5,632 results match your criteria Ageing Research Reviews [Journal]


Primary cilium and brain aging: role in neural stem cells, neurodegenerative diseases and glioblastoma.

Ageing Res Rev 2019 Apr 17. Epub 2019 Apr 17.

Cellular Oncology group, Biodonostia Health Research Institute, San Sebastian, Spain; CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes), Madrid, Spain; IKERBASQUE, Basque Foundation, Bilbao, Spain. Electronic address:

Brain aging is characterized by a progressive loss of tissue integrity and function as a consequence of impaired homeostasis and regeneration capacities. The primary cilium is a highly conserved organelle that projects from the cell surface in a single copy in virtually all mammalian cell types including neural stem/progenitors cells and neurons. Increasing evidence in the last decade points out that primary cilium could be a relevant mediator of neural stem cell activity, neurogenesis, neuronal maturation and maintenance, and brain tumorigenesis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15681637183030
Publisher Site
http://dx.doi.org/10.1016/j.arr.2019.04.004DOI Listing
April 2019
1 Read

Oxidative stress-induced senescence markedly increases disc cell bioenergetics.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

Cellular senescence is a phenotype characterized by irreversible growth arrest, chronic elevated secretion of proinflammatory cytokines and matrix proteases, a phenomenon known as senescence associated secretory phenotype (SASP). Biomarkers of cellular senescence have been shown to increase with age and degeneration of human disc tissue. Senescent disc cells in culture recapitulate features associated with age-related disc degeneration, including increased secretion of proinflammatory cytokines, matrix proteases, and fragmentation of matrix proteins. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374183019
Publisher Site
http://dx.doi.org/10.1016/j.mad.2019.04.006DOI Listing
April 2019
1 Read

Frailty biomarkers in humans and rodents: current approaches and future advances.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Department of Pharmacology, The University of New South Wales, Sydney, Australia. Electronic address:

Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are limitations to the current state of the research. Future approaches to the identification of frailty biomarkers should include longitudinal studies, studies using animal models of frailty, studies incorporating novel biomarkers combined into composite panels, and studies investigating sex differences and potential overlap between markers of biological age and frailty. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374193003
Publisher Site
http://dx.doi.org/10.1016/j.mad.2019.03.007DOI Listing
April 2019
1 Read

AGE-RELATED DEFICIT ACCUMULATION AND THE DISEASES OF AGEING.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.

With ageing, the potency of individual risk factors traditionally associated with common illnesses declines. Instead, it is becoming clear that the impact of a wide range of age-related deficits not traditionally considered as risk factors for these illnesses increases. These age-related deficits chiefly confer risk as a group, not individually. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374193001
Publisher Site
http://dx.doi.org/10.1016/j.mad.2019.04.005DOI Listing
April 2019
1 Read

The impact of behavioral interventions on cognitive function in healthy older adults: A systematic review.

Authors:
Briana N Sprague

Ageing Res Rev 2019 Apr 16. Epub 2019 Apr 16.

The Pennsylvania State University, 119 Health and Human Development Building, University Park 16802, US. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.04.002DOI Listing

Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson's disease.

Mech Ageing Dev 2019 Apr 15;180:89-96. Epub 2019 Apr 15.

Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou, Zhejiang, China; Department of Preventive Medicine, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Selenium (Se), an essential trace mineral, confers its physiological functions mainly through selenoproteins, most of which are oxidoreductases. Results from animal, epidemiological, and human genetic studies link Parkinson's disease to Se and certain selenoproteins. Parkinson's disease is characterized by multiple motor and non-motor symptoms that are difficult to diagnose at early stages of the pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.04.004DOI Listing
April 2019
2 Reads

Modulation of frailty syndrome by diet: A review of evidence from mouse studies.

Mech Ageing Dev 2019 Apr 10;180:82-88. Epub 2019 Apr 10.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA.

Frailty is a progressive, aging-related syndrome of unknown etiology characterized by increased susceptibility and decreased resilience to external stressors. Understanding underlying mechanisms and identifying interventions to improve resilience are major challenges in biogerontology. Adequate nutrition is central to organismal health and wellbeing and can be modulated to improve longevity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374193004
Publisher Site
http://dx.doi.org/10.1016/j.mad.2019.04.003DOI Listing
April 2019
3 Reads

Astragaloside IV and ferulic acid synergistically promote neurite outgrowth through Nrf2 activation.

Mech Ageing Dev 2019 Apr 10;180:70-81. Epub 2019 Apr 10.

The Institute of Medicine, Qiqihar Medical University, Qiqihar 161006, China. Electronic address:

Recently, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) have nuclear localization and nuclear exclusion signals and shuttle between the cytoplasm and the nucleus. Thus, we hypothesised that astragaloside IV (AS-IV) induction nuclear import of Nrf2 and ferulic acid (FA) inhibition nuclear export of Nrf2 contribute to synergistic antioxidant effects of combination of FA and AS-IV (FA/AS-IV). Here, we have demonstrated that FA/AS-IV enhances neurite outgrowth of PC12 cells challenged with lead acetate (PbAc) via antioxidant properties in a synergistic manner. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374193000
Publisher Site
http://dx.doi.org/10.1016/j.mad.2019.04.002DOI Listing
April 2019
2 Reads

LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging.

Ageing Res Rev 2019 Apr 4;52:17-31. Epub 2019 Apr 4.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China. Electronic address:

Fibrosis is universally observed in multiple aging-related diseases and progressions and is characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various human organs and eventually results in organ failure. Noncoding RNAs (ncRNAs) have emerged as essential regulators of cellular signaling and relevant human diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.04.001DOI Listing
April 2019
2 Reads

Sublethal whole-body irradiation causes progressive premature frailty in mice.

Mech Ageing Dev 2019 Apr 4;180:63-69. Epub 2019 Apr 4.

Newcastle University Institute for Ageing and Institute for Cell and Molecular Biology, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne, NE4 5PL, UK. Electronic address:

There is an unmet need to develop and validate therapies that can treat or at least prevent premature therapy-induced frailty, multi-morbidity and mortality in long-term tumour survivors. In an approach to develop a first mouse model for therapy-induced long-term frailty, we irradiated male C57Bl/6 mice at 5-6 months of age sub-lethally with 3 × 3 Gy (whole body) and assessed subsequent frailty for up to 6 months using a Rockwood-type frailty index (FI). Frailty scorers were trained to obtain excellent inter- and intra-observer reproducibility. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374193001
Publisher Site
http://dx.doi.org/10.1016/j.mad.2019.03.006DOI Listing
April 2019
4 Reads

High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools.

Mech Ageing Dev 2019 Apr 2;180:49-62. Epub 2019 Apr 2.

Division of Geriatrics and Palliative Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo and Research Service, Veterans Affairs Western New York Healthcare System, Buffalo, NY, USA.

Frailty syndrome increases the risk for disability and mortality, and is a major health concern amidst the geriatric shift in the population. High intensity interval training (HIIT), which couples bursts of vigorous activity interspersed with active recovery intervals, shows promise for the treatment of frailty. Here we compare and contrast five Fried physical phenotype and one deficit accumulation based mouse frailty assessment tools for identifying the impacts of HIIT on frailty and predicting functional capacity, underlying pathology, and survival in aged female mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.04.001DOI Listing
April 2019
1 Read

Frailty for predicting all-cause mortality in elderly acute coronary syndrome patients: A meta-analysis.

Ageing Res Rev 2019 Mar 28;52:1-6. Epub 2019 Mar 28.

Institute of Molecular Biology & Translational Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu, 212002, China. Electronic address:

Background: Frailty has been identified as a risk factor for mortality in patients with acute coronary syndrome (ACS). This meta-analysis aimed to evaluate the association between frailty and all-cause mortality outcome in patients with ACS.

Methods: Pubmed and Embase databases were searched up to September 26, 2018 for the observational studies evaluating the association between frailty and all-cause mortality in elderly ACS patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.03.003DOI Listing
March 2019
1 Read

Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions.

Mech Ageing Dev 2019 Mar 26;180:42-48. Epub 2019 Mar 26.

Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

Although survival has been the focus of aging research for many years, the field is rapidly evolving towards incorporating healthspan and health indices in studies that explore aging-related outcomes. Frailty is one such measure that is tightly correlated with human aging. Several frailty measures have been developed that focus on phenotypes of aging, including physical, cognitive and metabolic health that define healthspan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.03.005DOI Listing
March 2019
3 Reads

The impact of physical activity and sedentary behaviors on frailty levels.

Mech Ageing Dev 2019 Mar 26;180:29-41. Epub 2019 Mar 26.

Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Heterogeneity in aging can be explained by frailty. Lifestyle behaviors such as physical activity can help manage frailty levels. Conversely, sedentary behaviours are associated with frailty independently of physical activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.03.004DOI Listing

Does loneliness contribute to mild cognitive impairment and dementia? A systematic review and meta-analysis of longitudinal studies.

Ageing Res Rev 2019 Mar 23;52:7-16. Epub 2019 Mar 23.

Department of Psychiatry, Universidad Autónoma de Madrid, Spain; Department of Psychiatry, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Madrid, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental. CIBERSAM, Spain.

There is growing evidence that loneliness is associated with mild cognitive impairment (MCI) and dementia. However, the extent of this association remains unclear. A systematic review and meta-analysis of longitudinal studies examining this association was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.03.002DOI Listing
March 2019
2 Reads

Age and frailty as risk factors for the development of osteoarthritis.

Mech Ageing Dev 2019 Mar 18;180:21-28. Epub 2019 Mar 18.

Departments of Pharmacology and Anaesthesia, Pain Management & Perioperative Medicine, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, B3H 4R2, Canada. Electronic address:

Osteoarthritis (OA) is a degenerative joint disease that increases in prevalence with advanced age. While a multitude of factors contribute to the development of OA, ageing has been implicated as a major driving force leading to an inability of the joint to repair itself and maintain normal health. In aged individuals, changes in joint cellular composition and signalling mechanisms have been observed which could lead to the development of degenerative joint disease. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374193000
Publisher Site
http://dx.doi.org/10.1016/j.mad.2019.03.003DOI Listing
March 2019
3 Reads

Geroprotectors: A role in the treatment of frailty.

Mech Ageing Dev 2019 Mar 15;180:11-20. Epub 2019 Mar 15.

MRC Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing, University of Sheffield, UK. Electronic address:

The proportion of the population over the age of 65 is growing the most rapidly due to the longevity revolution. Frailty is prevalent in this age group and strongly associated with disability and hospitalization, having a significant impact on the costs of health and social care. New effective interventions to delay or reverse frailty are urgently required. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.03.002DOI Listing

Circulating miR-146a in healthy aging and type 2 diabetes: Age- and gender-specific trajectories.

Mech Ageing Dev 2019 Mar 14;180:1-10. Epub 2019 Mar 14.

Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.

To evaluate the combined effect of age and glycemic state on circulating levels of the inflamma-miR-146a levels, 188 healthy subjects (CTR) aged 20-104 years and 144 type-2 diabetic patients (T2DM), aged 40-80 years, were analyzed. In CTR subjects, miR-146a levels showed a significant age-related decline. When a gender-stratified analysis was ran, the miR-146a age-related trajectory was confirmed only in men and a negative correlation with PAI-1, uric acid, and creatinine was also observed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.03.001DOI Listing
March 2019
2 Reads

Where are we now in relation to determining the prevalence of ageism in this era of escalating population ageing?

Ageing Res Rev 2019 May 9;51:78-84. Epub 2019 Mar 9.

Faculty of Nursing, University of Alberta, Third Floor ECHA Building, Edmonton, T6G1C9, Canada. Electronic address:

Population ageing is escalating rapidly now worldwide. This is an important time to determine if ageism or discrimination against older people is of concern, such as it being prevalent and/or increasing in prevalence. Over the years, many ageism measurement tools have been developed, with research findings from their use of prime consideration then for determining the prevalence of ageism and any prevalence trends. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15681637183031
Publisher Site
http://dx.doi.org/10.1016/j.arr.2019.03.001DOI Listing
May 2019
13 Reads

Hyperhomocysteinemia and risk of incident cognitive outcomes: An updated dose-response meta-analysis of prospective cohort studies.

Ageing Res Rev 2019 May 28;51:55-66. Epub 2019 Feb 28.

College of Medicine & Health, Lishui University, Lishui City, Zhejiang Province, 323000, China.

Objective: This study aimed to comprehensively assess the dose-response relationship between blood homocysteine levels and risk of all cause, Alzheimer and vascular dementia, as well as cognitive impairment without dementia (CIND).

Method: We searched for all related prospective cohort studies reporting homocysteine as an exposure from patients with cognitive disorders as a result in the PubMed and EMBASE databases up to June 18, 2018. Pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) were extracted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.02.006DOI Listing
May 2019
1 Read

Effect of nutritional supplementations on physical performance and muscle strength parameters in older people: A systematic review and meta-analysis.

Ageing Res Rev 2019 May 28;51:48-54. Epub 2019 Feb 28.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy.

Malnutrition plays a role in the development of poor physical performance, frailty and sarcopenia. The use of nutritional supplementations for improving physical performance and muscle strength parameters in older people is unclear. We therefore aimed to summarize the effect of nutritional supplementations compared to placebo on physical performance (i. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15681637183034
Publisher Site
http://dx.doi.org/10.1016/j.arr.2019.02.005DOI Listing
May 2019
4 Reads
4.940 Impact Factor

Do sex differences in chronic disease underpin the sex-frailty paradox?

Mech Ageing Dev 2019 04 27;179:44-50. Epub 2019 Feb 27.

Centre for Health Services Research, Level 2, Building 33, Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba, QLD, 4102, Australia.

The 'male-female health-survival paradox' is a well-described clinical phenomenon. More recently, it has been conceptualized as a 'sex-frailty paradox': females may be considered to be more frail (because they have poorer health status) but also less frail (because they are less vulnerable to death) than males of the same age. Here, we review potential biological, behavioral and social mechanisms underpinning sex differences in morbidity, mortality and frailty before considering the question at the center of the sex paradox - why is it that females are able to tolerate poor health better than males? We explore, in detail, a frequently cited explanation for the sex paradox that centers on sex differences in chronic disease and conclude by presenting a new approach to this old hypothesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.02.004DOI Listing
April 2019
1 Read

Effects of sustained cognitive activity on white matter microstructure and cognitive outcomes in healthy middle-aged adults: A systematic review.

Ageing Res Rev 2019 May 22;51:35-47. Epub 2019 Feb 22.

Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia. Electronic address:

Adults who remain cognitively active may be protected from age-associated changes in white matter (WM) and cognitive decline. To determine if cognitive activity is a precursor for WM plasticity, the available literature was systematically searched for Region of Interest (ROI) and whole-brain studies assessing the efficacy of cognitive training (CT) on WM microstructure using Diffusion Tensor Imaging (DTI) in healthy adults (> 40 years). Seven studies were identified and included in this review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.02.004DOI Listing
May 2019
2 Reads

Functional genomics of dietary restriction and longevity in yeast.

Mech Ageing Dev 2019 04 18;179:36-43. Epub 2019 Feb 18.

Unidad de Genómica Avanzada (Langebio), Centro de Investigación y de Estudios Avanzados del IPN, 36824, Irapuato, Guanajuato, Mexico. Electronic address:

Dietary restriction-limitation of calories or other specific nutrients in the diet-is the sole non-genetic intervention known to extend the lifespan of a wide range of model organisms from yeast to mammals. Cell biology studies on the responses to dietary restriction have provided important clues about the mechanisms of longevity; however, a comprehensive genome-wide description of lifespan by dietary restriction has been mostly absent. Large-scale genetic analysis in the budding yeast Saccharomyces cerevisiae offers a great opportunity to uncover the conserved systems-level mechanisms that give way to longevity in response to diet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.02.003DOI Listing
April 2019
1 Read

Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.

Ageing Res Rev 2019 May 15;51:1-10. Epub 2019 Feb 15.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy. Electronic address:

The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.02.003DOI Listing
May 2019
2 Reads
4.940 Impact Factor

The peculiar aging of human liver: A geroscience perspective within transplant context.

Ageing Res Rev 2019 May 14;51:24-34. Epub 2019 Feb 14.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; CIG-Interdepartmental Center "Galvani", University of Bologna, Bologna, Italy; CSR-Centro di Studio per la Ricerca dell'Invecchiamento, University of Bologna, Bologna, Italy.

An appraisal of recent data highlighting aspects inspired by the new Geroscience perspective are here discussed. The main findings are summarized as follows: i) liver has to be considered an immunological organ, and new studies suggest a role for the recently described cells named telocytes; ii) the liver-gut axis represents a crucial connection with environment and life style habits and may influence liver diseases onset; iii) the physiological aging of liver shows relatively modest alterations. Nevertheless, several molecular changes appear to be relevant: a) an increase of microRNA-31-5p; -141-3p; -200c-3p expressions after 60 years of age; b) a remodeling of genome-wide DNA methylation profile evident until 60 years of age and then plateauing; c) changes in transcriptome including the metabolic zones of hepatocyte lobules; d) liver undergoes an accelerated aging in presence of chronic inflammation/liver diseases in a sort of continuum, largely as a consequence of unhealthy life styles and exposure to environmental noxious agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.02.002DOI Listing
May 2019
1 Read

The role of DNA methylation and hydroxymethylation in immunosenescence.

Ageing Res Rev 2019 May 12;51:11-23. Epub 2019 Feb 12.

Department of Human Genetics, Emory University, Atlanta, GA, USA; Population Biology, Ecology, and Evolution Program, Emory University, Atlanta, GA, USA.

A healthy functioning immune system is critical to stave off infectious diseases, but as humans and other organisms age, their immune systems decline. As a result, diseases that were readily thwarted in early life pose nontrivial harm and can even be deadly in late life. Immunosenescence is defined as the general deterioration of the immune system with age, and it is characterized by functional changes in hematopoietic stem cells (HSCs) and specific blood cell types as well as changes in levels of numerous factors, particularly those involved in inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.011DOI Listing
May 2019
2 Reads

Retraction notice to "Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing" [YNBDI 178 (2019) 1 - 8].

Mech Ageing Dev 2019 03;178:R1

Department of General Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, No. 301 Yanchangzhong Road, Shanghai 200072, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.02.002DOI Listing

Unravelling protein aggregation as an ageing related process or a neuropathological response.

Ageing Res Rev 2019 May 11;51:67-77. Epub 2019 Feb 11.

Neuroscience and Signalling Laboratory, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal; The Discovery CTR, University of Aveiro Campus, 3810-193 Aveiro, Portugal. Electronic address:

Protein aggregation is normally associated with amyloidosis, namely motor neurone, Alzheimer's, Parkinson's or prion diseases. However, recent results have unveiled a concept of gradual increase of protein aggregation associated with the ageing process, apparently not necessarily associated with pathological conditions. Given that protein aggregation is sufficient to activate stress-response and inflammation, impairing protein synthesis and quality control mechanisms, the former is assumed to negatively affect cellular metabolism and behaviour. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.02.001DOI Listing

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations.

Mech Ageing Dev 2019 04 6;179:23-35. Epub 2019 Feb 6.

Microbial Resources Division, Institute of Bioresources and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal, 795 001, Manipur, India. Electronic address:

Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.02.001DOI Listing
April 2019
2 Reads

Post stroke depression and risk of stroke recurrence and mortality: A systematic review and meta-analysis.

Ageing Res Rev 2019 Mar 31;50:102-109. Epub 2019 Jan 31.

South London and Maudsley NHS Foundation Trust, London, United Kingdom; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Electronic address:

Background: Post stroke depression is a significant neuropsychiatric manifestation, predicting a range of poor outcomes. There are several studies investigating the association between post stroke depression and stroke recurrence/mortality, but results have been inconsistent.

Objective: A systematic review, meta-analysis and meta regression of observational studies assessing the association between post stroke depression and risk of stroke recurrence and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.013DOI Listing
March 2019
2 Reads

Cell cycle arrest in replicative senescence is not an immediate consequence of telomere dysfunction.

Mech Ageing Dev 2019 04 30;179:11-22. Epub 2019 Jan 30.

King's College London, Faculty of Life Sciences & Medicine, Department of Anatomy, Guy's Campus, LONDON SE1 1UL, UK; St George's, University of London, Molecular and Clinical Sciences Research Institute, Mailpoint J2A, Cranmer Terrace, London, SW17 0RE, UK. Electronic address:

In replicative senescence, cells with critically-short telomeres activate a DNA-damage response leading to cell-cycle arrest, while those without telomere dysfunction would be expected to cycle normally. However, population growth declines more gradually than such a simple binary switch between cycling and non-cycling states would predict. We show here that late-passage cultures of human fibroblasts are not a simple mixture of cycling and non-cycling cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.01.009DOI Listing

A systematic literature review and meta-analysis of real-world interventions for cognitive ageing in healthy older adults.

Ageing Res Rev 2019 Mar 29;50:110-130. Epub 2019 Jan 29.

Department of Psychology, Heriot-Watt University, Edinburgh, EH14 4AS, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. Electronic address:

Activities running in community-based-settings offer a method of delivering multimodal interventions to older adults beyond cognitive training programmes. This systematic review and meta-analysis investigated the impact of randomised controlled trials (RCTs) of 'real-world' interventions on the cognitive abilities of healthy older adults. Database searches were performed between October 2016 and September 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.006DOI Listing
March 2019
1 Read

Rodent models of frailty and their application in preclinical research.

Mech Ageing Dev 2019 04 28;179:1-10. Epub 2019 Jan 28.

Department of Pharmacology, Dalhousie University, Halifax, NS, Canada; Department of Medicine (Geriatric Medicine), Dalhousie University, Halifax, NS, Canada. Electronic address:

In clinical medicine, the concept of frailty is viewed as a state of high vulnerability to adverse health outcomes in people of the same age. Frailty is an important challenge because the loss of physiological reserve means that even minor stressors can lead to disability and death in those who are frail. Even so, the biology of frailty is not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.01.008DOI Listing

The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease.

Ageing Res Rev 2019 Mar 25;50:89-101. Epub 2019 Jan 25.

Unité de Traffic Membranaire et Pathogénèse, Institut Pasteur, Paris, France. Electronic address:

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. PD is characterized by the loss of dopaminergic neurons, primarily in brain regions that control motor functions, thereby leading to motor impairments in the patients. Pathological aggregated forms of the synaptic protein, α-synuclein (α-syn), are involved in the generation and progression of PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.012DOI Listing
March 2019
1 Read

The optimal treatment for improving cognitive function in elder people with mild cognitive impairment incorporating Bayesian network meta-analysis and systematic review.

Ageing Res Rev 2019 May 22;51:85-96. Epub 2019 Jan 22.

School of Nursing, Medical College of Soochow University, Suzhou, PR China. Electronic address:

It's widely acknowledged that, as a neurodegenerative aging disease representing an intermediate stage between cognitive intactness and Alzheimer's disease (AD), Mild cognitive impairment (MCI) poses an excessive burden on patients' well-being, family members, health-care providers as well as the whole society. This study focuses on three cognitive interventions proposed by Clare and Woods, which are, Cognitive stimulation (CS), Cognitive training (CT) and Cognitive rehabilitation (CR). Our Network meta-analysis (NMA) aims to compar them with one another to determine the optimal cognitive intervention for elderly adults with MCI in improving their cognitive function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.009DOI Listing
May 2019
21 Reads

Tauopathy: A common mechanism for neurodegeneration and brain aging.

Mech Ageing Dev 2019 03 19;178:72-79. Epub 2019 Jan 19.

Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Scaife Hall, Pittsburgh, 15213, United States. Electronic address:

Tau, a microtubule-associated protein promotes assembly and stability of microtubules which is related to axoplasmic flow and critical neuronal activities upon physiological conditions. Under neurodegenerative condition such as in Alzheimer's Disease (AD), tau-microtubule binding dynamics and equilibrium are severely affected due to its aberrant post-translational modifications including acetylation and hyperphosphorylation. This event results in its conformational changes to form neurofibrillary tangles (NFT) after aggregation in the cytosol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377302PMC

Transitions between frailty states among community-dwelling older people: A systematic review and meta-analysis.

Ageing Res Rev 2019 Mar 16;50:81-88. Epub 2019 Jan 16.

Department of Primary Care and Population Health, University College London, London, UK.

Frailty is a well-established risk factor for adverse health outcomes. However, comparatively little is known about the dynamic nature of frailty and the extent to which it can improve. The purposes of this study were to systematically search for studies examining frailty transitions over time among community-dwelling older people, and to synthesise pooled frailty transitions rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.010DOI Listing
March 2019
3 Reads

Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat.

Mech Ageing Dev 2019 04 16;179:51-59. Epub 2019 Jan 16.

Institut Armand-Frappier, INRS, 531 Bld des Prairies, Laval, QC, H7V 1B7, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 4L3, Canada. Electronic address:

Caloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modulated in male Sprague-Dawley (SD) rats submitted to a 40% CR from 8 to 19 months of age, by reference to ad libitum-fed (AL) rats at 2 and 19 months of age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.01.002DOI Listing
April 2019
1 Read

Glycation interferes with natural killer cell function.

Mech Ageing Dev 2019 03 16;178:64-71. Epub 2019 Jan 16.

Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, Hollystr. 1, D-06114, Halle/Saale, Germany.

One hallmark of molecular aging is glycation, better known as formation of so-called advanced glycation end products (AGEs), where reactive carbonyls react with amino-groups of proteins. AGEs accumulate over time and are responsible for various age-dependent diseases and impairments. Two very potent dicarbonyls to generate AGEs are glyoxal (GO) and methylglyoxal (MGO). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374183021
Publisher Site
http://dx.doi.org/10.1016/j.mad.2019.01.006DOI Listing
March 2019
14 Reads

Apolipoprotein E gene in physiological and pathological aging.

Mech Ageing Dev 2019 03 15;178:41-45. Epub 2019 Jan 15.

Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy. Electronic address:

Introduction: The genetic background plays a role on longevity. The distribution of the apolipoprotein E gene (APOE) variants (ε2, ε3, ε4) may differ across age groups, especially in the oldest old and despite geographical and ethnic specificities. Since the ε4 variant is associated with Alzheimer's disease (AD), it might represent an opportunity for exploring the relationship of APOE with physiological and pathological aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.01.005DOI Listing
March 2019
1 Read

Resistin: A reappraisal.

Mech Ageing Dev 2019 03 14;178:46-63. Epub 2019 Jan 14.

DIMi, Department of Internal Medicine and medical specialties, Viale Benedetto XV, 6, 16132 University of Genoa, Genoa, Italy.

From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.01.004DOI Listing
March 2019
2 Reads

Transcriptome profiling of human papillary and reticular fibroblasts from adult interfollicular dermis pinpoints the 'tissue skeleton' gene network as a component of skin chrono-ageing.

Mech Ageing Dev 2019 04 11;179:60-77. Epub 2019 Jan 11.

Advanced Research, L'Oréal Research and Innovation, 93600 Aulnay-sous-Bois, France.

Interactions between extracellular matrix (ECM) and fibroblasts are essential for maintaining dermis integrity, and are subject to ageing. The ötissue skeleton' network connects ECM to the nucleus and DNA, impacting nuclear shape and gene expression. In a previous Mech Ageing Dev publication, we have presented a transcriptomic study of papillary (Fp) and reticular (Fr) fibroblasts, with a main focus on Fp ageing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.01.003DOI Listing
April 2019
12 Reads

Does senescence promote fitness in Caenorhabditis elegans by causing death?

Ageing Res Rev 2019 Mar 9;50:58-71. Epub 2019 Jan 9.

Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK. Electronic address:

A widely appreciated conclusion from evolutionary theory is that senescence (aging) is of no adaptive value to the individual that it afflicts. Yet studies of Caenorhabditis elegans and Saccharomyces cerevisiae are increasingly revealing the presence of processes which actively cause senescence and death, leading some biogerontologists to wonder about the established theory. Here we argue that programmed death that increases fitness could occur in C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.008DOI Listing
March 2019
1 Read

Effect of soluble cleavage products of important receptors/ligands on efferocytosis: Their role in inflammatory, autoimmune and cardiovascular disease.

Ageing Res Rev 2019 Mar 9;50:43-57. Epub 2019 Jan 9.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Efferocytosis, the clearance of apoptotic cells (ACs), is a physiologic, multifaceted and dynamic process and a fundamental mechanism for the preservation of tissue homeostasis by avoiding unwanted inflammation and autoimmune responses through special phagocytic receptors. Defective efferocytosis is associated with several disease states, including cardiovascular disease and impaired immune surveillance, as occurs in cancer and autoimmune disease. A major cause of defective efferocytosis is non-functionality of surface receptors on either the phagocytic cells or the ACs, such as TAM family tyrosine kinase, which turns to a soluble form by cleavage/shedding or alternative splicing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.007DOI Listing
March 2019
1 Read
4.940 Impact Factor

Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis.

Mech Ageing Dev 2019 03 10;178:33-40. Epub 2019 Jan 10.

Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address:

Klotho gene polymorphisms have been implicated in healthy aging, but inconsistences in findings from previous case-control studies have raised concerns regarding the associations between KLOTHO gene polymorphisms and susceptibility to aging-related diseases and longevity. Hence, this meta-analysis was performed. We assessed the associations between two polymorphisms (G-395 A/rs1207568 and F352 V/rs9536314) and five parameters (urolithiasis, cognitive impairment, cardiovascular disease, cancer, and longevity) by calculating pooled odds ratios with 95% confidence intervals. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374183021
Publisher Site
http://dx.doi.org/10.1016/j.mad.2018.12.003DOI Listing
March 2019
19 Reads
3.397 Impact Factor

Survival time and differences between dementia with Lewy bodies and Alzheimer's disease following diagnosis: A meta-analysis of longitudinal studies.

Ageing Res Rev 2019 Mar 6;50:72-80. Epub 2019 Jan 6.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy; Azienda Zero, Veneto Region, Venice, Italy.

Objective: To synthesize the evidence across longitudinal studies comparing survival in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD).

Methods: We conducted a systematic review and meta-analysis of studies comparing survival in clinically diagnosed DLB to AD. Longitudinal cohort studies were identified through a systematic search of major electronic databases from inception to May 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.005DOI Listing
March 2019
7 Reads
4.940 Impact Factor

The telomere world and aging: Analytical challenges and future perspectives.

Ageing Res Rev 2019 Mar 4;50:27-42. Epub 2019 Jan 4.

Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy. Electronic address:

Telomeres, the terminal nucleoprotein structures of eukaryotic chromosomes, play pleiotropic functions in cellular and organismal aging. Telomere length (TL) varies throughout life due to the influence of genetic factors and to a complex balancing between "shortening" and "elongation" signals. Telomerase, the only enzyme that can elongate a telomeric DNA chain, and telomeric repeat-containing RNA (TERRA), a long non-coding RNA involved in looping maintenance, play key roles in TL during life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.004DOI Listing
March 2019
1 Read

Exploring the relationship between physical activity, beta-amyloid and tau: A narrative review.

Ageing Res Rev 2019 Mar 4;50:9-18. Epub 2019 Jan 4.

Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; Ageing, Cognition and Exercise Research Group, School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Several prospective cohort studies have reported an association between higher levels of physical activity and decreased risk of cognitive decline and dementia, years later. To support physical activity as a preventative measure against dementia, including Alzheimer's disease (AD; the most common form of dementia), evidence regarding the underlying mechanisms is vital. Here, we review previous work examining the role of physical activity in modulating levels of AD pathological hallmarks, beta-amyloid (Aβ) and tau (in the brain, cerebrospinal fluid and blood). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.01.003DOI Listing
March 2019
1 Read

Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells.

Mech Ageing Dev 2019 03 4;178:25-32. Epub 2019 Jan 4.

Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, 236-0027, Japan; Ichiban Life Corporation, 1-1-7 Horai-cho, Naka-ku, Yokohama, 231-0048, Japan.

Cellular senescence is a phenomenon of irreversible growth arrest in mammalian somatic cells in culture. Various stresses induce cellular senescence and indeed, we have found that excess thymidine effectively induces cellular senescence in human cells. Further, many reports indicate the implication of chromatin proteins in cellular senescence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2019.01.001DOI Listing
March 2019
1 Read