5,607 results match your criteria Ageing Research Reviews [Journal]


The peculiar aging of human liver: A geroscience perspective within transplant context.

Ageing Res Rev 2019 Feb 14. Epub 2019 Feb 14.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; CIG-Interdepartmental Center "Galvani", University of Bologna, Bologna, Italy; CSR-Centro di Studio per la Ricerca dell'Invecchiamento, University of Bologna, Bologna, Italy.

An appraisal of recent data highlighting aspects inspired by the new Geroscience perspective are here discussed. The main findings are summarized as follows: i) liver has to be considered an immunological organ, and new studies suggest a role for the recently described cells named telocytes; ii) the liver-gut axis represents a crucial connection with environment and life style habits and may influence liver diseases onset; iii) the physiological aging of liver shows relatively modest alterations. Nevertheless, several molecular changes appear to be relevant: a) an increase of microRNA-31-5p; -141-3p; -200c-3p expressions after 60 years of age; b) a remodeling of genome-wide DNA methylation profile evident until 60 years of age and then plateauing; c) changes in transcriptome including the metabolic zones of hepatocyte lobules; d) liver undergoes an accelerated aging in presence of chronic inflammation/liver diseases in a sort of continuum, largely as a consequence of unhealthy life styles and exposure to environmental noxious agents. Read More

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http://dx.doi.org/10.1016/j.arr.2019.02.002DOI Listing
February 2019

The role of DNA methylation and hydroxymethylation in immunosenescence.

Ageing Res Rev 2019 Feb 12. Epub 2019 Feb 12.

Department of Human Genetics, Emory University, Atlanta, GA, USA; Population Biology, Ecology, and Evolution Program, Emory University, Atlanta, GA, USA.

A healthy functioning immune system is critical to stave off infectious diseases, but as humans and other organisms age, their immune systems decline. As a result, diseases that were readily thwarted in early life pose nontrivial harm and can even be deadly in late life. Immunosenescence is defined as the general deterioration of the immune system with age, and it is characterized by functional changes in hematopoietic stem cells (HSCs) and specific blood cell types as well as changes in levels of numerous factors, particularly those involved in inflammation. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.011DOI Listing
February 2019

Retraction notice to "Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing" [YNBDI 178 (2019) 1 - 8].

Mech Ageing Dev 2019 Mar;178:R1

Department of General Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, No. 301 Yanchangzhong Road, Shanghai 200072, China. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2019.02.002DOI Listing

Unravelling Protein Aggregation as an Ageing Related Process or a Neuropathological Response.

Ageing Res Rev 2019 Feb 11. Epub 2019 Feb 11.

Neuroscience and Signalling Laboratory, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal; The Discovery CTR, University of Aveiro Campus, 3810-193 Aveiro, Portugal. Electronic address:

Protein aggregation is normally associated with amyloidosis, namely motor neurone, Alzheimer's, Parkinson's or prion diseases. However, recent results have unveiled a concept of gradual increase of protein aggregation associated with the ageing process, apparently not necessarily associated with pathological conditions. Given that protein aggregation is sufficient to activate stress-response and inflammation, impairing protein synthesis and quality control mechanisms, the former is assumed to negatively affect cellular metabolism and behaviour. Read More

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http://dx.doi.org/10.1016/j.arr.2019.02.001DOI Listing
February 2019

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations.

Mech Ageing Dev 2019 Feb 6. Epub 2019 Feb 6.

Microbial Resources Division, Institute of Bioresources and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal, 795 001, Manipur, India. Electronic address:

Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Read More

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http://dx.doi.org/10.1016/j.mad.2019.02.001DOI Listing
February 2019

Post stroke depression and risk of stroke recurrence and mortality: A systematic review and meta-analysis.

Ageing Res Rev 2019 Jan 31;50:102-109. Epub 2019 Jan 31.

South London and Maudsley NHS Foundation Trust, London, United Kingdom; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Electronic address:

Background: Post stroke depression is a significant neuropsychiatric manifestation, predicting a range of poor outcomes. There are several studies investigating the association between post stroke depression and stroke recurrence/mortality, but results have been inconsistent.

Objective: A systematic review, meta-analysis and meta regression of observational studies assessing the association between post stroke depression and risk of stroke recurrence and mortality. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.013DOI Listing
January 2019
1 Read

Cell cycle arrest in replicative senescence is not an immediate consequence of telomere dysfunction.

Mech Ageing Dev 2019 Jan 30;179:11-22. Epub 2019 Jan 30.

King's College London, Faculty of Life Sciences & Medicine, Department of Anatomy, Guy's Campus, LONDON SE1 1UL, UK; St George's, University of London, Molecular and Clinical Sciences Research Institute, Mailpoint J2A, Cranmer Terrace, London, SW17 0RE, UK. Electronic address:

In replicative senescence, cells with critically-short telomeres activate a DNA-damage response leading to cell-cycle arrest, while those without telomere dysfunction would be expected to cycle normally. However, population growth declines more gradually than such a simple binary switch between cycling and non-cycling states would predict. We show here that late-passage cultures of human fibroblasts are not a simple mixture of cycling and non-cycling cells. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.009DOI Listing
January 2019

A systematic literature review and meta-analysis of real-world interventions for cognitive ageing in healthy older adults.

Ageing Res Rev 2019 Jan 29;50:110-130. Epub 2019 Jan 29.

Department of Psychology, Heriot-Watt University, Edinburgh, EH14 4AS, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. Electronic address:

Activities running in community-based-settings offer a method of delivering multimodal interventions to older adults beyond cognitive training programmes. This systematic review and meta-analysis investigated the impact of randomised controlled trials (RCTs) of 'real-world' interventions on the cognitive abilities of healthy older adults. Database searches were performed between October 2016 and September 2018. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.006DOI Listing
January 2019

Rodent models of frailty and their application in preclinical research.

Mech Ageing Dev 2019 Jan 28;179:1-10. Epub 2019 Jan 28.

Department of Pharmacology, Dalhousie University, Halifax, NS, Canada; Department of Medicine (Geriatric Medicine), Dalhousie University, Halifax, NS, Canada. Electronic address:

In clinical medicine, the concept of frailty is viewed as a state of high vulnerability to adverse health outcomes in people of the same age. Frailty is an important challenge because the loss of physiological reserve means that even minor stressors can lead to disability and death in those who are frail. Even so, the biology of frailty is not well understood. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.008DOI Listing
January 2019

The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease.

Ageing Res Rev 2019 Jan 25;50:89-101. Epub 2019 Jan 25.

Unité de Traffic Membranaire et Pathogénèse, Institut Pasteur, Paris, France. Electronic address:

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. PD is characterized by the loss of dopaminergic neurons, primarily in brain regions that control motor functions, thereby leading to motor impairments in the patients. Pathological aggregated forms of the synaptic protein, α-synuclein (α-syn), are involved in the generation and progression of PD. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.012DOI Listing
January 2019
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The optimal treatment for improving the cognitive function in elder people diagnosed with mild cognitive impairment incorporating Bayesian network meta-analysis and systematic review.

Ageing Res Rev 2019 Jan 22. Epub 2019 Jan 22.

School of Nursing, Medical College of Soochow University, Suzhou, PR China. Electronic address:

It's widely acknowledged that, as a neurodegenerative aging disease representing an intermediate stage between cognitive intactness and Alzheimer's disease(AD), Mild cognitive impairment(MCI) poses an excessive burden on patients' well-being, family members, health-care providers as well as the whole society. This study focuses on three cognitive interventions referred from Clare and Woods, that is, Cognitive stimulation(CS), Cognitive training(CT) and Cognitive rehabilitation(CR). Our Network meta-analysis(NMA) is aimed at comparing them with each other for evaluating the optimal cognitive intervention to help elderly adults with MCI to improve their cognitive function. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.009DOI Listing
January 2019
4 Reads

Tauopathy: A common mechanism for neurodegeneration and brain aging.

Mech Ageing Dev 2019 Mar 19;178:72-79. Epub 2019 Jan 19.

Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Scaife Hall, Pittsburgh, 15213, United States. Electronic address:

Tau, a microtubule-associated protein promotes assembly and stability of microtubules which is related to axoplasmic flow and critical neuronal activities upon physiological conditions. Under neurodegenerative condition such as in Alzheimer's Disease (AD), tau-microtubule binding dynamics and equilibrium are severely affected due to its aberrant post-translational modifications including acetylation and hyperphosphorylation. This event results in its conformational changes to form neurofibrillary tangles (NFT) after aggregation in the cytosol. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377302PMC

Transitions between frailty states among community-dwelling older people: A systematic review and meta-analysis.

Ageing Res Rev 2019 Jan 16;50:81-88. Epub 2019 Jan 16.

Department of Primary Care and Population Health, University College London, London, UK.

Frailty is a well-established risk factor for adverse health outcomes. However, comparatively little is known about the dynamic nature of frailty and the extent to which it can improve. The purposes of this study were to systematically search for studies examining frailty transitions over time among community-dwelling older people, and to synthesise pooled frailty transitions rates. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.010DOI Listing
January 2019
3 Reads

Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat.

Mech Ageing Dev 2019 Jan 16. Epub 2019 Jan 16.

Institut Armand-Frappier, INRS, 531 Bld des Prairies, Laval, QC, H7V 1B7, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 4L3, Canada. Electronic address:

Caloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modulated in male Sprague-Dawley (SD) rats submitted to a 40% CR from 8 to 19 months of age, by reference to ad libitum-fed (AL) rats at 2 and 19 months of age. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.002DOI Listing
January 2019
1 Read

Glycation interferes with natural killer cell function.

Mech Ageing Dev 2019 Mar 16;178:64-71. Epub 2019 Jan 16.

Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, Hollystr. 1, D-06114, Halle/Saale, Germany.

One hallmark of molecular aging is glycation, better known as formation of so-called advanced glycation end products (AGEs), where reactive carbonyls react with amino-groups of proteins. AGEs accumulate over time and are responsible for various age-dependent diseases and impairments. Two very potent dicarbonyls to generate AGEs are glyoxal (GO) and methylglyoxal (MGO). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374183021
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http://dx.doi.org/10.1016/j.mad.2019.01.006DOI Listing
March 2019
8 Reads

Apolipoprotein E gene in physiological and pathological aging.

Mech Ageing Dev 2019 Mar 15;178:41-45. Epub 2019 Jan 15.

Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy. Electronic address:

Introduction: The genetic background plays a role on longevity. The distribution of the apolipoprotein E gene (APOE) variants (ε2, ε3, ε4) may differ across age groups, especially in the oldest old and despite geographical and ethnic specificities. Since the ε4 variant is associated with Alzheimer's disease (AD), it might represent an opportunity for exploring the relationship of APOE with physiological and pathological aging. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.005DOI Listing
March 2019
1 Read

Resistin: A reappraisal.

Mech Ageing Dev 2019 Mar 14;178:46-63. Epub 2019 Jan 14.

DIMi, Department of Internal Medicine and medical specialties, Viale Benedetto XV, 6, 16132 University of Genoa, Genoa, Italy.

From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.004DOI Listing
March 2019
2 Reads

Transcriptome profiling of human papillary and reticular fibroblasts from adult interfollicular dermis pinpoints the 'tissue skeleton' gene network as a component of skin chrono-ageing.

Mech Ageing Dev 2019 Jan 11. Epub 2019 Jan 11.

Advanced Research, L'Oréal Research and Innovation, 93600 Aulnay-sous-Bois, France.

Interactions between extracellular matrix (ECM) and fibroblasts are essential for maintaining dermis integrity, and are subject to ageing. The ötissue skeleton' network connects ECM to the nucleus and DNA, impacting nuclear shape and gene expression. In a previous Mech Ageing Dev publication, we have presented a transcriptomic study of papillary (Fp) and reticular (Fr) fibroblasts, with a main focus on Fp ageing. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.003DOI Listing
January 2019
5 Reads

Does senescence promote fitness in Caenorhabditis elegans by causing death?

Ageing Res Rev 2019 Jan 9;50:58-71. Epub 2019 Jan 9.

Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK. Electronic address:

A widely appreciated conclusion from evolutionary theory is that senescence (aging) is of no adaptive value to the individual that it afflicts. Yet studies of Caenorhabditis elegans and Saccharomyces cerevisiae are increasingly revealing the presence of processes which actively cause senescence and death, leading some biogerontologists to wonder about the established theory. Here we argue that programmed death that increases fitness could occur in C. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.008DOI Listing
January 2019
1 Read

Effect of soluble cleavage products of important receptors/ligands on efferocytosis: Their role in inflammatory, autoimmune and cardiovascular disease.

Ageing Res Rev 2019 Jan 9;50:43-57. Epub 2019 Jan 9.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Efferocytosis, the clearance of apoptotic cells (ACs), is a physiologic, multifaceted and dynamic process and a fundamental mechanism for the preservation of tissue homeostasis by avoiding unwanted inflammation and autoimmune responses through special phagocytic receptors. Defective efferocytosis is associated with several disease states, including cardiovascular disease and impaired immune surveillance, as occurs in cancer and autoimmune disease. A major cause of defective efferocytosis is non-functionality of surface receptors on either the phagocytic cells or the ACs, such as TAM family tyrosine kinase, which turns to a soluble form by cleavage/shedding or alternative splicing. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.007DOI Listing
January 2019
1 Read
4.940 Impact Factor

Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis.

Mech Ageing Dev 2019 Mar 10;178:33-40. Epub 2019 Jan 10.

Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address:

Klotho gene polymorphisms have been implicated in healthy aging, but inconsistences in findings from previous case-control studies have raised concerns regarding the associations between KLOTHO gene polymorphisms and susceptibility to aging-related diseases and longevity. Hence, this meta-analysis was performed. We assessed the associations between two polymorphisms (G-395 A/rs1207568 and F352 V/rs9536314) and five parameters (urolithiasis, cognitive impairment, cardiovascular disease, cancer, and longevity) by calculating pooled odds ratios with 95% confidence intervals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374183021
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http://dx.doi.org/10.1016/j.mad.2018.12.003DOI Listing
March 2019
8 Reads
3.397 Impact Factor

Survival time and differences between dementia with Lewy bodies and Alzheimer's disease following diagnosis: A meta-analysis of longitudinal studies.

Ageing Res Rev 2019 Jan 6;50:72-80. Epub 2019 Jan 6.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy; Azienda Zero, Veneto Region, Venice, Italy.

Objective: To synthesize the evidence across longitudinal studies comparing survival in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD).

Methods: We conducted a systematic review and meta-analysis of studies comparing survival in clinically diagnosed DLB to AD. Longitudinal cohort studies were identified through a systematic search of major electronic databases from inception to May 2018. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.005DOI Listing
January 2019
4 Reads
4.940 Impact Factor

The telomere world and aging: Analytical challenges and future perspectives.

Ageing Res Rev 2019 Jan 4;50:27-42. Epub 2019 Jan 4.

Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy. Electronic address:

Telomeres, the terminal nucleoprotein structures of eukaryotic chromosomes, play pleiotropic functions in cellular and organismal aging. Telomere length (TL) varies throughout life due to the influence of genetic factors and to a complex balancing between "shortening" and "elongation" signals. Telomerase, the only enzyme that can elongate a telomeric DNA chain, and telomeric repeat-containing RNA (TERRA), a long non-coding RNA involved in looping maintenance, play key roles in TL during life. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.004DOI Listing
January 2019
1 Read

Exploring the relationship between physical activity, beta-amyloid and tau: A narrative review.

Ageing Res Rev 2019 Jan 4;50:9-18. Epub 2019 Jan 4.

Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; Ageing, Cognition and Exercise Research Group, School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Several prospective cohort studies have reported an association between higher levels of physical activity and decreased risk of cognitive decline and dementia, years later. To support physical activity as a preventative measure against dementia, including Alzheimer's disease (AD; the most common form of dementia), evidence regarding the underlying mechanisms is vital. Here, we review previous work examining the role of physical activity in modulating levels of AD pathological hallmarks, beta-amyloid (Aβ) and tau (in the brain, cerebrospinal fluid and blood). Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.003DOI Listing
January 2019
1 Read

Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells.

Mech Ageing Dev 2019 Mar 4;178:25-32. Epub 2019 Jan 4.

Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, 236-0027, Japan; Ichiban Life Corporation, 1-1-7 Horai-cho, Naka-ku, Yokohama, 231-0048, Japan.

Cellular senescence is a phenomenon of irreversible growth arrest in mammalian somatic cells in culture. Various stresses induce cellular senescence and indeed, we have found that excess thymidine effectively induces cellular senescence in human cells. Further, many reports indicate the implication of chromatin proteins in cellular senescence. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.001DOI Listing
March 2019
1 Read

Emerging roles of long non-coding RNAs in the pathogenesis of Alzheimer's disease.

Ageing Res Rev 2019 Jan 2;50:19-26. Epub 2019 Jan 2.

School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. Electronic address:

Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder and represents the most common form of senile dementia. The pathogenesis of AD is not yet completely understood and no curative treatment is currently available. With the recent advancement in transcriptome-wide profiling approach, several non-coding RNAs (ncRNAs) have been identified. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.001DOI Listing
January 2019
1 Read

Neuroinflammation in mild cognitive impairment and Alzheimer's disease: A meta-analysis.

Ageing Res Rev 2019 Jan 2;50:1-8. Epub 2019 Jan 2.

Department of Psychology, Manchester Metropolitan University, Manchester, United Kingdom.

Background: Increasingly, evidence from brain imaging supports the role of neuroinflammation in dementia progression. Yet, it is not clear if there are patterns of spatial and temporal susceptibility to neuroinflammatory processes in the brain that may correspond to dementia staging or symptom expression.

Methods: We searched literature databases for case-control studies examining levels of translocator protein (TSPO) levels using positron emission tomography, representing neuroinflammation, in regional analyses between healthy controls and mild cognitive impairment (MCI) or Alzheimer's disease (AD) subjects. Read More

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http://dx.doi.org/10.1016/j.arr.2019.01.002DOI Listing
January 2019
6 Reads

Where ageing goes nowadays: Mechanisms, pathways, biomarkers and anti-ageing strategies.

Mech Ageing Dev 2019 01 18;177:1-3. Epub 2018 Dec 18.

Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00476374183025
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http://dx.doi.org/10.1016/j.mad.2018.12.002DOI Listing
January 2019
7 Reads
3.397 Impact Factor

Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview.

Mech Ageing Dev 2019 Mar 7;178:9-15. Epub 2018 Dec 7.

Department of Orthopedics, Augusta University, Augusta, GA, United States; Institute of Regenerative and Reparative medicine, Augusta University, Augusta, GA, United States. Electronic address:

MicroRNA's are small non-coding RNAs that regulate the expression of genes by targeting the 3' UTR's of mRNA. Studies reveal that miRNAs play a pivotal role in normal musculoskeletal function such as mesenchymal stem cell differentiation, survivability and apoptosis, osteogenesis, and chondrogenesis. Changes in normal miRNA expression have been linked to a number of pathological disease processes. Read More

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http://dx.doi.org/10.1016/j.mad.2018.12.001DOI Listing
March 2019
2 Reads

Targeting the proteostasis network in Huntington's disease.

Ageing Res Rev 2019 Jan 28;49:92-103. Epub 2018 Nov 28.

REQUIMTE/LAQV, Department of Drug Sciences, Pharmacology Lab, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal; Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, WC1E 6BT, London, UK. Electronic address:

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion mutation in the huntingtin protein. Expansions above 40 polyglutamine repeats are invariably fatal, following a symptomatic period characterised by choreiform movements, behavioural abnormalities, and cognitive decline. While mutant huntingtin (mHtt) is widely expressed from early life, most patients with HD present in mid-adulthood, highlighting the role of ageing in disease pathogenesis. Read More

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http://dx.doi.org/10.1016/j.arr.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320389PMC
January 2019
1 Read

Reversibility of irreversible aging.

Ageing Res Rev 2019 Jan 1;49:104-114. Epub 2018 Dec 1.

Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119234, Russia; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Most multicellular organisms are known to age, due to accumulation of damage and other deleterious changes over time. These changes are often irreversible, as organisms, humans included, evolved fully differentiated, irreplaceable cells (e.g. Read More

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http://dx.doi.org/10.1016/j.arr.2018.11.008DOI Listing
January 2019
2 Reads

Circular RNA involvement in aging: An emerging player with great potential.

Mech Ageing Dev 2019 Mar 1;178:16-24. Epub 2018 Dec 1.

Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address:

Circular RNA (circRNA) is a class of newly discovered noncoding RNA (ncRNA), presenting as a special covalent loop without a 5' cap or 3' tail. Multiple biological properties of circRNA have been revealed during the past decades, such as widespread expression, high conservation, cell-specificity, tissue-specificity and developmental stage-specific expression patterns, as well as resistance to RNase R digestion. CircRNA also exhibits diverse biological functions, including regulation of host genes, alternative splicing, miRNA sponges, protein traps and even protein synthesis. Read More

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http://dx.doi.org/10.1016/j.mad.2018.11.002DOI Listing
March 2019
11 Reads

The amyloid precursor protein (APP) processing as a biological link between Alzheimer's disease and cancer.

Ageing Res Rev 2019 Jan 27;49:83-91. Epub 2018 Nov 27.

Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

Aging is a risk factor for several illnesses, such as Alzheimer's Disease and various cancers. However, an inverse correlation between malignancies and Alzheimer's Disease has been suggested. This review addressed the potential role of non-amyloidogenic and amyloidogenic pathways of amyloid precursor protein processing as a relevant biochemical mechanism to clarify this association. Read More

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http://dx.doi.org/10.1016/j.arr.2018.11.007DOI Listing
January 2019
7 Reads

MicroRNAs and mild cognitive impairment: A systematic review.

Ageing Res Rev 2018 Nov 22. Epub 2018 Nov 22.

Department of Neurorehabilitation Sciences, Casa Cura Policlinico, Via Dezza 48, 20144, Milano, Italy.

Background: Mild cognitive impairment (MCI) is usually described as an intermediate phase between normal cognition and dementia. Identifying the subjects at a higher risk of progressing from MCI to AD is essential to manage this condition. The diagnosis of MCI is mainly clinical. Read More

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http://dx.doi.org/10.1016/j.arr.2018.11.005DOI Listing
November 2018
18 Reads

Artificial intelligence for aging and longevity research: Recent advances and perspectives.

Ageing Res Rev 2019 Jan 22;49:49-66. Epub 2018 Nov 22.

Pharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Baltimore, MD, United States.

The applications of modern artificial intelligence (AI) algorithms within the field of aging research offer tremendous opportunities. Aging is an almost universal unifying feature possessed by all living organisms, tissues, and cells. Modern deep learning techniques used to develop age predictors offer new possibilities for formerly incompatible dynamic and static data types. Read More

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http://dx.doi.org/10.1016/j.arr.2018.11.003DOI Listing
January 2019
1 Read

MRI-based evaluation of structural degeneration in the ageing brain: Pathophysiology and assessment.

Ageing Res Rev 2019 Jan 22;49:67-82. Epub 2018 Nov 22.

ImageTech Laboratory, Health Sciences and Innovation, Surrey Memorial Hospital, Surrey, British Columbia, Canada; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada; Health Sciences and Innovation, Surrey Memorial Hospital, Surrey, British Columbia, Canada. Electronic address:

Advances in MRI technology have significantly contributed to our ability to understand the process of brain ageing, allowing us to track and assess changes that occur during normal ageing and neurological conditions. This paper focuses on reviewing structural changes of the ageing brain that are commonly seen using MRI, summarizing the pathophysiology, prevalence, and neuroanatomical distribution of changes including atrophy, lacunes, white matter lesions, and dilated perivascular spaces. We also review the clinically accessible methodology for assessing these MRI-based changes, covering visual rating scales, as well computer-aided and fully automated methods. Read More

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January 2019
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RETRACTED: Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing.

Mech Ageing Dev 2019 Mar 22;178:1-8. Epub 2018 Nov 22.

Department of General Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, No. 301 Yanchangzhong Road, Shanghai 200072, China.

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http://dx.doi.org/10.1016/j.mad.2018.11.001DOI Listing
March 2019
7 Reads

Age-related diseases as vicious cycles.

Ageing Res Rev 2019 Jan 17;49:11-26. Epub 2018 Nov 17.

Laboratory of Innovative Medicine, School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Institutsky per., 9, 141701 Dolgoprudny, Moscow Region, Russia. Electronic address:

The mortality rates of age-related diseases (ARDs) increase exponentially with age. Processes described by the exponential growth function typically involve a branching chain reaction or, more generally, a positive feedback loop. Here I propose that each ARD is mediated by one or several positive feedback loops (vicious cycles). Read More

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http://dx.doi.org/10.1016/j.arr.2018.11.002DOI Listing
January 2019
7 Reads
4.940 Impact Factor

The potential nutrigeroprotective role of Mediterranean diet and its functional components on telomere length dynamics.

Ageing Res Rev 2019 Jan 15;49:1-10. Epub 2018 Nov 15.

Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, 86100, Italy. Electronic address:

The Mediterranean diet (MD) is a gold standard for nutrition and the most evidence-based diet to delay the onset of age-associated pathologies. Telomeres are the heterochromatic repeat regions found at the ends of eukaryotic chromosomes, whose length is considered a reliable hallmark of biological ageing. Telomere shortening is, at least in part, a modifiable factor and there is evidence that adherence to the MD is associated with longer telomeres. Read More

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January 2019
10 Reads

Caloric restriction and cellular senescence.

Mech Ageing Dev 2018 12 3;176:19-23. Epub 2018 Nov 3.

University of Groningen, European Research Institute for the Biology of Aging, University Medical Center Groningen, Groningen, Netherlands. Electronic address:

Cellular senescence is a state of irreversible growth arrest characterized by hypertrophy and secretion of various bioactive molecules, a phenomenon defined the Senescence-Associated Secretory Phenotype (SASP). Senescent cells are implicated in a number of biological functions, from embryogenesis to aging. Significantly, excessive accumulation of senescent cells is associated to a decline of regenerative capacity and chronic inflammation. Read More

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http://dx.doi.org/10.1016/j.mad.2018.10.005DOI Listing
December 2018
11 Reads

Orthostatic hypotension and physical functioning in older adults: A systematic review and meta-analysis.

Ageing Res Rev 2018 Dec 28;48:122-144. Epub 2018 Oct 28.

Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Van der Boechorstraat 9, 1081 BT, Amsterdam, The Netherlands; Department of Medicine and Aged Care, @AgeMelbourne, The University of Melbourne, The Royal Melbourne Hospital, City Campus, Level 6 North, 300 Grattan Street, Parkville, Victoria 3050, Australia. Electronic address:

Background: Orthostatic hypotension (OH) may negatively affect physical functioning and aggravate morbidities, but existing evidence is contradictory.

Methods: MEDLINE (from 1946), PubMed (from 1966) and EMBASE databases (from 1947) were systematically searched for studies on the association of OH and physical functioning in older adults, categorized as: balance, gait characteristics, walking speed, Timed Up and Go time, handgrip strength (HGS), physical frailty, exercise tolerance, physical activity, activities of daily living (ADL), and performance on the Hoehn and Yahr scale (HY) and Unified Parkinson's Disease Rating Scale (UPDRS). Study quality was assessed using the Newcastle Ottawa Scale. Read More

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http://dx.doi.org/10.1016/j.arr.2018.10.007DOI Listing
December 2018
21 Reads

Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project.

Ageing Res Rev 2019 Jan 2;49:27-48. Epub 2018 Nov 2.

Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.

Introduction: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts.

Methods: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Read More

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http://dx.doi.org/10.1016/j.arr.2018.10.011DOI Listing
January 2019
9 Reads

Homocysteine and age-associated disorders.

Ageing Res Rev 2019 Jan 2;49:144-164. Epub 2018 Nov 2.

Frontiers in Bioscience Research Institute in Aging and Cancer, Irvine, CA, USA. Electronic address:

There are numerous theories of aging, a process which still seems inevitable. Aging leads to cancer and multi-systemic disorders as well as chronic diseases. Decline in age- associated cellular functions leads to neurodegeneration and cognitive decline that affect the quality of life. Read More

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http://dx.doi.org/10.1016/j.arr.2018.10.010DOI Listing
January 2019
15 Reads

microRNA diagnostic panel for Alzheimer's disease and epigenetic trade-off between neurodegeneration and cancer.

Ageing Res Rev 2019 Jan 2;49:125-143. Epub 2018 Nov 2.

Laboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur 3, 02-093, Warsaw, Poland. Electronic address:

microRNAs (miRNAs) have been extensively studied as potential biomarkers for Alzheimer's disease (AD). Their profiles have been analyzed in blood, cerebrospinal fluid (CSF) and brain tissue. However, due to the high variability between the reported data, stemming from the lack of methodological standardization and the heterogeneity of AD, the most promising miRNA biomarker candidates have not been selected. Read More

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http://dx.doi.org/10.1016/j.arr.2018.10.008DOI Listing
January 2019
8 Reads

Association between human herpes virus seropositivity and frailty in the elderly: A systematic review and meta-analysis.

Ageing Res Rev 2018 Dec 1;48:145-152. Epub 2018 Nov 1.

Investigative Pathology Laboratory, Federal University of Sergipe, Brazil. Electronic address:

Frailty is an emerging geriatric syndrome characterized by decreased physiologic reserve and increased vulnerability to environmental factors. Several studies have examined the association between persistent cytomegalovirus (CMV) infection and poor clinical outcomes in the elderly, but the results are often contradictory. Here, we performed a systematic review and meta-analysis to analyze the association between human herpesvirus seropositivity [CMV, Epstein-Barr virus (EBV), Varicella zoster virus (VZV), and Herpes simplex virus (HSV)] and frailty in elderly people. Read More

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December 2018
4 Reads

Methionine restriction leads to hyperhomocysteinemia and alters hepatic HS production capacity in Fischer-344 rats.

Mech Ageing Dev 2018 12 25;176:9-18. Epub 2018 Oct 25.

Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada; Centre on Aging, University of Manitoba, Winnipeg, MB, Canada. Electronic address:

Dietary methionine restriction (MR) increases lifespan in several animal models. Despite low dietary intake of sulphur amino acids, rodents on MR develop hyperhomocysteinemia. On the contrary, MR has been reported to increase HS production in mice. Read More

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http://dx.doi.org/10.1016/j.mad.2018.10.004DOI Listing
December 2018
13 Reads

Overview of oral antithrombotic treatment in elderly patients with atrial fibrillation.

Ageing Res Rev 2019 Jan 22;49:115-124. Epub 2018 Oct 22.

TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road, 7th floor, Suite 7022, Boston, MA, 02115, USA. Electronic address:

Atrial fibrillation (AF) is an age-related arrhythmia, particularly affecting elderly patients. The ultimate goals in the treatment of AF are to improve prognosis and quality of life. Anticoagulants are effective for stroke prevention in AF patients, however, managing anticoagulation in elderly patients is especially challenging; requiring a comprehensive assessment of the patient and deep understanding of available therapies and doses to maximize the net benefit. Read More

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http://dx.doi.org/10.1016/j.arr.2018.10.006DOI Listing
January 2019
17 Reads

Genetic modifiers of age-at-onset in polyglutamine diseases.

Ageing Res Rev 2018 Dec 21;48:99-108. Epub 2018 Oct 21.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, PR China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, PR China; Xinjiang Medical University, Xinjiang, 830011, PR China. Electronic address:

Polyglutamine (polyQ) diseases are a group of clinically and genetically heterogeneous neurodegenerative diseases. Expansion size correlates with age-at-onset (AO) and severity, and shows a critical threshold for each polyQ disease. Although an expanded CAG tract is sufficient to trigger disease, not all variation in AO is explained by (CAG) length, which suggests the contribution of other modifying factors. Read More

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December 2018
12 Reads
4.940 Impact Factor

Postmenopausal health interventions: Time to move on from the Women's Health Initiative?

Ageing Res Rev 2018 Dec 21;48:79-86. Epub 2018 Oct 21.

Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, 2308, Australia; University of Southern Queensland, Institute for Resilient Regions, Springfield Central, Queensland, 4300, Australia. Electronic address:

Menopause is a critical period during which, without timely interventions, increased risks of cardiovascular and metabolic diseases, osteoporosis, sexual dysfunction and premature cognitive decline will contribute to diminished quality-of-life in women. Hormone therapy (HT) used to be the standard of care for managing vasomotor symptoms and prevention of chronic diseases until publication of the Women's Health Initiative (WHI) in 2002. Concerned about risks highlighted in WHI publications, many symptomatic women promptly ceased HT which resulted in increased vasomotor symptoms, osteoporosis-related-fractures and insomnia. Read More

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December 2018
9 Reads

Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing.

Ageing Res Rev 2018 Dec 15;48:87-98. Epub 2018 Oct 15.

IRCCS MultiMedica, Milan, Italy; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.

Metformin is the first-choice therapy to lower glycaemia and manage type 2 diabetes. Continuously emerging epidemiological data and experimental models are showing additional protective effects of metformin against a number of age-related diseases (ARDs), e.g. Read More

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http://dx.doi.org/10.1016/j.arr.2018.10.003DOI Listing
December 2018
8 Reads