5,516 results match your criteria Ageing Research Reviews [Journal]


The ING1a model of rapid cell senescence.

Mech Ageing Dev 2018 Jun 18. Epub 2018 Jun 18.

Arnie Charbonneau Cancer Institute, Departments of Biochemistry and Molecular Biology and Oncology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada. Electronic address:

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June 2018
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Nrf2: Molecular and epigenetic regulation during aging.

Ageing Res Rev 2018 Jun 18;47:31-40. Epub 2018 Jun 18.

Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de Mexico, 09340, Mexico. Electronic address:

Increase in life-span is commonly related with age-related diseases and with gradual loss of genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived factor 2) controls the expression of genes whose products include antioxidant proteins, detoxifying enzymes, drug transporters and numerous cytoprotective proteins. Several experimental approaches have evaluated the potential regulation of the transcription factor Nrf2 to enhance the expression of genes that contend against accumulative oxidative stress and promote healthy aging. Read More

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Cancer-free aging: Insights from Spalax ehrenbergi superspecies.

Ageing Res Rev 2018 Jun 15;47:18-23. Epub 2018 Jun 15.

Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Av. Instituto Politécnico Nacional No. 2508, San Pedro Zacatenco, Gustavo A. Madero, 07360, Mexico City, Mexico. Electronic address:

Cancer and ageing can be regarded as two different manifestations of the same underlying process-accumulation of cellular damage-and therefore both are closely linked. Nowadays, the ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities, and therefore the understanding of links between cancer and ageing is more important than ever. Spalax is considered an excellent model for ageing and, additionally, for cancer research, due to not show clear age-related phenotypic changes and not develop spontaneous tumours, despite its relatively long lifespan (∼20 years in captivity). Read More

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Genome-wide profiling of adult human papillary and reticular fibroblasts identifies ACAN, Col XI α1, and PSG1 as general biomarkers of dermis ageing, and KANK4 as an exemplary effector of papillary fibroblast ageing, related to contractility.

Mech Ageing Dev 2018 Jun 15. Epub 2018 Jun 15.

(a)Advanced Research, L'Oréal Research and Innovation, 93600, Aulnay-sous-Bois, France.

Deciphering the characteristics of dermal fibroblasts is critical to further understand skin ageing. We have conducted a genome-wide transcriptomic characterization of papillary (Fp) and reticular (Fr) fibroblasts extracted from human skin samples corresponding to younger and older adult ages. From this screen, biomarkers suitable for the assessment of chronological ageing were identified, and extrapolated to the context of photo-damaged skin. Read More

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Divergent mechanisms of metabolic dysfunction drive fibroblast and T-cell senescence.

Ageing Res Rev 2018 Jun 15;47:24-30. Epub 2018 Jun 15.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. Electronic address:

The impact of cellular senescence during ageing is well established, however senescence is now recognised to play a role in a variety of age related and metabolic diseases, such as cancer, autoimmune and cardiovascular diseases. It is therefore crucial to gain a better understanding of the mechanisms that control cellular senescence. In recent years our understanding of the intimate relationship between cell metabolism, cell signalling and cellular senescence has greatly improved. Read More

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Cerebral small vessel disease and the risk of Alzheimer's disease: A systematic review.

Ageing Res Rev 2018 Jun 10. Epub 2018 Jun 10.

(a)Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia; (e)Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Sydney, Australia.

Background: Cerebral small vessel disease (CSVD) comprises a variety of disorders affecting small arteries and microvessels of the brain, manifesting as white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and deep brain infarcts. In addition to its contribution to vascular dementia (VaD), it has also been suggested to contribute to the pathogenesis of Alzheimer's disease (AD).

Method: A systematic review of the literature available on Medline, Embase and Pubmed was undertaken, whereby CSVD was divided into WMHs, CMBs and deep brain infarcts. Read More

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Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity.

Mech Ageing Dev 2018 Jun 8. Epub 2018 Jun 8.

(a)Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia. Electronic address:

Background: Many factors contribute to exceptional longevity, with genetics playing a significant role. However, to date, genetic studies examining exceptional longevity have been inconclusive. This comprehensive review seeks to determine the genetic variants associated with exceptional longevity by undertaking meta-analyses. Read More

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Role of human oocyte-enriched factors in somatic cell reprograming.

Mech Ageing Dev 2018 Jun 8. Epub 2018 Jun 8.

Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, Egypt. Electronic address:

Cellular reprograming paves the way for creating functional patient-specific tissues to eliminate immune rejection responses by applying the same genetic profile. However, the epigenetic memory of a cell remains a challenge facing the current reprograming methods and does not allow transcription factors to bind properly. Because somatic cells can be reprogramed by transferring their nuclear contents into oocytes, introducing specific oocyte factors into differentiated cells is considered a promising approach for mimicking the reprograming process that occurs during fertilization. Read More

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NAD metabolism: Implications in aging and longevity.

Ageing Res Rev 2018 Jun 5;47:1-17. Epub 2018 Jun 5.

Frontier Research Core for Life Sciences, University of Toyama, Toyama, 930-0194, Japan; Department of Metabolism and Nutrition, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, 930-0194, Japan; Institute of Natural Medicine, University of Toyama, Toyama, 930-0194, Japan. Electronic address:

Nicotinamide adenine dinucleotide (NAD) is an important co-factor involved in numerous physiological processes, including metabolism, post-translational protein modification, and DNA repair. In living organisms, a careful balance between NAD production and degradation serves to regulate NAD levels. Recently, a number of studies have demonstrated that NAD levels decrease with age, and the deterioration of NAD metabolism promotes several aging-associated diseases, including metabolic and neurodegenerative diseases and various cancers. Read More

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From fetus to older age: A review of brain metabolic changes across the lifespan.

Ageing Res Rev 2018 Jun 1;46:60-73. Epub 2018 Jun 1.

Jagiellonian University, Faculty of Management and Social Communication, Institute of Applied Psychology, Department of Cognitive Neuroscience, Kraków, Poland; SWPS University of Social Sciences and Humanities, Institute of Psychology, Warszawa, Poland. Electronic address:

Introduction: The knowledge of metabolic changes across the lifespan is poorly understood. Thus we systematically reviewed the available literature to determine the changes in brain biochemical composition from fetus to older age and tried to explain them in the context of neural, cognitive, and behavioural changes.

Methods: The search identified 1262 articles regarding proton magnetic resonance spectroscopy (1H MRS) examinations through December 2017. Read More

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Improving the comprehension of sarcopenic state determinants: An multivariate approach involving hormonal, nutritional, lifestyle and genetic variables.

Mech Ageing Dev 2018 Jul 25;173:21-28. Epub 2018 May 25.

Integrative Physiology Research Center, Department of Biological Sciences, State University of Southwest Bahia (UESB), Jequie, 45210-506, Bahia, Brazil; Postgraduate Program in Nursing & Health, State University of Southwest Bahia (UESB), Jequie, 45210-506, Bahia, Brazil; Human Genetics Laboratory, Department of Biological Sciences, State University of Southwest Bahia (UESB), Jequie, 45210-506, Bahia, Brazil. Electronic address:

It is known that sarcopenia is a multifaceted phenomenon, which involves genetic, nutritional, hormonal and living habits aspects. Then, an integrated analysis, as a multivariate approach, could improve the comprehension about the determinants of sarcopenic state in old adults. The present study aimed to investigate the interaction among serum vitamin D, daily caloric and protein intake, lifestyle habits, ACE I/D gene polymorphism and sarcopenic state in community-dwelling old adults. Read More

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Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.

Ageing Res Rev 2018 May 25;46:42-59. Epub 2018 May 25.

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, United States; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States.

Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism underlying the aging process. Some biological and pharmaceutical compounds may reduce systemic inflammation and potentially avert functional decline occurring with aging. The aim of the present meta-analysis was to examine the association of pre-selected interventions on two established biomarkers of inflammation, interleukin-6 (IL-6), and C-reactive protein (CRP) in middle-age and older adults with chronic LGI. Read More

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O-GlcNAcylation and neuronal energy status: Implications for Alzheimer's disease.

Ageing Res Rev 2018 May 19;46:32-41. Epub 2018 May 19.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Laboratory of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. Electronic address:

Since the first clinical case reported more than 100 years ago, it has been a long and winding road to demystify the initial pathological events underling the onset of Alzheimer's disease (AD). Fortunately, advanced imaging techniques extended the knowledge regarding AD origin, being well accepted that a decline in brain glucose metabolism occurs during the prodromal phases of AD and is aggravated with the progression of the disease. In this sense, in the last decades, the post-translational modification O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) has emerged as a potential causative link between hampered brain glucose metabolism and AD pathology. Read More

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To adapt or not to adapt: Consequences of declining Adaptive Homeostasis and Proteostasis with age.

Mech Ageing Dev 2018 May 17. Epub 2018 May 17.

Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, the University of Southern California, Los Angeles, CA, 00089-0191, USA; Molecular & Computational Biology Program of the Department of Biological Sciences, Dornsife College of Letters, Arts, and sciences, the University of Southern California, Los Angeles, CA, 90089-0191, USA; Department of Biochemistry & Molecular Medicine, Keck School of Medicine of USC, the University of Southern California, Los Angeles, CA, USA. Electronic address:

Many consequences of ageing can be broadly attributed to the inability to maintain homeostasis. Multiple markers of ageing have been identified, including loss of protein homeostasis, increased inflammation, and declining metabolism. Although much effort has been focused on characterization of the ageing phenotype, much less is understood about the underlying causes of ageing. Read More

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Major traits of the senescent phenotype of nucleus pulposus intervertebral disc cells persist under the specific microenvironmental conditions of the tissue.

Mech Ageing Dev 2018 May 17. Epub 2018 May 17.

Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", Athens, Greece. Electronic address:

Intervertebral discs (IVDs) are the joints of the spine, mainly consisting of extracellular matrix (ECM) with a low number of cells embedded therein. Low cellularity stems from nutrient deprivation due to the lack of blood supply, as well as from the hypoxic and hyperosmotic conditions prevailing in the tissue. Intervertebral disc degeneration (IDD) has been firmly connected with low back pain, a major age-related disease, whereas degenerated discs have been characterized by increased proteolytic activity and accumulation of senescent cells. Read More

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Epigenetics in ageing and development.

Mech Ageing Dev 2018 May 17. Epub 2018 May 17.

Advanced Technology Center for Aging Research, Scientific and Technological Pole, Italian National Institute of Health and Science on Aging (INRCA), Ancona, Italy.

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Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β) murine hearts.

Mech Ageing Dev 2018 Jul 12;173:92-103. Epub 2018 May 12.

Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom. Electronic address:

Introduction: Ageing and age-related bioenergetic conditions including obesity, diabetes mellitus and heart failure constitute clinical ventricular arrhythmic risk factors.

Materials And Methods: Pro-arrhythmic properties in electrocardiographic and intracellular recordings were compared in young and aged, peroxisome proliferator-activated receptor-γ coactivator-1β knockout (Pgc-1β) and wild type (WT), Langendorff-perfused murine hearts, during regular and programmed stimulation (PES), comparing results by two-way ANOVA.

Results And Discussion: Young and aged Pgc-1β showed higher frequencies and durations of arrhythmic episodes through wider PES coupling-interval ranges than WT. Read More

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Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice.

Mech Ageing Dev 2018 Jul;173:84-91

Trinity College Institute for Neuroscience, Trinity College, Dublin 2, Ireland. Electronic address:

The recognized role of neuroinflammation in the age-related deterioration of neuronal function highlights the importance of understanding the factors that control microglial activation. Microglia, as the immune cells of the brain, are the arbiters of the inflammatory profile in the brain. Normally they are maintained in a quiescent state by means of ligand-receptor interactions with neurons, within a prevailing anti-inflammatory microenvironment. Read More

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July 2018
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CircRNA accumulation: A new hallmark of aging?

Mech Ageing Dev 2018 Jul 16;173:71-79. Epub 2018 May 16.

Department of Biology, University of Nevada, Reno, Nevada 89557, United States. Electronic address:

Circular RNAs (circRNAs) are a newly appreciated class of RNAs found across phyla that are generated most commonly from back-splicing of protein-coding exons. Recent profiling of circRNAs genome-wide has shown that hundreds of circRNAs dramatically increase in expression during aging in the brains of multiple organisms. No other class of transcripts has been found to show such a strong correlation with aging as circRNAs-could they be playing a role in the aging process? Here, we discuss the different methods used to profile circRNAs and discuss current limitations of these approaches. Read More

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RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting.

Mech Ageing Dev 2018 Jul 9;173:80-83. Epub 2018 May 9.

Department of Clinical Cell Biology and Medicine, Chiba University, Graduate School of Medicine, Chiba, Japan.

Progeroid syndrome is a group of disorders characterized by the early onset of diseases that are associated with aging. Best known examples are Werner syndrome, which is adult onset and results from disease-causing DNA sequence variants in the RecQ helicase gene WRN, and Hutchison-Gilford progeria syndrome, which is childhood-onset and results from unique, recurrent disease-causing DNA sequence variants of the gene LMNA that encodes nuclear intermediate filaments. Related single gene RecQ disorders are Bloom syndrome and Rothmund-Thomson syndrome. Read More

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July 2018
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Anti-senescence compounds: A potential nutraceutical approach to healthy aging.

Ageing Res Rev 2018 May 6;46:14-31. Epub 2018 May 6.

Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, INRCA-IRCCS National Institute, Ancona, Italy. Electronic address:

The desire of eternal youth seems to be as old as mankind. However, the increasing life expectancy experienced by populations in developed countries also involves a significantly increased incidence of the most common age-related diseases (ARDs). Senescent cells (SCs) have been identified as culprits of organismal aging. Read More

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Muscle plasticity of aged subjects in response to electrical stimulation training and inversion and/or limitation of the sarcopenic process.

Authors:
Thierry Paillard

Ageing Res Rev 2018 May 6;46:1-13. Epub 2018 May 6.

Laboratoire Mouvement, Equilibre, Performance et Santé, EA 4445, Université de Pau et des Pays de l'Adour, Département STAPS, ZA Bastillac Sud, 65000 Tarbes, France. Electronic address:

This review addresses the possible structural and functional adaptations of the muscle function to neuromuscular electrical stimulation (NMES) training in frail and/or aged (without advanced chronic disease) subjects. Evidence suggests that the sarcopenic process and its structural and functional effects would be limited and/or reversed through NMES training using excito-motor currents (or direct currents). From a structural viewpoint, NMES helps reduce muscle atrophy. Read More

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Role of hypothalamus in aging and its underlying cellular mechanisms.

Mech Ageing Dev 2018 May 2. Epub 2018 May 2.

Department of Brain and Cognitive Sciences, DGIST, Daegu, 42988, Republic of Korea. Electronic address:

Aging is characterized by a progressive loss of several physiological functions that can cause various age-related disorders. Several factors have been identified as causes of aging to elucidate the decline in functions. Various aspects of physiological deterioration are controlled by the hypothalamus, a critical brain region that connects the neuroendocrine system to physiological functions. Read More

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Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study.

Mech Ageing Dev 2018 Apr 30. Epub 2018 Apr 30.

National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Frailty among elderly people leads to an increased risk for negative health outcomes. To prevent frailty, we need a better understanding of the underlying mechanisms and early detection of individuals at risk. Both may be served by identifying candidate (bio)markers, i. Read More

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April 2018
2 Reads

Muscle morphology and performance in master athletes: A systematic review and meta-analyses.

Ageing Res Rev 2018 Apr 30;45:62-82. Epub 2018 Apr 30.

School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, UK; MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, B15 2TT, UK.

Introduction: The extent to which chronic exercise training preserves age-related decrements in physical function, muscle strength, mass and morphology is unclear. Our aim was to conduct a systematic review of the literature to determine to what extent chronically trained master athletes (strength/power and endurance) preserve levels of physical function, muscle strength, muscle mass and morphology in older age, compared with older and younger controls and young trained individuals.

Methods: The systematic data search included Medline, EMBASE, SPORTDiscus, CINAHL and Web of Science databases. Read More

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Dysbiosis of gut microbiota and microbial metabolites in Parkinson's Disease.

Ageing Res Rev 2018 Apr 26;45:53-61. Epub 2018 Apr 26.

Wuxi Medical School, Jiangnan University, Jiangsu, 214122, Wuxi, China. Electronic address:

Gut microbial dysbiosis and alteration of microbial metabolites in Parkinson's disease (PD) have been increasingly reported. Dysbiosis in the composition and abundance of gut microbiota can affect both the enteric nervous system and the central nervous system (CNS), indicating the existence of a microbiota-gut-brain axis and thereby causing CNS diseases. Disturbance of the microbiota-gut-brain axis has been linked to specific microbial products that are related to gut inflammation and neuroinflammation. Read More

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Drosophila pericardial nephrocyte ultrastructure changes during ageing.

Mech Ageing Dev 2018 Jul 24;173:9-20. Epub 2018 Apr 24.

Department of Zoology and Developmental Biology, University of Osnabrück, 49076 Osnabrück, Barbarastraße 11, Germany. Electronic address:

Here we show that a labyrinth channel compartment and slit diaphragms, which are the histological structures enabling insect nephrocytes ultrafiltration, are established during embryogenesis first by the garland nephrocytes (GCNs). The later pericardial nephrocytes, which represent the majority of functional nephrocytes in larvae and adults, lack these characteristic features at the embryonic stage. During larval development, a subpopulation of the pericardial cells survives and matures into functional nephrocytes (PCNs) displaying a fully differentiated slit diaphragm and a labyrinth channel compartment. Read More

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July 2018
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Multi-tissue DNA methylation age: Molecular relationships and perspectives for advancing biomarker utility.

Ageing Res Rev 2018 Apr 23;45:15-23. Epub 2018 Apr 23.

Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.

The multi-tissue DNA methylation estimator of chronological age (DNAm-age) has been associated with a wide range of exposures and health outcomes. Still, it is unclear how DNAm-age can have such broad relationships and how it can be best utilized as a biomarker. Understanding DNAm-age's molecular relationships is a promising approach to address this critical knowledge gap. Read More

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April 2018
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Prenatal exposure to oxidative phosphorylation xenobiotics and late-onset Parkinson disease.

Ageing Res Rev 2018 Apr 22;45:24-32. Epub 2018 Apr 22.

Departamento de Bioquímica, Biología Molecular y Celular, Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, Spain; Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, Spain; Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, Spain; Fundación ARAID, Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, Spain. Electronic address:

Late-onset Parkinson disease is a multifactorial and multietiological disorder, age being one of the factors implicated. Genetic and/or environmental factors, such as pesticides, can also be involved. Up to 80% of dopaminergic neurons of the substantia nigra are lost before motor features of the disorder begin to appear. Read More

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Effective multicomponent interventions in comparison to active control and no interventions on physical capacity, cognitive function and instrumental activities of daily living in elderly people with and without mild impaired cognition - A systematic review and network meta-analysis.

Ageing Res Rev 2018 Apr 18;45:1-14. Epub 2018 Apr 18.

University of Applied Sciences Zurich, Institute of Physiotherapy, Technikumstrasse 71, CH-8400 Winterthur, Switzerland.

Multicomponent interventions (MCT) combine physical exercises and cognitive training and seem to be most effective in improving cognition in elderly people. However, literature is inconclusive if MCTs are superior to active comparison interventions, if delivery modes matter, and if people can transfer achieved effects to instrumental activities of daily living (IADL). This network meta-analysis aimed to a) identify MCTs that were effective on physical capacity and/or cognitive function and able to transfer these effects into IADL in elderly people with normal cognition (NC) and mild cognitive impairment (MCI); b) provide a rating on the best interventions per outcome; c) evaluate MCTs' mode of delivery. Read More

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April 2018
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Epigenetic and non-epigenetic functions of the RYBP protein in development and disease.

Mech Ageing Dev 2018 Apr 14. Epub 2018 Apr 14.

Centro de Biología Molecular "Severo Ochoa" CSIC-UAM, Nicolás Cabrera 1, 28049, Madrid, Spain. Electronic address:

Over the last decades significant advances have been made in our understanding of the molecular mechanisms controlling organismal development. Among these mechanisms the knowledge gained on the roles played by epigenetic regulation of gene expression is extensive. Epigenetic control of transcription requires the function of protein complexes whose specific biochemical activities, such as histone mono-ubiquitylation, affect chromatin compaction and, consequently activation or repression of gene expression. Read More

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April 2018
3 Reads

Immune signatures associated with mortality differ in elderly populations from different birth cohorts and countries even within northern Europe.

Authors:
Graham Pawelec

Mech Ageing Dev 2018 Apr 11. Epub 2018 Apr 11.

Second Department of Internal Medicine, University of Tübingen, Tübingen, Germany; Health Sciences North Research Institute of Canada, Sudbury, ON, Canada. Electronic address:

Since associations between lifespan and certain simple immune parameters such as T cell proliferative responses to mitogens were reported in the 1970´s, efforts to dissect out immune parameters correlating with morbidity and mortality have sought to define factors predicting individual longevity. Such "immune signatures" associating with defined clinical outcomes would represent biomarkers of "immunosenescence" that might also provide mechanistic insights into the ageing process. Because appropriate immune function is necessary for a healthy old age, a better understanding of immunosenescence contributing to frailty and death might allow interventions to improve personal and public health. Read More

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April 2018
2 Reads

The multiple functions of melatonin in regenerative medicine.

Ageing Res Rev 2018 Apr 6;45:33-52. Epub 2018 Apr 6.

Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Melatonin research has been experiencing hyper growth in the last two decades; this relates to its numerous physiological functions including anti-inflammation, oncostasis, circadian and endocrine rhythm regulation, and its potent antioxidant activity. Recently, a large number of studies have focused on the role of melatonin in the regeneration of cells or tissues after their partial loss. In this review, we discuss the recent findings on the molecular involvement of melatonin in the regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others. Read More

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April 2018
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Auditory system dysfunction in Alzheimer disease and its prodromal states: A review.

Ageing Res Rev 2018 Jul 6;44:49-59. Epub 2018 Apr 6.

University of Illinois College of Medicine, United States; Neuroscience Program, University of Illinois at Urbana-Champaign, United States; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, United States; Beckman Institute for Advanced Science and Technology, Urbana, IL, United States. Electronic address:

Recent findings suggest that both peripheral and central auditory system dysfunction occur in the prodromal stages of Alzheimer Disease (AD), and therefore may represent early indicators of the disease. In addition, loss of auditory function itself leads to communication difficulties, social isolation and poor quality of life for both patients with AD and their caregivers. Developing a greater understanding of auditory dysfunction in early AD may shed light on the mechanisms of disease progression and carry diagnostic and therapeutic importance. Read More

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July 2018
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NFE2L2, PPARGC1α, and pesticides and Parkinson's disease risk and progression.

Mech Ageing Dev 2018 Jul 6;173:1-8. Epub 2018 Apr 6.

Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA; Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address:

Objective: To investigate three expression-altering NFE2L2 SNPs and four PPARGC1α previously implicated SNPs and pesticides on Parkinson's disease (PD) risk and symptom progression.

Methods: In 472 PD patients and 532 population-based controls, we examined variants and their interactions with maneb and paraquat (MB/PQ) pesticide exposure on PD onset (logistic regression) and progression of motor symptoms and cognitive decline (n = 192; linear repeated measures).

Results: NFE2L2 rs6721961 T allele was associated with a reduced risk of PD (OR = 0. Read More

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July 2018
2 Reads

Birth weight predicts aging trajectory: A hypothesis.

Mech Ageing Dev 2018 Jul 4;173:61-70. Epub 2018 Apr 4.

Institute of Gerontology NAMS of Ukraine, Vyshgorodskaya st. 67, Kiev 04114, Ukraine. Electronic address:

Increasing evidence suggests that risk for age-related disease and longevity can be programmed early in life. In human populations, convincing evidence has been accumulated indicating that intrauterine growth restriction (IUGR) resulting in low birth weight (<2.5 kg) followed by postnatal catch-up growth is associated with various aspects of metabolic syndrome, type 2 diabetes and cardiovascular disease in adulthood. Read More

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July 2018
3 Reads

The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature.

Authors:
Maria De Luca

Mech Ageing Dev 2018 Apr 4. Epub 2018 Apr 4.

Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 451-1720 2nd Ave S, Birmingham, AL, 35294-3360, USA. Electronic address:

The extracellular matrix (ECM) is an intricate network that provides structural and anchoring support to cells in order to stabilize cell morphology and tissue architecture. The ECM also controls many aspects of the cell's dynamic behavior and fate through its ongoing, bidirectional interaction with cells. These interactions between the cell and components of the surrounding ECM are implicated in several biological processes, including development and adult tissue repair in response to injury, throughout the lifespan of multiple species. Read More

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April 2018
2 Reads

Effect of heterochromatin stability on intestinal stem cell aging in Drosophila.

Mech Ageing Dev 2018 Jul 3;173:50-60. Epub 2018 Apr 3.

Department of Molecular Biology, Pusan National University, Busan, 46241, Republic of Korea. Electronic address:

Chromatin change is one of the crucial causes of aging. Specifically, maintenance of heterochromatin stability is critical for cellular integrity, and its loss induces genomic instability and cellular aging. However, the causes and effects of heterochromatin instability in multicellular tissue aging still remain unclear. Read More

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July 2018
6 Reads

Multivessel analysis of progressive vascular aging in the rat: Asynchronous vulnerability among vascular territories.

Mech Ageing Dev 2018 Jul 29;173:39-49. Epub 2018 Mar 29.

Fundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain; Servicio de Geriatría, Hospital Universitario de Getafe, Getafe, Spain. Electronic address:

Aging induces vascular dysfunction, representing the major risk factor for cardiovascular disease. Our aim was to ascertain specific vulnerability of vascular territories to aging by evaluating the progressive impact of aging on vascular function in four different vascular beds: aorta, mesenteric artery (MA), coronary artery (CA), and penile corpus cavernosum (CC) from 3, 6, 9, 12, 20 or 24 months-old male rats. Contractile/relaxant responses were evaluated in organ chambers (A/CC) and wire myographs (MA/CA). Read More

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July 2018
5 Reads

The impact of oxidative DNA damage and stress on telomere homeostasis.

Mech Ageing Dev 2018 Mar 28. Epub 2018 Mar 28.

Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, UPMC Hillman Cancer Center, 5117 Centre Avenue, University of Pittsburgh, Pittsburgh, PA, 15213, United States. Electronic address:

Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication, they impose a functional limit on the number of times a cell can divide. Critically short telomeres trigger cellular senescence in normal cells, or genomic instability in pre-malignant cells, which contribute to numerous degenerative and aging-related diseases including cancer. Read More

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March 2018
6 Reads

Beyond ROS clearance: Peroxiredoxins in stress signaling and aging.

Ageing Res Rev 2018 Jul 23;44:33-48. Epub 2018 Mar 23.

Department of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium. Electronic address:

Antioxidants were long predicted to have lifespan-promoting effects, but in general this prediction has not been well supported. While some antioxidants do seem to have a clear effect on longevity, this may not be primarily as a result of their role in the removal of reactive oxygen species, but rather mediated by other mechanisms such as the modulation of intracellular signaling. In this review we discuss peroxiredoxins, a class of proteinaceous antioxidants with redox signaling and chaperone functions, and their involvement in regulating longevity and stress resistance. Read More

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July 2018
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Sirtuins in mitochondrial stress: Indispensable helpers behind the scenes.

Ageing Res Rev 2018 Jul 23;44:22-32. Epub 2018 Mar 23.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Mitochondria play an essential part in guaranteeing normal cellular physiological functions through providing ATP and participating in diverse processes and signaling pathways. Recently, more and more studies have revealed the vital roles of mitochondria in coping with stressors in the aging process, metabolic disturbances and neurological disorders. Mitochondrial stress responses, including the mitochondrial unfolded protein response (UPR), antioxidant defense, mitochondrial fission, mitochondrial fusion and mitophagy, are induced to maintain cellular integrity in response to stress. Read More

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July 2018
1 Read

PGC-1α sparks the fire of neuroprotection against neurodegenerative disorders.

Ageing Res Rev 2018 Jul 23;44:8-21. Epub 2018 Mar 23.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China. Electronic address:

Recently, growing evidence has demonstrated that peroxisome proliferator activated receptor γ (PPARγ) coactivator-1α (PGC-1α) is a superior transcriptional regulator that acts via controlling the expression of anti-oxidant enzymes and uncoupling proteins and inducing mitochondrial biogenesis, which plays a beneficial part in the central nervous system (CNS). Given the significance of PGC-1α, we summarize the current literature on the molecular mechanisms and roles of PGC-1α in the CNS. Thus, in this review, we first briefly introduce the basic characteristics regarding PGC-1α. Read More

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July 2018
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4.94 Impact Factor

Protein aggregates and proteostasis in aging: Amylin and β-cell function.

Mech Ageing Dev 2018 Mar 23. Epub 2018 Mar 23.

Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany; German Center for Diabetes Research (DZD), 85764 Muenchen-Neuherberg, Germany. Electronic address:

The ubiquitin-proteasomal-system (UPS) and the autophagy-lysosomal-system (ALS) are both highly susceptible for disturbances leading to the accumulation of cellular damage. A decline of protein degradation during aging results in the formation of oxidatively damaged and aggregated proteins finally resulting in failure of cellular functionality. Besides protein aggregation in response to oxidative damage, amyloids are a different type of protein aggregates able to distract proteostasis and interfere with cellular functionality. Read More

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March 2018
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PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage.

Mech Ageing Dev 2018 Jul 23;173:29-38. Epub 2018 Mar 23.

Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00, Brno, Czech Republic; Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Kamenice 5, Building A29, 625 00, Brno, Czech Republic. Electronic address:

Transposable elements (TEs) are powerful drivers of genome evolutionary dynamics but are principally deleterious to the host organism by compromising the integrity and function of the genome. The transposition of TEs may result in mutations and DNA damage. DNA double-strand breaks (DSBs), which may be caused by the transposition, are one of the processes directly linked to aging. Read More

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July 2018
5 Reads

SOX2 expression diminishes with ageing in several tissues in mice and humans.

Mech Ageing Dev 2018 Mar 21. Epub 2018 Mar 21.

Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; CIBERfes, Madrid, Spain. Electronic address:

SOX2 (Sex-determining region Y box 2) is a transcription factor expressed in several foetal and adult tissues and its deregulated activity has been linked to chronic diseases associated with ageing. Nevertheless, the level of SOX2 expression in aged individuals at the tissue level has not previously been examined. In this work, we show that SOX2 expression decreases significantly in the brain with ageing, in both humans and rodents. Read More

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March 2018
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Laminin-332 regulates differentiation of human interfollicular epidermal stem cells.

Mech Ageing Dev 2018 Apr 16;171:37-46. Epub 2018 Mar 16.

Department of Applied Cell and Regenerative Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, Japan.

Interfollicular epidermal stem cells (IFE-SCs) have self-renewal and differentiation potentials, and maintain epidermal homeostasis. Stem cells in vivo are regulated by the surrounding environment called niche to function properly, however, IFE-SC niche components are not fully understood. In order to elucidate the mechanisms of keeping epidermal homeostasis and of skin aging, and also to develop new therapeutic technologies for skin diseases, we searched for niche factors that regulate IFE-SCs. Read More

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April 2018
2 Reads

Age-related evolutions of the dermis: Clinical signs, fibroblast and extracellular matrix dynamics.

Mech Ageing Dev 2018 Mar 13. Epub 2018 Mar 13.

Laboratoire de Génomique et Radiobiologie de la Kératinopoïèse, Institut de Biologie François Jacob, CEA/DRF/IRCM, 91000, Evry, France; INSERM U967, Fontenay-aux-Roses, France; Université Paris-Diderot, Paris 7, France; Université Paris-Saclay, Paris 11, France. Electronic address:

Ageing is today a major societal concern that is intrinsically associated with the increase of life expectancy. Outside the context of severe degenerative diseases that affect the elderly populations, normal visible signs of ageing, notably skin sagging and wrinkles, influence the social and individual perception of peoples. Accordingly, there is a strong demand for researches on skin ageing. Read More

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March 2018
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Photoaging and skin cancer: Is the inflammasome the missing link?

Mech Ageing Dev 2018 Jun 12;172:131-137. Epub 2018 Mar 12.

Sorbonne Université, INSERM, UMR_S 933, Assistance Publique Hôpitaux de Paris, Hôpital Trousseau, Département de Génétique médicale, Paris, F-75012, France. Electronic address:

Photoaging and epithelial skin tumorigenesis are complex processes triggered mainly by UV radiation from chronic sun exposure. This leads to DNA damage and reactive oxygen species (ROS) production, which initiate an inflammatory response that alters cell structure and function. Changes in cell homeostasis and ROS production activate intracellular multiprotein platforms called inflammasomes. Read More

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June 2018
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Epigenetic mechanisms in amyotrophic lateral sclerosis: A short review.

Mech Ageing Dev 2018 Mar 12. Epub 2018 Mar 12.

Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Slovenia. Electronic address:

Amyotrophic lateral sclerosis is a rapidly progressing neurodegenerative disease. Decades of research show that the etiology of this disease is affected by genetic, epigenetic and environmental factors rather than limited by a patient's genotype. The interaction between these factors is complex, and research has only begun to unravel this issue. Read More

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March 2018
3 Reads