438,058 results match your criteria Ageing & Society [Journal]


The self-perceptions of aging were an important factor associated with the quality of life in Chinese elderly with hypertension.

Psychogeriatrics 2019 Feb 20. Epub 2019 Feb 20.

Division of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: In China, quality of life (QOL) of the elderly with hypertension was lower than that of normal elderly and lower self-perceptions of aging (SPA) in the elderly with chronic diseases have been shown. Previous studies showed that SPA played a key role in QOL of the elderly. We hypothesised that SPA were associated with QOL in Chinese elderly with hypertension, with more negative SPA predicting lower QOL. Read More

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http://dx.doi.org/10.1111/psyg.12400DOI Listing
February 2019

Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):685-693

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.

Purpose: To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects.

Methods: Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RTP and VVD were measured at the macula. Read More

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http://dx.doi.org/10.1167/iovs.18-25864DOI Listing
February 2019

The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality.

Aging (Albany NY) 2019 Feb 20. Epub 2019 Feb 20.

State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, Jiangsu, P.R. China.

Tight control of energy metabolism is essential for normal cell function and organism survival. PKM (pyruvate kinase, muscle) isoforms 1 and 2 originate from alternative splicing of PKM pre-mRNA. They are key enzymes in oxidative phosphorylation and aerobic glycolysis, respectively, and are essential for ATP generation. Read More

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http://dx.doi.org/10.18632/aging.101802DOI Listing
February 2019

Don't Ruin My Life - Aging and Driving in the 21st Century.

Authors:
Louise Aronson

N Engl J Med 2019 Feb;380(8):705-707

From the Division of Geriatrics, Department of Medicine, University of California, San Francisco, San Francisco.

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http://dx.doi.org/10.1056/NEJMp1613342DOI Listing
February 2019

Effect of UV aging on translucency of currently used esthetic CAD-CAM materials.

J Esthet Restor Dent 2019 Feb 20. Epub 2019 Feb 20.

Faculty of Dentistry, Prosthodontics Department, İzmir Katip Çelebi University, Turkey.

Objectives: To evaluate the relative translucency parameter (RTP) values of computer-aided design (CAD)-computer-aided manufacturing (CAM) materials after UV aging.

Materials And Methods: 70 specimens (n = 10) of Bruxzir Anterior (BA); E.max Cad (EC); Lava Ultimate (LU); Cerasmart (CE); Vita Enamic (VE); Vita Suprinity (VS); Vita Mark II (VM) were prepared (1 mm ± 0. Read More

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http://dx.doi.org/10.1111/jerd.12460DOI Listing
February 2019

Nursing people with intellectual disability and dementia experiencing pain: An integrative review.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Nursing and Midwifery, University of Limerick, Ireland.

Aim: To explore the current evidence of nurses caring for people with Intellectual Disability and dementia who experience pain.

Background: People with intellectual disability are ageing and are experiencing age related health conditions including dementia and conditions associated with pain, but at an earlier age. Addressing the needs of people with intellectual disability who develop dementia is a new challenge for nurses. Read More

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http://dx.doi.org/10.1111/jocn.14834DOI Listing
February 2019

Caring for aged people: The influence of personal resilience and workplace climate on 'doing good' and 'feeling good'.

J Adv Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Management, Monash University, Melbourne, Victoria, Australia.

Aims: This study examines the impact of personal resilience on the well-being of care workers and how perceptions of the quality of care provided and the social climate in the organization influences this relationship. We examine quality of patient care as both a mediating and outcome variable to better understand if 'doing good' (quality of care) leads to 'feeling good' (personal well-being).

Background: As an ageing population and the care for the older people has become an increasing challenge to many societies, developing and retaining a professional care workforce through effective management is vital in providing care services. Read More

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http://dx.doi.org/10.1111/jan.13935DOI Listing
February 2019

Epigenetic age acceleration in adolescence associates with BMI, inflammation and risk score for middle age cardiovascular disease.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Curtin/UWA Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, The University of Western Australia.

Background: 'Accelerated ageing', assessed by adult DNA methylation predicts cardiovascular disease (CVD). Adolescent accelerated aging might predict CVD earlier. We investigated whether epigenetic age acceleration (assessed age 17-years) associated with adiposity/CVD-risk measured (ages 17, 20, 22-years), and projected CVD by middle-age. Read More

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http://dx.doi.org/10.1210/jc.2018-02076DOI Listing
February 2019

T and B cell subsets differentially correlate with amyloid deposition and neurocognitive function in patients with amnestic mild cognitive impairment after one year of physical activity.

Exerc Immunol Rev 2019 ;25:34-49

Dept. of Neurology & Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, 75390, USA. Dept. of Neurology, University of Kentucky, 741 S. Limestone St, Lexington, KY, 40506, USA.

Individuals with amnestic mild cognitive impairment (aMCI) experience cognitive declines in learning and memory greater than expected for normal aging, and are at a high risk of dementia. We previously reported that sedentary aMCI patients exhibited neuroinflammation that correlated with brain amyloid beta (Aβ) burden, as determined by 18F-florbetapir positron emission tomography (PET). These aMCI patients enrolled in a one-year randomized control trial (AETMCI, NCT01146717) to test the beneficial effects of 12 months of moderate-to-high intensity aerobic exercise training (AET) or stretching/toning (ST) control intervention on neurocognitive function. Read More

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January 2019

Short Telomere Subtelomeric Hypomethylation is associated with Telomere Attrition in Elderly Diabetic Patients.

Can J Physiol Pharmacol 2019 Feb 20. Epub 2019 Feb 20.

Abe Internal Mesical Clinic, Internal Medicine, Oita, Japan ;

Telomere shortening is well known to be associated with the aging process and aging-associated diseases, including diabetes. The telomere length and subtelomeric methylation status in peripheral leucocytes (LTL) were compared in elderly type 2 diabetes patients (T2D) and diabetes free controls (C). The methylation status was analyzed the between of MspI-TRF lengths and HpaII-TRF lengths by using methylation-sensitive and -insensitive restriction enzyme isoschizomers, MspI and HpaII, respectively. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0568DOI Listing
February 2019

Comparative Effectiveness of Adjunctive Psychotropic Medications in Patients With Schizophrenia.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York.

Importance: People with schizophrenia are commonly treated with psychotropic medications in addition to antipsychotics, but there is little evidence about the comparative effectiveness of these adjunctive treatment strategies.

Objective: To study the comparative real-world effectiveness of adjunctive psychotropic treatments for patients with schizophrenia.

Design, Setting, And Participants: This comparative effectiveness study used US national Medicaid data from January 1, 2001, to December 31, 2010, to examine the outcomes of initiating treatment with an antidepressant, a benzodiazepine, a mood stabilizer, or another antipsychotic among adult outpatients (aged 18-64 years) diagnosed with schizophrenia who were stably treated with a single antipsychotic. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4489DOI Listing
February 2019

Cellular Senescence in the Lung Across the Age Spectrum.

Am J Physiol Lung Cell Mol Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, United States.

Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines, growth factors and remodeling proteins (senescence associated secretory phenotype; SASP) that have autocrine and paracrine effects on the tissue microenvironment. SASP can promote remodeling, inflammation, infectious susceptibility, angiogenesis and proliferation, while hindering tissue repair and regeneration. While the role of senescence and contributions of senescent cells are increasingly recognized in the context of aging and a variety of disease states, relatively less is known regarding the portfolio and influences of senescent cells in normal lung growth and aging per se, or in the induction or progression of lung diseases across the age spectrum such as bronchopulmonary dysplasia, asthma, COPD, or pulmonary fibrosis. Read More

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http://dx.doi.org/10.1152/ajplung.00424.2018DOI Listing
February 2019

Micro-RNA335-5p targeted inhibition of sKlotho and promoted oxidative stress-mediated aging of endothelial cells.

Biomark Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Geriatrics/West China hospital of SCU, Chengdu, China.

Aim: MiR-335-5p expression might induce endothelial cells (ECs) aging and target inhibit sKlotho. This study aimed to investigate whether oxidative stress evoked miR-335-5p expression and whether miR-335-5p-regulated ECs function through sKlotho.

Methods: The expression of miR-335-5p was detected in human umbilical vein endothelial cells treated with HO. Read More

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http://dx.doi.org/10.2217/bmm-2018-0430DOI Listing
February 2019

The pharmacologic management of multiple myeloma in older adults.

Expert Opin Pharmacother 2019 Feb 20:1-16. Epub 2019 Feb 20.

d Department of Medicine, Division of Hematology and Oncology , Case Western Reserve University , Cleveland , OH , USA.

Introduction: Multiple myeloma is a disease predominately affecting older adults. Pivotal to treating older adults is understanding their physiologic differences compared to younger subjects and how the complexity of therapies has an impact upon this patient population. Areas covered: Herein, the authors address the efficacy of chemotherapy regimens, decision-making for older adults, chemotherapy-associated toxicity and the approach to management. Read More

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http://dx.doi.org/10.1080/14656566.2019.1577822DOI Listing
February 2019

Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers.

Psychiatry Res Neuroimaging 2019 Feb 10;285:58-63. Epub 2019 Feb 10.

Department of Psychology & Neuroscience, University of Colorado Boulder, 345 UCB, Boulder, CO, United States.

Exploring associations among cannabis use, brain structure, and cognitive function in older adults offers an opportunity to observe potential harm or benefit of cannabis. This pilot study assessed structural magnetic resonance imaging in older adults who were either current cannabis users (n = 28; mean age 69.8 years, 36% female) or nonusers (n = 28; mean age 66. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.02.001DOI Listing
February 2019

Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.

Biomed Pharmacother 2019 Feb 19;112:108669. Epub 2019 Feb 19.

Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China; Department of Respiratory Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China. Electronic address:

Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease with a poor prognosis and limited treatment options. The incidence of IPF increases with age, and the mechanisms related to aging such as cellular senescence have been strongly implicated in disease pathology. Therefore, a better understanding of fibroblasts senescence might provide a new therapeutic strategy to prevent and treat pulmonary fibrosis. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108669DOI Listing
February 2019

The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women.

Psychoneuroendocrinology 2019 Feb 6;104:18-24. Epub 2019 Feb 6.

Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Epidemiology, Yale School of Public Health, New Haven, CT 06511, USA. Electronic address:

Background: Higher mortality experienced by socially disadvantaged groups and/or racial/ethnic minorities is hypothesized to be, at least in part, due to an acceleration of the aging process. Using a new epigenetic aging measure, Levine DNAmAge, this study aimed to investigate whether epigenetic aging accounts for mortality disparities by race/ethnicity and education in a sample of U.S. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.01.028DOI Listing
February 2019

Episodic reconstruction contributes to high-confidence false recognition memories in older adults: Evidence from event-related potentials.

Brain Cogn 2019 Feb 18;132:13-21. Epub 2019 Feb 18.

Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Electronic address:

Older adults demonstrate greater susceptibility to high-confidence memory distortions. Cognitive processes underlying memory errors in older adults remain unclear. Here, in a categorized pictures paradigm, we used the event-related potential (ERP) to examine the electrophysiological correlates of false recognition. Read More

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http://dx.doi.org/10.1016/j.bandc.2019.02.002DOI Listing
February 2019

Student nurses' career motivation toward gerontological nursing: A longitudinal study.

Nurse Educ Today 2019 Feb 6;76:165-171. Epub 2019 Feb 6.

School of Nursing, Shandong University, Jinan, Shandong, China. Electronic address:

Background: The intensity of student nurses' motivation toward a certain career can influence their behaviors for career choice and decision making. However, little is known about the career motivation among student nurses toward gerontological nursing and their influencing factors.

Objectives: The objectives of this study were to examine student nurses' career motivation toward gerontological nursing and to explore potential predictors using Bandura's reciprocal determinism. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.01.028DOI Listing
February 2019

Organic molecular markers in marine aerosols over the Western Mediterranean Sea.

Environ Pollut 2019 Feb 10;248:145-158. Epub 2019 Feb 10.

National Research Council of Italy, Institute of Atmospheric Pollution Research (CNR-IIA), Via Salaria km 29.3 - P.O. Box 10, I-00015, Monterotondo RM, Italy.

A scientific campaign was undertaken along the Western sector of the Mediterranean Sea in the summer 2015 (26th Jun to 13th Jul), with the goal of gathering information about organic contaminants affecting marine aerosol over the Italian seas and with a special focus on changes in composition due to sources. 24 PM atmospheric samples in total were chemically characterized, including polycyclic aromatic hydrocarbons (PAHs), aliphatic hydrocarbons (n-alkanes) and phthalate esters. Contemporarily, regulated gaseous toxicants (i. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.020DOI Listing
February 2019

Is there a specific memory signature associated with Aβ-PET positivity in patients with amnestic mild cognitive impairment?

Neurobiol Aging 2019 Jan 31;77:94-103. Epub 2019 Jan 31.

Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

Amnestic mild cognitive impairment (aMCI) is a clinical entity with various potential etiologies including but not limited to Alzheimer's disease. We examined whether a positive ([18F]Florbetapir) beta amyloid positron emission tomography scan, supporting underlying Alzheimer's disease pathophysiology, was associated with specific memory deficits in 48 patients with aMCI (33 beta amyloid positive, 15 beta amyloid negative). Memory was evaluated using an autobiographical fluency task and a word-list learning task with 2 different encoding types (shallow/incidental versus deep/intentional). Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.017DOI Listing
January 2019

Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons.

Neurobiol Aging 2019 Jan 30;77:87-93. Epub 2019 Jan 30.

Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. Electronic address:

The convergence between amyloid precursor protein (APP) and its β-secretase β-site APP cleaving enzyme 1 (BACE1) is a prerequisite for the generation of β-amyloid peptide, a key pathogenic agent for Alzheimer's disease. Yet the underlying molecular mechanisms regulating their convergence remain unclear. Here, we show that the polarity protein partitioning-defective 3 (Par3) regulates the polarized convergence between APP and BACE1 in hippocampal neurons. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.023DOI Listing
January 2019

Prenatal noise stress aggravates cognitive decline and the onset and progression of beta amyloid pathology in a mouse model of Alzheimer's disease.

Neurobiol Aging 2019 Jan 30;77:66-86. Epub 2019 Jan 30.

Department of Neuroscience, Canadian Centre for Behavioural Neuroscience (CCBN), University of Lethbridge, Lethbridge, Alberta, Canada. Electronic address:

Environmental distresses occurring during the sensitive periods of early life may exacerbate the vulnerability to develop physical and mental diseases in old age. Studies have shown the impact of prenatal stress (PS) on the endocrine development and reprogramming of hypothalamic-pituitary-adrenal axis functions in association with cognitive development and susceptibility to neuropsychiatric diseases. Long-term exposure to glucocorticoids can damage the brain and intensify the progression of Alzheimer's disease (AD)-like neuropathological changes, especially in females. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.019DOI Listing
January 2019

Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults: a monozygotic twin study.

Neurobiol Aging 2019 Jan 21;77:58-65. Epub 2019 Jan 21.

Department of Neurology & Alzheimer Center, VU University Medical Center, Neuroscience Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, the Netherlands.

Amyloid pathology in cognitively normal older adults has been associated with low memory performance and cognitive complaints, but findings are conflicting. Using a monozygotic twin design, we further explored this relation. We investigated 199 cognitively normal older adults (96 twin pairs) and assessed cognitive performance, cognitive complaints, and amyloid pathology on positron emission tomography and in the cerebrospinal fluid (CSF). Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.006DOI Listing
January 2019

Associations of amygdala volume and shape with transactive response DNA-binding protein 43 (TDP-43) pathology in a community cohort of older adults.

Neurobiol Aging 2019 Jan 31;77:104-111. Epub 2019 Jan 31.

Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, USA. Electronic address:

Transactive response DNA-binding protein 43 (TDP-43) pathology is common in old age and is strongly associated with cognitive decline and dementia above and beyond contributions from other neuropathologies. TDP-43 pathology in aging typically originates in the amygdala, a brain region also affected by other age-related neuropathologies such as Alzheimer's pathology. The purpose of this study was two-fold: to determine the independent effects of TDP-43 pathology on the volume, as well as shape, of the amygdala in a community cohort of older adults, and to determine the contribution of amygdala volume to the variance of the rate of cognitive decline after accounting for the contributions of neuropathologies and demographics. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.022DOI Listing
January 2019

Associations of exercise, nutritional status, and smoking with cognitive decline among older adults in Taiwan: Results of a longitudinal population-based study.

Arch Gerontol Geriatr 2019 Feb 6;82:133-138. Epub 2019 Feb 6.

Department of Health Management, I-Shou University, Kaohsiung, Taiwan.

This study aimed to explore the long-term effects of exercise, smoking, and nutritional status on cognitive reserve and changes in cognitive function among Taiwanese adults aged ≥65 years. Data were obtained from the Taiwan Longitudinal Study of Aging, a national representative population-based cohort study. Results showed that the average baseline scores on the Short Portable Mental Status Questionnaire (SPMSQ) and Mini-Nutritional Assessment (MNA) were 9. Read More

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http://dx.doi.org/10.1016/j.archger.2018.12.008DOI Listing
February 2019

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics.

Kidney Int 2019 Mar;95(3):624-635

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK; Division of Medicine and Manchester Heart Centre, Manchester University National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms of kidney aging. We sought to define the signatures of age on the renal transcriptome using 563 human kidneys. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.029DOI Listing

Kidney aging: an irresistible slope.

Authors:
Imari Mimura

Kidney Int 2019 Mar;95(3):492-494

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. Electronic address:

Kidney aging is a multifactorial process. Using genome-wide database analysis, Rowland et al. identified testis-specific Y-encoded-like protein 5 as a candidate age-related renal gene, and reported that with aging, testis-specific Y-encoded-like protein 5 expression decreases in response to increased testis-specific Y-encoded-like protein 5 promoter methylation. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.036DOI Listing

Loss of Hepatic Oscillatory Fed microRNAs Abrogates Refed Transition and Causes Liver Dysfunctions.

Cell Rep 2019 Feb;26(8):2212-2226.e7

Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India. Electronic address:

Inability to mediate fed-fast transitions in the liver is known to cause metabolic dysfunctions and diseases. Intuitively, a failure to inhibit futile translation of state-specific transcripts during fed-fast cycles would abrogate dynamic physiological transitions. Here, we have discovered hepatic fed microRNAs that target fasting-induced genes and are essential for a refed transition. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.087DOI Listing
February 2019

Association between circadian rhythms and neurodegenerative diseases.

Lancet Neurol 2019 Mar 12;18(3):307-318. Epub 2019 Feb 12.

Department of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA; San Francisco VA Medical Center, San Francisco, CA, USA.

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30461-7DOI Listing

Mobile health for older adult patients: Using an aging barriers framework to classify usability problems.

Int J Med Inform 2019 Apr 15;124:68-77. Epub 2019 Jan 15.

Amsterdam UMC, University of Amsterdam, Department of Medical Informatics, Center for Human Factors Engineering of Health Information Technology (HIT-Lab), the Netherlands; Amsterdam UMC, Department of Medical Informatics, Amsterdam Public Health Research Institute, Meibergdreef 9, Amsterdam, the Netherlands.

Background: With populations aging, digital health tools and mobile health applications (mHealth) are becoming more common to assist older people in independent living and self-management of (chronic) illnesses. These mHealth services can be beneficial to older patients, provided that they are adjusted to their needs and characteristics, as the current mHealth landscape lacks user-friendly services for this target group. Understanding of intrinsic aging barriers, which cause and impact usability problems older patients encounter, is needed to achieve this. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2019.01.006DOI Listing

Training interventions to improve general hospital care for older people with cognitive impairment: systematic review.

Br J Psychiatry 2019 Feb 20:1-12. Epub 2019 Feb 20.

Professor of Primary Care and Ageing,Institute of Health and Society; andDirector,Newcastle Institute for Ageing,Newcastle University,UK.

Background: In response to increasing numbers of older people in general hospitals who have cognitive impairment such as dementia and delirium, many hospitals have developed education and training programmes to prepare staff for this area of clinical practice.AimsTo review the evidence on educational interventions on hospital care for older people with cognitive impairment.

Method: A mixed methods systematic review and narrative synthesis was undertaken. Read More

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http://dx.doi.org/10.1192/bjp.2019.29DOI Listing
February 2019

NF90 regulation of immune factor expression in response to malaria antigens.

Cell Cycle 2019 Feb 20. Epub 2019 Feb 20.

a Laboratory of Genetics and Genomics , National Institute on Aging Intramural Research Program, National Institutes of Health , Baltimore , MD , US.

Nuclear factor 90 (NF90) is a dual DNA- and RNA-binding protein expressed ubiquitously in mammalian cells, including monocytes. Here, to elucidate the function of NF90 in the immune response, we analyzed systematically its influence on gene expression programs in the human monocytic cell line THP-1 expressing normal or reduced NF90 levels. RNA sequencing analysis revealed many mRNAs showing differential abundance in NF90-silenced cells, many of them encoding proteins implicated in the response to immune stimuli and malaria infection. Read More

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http://dx.doi.org/10.1080/15384101.2019.1580496DOI Listing
February 2019

Soy isoflavones protect against oxidative stress and diminish apoptosis in ovary of middle-aged female rats.

Gynecol Endocrinol 2019 Feb 20:1-5. Epub 2019 Feb 20.

a Department of Morphology and Genetics , Federal University of São Paulo , São Paulo , Brazil.

Ovarian aging is characterized by declines in follicular reserve and oocyte quality due, in part, to increased oxidative stress and apoptosis. Soy isoflavones (ISOs) have been shown to improve ovarian lifespan by acting as antioxidant and antiapoptotic agents. We aimed at evaluating whether ISOs could modulate oxidative stress and reduce apoptosis and improve ovarian follicle survival in middle-aged female rats. Read More

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http://dx.doi.org/10.1080/09513590.2018.1559287DOI Listing
February 2019

Cognitive effects of video games in older adults and their moderators: a systematic review with meta-analysis and meta-regression.

Aging Ment Health 2019 Feb 20:1-16. Epub 2019 Feb 20.

a Exercise and Sport Science, Faculty of Health Sciences , University of Sydney , Sydney , Australia.

The growing interest in preserving cognition through video games in the ageing population is evidenced by its wealth of literature. However, there has been a lack of consensus on video games efficacy and even limited understanding on the factors moderating its effectiveness. The present review sought to evaluate video game effects, relative to no-game control condition, on cognitive functions in older adults. Read More

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http://dx.doi.org/10.1080/13607863.2019.1574710DOI Listing
February 2019

Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Biomedical Department, Centre Scientifique de Monaco, Monaco, Principality of Monaco.

Most cases of medulloblastoma (MB) occur in young children. While the overall survival rate can be relatively high, current treatments combining surgery, chemo- and radiotherapy are very destructive for patient development and quality of life. Moreover, aggressive forms and recurrences of MB cannot be controlled by classical therapies. Read More

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http://dx.doi.org/10.1111/jcmm.14176DOI Listing
February 2019

Testing psychometric properties of a new instrument 'Promoting Active Ageing in Older People with Mental Disorders Scale' from a cross-sectional study.

Psychogeriatrics 2019 Feb 19. Epub 2019 Feb 19.

School of Nursing and Midwifery, The University of Newcastle, Callaghan, New South Wales, Australia.

Background: There is no instrument that measures the promotion of active ageing or the factors that influence the promotion of active ageing in older people with mental disorders living in the community. This study aimed to examine psychometric properties of a new survey instrument.

Methods: A mixed methods exploratory sequential design was used incorporating a cross-sectional survey. Read More

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http://dx.doi.org/10.1111/psyg.12415DOI Listing
February 2019

Development of the Australian Ageing Semantic Differential, a new instrument for measuring Australian medical student attitudes towards older people.

Australas J Ageing 2019 Feb 19. Epub 2019 Feb 19.

Health Care of Older People, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.

Objective: This study outlines development of an instrument for measuring attitudes of medical students towards older people, the Australian Ageing Semantic Differential (AASD).

Methods: Words for AASD scales were derived from the reflections of 151 third year medical students attending two Australian medical schools. A pilot study of the AASD was then undertaken with third year students at another medical school to confirm usability and reliability of the instrument. Read More

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http://dx.doi.org/10.1111/ajag.12627DOI Listing
February 2019

Comorbidity of reading disabilities and ADHD: Structural and functional brain characteristics.

Hum Brain Mapp 2019 Feb 19. Epub 2019 Feb 19.

Laboratories of Cognitive Neuroscience, Division of Developmental Medicine, Department of Medicine, Boston Children's Hospital, Boston, Massachusetts.

Reading disabilities (RD) and attention-deficit/hyperactivity disorder (ADHD) are two of the most common developmental disorders. RD and ADHD frequently co-occur, which raises questions about how the disorders interact and to what extent they can be differentiated. To date, the underlying neural mechanisms leading to RD-ADHD comorbidity (COM) are not understood. Read More

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http://dx.doi.org/10.1002/hbm.24552DOI Listing
February 2019

Experimental study on the antioxidant activity of Malus hupehensis (Pamp.) Rehd extracts in vitro and in vivo.

J Cell Biochem 2019 Feb 19. Epub 2019 Feb 19.

Shaanxi Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.

Extracts of Malus hupehensis (Pamp.) Rehder, containing flavonoids with good antioxidant and antiliver injury properties, possess various biological activities. The aim of this study was to explore the antioxidant activity of these extracts in vitro and in vivo. Read More

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http://dx.doi.org/10.1002/jcb.28469DOI Listing
February 2019

Metformin protects PC12 cells and hippocampal neurons from H O -induced oxidative damage through activation of AMPK pathway.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Center of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China.

Metformin, a first line anti type 2 diabetes drug, has recently been shown to extend lifespan in various species, and therefore, became the first antiaging drug in clinical trial. Oxidative stress due to excess reactive oxygen species (ROS) is considered to be an important factor in aging and related disease, such as Alzheimer's disease (AD). However, the antioxidative effects of metformin and its underlying mechanisms in neuronal cells is not known. Read More

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http://dx.doi.org/10.1002/jcp.28337DOI Listing
February 2019

Treatment Decisions for Metastatic Clear Cell Renal Cell Carcinoma in Older Patients: The Role of TKIs and Immune Checkpoint Inhibitors.

Drugs Aging 2019 Feb 20. Epub 2019 Feb 20.

Division of Medical Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Dr, Suite 2161, Salt Lake City, UT, 84112, USA.

Given the underrepresentation of older patients in registration trials for metastatic renal cell carcinoma (mRCC), data to support the use of any particular systemic therapy over others, based on age, is limited. This is further complicated by clinical trials not commonly reporting adverse events by age. Thus, recommendations on treatment of older patients with mRCC are generally extrapolated from data on younger patients enrolled in these trials, which may not be ideal as many older patients are frail, have age-related organ dysfunction, or have multiple medical co-morbidities. Read More

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http://dx.doi.org/10.1007/s40266-019-00644-1DOI Listing
February 2019

A randomized double-blinded placebo controlled trial of ergocalciferol 40,000 versus 100,000 IU per week for vitamin D inadequacy in institutionalized postmenopausal women.

Aging Clin Exp Res 2019 Feb 19. Epub 2019 Feb 19.

Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and Phramongkutklao College of Medicine, 315 Ratchawithi Road, Ratchathewi district, 10400, Bangkok, Thailand.

Background: Vitamin D inadequacy is common in institutionalized post-menopausal women who are at the highest risk for osteoporotic fracture.

Aim: To evaluate efficacy and safety of ergocalciferol 40,000 versus 100,000 IU per week for 12 weeks for vitamin D inadequacy in institutionalized postmenopausal women.

Method: A randomized double-blinded placebo-controlled trial was conducted in 94 institutionalized subjects with baseline 25(OH)D levels < 30 ng/mL. Read More

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http://dx.doi.org/10.1007/s40520-019-01151-4DOI Listing
February 2019

The role of omega-3 in the prevention and treatment of sarcopenia.

Aging Clin Exp Res 2019 Feb 19. Epub 2019 Feb 19.

Division of Gerontology and Geriatrics, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.

Sarcopenia is a geriatric syndrome with increasing importance due to the aging of the population. It is known to impose a major burden in terms of morbidity, mortality and socio-economic costs. Therefore, adequate preventive and treatment strategies are required. Read More

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http://link.springer.com/10.1007/s40520-019-01146-1
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http://dx.doi.org/10.1007/s40520-019-01146-1DOI Listing
February 2019
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Rural-urban differences in health behaviors and outcomes among older, overweight, long-term cancer survivors in the RENEW randomized control trial.

Cancer Causes Control 2019 Feb 19. Epub 2019 Feb 19.

Department of Nutrition Sciences, UAB, Birmingham, AL, USA.

Purpose: Rural cancer survivors (RCS) have poorer health outcomes and face multiple challenges-older age, and limited transportation, education, income, and healthcare access. Yet, RCS are understudied. The Reach-out to ENhancE Wellness(RENEW) trial, a home-based, diet and exercise intervention among 641 breast, prostate, and colorectal cancer survivors addressed many of these challenges. Read More

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http://dx.doi.org/10.1007/s10552-019-01141-xDOI Listing
February 2019

Clinical purpura and elastosis and their correlation with skin tears in an aged population.

Arch Dermatol Res 2019 Feb 20. Epub 2019 Feb 20.

School of Public Health, Curtin University, Kent St, Bentley, WA, 6102, Australia.

The previous research reported the results of a prospect cohort study that used logistic regression analysis to construct a risk prediction model for skin tears in individuals aged over 65 years. The model identified three baseline individual characteristics (male gender, history of STs, and history of falls) and two baseline skin manifestations (purpura and elastosis) that predicted the risk of dorsal forearm skin tears. This paper outlines the relationships between baseline skin manifestations and the risk of skin tears. Read More

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http://dx.doi.org/10.1007/s00403-019-01899-9DOI Listing
February 2019

Single finger movements in the aging hand: changes in finger independence, muscle activation patterns and tendon displacement in older adults.

Exp Brain Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

With aging, hand mobility and manual dexterity decline, even under healthy circumstances. To assess how aging affects finger movement control, we compared elderly and young subjects with respect to (1) finger movement independence, (2) neural control of extrinsic finger muscles and (3) finger tendon displacements during single finger flexion. In twelve healthy older (age 68-84) and nine young (age 22-29) subjects, finger kinematics were measured to assess finger movement enslaving and the range of independent finger movement. Read More

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http://dx.doi.org/10.1007/s00221-019-05487-1DOI Listing
February 2019

MRE11 UFMylation promotes ATM activation.

Nucleic Acids Res 2019 Feb 20. Epub 2019 Feb 20.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University School of Medicine, Shenzhen, Guangdong 518060, China.

A proper DNA damage response (DDR) is essential to maintain genome integrity and prevent tumorigenesis. DNA double-strand breaks (DSBs) are the most toxic DNA lesion and their repair is orchestrated by the ATM kinase. ATM is activated via the MRE11-RAD50-NBS1 (MRN) complex along with its autophosphorylation at S1981 and acetylation at K3106. Read More

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http://dx.doi.org/10.1093/nar/gkz110DOI Listing
February 2019

Intrinsic default - executive coupling of the creative aging brain.

Soc Cogn Affect Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, York University, Toronto, ON Canada.

Creativity refers to the ability to generate novel associations and has been linked to better problem-solving and real-world functional abilities. In younger adults, creative cognition has been associated with functional connectivity among brain networks implicated in executive control (fronto-parietal and salience networks) and associative or elaborative processing (default network). Here, we investigate whether creativity is associated with the intrinsic network architecture of the brain and how these associations may differ for younger and older adults. Read More

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http://dx.doi.org/10.1093/scan/nsz013DOI Listing
February 2019