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    Identification of older adults with frailty in the Emergency Department using a frailty index: results from a multinational study.
    Age Ageing 2017 Nov 20:1-7. Epub 2017 Nov 20.
    Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Canada.
    Objective: frailty is a central concept in geriatric medicine, yet its utility in the Emergency Department (ED) is not well understood nor well utilised. Our objectives were to develop an ED frailty index (FI-ED), using the Rockwood cumulative deficits model and to evaluate its association with adverse outcomes.

    Method: this was a large multinational prospective cohort study using data from the interRAI Multinational Emergency Department Study. Read More

    Trajectories of frailty among Chinese older people in Hong Kong between 2001 and 2012: an age-period-cohort analysis.
    Age Ageing 2017 Nov 17:1-7. Epub 2017 Nov 17.
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
    Background: there is little evidence to suggest that older people today are living in better health than their predecessors did at the same age. Only a few studies have evaluated whether there are birth cohort effects on frailty, an indicator of health in older people, encompassing physical, functional and mental health dimensions.

    Objectives: this study examined longitudinal trajectories of frailty among Chinese older people in Hong Kong. Read More

    Tumour boards in geriatric oncology.
    Age Ageing 2017 Nov 14:1-3. Epub 2017 Nov 14.
    School of Medicine, University of Nottingham, Nottingham, UK.
    Multidisciplinary tumour board is an integral part of cancer treatment planning. Although no definite survival benefits have yet been shown by mostly observational studies, other benefits of multidisciplinary tumour board have been identified. Traditionally the multidisciplinary tumour board involves participation of treating clinicians-medical, radiation and surgical oncologists. Read More

    Supported Discharge Teams for older people in hospital acute care hospital: a randomised controlled trial.
    Age Ageing 2017 Nov 14:1-6. Epub 2017 Nov 14.
    Department of General Practice and Primary Care, The University of Auckland, Auckland, New Zealand.
    Background: Supported Discharge Teams aim to help with the transition from hospital to home, whilst reducing hospital length-of-stay. Despite their obvious attraction, the evidence remains mixed, ranging from strong support for disease-specific interventions to less favourable results for generic services.

    Objective: To determine whether older people referred to a Supported Discharge Team have: (i) reduced length-of-stay in hospital; (ii) reduced risk of hospital readmission; and (iii) reduced healthcare costs. Read More

    Effects of multidomain lifestyle intervention, omega-3 supplementation or their combination on physical activity levels in older adults: secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) randomised controlled trial.
    Age Ageing 2017 Nov 10:1-8. Epub 2017 Nov 10.
    Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.
    Background/objectives: to investigate the effects of a 3-year multidomain lifestyle intervention, omega-3 supplementation or both on physical activity (PA) in older adults with subjective memory complaints.

    Design/settings/subjects: the Multidomain Alzheimer Preventive Trial was a 3-year randomised controlled trial that enroled 1,680 community-dwelling adults aged 70 years or over, with subjective memory complaints. Participants were randomised to omega-3 supplementation (total daily dose of 800 mg docosahexanoic acid and up to 225 mg eicosapentanoic acid), multidomain intervention (nutritional and exercise counselling and cognitive training), omega-3 plus multidomain intervention or placebo with usual care. Read More

    Increased diastolic blood pressure is associated with MRI biomarkers of dementia-related brain pathology in normative ageing.
    Age Ageing 2017 Jul 4:1-6. Epub 2017 Jul 4.
    Aberdeen Biomedical Imaging Centre, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.
    Background: hypertension is a risk for brain ageing, but the mechanisms underlying this effect remain unclear. Magnetic resonance imaging (MRI) detected biomarkers of brain ageing include white matter hyperintensities (WMHs), a marker of cerebrovascular disease, and hippocampal volume, a marker of Alzheimer's disease pathology.

    Objective: to examine relationships between blood pressure (BP) components and brain pathology in older adults. Read More

    Childlessness and vulnerability of older people in China.
    Age Ageing 2017 Oct 31:1-6. Epub 2017 Oct 31.
    Centre for Research on Ageing and ESRC Centre for Population Change, School of Social Sciences, Faculty of Social, Human and Mathematical Sciences, University of Southampton, Southampton, UK.
    Background: the number of childless older people is increasing in China, but relatively little is known about the role of childlessness in health outcomes. This study investigates the relationship between childlessness and three health outcomes: difficulty with Instrumental Activities of Daily Living (IADLs), self-rated health and depression.

    Methods: this study includes 13,171 individuals aged 50 and above from national survey data of the second wave of the China Family Panel Study (2012). Read More

    Inception and deprescribing of statins in people aged over 80 years: cohort study.
    Age Ageing 2017 Nov;46(6):1001-1005
    King's College London, Department of Primary Care and Public Health Sciences, London, UK.
    Objective: statin use over the age of 80 years is weakly evidence-based. This study aimed to estimate rates of statin inception and deprescribing by frailty level in people aged 80 years or older.

    Methods: a cohort of 212,566 participants aged ≥80 years was sampled from the UK Clinical Practice Research Datalink. Read More

    Subjective cognitive concerns are associated with objective memory performance in Caucasian but not African-American persons.
    Age Ageing 2017 Nov;46(6):988-993
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114-2621, USA.
    Objective: subjective cognitive concerns (SCC) have been proposed as a means of identifying individuals at risk for Alzheimer's disease (AD). However, the utility of SCCs has not been well-explored for African-Americans, who are twice as likely to develop AD dementia as Caucasians. We investigated whether race affects the association between SCCs and objective memory performance. Read More

    Alcohol consumption in midlife and old age and risk of frailty: Alcohol paradox in a 30-year follow-up study.
    Age Ageing 2017 Oct 27:1-7. Epub 2017 Oct 27.
    University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    Background: alcohol consumption has many harmful health effects, but also benefits of moderate consumption on frailty have been reported. We examined this relationship longitudinally from midlife to old age.

    Methods: data of reported alcohol consumption in midlife (year 1974) and in old age (years 2000 and 2003) were available of a socioeconomically homogenous sample of 2360 men (born 1919-34, the Helsinki Businessmen Study). Read More

    Z-drugs and risk for falls and fractures in older adults-a systematic review and meta-analysis.
    Age Ageing 2017 Oct 25:1-8. Epub 2017 Oct 25.
    Division of Clinical Pharmacy, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.
    Objective: zolpidem, zopiclone, eszopiclone and zaleplon, also known as 'Z-drugs', are commonly used as alternatives to benzodiazepines (BZDs) to treat insomnia. Z-drugs are often perceived as safer than BZDs. We conducted a systematic review and meta-analysis evaluating the association between Z-drugs and fracutres, falls and injuries. Read More

    Frailty index as a predictor of mortality: a systematic review and meta-analysis.
    Age Ageing 2017 Oct 13:1-8. Epub 2017 Oct 13.
    Department of Primary Care and Population Health, University College London, Rowland Hill Street, London NW3 2PF, United Kingdom of Great Britain and Northern Ireland.
    Background: two popular operational definitions of frailty, the frailty phenotype and Frailty index (FI), are based on different theories. Although FI was shown to be superior in predicting mortality to the frailty phenotype, no meta-analysis on mortality risk according to FI has been found in the literature.

    Methods: an electronic systematic literature search was conducted in August 2016 using four databases (Embase, Medline, CINAHL and PsycINFO) for prospective cohort studies published in 2000 or later, examining the mortality risk according to frailty measured by FI. Read More

    Dilemmas for guardians of advanced dementia patients regarding tube feeding.
    Age Ageing 2017 Oct 13:1-6. Epub 2017 Oct 13.
    The Cheryl Spencer Department of Nursing, University of Haifa, Haifa, Israel.
    Background: advanced dementia is an incurable illness, its last stage marked by inability to eat. Tube feeding was deemed a helpful solution at this stage, but in recent years its inefficiency has been proved, and it is no longer practiced in many countries around the world. In Israel, however, the procedure is still accepted. Read More

    Medication usage change in older people (65+) in England over 20 years: findings from CFAS I and CFAS II.
    Age Ageing 2017 Sep 26:1-6. Epub 2017 Sep 26.
    Department of Public Health and Primary Care, Cambridge Institute of Public Health, Cambridge, UK.
    Background: medical practice has changed over the last decades reflecting the ageing population, when multi-morbidity requiring multiple medications is more common.

    Objective: describe and quantify self-reported medicine use including both prescription and over the counter medicines in two comparable population-based studies of older people (65+) in England and to assess the nature and scale of polypharmacy.

    Methods: data used were from two separate population-based studies; the Cognitive Function Ageing Study I and II. Read More

    Frailty and healthcare costs-longitudinal results of a prospective cohort study.
    Age Ageing 2017 Sep 21:1-9. Epub 2017 Sep 21.
    Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Objective: to investigate how frailty and frailty symptoms affect healthcare costs in older age longitudinally.

    Methods: data were gathered from a prospective cohort study in Saarland, Germany (two waves with 3-year interval, n = 1,636 aged 57-84 years at baseline). Frailty was assessed by the five Fried frailty criteria. Read More

    A prospective observational study to investigate utility of the Delirium Observational Screening Scale (DOSS) to detect delirium in care home residents.
    Age Ageing 2017 Oct 5:1-6. Epub 2017 Oct 5.
    Academic Unit of Elderly Care and Rehabilitation, Bradford Institute for Health Research, University of Leeds, Bradford, UK.
    Background: care home residents are particularly at risk of delirium due to high prevalence of dementia. The Delirium Observation Screening Scale (DOSS) identifies behavioural changes associated delirium onset that nursing staff are uniquely placed to recognise. We tested the psychometric properties of the DOSS in UK care homes compared with the Confusion Assessment Method (CAM). Read More

    Multimorbidity: will it stand the test of time?
    Age Ageing 2017 Sep 26:1-3. Epub 2017 Sep 26.
    Norwich Medical School, University of East Anglia, UK.
    The concept of multimorbidity has risen in popularity over the past few years. It is use has led to, or coincided with, an increased recognition that patients often have more than one health problem which should not be treated in isolation. The motivation for more holistic, person-centred care that lies behind multimorbidity is to be welcomed. Read More

    Self-rated health and its association with mortality in older adults in China, India and Latin America-a 10/66 Dementia Research Group study.
    Age Ageing 2017 Nov;46(6):932-939
    Health Services and Population Research Department, Psychology and Neuroscience, Centre for Global Mental Health, Institute of Psychiatry, King's College London, Strand, London WC2R2LS, UK.
    Background: empirical evidence from high-income countries suggests that self-rated health (SRH) is useful as a brief and simple outcome measure in public health research. However, in many low- and middle-income countries (LMIC) there is a lack of evaluation and the cross-cultural validity of SRH remains largely untested. This study aims to explore the prevalence of SRH and its association with mortality in older adults in LMIC in order to cross-culturally validate the construct of SRH. Read More

    Home-based telerehabilitation in older patients with chronic obstructive pulmonary disease and heart failure: a randomised controlled trial.
    Age Ageing 2017 Aug 30:1-7. Epub 2017 Aug 30.
    Care Continuity Unit and Telemedicine Service, Istituti Clinici Scientifici Maugeri IRCCS, Lumezzane, Brescia, Italy.
    Background: chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) frequently coexist in older people, reducing patients' quality of life (QoL) and increasing morbidity and mortality.

    Objective: we studied the feasibility and efficacy of an integrated telerehabilitation home-based programme (Telereab-HBP), 4 months long, in patients with combined COPD and CHF. The primary outcome was exercise tolerance evaluated at the 6-min walk test (6MWT). Read More

    Outcomes of Mobilisation of Vulnerable Elders in Ontario (MOVE ON): a multisite interrupted time series evaluation of an implementation intervention to increase patient mobilisation.
    Age Ageing 2017 Jul 15:1-7. Epub 2017 Jul 15.
    Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
    Background: older patients admitted to hospitals are at risk for hospital-acquired morbidity related to immobility. The aim of this study was to implement and evaluate an evidence-based intervention targeting staff to promote early mobilisation in older patients admitted to general medical inpatient units.

    Methods: the early mobilisation implementation intervention for staff was multi-component and tailored to local context at 14 academic hospitals in Ontario, Canada. Read More

    Shared genetic influence on frailty and chronic widespread pain: a study from TwinsUK.
    Age Ageing 2017 Jul 7:1-7. Epub 2017 Jul 7.
    Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
    Introduction: frailty is an increased vulnerability to adverse health outcomes, across multiple physiological systems, with both environmental and genetic drivers. The two most commonly used measures are Rockwood's frailty index (FI) and Fried's frailty phenotype (FP).

    Material And Methods: the present study included 3626 individuals from the TwinsUK Adult Twin Registry. Read More

    Is orthostatic hypotension more common in individuals with atrial fibrillation?-Findings from The Irish Longitudinal Study on Ageing (TILDA).
    Age Ageing 2017 Nov;46(6):1006-1010
    The Irish Longitudinal Study on Ageing, Lincoln gate, Trinity College Dublin, Dublin, Ireland.
    Introduction: atrial fibrillation (AF) and orthostatic hypotension (OH) share common risk factors such as age, hypertension and cardiovascular (CV) disease. The autonomic nervous system (ANS) also plays a role in the pathogenesis of both AF and OH. The aim of this study is to assess whether individuals with AF are more likely to have OH than those without AF. Read More

    Health-related quality of life in older patients with acute coronary syndrome randomised to an invasive or conservative strategy. The After Eighty randomised controlled trial.
    Age Ageing 2017 Jul 13:1-7. Epub 2017 Jul 13.
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
    Objective: in the After Eighty study (ClinicalTrials.gov.number, NCT01255540), patients aged 80 years or more, with non-ST-elevation myocardial infarction (NSTEMI), and unstable angina pectoris (UAP), were randomised to either an invasive or conservative management approach. Read More

    The effect of perindopril on postural instability in older people with a history of falls-a randomised controlled trial.
    Age Ageing 2017 Jul 11:1-7. Epub 2017 Jul 11.
    Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
    Design: double-blind, parallel group, placebo-controlled randomised trial.

    Methods: we recruited people aged >65 years with at least one fall in the previous year. Participants received 4 mg perindopril or placebo daily for 15 weeks. Read More

    Evaluating physical activity in dementia: a systematic review of outcomes to inform the development of a core outcome set.
    Age Ageing 2017 Aug 9:1-8. Epub 2017 Aug 9.
    Faculty of Health Sciences, University of Southampton, Southampton SO17 1BJ, UK.
    Background: physical activity is recommended for people living with dementia, but evidence for the positive effects of physical activity is limited by the use of heterogeneous outcomes and measurement tools. This systematic literature review aimed to summarise previously reported outcomes and identify the measurement tools used most frequently in physical activity interventions for people with dementia.

    Methods: literature searches were conducted in April 2015, on Delphis and Medline. Read More

    Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees.
    Age Ageing 2017 Sep 1:1-7. Epub 2017 Sep 1.
    Centre for Gerontology and Rehabilitation, School of Medicine, University College Cork, Cork, Ireland.
    Background: screening for cognitive impairment in Emergency Department (ED) requires short, reliable tools.

    Objective: to validate the 4AT and 6-Item Cognitive Impairment Test (6-CIT) for ED dementia and delirium screening.

    Design: diagnostic accuracy study. Read More

    Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-regression analysis.
    Age Ageing 2017 Sep 8:1-9. Epub 2017 Sep 8.
    Institute of Cardiovascular Sciences, University of Birmingham, Birmingham B18 7QH, UK.
    Background And Objective: the study analysed the effectiveness and safety of warfarin use compared with warfarin non-use and non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients aged ≥65 years.

    Methods: after searching PubMed and the Cochrane Library, 26 studies were included, with 10 comparing warfarin with warfarin non-use and 16 comparing warfarin with NOACs, in older AF patients (≥65 years).

    Results: warfarin use was superior to no antithrombotic therapy [relative risk (RR) 0. Read More

    Potentially inappropriate medication among people with dementia in eight European countries.
    Age Ageing 2017 Sep 1:1-7. Epub 2017 Sep 1.
    School of Nursing Science, University of Witten/Herdecke, Witten, Germany.
    Objectives: to evaluate the frequency of potentially inappropriate medication (PIM) prescription among older people with dementia (PwD) from eight countries participating in the European study 'RightTimePlaceCare', and to evaluate factors and adverse outcomes associated with PIM prescription.

    Methods: survey of 2,004 PwD including a baseline assessment and follow-up after 3 months. Interviewers gathered data on age, sex, prescription of medication, cognitive status, functional status, comorbidity, setting and admission to hospital, fall-related injuries and mortality in the time between baseline and follow-up. Read More

    Does current smoking predict future frailty? The English longitudinal study of ageing.
    Age Ageing 2017 Aug 17:1-6. Epub 2017 Aug 17.
    Department of Primary Care and Population Health, University College London, London, UK.
    Background: smoking is the single most preventable cause of morbidity and mortality. The evidence on independent associations between smoking in later life and incident frailty is scarce.

    Objectives: to examine the effect of current smoking in older people on the risk of developing frailty, controlling for important confounders. Read More

    Haloperidol versus placebo for delirium prevention in acutely hospitalised older at risk patients: a multi-centre double-blind randomised controlled clinical trial.
    Age Ageing 2017 Jul 15:1-8. Epub 2017 Jul 15.
    Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands.
    Background: because the few randomised placebo-controlled trials investigating the potential role for prophylactic haloperidol in delirium prevention have focused on specific surgical populations, we investigated its efficacy and safety in acutely hospitalised older patients.

    Methods: this multi-centre, double-blind, stratified, block randomised, placebo-controlled trial was conducted at six Dutch hospitals. Patients age ≥70 years, acutely admitted through the emergency department for general medicine or surgical specialties and at risk for delirium were randomised (n = 245) to haloperidol or placebo 1 mg orally twice-daily (maximum of 14 doses) on top of standard nonpharmacological prevention strategies. Read More

    Age- and sex-based recovery curves to track functional outcomes in older adults with total knee arthroplasty.
    Age Ageing 2017 Aug 30:1-5. Epub 2017 Aug 30.
    Department of Physiotherapy, Singapore General Hospital, Singapore.
    Background: older adults with total knee arthroplasty (TKA) frequently undergo rehabilitation to address limited knee flexion range-of-motion, quadriceps weakness and gait speed limitations. This study aimed to develop age- and sex-specific recovery curves of knee flexion range-of-motion, quadriceps strength and fast gait speed post-TKA.

    Methods: a population-based sample of 2,987 patients undergoing primary TKA participated, of whom 2015 (68%) were 65 years of age or older. Read More

    Interventions to prevent and reduce excessive alcohol consumption in older people: a systematic review and meta-analysis.
    Age Ageing 2017 Jul 20:1-10. Epub 2017 Jul 20.
    Cambridge Institute of Public Health, Forvie Site, University of Cambridge School of Clinical Medicine, Box 113, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK.
    Background: harmful alcohol consumption is reported to be increasing in older people. To intervene and reduce associated risks, evidence currently available needs to be identified.

    Methods: two systematic reviews in older populations (55+ years): (1) Interventions to prevent or reduce excessive alcohol consumption; (2) Interventions as (1) also reporting cognitive and dementia outcomes. Read More

    Occupational social and mental stimulation and cognitive decline with advancing age.
    Age Ageing 2017 Jul 27:1-6. Epub 2017 Jul 27.
    University of Bordeaux, INSERM, UMR 1219, ISPED, F-33076 Bordeaux, France.
    Objective: this study investigates the role of social and mental occupational characteristics in cognitive decline after retirement.

    Methods: the study included 1,048 subjects aged ≥65 years from the Three City cohort. Participants were evaluated at home at the initial visit and at 2-year intervals for a period of 12 years. Read More

    New horizons in multimorbidity in older adults.
    Age Ageing 2017 Nov;46(6):882-888
    School of Psychology, Bangor University, Bangor, UK.
    The concept of multimorbidity has attracted growing interest over recent years, and more latterly with the publication of specific guidelines on multimorbidity by the National Institute for Health and Care Excellence (NICE). Increasingly it is recognised that this is of particular relevance to practitioners caring for older adults, where multimorbidity may be more complex due to the overlap of physical and mental health disorders, frailty and polypharmacy. The overlap of frailty and multimorbidity in particular is likely to be due to the widespread health deficit accumulation, leading in some cases to functional impairment. Read More

    Trajectory of social isolation following hip fracture: an analysis of the English Longitudinal Study of Ageing (ELSA) cohort.
    Age Ageing 2017 Jul 19:1-6. Epub 2017 Jul 19.
    Norwich Medical School, University of East Anglia, Norwich, UK.
    Background: social isolation is defined as a lack of meaningful and sustained communication or interactions with social networks. There is limited understanding on the prevalence of social isolation and loneliness in people following hip fracture and no previous understanding of how this changes over time.

    Objective: to determine the prevalence and trajectory of social isolation and loneliness before a hip fracture, during the recovery phase and a minimum of 2 years post-hip fracture in an English population. Read More

    Conducting and reporting trials for older people.
    Age Ageing 2017 Nov;46(6):889-894
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
    Randomised controlled trials provide the most rigorous test of efficacy and effectiveness for interventions used in healthcare. They underpin much of clinical practice, yet older people are often excluded from studies, resulting in uncertainty about risks and benefits of new treatments. Encouraging inclusion of older people in randomised controlled trials and reporting of trial results in a rigorous manner is a key function of clinical geriatrics journals such as Age and Ageing. Read More

    Development of an international undergraduate curriculum for delirium using a modified delphi process.
    Age Ageing 2017 Aug 9:1-7. Epub 2017 Aug 9.
    School of Medicine, Griffith University, Queensland, Australia.
    Background: delirium is a medical emergency affecting approximately 30% of hospitalised older patients. Recent work examining UK undergraduate medical curricula highlighted inconsistencies in the delivery of teaching on delirium. The aim of this project was to develop consensus agreement on a delirium curriculum for medical undergraduates. Read More

    The effect of complex interventions on supporting self-care among community-dwelling older adults: a systematic review and meta-analysis.
    Age Ageing 2017 Sep 13:1-9. Epub 2017 Sep 13.
    School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
    Background: self-care is critical to enable community-dwelling older adults to live independently. Complex interventions have emerged as a strategy to support self-care, but their effectiveness is unknown. Our objective was to review systematically their effectiveness on both positive (increased scores in self-rated health, Activities of Daily Living, Instrumental Activities of Daily Living, quality of life) and negative aspects (increased incidence of falls, fear of falling, hospital and nursing home admission, increased depression score), and to determine which intervention components explain the observed effects. Read More

    New horizons in comprehensive geriatric assessment.
    Age Ageing 2017 Sep;46(5):713-721
    Department of Health Sciences, College of Medicine, Biological Sciences and Psychology, University of Leicester, Centre for Medicine, Leicester LE1 7RH, UK.
    In this article, we discuss the emergence of new models for delivery of comprehensive geriatric assessment (CGA) in the acute hospital setting. CGA is the core technology of Geriatric Medicine and for hospital inpatients it improves key outcomes such as survival, time spent at home and institutionalisation. Traditionally It is delivered by specialised multidisciplinary teams, often in dedicated wards, but in recent years has begun to be taken up and developed quite early in the admission process (at the 'front door'), across traditional ward boundaries and in specialty settings such as surgical and pre-operative care, and oncology. Read More

    Associations of acetylcholinesterase inhibitor treatment with reduced mortality in Alzheimer's disease: a retrospective survival analysis.
    Age Ageing 2017 Jun 24:1-7. Epub 2017 Jun 24.
    King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
    Background: dementia is increasingly recognised as life-limiting condition. Although the benefits of acetylcholinesterase inhibitors (AChEIs) on cognition and function are well established, their effect on survival is less clear.

    Objective: to investigate associations between AChEI prescription and mortality in patients with Alzheimer's dementia (AD) in a naturalistic setting, using detailed baseline data on cognition, functioning, and mental and physical wellbeing. Read More

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