5,826 results match your criteria Ageing Research Reviews [Journal]


Sunlight and health: shifting the focus from vitamin D3 to photobiomodulation by red and near-infrared light.

Ageing Res Rev 2020 May 25:101089. Epub 2020 May 25.

Department of Public Health Solutions, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.

Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101089DOI Listing

Protective effects of carotenoid fucoxanthin in fibroblasts cellular senescence.

Mech Ageing Dev 2020 May 24:111260. Epub 2020 May 24.

Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia; Institute of Biology of FRC of Komi Scientific Center, Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia. Electronic address:

Fucoxanthin, as a main marine carotenoid, exhibit a wide variety of bioactivities, including antioxidant activity. Previously, we have shown the geroprotective activity of fucoxanthin on Drosophila and C. elegans. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111260DOI Listing

The Bright and Dark Side of Extracellular Vesicles in the Senescence-Associated Secretory Phenotype.

Mech Ageing Dev 2020 May 24:111263. Epub 2020 May 24.

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK. Electronic address:

Senescence is a state of proliferative arrest which has been described as a protective mechanism against the malignant transformation of cells. However, senescent cells have also been demonstrated to accumulate with age and to contribute to a variety of age-related pathologies. These pathological effects have been attributed to the acquisition of an enhanced secretory profile geared towards inflammatory molecules and tissue remodelling agents - known as the senescence-associated secretory phenotype (SASP). Read More

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http://dx.doi.org/10.1016/j.mad.2020.111263DOI Listing

The Bright and Dark Side of Extracellular Vesicles in the Senescence-Associated Secretory Phenotype.

Mech Ageing Dev 2020 May 24:111261. Epub 2020 May 24.

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK. Electronic address:

The recent advent of 'organs in a dish' has revolutionised the research landscape. These 3D culture systems have paved the way for translational, post genomics research by enabling scientists to model diseases in the laboratory, grow patient-derived organoids, and unite this technology with other cutting-edge methodologies such as drug discovery. Fields such as dermatology and neuroscience have revolutionised the development of robust 3D models, which faithfully recapitulate native physiology in vivo to provide important functional and mechanistic insights. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111261DOI Listing

Nutrition and the ageing brain: Moving towards clinical applications.

Ageing Res Rev 2020 May 24:101079. Epub 2020 May 24.

Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK. Electronic address:

The global increases in life expectancy and population have resulted in a growing ageing population and with it a growing number of people living with age-related neurodegenerative conditions and dementia, shifting focus towards methods of prevention, with lifestyle approaches such as nutrition representing a promising avenue for further development. This overview summarises the main themes discussed during the 3 Symposium on "Nutrition for the Ageing Brain: Moving Towards Clinical Applications" held in Madrid in August 2018, enlarged with the current state of knowledge on how nutrition influences healthy ageing and gives recommendations regarding how the critical field of nutrition and neurodegeneration research should move forward into the future. Specific nutrients are discussed as well as the impact of multi-nutrient and whole diet approaches, showing particular promise to combatting the growing burden of age-related cognitive decline. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101079DOI Listing

The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging).

Ageing Res Rev 2020 May 23:101091. Epub 2020 May 23.

Rostock University Medical Center, Institute for Clinical Chemistry and Laboratory Medicine, Rostock, Germany; Institute of Laboratory Medicine, Clinical Chemistry, and Pathobiochemistry, Charité University Medical Center, Berlin, Germany. Electronic address:

Fighting the current COVID-19 pandemic, we must not forget to prepare for the next. Since elderly and frail people are at high risk, we wish to predict their vulnerability, and intervene if possible. For example, it would take little effort to take additional swabs or dried blood spots. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245683PMC

Mitophagy during development and stress in C. elegans.

Mech Ageing Dev 2020 May 23:111266. Epub 2020 May 23.

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France; INSERM U1280, 91198, Gif-sur-Yvette, France. Electronic address:

Mitochondria is a key cellular organelle, which is tightly supervised by multiple oversight cellular mechanisms regulating mitochondrial biogenesis and mitochondria maintenance and/or elimination. Selective autophagy of mitochondria, id est mitophagy, is one of the cellular mechanisms controlling mitochondria homeostasis. The nematode Caenorhabditis elegans has recently emerged as a powerful model organism to study the roles and functions of mitophagy. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111266DOI Listing

Neuroinflammation in Pathogenesis of Alzheimer's Disease: Phytochemicals as Potential Therapeutics.

Mech Ageing Dev 2020 May 22:111259. Epub 2020 May 22.

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenka str., Ivano-Frankivsk, 76018, Ukraine.

Accumulation of neurotoxic forms of amyloid-β proteins in senile plaques and hyperphosphorylated tau proteins in neurofibrillary tangles is a well-known pathophysiological hallmark of Alzheimer's disease (AD). However, clinical trials with drugs targeting amyloid-β and tau have failed to demonstrate efficacy in treating AD. All currently FDA-approved anti-AD drugs have symptomatic effects only and are not able to cure this disease. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111259DOI Listing

Regulation of cellular senescence by microRNAs.

Mech Ageing Dev 2020 May 22:111264. Epub 2020 May 22.

Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China. Electronic address:

Cellular senescence is mainly characterized as a stable proliferation arrest and a senescence associated secretory phenotype (SASP). Senescence is triggered by diverse stimuli such as telomere shortening, oxidative stress, oncogene activation and DNA damage, and consequently contributes to multiple physiology and pathology outcomes, including embryonic development, wound healing and tumor suppression as well as aging or age-associated diseases. Interestingly, therapeutic clearance of senescent cells in tissues has recently been demonstrated to be beneficial for extending a healthy lifespan and for improving numerous age-related disorders. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111264DOI Listing

Lamin A involvement in ageing processes.

Ageing Res Rev 2020 May 21:101073. Epub 2020 May 21.

CNR Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza", Unit of Bologna, Bologna, Italy; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. Electronic address:

Lamin A, a main constituent of the nuclear lamina, is the major splicing product of the LMNA gene, which also encodes lamin C, lamin A delta 10 and lamin C2. Involvement of lamin A in the ageing process became clear after the discovery that a group of progeroid syndromes, currently referred to as progeroid laminopathies, are caused by mutations in LMNA gene. Progeroid laminopathies include Hutchinson-Gilford Progeria, Mandibuloacral Dysplasia, Atypical Progeria and atypical-Werner syndrome, disabling and life-threatening diseases with accelerated ageing, bone resorption, lipodystrophy, skin abnormalities and cardiovascular disorders. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101073DOI Listing

Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way.

Mech Ageing Dev 2020 May 21:111265. Epub 2020 May 21.

Department of Orthopaedic Surgery, University of Regensburg, Germany; Department of Orthopaedic Surgery, Experimental Orthopaedics, Centre for Medical Biotechnology (ZMB/Biopark 1), University of Regensburg, Germany. Electronic address:

Mice with an overall deletion of the sensory neuropeptide α-calcitonin gene-related peptide (α-CGRP) develop an age-dependent osteopenic bone phenotype. Underlying molecular mechanisms of how αCGRP affects bone cell metabolism are not well understood. This study aims to characterize differences in metabolic parameters of osteoblast-like cells (OB) and differentiated bone marrow-derived macrophages (BMM)/osteoclast (OC) cultures isolated from 3 month (3 m) and 9 month old (9 m) α-CGRP-deficient mice (-/-) and age-matched WT controls. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111265DOI Listing

The aging imageomics study: rationale, design and baseline characteristics of the study population.

Mech Ageing Dev 2020 May 10:111257. Epub 2020 May 10.

Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain; Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain; Institut d'Assistència Sanitària, Salt, Spain.

Biomarkers of aging are urgently needed to identify individuals at high risk of developing age-associated disease or disability. Growing evidence from population-based studies points to whole-body magnetic resonance imaging's (MRI) enormous potential for quantifying subclinical disease burden and for assessing changes that occur with aging in all organ systems. The Aging Imageomics Study aims to identify biomarkers of human aging by analyzing imaging, biopsychosocial, cardiovascular, metabolomic, lipidomic, and microbiomic variables. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111257DOI Listing

Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease.

Mech Ageing Dev 2020 May 17:111250. Epub 2020 May 17.

Thematic Task Force on Healthy Aging, CUECH Research Network; School of Medicine, Universidad de Magallanes, Punta Arenas, Chile; Laboratory of Molecular Medicine - LMM, Center for Education, Healthcare and Investigation - CADI, University of Magallanes, Punta Arenas, Chile.

Aging is a natural process that includes several changes that gradually make organisms degenerate and die. Harman's theory proposes that aging is a consequence of the progressive accumulation of oxidative modifications mediated by reactive oxygen/nitrogen species, which plays an essential role in the development and progression of many neurodegenerative diseases. This review will focus on how abnormal redox modifications induced by age impair the functionality of neuronal redox-sensitive proteins involved in axonal elongation and guidance, synaptic plasticity, and intercellular communication. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111250DOI Listing

Derivation of a measure of physiological multisystem dysregulation: Results from WHAS and health ABC.

Mech Ageing Dev 2020 May 11;188:111258. Epub 2020 May 11.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Introduction: Multifactorial biological processes underpin dysregulation over several individual physiological systems. However, it is challenging to characterize and model this multisystemic dysregulation and its relationship with individual physiologic systems. We operationalized a theory-driven measure of multisystem dysregulation and empirically tested for measurement differences by key characteristics. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111258DOI Listing

Effects of lifelong exercise on age-related body composition, oxidative stress, inflammatory cytokines, and skeletal muscle proteome in rats.

Mech Ageing Dev 2020 May 15:111262. Epub 2020 May 15.

School of Sport Sciences, Nanjing Normal University, Nanjing, China; School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. Electronic address:

Purpose: This study aims to evaluate whether regular lifelong exercise has effects on age-related inflammatory cytokines, oxidative stress, and the skeletal muscle proteome.

Methods: Four groups of adult-aged (8-month-old) female Sprague Dawley rats were used: rats for which training was initiated at either 8 (8 M-MICT, moderate-intensity continuous training) or 18 months (18 M-MICT) and sedentary rats aged either 26 (26 M-SED) or 8 months (8M-SED), who served as aging and adult sedentary controls, respectively. Aged skeletal muscles were subjected to proteomic and Kyoto Encyclopedia of Genes and Genomes (KEGG) and immunoblotting analyses. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111262DOI Listing

Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases.

Ageing Res Rev 2020 May 19;61:101069. Epub 2020 May 19.

Department of Brain & Cognitive Sciences, DGIST, Daegu, Republic of Korea. Electronic address:

Treatment options for many neurodegenerative diseases are limited due to the lack of early diagnostic procedures that allow timely delivery of therapeutic agents to affected neurons prior to cell death. While notable advances have been made in neurodegenerative disease biomarkers, whether or not the biomarkers discovered to date are useful for early diagnosis remains an open question. Additionally, the reliability of these biomarkers has been disappointing, due in part to the large dissimilarities between the tissues traditionally used to source biomarkers and primarily diseased neurons. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101069DOI Listing

Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies.

Ageing Res Rev 2020 May 11:101078. Epub 2020 May 11.

Molecular Neuroscience and Functional Genomics Laboratory, Delhi Technological University (Formerly DCE), Delhi 110042, India. Electronic address:

The abnormal accumulation of neurotoxic proteins is the typical hallmark of various age-related neurodegenerative disorders (NDDs), including Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis and Multiple sclerosis. The anomalous proteins, such as Aβ, Tau in Alzheimer's disease and α-synuclein in Parkinson's disease, perturb the neuronal physiology and cellular homeostasis in the brain thereby affecting the millions of human lives across the globe. Here, ubiquitin proteasome system (UPS) plays a decisive role in clearing the toxic metabolites in cells, where any aberrancy is widely reported to exaggerate the neurodegenerative pathologies. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101078DOI Listing
May 2020
4.940 Impact Factor

The role of Sestrins in the regulation of the aging process.

Mech Ageing Dev 2020 May 7;188:111251. Epub 2020 May 7.

Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, Sichuan, China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. Electronic address:

Sestrins (Sesns) represent a highly conserved family of stress-inducing proteins that are involved in antioxidant and autophagy regulatory functions. They are very important mediators as they can protect the cells under a variety of noxious stimulating conditions. However, the functions of Sesns in aging has not yet been fully understood. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111251DOI Listing

Sleep, Noninvasive Brain Stimulation, and the Aging Brain: Challenges and Opportunities.

Ageing Res Rev 2020 May 4;61:101067. Epub 2020 May 4.

Siena Brain Investigation and Neuromodulation Lab (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Italy; Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

As we age, sleep patterns undergo severe modifications of their micro and macrostructure, with an overall lighter and more fragmented sleep structure. In general, interventions targeting sleep represent an excellent opportunity not only to maintain life quality in the healthy aging population, but also to enhance cognitive performance and, when pathology arises, to potentially prevent/slow down conversion from e.g. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101067DOI Listing

Long-lived post-mitotic cell aging: is a telomere clock at play?

Mech Ageing Dev 2020 May 4:111256. Epub 2020 May 4.

Université Côte d'Azur, Nice, France CNRS, Inserm, Institut for Research on Cancer and Aging, Nice (IRCAN), France; Department of Medical Genetics, Archet 2 Hospital, FHU Oncoage, CHU of Nice, Nice, France. Electronic address:

Senescence is a cellular response to stress for both dividing and post-mitotic cells. Noteworthy, long-lived post-mitotic cells (collectively named LLPMCs), which can live for decades in the organism, can exhibit a distinct type of cellular aging characterized by a progressive functional decline not associated to an overt senescence phenotype. The age-related drivers of senescence and aging in LLPMCs remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111256DOI Listing

Interactions between season of birth, chronological age and genetic polymorphisms in determining later-life chronotype.

Mech Ageing Dev 2020 May 1;188:111253. Epub 2020 May 1.

Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, UK.

Human chronotype, the temporal pattern of daily behaviors, is influenced by postnatal seasonal programming and ageing. The aim of this study was to investigate genetic variants that are associated with season of birth programming and longitudinal chronotype change. Longitudinal sleep timing and genotype data from 1449 participants were collected for up to 27 years. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111253DOI Listing
May 2020
3.397 Impact Factor

Instrumented measures of sedentary behaviour and physical activity are associated with mortality in community-dwelling older adults: A systematic review, meta-analysis and meta-regression analysis.

Ageing Res Rev 2020 Apr 29:101061. Epub 2020 Apr 29.

Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands; Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, 300 Grattan Street, Parkville, Victoria 3050, Melbourne, Australia. Electronic address:

Background: Sedentary behaviour (SB) and physical activity (PA) can be objectively assessed with inertial sensors to describe bodily movement. Higher SB and lower PA is associated with higher chronological age and negative health outcomes. This study aimed to quantify the association between instrumented measures of SB (i-SB) and PA (i-PA) and mortality in community-dwelling older adults, to subsequently compare the quantitative effect sizes and to determine the dose-response relationships. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101061DOI Listing

Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China.

Authors:
Char Leung

Mech Ageing Dev 2020 Apr 27;188:111255. Epub 2020 Apr 27.

Deakin University, 221 Burwood Highway, Burwood, 3125, Australia. Electronic address:

While elderly patients are at high risk of fatality, research concerning COVID-19 has largely been done on clarifying the clinical features. As such, the present work aims to identify risk factors for mortality in elderly patients with COVID-19. Given that single-centre studies are less likely informative as elderly remains a minority in the total Chinese population, the present study reviewed the clinical data of geriatric COVID-19 patients gathered from different sources in the public domain. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184979PMC

The emerging role of T follicular helper (T) cells in aging: Influence on the immune frailty.

Ageing Res Rev 2020 Apr 25:101071. Epub 2020 Apr 25.

Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy; Istituti Clinici Scientifici Maugeri SpA Società Benefit (ICS Maugeri SpA SB), Telese Terme, BN, Italy.

The world population is undergoing a rapid expansion of older adults. Aging is associated with numerous changes that affect all organs and systems, including every component of the immune system. Immunosenescence is a multifaceted process characterized by poor response to vaccine and higher incidence of bacterial and viral infections, cancer, cardiovascular and autoimmune diseases. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101071DOI Listing
April 2020
4.940 Impact Factor

The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation.

Mech Ageing Dev 2020 Apr 25;188:111254. Epub 2020 Apr 25.

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA. Electronic address:

Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. Recent studies reveal a mitochondrial metabolic checkpoint that regulates stem cell quiescence and maintenance, and dysregulation of the checkpoint leads to functional deterioration of aged stem cells. Here, we present the evidence supporting the mitochondrial metabolic checkpoint regulating stem cell aging and demonstrating the feasibility to target this checkpoint to reverse stem cell aging. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111254DOI Listing

Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of brain regional GABA system and corticosterone status.

Mech Ageing Dev 2020 Apr 24:111248. Epub 2020 Apr 24.

Department of Pharmaceutical Technology, Jadavpur University, 188, Raja S.C. Mallick Road, Kolkata, 700032, India. Electronic address:

Aging is known to affect adversely the corticosterone status and the brain function including cognition. Calorie restricted (CR) diet has been found to reduce stress factors and improve brain aging. The objective of the present investigation is to study the effect of short-term CR diet without any food deprivation on aging-induced impairment of cognitive function in relation to the corticosterone status and the brain regional GABA system. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111248DOI Listing

Pleiotropic effects of polyphenols on glucose and lipid metabolism: Focus on clinical trials.

Ageing Res Rev 2020 Apr 23;61:101074. Epub 2020 Apr 23.

Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy.

Epidemiological evidence from observational studies suggests that dietary polyphenols (PPs) - phytochemicals found in a variety of plant-based foods - can reduce the risk of developing type 2 diabetes mellitus (T2DM). Clinical trials have also indicated that PPs may help manage the two key features of T2DM, hyperglycemia and dyslipidemia. Since the incidence of T2DM is dramatically increasing worldwide, identifying food-based approaches that can reduce the risk of developing it and help manage its main risk factors in early-stage disease has clinical and socioeconomic relevance. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101074DOI Listing
April 2020
4.940 Impact Factor

The environment as a determinant of successful aging or frailty.

Mech Ageing Dev 2020 Apr 24;188:111244. Epub 2020 Apr 24.

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy.

The number of elderly persons is rising rapidly, and healthspan is a key factor in determining the well-being of individuals and the sustainability of national health systems. Environmental health is crucial for a "successful aging". Complex relationships between environmental factors and non-communicable diseases play a major role, causing or accelerating disabilities. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111244DOI Listing

Sex-specific differences in age-related aortic valve calcium load: A systematic review and meta-analysis.

Ageing Res Rev 2020 Apr 22;61:101077. Epub 2020 Apr 22.

Centro Cardiologico Monzino IRCCS, Milan, Italy. Electronic address:

Aging of the aortic valve, characterized by leaflet thickening and loss of extensibility, leads to progressive changes in valve function. These age-related mechanisms have not been evaluated yet in sex-specific calcific aortic valve stenosis (CAVS) onset and progression. Recent studies reported the association between high aortic valve calcification (AVC) load and male gender in patients with CAVS while women present faster progression than men. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101077DOI Listing

Effects of exercise interventions on the functional status of acutely hospitalised older adults: A systematic review and meta-analysis.

Ageing Res Rev 2020 Apr 21;61:101076. Epub 2020 Apr 21.

Faculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain; Biomedical Research Networking Center on Frailty and Healthy Aging (CIBERFES), Madrid, Spain; Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain. Electronic address:

Background: Acute hospitalisation can have adverse effects in older adults, notably functional decline. We aimed to summarize evidence on the effects of exercise interventions in acutely hospitalised older adults.

Methods: Relevant articles were systematically searched (PubMed, Web of Science, Rehabilitation & Sports Medicine Source, and EMBASE) until 19 March 2020. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101076DOI Listing

Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies.

Mech Ageing Dev 2020 Apr 21;188:111252. Epub 2020 Apr 21.

Institute of Clinical Chemistry and Laboratory Diagnostic, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; IUF- Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. Electronic address:

Aging is characterized by the deterioration of different cellular and organismal structures and functions. A typical hallmark of the aging process is the accumulation of dysfunctional mitochondria and excess iron, leading to a vicious cycle that promotes cell and tissue damage, which ultimately contribute to organismal aging. Accordingly, altered mitochondrial quality control pathways such as mitochondrial autophagy (mitophagy) as well as altered iron homeostasis, with consequent iron overload, can accelerate the aging process and the development and progression of different age-associated disorders. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111252DOI Listing

MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?

Ageing Res Rev 2020 Apr 20;61:101075. Epub 2020 Apr 20.

Department of Psychology and Neuroscience, Duke University, 2020 West Main Street, Suite 030, Durham, NC, 27701, USA. Electronic address:

The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration has occurred. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101075DOI Listing

SIRT1 Regulation in Ageing and Obesity.

Mech Ageing Dev 2020 Apr 19;188:111249. Epub 2020 Apr 19.

Pulmonary and Critical Care medicine, Department of Medicine, Baylor College of Medicine, Houston TX 77030, USA. Electronic address:

Ageing and obesity have common hallmarks: altered glucose and lipid metabolism, chronic inflammation and oxidative stress are some examples. The downstream effects of SIRT1 activity have been thoroughly explored, and their research is still in expanse. SIRT1 activation has been shown to regulate pathways with beneficiary effects on 1) ageing and obesity-associated metabolic disorders such as metabolic syndrome, insulin resistance and type-II diabetes with, 2) chronic inflammatory processes such as arthritis, atherosclerosis and emphysema, 3) DNA damage and oxidative stress with impact on neurodegenerative diseases, cardiovascular health and some cancers. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111249DOI Listing

Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age.

Ageing Res Rev 2020 Jul 18;60:101070. Epub 2020 Apr 18.

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, United States; Paul F. Glenn Center for the Biology of Aging, Stanford University, Stanford, CA, United States.

The development of clinical interventions that significantly improve human healthspan requires robust markers of biological age as well as thoughtful therapeutic targets. To promote these goals, we performed a systematic review and analysis of human aging and proteomics studies. The systematic review includes 36 different proteomics analyses, each of which identified proteins that significantly changed with age. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101070DOI Listing

Muscle stem cell aging: identifying ways to induce tissue rejuvenation.

Mech Ageing Dev 2020 Apr 18;188:111246. Epub 2020 Apr 18.

Department of Experimental & Health Sciences, University Pompeu Fabra (UPF), CIBERNED, ICREA, 08003, Barcelona, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28019, Madrid, Spain. Electronic address:

Aging is characterized by the functional and regenerative decline of tissues and organs. This regenerative decline is a consequence of the numerical and functional loss of adult stem cells, which are the corner stone of tissue homeostasis and repair. A palpable example of this decline is provided by skeletal muscle, a specialized tissue composed of postmitotic myofibers that contract to generate force. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111246DOI Listing

The multi-faceted impact of methamphetamine on Alzheimer's disease: From a triggering role to a possible therapeutic use.

Ageing Res Rev 2020 Jul 15;60:101062. Epub 2020 Apr 15.

Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand; Centre National de la Recherche Scientifique, 2 rue Michel Ange, 75016, Paris, France. Electronic address:

Although it has been initially synthesized for therapeutic purposes and currently FDA-approved and prescribed for obesity, attention-deficit/hyperactivity disorder, narcolepsy and depression, methamphetamine became a recreational drug that is nowadays massively manufactured illegally. Because it is a powerful and extremely addictive psychotropic agent, its abuse has turned out to become a major health problem worldwide. Importantly, the numerous effects triggered by this drug induce neurotoxicity in the brain ultimately leading to serious neurological impairments, tissue damage and neuropsychological disturbances that are reminiscent to most of the symptoms observed in Alzheimer's disease and other pathological manifestations in aging brain. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101062DOI Listing

Targeting senescent cells to attenuate cardiovascular disease progression.

Ageing Res Rev 2020 Jul 13;60:101072. Epub 2020 Apr 13.

Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA, 30303, United States.

Cardiovascular disease (CVD) is the most common disease to increase as life expectancy increases. Most high-profile pharmacological treatments for age-related CVD have led to inefficacious results, implying that novel approaches to treating these pathologies are needed. Emerging data have demonstrated that senescent cardiovascular cells, which are characterized by irreversible cell cycle arrest and a distinct senescence-associated secretory phenotype, accumulate in aged or diseased cardiovascular systems, suggesting that they may impair cardiovascular function. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101072DOI Listing
July 2020
4.940 Impact Factor

The mechanism of lncRNA H19 in fibrosis and its potential as novel therapeutic target.

Mech Ageing Dev 2020 Apr 13;188:111243. Epub 2020 Apr 13.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 Yanta West Road, Xi'an, 710061, China.

Fibrosis is widely observed in multiple organs, which is generally associated with aging-related diseases, including liver fibrosis, lung fibrosis, cardiac fibrosis and renal fibrosis. The excess deposition of extracellular matrix ultimately leads to the disruption of organ architecture and loss of function. H19 is paternally imprinted maternally expressed lncRNA, which is highly expressed during the development of embryo but quickly downregulated after birth. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111243DOI Listing

Proteomics as a reliable approach for discovery of blood-based Alzheimer's disease biomarkers: A systematic review and meta-analysis.

Ageing Res Rev 2020 Jul 12;60:101066. Epub 2020 Apr 12.

Faculty of Pharmacy, University Teknologi MARA (UiTM) Cawangan Selangor, Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia; Collaborative Drug Discovery Research (CDDR) Group, Pharmaceutical and Life Sciences Community of Research, Universiti Teknologi MARA (UiTM) Shah Alam, 40450 Shah Alam, Selangor Darul Ehsan, Malaysia. Electronic address:

In order to gauge the impact of proteomics in discovery of Alzheimer's disease (AD) blood-based biomarkers, this study had systematically reviewed articles published between 1984-2019. Articles that fulfilled the inclusion criteria were assessed for risk of bias. A meta-analysis was performed for replicable candidate biomarkers (CB). Read More

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http://dx.doi.org/10.1016/j.arr.2020.101066DOI Listing
July 2020
4.940 Impact Factor

Mitophagy in cardiovascular homeostasis.

Mech Ageing Dev 2020 Apr 11;188:111245. Epub 2020 Apr 11.

Departments of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. Electronic address:

Mitochondria are essential organelles that generate energy to fuel myocardial contraction. Accumulating evidence also suggests that, in the heart, mitochondria may contribute to specific aspects of disease progression through the regulations of specific metabolic intermediates, as well as the transcriptional and epigenetic states of cells. If damaged, the mitochondria and their related pathways are hindered, which may result in or contribute to the development of a wide range of cardiovascular diseases. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111245DOI Listing

Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging.

Ageing Res Rev 2020 Jul 10;60:101068. Epub 2020 Apr 10.

Developmental Toxicology Division, Systems Toxicology and Health Risk Assessment Group, CSIR- Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan,31 Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India; Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Raebareli, Munsiganj, Raebareli 229405, UP, India. Electronic address:

The progressive loss of neuronal structure and functions resulting in the death of neurons is considered as neurodegeneration. Environmental toxicants induced degeneration of neurons is accelerated with aging. In adult brains, most of the neurons are post-mitotic, and their loss results in the development of diseases like amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). Read More

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http://dx.doi.org/10.1016/j.arr.2020.101068DOI Listing

Effects of transcranial electrical stimulation on episodic memory in physiological and pathological ageing.

Ageing Res Rev 2020 Apr 8:101065. Epub 2020 Apr 8.

Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Memory for personally-relevant past events (episodic memory) is critical for activities of daily living. Decline in this type of declarative long-term memory is a common characteristic of healthy ageing, a process accelerated in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Transcranial electrical stimulation (tES) has been used as a strategy to ameliorate episodic memory. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101065DOI Listing

Wnt signaling pathway in aging-related tissue fibrosis and therapies.

Ageing Res Rev 2020 Jul 6;60:101063. Epub 2020 Apr 6.

Faculty of Life Science & Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi, 710069, China. Electronic address:

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the pathogenesis of various chronic diseases and aging-related organ failure to fully control chronic wound-healing and restoring tissue function. The process of fibrosis is involved in the pathogenesis of the kidney, lung, liver, heart and other tissue disorders. Wnt is a highly conserved signaling in the aberrant wound repair and fibrogenesis, and sustained Wnt activation is correlated with the pathogenesis of fibrosis. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101063DOI Listing
July 2020
4.940 Impact Factor

Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities.

Ageing Res Rev 2020 Jul 6;60:101050. Epub 2020 Apr 6.

InSilico Medicine, Science Park, Hong Kong; Biogerontology Research Foundation, London, UK; Buck Institute for Research on Aging, Novato, USA. Electronic address:

The aging process results in multiple traceable footprints, which can be quantified and used to estimate an organism's age. Examples of such aging biomarkers include epigenetic changes, telomere attrition, and alterations in gene expression and metabolite concentrations. More than a dozen aging clocks use molecular features to predict an organism's age, each of them utilizing different data types and training procedures. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101050DOI Listing

12 days of in vivo caloric reduction can improve important parameters of aging in humans.

Mech Ageing Dev 2020 Apr 6;188:111238. Epub 2020 Apr 6.

Department of Life Sciences, Albstadt-Sigmaringen University of Applied Sciences, Sigmaringen, Germany.

Caloric reduction (CR) is considered as the most reasonable intervention to delay aging and age-related diseases. Numerous studies in various model organisms provide the main basis for this hypothesis. Human studies exist, but they differ widely in study design, characteristics of test persons and study outcome. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111238DOI Listing

Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages.

Ageing Res Rev 2020 Jul 5;60:101064. Epub 2020 Apr 5.

Institut de Systématique, Evolution, Biodiversité (ISYEB), Sorbonne Université, CNRS, Museum National d'Histoire Naturelle, EPHE, Université des Antilles, Paris, France. Electronic address:

Life has persisted for about 3.5 billion years (Gy) despite fluctuating environmental pressures and the aging and mortality of individuals. The disposable soma theory (DST) notoriously contributes to explain this persistence for lineages with a clear soma/germen distinction. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101064DOI Listing

Aging Fits the Disease Criteria of the International Classification of Diseases.

Mech Ageing Dev 2020 Apr 3:111230. Epub 2020 Apr 3.

International Longevity Alliance, 19 avenue Jean Jaurès, Sceaux, 92330, France.

The disease criteria used by the World Health Organization (WHO) were applied to human biological aging in order to assess whether aging can be classified as a disease. These criteria were developed for the 11th revision of the International Classification of Diseases (ICD) and included disease diagnostics, mechanisms, course and outcomes, known interventions, and linkage to genetic and environmental factors. RESULTS: Biological aging can be diagnosed with frailty indices, functional, blood-based biomarkers. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111230DOI Listing

Functional roles of circular RNAs in Alzheimer's disease.

Ageing Res Rev 2020 Jul 29;60:101058. Epub 2020 Mar 29.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Pharmacy School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China; Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China. Electronic address:

Although efforts have been made to develop therapeutic approaches, the clinical management of AD maintains a major challenge. CircRNAs are highly abundant and evolutionarily conserved in neuronal tissues in mammals. Accumulating data suggest that circRNAs regulate biological and pathological processes by sponging miRNAs, binding to RBPs, modulating mRNA stability, and being translated into peptides in various diseases, serving as biomarkers and potential therapeutic targets. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101058DOI Listing

BRAIN LIPID PEROXIDATION AND ALZHEIMER DISEASE: SYNERGY BETWEEN THE BUTTERFIELD AND MATTSON LABORATORIES.

Ageing Res Rev 2020 Mar 20:101049. Epub 2020 Mar 20.

Department of Chemistry and Sanders-Brown Center on Aging, University Of Kentucky, Lexington, KY, 40506, United States. Electronic address:

Brains from persons with Alzheimer disease (AD) and its earlier stage, amnestic mild cognitive impairment (MCI), exhibit high levels of oxidative damage, including that to phospholipids. One type of oxidative damage is lipid peroxidation, the most important index of which is protein-bound 4-hydroxy-2-trans-nonenal (HNE). This highly reactive alkenal changes the conformations and lowers the activities of brain proteins to which HNE is covalently bound. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101049DOI Listing