Mitochondrial depletion in CD4(+) and CD19(+) peripheral lymphocytes in early stage Alzheimer's disease.
- Gökhan Terzioğlu,
- Burcu Örmeci,
- Özlem Türksoy,
- Ceyhun Sayman,
- Nilgün Çınar,
- Gökçen Akar Öztürk,
- Gülderen Yanıkkaya Demirel
Mech Ageing Dev 2017 Sep 18;167:24-29. Epub 2017 Sep 18.
HLA Typing Laboratory, Yeditepe University Hospital, İstanbul, Turkey; Department of Immunology, Faculty of Medicine, Yeditepe University, İstanbul, Turkey.
Alzheimer's disease (AD) may be associated with mitochondrial defects. The aim of the present study was to investigate changes in mitochondrial abundance in peripheral lymphocytes of early and late stage AD patients. We analysed levels of mitochondrial DNA (mtDNA) and mean fluorescence intensity (MFI) of the mitochondria-specific antibody 113-1 in CD4(+), CD8(+), CD19(+) and CD56(+) peripheral lymphocytes of early and late stage AD by quantitative real-time PCR and flow cytometry, respectively. Read More