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    5456 results match your criteria Ageing Research Reviews [Journal]

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    The epigenetic alterations of endogenous retroelements in aging.
    Mech Ageing Dev 2018 Feb 16. Epub 2018 Feb 16.
    Advanced Technology Center for Aging Research, Scientific Technological Area, Italian National Research Center on Aging (INRCA), via Birarelli 8, 6011 Ancona, Italy. Electronic address:
    Endogenous retroelements, transposons that mobilize through RNA intermediates, include some of the most abundant repetitive sequences of the human genome, such as Alu and LINE-1 sequences, and human endogenous retroviruses. Recent discoveries demonstrate that these mobile genetic elements not only act as intragenomic parasites, but also exert regulatory roles in living cells. The risk of genomic instability represented by endogenous retroelements is normally counteracted by a series of epigenetic control mechanisms which include, among the most important, CpG DNA methylation. Read More

    GIT2-A keystone in ageing and age-related disease.
    Ageing Res Rev 2018 Feb 13;43:46-63. Epub 2018 Feb 13.
    Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Translational Neurobiology Group, Center of Molecular Neurology, VIB, Antwerp, Belgium. Electronic address:
    Since its discovery, G protein-coupled receptor kinase-interacting protein 2, GIT2, and its family member, GIT1, have received considerable interest concerning their potential key roles in regulating multiple inter-connected physiological and pathophysiological processes. GIT2 was first identified as a multifunctional protein that is recruited to G protein-coupled receptors (GPCRs) during the process of receptor internalization. Recent findings have demonstrated that perhaps one of the most important effects of GIT2 in physiology concerns its role in controlling multiple aspects of the complex ageing process. Read More

    Healthy brain aging: Interplay between reactive species, inflammation and energy supply.
    Ageing Res Rev 2018 Feb 13;43:26-45. Epub 2018 Feb 13.
    Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str, Ivano-Frankivsk, 76018, Ukraine. Electronic address:
    Brains' high energy expenditure with preferable utilization of glucose and ketone bodies, defines the specific features of its energy homeostasis. The extensive oxidative metabolism is accompanied by a concomitant generation of high amounts of reactive oxygen, nitrogen, and carbonyl species, which will be here collectively referred to as RONCS. Such metabolism in combination with high content of polyunsaturated fatty acids creates specific problems in maintaining brains' redox homeostasis. Read More

    Cellular senescence: Immunosurveillance and future immunotherapy.
    Ageing Res Rev 2018 Feb 7;43:17-25. Epub 2018 Feb 7.
    Centre for Biological Engineering, Wolfson School of Manufacturing and Mechanical, Engineering, Holywell Park, Loughborough University, LE11 3TU.
    In response to persistent DNA damage, induction into cell senescence promotes an immunogenic program which facilitates immune clearance of these damaged cells. Under physiological conditions, senescent cells can activate both innate and adaptive immune responses, functioning to maintain tissue homeostasis. In addition, emerging findings suggest that programmed induction of cell senescence may be important for regulating reproductive processes, partly facilitated by immune clearance. Read More

    Aging and nutrition induce tissue-specific changes on global DNA methylation status in rats.
    Mech Ageing Dev 2018 Feb 7. Epub 2018 Feb 7.
    Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, 87036 Rende, Italy. Electronic address:
    A number of epigenetic studies have demonstrated that DNA methylation patterns exhibit a tissue specificity, but not much has been done to highlight the extent of this phenomenon. Moreover, it is unknown how external factors modulate the plasticity of the tissue specific epigenetic profile. We examined global DNA methylation profiles in tissues from rats of different age, fed with standard or low-calorie diet, and evaluated their association with aging and nutrition. Read More

    Increasing use of cognitive measures in the operational definition of frailty-A systematic review.
    Ageing Res Rev 2018 Feb 7;43:10-16. Epub 2018 Feb 7.
    Gerontology department, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium; Frailty in Ageing (FRIA) Research department, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium; Department of Geriatrics, Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, B-1090, Brussels, Belgium.
    Ageing is associated both with frailty and cognitive decline. The quest for a unifying approach has led to a new concept: cognitive frailty. This systematic review explores the contribution of cognitive assessment in frailty operationalization. Read More

    The role of Snf5 in the osteogenic differentiation potential during replicative senescence of rat mesenchymal stromal cells.
    Mech Ageing Dev 2018 Feb 1. Epub 2018 Feb 1.
    Department of Anatomy and Embryology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, PR China.
    The osteogenic capacities of bone marrow-derived stromal cells (BMSCs) diminish during replicative senescence, and these changes affect the success of therapeutic application of BMSCs. In this study, we sought to explore the molecular mechanisms underlying the osteogenic differentiation capacities that occur during replicative senescence. It is well known that Oct4 is a key transcription factor essential for maintaining differentiation capacities of the stem cells. Read More

    Procancerogenic activity of senescent cells: A case of the peritoneal mesothelium.
    Ageing Res Rev 2018 Jan 31;43:1-9. Epub 2018 Jan 31.
    Department of Hypertensiology, Angiology and Internal Medicine, Poznań University of Medical Sciences, Długa 1/2 Str., 61-848 Poznań, Poland. Electronic address:
    Human peritoneal mesothelial cells belong to a narrow group of somatic cells in which both the triggers and the mechanisms of senescence have already been well defined. Importantly, senescent mesothelial cells have been found in the peritoneal cavity in vivo. From a clinical point of view, peritoneal mesothelial cells have been recognized as playing a critical role in the intraperitoneal development of tumor metastases. Read More

    Altered function of neuronal L-type calcium channels in ageing and neuroinflammation: Implications in age-related synaptic dysfunction and cognitive decline.
    Ageing Res Rev 2018 Jan 12;42:86-99. Epub 2018 Jan 12.
    Dept. of Physiology, Yong Loo Lin School of Medicine, Singapore; Neurobiology/Ageing Program, Centre for Life Sciences, National University of Singapore, Singapore; National Neuroscience Institute, Singapore. Electronic address:
    The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant changes in synaptic plasticity and neuronal connections. Read More

    Back to the future: Epigenetic clock plasticity towards healthy aging.
    Mech Ageing Dev 2018 Jan 11. Epub 2018 Jan 11.
    Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp (UA), Belgium. Electronic address:
    Aging is the most important risk factor for major human lifestyle diseases, including cancer, neurological and cardiometabolic disorders. Due to the complex interplay between genetics, lifestyle and environmental factors, some individuals seem to age faster than others, whereas centenarians seem to have a slower aging process. Therefore, a biochemical biomarker reflecting the relative biological age would be helpful to predict an individual's health status and aging disease risk. Read More

    Integrated study on comparative transcriptome and skeletal muscle function in aged rats.
    Mech Ageing Dev 2018 Jan 8;169:32-39. Epub 2018 Jan 8.
    Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Friendship Road 1, Yuan Jiagang, 400016, Chongqing, China. Electronic address:
    The present study aimed to reveal aging-related changes in the skeletal muscle of SD rats by comparing transcriptome analysis, integrated with muscle physiological parameters. Ten rats aged 25 months were set as the old group (OG) and ten rats aged 6 months were set as the young group (YG). After 6 weeks of feeding, the body mass, grip strength, and gastrocnemius muscle mass were determined, and the differentially expressed genes were analyzed by transcriptome sequencing, followed by GO enrichment analysis and KEGG analysis. Read More

    Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
    Mech Ageing Dev 2017 Dec 28. Epub 2017 Dec 28.
    Clinical Drug Trial Center, Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, Sichuan, P.R. China, 610081; Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, P.R. China, 610081. Electronic address:
    Objective: Endothelial cellular senescence is an important contributor to the endothelial dysfunction and atherosclerosis. Our previous studies suggested that salidroside (SAL) can alleviate atherosclerosis and protect endothelial cells against oxidative stress induced damage. However, the effect and mechanism of SAL on endothelial cellular senescence is still unclear. Read More

    The genetics of Parkinson disease.
    Ageing Res Rev 2017 Dec 26;42:72-85. Epub 2017 Dec 26.
    Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
    About 15% of patients with Parkinson disease (PD) have family history and 5-10% have a monogenic form of the disease with Mendelian inheritance. To date, at least 23 loci and 19 disease-causing genes for parkinsonism have been found, but many more genetic risk loci and variants for sporadic PD phenotype have been identified in various association studies. Investigating the mutated protein products has uncovered potential pathogenic pathways that provide insights into mechanisms of neurodegeneration in familial and sporadic PD. Read More

    Mechanisms of aging and development-A new understanding of environmental damage to the skin and prevention with topical antioxidants.
    Mech Ageing Dev 2017 Dec 26. Epub 2017 Dec 26.
    The Mount Sinai ICAHN School of Medicine, USA. Electronic address:
    Recent research has given us new insights into the molecular biology of extrinsic aging of the skin. Not only does UV irradiation directly cause photoaging of the skin, but also environmental pollutants significantly damage exposed skin by several mechanisms. Exposure to the noxious gases of air pollution with simultaneous exposure to UVA can act synergistically to initiate skin cancer. Read More

    Cortical control of upright stance in elderly.
    Mech Ageing Dev 2018 Jan 22;169:19-31. Epub 2017 Dec 22.
    Human Research Program,Johnson Space Center, NASA, Houston, TX, USA.
    This study examined differences between young and elderly volunteers in cortical involvement to human posture control during quiet stance with normal and altered sensory stimulation (Experiment-1), and biomechanical perturbations (Experiment-2). The primary focus of the first part was to monitor changes in cortical activity when unexpectedly altering the sensory conditions of upright stance, such as switching from stable (eyes open, fixed support surface) to less-stable (eyes closed, sway-referenced support surface) conditions. Our results demonstrate increased cortical activations in delta (0. Read More

    DNA methylation dynamics in aging: how far are we from understanding the mechanisms?
    Mech Ageing Dev 2017 Dec 18. Epub 2017 Dec 18.
    Department of Cellular Biotechnologies and Haematology, University of Rome 'La Sapienza', 00161 Rome, Italy. Electronic address:
    DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered. Here we discuss the current knowledge of the dynamic nature of DNA epigenome landscape in mammals, and propose putative molecular mechanisms for aging-associated DNA epigenetic changes. Read More

    Cartilage regeneration and ageing: Targeting cellular plasticity in osteoarthritis.
    Ageing Res Rev 2017 Dec 16;42:56-71. Epub 2017 Dec 16.
    CellCOM research group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, 84, 15006 A Coruña, Spain. Electronic address:
    Ageing processes play a major contributing role for the development of Osteoarthritis (OA). This prototypic degenerative condition of ageing is the most common form of arthritis and is accompanied by a general decline, chronic pain and mobility deficits. The disease is primarily characterized by articular cartilage degradation, followed by subchondral bone thickening, osteophyte formation, synovial inflammation and joint degeneration. Read More

    Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions.
    Ageing Res Rev 2017 Dec 15;42:40-55. Epub 2017 Dec 15.
    International Life Sciences Institute, Europe (ILSI Europe), Av E. Mounier 83, Box 6, 1200 Brussels, Belgium. Electronic address:
    Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated. Read More

    Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p.
    Mech Ageing Dev 2018 Jan 15;169:10-18. Epub 2017 Dec 15.
    Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. Electronic address:
    Statins are reported to exert benefits on endothelial function through a mechanism involving in prevention of endothelial senescence. This study aims to explore whether atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats or ox-LDL-treated HUVECs through a mechanism involving suppress of miR-21-5p/203a-3p expression and their downstream pathway. The rats were fed with high-fat diet to establish a hyperlipidemic model, which showed an increase in plasma lipids and endothelial senescence, accompanied by the elevation in plasma levels of miR-21-5p/203a-3p, down-regulation of Drp1 and up-regulation of p53 in the aorta of hyperlipidemic rats; these phenomena were reversed by atorvastatin. Read More

    Role of microglia-neuron interactions in diabetic encephalopathy.
    Ageing Res Rev 2017 Dec 13;42:28-39. Epub 2017 Dec 13.
    National Drug Clinical Trial Institution, The Second Affiliated Hospital, Army Medical University, Chongqing, 400037, China. Electronic address:
    In the central nervous system, the primary immune cells, the microglia, prevent pathogenic invasion as the first line of defense. Microglial energy consumption is dependent on their degree of activity. Microglia express transporters for the three primary energy substrates (glucose, fatty acids, glutamine) and regulate diabetic encephalopathy via microglia-neuron interactions. Read More

    Autobiographical memory, the ageing brain and mechanisms of psychological interventions.
    Ageing Res Rev 2017 Dec 12;42:100-111. Epub 2017 Dec 12.
    Department of Psychology, Maynooth University, Co. Kildare, Ireland. Electronic address:
    Elucidating the impact of healthy cognitive ageing and dementia on autobiographical memory (AM) may help deepen our theoretical understanding of memory and underlying neural changes. The distinction between episodic and semantic autobiographical memory is particularly informative in this regard. Psychological interventions, particularly those involving reminiscence or music, have led to differential effects on episodic and semantic autobiographical memory. Read More

    Editorial: Non-coding RNA in aging and age-associated diseases - from intracellular regulators to hormone like actions.
    Mech Ageing Dev 2017 Dec;168:1-2
    TAmiRNA GmbH, Muthgasse 18, Vienna, Austria; Christian Doppler Laboratory on Biotechnology of Skin Aging, BOKU - University of Natural Resources and Life Sciences Vienna, Muthgasse 18, Austria; Austrian Cluster for Tissue Regeneration.

    Insulin-like Growth Factor 1 (IGF-1) as a marker of cognitive decline in normal ageing: A review.
    Ageing Res Rev 2017 Dec 9;42:14-27. Epub 2017 Dec 9.
    Queensland Brain Institute, University of Queensland, Brisbane, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Queensland, Australia; National Centre for Register-based Research, Aarhus University, Denmark.
    Insulin-like Growth Factor 1 (IGF-1) and its signaling pathway play a primary role in normal growth and ageing, however serum IGF-1 is known to reduce with advancing age. Recent findings suggest IGF-1 is essential for neurogenesis in the adult brain, and this reduction of IGF-1 with ageing may contribute to age-related cognitive decline. Experimental studies have shown manipulation of the GH/GF-1 axis can slow rates of cognitive decline in animals, making IGF-1 a potential biomarker of cognition, and/or its signaling pathway a possible therapeutic target to prevent or slow age-related cognitive decline. Read More

    Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing.
    Ageing Res Rev 2017 Dec 5;42:1-13. Epub 2017 Dec 5.
    CNR Institute of Molecular Genetics, Unit of Bologna, Via di Barbiano 1/10, I-40136, Bologna, Italy; Rizzoli Orthopedic Institute, Via di Barbiano 1/10, I-40136, Bologna, Italy. Electronic address:
    Mandibuloacral dysplasia (MAD) is a rare genetic condition characterized by bone abnormalities including localized osteolysis and generalized osteoporosis, skin pigmentation, lipodystrophic signs and mildly accelerated ageing. The molecular defects associated with MAD are mutations in LMNA or ZMPSTE24 (FACE1) gene, causing type A or type B MAD, respectively. Downstream of LMNA or ZMPSTE24 mutations, the lamin A precursor, prelamin A, is accumulated in cells and affects chromatin dynamics and stress response. Read More

    Cardiomyocyte ionic currents in intact young and aged murine Pgc-1βatrial preparations.
    Mech Ageing Dev 2018 Jan 29;169:1-9. Epub 2017 Nov 29.
    Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom. Electronic address:
    Introduction: Recent studies reported that energetically deficient murine Pgc-1βhearts replicate age-dependent atrial arrhythmic phenotypes associated with their corresponding clinical conditions, implicating action potential (AP) conduction slowing consequent upon reduced AP upstroke rates.

    Materials And Methods: We tested a hypothesis implicating Nacurrent alterations as a mechanism underlying these electrophysiological phenotypes. We applied loose patch-clamp techniques to intact young and aged, WT and Pgc-1β, atrial cardiomyocyte preparations preserving their in vivo extracellular and intracellular conditions. Read More

    Ferrosenescence: The iron age of neurodegeneration?
    Mech Ageing Dev 2017 Nov 24. Epub 2017 Nov 24.
    Loma Linda University, Loma Linda, CA, United States. Electronic address:
    Aging has been associated with iron retention in many cell types, including the neurons, promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by damaging the DNA and blocking genomic repair systems, a process we define as ferrosenescence. Novel neuroimaging and proteomic techniques have pinpointed indicators of both iron retention and ferrosenescence, allowing for their early correction, potentially bringing prevention of neurodegenerative disorders within reach. Read More

    Effect of polyphenols from coffee and grape on gene expression in myoblasts.
    Mech Ageing Dev 2017 Nov 23. Epub 2017 Nov 23.
    Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, 41221, Greece. Electronic address:
    Coffee and grape contain various bioactive compounds like polyphenols that may exert beneficial effects, especially antioxidant activity, on human health upon consumption. However, the molecular mechanisms through which these effects are achieved are not fully elucidated. Thus, in the present study in order to investigate these mechanisms, a whole genome expression DNA microarray analysis was carried out in myoblasts treated with polyphenols of coffee and grape pomace at concentrations that improved the redox status. Read More

    The role of epigenetics in cardiovascular health and ageing: A focus on physical activity and nutrition.
    Mech Ageing Dev 2017 Nov 16. Epub 2017 Nov 16.
    School of Health & Human Performance, Dublin City University, Ireland; Centre for Preventive Medicine, Dublin City University, Ireland.
    The cardiovascular system is responsible for transport of blood and nutrients to tissues, and is pivotal to the physiological health and longevity. Epigenetic modification is a natural, age-associated process resulting in highly contextualised gene expression with clear implications for cell differentiation and disease onset. Biological/epigenetic age is independent of chronological age, constituting a highly reflective snapshot of an individual's overall health. Read More

    Effects of different hypoxia degrees on endothelial cell cultures-Time course study.
    Mech Ageing Dev 2017 Nov 15. Epub 2017 Nov 15.
    University of Medicine and Pharmacy, Department of Physiology, Clinicilor 1, Cluj-Napoca, Romania. Electronic address:
    Introduction: Exposure of the endothelial cells to hypoxia, the decrease in oxygen supply can trigger an endothelial response. This response is involved in inflammatory diseases, tumorigenesis, and also with the micro vascular damage associated with aging. The aim of our study was to determine the hypoxia/re-oxygenation induced response in vitro, using human umbilical vein endothelial cells (HUVEC) cultures, at different time points with focus on cell viability, apoptosis oxidative stress and angiogenesis stimulation. Read More

    Age influences the skin reaction pattern to mechanical stress and its repair level through skin care products.
    Mech Ageing Dev 2017 Nov 21. Epub 2017 Nov 21.
    Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy.
    Skin aging is associated with alterations of surface texture, sebum composition and immune response. Mechanical stress induces repair mechanisms, which may be dependent on the age and quality of the skin. The response to mechanical stress in young and aged individuals, their subjective opinion and the objective effectiveness of skin care products were evaluated by biophysical skin quality parameters (stratum corneum hydration, transepidermal water loss, skin pH, pigmentation and erythema) at baseline, 1, 6, 24h and 7days at the forearms of 2 groups of healthy volunteers, younger than 35 years (n=11) and older than 60 years (n=13). Read More

    Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases.
    Ageing Res Rev 2018 Jan 14;41:82-97. Epub 2017 Nov 14.
    Departments of Pathology and Genome Sciences, University of Washington, Seattle, WA 98195, USA.
    Werner syndrome (WS) is a heritable autosomal recessive human disorder characterized by the premature onset of several age-associated pathologies including cancer. The protein defective in WS patients, WRN, is encoded by a member of the human RECQ gene family that contains both a DNA exonuclease and a helicase domain. WRN has been shown to participate in several DNA metabolic pathways including DNA replication, recombination and repair, as well as telomere maintenance and transcription modulation. Read More

    'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age.
    Mech Ageing Dev 2018 Jan 14;169:53-62. Epub 2017 Nov 14.
    Institute for Cell and Molecular Biosciences (ICaMB), Ageing Research Laboratories, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne, NE4 5PL,United Kingdom; MRC/Arthritis Research UK Centre for Musculoskeletal Ageing (CIMA), United Kingdom. Electronic address:
    The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. Read More

    FOXO1/3: Potential suppressors of fibrosis.
    Ageing Res Rev 2018 Jan 11;41:42-52. Epub 2017 Nov 11.
    Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China. Electronic address:
    Fibrosis is a universally age-related disease that involves nearly all organs. It is typically initiated by organic injury and eventually results in organ failure. There are still few effective therapeutic strategy targets for fibrogenesis. Read More

    Autoamplificatory singlet oxygen generation sensitizes tumor cells for intercellular apoptosis-inducing signaling.
    Mech Ageing Dev 2017 Nov 11. Epub 2017 Nov 11.
    Institute of Virology, Medical Center - University of Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:
    Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase.

    Treatment: of tumor cells with high concentrations of HO, peroxnitrite, HOCl, or increasing the concentration of cell-derived NO causes initial generation of singlet oxygen and local inactivation of membrane-associated catalase. As a result, free peroxynitrite and HOinteract and generate secondary singlet oxygen. Read More

    The role of TGFβ in wound healing pathologies.
    Mech Ageing Dev 2017 Nov 11. Epub 2017 Nov 11.
    Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
    Wound healing is one of the most complex processes in multicellular organisms, involving numerous intra- and intercellular signalling pathways in various cell types. It involves extensive communication between the cellular constituents of diverse skin compartments and its extracellular matrix. Miscommunication during healing may have two distinct damaging consequences: the development of a chronic wound or the formation of a hypertrophic scar/keloid. Read More

    Connecting chaperone-mediated autophagy dysfunction to cellular senescence.
    Ageing Res Rev 2018 Jan 4;41:34-41. Epub 2017 Nov 4.
    Department of Neurodevelopment and Physiology, Institute of Cellular Physiology, National Autonomous University of México (UNAM), Mexico City, Mexico. Electronic address:
    Chaperone-mediated autophagy (CMA) is one of the main pathways of the lysosome-autophagy proteolytic system. It regulates different cellular process through the selective degradation of cytosolic proteins. In ageing, the function of CMA is impaired causing an inefficient stress response and the accumulation of damaged, oxidized or misfolded proteins, which is associated with numerous age-related diseases. Read More

    Oxidative stress in ageing and disease development studied by FT-IR spectroscopy.
    Mech Ageing Dev 2017 Nov 4. Epub 2017 Nov 4.
    National Technical University of Athens, Chemical Engineering Department, Radiation Chemistry & Biospectroscopy, Zografou Campus, 15780, Athens, Greece.
    FT-IR spectroscopy was used to investigate the effect of oxidative stress and to approach the mechanism on cancer bone demineralization, aortic valve mineralization and heterotopic ossification on disease development. The FT-IR spectra obtained from paediatric, adult bone and ex vivo irradiated adult healthy bone with a dose of 20Gy were compared with those of healthy bone. The increase of band intensity changes of vasCHvsCHin the region 3000-2850cmdepended on aging, the disease progression and the dose of irradiation. Read More

    The role of cellular senescence in aging through the prism of Koch-like criteria.
    Ageing Res Rev 2018 Jan 26;41:18-33. Epub 2017 Oct 26.
    The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel. Electronic address:
    Since Hayflick's discovery of cellular senescence (CS), a great volume of knowledge in the field has been accumulated and intensively discussed. Here, we attempted to organize the evidence "for" and "against" the hypothesized causal role of CS in aging. For that purpose, we utilized robust Koch-like logical criteria, based on the assumption that some quantitative relationships between the accumulation of senescent cells and aging rate should exist. Read More

    Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure.
    Mech Ageing Dev 2017 Nov 8. Epub 2017 Nov 8.
    Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Department of Animal Science, North Carolina State University, Plants for Human Health Institute, NC Research Center, 28081, Kannapolis NC, USA. Electronic address:
    Epidemiological evidences have correlated airbone particulate matter (PM) to adverse health effects, mainly linking to pulmonary and cardiovascular disease. Nevertheless, only recently, some studies reported detrimental effects of PM on other organs such as skin. In a recent work, we have reported increased oxidative and inflammatory responses in Reconstituted Human Epidermis (RHE) exposed to ambient particles (CAPs) and we also demonstrated the ability of CAPs to penetrate the skin tissue. Read More

    OLR1 scavenger receptor knockdown affects mitotic gene expression but is dispensable for oxidized phospholipid- mediated stress signaling in SZ 95 sebocytes.
    Mech Ageing Dev 2017 Nov 20. Epub 2017 Nov 20.
    Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, Leitstelle 7J, A-1090 Vienna, Austria; Christian Doppler Laboratory for Biotechnology of Skin Aging, Austria. Electronic address:
    Phospholipid oxidation products (OxPL) are versatile stress signaling mediators in the skin. These lipid signaling molecules can be generated non-enzymatically or enzymatically by ultraviolet light, the major extrinsic skin aging factor. OxPL regulate cytoprotective, immunological and metabolic adaptation of the skin to oxidant stress. Read More

    p38 but not p53 is responsible for UVA-induced MCPIP1 expression.
    Mech Ageing Dev 2017 Nov 15. Epub 2017 Nov 15.
    Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Krakow, Poland. Electronic address:
    MCPIP1 (Monocyte Chemotactic Protein-1 Induced Protein) is an important regulator of inflammation and cell apoptosis, but its role in UVA-induced stress response in the epidermis has never been studied. We have found that moderate apoptosis-inducing dose of UVA (27J/cm) increases the level of MCPIP1 expression in HaCaT cells and normal human keratinocytes (NHEK) within 6-9h after the treatment. MCPIP1 upregulation was dependent on the induction of p38, but not p53, as demonstrated by using p38 inhibitor SB203580 and p53 inducer RG7388, respectively. Read More

    Phagocyte NADPH oxidase, oxidative stress and lipids: Anti- or pro ageing?
    Mech Ageing Dev 2017 Nov 9. Epub 2017 Nov 9.
    Laboratoire de Chimie Physique, Université Paris Sud, UMR 8000, CNRS, 91405, Orsay Cedex, France. Electronic address:
    The role of NADPH oxidase in ageing is debated because of the dual roles of free radicals, toxic though necessary. In this paper we summarize some results about two aspects linked to the regulation of the activity of phagocyte NADPH oxidase (Nox2), encountered frequently in elderly people: inflammation and hypercholesterolemia. In the presence of a high amount of reactive oxygen species (ROS) created by itself or by any other source, the enzyme activity is mostly lowered. Read More

    Differential gene expression analysis in ageing muscle and drug discovery perspectives.
    Ageing Res Rev 2018 Jan 2;41:53-63. Epub 2017 Nov 2.
    CREMI, CHU de Québec Research Center, Quebec, Quebec, G1V 4G2, Canada; Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Quebec, G1V 4G2, Canada. Electronic address:
    Identifying therapeutic target genes represents the key step in functional genomics-based therapies. Within this context, the disease heterogeneity, the exogenous factors and the complexity of genomic structure and function represent important challenges. The functional genomics aims to overcome such obstacles via identifying the gene functions and therefore highlight disease-causing genes as therapeutic targets. Read More

    Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs "in vitro" wound closure.
    Mech Ageing Dev 2017 Nov 1. Epub 2017 Nov 1.
    Dept. of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Plants for Human Health Institute, Animal Sciences Dept., NC Research Campus, NC State University, NC, USA. Electronic address:
    Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids levels. Among the tissues where it is localized, SR-B1 has been shown to be significantly expressed in human epidermis. Read More

    The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE).
    Ageing Res Rev 2018 Jan 31;41:64-81. Epub 2017 Oct 31.
    Incyte Corporation, Wilmington, DA, USA. Electronic address:
    The human ageing process encompasses mechanisms that effect a decline in homeostasis with increased susceptibility to disease and the development of chronic life-threatening illness. Increasing age affects the immune system which undergoes a progressive loss of efficiency, termed immunosenescence (ISC), to impact on quantitative and functional aspects of innate and adaptive immunity. The human demyelinating disease multiple sclerosis (MS) and the corresponding animal model experimental autoimmune encephalomyelitis (EAE) are strongly governed by immunological events that primarily involve the adaptive arm of the immune response. Read More

    Centenarians as a model to discover genetic and epigenetic signatures of healthy ageing.
    Mech Ageing Dev 2017 Oct 30. Epub 2017 Oct 30.
    Department of Pathobiology and Medical Biotechnologies, University of Palermo, 90134 Palermo, Italy.
    Centenarians are a model of successful ageing. The data favours the theory that, in order to live to 100, it is mandatory to inherit the right genetic variants from parents or acquire epigenetic variants through the environment. Therefore, the study of epigenetic signatures of healthy ageing is becoming an important aspect to identify the role of chromatin modification in ageing and understand how manage this fine-tuning system. Read More

    Inflammageing and metaflammation: The yin and yang of type 2 diabetes.
    Ageing Res Rev 2018 Jan 31;41:1-17. Epub 2017 Oct 31.
    Department of Cardiovascular Research, IRCCS MultiMedica, Milan, MI, Italy; Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
    Type 2 diabetes mellitus (T2DM) is characterised by chronic low-grade inflammation, recently referred to as 'metaflammation', a relevant factor contributing to the development of both diabetes and its complications. Nonetheless, 'canonical' anti-inflammatory drugs do not yield satisfactory results in terms of prevention of diabetes progression and of cardiovascular events, suggesting that the causal mechanisms fostering metaflammation deserve further research to identify new druggable targets. Metaflammation resembles ageing-induced low-grade inflammation, previously referred to as inflammageing, in terms of clinical presentation and the molecular profile, pointing to a common aetiology for both conditions. Read More

    Alzheimer's disease pathogenesis: Is there a role for folate?
    Mech Ageing Dev 2017 Oct 13. Epub 2017 Oct 13.
    Academic Urology Unit, Department of Oncology and Metabolism, University of Sheffield, United Kingdom.
    Epigenetic modifications, including changes in DNA methylation, have been implicated in a wide range of diseases including neurological diseases such as Alzheimer's. The role of dietary folate in providing methyl groups required for maintenance and modulation of DNA methylation makes it a nutrient of interest in Alzheimer's. Late onset Alzheimer's disease is the most common form of dementia and at present its aetiology is largely undetermined. Read More

    Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort.
    Mech Ageing Dev 2017 Oct 9;167:56-63. Epub 2017 Oct 9.
    Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00, Brno, Czech Republic; Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Kamenice 5, Building A29, 625 00, Brno, Czech Republic.
    Aging may be characterized as the progressive increase of the risk of death caused by a decrease of almost all bodily functions. While a great number of model organism studies have established the role of DNA double strand breaks (DSBs) as one of the main causes of aging, few studies have examined whether common polymorphisms in human DSB repair genes influence aging and mortality. More importantly, to the best of our knowledge, no longitudinal study has thus far examined the link between polymorphisms in DSB repair and the risk of death. Read More

    Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy.
    Ageing Res Rev 2017 Nov 7;40:142-148. Epub 2017 Oct 7.
    Dept. Communication Sciences & Disorders, 4202 E. Fowler Avenue, PCD1017 University of South Florida, Tampa, FL 33620-8200, USA; Global Center for Hearing & Speech Res., 3802 Spectrum Blvd., BPB Suite 210, University of South Florida Res. Park, Tampa, FL 33612, USA; Dept. Chemical & Biomedical Engineering, 4202 E Fowler Avenue, ENB 118 University of South Florida, Tampa, FL 33620, USA. Electronic address:
    Chronic, low-grade inflammation, or inflammaging, is a crucial contributor to various age-related pathologies and natural processes in aging tissue, including the nervous system. Over the past two decades, much effort has been done to understand the mechanisms of inflammaging in disease models such as type II diabetes, cardiovascular disease, Alzheimer's disease, Parkinson's disease, and others. However, despite being the most prevalent neurodegenerative disorder, the number one communication disorder, and one of the top three chronic medical conditions of our aged population; little research has been conducted on the potential role of inflammation in age-related hearing loss (ARHL). Read More

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