2,348,307 results match your criteria Age and ageing[Journal]
Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.
Group of Research in Nutrition and Chronic Diseases, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
Objective: To assess the association between dietary glycemic index (GI) and excess weight in pregnant women in the first trimester of pregnancy.
Methods: A cross-sectional study in a sample of 217 pregnant women was conducted at the maternal-fetal outpatient clinic of the Hospital Geral de Fortaleza, Fortaleza, state of Ceará, Brazil, for routine ultrasound examinations in the period between 11 and 13 weeks + 6 days of gestation. Weight and height were measured and the gestational body mass index (BMI) was calculated. Read More
Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.
Department of Radiology and Oncology, Universidade de São Paulo, São Paulo, SP, Brazil.
Objective: To promote informed choice for women and to compare home and hospital births in relation to the Apgar score.
Methods: Mother's profile and Apgar score of naturally born infants (without forceps assistance) in Brazil between 2011 and 2015, in both settings-hospital or home-were collected from live birth records provided by the Informatics Department of the Unified Health System (DATASUS, in the Portuguese acronym). For the analysis, were included only data from low-risk deliveries, including gestational time between 37 and 41 weeks, singleton pregnancy, at least four visits of prenatal care, infants weighing between 2,500 g, and 4,000 g, mother age between 20-40 years old, and absence of congenital anomalies. Read More
Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.
Universidade Positivo, Curitiba, PR, Brazil.
Renal artery aneurysms (RAAs) are rare and usually asymptomatic; ∼ 90% of them are unilateral. Once diagnosed during pregnancy, they may rupture, presenting a high maternal-fetal risk. The present study reports the case of a 32-year-old pregnant woman with a 30-week gestational age and a ruptured unilateral RAA. Read More
Exp Clin Endocrinol Diabetes 2018 Dec 12. Epub 2018 Dec 12.
Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan.
Objective: Sarcopenia has been recognized as a diabetic complication, and hyperuricemia is often accompanied by type 2 diabetes mellitus (T2DM). However, it is unknown whether serum uric acid (UA) levels are associated with reduced muscle mass in T2DM.
Methods: We conducted a cross-sectional study to investigate the association of serum UA with muscle mass in 401 subjects with T2DM (209 men and 192 postmenopausal women). Read More
QJM 2018 Dec 12. Epub 2018 Dec 12.
Clinical Sciences Institute, National University of Ireland, Galway (NUIG), Galway City, Ireland.
Background: Burden of disease (BoD) using disability-adjusted life years (DALY) is a useful summary measure of population health and estimates are provided for Ireland annually. We hypothesised that BoD may be used as a predictor of frailty prevalence.
Aim: To examine the correlation between frailty measured by the accumulation of deficits (frailty index, FI) and Fried Frailty Phenotype (FFP) classifications and BoD, in an Irish context. Read More
J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.
Department of Radiology, Akershus University Hospital, Lørenskog, Norway.
Background: Crohns disease (CD) is a chronic inflammation in the gut that often progresses to fibrosis. Magnetic Resonance Enterography (MRE) is an important diagnostic tool in evaluating CD. We aimed to assess the prevalence of inflammation and stricturing disease in patients with long-term CD and investigate associations with clinical factors. Read More
J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.
Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Background: Differential transmission from HIV-infected compared to HIV-uninfected individuals may impact influenza burden. We estimated the household secondary infection risk (SIR) and serial interval (SI) for influenza transmission from HIV-infected and HIV-uninfected index cases and identified associated factors.
Methods: Index cases were the first symptomatic person in a household with influenza-like illness, testing influenza positive on real-time reverse transcription polymerase chain reaction (rRT-PCR). Read More
Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.
Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.
Objectives: To evaluate the effectiveness of lung cancer screening using low-dose computed tomography for the general population, we conducted a retrospective cohort study of screening for participants among Hitachi residents.
Materials And Methods: Citizens aged 50-74 who underwent low-dose computed tomography screening at least once during 1998-2006 were defined as the computed tomography group, and those who underwent X-ray screening at least once during the same period, but did not receive low-dose computed tomography screening throughout the follow-up period, were defined as the XP group. We investigated the lung cancer incidence rate, mortality rate and all-cause mortality rate for both groups from the first lung cancer screening to the end of 2012. Read More
J Am Med Inform Assoc 2018 Dec;25(12):1634-1642
Emory University School of Medicine, Atlanta, GA, USA.
Background: The prevalence of moderate or complex (moderate-complex) congenital heart defects (CHDs) among adults is increasing due to improved survival, but many patients experience lapses in specialty care or their CHDs are undocumented in the medical system. There is, to date, no efficient approach to identify this population.
Objective: To develop and assess the performance of a risk score to identify adults aged 20-60 years with undocumented specific moderate-complex CHDs from electronic health records (EHR). Read More
J Antimicrob Chemother 2018 Dec 12. Epub 2018 Dec 12.
Department of Medical and Surgical Sciences, Unit of Infectious Diseases, 'Alma Mater Studiorum' University of Bologna, S. Orsola-Malpighi Hospital, via Massarenti 11, Bologna, Italy.
Objectives: An observational, prospective, cohort study was performed to assess changes in insulin sensitivity and serum leptin level after a switch from a ritonavir-boosted PI (PI/r) to raltegravir or dolutegravir in HIV-infected adults on stable combination ART (cART).
Methods: Non-diabetic HIV-infected patients receiving suppressive cART including tenofovir disoproxil fumarate/emtricitabine plus one PI/r, who underwent a switch from the PI/r to raltegravir (group A) or dolutegravir (group B), were enrolled in the study. Serum levels of insulin, leptin and the homeostasis model assessment of insulin resistance (HOMA) index were evaluated during a 12 month follow-up. Read More
Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.
Department of Neurology, Paracelsus Medical University, Salzburg, Austria.
Background: Flow diversion has become an accepted endovascular treatment modality for intracranial aneurysms. Studies comparing different types of flow diverters are currently lacking.
Objective: To perform a propensity score-matched cohort study comparing the Pipeline Embolization Device (PED; Medtronic, Dublin, Ireland) and Flow Redirection Endoluminal Device (FRED; MicroVention, Aliso Viejo, California). Read More
Sleep 2018 Dec 12. Epub 2018 Dec 12.
Department of Psychiatry and Behavioral Sciences.
Study Objectives: This study aims to evaluate the extent to which sleep quality impacts amnestic mild cognitive impairment (aMCI)-related brain regions in a cognitively normal cohort of individuals.
Methods: Seventy four participants were rigorously evaluated using a battery of cognitive tests and a detailed clinical assessment to verify normal cognitive status. We then screened for sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and depressive symptoms using the Geriatric Depression Scale (GDS). Read More
Am J Clin Nutr 2018 Dec;108(6):1196-1208
Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
Background: There is great overlap between the presentation of cachexia, sarcopenia, and malnutrition. Distinguishing between these conditions would allow for better targeted treatment for patients.
Objectives: The aim was to systematically review validated screening tools for cachexia, sarcopenia, and malnutrition in adults and, if a combined tool is absent, make suggestions for the generation of a novel screening tool. Read More
Am J Clin Nutr 2018 Dec;108(6):1316-1323
Institute of Applied Health Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
Background: Some research suggests that parent or carer feeding practices may influence children's weight patterns, but longitudinal evidence is limited and inconsistent.
Objective: The aim of this study was to investigate the relation between various parent or carer feeding practices when a child is aged 7-8 y and proxy measurements of child adiposity at age 8-9 y (weight status, waist-to-height ratio, and body fat percentage).
Design: The study was a secondary analysis of data from the West Midlands Active Lifestyle and Healthy Eating in Schoolchildren (WAVES) Study comprising a diverse sample of parents and carers and their children from 54 primary schools in the West Midlands, England [n = 774 parent-child dyads (53% of the WAVES study sample)]. Read More
Am J Clin Nutr 2018 Dec;108(6):1342-1351
Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research.
Background: Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population.
Objective: We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Read More
Gerontologist 2018 Dec 12. Epub 2018 Dec 12.
Virginia Tech Center for Gerontology, Virginia Polytechnic Institute and State University, Blacksburg.
Background And Objectives: Older adults with HIV face greater health burden than HIV-uninfected counterparts. Little is known about resources that might mediate the influence of physiological health burden on psychological well-being. Informed by the stress process model, we assessed the influence of multifaceted health burden indicators on depressive symptoms and evaluated the mediating effects of social support adequacy. Read More
Fam Pract 2018 Dec 12. Epub 2018 Dec 12.
The Health Improvement Institute (THIS), University of Cambridge, Cambridge, UK.
Background: Large variation in measures of diagnostic activity has been described previously between English general practices, but related predictors remain understudied.
Objective: To examine associations between general practice population and characteristics, with the use of urgent referrals for suspected cancer, and use of endoscopy.
Methods: Cross-sectional observational study of English general practices. Read More
Gerontologist 2018 Dec 12. Epub 2018 Dec 12.
Department of Psychiatry, University of California, San Diego.
Background And Objective: As HIV-infected (HIV+) individuals age, there is a need to understand successful aging (SA) from the patient perspective. This study compared SA definitions between HIV+ and HIV-uninfected (HIV-) older adults and then examined correlates of SA categories.
Research Design And Methods: Ninety-three HIV+ and 46 HIV- older (aged 50+) adults provided brief definitions of SA, which was examined using content analysis. Read More
Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.
Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.
Department of Biosystems Science and Engineering, ETH Zurich, Basel, 4058, Switzerland SIB Swiss Institute of Bioinformatics.
Summary: Combinatorial association mapping aims to assess the statistical association of higher-order interactions between genetic markers with a phenotype of interest. This paper presents CASMAP, a software package that leverages recent advances in significant pattern mining to overcome the statistical and computational challenges that have hindered combinatorial association mapping. CASMAP can be used to perform region-based association studies and to detect higher-order epistatic interactions of genetic variants. Read More
Plant Cell Physiol 2018 Dec;59(12):2549-2563
CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan, China.
Jatropha curcas is a promising feedstock for biofuel production because its oil is highly suitable for processing bio-jet fuels and biodiesel. However, Jatropha exhibits a long juvenile stage in subtropical areas. miR172, a conserved small non-protein-coding RNA molecule with 21 nucleotides, regulates a wide range of developmental processes. Read More
Pain Med 2018 Dec 12. Epub 2018 Dec 12.
College of Nursing, The University of Iowa, Iowa City, Iowa, USA.
Objective: To explore and describe older African Americans' patterns and perceptions of managing chronic osteoarthritis pain.
Methods: A convergent parallel mixed-methods design incorporating cross-sectional surveys and individual, semistructured interviews.
Setting: One hundred ten African Americans (≥50 years of age) with clinical osteoarthritis (OA) or provider-diagnosed OA from communities in northern Louisiana were enrolled. Read More
Int J Epidemiol 2018 Dec 11. Epub 2018 Dec 11.
Charles Perkins Centre, University of Sydney, Sydney, Australia.
Background: The purpose of a negative control is to reproduce a condition that cannot involve the hypothesized causal mechanism, but does involve the same sources of bias and confounding that may distort the primary association of interest. Observational studies suggest physical inactivity is a major risk factor for cardiovascular disease (CVD), although potential sources of bias, including reverse causation and residual confounding, make it difficult to infer causality. The aim was to employ a negative control outcome to explore the extent to which the association between physical activity and CVD mortality is explained by confounding. Read More
Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.
Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Kettegård Allé 26, Hvidovre, Denmark.
Study Question: Is the number of aspirated oocytes in the first ART cycle associated with the cumulative live birthrates (CLBR) in subsequent cycles?
Summary Answer: The number of aspirated oocytes in the first cycle was associated with CLBR in subsequent cycles. Previous treatment response predicts outcome in future cycles.
What Is Known Already: Previous reports have shown a positive association between the number of retrieved oocytes and live birthrate per fresh treatment cycle. Read More
Hum Reprod Update 2018 Dec 12. Epub 2018 Dec 12.
Priority Research Centre for Reproductive Science, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW, Australia.
Background: DNA integrity and stability are critical determinants of cell viability. This is especially true in the female germline, wherein DNA integrity underpins successful conception, embryonic development, pregnancy and the production of healthy offspring. However, DNA is not inert; rather, it is subject to assault from various environment factors resulting in chemical modification and/or strand breakage. Read More
Int J Epidemiol 2018 Dec 11. Epub 2018 Dec 11.
Institute for Global Health, University College London, London, UK.
Background: The extent to which individuals are similar to their sexual partners influences STI-transmission probabilities, yet there is a dearth of empirical data, especially those representative of the population.
Methods: Analyses of data reported by 10 759 sexually active people aged 16-74 y interviewed for a British national probability survey undertaken in 2010-12. Computer-assisted self-interviews asked about partner numbers and characteristics of participants' three most recent partnerships (MRPs). Read More
Folia Phoniatr Logop 2018 Dec 12;71(1):24-28. Epub 2018 Dec 12.
Audiology Department, Faculty of Health Sciences, Uskudar University, Istanbul, Turkey.
Purpose: To investigate the formant frequency (FF) features of transgender females' (TFs) voice after Wendler's glottoplasty surgery and compare these levels with age-matched healthy males and females.
Study Design: Controlled prospective.
Methods: 20 TFs and 20 genetically male and female age-matched healthy controls were enrolled in the study. Read More
Folia Phoniatr Logop 2018 Dec 12;71(1):42-55. Epub 2018 Dec 12.
Department of Speech-Language Pathology, University of Toronto, Toronto, Ontario, Canada.
Background/aims: Specific language impairment (SLI) is characterized by deficits in language ability. However, studies have also reported motor impairments in SLI. It has been proposed that the language and motor impairments in SLI share common origins. Read More
Dig Surg 2018 Dec 12:1-8. Epub 2018 Dec 12.
Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona,
Background: The prevalence of symptoms in pancreatic cystic neoplasms (PCNs) is mainly based on retrospective surgical series. The aim of this study is to describe the actual prevalence of symptoms in PCNs under surveillance.
Methods: Patients with PCNs under surveillance observed from 2015 to 2017 were submitted to magnetic resonance imaging (MRI) and a specific interview. Read More
Ann Nutr Metab 2018 Dec 12;74(1):44-52. Epub 2018 Dec 12.
Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou,
Background/aims: Some adipokines, such as adiponectin and leptin, have been reported to be involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), while the association of adipsin and visfatin with NAFLD still remains unclear. This study aimed to examine the association of circulating adipsin, visfatin, and adiponectin with NAFLD in Chinese adults.
Methods: We recruited a total of 211 eligible subjects, including 100 NAFLD cases and 111 age and sex frequency-matched controls. Read More
Audiol Neurootol 2018 Dec 12;23(5):298-308. Epub 2018 Dec 12.
Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
The aim of this study was to investigate changes in balance control for stance and gait tasks in patients 2 years before and after vestibular neurectomy (VN) performed to alleviate intractable Meniere's disease. Amplitudes of trunk sway in roll and pitch directions were measured for stance and gait tasks in 19 patients using gyroscopes mounted at the lower-back. Measurements before VN and 2 years later were compared to those of healthy age-matched controls (HC). Read More
Digestion 2018 Dec 12:1-7. Epub 2018 Dec 12.
Department of Internal Medicine, Saga Medical School, Saga, Japan.
Background: Leukocyte removal therapy (LRT) is an effective treatment for active ulcerative colitis (UC). The present study was performed to evaluate the relapse-free period after LRT and identify risk factors for relapse.
Methods: In total, 94 patients who underwent first-time LRT for remission of moderate to severe UC from April 2004 to March 2016 were enrolled in the present study. Read More
Gynecol Obstet Invest 2018 Dec 12:1-7. Epub 2018 Dec 12.
Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan,
Objective: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis.
Methods And Materials: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated. Read More
Cell Rep 2018 Dec;25(11):2992-3005.e5
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:
Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. However, with age, the balance is disrupted, and LT-HSCs produce a myeloid-biased output, resulting in poor immune responses to infectious challenge and the development of myeloid leukemias. Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. Read More
Dentomaxillofac Radiol 2018 Dec 12:20180184. Epub 2018 Dec 12.
1 Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz , Mainz , Germany.
Objective:: CBCT often use a smaller field of view compared to conventional CT scans. This might lead to a wrong field of view with the need for secondary exposure ("retakes"). The purpose of this retrospective study was to assess the frequency of re-exposures in cone beam computed tomography (CBCT) and to identify whether the parameters age, gender and FOV have an influence on the re-exposure of the patient. Read More
Ear Nose Throat J 2018 Dec;97(12):E7-E10
University of Arizona College of Medicine - Tucson, 1501 N. Campbell Ave., PO Box 245017, Tucson, AZ 85724, USA.
Cystic neck masses in the pediatric population are common but rarely concerning for malignancy. Given this typically benign nature, they are frequently managed conservatively. Here we present an unusual case of a waxing and waning cystic neck mass in a pediatric patient. Read More
Orthopedics 2018 Dec 11:1-5. Epub 2018 Dec 11.
No study has compared the prevalence of fretting and corrosion at the trunnion of cobalt-chrome (Co-Cr) and zirconia ceramic heads in the same patients. The authors sought to compare the prevalence of fretting and corrosion at the trunnion after total hip arthroplasty with a 32-mm Co-Cr or a 32-mm zirconia ceramic head-on-polyethylene bearing. Isolated revision of the ace-tabular components was performed in 78 patients (156 hips) for polyethylene wear and osteolysis of the acetabulum. Read More
J Speech Lang Hear Res 2018 Dec 11:1-10. Epub 2018 Dec 11.
Department of Neuroscience, University of Arizona, Tucson.
Purpose: The zebra finch is used as a model to study the neural circuitry of auditory-guided human vocal production. The terminology of birdsong production and acoustic analysis, however, differs from human voice production, making it difficult for voice researchers of either species to navigate the literature from the other. The purpose of this research note is to identify common terminology and measures to better compare information across species. Read More
Magy Onkol 2018 Dec 22;62(4):237-241. Epub 2018 Nov 22.
II. Sz. Gyermekgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary.
The atypical teratoid/rhabdoid tumour (ATRT) is a rare type of central nervous system tumour appearing usually under 2 years of age. The survival of patients is insufficient despite the combined treatment (neurosurgical removal, intensive chemo- and radiotherapy). ATRT recurs one year after completion of treatment in 60% of cases. Read More
Magy Onkol 2018 Dec 19;62(4):230-236. Epub 2018 Oct 19.
II. Sz. Gyermekgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary.
The survival of children treated with Ewing sarcoma at Semmelweis University were investigated. Pediatric patients with Ewing sarcoma treated at Semmelweis University from 2001 through 2013 were analyzed in terms of overall survival and clinical factors (age, primary localization and extent of the tumor, time interval from primary complaints to diagnosis). For statistical analysis Kaplan-Meier estimated survival and log rank test were applied. Read More
Magy Onkol 2018 Dec 15;62(4):204-213. Epub 2018 Oct 15.
Gyermekgyógyászati Intézet, Gyermekhematológiai-onkológiai nem önálló Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar, Debrecen, Hungary.
Classification, staging and treatment response criteria of pediatric NHL have been revised. Long-term survival reaches ~90% at the expense of severe acute toxicities. The outcome of refractory and relapsed cases is poor. Read More
PLoS One 2018 12;13(12):e0208914. Epub 2018 Dec 12.
Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Background And Aims: Patients who leave Emergency Department before physician's visit (LWBS) or during treatment (LDT) represent a useful indicator of the emergency care's quality. The profile of patients LWBS was described: they are generally males, young, with lower urgency triage allocation and longer waiting time. They have a greater risk of ED re-admission compared to discharged patients, but effect on hospitalization and mortality are more controversial. Read More
PLoS One 2018 12;13(12):e0208796. Epub 2018 Dec 12.
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.
Background: The number of patients with diabetes is increasing particularly in Asia-Pacific region. Many of them are treated with antidiabetics. As the basis of the studies on the benefit and harm of antidiabetic drugs in the region, the information on patterns of market penetration of new classes of antidiabetic medications is important in providing context for subsequent research and analyzing and interpreting results. Read More
PLoS One 2018 12;13(12):e0209013. Epub 2018 Dec 12.
Fort Collins Science Center, U.S. Geological Survey, Fort Collins, Colorado, United States of America.
How information is communicated influences the public's environmental perceptions and behaviors. Information channels and sources both play an important role in the dissemination of information. Trust in a source is often used as a proxy for whether a particular piece of information is credible. Read More
PLoS One 2018 12;13(12):e0208539. Epub 2018 Dec 12.
The Department of Family Medicine, The Sackler Faculty of Medicine, University of Tel Aviv, Tel-Aviv, Israel.
Objectives: Disease registry for diabetes care encourages transparency and benchmarking of quality of care (QoC) measurements for all service providers and seems to improve diabetes care. This study evaluate changes over time in QoC measurement performance in a large diabetes registry among newly diagnosed diabetics and it association with mortality.
Methods: Retrospective cohort study of patients in a large health maintenance organization diabetes registry from years 2000 to 2013. Read More
PLoS One 2018 12;13(12):e0208920. Epub 2018 Dec 12.
Department of Clinical Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Bortezomib, a first generation proteasome inhibitor, is used in both newly diagnosed and relapsed myeloma settings. Considerable differences exist in the usage of bortezomib therapy in the clinical practice setting in comparison to clinical trial setting as well manufacturer's recommendations. These differences include route of administration (intravenous (iv) vs. Read More
PLoS One 2018 12;13(12):e0208950. Epub 2018 Dec 12.
Centre for Behavioural Research in Cancer, Cancer Council Victoria, Melbourne, Australia.
Background: Social denormalisation of smoking can provide an environment that helps smokers to quit. This study examined which of three measures of anti-smoking social norms have the greatest influence on quitting-related cognitions and behaviours, and if this influence differs according to socioeconomic status (SES).
Methods: The Victorian Tracking Survey measured social norms among 1,348 (n(weighted) = 1,373) Australian adult smokers (aged 18-59) between 2012 and 2014, who were followed-up one week later. Read More
PLoS One 2018 12;13(12):e0208488. Epub 2018 Dec 12.
Department of Animal Science, University of California, Davis, California, United States of America.
Determining the efficiency of amino acid (AA) utilization in growing animals is crucial to estimate their requirement accurately. In broiler chickens, the composition of AA in feather is different from feather-free body and the proportion of feathers will change along broiler's growth, which may impact the efficiency of utilization on AA consumed. Therefore, in order to establish a method that predicts the efficiency of utilization for feather-free body and feather, two approaches were evaluated: a multiple linear regression and a multivariate analysis. Read More
PLoS One 2018 12;13(12):e0209026. Epub 2018 Dec 12.
Department of Pediatrics, National Jewish Health, Denver, CO, United States of America.
Cystic fibrosis (CF) is the most common life-shortening genetic disease and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Several current therapies aim at improving availability and/or function of the mutant CFTR proteins. The combination therapeutic lumacaftor/ivacaftor (Orkambi, luma/iva) partially corrects folding and potentiates CFTR function impaired by the F508del mutation. Read More
PLoS One 2018 12;13(12):e0208252. Epub 2018 Dec 12.
Department of Pediatrics, University of Rennes 1,Rennes, France.
Introduction: Most infants born before 30 weeks gestational age (GA) develop respiratory distress syndrome soon after birth. Methods of surfactant administration that avoid ventilation have been recently introduced. The aim of this study was to evaluate the impact of implementing a new procedure of less invasive surfactant administration (LISA) and determine whether it is associated with an improvement in respiratory outcome. Read More