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    5400 results match your criteria Ageing Research Reviews [Journal]

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    Mitochondrial depletion in CD4(+) and CD19(+) peripheral lymphocytes in early stage Alzheimer's disease.
    Mech Ageing Dev 2017 Sep 18;167:24-29. Epub 2017 Sep 18.
    HLA Typing Laboratory, Yeditepe University Hospital, İstanbul, Turkey; Department of Immunology, Faculty of Medicine, Yeditepe University, İstanbul, Turkey.
    Alzheimer's disease (AD) may be associated with mitochondrial defects. The aim of the present study was to investigate changes in mitochondrial abundance in peripheral lymphocytes of early and late stage AD patients. We analysed levels of mitochondrial DNA (mtDNA) and mean fluorescence intensity (MFI) of the mitochondria-specific antibody 113-1 in CD4(+), CD8(+), CD19(+) and CD56(+) peripheral lymphocytes of early and late stage AD by quantitative real-time PCR and flow cytometry, respectively. Read More

    Autophagy, its mechanisms and regulation: Implications in neurodegenerative diseases.
    Ageing Res Rev 2017 Sep 15. Epub 2017 Sep 15.
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
    Autophagy is a major regulatory cellular mechanism which gives the cell an ability to cope with some of the destructive events that normally occur within a metabolically living cell. This is done by maintaining the cellular homeostasis, clearance of damaged organelles and proteins and recycling necessary molecules like amino acids and fatty acids. There is a wide array of factors that influence autophagy in the state of health and disease. Read More

    AGE-DEPENDENT ATRIAL ARRHYTHMIC PHENOTYPE SECONDARY TO MITOCHONDRIAL DYSFUNCTION IN Pgc-1β DEFICIENT MURINE HEARTS.
    Mech Ageing Dev 2017 Sep 14. Epub 2017 Sep 14.
    Physiological Laboratory, University of Cambridge,Downing Street, Cambridge, CB2 3EG, United Kingdom; Department of Biochemistry, University of Cambridge,Tennis Court Road, Cambridge, CB2 1QW, United Kingdom. Electronic address:
    Introduction: Ageing and several age-related chronic conditions including obesity, insulin resistance and hypertension are associated with mitochondrial dysfunction and represent independent risk factors for atrial fibrillation (AF).

    Materials And Methods: Atrial arrhythmogenesis was investigated in Langendorff-perfused young (3-4 month) and aged (>12 month), wild type (WT) and peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β(-/-)) murine hearts modeling age-dependent chronic mitochondrial dysfunction during regular pacing and programmed electrical stimulation (PES).

    Results And Discussion: The Pgc-1β(-/-) genotype was associated with a pro-arrhythmic phenotype progressing with age. Read More

    Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis.
    Ageing Res Rev 2017 Sep 11. Epub 2017 Sep 11.
    Department of Medical Psychology, Donders Institute for Brain Cognitive function and Behaviour, Radboud university medical center, Nijmegen, The Netherlands; Department of Neuropsychology and Rehabilitation Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands. Electronic address:
    Combined cognitive and physical exercise interventions have potential to elicit cognitive benefits in older adults with mild cognitive impairment (MCI) or dementia. This meta-analysis aims to quantify the overall effect of these interventions on global cognitive functioning in older adults with MCI or dementia. Ten randomized controlled trials that applied a combined cognitive-physical intervention with cognitive function as an outcome measure were included. Read More

    Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases.
    Ageing Res Rev 2017 Sep 10;40:51-63. Epub 2017 Sep 10.
    National Animal Transmissible Spongiform Encephalopathy Laboratory and Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China. Electronic address:
    Neurons are highly energy demanding cells dependent on the mitochondrial oxidative phosphorylation system. Mitochondria generate energy via respiratory complexes that constitute the electron transport chain. Adenosine triphosphate depletion or glucose starvation act as a trigger for the activation of adenosine monophosphate-activated protein kinase (AMPK). Read More

    CELL REPROGRAMMING: THERAPEUTIC POTENTIAL AND THE PROMISE OF REJUVENATION FOR THE AGING BRAIN.
    Ageing Res Rev 2017 Sep 10. Epub 2017 Sep 10.
    Institute for Biochemical Research (INIBIOLP) - Histology B & Pathology B, School of Medicine, National University of La Plata, La Plata, Argentina. Electronic address:
    Aging is associated with a progressive increase in the incidence of neurodegenerative diseases, with Alzheimer's (AD) and Parkinson's (PD) disease being the most conspicuous examples. Within this context, the absence of efficacious therapies for most age-related brain pathologies has increased the interest in regenerative medicine. In particular, cell reprogramming technologies have ushered in the era of personalized therapies that not only show a significant potential for the treatment of neurodegenerative diseases but also promise to make biological rejuvenation feasible. Read More

    Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition.
    Ageing Res Rev 2017 Sep 9. Epub 2017 Sep 9.
    Department of Molecular Medicine, University of Padova, 35121 Padova, Italy; IMDEA-Food, 28049 Madrid, Spain.
    Ageing of the global population has become a public health concern with an important socio-economic dimension. Ageing is characterised by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed "inflammageing". The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defence, repair, turnover and adaptation of many tissues. Read More

    Regulated expression of the lncRNA TERRA and its impact on telomere biology.
    Mech Ageing Dev 2017 Sep 6;167:16-23. Epub 2017 Sep 6.
    Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico. Electronic address:
    The telomere protects against genomic instability by minimizing the accelerated end resection of the genetic material, a phenomenon that results in severe chromosome instability that could favor the transformation of a cell by enabling the emergence of tumor-promoting mutations. Some mechanisms that avoid this fate, such as capping and loop formation, have been very well characterized; however, telomeric non-coding transcripts, such as long non-coding RNAs (lncRNAs), should also be considered in this context because they play roles in the organization of telomere dynamics, involving processes such as replication, degradation, extension, and heterochromatin stabilization. Although the mechanism through which the expression of telomeric transcripts regulates telomere dynamics is not yet clear, a non-coding RNA component opens the research options in telomere biology and the impact that it can have on telomere-associated diseases such as cancer. Read More

    The role of nitric oxide in diabetic skin (patho)physiology.
    Mech Ageing Dev 2017 Aug 30. Epub 2017 Aug 30.
    Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia. Electronic address:
    The role of nitric oxide (NO) in cutaneous physiology/pathology became a growing research field since the discovery that almost all types of skin cells can synthetize this redox signaling molecule about 20 years ago. Now, it is evident that NO is an important player in skin physiological processes and in responses of cutaneous cells to external insults, while the impaired NO signaling has an important consequence in skin pathology. Skin disorders are common complications in diabetic conditions. Read More

    Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment.
    Mech Ageing Dev 2017 Aug 30. Epub 2017 Aug 30.
    Laboratory of Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224-6825, USA; Center for Translational Studies, Medical Service, VA Medical Center-DC, Washington DC, 20422, USA. Electronic address:
    During age-associated thymic involution, thymocytes decrease and lipid-laden cells accumulate. However, if and how aging affects the thymic lipid profile is not well understood, nor is it known if the hormonal milieu modifies this process. Here we demonstrate a correlation between reduced thymocyte numbers and markers of inflammation and oxidative stress with age. Read More

    Circadian clock as possible protective mechanism to pollution induced keratinocytes damage.
    Mech Ageing Dev 2017 Aug 30. Epub 2017 Aug 30.
    Department of Life Sciences and Biotechnology, Section of Medicinal and Health Products, University of Ferrara, I-44121 Ferrara, Italy; NC State University, Plants for Human Health Institute, Animal Science Dept., NC Research Campus, Kannapolis, NC 28081, USA. Electronic address:
    Ozone is among the most toxic environmental stressors to which we are continuously exposed. Due to its critical location, skin is one of the most susceptible tissues to oxidative stress damaging effect of ozone. An increasing collection of data suggests a significant role of circadian system in regulation of cellular response to oxidative stress. Read More

    Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study.
    Mech Ageing Dev 2017 Sep 8;167:1-4. Epub 2017 Sep 8.
    Department of Internal Medicine, Geriatrics Section, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; University Center for Geriatric Medicine, University Medical Center Groningen, Groningen, The Netherlands.
    Background: Melatonin plays a major role in maintaining circadian rhythm. Changes in melatonin metabolism might lead to circadian rhythm disturbances which are often observed in delirious patients.

    Aim: To assess if high morning plasma melatonin concentrations were associated with delirium. Read More

    The physiopathologic role of oxidative stress in skeletal muscle.
    Mech Ageing Dev 2017 Aug 26. Epub 2017 Aug 26.
    DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Italy; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Italy. Electronic address:
    Muscle senescence is a complex mechanism that is usually associated with a decrease in mass, strength and velocity of contraction. This state, known as sarcopenia, is a multifactorial process and it may be the consequence of several events, including accumulation of oxidative stress. The role of oxidative stress in the physiopathology of skeletal muscle is quite complex. Read More

    miRNAs in stem cell aging and age-related disease.
    Mech Ageing Dev 2017 Aug 25. Epub 2017 Aug 25.
    Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
    MicroRNAs (miRNAs) are short, non-coding RNAs that regulate the expression of mRNA targets and play a part in the post-transcriptional silencing. To date, the prominent roles of miRNAs in stem cells have been investigated in a wide range of biological processes, including self-renewal, differentiation and proliferation. In this commentary, we first demonstrate the causes and mechanisms of somatic stem cell aging in a new aspect of miRNAs. Read More

    Mechanisms of fetal epigenetics that determine telomere dynamics and health span in adulthood.
    Mech Ageing Dev 2017 Aug 26. Epub 2017 Aug 26.
    Laboratory for Molecular and Cellular Biology, Division of Molecular Biology, RBI, Zagreb, Croatia. Electronic address:
    Advances in epigenetics now enable us to better understand environmental influences on the genetic background of human diseases. This refers especially to fetal development where an adverse intrauterine environment impacts oxygen and nutrient supply to the fetus. Recently, differences in telomere length and telomere loss dynamics among individuals born with intrauterine growth restriction compared to normal controls have been described. Read More

    Genetically driven antioxidant capacity in a Caucasian Southeastern European population.
    Mech Ageing Dev 2017 Aug 26. Epub 2017 Aug 26.
    Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771, Athens, Greece. Electronic address:
    Previous studies have underlined the function of specific xenobiotic metabolizing phase-I or phase-II enzymes and endogenous antioxidant-related enzymes in the reduction and/or progression of oxidative stress and consequently the incidence of several diseases. In the present study, 10 polymorphic variants (rs4880, rs1799895, rs660339, rs1050450, rs1001179, rs28665122, rs1695, rs1138272, rs1051740 and rs2234922) were investigated in 1132 individuals of a Caucasian Southeastern European population. The frequency distribution of alleles and genotypes was compared to data of European (Northern, Central, Northwestern and Southwestern) and Global populations, extracted from the ensembl genome browser. Read More

    Role of DNA methylation in human age prediction.
    Mech Ageing Dev 2017 Sep 24;166:33-41. Epub 2017 Aug 24.
    Department of Neurology, Post Graduate Institute of Medical Education and Research(PGIMER), Chandigarh 160012, UT, India. Electronic address:
    DNA methylation (DNAm) is a fundamental biochemical modification which occurs over the lifespan of an individual and it is a significant component in the aging process. Methylation level of CpG sites plays an important role in finding the age of a person. Different approaches were used to extract age-related CpG (AR-CpG) sites for developing age-prediction models because the level of methylation is directly related to age for some CpG sites. Read More

    Age related depth profiles of human Stratum Corneum barrier-related molecular parameters by confocal Raman microscopy in vivo.
    Mech Ageing Dev 2017 Aug 24. Epub 2017 Aug 24.
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:
    In this study, stratum corneum (SC) depth profiles of hydrogen bound water molecule types, intercellular lipid (ICL) ordering, concentration of natural moisturizing factor (NMF) and keratin folding/unfolding properties are investigated in vivo for older (mean 50 years old) and younger (mean 29 years old) human skin using confocal Raman microscopy. The results show that the SC of the older group is modestly thicker (p<0.1), has more hydrogen bound water molecules at the depth 10-30% of the SC thickness (p<0. Read More

    Aging and immortality in unicellular species.
    Mech Ageing Dev 2017 Aug 24;167:5-15. Epub 2017 Aug 24.
    Graduate School of Arts and Sciences, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA. Electronic address:
    It has been historically thought that in conditions that permit growth, most unicellular species do not to age. This was particularly thought to be the case for symmetrically dividing species, as such species lack a clear distinction between the soma and the germline. Despite this, studies of the symmetrically dividing species Escherichia coli and Schizosaccharomyces pombe have recently started to challenge this notion. Read More

    HDAC inhibitors: A new promising drug class in anti-aging research.
    Mech Ageing Dev 2017 Sep 24;166:6-15. Epub 2017 Aug 24.
    Chebotarev State Institute of Gerontology NAMS of Ukraine, Kiev, Ukraine. Electronic address:
    In the last years, epigenetic regulation of gene expression is regarded as an important factor involved in a broad spectrum of aging-associated processes including loss of physical activity, frailty and genomic instability, and in development of various pathological conditions such as atherosclerosis, type 2 diabetes, cancer, immune deficits and neurodegenerative diseases. Accordingly, inhibitors of the members of superfamilies of histone deacetylases (HDACs) have been proposed, among other drugs targeting epigenetic pathways, as a promising type of therapeutics that is able to combat aging and its manifestations. The main focus of this article is a review of the literature describing the healthspan-promoting and life-extending effects of inhibitors of HDAC activity in both animal and clinical studies. Read More

    The senescent bystander effect is caused by ROS-activated NF-κB signalling.
    Mech Ageing Dev 2017 Aug 25. Epub 2017 Aug 25.
    The Ageing Biology Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK. Electronic address:
    Cell senescence is an important driver of the ageing process. The accumulation of senescent cells in tissues is accelerated by stress signals from senescent cells that induce DNA damage and ultimately senescence in bystander cells. We examine here the interplay of senescence-associated mitochondrial dysfunction (SAMD)-driven production of reactive oxygen species (ROS) and senescence-associated secretory phenotype (SASP) in causing the bystander effect. Read More

    Initiation of the age-related decline of odor identification in humans: A meta-analysis.
    Ageing Res Rev 2017 Aug 19;40:45-50. Epub 2017 Aug 19.
    School of Kinesiology, Shanghai University of Sport, 399 Chang Hai Road, Shanghai, 200438, P.R. China. Electronic address:
    Background: Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent or slow it.

    Objective: To determine the decade in which olfactory function begins to deteriorate in healthy humans by determining when odor identification is first impaired. Read More

    Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype.
    Mech Ageing Dev 2017 Sep 19;166:16-23. Epub 2017 Aug 19.
    Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address:
    Aging greatly increases the risk for intervertebral disc degeneration (IDD) as a result of proteoglycan loss due to reduced synthesis and enhanced degradation of the disc matrix proteoglycan (PG). How disc matrix PG homeostasis becomes perturbed with age is not known. The goal of this study is to determine whether cellular senescence is a source of this perturbation. Read More

    Is DNA damage indispensable for stress-induced senescence?
    Mech Ageing Dev 2017 Aug 16. Epub 2017 Aug 16.
    Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland. Electronic address:
    Cellular senescence is a fundamental trait of many eukaryotic organisms. Senescent cells participate both in the developmental program and in normal ageing and age-related diseases. Senescence of proliferation-prone cells is a state of permanent cell cycle arrest accompanied by metabolic activity manifested by high secretion levels of numerous factors, including pro-inflammatory ones. Read More

    The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway.
    Mech Ageing Dev 2017 Aug 10. Epub 2017 Aug 10.
    Univ. Lille, CNRS, Institut Pasteur de Lille, UMR8161, Mechanisms of Tumourigenesis and Targeted Therapies, Lille, France. Electronic address:
    Senescence is recognized as a cellular state acquired in response to various stresses. It occurs in correlation with the activation of the Unfolded Protein Response (UPR) pathway. However, the UPR targets which might relay the establishment of the senescent phenotype are not known. Read More

    Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.
    Ageing Res Rev 2017 Aug 10;40:31-44. Epub 2017 Aug 10.
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    This systematic review investigated whether the insulin sensitiser metformin has a geroprotective effect in humans. Pubmed and Embase were searched along with databases of unpublished studies. Eligible research investigated the effect of metformin on all-cause mortality or diseases of ageing relative to non-diabetic populations or diabetics receiving other therapies with adjustment for disease control achieved. Read More

    Role of Prion protein in premature senescence of human fibroblasts.
    Mech Ageing Dev 2017 Aug 8. Epub 2017 Aug 8.
    Unité de Recherche en Biologie Cellulaire (URBC) - Namur Research Institute for Life Sciences (Narilis), University of Namur, Belgium.
    Prion protein (PrP) is essentially known for its capacity to induce neurodegenerative prion diseases in mammals caused by a conformational change in its normal cellular isoform (PrP(C)) into an infectious and disease-associated misfolded form, called scrapie isoform (PrP(Sc)). Although its sequence is highly conserved, less information is available on its physiological role under normal conditions. However, increasing evidence supports a role for PrP(C) in the cellular response to oxidative stress. Read More

    Sirtuins, epigenetics and longevity.
    Ageing Res Rev 2017 Aug 5;40:11-19. Epub 2017 Aug 5.
    Department of General and Experimental Pathology, CEPT Laboratory, Medical University of Warsaw, ul. Pawińskiego 3C, 02-106 Warsaw, Poland.
    Aging of organisms begins from a single cell at the molecular level. It includes changes related to telomere shortening, cell senescence and epigenetic modifications. These processes accumulate over the lifespan. Read More

    Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells.
    Mech Ageing Dev 2017 Sep 5;166:1-5. Epub 2017 Aug 5.
    Department of Experimental Medicine, University of Genoa, Genoa, Italy. Electronic address:
    Long-term potentiation (LTP) and the process of memory formation require activation of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) pathways. Notably, recent evidence indicated that both cyclic nucleotides boost the production of amyloid-beta (Aβ) peptides. In particular, cAMP was shown to favor hippocampal LTP by stimulating the synthesis of the amyloid precursor protein APP, whereas cGMP was found to enhance LTP and to improve memory by increasing Aβ levels without affecting the expression of APP. Read More

    Dicarbonyls induce senescence of human vascular endothelial cells.
    Mech Ageing Dev 2017 Sep 3;166:24-32. Epub 2017 Aug 3.
    Department of Cardiac Surgery, University Hospital Halle, Germany. Electronic address:
    Rationale: Glyoxal (GO) and Methylglyoxal (MGO) are two dicarbonyls involved in the formation of advanced glycation end products (AGEs). Endothelial cells in the vessels are in constant contact with circulating AGEs and dicarbonyls. With this project, we aimed to elucidate the effect of GO and MGO on primary human vascular endothelial cells (HVECs). Read More

    Aging and osteoarthritis: Central role of the extracellular matrix.
    Ageing Res Rev 2017 Jul 31;40:20-30. Epub 2017 Jul 31.
    Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran; Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran; Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran. Electronic address:
    Osteoarthritis (OA), is a major cause of severe joint pain, physical disability and quality of life impairment in the aging population across the developed and developing world. Increased catabolism in the extracellular matrix (ECM) of the articular cartilage is a key factor in the development and progression of OA. The molecular mechanisms leading to an impaired matrix turnover have not been fully clarified, however cellular senescence, increased expression of inflammatory mediators as well as oxidative stress in association with an inherently limited regenerative potential of the tissue, are all important contributors to OA development. Read More

    Involvement of tRNAs in replication of human mitochondrial DNA and modifying effects of telomerase.
    Mech Ageing Dev 2017 Sep 29;166:55-63. Epub 2017 Jul 29.
    Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, United States; Xinxiang Medical University, Xinxiang, Henan, People's Republic of China; Department of Medicine, Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States. Electronic address:
    Overexpression of telomerase has been shown to significantly increase the lifespan of mice. When mechanistically attributed to repair of critically short telomeres, the lifespan extending action of telomerase cannot be reconciled with the observation that telomerase-null mice do not exhibit shortening of lifespan for at least two generations. We hypothesized that telomerase may interfere with replication of mitochondrial DNA (mtDNA) in a way that reduces formation of deletions - the primary cause of age-dependent cell attrition in non-renewable cells such as myocytes and neurons. Read More

    Proteome oxidative carbonylation during oxidative stress-induced premature senescence of WI-38 human fibroblasts.
    Mech Ageing Dev 2017 Jul 27. Epub 2017 Jul 27.
    Sorbonne Universités, UPMC Univ Paris 06, UMR 8256, Biological adaptation and ageing-IBPS, F-75005 Paris, France; CNRS UMR 8256, F-75005 Paris, France; INSERM U1164, F-75005 Paris, France. Electronic address:
    Accumulation of oxidatively damaged proteins is a hallmark of cellular and organismal ageing, and is also a phenotypic feature shared by both replicative senescence and stress-induced premature senescence of human fibroblasts. Moreover, proteins that are building up as oxidized (i.e. Read More

    Protein aggregation, cardiovascular diseases, and exercise training: Where do we stand?
    Ageing Res Rev 2017 Jul 28;40:1-10. Epub 2017 Jul 28.
    School of Health Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:
    Cells ensure their protein quality control through the proteostasis network. Aging and age-related diseases, such as neurodegenerative and cardiovascular diseases, have been associated to the reduction of proteostasis network efficiency and, consequently, to the accumulation of protein misfolded aggregates. The decline in protein homeostasis has been associated with the development and progression of atherosclerotic cardiovascular disease, cardiac hypertrophy, cardiomyopathies, and heart failure. Read More

    Use of near-infrared spectroscopy in the investigation of brain activation during cognitive aging: A systematic review of an emerging area of research.
    Ageing Res Rev 2017 Sep 26;38:52-66. Epub 2017 Jul 26.
    Centre de Recherches sur la Cognition et l'Apprentissage (UMR7295) Université de Poitiers and Université François-Rabelais de Tours, 5 rue Théodore Lefebvre TSA 21103, 86073 Poitiers Cedex 9, France; Laboratoire Sciences de la Cognition, Technologie, Ergonomie (SCoTE), Université de Toulouse, INU Champollion, Albi, France. Electronic address:
    The cognitive neuroscience of aging is a growing and stimulating research area. The development of neuroimaging techniques in the past two decades has considerably increased our understanding of the brain mechanisms that might underlie cognitive performance and resulting changes due to normal aging. Beside traditional metabolic neuroimaging techniques, such as Positron Emission Tomography and functional Magnetic Resonance Imaging, near infrared spectroscopy (NIRS), an optical imaging technique allowing to monitor real-time cerebral blood oxygenation, has gained recent interest in this field. Read More

    SIPS as a model to study age-related changes in proteolysis and aggregate formation.
    Mech Ageing Dev 2017 Jul 27. Epub 2017 Jul 27.
    Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany; German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. Electronic address:
    Aging is accompanied by the accumulation of cellular damage over time in response to stress, lifestyle and environmental factors ultimately leading to age-related diseases and death. Additionally, the number of senescent cells increases with age. Senescence is most likely not a static endpoint, it represents a series of hallmarks including morphological changes, alterations in protein turnover and accumulation of protein aggregates. Read More

    Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians.
    Mech Ageing Dev 2017 Jul 25. Epub 2017 Jul 25.
    Facultad de Medicina, Universidad de Valencia, Valencia, Spain; INCLIVA and Spanish Centenarian Study Group, Center for Biomedical Network Research on Frailty and Healthy Aging (CIBERFES), CIBER-ISCIII, Spain. Electronic address:
    Centenarians but not octogenarians up regulate the expression of miRNAs, as we previously reported. We have looked into miRNA biogenesis. We show that RNA POL II, DROSHA, EXPORTIN 5 and DICER, are up-regulated in centenarians compared with octogenarians. Read More

    CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis.
    Mech Ageing Dev 2017 Sep 25;166:64-68. Epub 2017 Jul 25.
    DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science and Technology (AIST), Central 5-41, 1-1-1 Higashi, Tsukuba, Ibaraki, 305 8565 Japan. Electronic address:
    CARF (Collaborator of ARF) was first identified as an ARF (Alternative Reading Frame, p14ARF)-interacting protein in a yeast two-hybrid interactive screening. Subsequently, it was shown to stabilize the p53-tumor suppressor protein in an ARF-dependent or -independent manner. It acts as a transcriptional repressor of HDM2 that exerts a negative feedback on p53 by its proteasomal-mediated degradation. Read More

    Oxidative stress and inhibition of nitric oxide generation underlie methotrexate-induced senescence in human colon cancer cells.
    Mech Ageing Dev 2017 Jul 21. Epub 2017 Jul 21.
    Laboratory of Molecular Basis of Ageing, Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warszawa, Poland.
    The response of human colon cancer C85 cells to methotrexate takes the form of reversible growth arrest of the type of stress-induced senescence. In the present study it is shown that during C85 cell progression into methotrexate-induced senescence, dihydrofolate reductase, the primary intracellular target for the drug, is stabilized at the protein level and its enzymatic activity, assayed in crude cellular extracts, decreases by 2-fold. Dihydrofolate reductase inhibition results in an increase in dihydrobiopterin level and an ultimate decrease in the tetrahydrobiopterin: dihydrobiopterin ratio in senescent cells. Read More

    Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules.
    Ageing Res Rev 2017 Sep 20;38:40-51. Epub 2017 Jul 20.
    School of Biomedical Sciences, Curtin University, Kent Street, Bentley, Western Australia 6102, Australia; Curtin Health Innovation Research Institute, Kent Street, Bentley, Western Australia 6102, Australia. Electronic address:
    Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells. However, little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules/pathways. Read More

    AMPK orchestrates an elaborate cascade protecting tissue from fibrosis and aging.
    Ageing Res Rev 2017 Sep 12;38:18-27. Epub 2017 Jul 12.
    Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China. Electronic address:
    Fibrosis is a common process characterized by excessive extracellular matrix (ECM) accumulation after inflammatory injury, which is also a crucial cause of aging. The process of fibrosis is involved in the pathogenesis of most diseases of the heart, liver, kidney, lung, and other organs/tissues. However, there are no effective therapies for this pathological alteration. Read More

    Age-dependent ventricular arrhythmias risk, structural and molecular remodeling in systemic arterial hypertension.
    Mech Ageing Dev 2017 Sep 10;166:48-54. Epub 2017 Jul 10.
    Unité de Neurocardiologie EA4612, Univlyon, Université de Lyon, Lyon, France; Hospices Civils de Lyon, Hôpital Louis Pradel, Service de Rythmologie, Lyon, France. Electronic address:
    Introduction: The left ventricular hypertrophy (LVH)-ventricular arrhythmias relationship associated with arterial hypertension and aging remains controversial. We aimed to assess the age-dependency of ventricular arrhythmias in spontaneously hypertensive rats (SHRs) and the corresponding ventricular structural and molecular remodeling.

    Materials And Methods: Ventricular arrhythmias were quantified using 24-h radiotelemetry ECG monitoring in eight SHRs and four Wistar-Kyoto (WKY) rats at 14 (young), 24 (adult), and 48 (aging) weeks of age. Read More

    Historical demography and longevity genetics: Back to the future.
    Ageing Res Rev 2017 Sep 5;38:28-39. Epub 2017 Jul 5.
    Department of Molecular Epidemiology, Leiden University, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address:
    Research into the genetic component of human longevity can provide important insights in mechanisms that may protect against age-related diseases and multi-morbidity. Thus far only a limited number of robust longevity loci have been detected in either candidate or genome wide association studies. One of the issues in these genetic studies is the definition of the trait being either lifespan, including any age at death or longevity, i. Read More

    Stress, cell senescence and organismal ageing.
    Mech Ageing Dev 2017 Jul 5. Epub 2017 Jul 5.
    Institute for Cell and Molecular Biosciences & Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, United Kingdom. Electronic address:
    Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key mechanism driving replicative senescence in human fibroblasts. Later, pioneering work by Olivier Toussaint and others showed that stress plays a major role in the induction of senescence in vitro, a phenomenon known as stress-induced premature senescence or SIPS. Read More

    In memoriam Olivier Toussaint - Stress-induced premature senescence and the role of DNA damage.
    Mech Ageing Dev 2017 Jul 3. Epub 2017 Jul 3.
    University of Konstanz, 78457 Konstanz, Germany. Electronic address:
    In the present paper, a concise review on the major contribution of our recently deceased colleague, Dr Olivier Toussaint, to the topic of stress-induced premature senescence (SIPS) of cells is presented together with a hypothesis on a mechanistic role of DNA damage, based on accumulating evidence for an important role of DNA damage as a driving factor in ageing. Read More

    A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction.
    Mech Ageing Dev 2017 Jul 3. Epub 2017 Jul 3.
    Institute of Molecular Biosciences and Cluster of Excellence Frankfurt 'Macromolecular Complexes', Department of Biosciences, J. W. Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany. Electronic address:
    Gossypol, a natural polyphenolic compound from cotton seeds, is known to trigger different forms of cell death in various types of cancer. Gossypol acts as a Bcl-2 inhibitor that induces apoptosis in apoptosis-competent cells. In apoptosis-resistant cancers such as glioblastoma, it triggers a non-apoptotic type of cell death associated with increased oxidative stress, mitochondrial depolarisation and fragmentation. Read More

    A viewpoint on considering physiological principles to study stress resistance and resilience with aging.
    Ageing Res Rev 2017 Sep 1;38:1-5. Epub 2017 Jul 1.
    Department of Health and Exercise Science, 201 Moby B Complex, Colorado State University, Fort Collins, CO, 80523-1582, USA. Electronic address:
    Adaptation to stress is identified as one of the seven pillars of aging research. Our viewpoint discusses the importance of the distinction between stress resistance and resilience, highlights how integration of physiological principles is critical for further understanding in vivo stress resistance and resilience, and advocates for the use of early warning signs to prevent a tipping point in stress resistance and resilience. Read More

    Centenarians as a 21st century healthy aging model: A legacy of humanity and the need for a world-wide consortium (WWC100+).
    Mech Ageing Dev 2017 Jul 23;165(Pt B):55-58. Epub 2017 Jun 23.
    IRCCS, Institute of Neurological Sciences of Bologna, 40139 Bologna, Italy; Department of Biology, Ecology and Earth Science, University of Calabria, Rende, CS, Italy; Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy; Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

    Physical activity and healthy ageing: A systematic review and meta-analysis of longitudinal cohort studies.
    Ageing Res Rev 2017 Sep 23;38:6-17. Epub 2017 Jun 23.
    Health Service and Population Research Department, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Centre for Global Mental Health, London, UK.
    Background: Older people constitute a significant proportion of the total population and their number is projected to increase by more than half by 2030. This increasing probability of late survival comes with considerable individual, economic and social impact. Physical activity (PA) can influence the ageing process but the specific relationship with healthy ageing (HA) is unclear. Read More

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