442,937 results match your criteria Ageing & Society[Journal]


Effect of oxidation-induced aging on the adsorption and co-adsorption of tetracycline and Cu onto biochar.

Sci Total Environ 2019 Apr 8;673:522-532. Epub 2019 Apr 8.

Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou, Zhejiang 310058, China.

The bamboo biochars pyrolyzed at 400 °C and 600 °C (BC400 and BC600) were modified by hydrogen peroxide (HO) to obtain the oxidized biochars. Biochar stability and the effect of oxidation treatment on the adsorption and co-adsorption of tetracycline (TC) and Cu onto biochars were investigated. The calculated carbon loss of biochars after oxidation treatment indicated that BC600 presented higher carbon stability than BC400 due to the condensed aromatic structure of biochar. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193160
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.089DOI Listing
April 2019
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Multicomponent exercise and the hallmarks of frailty: Considerations on cognitive impairment and acute hospitalization.

Exp Gerontol 2019 Apr 14. Epub 2019 Apr 14.

Department of Health Sciences, Navarrabiomed, IdiSNA, CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Public University of Navarra, Pamplona, Navarra, Spain. Electronic address:

Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living. On the other hand, physical exercise interventions induce marked improvements in frailty physical hallmarks (e.g. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.007DOI Listing

Relationship between sex steroids and deterioration of bone microarchitecture in older men: the prospective STRAMBO Study.

J Bone Miner Res 2019 Apr 17. Epub 2019 Apr 17.

INSERM UMR 1033, University of Lyon, Hôpital Edouard Herriot, Lyon, France.

In older men, low estrogen levels are associated with poor bone microarchitecture. Data on androgens are discordant. We studied the link between baseline sex steroid levels (total 17β -estradiol [17βE2], total testosterone [tT], calculated bioavailable 17βE2 [bio-17βE2] and apparent free testosterone concentration [AFTC]) and bone microarchitecture deterioration assessed prospectively in a 820 older men followed up for 8 years. Read More

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http://dx.doi.org/10.1002/jbmr.3746DOI Listing

Large cortical bone pores in the tibia are associated with proximal femur strength.

PLoS One 2019 17;14(4):e0215405. Epub 2019 Apr 17.

Berlin-Brandenburg Center for Regenerative Therapies, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Alterations of structure and density of cortical bone are associated with fragility fractures and can be assessed in vivo in humans at the tibia. Bone remodeling deficits in aging women have been recently linked to an increase in size of cortical pores. In this ex vivo study, we characterized the cortical microarchitecture of 19 tibiae from human donors (aged 69 to 94 years) to address, whether this can reflect impairments of the mechanical competence of the proximal femur, i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215405PLOS

Cognitive fatigue and cortical-striatal network in old age.

Aging (Albany NY) 2019 Apr 17. Epub 2019 Apr 17.

School of Nursing, University of Rochester Medical Center, Rochester, NY 14623, USA.

Cognitive fatigue (CF) is among the most common and disturbing aging symptoms, and substantially interferes with activities demanding sustained mental effort. Here we examined the relationship between the cortical-striatal network and CF (assessed by the 18-item visual analogue scale) when a group of cognitively and physically healthy older adults participated in a 30-minute cognitively fatiguing task-related fMRI experiment. We also explored whether CF would interfere with the "Posterior-Anterior Shifting in Aging" (PASA) phenomenon, an aging-associated neural reliance on frontal regions to support cognitive capacity. Read More

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http://dx.doi.org/10.18632/aging.101915DOI Listing

The Concept of Chronic Edema-A Neglected Public Health Issue and an International Response: The LIMPRINT Study.

Lymphat Res Biol 2019 Apr;17(2):121-126

2 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

Lymphedema has always been a neglected global health care problem. A central requirement for the development of any chronic disease is the clear use of public health definitions that can be used internationally to define populations. The term "lymphedema" has historically been defined as either primary, resulting from failure of lymphatic development, or secondary, following damage to the lymphatics (e. Read More

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http://dx.doi.org/10.1089/lrb.2018.0085DOI Listing

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Groningen, University Medical Center Groningen, Pathology and Medical Biology, Groningen, Netherlands.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease. Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2018-0416TR
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http://dx.doi.org/10.1165/rcmb.2018-0416TRDOI Listing
April 2019
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Predicting Early Mild Cognitive Impairment With Free Recall: The Primacy of Primacy.

Arch Clin Neuropsychol 2019 Apr 17. Epub 2019 Apr 17.

School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, UK.

Objectives: Serial position effects have been found to discriminate between normal and pathological aging, and to predict conversion from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD). Different scoring methods have been used to estimate the accuracy of these predictions. In the current study, we investigated delayed primacy as predictor of progression to early MCI over established diagnostic memory methods. Read More

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http://dx.doi.org/10.1093/arclin/acz013DOI Listing

Free Recall of Bound Information Held in Short-Term Memory is Unimpaired by Age and Education.

Arch Clin Neuropsychol 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh Campus, Edinburgh, UK.

Objectives: It has been challenging to identify cognitive markers to differentiate healthy brain aging from neurodegeneration due to Alzheimer's disease (AD) that are not affected by age and education. The Short-Term Memory Binding (STMB) showed not to be affected by age or education when using the change detection paradigm. However, no previous study has tested the effect of age and education using the free recall paradigm of the STMB. Read More

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http://dx.doi.org/10.1093/arclin/acz015DOI Listing

Semantic memory, but not education or intelligence, moderates cognitive aging: a cross-sectional study.

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Objective: Aging studies regularly assume that years of education are a protective factor for baseline cognition. In developing countries with specific sociocultural issues, this relationship may not work as expected, and an unmet need remains for alternative resilience factors. This study aimed to analyze different moderators for the relationship between aging and general cognition that could reflect better protective factors. Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0290DOI Listing

Do drinking problems in the past affect current consumption?

Cad Saude Publica 2019 8;35(4):e00025618. Epub 2019 Apr 8.

Centre for Business and Economics Research, Coimbra, Portugal.

Harmful use of alcohol ranks among the top five risk factors for disease, disability and death worldwide. However, not all individuals who consume alcohol throughout life are addicted and our premise is that addiction implies a chain of consumption that produces harmful effects. The objective of this study was to evaluate whether self-assessed past drinking problems - our measure of harmful alcohol consumption - affect the current alcohol consumption patterns. Read More

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http://dx.doi.org/10.1590/0102-311X00025618DOI Listing

Egocentric and allocentric spatial memory in healthy aging: performance on real-world tasks.

Braz J Med Biol Res 2019 15;52(4):e8041. Epub 2019 Apr 15.

Department of Psychology, University of Oviedo, Oviedo, Spain.

Although normal aging has been related to several cognitive difficulties, other processes have been studied less, such as spatial memory. Our aim was to compare egocentric and allocentric memory in an elderly population using ecological tasks. Twenty-eight cognitively unimpaired participants performed Egocentric and Allocentric Spatial Memory Tasks, as well as Spatial Span from CANTAB, Benton's Judge of Line Orientation test (JoLO), and Montreal Cognitive Assessment test (MoCA). Read More

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http://dx.doi.org/10.1590/1414-431X20198041DOI Listing

Anti-Müllerian Hormone and its Predictive Utility in Assisted Reproductive Technologies Outcomes.

Clin Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut.

Anti-Müllerian hormone (AMH) has become one of the most informative biochemical markers of the ovary and is considered the earliest and most sensitive marker of reproductive aging. The accuracy of AMH in predicting ovarian response to controlled ovarian stimulation has led to AMH-based prognostication counseling and individualization of assisted reproductive technology (ART) stimulation protocols to optimize ovarian response and minimize hyperstimulation risks. Although AMH is considered a good predictor of quantitative ART outcomes, its correlation with qualitative ART outcomes is still controversial. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000436DOI Listing

Dignity Therapy Led by Nurses or Chaplains for Elderly Cancer Palliative Care Outpatients: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc 2019 Apr 17;8(4):e12213. Epub 2019 Apr 17.

Center for Palliative Care Research and Education, College of Nursing, University of Florida, Gainesville, FL, United States.

Background: Our goal is to improve psychosocial and spiritual care outcomes for elderly patients with cancer by optimizing an intervention focused on dignity conservation tasks such as settling relationships, sharing words of love, and preparing a legacy document. These tasks are central needs for elderly patients with cancer. Dignity therapy (DT) has clear feasibility but inconsistent efficacy. Read More

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https://www.researchprotocols.org/2019/4/e12213/
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http://dx.doi.org/10.2196/12213DOI Listing
April 2019
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Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.

Elife 2019 Apr 17;8. Epub 2019 Apr 17.

Department of Neurology, University of Texas Medical Branch, Galveston, United States.

How huntingtin (HTT) triggers neurotoxicity in Huntington's disease (HD) remains unclear. We report that HTT forms a transcription-coupled DNA repair (TCR) complex with RNA polymerase II subunit A (POLR2A), ataxin-3, the DNA repair enzyme polynucleotide-kinase-3'-phosphatase (PNKP), and cyclic AMP-response element-binding (CREB) protein (CBP). This complex senses and facilitates DNA damage repair during transcriptional elongation, but its functional integrity is impaired by mutant HTT. Read More

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https://elifesciences.org/articles/42988
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http://dx.doi.org/10.7554/eLife.42988DOI Listing
April 2019
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Identification of CTX-M-15 and CTX-M-27 in Antibiotic-Resistant Gram-Negative Bacteria Isolated from Three Rivers Running in Central Italy.

Microb Drug Resist 2019 Apr 17. Epub 2019 Apr 17.

2 Department of Medical, Oral and Biotechnological Sciences, and Center of Excellence on Aging and Translational Medicine (CeSI-MeT), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.

The main goal of this study was to identify Gram-negative bacteria resistant to antibiotics, in particular β-lactams, in stream waters and effluents from urban wastewater treatment plants draining into Fino, Tavo, and Saline rivers of the Abruzzo region, Italy. Eight sampling sites were selected because they were the most contaminated by coliforms during previous sampling campaign. One sample for each site was collected for the detection of total and fecal coliforms, and species by Colilert-18 and Enterolert-E Quanti-Tray/2000. Read More

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http://dx.doi.org/10.1089/mdr.2019.0016DOI Listing

Better therapeutic potential of bone marrow-derived mesenchymal stem cells compared with chorionic villi-derived mesenchymal stem cells in airway injury model.

Regen Med 2019 Mar 27;14(3):165-177. Epub 2019 Feb 27.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

To determine the efficiency of mesenchymal stem cells (MSCs) of different sources on airway epithelial cells regeneration and track where and to what extent transplanted MSCs home to injured tissues. We performed DiO-labeled human bone marrow-derived MSCs (hBMSCs) or human chorionic villi-derived MSCs transplantation studies using naphthalene-induced airway injury animal models. Compared with human chorionic villi-derived MSCs, hBMSCs facilitated airway epithelium regeneration faster and better from day 5 after transplantation; moreover, more transplanted hBMSCs distributed in injured lung tissues at the early stage of postinjury, which was mediated by C-X-C motif chemokine ligand 12. Read More

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http://dx.doi.org/10.2217/rme-2018-0152DOI Listing

Telehealth Intervention Programs for Seniors: An Observational Study of a Community-Embedded Health Monitoring Initiative.

Telemed J E Health 2019 Apr 17. Epub 2019 Apr 17.

1 Department of Telemedicine and Virtual Rehabilitation, Burke Medical Research Institute, White Plains, New York.

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http://dx.doi.org/10.1089/tmj.2018.0248DOI Listing

Affective theory of mind in human aging: is there any relation with executive functioning?

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 Apr 17:1-13. Epub 2019 Apr 17.

c Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit , Istanbul University , Istanbul , Turkey.

Theory of Mind (ToM) refers to the ability to make inferences on other's mental or emotional states. Although there is evidence suggesting that impaired executive functions due to aging could have a negative impact on cognitive ToM, there is still controversy about the effect of age and age-related executive dysfunctions on affective ToM. To investigate affective ToM in healthy aging and its relationship with executive functions, we examined Reading Mind in the Eyes Test (RMET) performance and executive functions among young and older adults. Read More

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http://dx.doi.org/10.1080/13825585.2019.1602706DOI Listing

Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: The Multi-Ethnic Study of Atherosclerosis (MESA).

Sleep 2019 Apr 17. Epub 2019 Apr 17.

Departments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School.

Study Objectives: Sleep disturbances and sleep apnea are associated with increased vulnerability to age-related disease, altering molecular pathways affecting biological aging. Telomere length captures one component of biological aging. We evaluated whether objectively assessed sleep and sleep apnea relate to leukocyte telomere length (LTL) in the Multi-Ethnic Study of Atherosclerosis (MESA). Read More

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https://academic.oup.com/sleep/advance-article/doi/10.1093/s
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http://dx.doi.org/10.1093/sleep/zsz089DOI Listing
April 2019
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Hygiene and Public Health courses in Biology curricula: the Italian scenario and the best examples from all over the world.

Authors:
A Agodi

Ann Ig 2019 Mar-Apr;31(2 Supple 1):90-95

Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Catania, Italy.

Different longstanding and emerging challenges for public health have been identified including population ageing, migration, infectious and non-communicable diseases, the environment and climatic changes, increasing risks of misinformation and chronic underinvestment. The multi- and inter-disciplinary public health approach - including biology, epidemiology, biostatistics, anthropology and public policy - raises the need to train experienced professionals in different fields. The education on these matters is fundamental to ensure the human well-being. Read More

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http://dx.doi.org/10.7416/ai.2019.2281DOI Listing

The Role of Participants in a Medical Information Commons.

J Law Med Ethics 2019 Mar;47(1):51-61

Mary A. Majumder, J.D., Ph.D., is an Associate Professor of Medicine at the Center for Medical Ethics and Health Policy, Baylor College of Medicine. Juli M. Bollinger, M.S., is a Research Associate in the Center for Medical Ethics and Health Policy at the Baylor College of Medicine and a Research Associate and Associate Faculty at the Berman Institute of Bioethics at Johns Hopkins University. Angela G. Villanueva, M.P.H., is a Research Associate at the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Patricia A. Deverka, M.D., M.S., M.B.E., is Director, Value Evidence and Outcomes at Geisinger National Precision Health, where she focuses on demonstrating the value of genomic sequencing for health systems and policymakers. Barbara A. Koenig, Ph.D., is Professor of Bioethics and Medical Anthropology, based at the Institute for Health & Aging, University of California, San Francisco. She serves as Director of the UCSF Program in Bioethics. Previously, Prof. Koenig was the founding executive director of the Center for Biomedical Ethics at Stanford University; she created and led the Bioethics Research Program at the Mayo Clinic in Rochester, Minn.

Meaningful participant engagement has been identified as a key contributor to the success of efforts to share data via a "Medical Information Commons" (MIC). We present findings from expert stakeholder interviews aimed at understanding barriers to engagement and the appropriate role of MIC participants. Although most interviewees supported engagement, they distinguished between individual versus collective forms. Read More

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http://dx.doi.org/10.1177/1073110519840484DOI Listing
March 2019
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Hopeful and Concerned: Public Input on Building a Trustworthy Medical Information Commons.

J Law Med Ethics 2019 Mar;47(1):70-87

Patricia A. Deverka, M.D., M.S., M.B.E., is Director, Value Evidence and Outcomes at Geisinger National Precision Health, where she focuses on demonstrating the value of genomic sequencing for health systems and policymakers. Dierdre Gilmore, M.A., is a Senior Researcher at the American Institutes for Research. Gilmore earned a MA in Medical Anthropology at the University of London. Jennifer Richmond, M.S.P.H., is a Research Associate at the American Institutes for Research and a doctoral student in the Department of Health Behavior at the University of North Carolina at Chapel Hill (UNC-CH) Gillings School of Global Public Health. Zachary Smith is a Research Assistant at the American Institutes for Research. Rikki Mangrum, M.L.S., is a Senior Research Scientist at the American Institutes for Research. Barbara A. Koenig, Ph.D., is Professor of Bioethics and Medical Anthropology, based at the Institute for Health & Aging, University of California, San Francisco. She serves as Director of the UCSF Program in Bioethics. Robert Cook-Deegan, M.D., is a Professor in the School for the Future of Innovation in Society at Arizona State University. He is a physician and molecular biologist who turned to policy and then entered academe through Georgetown, Stanford, and Duke Universities before joining ASU. Angela G. Villanueva, M.P.H., is a Research Associate at the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Mary A. Majumder, J.D., Ph.D., is an Associate Professor of Medicine at the Center for Medical Ethics and Health Policy, Baylor College of Medicine. Amy L. McGuire, J.D., Ph.D., is the Leon Jaworski Professor of Biomedical Ethics and Director of the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Dr. McGuire serves on the program committee for the Greenwall Foundation Faculty Scholars Program in Bioethics and is immediate past president of the Association of Bioethics Program Directors.

A medical information commons (MIC) is a networked data environment utilized for research and clinical applications. At three deliberations across the U.S. Read More

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http://dx.doi.org/10.1177/1073110519840486DOI Listing
March 2019
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Characterizing the Biomedical Data-Sharing Landscape.

J Law Med Ethics 2019 Mar;47(1):21-30

Angela G. Villanueva, M.P.H., is a Research Associate at the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Robert Cook-Deegan, M.D., is a Professor in the School for the Future of Innovation in Society at Arizona State University. Barbara A. Koenig, Ph.D., is Professor of Bioethics and Medical Anthropology, based at the Institute for Health & Aging, University of California, San Francisco. Patricia A. Deverka, M.D., M.S., M.B.E., is Director, Value Evidence and Outcomes at Geisinger National Precision Health, where she focuses on demonstrating the value of genomic sequencing for health systems and policy-makers.Erika Versalovic is a Ph.D. student in the philosophy department at the University of Washington and a neuroethics fellow with the Center for Neurotechnology in Seattle, WA. Amy L. McGuire, J.D., Ph.D., is the Leon Jaworski Professor of Biomedical Ethics and Director of the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Mary A. Majumder, J.D., Ph.D., is an Associate Professor of Medicine at the Center for Medical Ethics and Health Policy, Baylor College of Medicine.

Advances in technologies and biomedical informatics have expanded capacity to generate and share biomedical data. With a lens on genomic data, we present a typology characterizing the data-sharing landscape in biomedical research to advance understanding of the key stakeholders and existing data-sharing practices. The typology highlights the diversity of data-sharing efforts and facilitators and reveals how novel data-sharing efforts are challenging existing norms regarding the role of individuals whom the data describe. Read More

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http://dx.doi.org/10.1177/1073110519840481DOI Listing

Importance of Participant-Centricity and Trust for a Sustainable Medical Information Commons.

J Law Med Ethics 2019 Mar;47(1):12-20

Amy L. McGuire, J.D., Ph.D., is the Leon Jaworski Professor of Biomedical Ethics and Director of the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Dr. McGuire serves on the program committee for the Greenwall Foundation Faculty Scholars Program in Bioethics and is immediate past president of the Association of Bioethics Program Directors. Mary A. Majumder, J.D., Ph.D., is an Associate Professor of Medicine at the Center for Medical Ethics and Health Policy, Baylor College of Medicine. Angela G. Villanueva, M.P.H., is a Research Associate at the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Jessica Bardill, Ph.D., is an Assistant Professor of Indigenous Canadian Literatures and Cultures at Concordia University in Montreal, Quebec. Juli M. Bollinger, M.S., is a Research Associate in the Center for Medical Ethics and Health Policy at the Baylor College of Medicine and a Research Associate and Associate Faculty at the Berman Institute of Bioethics at Johns Hopkins University. Eric Boerwinkle, Ph.D., is the Dean of the University of Texas Health Science Center at Houston, School of Public Health and the Associate Director, Human Genome Sequencing Center at Baylor College of Medicine. Tania Bubela, Ph.D., J.D., is the Dean of the Faculty of Health Sciences at Simon Fraser University and a Fellow of the Canadian Academy of Health Sciences. Patricia Deverka, M.D., M.S., M.B.E., is Director, Value Evidence and Outcomes at Geisinger National Precision Health, where she focuses Outcomes at Geisinger National Precision Health, where she focuses systems and policymakers. Barbara Evans, MS, Ph.D., J.D., LL.M., is the Mary Ann and Lawrence E. Faust Professor of Law and Director of the Center for Biotechnology & Law at the University of Houston Law Center and holds a joint appointment as Professor of Electrical and Computer Engineering at the UH Cullen College of Engineering. Nanibaa' A. Garrison, Ph.D. (Navajo), is an Assistant Professor at the Treuman Katz Center for Pediatric Bioethics at Seattle Children's Hospital and Research Institute and at the Department of Pediatrics at the University of Washington School of Medicine. David Glazer is an engineering director at Verily Life Sciences, where he helps life science organizations use cloud computing to accelerate and scale their work with big data. Melissa M. Goldstein, J.D., is an Associate Professor in the Department of Health Policy and Management at the Milken Institute School of Public Health at the George Washington University. Henry T. Greely, J.D., is the Deane F. and Kate Edelman Johnson Professor of Law and a professor (by courtesy) of Genetics at Stanford University, where he directs the Center for Law and the Biosciences. He is President of the International Neuroethics Society, co-chair of the Neuroethics Work Group of the NIH BRAIN Initiative, and a member of the National Academies' Committee on Science, Technology, and Law. Scott D. Kahn, Ph.D., is the Chief Information Officer at LunaDNA where he is responsible for all informatics and data science strategy. Bartha M. Knoppers, Ph.D., (Comparative Medical Law), is a Full Professor, Canada Research Chair in Law and Medicine and Director of the Centre of Genomics and Policy of the Faculty of Medicine at McGill University. Barbara A. Koenig, Ph.D., is Professor of Bioethics and Medical Anthropology, based at the Institute for Health & Aging, University of California, San Francisco. She also serve as Director of the UCSF Program in Bioethics. J. Mark Lambright, M.B.A., is the Chairman, Trident Advisors, LLC - CEO (Interim), Private Access, Inc. Mark Lambright has been a senior executive of a number of healthcare and technology companies ranging in size from startup to multi-billion in revenue. John Mattison, M.D., is Assistant Medical Director, KP, SCAL, Chief Health Information Officer. Founder of CDA/CCD (XML standard for healthcare interoperability). Co-Editor of Healthcare Information Technology (2017 McGraw Hill). Christopher J. O'Donnell, M.D., M.P.H., is Chief, Cardiology Section and Director, Center for Population Genomics, of the Boston VA Healthcare System and co-Principal Investigator (Chief Scientist) of the national VA Million Veteran Program; and is VA Contact Principal Investigator of the NIH All of Us Research Program. He is also a faculty member of the Department of Medicine, Brigham and Women's Hospital and Associate Professor of Medicine, Harvard Medical School. Arti K. Rai, J.D., is the Elvin R. Latty Professor of Law and co-Director of the Center for Innovation Policy at Duke Law. Laura L. Rodriguez, Ph.D., is the Director of the Division of Policy, Communications, and Education at the National Human Genome Research Institute. Tania Simoncelli, M.S., is the Director of Science Policy at the Chan Zuckerberg Initiative. Formerly Executive Director, Count Me In at the Broad Institute, Assistant Director of Forensic Science and Biomedical Innovation, White House Office of Science & Technology Policy, and Science Advisor to the American Civil Liberties Union. Sharon F. Terry, M.A., is the president and CEO of Genetic Alliance. Adrian Thorogood, B.C.L./LL.B., is a lawyer and Academic Associate at the Centre of Genomics and Policy at McGill University in Montreal, Canada. He manages the Regulatory and Ethics Work Stream of the Global Alliance for Genomics and Health. Michael S. Watson, M.S., Ph.D., is the Executive Director, American College of Medical Genetics and Genomics and ACMG Foundation for Genetic and Genomic Medicine and an Adjunct Professor of Pediatrics at Washington University School of Medicine. John T. Wilbanks is the Chief Commons Officer at Sage Bionetworks, and co-PI on awards for AllofUs Research Program, ELSI Issues in Unregulated Mobile Research, CTSA Center for Data To Health. Robert Cook-Deegan, M.D., is a Professor in the School for the Future of Innovation in Society at Arizona State University.

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons (MIC). Read More

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http://dx.doi.org/10.1177/1073110519840480DOI Listing

Aging, Disease, and Therapeutic Apheresis.

Authors:
Paul S Malchesky

Ther Apher Dial 2018 Aug;22(4):312-316

International Center for Artificial Organs & Transplantation, Painesville, OH, USA.

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http://dx.doi.org/10.1111/1744-9987.12706DOI Listing

Is unwilling volunteering protective for functional decline? The interactive effects of volunteer willingness and engagement on health in a 3-year longitudinal study of Japanese older adults.

Geriatr Gerontol Int 2019 Apr 16. Epub 2019 Apr 16.

Institute for Gerontology, J. F. Oberlin University, Tokyo, Japan.

Aim: The present study explored the interactive effects of willingness to volunteer and actual volunteer engagement on the maintenance of functional health among older Japanese adults, using data from a 3-year longitudinal study.

Methods: We used data from the 3-year longitudinal Tokyo Metropolitan Institute of Gerontology Longitudinal Interdisciplinary Study on Aging (1997). We examined 676 older adults aged >65 years from the rural Nangai District who were independent in their basic activities of daily living (BADL). Read More

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http://dx.doi.org/10.1111/ggi.13667DOI Listing

Early outcomes after implementation of treat all in Rwanda: an interrupted time series study.

J Int AIDS Soc 2019 Apr;22(4):e25279

Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.

Introduction: Nearly all countries in sub-Saharan Africa have adopted policies to provide antiretroviral therapy (ART) to all persons living with HIV (Treat All), though HIV care outcomes of these programmes are not well-described. We estimated changes in ART initiation and retention in care following Treat All implementation in Rwanda in July 2016.

Methods: We conducted an interrupted time series analysis of adults enrolling in HIV care at ten Rwandan health centres from July 2014 to September 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jia2.25279
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http://dx.doi.org/10.1002/jia2.25279DOI Listing
April 2019
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Mandibular implant-supported overdentures in (frail) elderly: A prospective study with 20-year follow-up.

Clin Implant Dent Relat Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Purpose: To prospectively assess long-term (20 year) clinical, radiographic, and patient-reported outcomes of an elderly population provided with mandibular implant-supported overdentures.

Materials And Methods: A total of 53 elderly (aged ≥60 years at the time of treatment) were provided with two endosseous implants supporting a mandibular overdenture and a conventional maxillary denture. Outcome parameters-including implant loss, plaque index, gingival index, bleeding index, presence of calculus, probing depth, and satisfaction with implant-supported overdenture-were scored 1, 5, 10, and 20 years after prosthetic treatment. Read More

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http://dx.doi.org/10.1111/cid.12772DOI Listing

Language paradigms when behaviour changes with dementia: #BanBPSD.

Int J Geriatr Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Dementia Centre for Research Collaboration, School of Psychiatry, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1002/gps.5122DOI Listing
April 2019
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Clinical and pathological outcomes of induction chemotherapy before neoadjuvant radiotherapy in locally-advanced rectal cancer.

J Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Division of Colorectal Surgery, Michigan Medicine, Ann Arbor, Michigan.

Background And Objectives: In North America, preoperative combination chemoradiation is the most commonly recommended and utilized approach to locally advanced rectal cancer. There is increasing interest in the use of induction chemotherapy (IC) before radiation and surgery in locally advanced rectal cancer. How widely IC is being used and whether it improves pathologic and oncologic outcomes is unknown. Read More

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http://dx.doi.org/10.1002/jso.25474DOI Listing

The association between hand grip strength and rehabilitation outcome in post-acute hip fractured patients.

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

Beit Rivka Geriatric Rehabilitation Center, 4 Hachamisha St, 49245, Petach Tikva, Israel.

Purpose: Various factors have been shown to affect the rehabilitation outcome of hip fractured patients. Considering the decrease in muscle mass with aging and its impact on mobility, we hypothesized that a relationship exists between hand grip strength and rehabilitation outcome.

Methods: We retrospectively studied 373 post-hip fracture patients, admitted for rehabilitation. Read More

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http://dx.doi.org/10.1007/s40520-019-01200-yDOI Listing

Relationship between comorbidities and treatment decision-making in elderly hip fracture patients.

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Geriatrics, West China Hospital, Sichuan University, NO. 37 GuoXue Road, Chengdu, 610041, Sichuan, China.

Background: Elderly patients are at a higher risk for hip fracture. Moreover, hospitalized elderly patients with hip fracture are vulnerable to adverse outcomes including higher mortality rate and long-term disability. Treatment decision-making with respect to surgical procedure and perioperative management of these patients is typically challenging owing to the presence of multiple comorbid conditions. Read More

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http://dx.doi.org/10.1007/s40520-019-01134-5DOI Listing

Effects of oxycodone applied for patient-controlled analgesia on postoperative cognitive function in elderly patients undergoing total hip arthroplasty: a randomized controlled clinical trial.

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology, The Third People's Hospital of Chengdu, Southwest Jiao Tong University, No. 82 Qinglong Street, Chengdu, 610031, Sichuan, China.

Background: Postoperative cognitive dysfunction (POCD) is a common complication after orthopedic surgery, which is not conducive to the prognosis of the elderly.

Aims: We performed this study to investigate the effects of oxycodone applied for patient-controlled intravenous analgesia (PCIA) on postoperative cognitive function in elderly patients after total hip arthroplasty (THA).

Methods: Ninety-nine participants were enrolled and allocated into two groups: oxycodone group (group O) and sufentanil group (group S). Read More

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http://dx.doi.org/10.1007/s40520-019-01202-wDOI Listing
April 2019
1.138 Impact Factor

Practical guidance for engaging patients in health research, treatment guidelines and regulatory processes: results of an expert group meeting organized by the World Health Organization (WHO) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium.

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients' needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1007/s40520-019-01193-8DOI Listing

Late presentation of Takayasu arteritis in geriatric patients.

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Internal Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s40520-019-01201-xDOI Listing

Visual evoked and event-related brain potentials in HIV-infected adults: a longitudinal study over 2.5 years.

Doc Ophthalmol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathological Physiology, Charles University - Faculty of Medicine in Hradec Kralove, Simkova 870, 500 03, Hradec Kralove, Czech Republic.

Purpose: The aim of this neurophysiological study was to monitor changes in the visual and cognitive function of HIV-infected patients treated with combination antiretroviral therapy.

Methods: Eleven adult Czech HIV+ patients, with a mean age of 35 years and CD4 cell count ≥ 230 × 10 cells/L of blood at the time of enrollment, underwent four to six examinations over the course of 2.5 years to evaluate pattern-reversal and motion-onset visual evoked potentials (P-VEPs and M-VEPs), visually driven oddball event-related potentials (ERPs) and Montreal Cognitive Assessments. Read More

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http://dx.doi.org/10.1007/s10633-019-09697-4DOI Listing

Biological Hallmarks of Cancer in Alzheimer's Disease.

Mol Neurobiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.

Although Alzheimer's disease (AD) is an international health research priority for our aging population, little therapeutic progress has been made. This lack of progress may be partially attributable to disease heterogeneity. Previous studies have identified an inverse association of cancer and AD, suggesting that cancer history may be one source of AD heterogeneity. Read More

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http://dx.doi.org/10.1007/s12035-019-1591-5DOI Listing

Incidence and excess mortality of hip fractures in a predominantly Caucasian population in the South of Brazil.

Arch Osteoporos 2019 Apr 16;14(1):47. Epub 2019 Apr 16.

Endocrine Center of UFPR, Universidade Federal do Paraná, Curitiba, Brazil.

Introduction: Osteoporosis is a very common disease, and data on its epidemiology is important for health care strategy implementation. Brazil is a developing country; its population is aging, leading to an expected increase in hip fractures and their undesirable consequences.

Objective: Assess the incidence of osteoporotic hip fractures and subsequent mortality in Southern Brazil as part of a large epidemiological study aiming to reinforce the data for FRAX Brazil. Read More

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http://dx.doi.org/10.1007/s11657-019-0597-yDOI Listing

WHISTLE: a high-accuracy map of the human N6-methyladenosine (m6A) epitranscriptome predicted using a machine learning approach.

Nucleic Acids Res 2019 Apr;47(7):e41

Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China.

N 6-methyladenosine (m6A) is the most prevalent post-transcriptional modification in eukaryotes, and plays a pivotal role in various biological processes, such as splicing, RNA degradation and RNA-protein interaction. We report here a prediction framework WHISTLE for transcriptome-wide m6A RNA-methylation site prediction. When tested on six independent datasets, our approach, which integrated 35 additional genomic features besides the conventional sequence features, achieved a major improvement in the accuracy of m6A site prediction (average AUC: 0. Read More

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http://dx.doi.org/10.1093/nar/gkz074DOI Listing

Two Approaches to Classifying and Quantifying Physical Resilience in Longitudinal Data.

J Gerontol A Biol Sci Med Sci 2019 Apr 17. Epub 2019 Apr 17.

Duke University, Durham, North Carolina, United States.

Background: Approaches for quantifying physical resilience in older adults have not been described.

Methods: We apply 2 conceptual approaches to defining physical resilience to existing longitudinal datasets in which outcomes are measured after an acute physical stressor. A "recovery phenotype" approach uses statistical methods to describe how quickly and completely a patient recovers. Read More

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http://dx.doi.org/10.1093/gerona/glz097DOI Listing

Resilience strategies against working pressures in midwives: A qualitative study.

J Educ Health Promot 2019 15;8:33. Epub 2019 Feb 15.

Department of Nursing, School of Nursing and Midwifery, Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Introduction: The lack of experienced midwifery in obstetrics and gynecology centers would have harmful consequences. Resilience could increase midwives' endurance while caring for women and neonates in the maternity hospitals. Research on resilience of midwives is rare. Read More

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http://dx.doi.org/10.4103/jehp.jehp_241_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432840PMC
February 2019

Induction of Apoptosis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells.

J Cancer Prev 2019 Mar 30;24(1):11-19. Epub 2019 Mar 30.

Department of Biochemistry, Dong-Eui University College of Korean Medicine, Busan, Korea.

Background: The roots of Georgi (Labiatae) have been widely used in traditional medicine for treatment of various diseases. In this study, we investigated the effects of ethanol extracts of roots (EESB) on the growth ofn human leukemia U937 cells.

Methods: The effect of EESB on cell viability was measured by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. Read More

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http://dx.doi.org/10.15430/JCP.2019.24.1.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453591PMC

The impact of multisite pain on functional outcomes in older adults: biopsychosocial considerations.

J Pain Res 2019 29;12:1115-1125. Epub 2019 Mar 29.

Department of Aging & Geriatric Research, Institute on Aging, Pain Research & Intervention Center of Excellence, Center for Cognitive Aging & Memory, University of Florida, Gainesville, FL 32610, USA,

Multisite pain, or pain that occurs simultaneously at >1 anatomical site, is more prevalent than single-site pain. While multisite pain affects over half of older adults, it remains an understudied pain entity that may have important functional implications in an aging population. Greater understanding of this complex pain entity from a biopsychosocial perspective is critical for optimizing clinical and functional outcomes in older adults with pain. Read More

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http://dx.doi.org/10.2147/JPR.S192755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445225PMC

Effect of genetic polymorphisms on Alzheimer's disease treatment outcomes: an update.

Clin Interv Aging 2019 29;14:631-642. Epub 2019 Mar 29.

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia,

Genetic variations in individuals may cause differences in the response to cholinesterase inhibitor drugs used in the treatment of Alzheimer's disease (AD). Through this review, we aimed to understand the potential relationship between genetic polymorphisms and treatment response in AD. We conducted a systematic review of the studies published from 2006 to 2018 that assessed the relationship between genetic polymorphisms and the pharmacotherapeutic outcomes of patients with AD. Read More

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http://dx.doi.org/10.2147/CIA.S200109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445219PMC
March 2019
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Melatonin benefits to the growth of human annulus fibrosus cells through inhibiting miR-106a-5p/ATG7 signaling pathway.

Clin Interv Aging 2019 28;14:621-630. Epub 2019 Mar 28.

Department of Orthopedics, Peking University Third Hospital, Beijing 100191, People's Republic of China,

Background: Disc degeneration (DD) is one of the common diseases worldwide, which deeply influences normal life and leads to excruciating pain. However, an effective treatment for DD is still not identified.

Method: The present study systemically examined the effect of melatonin on annulus fibrosus (AF) cells of patients with DD. Read More

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http://dx.doi.org/10.2147/CIA.S193765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445191PMC

Comprehensive comparison of antioxidant properties of tinctures.

Sci Rep 2019 Apr 16;9(1):6148. Epub 2019 Apr 16.

Department of Materials Chemistry and Chemical Technology, Institute of Chemistry, The University of Silesia, 9 Szkolna Street, 40-006, Katowice, Poland.

Homemade tinctures, traditional Polish alcoholic beverages called "nalewkas" (similar to alcohol herbal tinctures), which antioxidant capacity have never been studied before, were characterized by electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR) and ultraviolet visible (UV-vis) spectroscopy. The antioxidant properties of nalewkas made according to homemade recipes were compared to commercially produced nalewkas. The impact of aging on antioxidant properties of nalewkas was investigated. Read More

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http://dx.doi.org/10.1038/s41598-019-42656-2DOI Listing

Transcriptomic analysis reveals differences in the regulation of amino acid metabolism in asexual and sexual planarians.

Sci Rep 2019 Apr 16;9(1):6132. Epub 2019 Apr 16.

Department of Biology, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori, 036-8561, Japan.

Many flatworms can alternate between asexual and sexual reproduction. This is a powerful reproductive strategy enabling them to benefit from the features of the two reproductive modes, namely, rapid multiplication and genetic shuffling. The two reproductive modes are enabled by the presence of pluripotent adult stem cells (neoblasts), by generating any type of tissue in the asexual mode, and producing and maintaining germ cells in the sexual mode. Read More

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http://dx.doi.org/10.1038/s41598-019-42025-zDOI Listing

Multi-platform discovery of haplotype-resolved structural variation in human genomes.

Nat Commun 2019 Apr 16;10(1):1784. Epub 2019 Apr 16.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.

The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies of human genetic diversity and disease association. Here, we apply a suite of long-read, short-read, strand-specific sequencing technologies, optical mapping, and variant discovery algorithms to comprehensively analyze three trios to define the full spectrum of human genetic variation in a haplotype-resolved manner. We identify 818,054 indel variants (<50 bp) and 27,622 SVs (≥50 bp) per genome. Read More

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http://www.nature.com/articles/s41467-018-08148-z
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http://dx.doi.org/10.1038/s41467-018-08148-zDOI Listing
April 2019
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Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan.

Proc Natl Acad Sci U S A 2019 Apr 16. Epub 2019 Apr 16.

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461;

Accumulation of mutations in somatic cells has been implicated as a cause of aging since the 1950s. However, attempts to establish a causal relationship between somatic mutations and aging have been constrained by the lack of methods to directly identify mutational events in primary human tissues. Here we provide genome-wide mutation frequencies and spectra of human B lymphocytes from healthy individuals across the entire human lifespan using a highly accurate single-cell whole-genome sequencing method. Read More

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http://dx.doi.org/10.1073/pnas.1902510116DOI Listing