478,406 results match your criteria Ageing & Society[Journal]


Accelerated brain aging in sepsis survivors with cognitive long-term impairment.

Eur J Neurosci 2020 Jun 4. Epub 2020 Jun 4.

Moritz Klinik Bad Klosterlausnitz, Hermann-Sachse-Strasse 46, 07639, Bad Klosterlausnitz, Germany.

In the last years, cognitive impairment was emphasized to be a prominent long-term sequela of sepsis. The level of cognitive impairment is comparable with that in mild cognitive impairment (MCI) patients. Whether sepsis survivors also show a comparable brain atrophy is still unclear. Read More

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http://dx.doi.org/10.1111/ejn.14850DOI Listing

Sex Differences in 11-Oxygenated Androgen Patterns across Adulthood.

J Clin Endocrinol Metab 2020 Jun 4. Epub 2020 Jun 4.

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor.

Context: The gonads are the major source of sex steroids during reproductive ages. The gonadal function declines abruptly in women and gradually in men. The adrenals produce 11-oxygenated androgens (11-oxyandrogens), which start rising during adrenarche. Read More

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http://dx.doi.org/10.1210/clinem/dgaa343DOI Listing

Dementia is associated with poorer quality of care and outcomes after stroke: An Observational Study.

J Gerontol A Biol Sci Med Sci 2020 Jun 4. Epub 2020 Jun 4.

Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia.

Background: To determine if pre-existing dementia is associated with poorer quality of care and outcomes after stroke in the acute hospital phase.

Methods: This was a retrospective analysis of pooled data from the Australian Stroke Foundation national audit conducted in 2015 and 2017. Dementia status was obtained from the medical records. Read More

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http://dx.doi.org/10.1093/gerona/glaa139DOI Listing

Machine Learning in Aging: An Example of Developing Prediction Models for Serious Fall Injury in Older Adults.

J Gerontol A Biol Sci Med Sci 2020 Jun 4. Epub 2020 Jun 4.

Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC.

Background: Advances in computational algorithms and the availability of large datasets with clinically relevant characteristics provide an opportunity to develop machine learning prediction models to aid in diagnosis, prognosis, and treatment of older adults. Some studies have employed machine learning methods for prediction modeling, but skepticism of these methods remains due to lack of reproducibility and difficulty understanding the complex algorithms that underlie models. We aim to provide an overview of two common machine learning methods: decision tree and random forest. Read More

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http://dx.doi.org/10.1093/gerona/glaa138DOI Listing

Systematic manipulations of the biological stress systems result in sex-specific compensatory stress responses and negative mood outcomes.

Neuropsychopharmacology 2020 Jun 4. Epub 2020 Jun 4.

Faculty of Medicine, McGill Centre for Studies in Aging, McGill University, Montreal, QC, Canada.

Women are twice as likely as men to be diagnosed with anxiety and mood disorders. One potential underlying mechanism is sex differences in physiological and psychological responses to stress; however, no studies to date have investigated this proposed mechanism experimentally. In a double-blind, placebo-controlled design, pharmacological challenges were administered to individually suppress the hypothalamic-pituitary-adrenal (HPA) axis, or the sympathetic nervous system (SNS) prior to stress exposure, to investigate sex differences in the resulting cross talk among the physiological and psychological stress responses. Read More

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http://dx.doi.org/10.1038/s41386-020-0726-8DOI Listing

"Not Everybody's an Athlete, But They Certainly Can Move": Facilitators of Physical Activity Maintenance in Older Adults in a Northern and Rural Setting.

J Aging Phys Act 2020 Jun 4:1-10. Epub 2020 Jun 4.

Although the benefits of maintaining a physical activity regime for older adults are well known, it is unclear how programs and facilities can best support long-term participation. The purpose of this study is to determine the facilitating factors of physical activity maintenance in older adults at individual, program, and community levels. Nine semistructured interviews were conducted with individuals aged 60 years and older and long-term participants (>6 months) in community-based group exercise at a clinical wellness facility in northern British Columbia, Canada. Read More

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http://dx.doi.org/10.1123/japa.2019-0393DOI Listing

Reducing Sitting Time in Obese Older Adults: The I-STAND Randomized Controlled Trial.

J Aging Phys Act 2020 Jun 4:1-11. Epub 2020 Jun 4.

Background: The authors tested the efficacy of the "I-STAND" intervention for reducing sitting time, a novel and potentially health-promoting approach, in older adults with obesity.

Methods: The authors recruited 60 people (mean age = 68 ± 4.9 years, 68% female, 86% White; mean body mass index = 35. Read More

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http://dx.doi.org/10.1123/japa.2019-0470DOI Listing

A Comparison of Cardiopulmonary Exercise Testing and Field Walking Tests in Community-Dwelling Older Adults With Mild-to-Moderate Alzheimer's Dementia.

J Aging Phys Act 2020 Jun 4. Epub 2020 Jun 4.

The purpose of this study was to investigate the relationships among peak exercise parameters on 6-min walk test, shuttle walk test, and laboratory-based cardiopulmonary exercise testing in persons with Alzheimer's dementia. This study is a cross-sectional analysis of the baseline data of 90 participants (age 77.1 [6. Read More

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http://dx.doi.org/10.1123/japa.2019-0387DOI Listing

Is Stretching Exercise An Adequate Control Group in Clinical Trials Aimed at Improving Physical Fitness and Function of Older Adults? A Systematic Review and Meta-Analysis.

J Aging Phys Act 2020 Jun 4:1-22. Epub 2020 Jun 4.

This study aimed to determine if stretching exercise can be implemented as an adequate control therapy in exercise randomized controlled trials aimed at improving physical fitness and physical function in older adults. Five electronic databases were systematically searched for randomized controlled trials focused in the physical fitness and function of older adults using stretching exercise as control group. The methodological quality was assessed and a meta-analysis was carried out. Read More

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http://dx.doi.org/10.1123/japa.2019-0257DOI Listing

Can Insoles Be Used to Improve Static and Dynamic Balance of Community-Dwelling Older Adults? A Systematic Review on Recent Advances and Future Perspectives.

J Aging Phys Act 2020 Jun 4:1-16. Epub 2020 Jun 4.

This systematic review investigated the effects of orthopedic, vibrating, and textured insoles on the postural balance of community-dwelling older adults. Articles published in English from 1999 to 2019 investigating the effects of (a) orthopedic, (b) vibrating, and (c) textured insoles on static and dynamic balance in community-dwelling older adults were considered. Twenty-four trials with a total of 634 older adults were identified. Read More

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http://dx.doi.org/10.1123/japa.2019-0293DOI Listing

Naringin nano-ethosomal novel sunscreen creams: Development and performance evaluation.

Colloids Surf B Biointerfaces 2020 May 12;193:111122. Epub 2020 May 12.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576 104, India. Electronic address:

Long term exposure of skin to UV rays produces detrimental effects such as premature skin-ageing and skin cancer. Although, zinc oxide (ZnO) and titanium dioxide (TiO) are good sunscreen agents, they do not provide highly efficient UV radiation protection and antioxidant and anti-aging effects. The present study was aimed at developing and characterizing ethosomes loaded with naringin and then to incorporate them into sunscreen creams containing nano-ZnO and -TiO to achieve adequate skin penetration and skin retention so as to scavenge the free radicals by virtue of naringin's antioxidant property. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111122DOI Listing

A web-based survey of reproductive awareness and choices in women with endometriosis.

Eur J Obstet Gynecol Reprod Biol 2020 May 12;251:106-113. Epub 2020 May 12.

Reproductive Medicine Unit, Division of Gynaecology, Geneva University Hospitals and the Faculty of Medicine of University of Geneva, Switzerland. Electronic address:

Objective: Our aim was to study fertility issues, attitudes towards reproductive techniques and fertility preservation options in women of reproductive age with endometriosis.

Study Design: In 2018 we conducted a web-based survey on fertility issues in women aged 18-40 years with endometriosis. Participants were recruited via advertisements on social media and local endometriosis support groups. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.012DOI Listing

Postural stability after treadmill and overground walking in young and elderly.

Gait Posture 2020 May 16;80:84-89. Epub 2020 May 16.

Department of Natural Sciences in Kinanthropology, Faculty of Physical Culture, Palacky University Olomouc, třída Míru 117, 771 11 Olomouc, Czech Republic.

Background: Ageing commonly disrupts the balance control and compensatory postural responses that contribute to maintaining balance and preventing falls during perturbation of posture. Improvement of compensatory postural responses during walking is one of the main goals in fall prevention programs which often include treadmill walking training. However, during treadmill walking, there is a sensory (visualsomatosensory and vestibular-somatosensory) conflict that can evoke aftereffects of self-motion sensation and could alter postural stability after training. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.014DOI Listing

Differences in time-based task characteristics help to explain the age-prospective memory paradox.

Cognition 2020 Jun 1;202:104305. Epub 2020 Jun 1.

Australian Catholic University, Melbourne, Australia.

Prior prospective memory (PM) research shows paradoxical findings-young adults outperform older adults in laboratory settings, but the reverse is found in naturalistic settings. Moreover, young-old outperform old-old adults in laboratory settings, but show no age differences in naturalistic settings. Here we highlight how time-based task characteristics have differed systematically between studies conducted in laboratory (time-interval cues) and naturalistic settings (time-of-day cues) and argue that this apparent paradox is a function of comparing disparate task types. Read More

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http://dx.doi.org/10.1016/j.cognition.2020.104305DOI Listing

Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants.

Neurobiol Aging 2020 Apr 24;94:7-14. Epub 2020 Apr 24.

Department of Chemical Engineering, School for Engineering, Matter, Transport and Energy, Arizona State University, Tempe, AZ, USA. Electronic address:

Reagents that can selectively recognize specific toxic tau variants associated with onset and progression of Alzheimer's disease (AD) and other tauopathies can be effective diagnostic and therapeutic tools. We utilized a novel atomic force microscopy-based biopanning protocol to isolate antibody fragments (single chain variable fragments, scFvs) that selectively bind tau variants present in human AD but not cognitively normal age-matched brain tissue. We identified 6 scFvs [Alzheimer's disease tau (ADT)-1 through 6] that readily distinguished between AD and control tissue and sera samples. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.014DOI Listing

Cognitive markers of dementia risk in middle-aged women with bilateral salpingo-oophorectomy prior to menopause.

Neurobiol Aging 2020 Apr 29;94:1-6. Epub 2020 Apr 29.

Department of Psychology, University of Toronto, Toronto, Ontario, Canada; Rotman Research Institute, Toronto, Ontario, Canada; Tema Genus, Linköping University, Linköping, Sweden.

Oophorectomy prior to menopause is associated with late-life dementia. Memory decline may start within 6 months after oophorectomy in middle-aged women, suggested by lower verbal and working memory performance. Unknown is whether such changes persist beyond 6 months, and whether they are reversed by estradiol. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.019DOI Listing

Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats.

Biomed Pharmacother 2020 Jun 1;128:110304. Epub 2020 Jun 1.

Department of Pharmacology, Guangdong Medical University, Zhanjiang, Guangdong, 524023, PR China. Electronic address:

Background And Aims: Aging-induced bone loss is a multifactorial, age-related, and progressive phenomenon among the general population and may further progress to osteoporosis and increase the risk of fractures. Cycloastragenol (CAG), currently the only compound reported that activates human telomerase, is thought to be able to alleviate or delay the symptoms of aging and chronic diseases. Previous research has suggested that CAG may have the potential to alleviate age-related bone loss. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110304DOI Listing

The critical impacts of small RNA biogenesis proteins on aging, longevity and age-related diseases.

Ageing Res Rev 2020 Jun 1:101087. Epub 2020 Jun 1.

Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya St., 167982, Syktyvkar, Russian Federation; Pitirim Sorokin Syktyvkar State University, 55 Oktyabrsky Prosp., 167001, Syktyvkar, Russian Federation; Laboratory of Post-Genomic Research, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov St., 119991, Moscow, Russian Federation; Moscow Institute of Physics and Technology, 9 Institutskiy Per., 141701, Dolgoprudny, Moscow Region, Russian Federation. Electronic address:

Small RNAs and enzymes that provide their biogenesis and functioning are involved in the organism development and coordination of biological processes, including metabolism, maintaining genome integrity, immune and stress responses. In this review, we focused on the role of small RNA biogenesis proteins in determining the aging and longevity of animals and human. A number of studies have revealed that changes in expression profiles of key enzymes, in particular proteins of the Drosha, Dicer and Argonaute families, are associated with the aging process, as well as with some age-related diseases and progeroid syndromes. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101087DOI Listing

Mitochondrial dysfunction induced by variation in the non-coding genome -A proposed workflow to improve diagnostics.

Mitochondrion 2020 Jun 1. Epub 2020 Jun 1.

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark. Electronic address:

Mitochondrial disorders are one of the most common inherited metabolic disorders and are caused by variants in nuclear genes or the mitochondrial genome. Additionally, there is a large group of patients displaying clinical symptoms, where the genetic background is unknown. Mitochondrial disorders have a huge variety in their clinical presentation, making diagnostics challenging. Read More

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http://dx.doi.org/10.1016/j.mito.2020.05.013DOI Listing

Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements.

Life Sci 2020 Jun 1:117883. Epub 2020 Jun 1.

Gottfried Schatz Research Centre for Cell Signalling, Metabolism and Aging, Medical University of Graz, Graz, Austria.. Electronic address:

The present pandemic of SARS-CoV-2 has been a tough task for the whole world to deal with. With the absence of specific drugs or vaccines against SARS-CoV-2, the situation is very difficult to control. Apart from the absence of specific therapies, the lack of knowledge about potential therapeutic targets and individual perception is adding to the complications. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117883DOI Listing

THE MIDLIFE TRANSITION AND THE RISK OF CARDIOVASCULAR DISEASE AND CANCER I: MAGNITUDE AND MECHANISMS.

Am J Obstet Gynecol 2020 Jun 1. Epub 2020 Jun 1.

Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Heart disease and cancer are the leading causes of death in the U.S. In women the clinical appearance of both entities- coronary heart disease and cancer (breast, endometrium and ovary) escalate during the decades of the midlife transition encompassing the menopause. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.051DOI Listing

Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging.

Neuropharmacology 2020 Jun 1:108173. Epub 2020 Jun 1.

Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea; Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, Republic of Korea. Electronic address:

Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms. Despite the remarkable improvements in the management of PD in recent decades, many patients remain significantly disabled. Metformin is a primary medication for the management of type 2 diabetes. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2020.108173DOI Listing

Reduced telomere shortening in lifelong trained male football players compared to age-matched inactive controls.

Prog Cardiovasc Dis 2020 Jun 1. Epub 2020 Jun 1.

Department of Sports Science and Clinical Biomechanics, SDU Sport and Health Sciences Cluster, University of Southern Denmark, Odense 3450, Denmark; Sport and Health Sciences, St Luke's Campus, University of Exeter, Exeter EX1 6JA, United Kingdom; Shanghai University of Sport, Shanghai, China. Electronic address:

Aims: Current evidence points to cellular anti-ageing effects of regular endurance training which may differ from other sport modalities. Effects of football training on markers of cell senescence have not been tested.

Methods: One hundred and forty healthy, non-smoking men participated in the study, including young elite football players aged 18-30 years (YF, n = 35, 21. Read More

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http://dx.doi.org/10.1016/j.pcad.2020.05.009DOI Listing

"We are Alone in This Battle": A Framework for a Coordinated Response to COVID-19 in Nursing Homes.

J Aging Soc Policy 2020 Jun 4:1-7. Epub 2020 Jun 4.

Marian S. Ware Professor in Gerontology, Director of the NewCourtland Center for Transitions and Health, University of Pennsylvania , Philadelphia, Pennsylvania, USA.

As of May 2020, nursing home residents account for a staggering one-third of the more than 80,000 deaths due to COVID-19 in the U.S. This pandemic has resulted in unprecedented threats to achieving and sustaining care quality even in the best nursing homes, requiring active engagement of nursing home leaders in developing solutions responsive to the unprecedented threats to quality standards of care delivery during the pandemic. Read More

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http://dx.doi.org/10.1080/08959420.2020.1773190DOI Listing

COVID-19: Implications for the Support of People with Social Care Needs in England.

J Aging Soc Policy 2020 Jun 4:1-8. Epub 2020 Jun 4.

Associate Professorial Research Fellow, Care Policy and Evaluation Centre, London School of Economics and Political Science , London, UK.

This perspective examines the challenge posed by COVID-19 for social care services in England and describes responses to this challenge. People with social care needs experience increased risks of death and deteriorating physical and mental health with COVID-19. Social isolation introduced to reduce COVID-19 transmission may adversely affect well-being. Read More

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http://dx.doi.org/10.1080/08959420.2020.1759759DOI Listing

Using Focus Group Feedback to Identify Patient-Centered Initiatives for Older Persons with HIV.

Clin Gerontol 2020 Jun 4:1-12. Epub 2020 Jun 4.

Department of Medicine, Weill Cornell Medicine , New York, New York, USA.

Objectives: This study assessed how few community-based programs target older people living with HIV.

Methods: We conducted four focus groups comprised of people 50 and older with HIV (N = 32; gay/bisexual men, heterosexual men, women, and Spanish-speakers) to inform HIV program development by exploring the services in which participants were actively involved, along with the services they wanted to receive.

Results: Using inductive thematic qualitative analysis, four themes were identified pertaining to program development: (a) types of currently utilized HIV service organizations; (b) dissatisfaction with HIV programming and services; (c) participants' preferred programming, courses, groups, or activities; and (d) desire to serve as peer mentors. Read More

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http://dx.doi.org/10.1080/07317115.2020.1769245DOI Listing

Testosterone, sex steroids, and aging in neurodegenerative disease after acquired brain injury: a commentary.

Authors:
Mark J Ashley

Brain Inj 2020 Jun 4:1-5. Epub 2020 Jun 4.

Centre for Neuro Skills , Bakersfield, CA, USA.

Primary Objective: Traumatic brain injury (TBI) is associated with higher incidence of neurodegenerative disease and the effects of aging appear more pronounced after TBI. This paper examines the potential interaction of aging, TBI, and change in male testosterone production.

Methods And Procedures: An abbreviated review of literature documenting hypogonadism after TBI is provided. Read More

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http://dx.doi.org/10.1080/02699052.2020.1763461DOI Listing

Major Depressive Disorder and Impaired Health-related Quality of Life among US Older Adults.

Int J Geriatr Psychiatry 2020 Jun 4. Epub 2020 Jun 4.

Department of Psychiatry, School of Medicine, University of Connecticut, Farmington, Connecticut.

Objectives: To examine the association of current and past major depressive disorder (MDD) and measures of health-related quality of life (HRQOL) in a nationally representative sample of older adults.

Methods: Cross-sectional analysis of the 2012-2013 National Epidemiological Survey on Alcohol and Related Conditions Wave III (NESARC-III) was used. NESARC-III is a nationally representative health interview survey on substance use and mental health in the US, and we limited our sample to survey respondents aged 65 or older (n = 5806 unweighted). Read More

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http://dx.doi.org/10.1002/gps.5356DOI Listing

Retirees' perceptions of goal setting: A qualitative study.

Australas J Ageing 2020 Jun 4. Epub 2020 Jun 4.

ARC Centre of Excellence in Population Ageing Research (CEPAR), Sydney, New South Wales, Australia.

Objective: To investigate the language and meanings that retirees give to goals, including their perceptions of the benefits and limitations of pursuing goals in retirement.

Methods: In-depth interviews and mini-group discussions were conducted with 60 community-dwelling Australian retirees aged 57 to 88 years. Data were transcribed and analysed thematically. Read More

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http://dx.doi.org/10.1111/ajag.12798DOI Listing

AMYOTROPHIC LATERAL SCLEROSIS, CANCER, AUTOIMMUNITY AND METABOLIC DISORDERS: AN UNSOLVED TANTALIZING CHALLENGE.

Br J Pharmacol 2020 Jun 4. Epub 2020 Jun 4.

Centro de Investigación en Red de Enfermedades Neurodegenerativas, CIBERNED. Instituto Carlos III, Madrid, Spain.

Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknown pathogenesis that progresses rapidly, has attracted an increased amount of scholarly interest in recent years. The current conception of ALS has transitioned into a more complex theory in which individual genetic risk, ageing, and environmental factors interact, leading to disease onset in subjects in whom the sum of these factors reach a determined threshold. Based on this conceptualization, the environmental conditions, particularly those that are potentially modifiable, are becoming increasingly relevant. Read More

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http://dx.doi.org/10.1111/bph.15151DOI Listing

Householders' perception about sustaining the useful life of long-lasting insecticide-treated nets in Ghana.

Int Health 2020 Jun 4. Epub 2020 Jun 4.

Department of Planning and Sustainability, School of Geo-Sciences, University of Energy and Natural Resources. P.O.Box 214, Sunyani, Ghana.

Background: This article explores the multifaceted perceptions among householders about the care, efficacy and disposal of long-lasting insecticide-treated nets (LLINs), especially those regarding the end of the useful life of LLINs, and their implications for malaria control.

Methods: We used a cross-sectional qualitative design. Data were gathered in the Shai-Osudoku District in the Greater Accra Region of Ghana using focus group discussions and in-depth interviews. Read More

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http://dx.doi.org/10.1093/inthealth/ihaa019DOI Listing

Identification and management of young infants with possible serious bacterial infection where referral was not feasible in rural Lucknow district of Uttar Pradesh, India: An implementation research.

PLoS One 2020 4;15(6):e0234212. Epub 2020 Jun 4.

Department of Social and Preventive Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

Background: Based on World Health Organization guidelines, Government of India recommended management of possible serious bacterial infection (PSBI) in young infants up to two months of age on an outpatient basis where referral is not feasible. We implemented the guideline in program setting to increase access to treatment with high treatment success and low resultant mortality.

Methods: Implementation research was conducted in four rural blocks of Lucknow district in Uttar Pradesh, India. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234212PLOS

High rate of partner violence during pregnancy in eastern Ethiopia: Findings from a facility-based study.

PLoS One 2020 4;15(6):e0233907. Epub 2020 Jun 4.

Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.

Introduction: Intimate partner violence during pregnancy can contribute to maternal mortality and morbidity by limiting women's ability to receive maternal health services including antenatal care and skilled delivery care. In Ethiopia, evidence regarding intimate partner violence during pregnancy is limited, and no previous studies have been conducted in the Harari region. Therefore, this study aimed to investigate the prevalence and associated factors of intimate partner violence during pregnancy among women who had given birth in public hospitals in Harari regional state, eastern Ethiopia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233907PLOS

Long non-coding RNA SNHG1 activates HOXA1 expression via sponging miR-193a-5p in breast cancer progression.

Aging (Albany NY) 2020 Jun 3;12. Epub 2020 Jun 3.

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Breast cancer is the leading cause of cancer death in women worldwide. Long non-coding RNA small nucleolar RNA host gene 1 () has been reported to be involved in human diseases, including cancer. Here, we found that expression was significantly upregulated in human breast cancer tissues and cell lines. Read More

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http://dx.doi.org/10.18632/aging.103123DOI Listing

The circRNA circIFI30 promotes progression of triple-negative breast cancer and correlates with prognosis.

Aging (Albany NY) 2020 Jun 4;12. Epub 2020 Jun 4.

Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing, China.

Growing evidence suggests that circRNAs exert a critical role in tumorigenesis and cancer progression. To date, the molecular mechanisms underlying circRNAs in triple-negative breast cancer (TNBC) are still poorly known. Here, circRNA expression profile was investigated by RNA sequencing in TNBC tissues and matched para-carcinoma tissues. Read More

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http://dx.doi.org/10.18632/aging.103311DOI Listing

Interactive effect of C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia.

Aging (Albany NY) 2020 Jun 4;12. Epub 2020 Jun 4.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

The etiology of schizophrenia is still unknown, and the gene has been shown to be associated with SCZ. Previous studies have shown that patients with schizophrenia exhibit sex differences in symptoms and cognitive function. However, no study has been conducted to investigate the sex difference in the association between C677T polymorphism and symptoms and cognitive impairment in Chinese patients with schizophrenia. Read More

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http://dx.doi.org/10.18632/aging.103248DOI Listing

Investigating the Relationship between Menopause Specific Quality of Life and Perceived Social Support among Postmenopausal Women in Iran.

Exp Aging Res 2020 Jun 4:1-8. Epub 2020 Jun 4.

Student Research Committee, Neyshabur University of Medical Sciences , Neyshabur, Iran.

Background: The purpose of this research was to investigate the relationship between Menopause Specific Quality of Life (MENQOL), Perceived Social Support (PSS) and factors associated with MENQOL among a group of Iranian Postmenopausal women in 2018.

Methods: In this cross-sectional study 410 of Postmenopausal Iranian women in Neyshabur are examined. QOL was assessed using MENQOL questionnaire, and social support was assessed through administration of a modified Sarason's Social Support Questionnaire. Read More

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http://dx.doi.org/10.1080/0361073X.2020.1776020DOI Listing

Do older workers suffer more workplace injuries? A Systematic Review.

Int J Occup Saf Ergon 2020 Jun 4:1-56. Epub 2020 Jun 4.

Centro de Estudio del Trabajo y Factores Humanos, Facultad de Medicina, Universidad de Valparaíso, Valparaíso, Chile.

Aging populations are a dramatically-increased worldwide trend, both in developed and developing countries. This study examines the prevalence of fatal and non-fatal work-related injuries between young (under 45) and older workers (45 and above). A systematic literature review was used aimed at examining studies comparing safety outcomes, namely fatal and non-fatal injuries, between older and younger workers. Read More

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http://dx.doi.org/10.1080/10803548.2020.1763609DOI Listing

The Unique Challenges Faced by Assisted Living Communities to Meet Federal Guidelines for COVID-19.

J Aging Soc Policy 2020 Jun 4:1-9. Epub 2020 Jun 4.

Professor, School of Aging Studies, Florida Policy Exchange Center on Aging, University of South Florida , Tampa, Florida, USA.

This perspective addresses the challenges that assisted living (AL) providers face concerning federal guidelines to prevent increased spread of COVID-19. These challenges include restriction of family visitation, use of third-party providers as essential workers, staffing guidelines, transfer policies, and rural AL hospitalizations. To meet these challenges we recommend that AL providers incorporate digital technology to maintain family-resident communication. Read More

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http://dx.doi.org/10.1080/08959420.2020.1770037DOI Listing

Social support as a protective factor against the effect of grief reactions on depression for bereaved single older adults.

Authors:
Ruoxi Chen

Death Stud 2020 Jun 4:1-8. Epub 2020 Jun 4.

College of Health Sciences, University of Louisiana at Monroe, Monroe, Louisiana, USA.

This study tested the main effect model and the stress-buffering model of the mechanisms by which social support affects bereaved single older adults' depression. Data from the National Social Life, Health, and Aging Project (Wave 2;  = 621) were used to test a latent moderated structural equation model that explores the interaction between grief reactions and social support on bereaved single older adults' depression in the US. The findings provide evidence for the stress-buffering model (i. Read More

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http://dx.doi.org/10.1080/07481187.2020.1774943DOI Listing

Patients with hip resurfacing arthroplasty are not physically more active than those with a stemmed total hip.

Acta Orthop 2020 Jun 4:1-5. Epub 2020 Jun 4.

Luxembourg Institute of Health, Human Motion, Orthopedics, Sports Medicine, Digital Methods (HOSD), Luxembourg, Luxembourg.

Background and purpose - Hip resurfacing arthroplasty (HRA) was designed for the highly active patient because of the various theoretical advantages compared with stemmed total hip arthroplasty (THA), but has shown high failure rates. Physical activity (PA) after arthroplasty is frequently determined with the use of questionnaires, which are known for their subjective nature, recall bias, and ceiling effect. These disadvantages are not applicable to physical activity monitoring (AM) using sensors. Read More

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http://dx.doi.org/10.1080/17453674.2020.1771652DOI Listing

Health information needs of 1000 midlife Singaporean women.

Climacteric 2020 Jun 4:1-8. Epub 2020 Jun 4.

Department of Obstetrics & Gynaecology, National University Hospital, National University of Singapore, Singapore, Republic of Singapore.

Due to demographic changes, aging is a health priority. We aimed to identify midlife women's perceived health information needs and the preferred method(s) of information delivery. A questionnaire was offered to women, aged 45-69 years, attending gynecological clinics during April/May 2016, collecting age and ethnicity data. Read More

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http://dx.doi.org/10.1080/13697137.2020.1767570DOI Listing

Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota.

Crit Rev Food Sci Nutr 2020 Jun 4:1-19. Epub 2020 Jun 4.

College of Food Science, Sichuan Agricultural University, Yaan, Sichuan, China.

Naturally occurring compounds polyphenols are secondary metabolites of plants, comprised several categories, namely, flavonoids, phenolic acids, lignans and stilbenes. The biological aging process is driven by a series of interrelated mechanisms, including oxidative stress, inflammation status, and autophagy function, through diverse signaling pathways. Moreover, the crucial role of gut microbiota in regulating aging and health status was widely demonstrated. Read More

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http://dx.doi.org/10.1080/10408398.2020.1773390DOI Listing

Assessing an evidence-based intervention for spouse caregivers of persons with Alzheimer's disease: results of a community implementation of the NYUCI in Israel.

Aging Ment Health 2020 Jun 4:1-8. Epub 2020 Jun 4.

Department of Psychiatry, NYU School of Medicine, NYU Langone Health, New York, NY, USA.

Alzheimer's disease (AD) affects not only the person with the illness, but family caregivers as well. The NYU Caregiver Intervention (NYUCI), a psychosocial intervention which has demonstrated both short and long-term benefits for caregivers, has been used widely in the United States and in Australia and England. The Israeli study was a hybrid between a community implementation study and a randomized controlled trial (RCT) of the NYUCI in a non-English speaking country. Read More

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http://dx.doi.org/10.1080/13607863.2020.1774740DOI Listing

Types of multidimensional vulnerability and well-being among the retired in the U.S.

Aging Ment Health 2020 Jun 4:1-12. Epub 2020 Jun 4.

Department of Social Welfare, Daegu University, Gyeongsan-si, Republic of Korea.

An extensive study investigated the risk factors for low well-being in post-retirement. Most previous studies have taken a unidimensional perspective, focusing on single factors such as financial status, physical health, and mental health. Drawing on the vulnerability framework, we first identify and describe the empirical subgroups of vulnerability among retirees in the United States across four major domains of later life: material, physical, social, and mental vulnerability. Read More

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http://dx.doi.org/10.1080/13607863.2020.1768212DOI Listing

Instruments to evaluate mental well-being in old age: a systematic review.

Aging Ment Health 2020 Jun 4:1-15. Epub 2020 Jun 4.

Department of Psychiatry, Universidad Autónoma de Madrid, Madrid, Spain.

The aim of this study is to identify and appraise existing instruments to evaluate mental well-being in old age. Systematic literature searches in PubMed, PsycINFO, ProQuest Research Library, AgeLine and CINAHL databases were performed. The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guideline was used to assess the measurement properties, reported according to the Preferred Reporting Items for Systematic Reviews and meta-Analysis (PRISMA) statement. Read More

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http://dx.doi.org/10.1080/13607863.2020.1774742DOI Listing

Evaluation of the Diaphragm Muscle Remodeling, Inflammation, Oxidative Stress and Vascularization in Smokers: An Autopsy Study.

Cell Physiol Biochem 2020 Jun;54(4):567-576

Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.

Background/aims: Cigarette smoking is a key factor in systemic inflammation and oxidative stress, and it has also been associated with the loss of muscle strength and an elevated risk of pulmonary diseases. Thus, this study aimed to analyze the effects of cigarette smoking on the diaphragm muscle structure of postmortem samples.

Methods: Immunohistochemical techniques were used for muscle remodeling (metalloproteinases 2 and 9), inflammation (cyclooxygenase-2), oxidative stress (8-hydroxy-2'-deoxyguanosine), and vascularization (vascular endothelial growth factor). Read More

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http://dx.doi.org/10.33594/000000240DOI Listing

Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish.

EMBO Rep 2020 Jun 4:e50287. Epub 2020 Jun 4.

Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.

The oxidative phosphorylation (OXPHOS) system is a dynamic system in which the respiratory complexes coexist with super-assembled quaternary structures called supercomplexes (SCs). The physiological role of SCs is still disputed. Here, we used zebrafish to study the relevance of respiratory SCs. Read More

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http://dx.doi.org/10.15252/embr.202050287DOI Listing

Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models.

Aging Cell 2020 Jun 4. Epub 2020 Jun 4.

Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Microtubule-associated protein Tau, abundant in the central nervous system (CNS), plays crucial roles in microtubule assembly and stabilization. Abnormal Tau phosphorylation and aggregation are a common pathogenic hallmark in Alzheimer's disease (AD). Hyperphosphorylation of Tau could change its conformation and result in self-aggregation, increased oxidative stress, and neuronal death. Read More

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http://dx.doi.org/10.1111/acel.13169DOI Listing