation of a cell by enabling the emergence of tumor-promoting mutations. Some mechanisms that avoid this fate, such as capping and loop formation, have been very well characterized; however, telomeric non-coding transcripts, such as long non-coding RNAs (lncRNAs), should also be considered in this context because they play roles in the organization of telomere dynamics, involving processes such as replication, degradation, extension, and heterochromatin stabilization. Although the mechanism through which the expression of telomeric transcripts regulates telomere dynamics is not yet clear, a non-coding RNA component opens the research options in telomere biology and the impact that it can have on telomere-associated diseases such as cancer. Read More

    The role of nitric oxide in diabetic skin (patho)physiology.
    Mech Ageing Dev 2017 Sep 1. Epub 2017 Sep 1.
    Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia. Electronic address:
    The role of nitric oxide (NO) in cutaneous physiology/pathology became a growing research field since the discovery that almost all types of skin cells can synthetize this redox signaling molecule about 20 years ago. Now, it is evident that NO is an important player in skin physiological processes and in responses of cutaneous cells to external insults, while the impaired NO signaling has an important consequence in skin pathology. Skin disorders are common complications in diabetic conditions. Read More

    Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment.
    Mech Ageing Dev 2017 Oct 1;167:46-55. Epub 2017 Sep 1.
    Laboratory of Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224-6825, USA; Center for Translational Studies, Medical Service, VA Medical Center-DC, Washington DC, 20422, USA. Electronic address:
    During age-associated thymic involution, thymocytes decrease and lipid-laden cells accumulate. However, if and how aging affects the thymic lipid profile is not well understood, nor is it known if the hormonal milieu modifies this process. Here we demonstrate a correlation between reduced thymocyte numbers and markers of inflammation and oxidative stress with age. Read More

    Circadian clock as possible protective mechanism to pollution induced keratinocytes damage.
    Mech Ageing Dev 2017 Aug 30. Epub 2017 Aug 30.
    Department of Life Sciences and Biotechnology, Section of Medicinal and Health Products, University of Ferrara, I-44121 Ferrara, Italy; NC State University, Plants for Human Health Institute, Animal Science Dept., NC Research Campus, Kannapolis, NC 28081, USA. Electronic address:
    Ozone is among the most toxic environmental stressors to which we are continuously exposed. Due to its critical location, skin is one of the most susceptible tissues to oxidative stress damaging effect of ozone. An increasing collection of data suggests a significant role of circadian system in regulation of cellular response to oxidative stress. Read More

    Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study.
    Mech Ageing Dev 2017 Oct 8;167:1-4. Epub 2017 Sep 8.
    Department of Internal Medicine, Geriatrics Section, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; University Center for Geriatric Medicine, University Medical Center Groningen, Groningen, The Netherlands.
    Background: Melatonin plays a major role in maintaining circadian rhythm. Changes in melatonin metabolism might lead to circadian rhythm disturbances which are often observed in delirious patients.

    Aim: To assess if high morning plasma melatonin concentrations were associated with delirium. Read More

    The physiopathologic role of oxidative stress in skeletal muscle.
    Mech Ageing Dev 2017 Aug 26. Epub 2017 Aug 26.
    DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Italy; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Italy. Electronic address:
    Muscle senescence is a complex mechanism that is usually associated with a decrease in mass, strength and velocity of contraction. This state, known as sarcopenia, is a multifactorial process and it may be the consequence of several events, including accumulation of oxidative stress. The role of oxidative stress in the physiopathology of skeletal muscle is quite complex. Read More

    miRNAs in stem cell aging and age-related disease.
    Mech Ageing Dev 2017 Aug 25. Epub 2017 Aug 25.
    Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
    MicroRNAs (miRNAs) are short, non-coding RNAs that regulate the expression of mRNA targets and play a part in the post-transcriptional silencing. To date, the prominent roles of miRNAs in stem cells have been investigated in a wide range of biological processes, including self-renewal, differentiation and proliferation. In this commentary, we first demonstrate the causes and mechanisms of somatic stem cell aging in a new aspect of miRNAs. Read More

    Mechanisms of fetal epigenetics that determine telomere dynamics and health span in adulthood.
    Mech Ageing Dev 2017 Aug 26. Epub 2017 Aug 26.
    Laboratory for Molecular and Cellular Biology, Division of Molecular Biology, RBI, Zagreb, Croatia. Electronic address:
    Advances in epigenetics now enable us to better understand environmental influences on the genetic background of human diseases. This refers especially to fetal development where an adverse intrauterine environment impacts oxygen and nutrient supply to the fetus. Recently, differences in telomere length and telomere loss dynamics among individuals born with intrauterine growth restriction compared to normal controls have been described. Read More

    Genetically driven antioxidant capacity in a Caucasian Southeastern European population.
    Mech Ageing Dev 2017 Aug 26. Epub 2017 Aug 26.
    Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771, Athens, Greece. Electronic address:
    Previous studies have underlined the function of specific xenobiotic metabolizing phase-I or phase-II enzymes and endogenous antioxidant-related enzymes in the reduction and/or progression of oxidative stress and consequently the incidence of several diseases. In the present study, 10 polymorphic variants (rs4880, rs1799895, rs660339, rs1050450, rs1001179, rs28665122, rs1695, rs1138272, rs1051740 and rs2234922) were investigated in 1132 individuals of a Caucasian Southeastern European population. The frequency distribution of alleles and genotypes was compared to data of European (Northern, Central, Northwestern and Southwestern) and Global populations, extracted from the ensembl genome browser. Read More

    Role of DNA methylation in human age prediction.
    Mech Ageing Dev 2017 Sep 24;166:33-41. Epub 2017 Aug 24.
    Department of Neurology, Post Graduate Institute of Medical Education and Research(PGIMER), Chandigarh 160012, UT, India. Electronic address:
    DNA methylation (DNAm) is a fundamental biochemical modification which occurs over the lifespan of an individual and it is a significant component in the aging process. Methylation level of CpG sites plays an important role in finding the age of a person. Different approaches were used to extract age-related CpG (AR-CpG) sites for developing age-prediction models because the level of methylation is directly related to age for some CpG sites. Read More

    Age related depth profiles of human Stratum Corneum barrier-related molecular parameters by confocal Raman microscopy in vivo.
    Mech Ageing Dev 2017 Aug 24. Epub 2017 Aug 24.
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:
    In this study, stratum corneum (SC) depth profiles of hydrogen bound water molecule types, intercellular lipid (ICL) ordering, concentration of natural moisturizing factor (NMF) and keratin folding/unfolding properties are investigated in vivo for older (mean 50 years old) and younger (mean 29 years old) human skin using confocal Raman microscopy. The results show that the SC of the older group is modestly thicker (p<0.1), has more hydrogen bound water molecules at the depth 10-30% of the SC thickness (p<0. Read More

    Aging and immortality in unicellular species.
    Mech Ageing Dev 2017 Oct 24;167:5-15. Epub 2017 Aug 24.
    Graduate School of Arts and Sciences, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA. Electronic address:
    It has been historically thought that in conditions that permit growth, most unicellular species do not to age. This was particularly thought to be the case for symmetrically dividing species, as such species lack a clear distinction between the soma and the germline. Despite this, studies of the symmetrically dividing species Escherichia coli and Schizosaccharomyces pombe have recently started to challenge this notion. Read More

    HDAC inhibitors: A new promising drug class in anti-aging research.
    Mech Ageing Dev 2017 Sep 24;166:6-15. Epub 2017 Aug 24.
    Chebotarev State Institute of Gerontology NAMS of Ukraine, Kiev, Ukraine. Electronic address:
    In the last years, epigenetic regulation of gene expression is regarded as an important factor involved in a broad spectrum of aging-associated processes including loss of physical activity, frailty and genomic instability, and in development of various pathological conditions such as atherosclerosis, type 2 diabetes, cancer, immune deficits and neurodegenerative diseases. Accordingly, inhibitors of the members of superfamilies of histone deacetylases (HDACs) have been proposed, among other drugs targeting epigenetic pathways, as a promising type of therapeutics that is able to combat aging and its manifestations. The main focus of this article is a review of the literature describing the healthspan-promoting and life-extending effects of inhibitors of HDAC activity in both animal and clinical studies. Read More

    The senescent bystander effect is caused by ROS-activated NF-κB signalling.
    Mech Ageing Dev 2017 Aug 25. Epub 2017 Aug 25.
    The Ageing Biology Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK. Electronic address:
    Cell senescence is an important driver of the ageing process. The accumulation of senescent cells in tissues is accelerated by stress signals from senescent cells that induce DNA damage and ultimately senescence in bystander cells. We examine here the interplay of senescence-associated mitochondrial dysfunction (SAMD)-driven production of reactive oxygen species (ROS) and senescence-associated secretory phenotype (SASP) in causing the bystander effect. Read More

    Initiation of the age-related decline of odor identification in humans: A meta-analysis.
    Ageing Res Rev 2017 Nov 19;40:45-50. Epub 2017 Aug 19.
    School of Kinesiology, Shanghai University of Sport, 399 Chang Hai Road, Shanghai, 200438, P.R. China. Electronic address:
    Background: Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent or slow it.

    Objective: To determine the decade in which olfactory function begins to deteriorate in healthy humans by determining when odor identification is first impaired. Read More

    Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype.
    Mech Ageing Dev 2017 Sep 19;166:16-23. Epub 2017 Aug 19.
    Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address:
    Aging greatly increases the risk for intervertebral disc degeneration (IDD) as a result of proteoglycan loss due to reduced synthesis and enhanced degradation of the disc matrix proteoglycan (PG). How disc matrix PG homeostasis becomes perturbed with age is not known. The goal of this study is to determine whether cellular senescence is a source of this perturbation. Read More

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