443,116 results match your criteria Ageing & Society [Journal]


The widespread increase in inter-individual variability of gene expression in the human brain with age.

Aging (Albany NY) 2019 Apr 19. Epub 2019 Apr 19.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.

Aging is broadly defined as a time-dependent progressive decline in the functional and physiological integrity of organisms. Previous studies and evolutionary theories of aging suggest that aging is not a programmed process but reflects dynamic stochastic events. In this study, we test whether transcriptional noise shows an increase with age, which would be expected from stochastic theories. Read More

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http://dx.doi.org/10.18632/aging.101912DOI Listing

Robust, ultra-insulative and transparent polyethylene-based hybrid silica aerogel with a novel non-particulate structure.

J Colloid Interface Sci 2019 Apr 9;548:206-216. Epub 2019 Apr 9.

Microcellular Plastics Manufacturing Laboratory, Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario M5S 3G8, Canada. Electronic address:

Aerogels derived from pre-polymerized vinyl trimethoxy silane (VTMS) precursor with nano-size particles are known to exhibit outstanding mechanical and insulation properties. However, the density reduction has been limited by the poor connectivity. This paper presents an innovative technology to generate a new class of VTMS-based hybrid silica aerogels that possess outstanding non-particulate, reticulated structure and superior properties. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.04.028DOI Listing
April 2019
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Moderate hearing loss is related with social frailty in a community-dwelling older adults: The Korean Frailty and Aging Cohort Study (KFACS).

Arch Gerontol Geriatr 2019 Apr 12;83:126-130. Epub 2019 Apr 12.

Department of Family Medicine, Kyung Hee University Medical Center, kyungheedaero 23, dongdaemun-gu, 02447, Seoul, Republic of Korea; Elderly Frailty Research Center, Department of Family Medicine, Kyung Hee University College of Medicine, kyungheedaero 23, dongdaemun-gu, 02447, Seoul, Republic of Korea. Electronic address:

Objectives: To determine whether hearing loss is associated with social frailty in older adults.

Methods: Cross-sectional analysis of cohort study data. Hearing was measured using of Pure-tone audiometry. Read More

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http://dx.doi.org/10.1016/j.archger.2019.04.004DOI Listing

Association between sarcopenia and diabetes in community dwelling elderly in the Amazon region - Viver Mais Project.

Arch Gerontol Geriatr 2019 Mar 27;83:121-125. Epub 2019 Mar 27.

State University Of Pará, Brazil; Hospital Cynthia Charone, Brazil.

Background: Studies indicate the intrinsic relationship between sarcopenia and diabetes mellitus (DM) pathophysiological mechanisms. Changes in insulin and muscular metabolism are features of diabetic patients and can interact as sarcopenic accelerators. Conversely, sarcopenic patients feature lower glucose tolerance and higher serum insulin levels, predisposing them to DM. Read More

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http://dx.doi.org/10.1016/j.archger.2019.03.020DOI Listing

Dopamine receptor D (DRD) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

Neuroimage Clin 2019 Apr 10;23:101822. Epub 2019 Apr 10.

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.

Objective: We aimed to understand the impact of dopamine receptor D (DRD) polymorphisms on neurodegeneration in patients with dementia. We hypothesized that DRDdampened-variants with reduced functional potency would be associated with greater atrophy in regions with higher receptor density. Given that DRD is concentrated in anterior regions of the limbic and cortical forebrain we anticipated genotype effects in patients with a more rostral pattern of neurodegeneration. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101822DOI Listing

Inhibition of TLR9 attenuates skeletal muscle fibrosis in aged sarcopenic mice via the p53/SIRT1 pathway.

Exp Gerontol 2019 Apr 16. Epub 2019 Apr 16.

The First Affiliated Hospital of Chongqing Medical University, Friendship Road 1, YuZhong District, Chongqing 400016, China. Electronic address:

Sarcopenia is an age-related syndrome characterized by a gradual loss of muscle mass and function, but its pathophysiological mechanism remains unclear. Skeletal muscle extracellular matrix (ECM) remodeling is an important pathological change in sarcopenia, and fibrosis is the most obvious manifestation of this change. We found that the expression of the immunoreceptor Toll-like receptor 9 (TLR9) is significantly increased in skeletal muscle in aged mice and is positively related to muscle fibrosis. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.008DOI Listing

Oxidative stress-induced senescence markedly increases disc cell bioenergetics.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

Cellular senescence is a phenotype characterized by irreversible growth arrest, chronic elevated secretion of proinflammatory cytokines and matrix proteases, a phenomenon known as senescence associated secretory phenotype (SASP). Biomarkers of cellular senescence have been shown to increase with age and degeneration of human disc tissue. Senescent disc cells in culture recapitulate features associated with age-related disc degeneration, including increased secretion of proinflammatory cytokines, matrix proteases, and fragmentation of matrix proteins. Read More

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http://dx.doi.org/10.1016/j.mad.2019.04.006DOI Listing

Frailty biomarkers in humans and rodents: current approaches and future advances.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Department of Pharmacology, The University of New South Wales, Sydney, Australia. Electronic address:

Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are limitations to the current state of the research. Future approaches to the identification of frailty biomarkers should include longitudinal studies, studies using animal models of frailty, studies incorporating novel biomarkers combined into composite panels, and studies investigating sex differences and potential overlap between markers of biological age and frailty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374193003
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http://dx.doi.org/10.1016/j.mad.2019.03.007DOI Listing
April 2019
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AGE-RELATED DEFICIT ACCUMULATION AND THE DISEASES OF AGEING.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.

With ageing, the potency of individual risk factors traditionally associated with common illnesses declines. Instead, it is becoming clear that the impact of a wide range of age-related deficits not traditionally considered as risk factors for these illnesses increases. These age-related deficits chiefly confer risk as a group, not individually. Read More

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http://dx.doi.org/10.1016/j.mad.2019.04.005DOI Listing

Molecular, crystal and physicochemical properties of granular waxy corn starch after repeated freeze-thaw cycles at different freezing temperatures.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. Electronic address:

The study was undertaken to reveal the effects of freeze-thaw cycles at different freeze temperature (-20 °C, -40 °C and -80 °C) and the number of freeze-thaw cycles (3, 6, 12, 18, 24 times) on physicochemical and structural properties of waxy corn starch. The number of pores on the surface of starch granules increased, but there was no significant (P < 0.05) effect on molecular weight, transparency, freeze-thaw stability and the crystal structure of starch after repeated freeze-thaw cycle. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.111DOI Listing

The impact of behavioral interventions on cognitive function in healthy older adults: A systematic review.

Authors:
Briana N Sprague

Ageing Res Rev 2019 Apr 16. Epub 2019 Apr 16.

The Pennsylvania State University, 119 Health and Human Development Building, University Park 16802, US. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2019.04.002DOI Listing

The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan.

Mol Cell 2019 Apr;74(2):225-226

Hubrecht Institute of the Royal Netherlands Academy of Arts and Sciences & University Medical Center Utrecht, Utrecht, the Netherlands; Department of Biomedical Science of Cells and Systems, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

The formation of amyloid fibers is usually associated with aging and neurodegeneration. In this issue of Molecular Cell, Ji et al. (2019) demonstrate that the deubiquitinase Otu coalesces into amyloid-like fibers to enhance its activity and ensure its optimum biological function. Read More

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http://dx.doi.org/10.1016/j.molcel.2019.03.038DOI Listing

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

Cell 2019 Apr;177(3):622-638.e22

Department of Biology, University of Rochester, Rochester, NY 14627, USA. Electronic address:

DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel of 18 rodent species with diverse lifespans, we show that more robust DNA double-strand break (DSB) repair, but not nucleotide excision repair (NER), coevolves with longevity. Evolution of NER, unlike DSB, is shaped primarily by sunlight exposure. Read More

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http://dx.doi.org/10.1016/j.cell.2019.03.043DOI Listing

Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip.

PLoS One 2019 19;14(4):e0207834. Epub 2019 Apr 19.

National Health and Environmental Effects Laboratory, US Environmental Protection Agency, Chapel Hill, NC, United States of America.

DNA methylation age (DNAm age) has become a widely utilized epigenetic biomarker for the aging process. The Horvath method for determining DNAm age is perhaps the most widely utilized and validated DNA methylation age assessment measure. Horvath DNAm age is calculated based on methylation measurements at 353 loci, present on Illumina's 450k and 27k DNA methylation microarrays. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207834PLOS

Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs).

Aging (Albany NY) 2019 Apr 19. Epub 2019 Apr 19.

Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester, M5 4WT, United Kingdom.

Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a "synthetic-metabolic" approach, involving two FDA-approved antibiotics and a dietary vitamin supplement. This approach was designed to induce a "rho-zero-like" phenotype in cancer cells. This strategy effectively results in the synergistic eradication of CSCs, using vanishingly small quantities of two antibiotics. Read More

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http://dx.doi.org/10.18632/aging.101905DOI Listing

Replicative and radiation-induced aging: a comparison of gene expression profiles.

Aging (Albany NY) 2019 Apr 19. Epub 2019 Apr 19.

Inсilico Medicine, Inc., Baltimore, MD 21218, USA.

All living organisms are subject to the aging process and experience the effect of ionizing radiation throughout their life. There have been a number of studies that linked ionizing radiation process to accelerated aging, but comprehensive signalome analysis of both processes was rarely conducted. Here we present a comparative signaling pathway based analysis of the transcriptomes of fibroblasts irradiated with different doses of ionizing radiation, replicatively aged fibroblasts and fibroblasts collected from young, middle age and old patients. Read More

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http://dx.doi.org/10.18632/aging.101921DOI Listing

Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats.

Int J Med Mushrooms 2019 ;21(4):381-392

Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China.

We studied Phellinus lonicerinus to determine the cytotoxic effect and the dual estrogenic activities of methyl-hispolon and their relation to estrogen signals in vivo and in vitro. The Glide scores of methyl-hispolon-estrogen receptor α (ERα) and methyl-hispolon-ERβ docked complexes were -7.29 kcal/mol and -6. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030355DOI Listing
January 2019

Longitudinal Muscle and Myocellular Changes in Community-Dwelling Men Over Two Decades of Successful Aging-The ULSAM Cohort Revisited.

J Gerontol A Biol Sci Med Sci 2019 Apr 19. Epub 2019 Apr 19.

Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.

Participants of the population-based Uppsala longitudinal study of adult men (ULSAM) cohort reaching more than 88 years of age (survivors, S) were investigated at age 70, 82, and 88-90 and compared at 70 years with non-survivors (NS) not reaching 82 years. Body composition, muscle mass and muscle histology were remarkably stable over 18 years of advanced aging in S. Analysis of genes involved in muscle remodeling showed that S had higher mRNA levels of myogenic differentiation factors (Myogenin, MyoD), embryonic myosin (eMyHC), enzymes involved in regulated breakdown of myofibrillar proteins (Smad2, Trim32, MuRF1,) and NCAM compared with healthy adult men (n = 8). Read More

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http://dx.doi.org/10.1093/gerona/glz068DOI Listing

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study.

JAMA Netw Open 2019 Apr 5;2(4):e192745. Epub 2019 Apr 5.

Framingham Heart Study, Framingham, Massachusetts.

Importance: Dementia risk may be attenuated by physical activity (PA); however, the specific activity levels optimal for dementia prevention are unclear. Moreover, most older adults are unable to meet the nationally recommended PA guidelines, set at 150 minutes of moderate to vigorous PA per week.

Objective: To assess the association of total steps walked per day and total dose (intensity × duration) of PA with brain volumes on magnetic resonance imaging (MRI) among Framingham Heart Study participants. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2745DOI Listing

Growth hormone induces colon DNA damage independent of IGF-1.

Endocrinology 2019 Apr 19. Epub 2019 Apr 19.

Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

DNA damage occurs as a result of environmental insults and aging, and if unrepaired, may lead to chromosomal instability and tumorigenesis. As growth hormone (GH) suppresses ATM kinase phosphorylation, decreases DNA repair, and increases DNA damage accumulation, we elucidated whether GH effects on DNA damage are mediated through induced insulin-like growth factor (IGF)-1. In non-tumorous human colon cells, GH, but not IGF-1, enhanced DNA damage. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00132DOI Listing
April 2019
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Tomato fruit ripening factor NOR controls leaf senescence.

J Exp Bot 2019 Apr 19. Epub 2019 Apr 19.

Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg, Potsdam-Golm, Germany.

NAC transcription factors (TFs) are important regulators of expressional reprogramming during plant development, stress responses, and leaf senescence. NAC TFs also play important roles in fruit ripening. In tomato (Solanum lycopersicum), one of the best characterized NACs involved in fruit ripening is NON-RIPENING (NOR), and the non-ripening (nor) mutation has been widely used to extend fruit shelf life in elite varieties. Read More

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https://academic.oup.com/jxb/advance-article/doi/10.1093/jxb
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http://dx.doi.org/10.1093/jxb/erz098DOI Listing
April 2019
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Age-Dependent Increase in Incidence of Staphylococcus aureus Bacteremia, Denmark, 2008-2015.

Emerg Infect Dis 2019 May;25(5)

Staphylococcus aureus bacteremia (SAB) is a major cause of illness and death worldwide. We analyzed temporal trends of SAB incidence and death in Denmark during 2008-2015. SAB incidence increased 48%, from 20. Read More

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http://dx.doi.org/10.3201/eid2505.181733DOI Listing
May 2019
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Lysyl oxidase-like 2 (LOXL2) depletion is protective in age-associated vascular stiffening.

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

ACCM, Johns Hopkins University, United States.

Vascular stiffening and its sequelae are major causes of morbidity and mortality in the elderly. The increasingly accepted concept of "smooth muscle cell (SMC) stiffness syndrome" along with matrix deposition has emerged in vascular biology to account for the mechanical phenotype of arterial aging, but the molecular targets remain elusive. In this study, using an unbiased proteomic analysis, we identified lysyl oxidase-like 2 (LOXL2) as a critical SMC mediator for age-associated vascular stiffening. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00670.2018
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http://dx.doi.org/10.1152/ajpheart.00670.2018DOI Listing
April 2019
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Promising therapies for the treatment of frontotemporal dementia clinical phenotypes: from symptomatic to disease-modifying drugs.

Expert Opin Pharmacother 2019 Apr 19:1-17. Epub 2019 Apr 19.

a Neurodegenerative Disease Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs , University of Bari "Aldo Moro" , Bari , Italy.

Introduction: Frontotemporal dementia (FTD) is a heterogeneous clinical entity that includes several disorders characterized by different cellular mechanisms. Distinctive clinical features in FTD include behavioral, affective, and cognitive symptoms. Unfortunately, little progress has been made over the past 20 years in terms of the development of effective disease-modifying drugs with the currently available symptomatic treatments having limited clinical utility. Read More

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http://dx.doi.org/10.1080/14656566.2019.1598377DOI Listing

Effect of Chaplaincy Visits in an Elder Care Setting: A Pilot Analysis of Existing Data.

J Health Care Chaplain 2019 Apr 19:1-14. Epub 2019 Apr 19.

g Social and Health Policy Research, Alfred A. and Gilda Slifka Chair in Social Gerontological Research, Institute for Aging Research , Hebrew Senior Life , Boston , Massachusetts , USA.

Religion is a consistent, positive predictor of health in older adults. Studies focused on religion and spirituality as a coping mechanism find significant positive effects on the lives of older adults. This study investigated how an older person's living situation influences his or her access to spiritual and religious resources and, consequently, his or her health. Read More

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http://dx.doi.org/10.1080/08854726.2019.1599257DOI Listing

Investigating associations between pain and complicated grief symptoms in bereaved Japanese older adults.

Aging Ment Health 2019 Apr 19:1-7. Epub 2019 Apr 19.

a Brookdale Center for Healthy Aging , Hunter College of the City University of New York , New York , New York , USA.

Objectives: About 10% of those who lose a loved one in hospice or palliative care settings will experience a mental health condition characterized by severe, prolonged grief responses. Criteria for this condition have evolved; we refer to this condition as Complicated Grief (CG) because it is one of the more common names. While there are some indications of associations between CG and poor physical health, explorations of the association between CG and pain is limited. Read More

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http://dx.doi.org/10.1080/13607863.2019.1594166DOI Listing

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.

Autophagy 2019 Apr 19:1-17. Epub 2019 Apr 19.

a Department of Cell Biology and Biophysics, Faculty of Biology , National and Kapodistrian University of Athens , Athens , Greece.

The ubiquitin-proteasome pathway (UPP) is central to proteostasis network (PN) functionality and proteome quality control. Yet, the functional implication of the UPP in tissue homeodynamics at the whole organism level and its potential cross-talk with other proteostatic or mitostatic modules are not well understood. We show here that knock down (KD) of proteasome subunits in Drosophila flies, induced, for most subunits, developmental lethality. Read More

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http://dx.doi.org/10.1080/15548627.2019.1596477DOI Listing

Aging and Orienting of Visual Attention: Emergence of a Rightward Attentional Bias with Aging?

Dev Neuropsychol 2019 Apr 19:1-15. Epub 2019 Apr 19.

b Axe "Neuropsychologie, Audition, Cognition, Action" (NACA), Laboratoire "Psychologie : Interactions, Temps, Emotions, Cognition" (PSITEC), EA 4072 , Université de Lille , Villeneuve d'Ascq , France.

Although some studies described the apparition of a rightward bias of attention with aging, no study has examined if this bias could be explained by modifications based on age in the mechanisms of attention orienting and, specially, in the cueing effects. 48 participants of different ages were tested with a spatial cueing paradigm to assess mechanisms of attention orienting. Our results suggest the appearance of specific difficulties to orient and reorient attention towards the left side of space with aging. Read More

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https://www.tandfonline.com/doi/full/10.1080/87565641.2019.1
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http://dx.doi.org/10.1080/87565641.2019.1605517DOI Listing
April 2019
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Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations.

Aust N Z J Psychiatry 2019 Apr 19:4867419844325. Epub 2019 Apr 19.

2 Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Clayton, VIC, Australia.

Objective: Young adulthood is a crucial neurodevelopmental period during which impulsive and compulsive problem behaviours commonly emerge. While traditionally considered diametrically opposed, impulsive and compulsive symptoms tend to co-occur. The objectives of this study were as follows: (a) to identify the optimal trans-diagnostic structural framework for measuring impulsive and compulsive problem behaviours, and (b) to use this optimal framework to identify common/distinct antecedents of these latent phenotypes. Read More

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http://dx.doi.org/10.1177/0004867419844325DOI Listing

Hepcidin is not essential for mediating testosterone's effects on erythropoiesis.

Andrology 2019 Apr 19. Epub 2019 Apr 19.

Research Program in Men's Health: Aging and Metabolism, The Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

Background: We have shown that testosterone administration suppresses hepcidin, stimulates iron-dependent erythropoiesis, and increases hemoglobin and hematocrit.

Objective: We investigated whether testosterone-mediated suppression of hepcidin plays an essential role in mediating testosterone's stimulatory effects on erythropoiesis.

Methods: We utilized two mouse models to elucidate the role of hepcidin as a mediator of testosterone's effects on erythropoiesis: First, we used a whole-body hepcidin knockout (HepKO) mouse. Read More

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http://dx.doi.org/10.1111/andr.12622DOI Listing

Particulate Matter Induces Proinflammatory Cytokines via Phosphorylation of p38 MAPK Possibly Leading to Dermal Inflammaging.

Exp Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

Particulate matter (PM) is known to have harmful effects on human health. Epidemiological studies have suggested that PM exposure is related to skin diseases and extrinsic skin aging. However, the mechanisms by which PM affects skin are unclear. Read More

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http://dx.doi.org/10.1111/exd.13943DOI Listing

Reliability and Validity of SymTrak, a Multi-Domain Tool for Monitoring Symptoms of Older Adults with Multiple Chronic Conditions.

J Gen Intern Med 2019 Apr 18. Epub 2019 Apr 18.

School of Medicine, Indiana University, Indianapolis, IN, USA.

Background: A reliable and valid clinically practical multi-domain self-report and caregiver-report tool is needed for tracking actionable symptoms in primary care for elderly patients with multiple chronic conditions (MCCs).

Objective: Assess internal consistency reliability, test-retest reliability, construct validity, and sensitivity to change for SymTrak.

Design And Participants: Among 600 (200 patient-caregiver dyads, 200 patients without an identified caregiver) participants, SymTrak was telephone interviewer-administered at baseline and 3-month follow-up, and at 24 h post-baseline for assessing test-retest reliability in a random subsample of 180 (60 dyads, 60 individual patients) participants. Read More

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http://dx.doi.org/10.1007/s11606-018-4780-4DOI Listing

The capability of L-carnitine-mediated antioxidant on cock during aging: evidence for the improved semen quality and enhanced testicular expressions of GnRH1, GnRHR, and melatonin receptors MT 1/2.

Poult Sci 2019 Apr 18. Epub 2019 Apr 18.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education and Department of Basic Veterinary Medicine, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.

Precise natural anti-oxidative compounds have facilitated the research of infertile gametes and the development of novel bio-therapeutics, especially the molecules that are based on the reduction of oxidative stress, such as L-carnitine (LC). In addition to, the defect in the functioning of sperm mitochondrial and the decreasing seminal antioxidant ability due to aging, its essential role in permitting the mitochondrial import and oxidation of long chain fatty acids is worthy. Therefore, current study was designed to investigate the effects of dietary LC on semen quality, seminal antioxidant activity, and their implications for the fertility in aged cocks for 12 wk. Read More

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http://dx.doi.org/10.3382/ps/pez201DOI Listing
April 2019
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A systematic review and meta-analysis of environmental, lifestyle and health factors associated with DNA methylation age.

J Gerontol A Biol Sci Med Sci 2019 Apr 17. Epub 2019 Apr 17.

School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Victoria, Australia.

DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an individual's chronological age, and can predict of their risk of age-related disease and mortality. This study reviewed the evidence that environmental, lifestyle and health factors are associated with the Horvath and Hannum epigenetic clocks. A systematic search identified 61 studies. Read More

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https://academic.oup.com/biomedgerontology/advance-article/d
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http://dx.doi.org/10.1093/gerona/glz099DOI Listing
April 2019
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Inconvenient Truths About Human Longevity.

J Gerontol A Biol Sci Med Sci 2019 Apr 17. Epub 2019 Apr 17.

University of Oklahoma.

The rise in human longevity is one of humanity's crowning achievements. While advances in public health beginning in the 19th century initiated the rise in life expectancy, recent gains have been achieved by reducing death rates at middle and older ages. A debate about the future course of life expectancy has been ongoing for the last quarter century. Read More

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http://dx.doi.org/10.1093/gerona/glz098DOI Listing
April 2019
2 Reads

Social Participation in the Daily Lives of Frail Older Adults: Types of Participation and Influencing Factors.

J Gerontol B Psychol Sci Soc Sci 2019 Apr 17. Epub 2019 Apr 17.

Vrije Universiteit Brussel, Brussels, Belgium.

Objectives: The advantages of social participation for older adults are well-established and have been adopted in aging policy frameworks. However, little is known about the social participation of frail older adults. This research examined the types of social interaction of very frail older adults and the factors influencing this participation. Read More

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https://academic.oup.com/psychsocgerontology/advance-article
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http://dx.doi.org/10.1093/geronb/gbz045DOI Listing
April 2019
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A Computational Model of the Escape Response Latency in the Giant Fiber System of .

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 15.

Institute of Healthy Ageing, and GEE, University College London, London WC1E 6BT, United Kingdom.

The giant fiber system (GFS) is a multi-component neuronal pathway mediating rapid escape response in the adult fruit-fly , usually in the face of a threatening visual stimulus. Two branches of the circuit promote the response by stimulating an escape jump followed by flight initiation. A recent work demonstrated an age-associated decline in the speed of signal propagation through the circuit, measured as the stimulus-to-muscle depolarization response latency. Read More

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http://dx.doi.org/10.1523/ENEURO.0423-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469880PMC

Generation and Characterization of Germline-Specific Autophagy and Mitochondrial Reactive Oxygen Species Reporters in .

Front Cell Dev Biol 2019 3;7:47. Epub 2019 Apr 3.

Developmental Biology Group, Agharkar Research Institute, Pune, India.

Oogenesis is a fundamental process that forms the egg and, is crucial for the transmission of genetic information to the next generation. oogenesis has been used extensively as a genetically tractable model to study organogenesis, niche-germline stem cell communication, and more recently reproductive aging including germline stem cell (GSC) aging. Autophagy, a lysosome-mediated degradation process, is implicated in gametogenesis and aging. Read More

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http://dx.doi.org/10.3389/fcell.2019.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456670PMC

The Swallowing Clinical Assessment Score in Parkinson's Disease (SCAS-PD) Is a Valid and Low-Cost Tool for Evaluation of Dysphagia: A Gold-Standard Comparison Study.

J Aging Res 2019 13;2019:7984635. Epub 2019 Mar 13.

Graduate Program in Biomedical Gerontology, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Background: Dysphagia is a predictor of mortality in Parkinson's disease (PD). Developing alternative methods to videofluoroscopy swallowing study (VFSS) for the evaluation of dysphagia is a public health necessity. The is an alternative and low-cost tool for diagnosis of dysphagia, but had not been properly validated in comparison to the gold-standard method. Read More

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http://dx.doi.org/10.1155/2019/7984635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436359PMC
March 2019
1 Read

The Link Between Epigenetic Clocks for Aging and Senescence.

Authors:
Wolfgang Wagner

Front Genet 2019 3;10:303. Epub 2019 Apr 3.

Division of Stem Cell Biology and Cellular Engineering, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany.

Replicative senescence of cells is often considered as counterpart for aging of the organism . In fact, both processes are associated with functional decay and similar molecular modifications. On epigenetic level, replicative senescence and aging evoke characteristic modifications in the DNA methylation (DNAm) pattern, but at different sites in the genome. Read More

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http://dx.doi.org/10.3389/fgene.2019.00303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456648PMC
April 2019
2 Reads

Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools.

Front Genet 2019 3;10:239. Epub 2019 Apr 3.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.

Background: Imputation has become a standard approach in genome-wide association studies (GWAS) to infer untyped markers. Although feasibility for common variants imputation is well established, we aimed to assess rare and ultra-rare variants' imputation in an admixed Caribbean Hispanic population (CH).

Methods: We evaluated imputation accuracy in CH ( = 1,000), focusing on rare (0. Read More

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http://dx.doi.org/10.3389/fgene.2019.00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456789PMC

Traumatic Injury and Exposure to Mitochondrial-Derived Damage Associated Molecular Patterns Suppresses Neutrophil Extracellular Trap Formation.

Front Immunol 2019 2;10:685. Epub 2019 Apr 2.

Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.

Major traumatic injury induces significant remodeling of the circulating neutrophil pool and loss of bactericidal function. Although a well-described phenomenon, research to date has only analyzed blood samples acquired post-hospital admission, and the mechanisms that initiate compromised neutrophil function post-injury are therefore poorly understood. Here, we analyzed pre-hospital blood samples acquired from 62 adult trauma patients (mean age 44 years, range 19-95 years) within 1 h of injury (mean time to sample 39 min, range 13-59 min). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455291PMC

Aging and Comorbidities in Acute Pancreatitis II.: A Cohort-Analysis of 1203 Prospectively Collected Cases.

Front Physiol 2018 2;9:1776. Epub 2019 Apr 2.

Institute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.

Our meta-analysis indicated that aging influences the outcomes of acute pancreatitis (AP), however, a potential role for comorbidities was implicated, as well. Here, we aimed to determine how age and comorbidities modify the outcomes in AP in a cohort-analysis of Hungarian AP cases. Data of patients diagnosed with AP by the revised Atlanta criteria were extracted from the Hungarian Registry for Pancreatic Patients. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01776
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http://dx.doi.org/10.3389/fphys.2018.01776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454835PMC
April 2019
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Aging and Comorbidities in Acute Pancreatitis I: A Meta-Analysis and Systematic Review Based on 194,702 Patients.

Front Physiol 2019 2;10:328. Epub 2019 Apr 2.

Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.

Acute pancreatitis (AP) is one of the most common cause of hospitalization among gastrointestinal diseases worldwide. Although most of the cases are mild, approximately 10-20% of patients develop a severe course of disease with higher mortality rate. Scoring systems consider age as a risk factor of mortality and severity (BISAP; >60 years, JPN>70 years, RANSON; >55 years, APACHE II >45 years). Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00328
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http://dx.doi.org/10.3389/fphys.2019.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454469PMC
April 2019
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4--Carboxymethylascochlorin Inhibits Expression Levels of on Inflammation-Related Cytokines and Matrix Metalloproteinase-9 Through NF-κB/MAPK/TLR4 Signaling Pathway in LPS-Activated RAW264.7 Cells.

Front Pharmacol 2019 27;10:304. Epub 2019 Mar 27.

Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea.

Toll-like receptor 4 (TLR4) and matrix metalloproteinase-9 (MMP-9) are known to play important roles in inflammatory diseases such as arteriosclerosis and plaque instability. The purpose of this study was to perform the effect of 4--carboxymethylascochlorin (AS-6) on MMP-9 expression in lipopolysaccharide (LPS)-induced murine macrophages and signaling pathway involved in its anti-inflammatory effect. Effect of AS-6 on MAPK/NF-κB/TLR4 signaling pathway in LPS-activated murine macrophages was examined using ELISA, Western blotting, reverse transcription polymerase chain reaction (RT-PCR) and fluorescence immunoassay. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2019.00304
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http://dx.doi.org/10.3389/fphar.2019.00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445864PMC
March 2019
1 Read

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer's Disease.

Front Aging Neurosci 2019 2;11:74. Epub 2019 Apr 2.

Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, United States.

Several models have been proposed for the evolution of Alzheimer's disease (AD) biomarkers. The aim of this study was to identify changepoints in a range of biomarkers during the preclinical phase of AD. We examined nine measures based on cerebrospinal fluid (CSF), magnetic resonance imaging (MRI) and cognitive testing, obtained from 306 cognitively normal individuals, a subset of whom subsequently progressed to the symptomatic phase of AD. Read More

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http://dx.doi.org/10.3389/fnagi.2019.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454004PMC

Plasma Vitamin C Concentrations and Cognitive Function: A Cross-Sectional Study.

Front Aging Neurosci 2019 2;11:72. Epub 2019 Apr 2.

Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, VIC, Australia.

Vitamin-C is a water soluble molecule that humans have lost the ability to produce. Vitamin-C plays a role in CNS functions such as neuronal differentiation, maturation, myelin formation and modulation of the catecholaminergic systems. A recent systematic review by our team indicated the need for further research into the relationship between plasma vitamin C and cognition in cognitively intact participants using plasma vitamin C concentrations instead of estimates derived from food-frequency-questionnaires (FFQ), and more sensitive cognitive assessments suitable for cognitive abilities vulnerable to aging. Read More

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00072
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http://dx.doi.org/10.3389/fnagi.2019.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454201PMC
April 2019
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Age, but Not Amyloidosis, Induced Changes in Global Levels of Histone Modifications in Susceptible and Disease-Resistant Neurons in Alzheimer's Disease Model Mice.

Front Aging Neurosci 2019 3;11:68. Epub 2019 Apr 3.

Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.

There is increasing interest in the role of epigenetic alterations in Alzheimer's disease (AD). The epigenome of every cell type is distinct, yet data regarding epigenetic change in specific cell types in aging and AD is limited. We investigated histone tail modifications in neuronal subtypes in wild-type and APP/PS1 mice at 3 (pre-pathology), 6 (pathology-onset) and 12 (pathology-rich) months of age. Read More

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http://dx.doi.org/10.3389/fnagi.2019.00068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456813PMC
April 2019
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5XFAD Mice Show Early Onset Gap Detection Deficits.

Front Aging Neurosci 2019 2;11:66. Epub 2019 Apr 2.

Department of Psychology, Institute of Neuroscience, University of Oregon, Eugene, OR, United States.

Alzheimer's patients show auditory temporal processing deficits very early in disease progression, before the onset of major cognitive impairments. In addition to potentially contributing to speech perception and communication deficits in patients, this also represents a potential early biomarker for Alzheimer's. For this reason, tests of temporal processing such as gap detection have been proposed as an early diagnosis tool. Read More

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00066
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http://dx.doi.org/10.3389/fnagi.2019.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454034PMC
April 2019
1 Read

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice.

Front Cell Neurosci 2019 2;13:133. Epub 2019 Apr 2.

Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.

The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can be expressed and secreted. Read More

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http://dx.doi.org/10.3389/fncel.2019.00133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454015PMC