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    1 OF 101

    The effect of complex interventions on supporting self-care among community-dwelling older adults: a systematic review and meta-analysis.
    Age Ageing 2017 Sep 13:1-9. Epub 2017 Sep 13.
    School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
    Background: self-care is critical to enable community-dwelling older adults to live independently. Complex interventions have emerged as a strategy to support self-care, but their effectiveness is unknown. Our objective was to review systematically their effectiveness on both positive (increased scores in self-rated health, Activities of Daily Living, Instrumental Activities of Daily Living, quality of life) and negative aspects (increased incidence of falls, fear of falling, hospital and nursing home admission, increased depression score), and to determine which intervention components explain the observed effects. Read More

    New horizons in comprehensive geriatric assessment.
    Age Ageing 2017 Sep;46(5):713-721
    Department of Health Sciences, College of Medicine, Biological Sciences and Psychology, University of Leicester, Centre for Medicine, Leicester LE1 7RH, UK.
    In this article, we discuss the emergence of new models for delivery of comprehensive geriatric assessment (CGA) in the acute hospital setting. CGA is the core technology of Geriatric Medicine and for hospital inpatients it improves key outcomes such as survival, time spent at home and institutionalisation. Traditionally It is delivered by specialised multidisciplinary teams, often in dedicated wards, but in recent years has begun to be taken up and developed quite early in the admission process (at the 'front door'), across traditional ward boundaries and in specialty settings such as surgical and pre-operative care, and oncology. Read More

    Associations of acetylcholinesterase inhibitor treatment with reduced mortality in Alzheimer's disease: a retrospective survival analysis.
    Age Ageing 2017 Jun 24:1-7. Epub 2017 Jun 24.
    King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
    Background: dementia is increasingly recognised as life-limiting condition. Although the benefits of acetylcholinesterase inhibitors (AChEIs) on cognition and function are well established, their effect on survival is less clear.

    Objective: to investigate associations between AChEI prescription and mortality in patients with Alzheimer's dementia (AD) in a naturalistic setting, using detailed baseline data on cognition, functioning, and mental and physical wellbeing. Read More

    Hospital-at-home Integrated Care Programme for the management of disabling health crises in older patients: comparison with bed-based Intermediate Care.
    Age Ageing 2017 Jun 24:1-7. Epub 2017 Jun 24.
    Department of Medicine, Universitat Autònoma de Barcelona, Catalonia, Spain.
    Objective: to analyse the clinical impact of a home-based Intermediate Care model in the Catalan health system, comparing it with usual bed-based care.

    Design: quasi-experimental longitudinal study.

    Setting: hospital Municipal de Badalona and El Carme Intermediate Care Hospital, Badalona, Catalonia, Spain. Read More

    Systematic reviews: guidance relevant for studies of older people.
    Age Ageing 2017 Sep;46(5):722-728
    Department of Medicine, Health Research and Policy, Biomedical Data Science, and Statistics, and Meta-Research Innovation Center at Stanford (METRICS), Stanford University, California, USA.
    Systematic reviews and meta-analyses are increasingly common. This article aims to provide guidance for people conducting systematic reviews relevant to the healthcare of older people. An awareness of these issues will also help people reading systematic reviews to determine whether the results will influence their clinical practice. Read More

    Is sarcopenia associated with depression? A systematic review and meta-analysis of observational studies.
    Age Ageing 2017 Sep;46(5):738-746
    Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taiwan.
    Objectives: to explore whether sarcopenia is associated with depression.

    Design: electronic literature databases from PubMed, Scopus, Embase and Google Scholar were searched. A systematic review and meta-analysis of observational studies was conducted. Read More

    Correlates of dyspnoea and its association with adverse outcomes in a cohort of adults aged 80 and over.
    Age Ageing 2017 Jun 14:1-7. Epub 2017 Jun 14.
    Department of Public Health and Primary Care, Katholieke Universiteit Leuven, Leuven, Belgium.
    Background: adults aged 80 and over, a fast growing age-group, with increased co-morbidity and frailty have not been the focus of previous research on dyspnoea. We investigate the correlates of dyspnoea and its association with adverse outcomes in a cohort of adults aged 80 and over.

    Methods: about 565 community-dwelling adults aged 80 and over of the BELFRAIL prospective cohort had assessment of Medical Research Council dyspnoea scale (MRC), forced expiratory volume in 1 s (FEV1), N-terminal pro-brain natriuretic peptide (NT-proBNP), physical performance tests, grip strength, 15 items geriatric depression scale, activities of daily living (ADL), body mass index (BMI) and demographics data. Read More

    Circulating microRNAs as potential biomarkers for the identification of vascular dementia due to cerebral small vessel disease.
    Age Ageing 2017 Sep;46(5):861-864
    Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru 560029, Karnataka, India.
    Background: the diagnosis of cerebral small vessel disease, a leading cause of vascular dementia (VaD), relies solely on neuroimaging studies. Circulating microRNAs (miRNAs) have been proposed as diagnostic biomarkers in various disorders. Our aim was to identify differentially expressed, circulating miRNAs in small vessel VaD which could serve as diagnostic biomarkers for this disease. Read More

    Objectively measured physical activity and kidney function in older men; a cross-sectional population-based study.
    Age Ageing 2017 Jun 1:1-5. Epub 2017 Jun 1.
    UCL Department of Primary Care and Population Health, UCL Medical School, London NW3 2PF, UK.
    Background: kidney function declines in older adults and physical activity levels are low. We investigated whether higher levels of physical activity and lower levels of sedentary behaviour were associated with lower odds of low kidney function in older men.

    Methods: cross-sectional study of 1,352 men from the British Regional Heart Study, mean (standard deviation) age 78. Read More

    Initial level and rate of change in grip strength predict all-cause mortality in very old adults.
    Age Ageing 2017 May 25:1-6. Epub 2017 May 25.
    AGE Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
    Objective: to investigate the associations between initial level and rate of change in grip strength (GS) and all-cause mortality in very old adults (≥85 years) over a 9.6-year follow-up.

    Methods: prospective mortality data from 845 participants in the Newcastle 85+ Study were analysed for survival in relation to GS (kg, baseline and 5-year mean change) using Cox proportional hazards models. Read More

    Grip strength and inflammatory biomarker profiles in very old adults.
    Age Ageing 2017 May 25:1-6. Epub 2017 May 25.
    Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
    Background: weak grip strength (GS) and chronic inflammation have been implicated in the aetiology of sarcopenia in older adults. Given the interrelationships between inflammatory biomarkers, a summary variable may provide better insight into the relationship between inflammation and muscle strength. This approach has not been investigated in very old adults (aged ≥85) who are at highest risk of muscle weakness. Read More

    Identifying frailty in the Emergency Department-feasibility study.
    Age Ageing 2017 Sep;46(5):840-845
    Department of Health Sciences, University of Leicester School of Medicine, Room 3.37, Centre for Medicine, University of Leicester, Lancaster Road, Leicester LE1 7HA, UK.
    Introduction: identifying the most at risk older people in Emergency Departments (EDs) may help guide clinical practice, and service improvement in emergency care, but little is known about how to implement such tools in practice.

    Methods: consensus building was used to determine the desirable characteristics of a risk stratification process, including focus groups and literature reviewing. Candidate tools were tested using clinical vignettes in semi-structured interviews with a range of clinicians working in one large ED, assessing speed of use, ease of use and agreement with clinical judgement. Read More

    A systematic review and meta-analysis of prospective associations between alcohol consumption and incident frailty.
    Age Ageing 2017 May 25:1-9. Epub 2017 May 25.
    Department of Primary Care and Population Health, University College London, London, UK.
    Background: light-to-moderate alcohol consumption is protective against all-cause mortality and cardiovascular diseases. There is limited evidence in the literature on how alcohol consumption is related to frailty.

    Methods: five databases (Embase, Scopus, MEDLINE, CINAHL, PsycINFO) were systematically searched in July 2016 for prospective studies published between 2000 and 2016 examining baseline alcohol consumption and subsequent frailty risk among middle-aged or older community-dwelling population. Read More

    Motor function and incident dementia: a systematic review and meta-analysis.
    Age Ageing 2017 Sep;46(5):729-738
    The University of Western Ontario - Schulich School of Medicine and Dentistry, Department of Epidemiology and Biostatistics, London, Ontario, Canada.
    Background: cognitive and mobility decline are interrelated processes, whereby mobility decline coincides or precedes the onset of cognitive decline.

    Objective: to assess whether there is an association between performance on motor function tests and incident dementia.

    Methods: electronic database, grey literature and hand searching identified studies testing for associations between baseline motor function and incident dementia in older adults. Read More

    The oral health status of older patients in acute care on admission and Day 7 in two Australian hospitals.
    Age Ageing 2017 Sep;46(5):852-856
    Concord Hospital - Centre for Education and Research on Ageing, Sydney, New South Wales, Australia.
    Objective: to determine the oral health status of older patients in acute care wards at admission and after 7 days.

    Methods: a prospective descriptive study was conducted in two acute tertiary referral hospitals in New South Wales, Australia. Oral health was assessed on admission (within 24 h) and Day 7 using the Oral Health Assessment Tool. Read More

    Frailty status at admission to hospital predicts multiple adverse outcomes.
    Age Ageing 2017 Sep;46(5):801-806
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
    Aims: frailty is proposed as a summative measure of health status and marker of individual vulnerability. We aimed to investigate the discriminative capacity of a frailty index (FI) derived from interRAI Comprehensive Geriatric Assessment for Acute Care (AC) in relation to multiple adverse inpatient outcomes.

    Methods: in this prospective cohort study, an FI was derived for 1,418 patients ≥70 years across 11 hospitals in Australia. Read More

    Increased postural sway during quiet stance as a risk factor for prospective falls in community-dwelling elderly individuals.
    Age Ageing 2017 May 22:1-6. Epub 2017 May 22.
    Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
    Objective: fall-related injuries constitute major health risks in older individuals, and these risks are projected to increase in parallel with increasing human longevity. Impaired postural stability is a potential risk factor related to falls, although the evidence is inconclusive, partly due to the lack of prospective studies. This study aimed to investigate how objective measures of postural sway predict incident falls. Read More

    Public knowledge and understanding of dementia-evidence from a national survey in Ireland.
    Age Ageing 2017 Sep;46(5):865-869
    NEIL Research Programme, Trinity College Institute of Neuroscience, Dublin 2, Ireland.
    Background: there is growing consensus around the importance of population level approaches which seek to improve public knowledge and awareness of dementia.

    Aim: to assess knowledge of the relationship between dementia and ageing, and of the risk and protective factors associated with it, among the general public in Ireland.

    Design: cross-sectional survey. Read More

    Sources of unsafe primary care for older adults: a mixed-methods analysis of patient safety incident reports.
    Age Ageing 2017 Sep;46(5):833-839
    Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, Wales, UK.
    Background: older adults are frequent users of primary healthcare services, but are at increased risk of healthcare-related harm in this setting.

    Objectives: to describe the factors associated with actual or potential harm to patients aged 65 years and older, treated in primary care, to identify action to produce safer care.

    Design And Setting: a cross-sectional mixed-methods analysis of a national (England and Wales) database of patient safety incident reports from 2005 to 2013. Read More

    Nurse interventions to improve medication adherence among discharged older adults: a systematic review.
    Age Ageing 2017 Sep;46(5):747-754
    La Source, School of Nursing Sciences, University of Applied Sciences Western Switzerland, Lausanne, Switzerland.
    Background: discharged older adult inpatients are often prescribed numerous medications. However, they only take about half of their medications and many stop treatments entirely. Nurse interventions could improve medication adherence among this population. Read More

    Evidence for strategies that improve recruitment and retention of adults aged 65 years and over in randomised trials and observational studies: a systematic review.
    Age Ageing 2017 May 8:1-9. Epub 2017 May 8.
    Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK.
    Background: adults aged ≥65 years are often excluded from health research studies. Lack of representation reduces generalisability of treatments for this age group.

    Objective: to evaluate the effectiveness of strategies that improve recruitment and retention of adults aged ≥65 in observational studies and randomised controlled trials (RCTs). Read More

    Changes in time spent walking and the risk of incident dementia in older Japanese people: the Ohsaki Cohort 2006 Study.
    Age Ageing 2017 Sep;46(5):857-860
    Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
    Background: the impact of long-term changes in physical activity during adulthood in the context of primary prevention of dementia has not been addressed previously.

    Objective: to study the relationship between changes in time spent walking after middle age and incident dementia in older Japanese individuals.

    Methodology: we conducted a cohort study of 6,909 disability-free Japanese individuals aged ≥65 years who lived in Ohsaki City, Japan. Read More

    Factors related to medical students' and doctors' attitudes towards older patients: a systematic review.
    Age Ageing 2017 May 2:1-9. Epub 2017 May 2.
    Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, United Kingdom of Great Britain and Northern Ireland.
    Background: studies have sought to identify the possible determinants of medical students' and doctors' attitudes towards older patients by examining relationships with a variety of factors: demographic, educational/training, exposure to older people, personality/cognitive and job/career factors. This review collates and synthesises these findings.

    Methods: an electronic search of 10 databases was performed (ABI/Inform, ASSIA, British Nursing Index, CINAHL, Informa Health, Medline, PsycINFO, Science Direct, Scopus, and Web of Science) through to 7 February 2017. Read More

    Acupressure for frail older people in community dwellings-a randomised controlled trial.
    Age Ageing 2017 May 2:1-8. Epub 2017 May 2.
    School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
    Background: 'Frailty' is being increasing recognised as a geriatric syndrome of growing importance in the medical field. Acupressure is a non-pharmacological, non-invasive Traditional Chinese Medicine (TCM) treatment, which may serve to improve the quality of life (QOL) or prevent the progressive advancement of frailty in the aged population.

    Objective: to investigate the effects of a 12-week, TCM-principle guided acupressure intervention on the QOL of the frail older people living in the community. Read More

    Describing the participants in a study.
    Age Ageing 2017 Jul;46(4):576-581
    Medical Statistics Group, University of Southampton, Southampton, UK.
    This paper reviews the use of descriptive statistics to describe the participants included in a study. It discusses the practicalities of incorporating statistics in papers for publication in Age and Aging, concisely and in ways that are easy for readers to understand and interpret. Read More

    Rivaroxaban withdrawal and rebound hypercoagulability leading to upper extremity deep vein thrombosis: a case report.
    Age Ageing 2017 Sep;46(5):870-871
    Changi General Hospital, Singapore, Singapore.
    As the newer oral anticoagulants (NOACs) are increasingly used in older patients, clinical scenarios when they may need to be discontinued temporarily or indefinitely, may be encountered. Similarly with increasing use of permanent pacemakers and other intra-cardiac devices, there is an increased risk of upper limb venous thrombosis even few years after their insertion. We report a case of a patient with a permanent pacemaker, on rivaroxaban (NOAC) for atrial fibrillation, who developed an upper extremity deep vein thrombosis after its temporary withdrawal following a traumatic acute subdural haematoma. Read More

    Predicting discharge to institutional long-term care following acute hospitalisation: a systematic review and meta-analysis.
    Age Ageing 2017 Jul;46(4):547-558
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
    Background: moving into long-term institutional care is a significant life event for any individual. Predictors of institutional care admission from community-dwellers and people with dementia have been described, but those from the acute hospital setting have not been systematically reviewed. Our aim was to establish predictive factors for discharge to institutional care following acute hospitalisation. Read More

    Development and evaluation of the medication-based index of physical function (MedIP).
    Age Ageing 2017 Sep;46(5):761-766
    Department of Pharmaceutical Sciences, Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN, USA.
    Background: the development of an objective and comprehensive drug-based index of physical function for older adults has the potential to more accurately predict fall risk.

    Design: the index was developed using 862 adults (ages 57-85) from the National Social Life, Health, and Aging Project (NSHAP) Wave 1 study. The index was evaluated in 70 adults (ages 51-88) from a rehabilitation study of dizziness and balance. Read More

    Effectiveness of in-hospital geriatric co-management: a systematic review and meta-analysis.
    Age Ageing 2017 Apr 24:1-8. Epub 2017 Apr 24.
    Department of Public Health and Primary Care, KU Leuven - University of Leuven, Leuven, Belgium.
    Background: geriatric consultation teams have failed to impact clinical outcomes prompting geriatric co-management programmes to emerge as a promising strategy to manage frail patients on non-geriatric wards.

    Objective: to conduct a systematic review of the effectiveness of in-hospital geriatric co-management.

    Data Sources: MEDLINE, EMBASE, CINAHL and CENTRAL were searched from inception to 6 May 2016. Read More

    Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer's disease: a Phase II multicenter randomised controlled trial.
    Age Ageing 2017 Sep;46(5):767-773
    Department of Health Statistics, The Second Military Medical University, Shanghai, China.
    Background: inhibition of acetylcholinesterase (AChE) has been a effective treatment for Alzheimer's disease (AD). Octohydroaminoacridine, a new AChE inhibitor, is a potential treatment for AD.

    Method: we conducted a multicenter, randomised, double blind, placebo-controlled, parallel-group Phase II clinical trial to investigate the effects of octohydroaminoacridine in patients with mild-to-moderate AD. Read More

    Changes over time in the health and functioning of older people moving into care homes: analysis of data from the English Longitudinal Study of Ageing.
    Age Ageing 2017 Jul;46(4):693-696
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
    Background: the number of people requiring care home support is projected to rise in future years, but little information is available on the needs of new care home residents.

    Objective: to measure the health and functioning of people moving into care homes and how they have changed between 2002 and 2015.

    Setting: English Longitudinal Study of Ageing. Read More

    Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study.
    Age Ageing 2017 Mar;46(2):250-257
    Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
    Background/objective: studies on the association of dementia with specific body composition (BC) components are scarce. Our aim was to investigate associations of BC measures with different levels of cognitive function in late-life.

    Methods: we studied 5,169 participants (mean age 76 years, 42. Read More

    A multidisciplinary intervention to prevent subsequent falls and health service use following fall-related paramedic care: a randomised controlled trial.
    Age Ageing 2017 Mar;46(2):200-207
    Neuroscience Research Australia, Randwick, New South Wales, Australia.
    Background: approximately 25% of older people who fall and receive paramedic care are not subsequently transported to an emergency department (ED). These people are at high risk of future falls, unplanned healthcare use and poor health outcomes.

    Objective: to evaluate the impact of a fall-risk assessment and tailored fall prevention interventions among older community-dwellers not transported to ED following a fall on subsequent falls and health service use. Read More

    Timed Up and Go predicts functional decline in older patients presenting to the emergency department following minor trauma†.
    Age Ageing 2017 Mar;46(2):214-218
    Université Laval, Québec City, Québec, Canada.
    Background: there is no standardised test for assessing mobility in the Emergency Department (ED).

    Objective: we wished to evaluate the relationship between the Timed Up and Go (TUG) and frailty, functional decline and falls in community dwelling elders that present to the ED following minor trauma.

    Methods: this was a secondary analysis of a prospective cohort study conducted at eight Canadian hospitals. Read More

    The relationship between depression and executive function and the impact of vascular disease burden in younger and older adults.
    Age Ageing 2017 Jul;46(4):697-701
    University of Groningen, University Medical Center Groningen, Interdisciplinary Center for Psychopathology of Emotion regulation (ICPE), Groningen, The Netherlands.
    Background: depression is associated with worse executive function, but underlying mechanisms might differ by age.

    Aims: to investigate whether vascular disease burden affects the association between depression and executive dysfunction differentially by age.

    Method: among 83,613 participants of Lifelines (population-based cohort study), linear regression analyses were applied to examine the association between executive function (Ruff Figural Fluency test, dependent variable) and depression according to DSM-IV criteria (Mini International Neuropsychiatric Interview, independent variable). Read More

    Observational cohort study examining apolipoprotein E status and preoperative neuropsychological performance as predictors of post-operative delirium in an older elective arthroplasty population.
    Age Ageing 2017 Sep;46(5):779-786
    Centre for Public Health, Institute of Clinical Sciences, Block B, Queens University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UK.
    Introduction: delirium following surgery is common and is associated with negative outcomes. Preoperative cognitive impairment has been shown to be a risk factor for post-operative delirium. Often the cognitive tests used are cumbersome. Read More

    Lower likelihood of falling at age 90+ is associated with daily exercise a quarter of a century earlier: The 90+ Study.
    Age Ageing 2017 Mar 21:1-6. Epub 2017 Mar 21.
    University of California Irvine - Neurology, Irvine, California, United States.
    Objective: to explore the relationship between risk of falling at age 90+ and prior physical activity at age 60-70s.

    Design: population-based cohort study (The 90+ Study).

    Setting: California retirement community. Read More

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