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Left Ventricular End-Systolic Volume Can Predict 1-Year Hierarchical Clinical Composite End Point in Patients with Cardiac Resynchronization Therapy.

Yonsei Med J 2019 Jan;60(1):48-55

Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: This study aimed to elucidate which echocardiographic criteria at three time points, for cardiac resynchronization therapy (CRT) response, are accurate in discriminating the hierarchical clinical composite end point (HCCEP).

Materials And Methods: We included 120 patients (age, 66.1±12. Read More

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January 2019

Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review.

Yonsei Med J 2019 Jan;60(1):10-21

Division of Rheumatology, Department of Internal Medicine, and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of systemic necrotising vasculitides, which often involve small vessels, and which lead to few or no immune deposits in affected organs. According to clinical manifestations and pathological features, AAV is classified into three variants: microscopic polyangiitis, granulomatosis with polyangiitis (GPA), and eosinophilic GPA. The American College of Rheumatology 1990 criteria contributed to the classification of AAV, although currently the algorithm suggested by the European Medicines Agency in 2007 and the Chapel Hill Consensus Conference Nomenclature of Vasculitides proposed in 2012 have encouraged physicians to classify AAV patients properly. Read More

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January 2019
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Mortality Trends of Liver Diseases from 1981 to 2016 and the Projection to 2035 in Taiwan: An Age-Period-Cohort Analysis.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Background: Projections on liver diseases mortality can provide a basis for evaluating the World Health Organization's "25 by 25" goal and can help health care systems design appropriate control strategies. This study evaluated whether the 25 by 25 goal can be achieved in Taiwan and discussed possible future control strategies.

Methods: Age-period-cohort models are used to estimate the mortality trends of liver diseases from 1981 to 2016 and project these trends to 2035. Read More

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December 2018

Serum adipocyte fatty acid-binding protein levels: an indicator of non-alcoholic fatty liver disease in Chinese individuals.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.

Background & Aims: Serum adipocyte fatty acid-binding protein (A-FABP) is closely correlated to metabolic disorders such as obesity and insulin resistance (IR). Non-alcoholic fatty liver disease (NAFLD) is a typical feature of IR in the liver. The aim of this study was to explore the relationship between serum A-FABP levels and NAFLD. Read More

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December 2018

Movement Segmentation and Visual Perturbation Increase Developmental Differences in Motor Control and Learning.

Dev Sci 2018 Dec 16:e12789. Epub 2018 Dec 16.

Laboratory of Neuromotor Control and Learning, Shenzhen University, Shenzhen, 518060, P.R. China.

We examined the developmental differences in motor control and learning of a two-segment movement. One hundred and five participants (53 female) were divided into three age groups (7 to 8 years, 9 to 10 years and 19 to 27 years). They performed a two-segment movement task in four conditions (full vision, fully disturbed vision, disturbed vision in the first movement segment and disturbed vision in the second movement segment). Read More

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December 2018

The Overlooked Aspect of Excitotoxicity: Glutamate-Independent Excitotoxicity in Traumatic Brain Injuries.

Eur J Neurosci 2018 Dec 16. Epub 2018 Dec 16.

Department of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada.

Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and individuals under 45 year age. A wide variety of cellular and molecular mechanisms have been identified contributing to the pathogenesis of TBI. A better understanding of the pathophysiology behind TBI is essential for providing more effective treatment. Read More

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December 2018

A Survey on the Prevalence and Risk Indicators of Erosive Tooth Wear among Adolescents in Guangzhou, South China.

J Oral Rehabil 2018 Dec 16. Epub 2018 Dec 16.

Southern Medical University, Savaid Medical School, University of the Chinese Academy of Sciences.

Background: Erosive tooth wear (ETW) has become a crucial oral health problem over the decades in China.

Objectives: To explore the prevalence and risk indicators of ETW among adolescents in Guangzhou, south China.

Methods: A cross-sectional survey of 720 participants was conducted in Guangzhou, using an equal-sized, stratified, multistage random sampling approach. Read More

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December 2018

Association between Family History of Colorectal Cancer and the Risk of Metachronous Colorectal Neoplasia Following Polypectomy in Patients Aged <50 Years.

J Gastroenterol Hepatol 2018 Dec 16. Epub 2018 Dec 16.

Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background And Aim: The relationship between a family history of colorectal cancer (CRC) and the risk of metachronous colorectal neoplasia (CRN) following polypectomy remains unknown. We aimed to compare the risk of metachronous CRN according to CRC family history in groups of patients aged <50 and ≥50 years.

Methods: We studied patients who underwent ≥1 adenoma removal between 2010 and 2014 and follow-up surveillance colonoscopic examinations until 2017. Read More

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December 2018

Is malnutrition associated with postoperative complications in patients with primary bone sarcomas?

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: Modifiable risk factors that can be optimized to minimize postoperative complications in patients with bone sarcomas are yet to be identified.

Methods: We retrospectively identified 275 patients aged 18 and older who underwent surgery for primary bone sarcomas who also had albumin values recorded within 4 weeks before surgery. Postoperative complications were defined as infection, hematoma, need for additional surgery, or wound complications. Read More

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December 2018

From Endogenous Compounds as Biomarkers to Plasma-Derived Nanovesicles as Liquid Biopsy; Has the Golden Age of Translational PK-ADME-DDI Science Finally Arrived?

Clin Pharmacol Ther 2018 Dec 16. Epub 2018 Dec 16.

College of Medicine and Public Health, Flinders University, Adelaide, Australia.

It is now established that a drug's pharmacokinetics-absorption-distribution-metabolism-excretion-drug-drug interaction (PK-ADME-DDI) profile can be modulated by age, disease, and genotype. In order to facilitate subject phenotyping and clinical DDI assessment, therefore, various endogenous compounds (in plasma and urine) have been pursued as drug-metabolizing enzyme and transporter biomarkers. Compared to biomarkers, however, the topic of circulating extracellular vesicles as "liquid biopsy" has received little attention within the ADME community; most organs secrete nanovesicles (e. Read More

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December 2018

The role of robotic aortic lymphadenectomy in gynecological cancer: surgical and oncological outcome in a single institution experience.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

Division of Gynecologic Oncology, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background And Objective: This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients.

Methods: Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, including transperitoneal AL, between December 2014 and February 2018 at the Catholic University of the Sacred Heart, Rome, Italy.

Results: Median age of the sample population was 50 years (range, 26-76 years). Read More

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December 2018

Elevated levels of serum nitrite and nitrate, NOx, are associated with increased total and cardiovascular mortality in an 8-year follow-up study.

Eur J Clin Invest 2018 Dec 16:e13061. Epub 2018 Dec 16.

National Medical Research Center for Preventive Medicine of the Ministry of Healthcare of Russian Federation, 10 Petroverigsky per., Building 3, Moscow, 101990, Russia.

Background: Nitric oxide (NO) is one of the key regulators of vascular function. Abnormal NO signaling is linked to various cardiovascular diseases. We studied associations between circulating levels of nitric oxide metabolites, nitrite and nitrate (NOx), and total and cardiovascular mortality in a prospective 8-year follow-up cohort study in 1869 patients aged over 55 years. Read More

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December 2018

Iterative cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: A multi-institutional experience.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

St. George Hospital & University of New South Wales, Department of Surgery, Sydney, NSW, Australia.

Background And Objectives: The aims of this multi-institutional study were to assess the feasibility of iterative cytoreductive surgery (iCRS)/hyperthermic intraperitoneal chemotherapy, iCRS in colorectal peritoneal carcinomatosis (CRPC), evaluate survival, recurrence, morbidity and mortality outcomes, and identify prognostic factors for overall survival.

Methods: Patients with CRPC that underwent an iCRS, with or without intraperitoneal chemotherapy, from June 1993 to July 2016 at 13 institutions were retrospectively analyzed from prospectively maintained databases.

Results: The study comprised of 231 patients, including 126 females (54. Read More

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December 2018

Infertility patients with chromosome inversions are not susceptible to an inter-chromosomal effect.

J Assist Reprod Genet 2018 Dec 15. Epub 2018 Dec 15.

Colorado Center for Reproductive Medicine, 10290 RidgeGate Circle, Lone Tree, CO, 80124, USA.

Purpose: The aim of this study was to evaluate the incidence of an inter-chromosomal effect (ICE) in blastocyst-stage embryos from carriers of balanced chromosome inversions.

Methods: Infertility patients (n = 52) with balanced inversions (n = 66 cycles), and maternal age-matched controls that concurrently cycled (n = 66), consented to an IVF cycle with preimplantation genetic testing for aneuploidy (PGT-A). Blastocyst-stage embryos underwent trophectoderm biopsy for PGT-A with only euploid blastocysts transferred in a subsequent frozen embryo transfer. Read More

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December 2018

The effects of a 12-week jump rope exercise program on abdominal adiposity, vasoactive substances, inflammation, and vascular function in adolescent girls with prehypertension.

Eur J Appl Physiol 2018 Dec 15. Epub 2018 Dec 15.

Department of Physical Education, Pusan National University, Busan, South Korea.

Introduction: Childhood obesity is strongly associated with cardiovascular disease (CVD) development. It is necessary to combat unfavorable outcomes of obesity at a young age by utilizing effective interventions, such as exercise.

Purpose: We sought to examine the effects of a jump rope exercise program on CVD risk factors, including body composition, vasoactive substances, inflammation, and vascular function in prehypertensive adolescent girls. Read More

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December 2018
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Salivary Nickel and Chromium Levels in Orthodontic Patients with and Without Periodontitis: a Preliminary Historical Cohort Study.

Biol Trace Elem Res 2018 Dec 15. Epub 2018 Dec 15.

Pharmaceutical Chemistry, North Branch, Islamic Azad University, Tehran, Iran.

Many periodontal patients may need orthodontic treatment. Alterations in oral environment particularly the reduction of pH in periodontal patients could affect metal ion release from orthodontic appliances. However, there is no study on metal ion release in periodontal patients. Read More

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December 2018

Epidemiology of gastrostomy insertion for children and adolescents with intellectual disability.

Eur J Pediatr 2018 Dec 15. Epub 2018 Dec 15.

Telethon Kids Institute, Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, Western Australia, 6872, Australia.

The largest group of recipients of pediatric gastrostomy have neurological impairment with intellectual disability (ID). This study investigated trends in first gastrostomy insertion according to markers of disadvantage and ID etiology. Linked administrative and health data collected over a 32-year study period (1983-2014) for children with ID born between 1983 and 2009 in Western Australia were examined. Read More

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December 2018

Neurocognitive and functional outcomes at 5 years of age after renal transplant in early childhood.

Pediatr Nephrol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, Edmonton Clinic Health Academy, University of Alberta, 11405 - 87 Ave, Edmonton, AB, T6G 1C9, Canada.

Background: Clinicians often use information about developmental outcomes in decision-making around offering complex, life-saving interventions in children such as dialysis and renal transplant. This information in children with end-stage renal disease (ESRD) is limited, particularly when ESRD onset is in infancy or early childhood.

Methods: Using data from an ongoing prospective, longitudinal, inception cohort study of children with renal transplant before 5 years of age, we evaluated (1) the risk of adverse neurocognitive and functional outcomes at 5 years of age and (2) predictors of developmental outcomes. Read More

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December 2018

Efficacy of allergen-blocker mechanical barrier gel on symptoms and quality of life in patients with allergic rhinitis.

Eur Arch Otorhinolaryngol 2018 Dec 15. Epub 2018 Dec 15.

Division of Pediatric Immunology and Allergy, Dokuz Eylul University, Izmir, Turkey.

Propose: Allergic rhinitis (AR) is a very common, chronic and global health problem. In the last two decades, the efficiency of barrier-enforcing measures in AR has been investigated. In this study, we aimed to evaluate the effect of allergen-blocker mechanical barrier gel (MBG) (AlerjiSTOP) treatment on symptoms and quality of life score (QoLS) in patients with seasonal and perennial allergic rhinitis. Read More

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December 2018
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Updated Sniffin' Sticks normative data based on an extended sample of 9139 subjects.

Eur Arch Otorhinolaryngol 2018 Dec 15. Epub 2018 Dec 15.

Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.

Purpose: To provide up-to-date and detailed normative data based on a large-scale sample, increasing diagnostic validity by reference to narrow age groups as previous normative values were based upon smaller sample sizes-especially in the group of older subjects.

Method: Data were obtained from 9139 healthy subjects (4928 females aged 5-96 years and 4211 males aged 5-91 years). The standard "Sniffin' Sticks" test was applied, comprising threshold (T), discrimination (D) and identification (I) subtests, and yielding a TDI sum score. Read More

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December 2018
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Autism in India: a case-control study to understand the association between socio-economic and environmental risk factors.

Acta Neurol Belg 2018 Dec 15. Epub 2018 Dec 15.

Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, 641 046, India.

Autism spectrum disorder is a neurodevelopmental disorder and the cause of autism is still unclear. The aim of this study was to investigate the association of socioeconomic, environmental, pregnancy and newborn-related risk factors among children with autism spectrum disorders. This was a population-based case-control study. Read More

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December 2018

Dietary Patterns and Anthropometric Measures of Indian Children with Autism Spectrum Disorder.

J Autism Dev Disord 2018 Dec 15. Epub 2018 Dec 15.

Department of Studies in Food Science and Nutrition, University of Mysore, Mysuru, India.

Research literature on dietary patterns & eating habits of children with Autism Spectrum Disorder (ASD) in India is limited. To explore this, a pilot study (n = 53) which included 45 boys and 8 girls (age group of 2-13 years) was conducted. Three day food records, Food Frequency Questionnaire and Children Eating Behavior Inventory were used to assess the dietary intakes and mealtime behavior problems respectively. Read More

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December 2018

Idiopathic Pulmonary Fibrosis for Cardiologists: Differential Diagnosis, Cardiovascular Comorbidities, and Patient Management.

Adv Ther 2018 Dec 15. Epub 2018 Dec 15.

U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria - Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe - MultiMedica IRCCS, Milan, Italy.

The presence of rare comorbidities in patients with cardiovascular disease (CVD) presents a diagnostic challenge to cardiologists. In evaluating these patients, cardiologists are faced with a unique opportunity to shorten diagnosis times and direct patients towards correct treatment pathways. Idiopathic pulmonary fibrosis (IPF), a type of interstitial lung disease (ILD), is an example of a rare disease where patients frequently demonstrate comorbid CVD. Read More

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December 2018

Deep sequencing salivary proteins for periodontitis using proteomics.

Clin Oral Investig 2018 Dec 15. Epub 2018 Dec 15.

Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Objectives: Saliva is a bodily fluid transuded from gingival crevice fluid and blood and contains many proteins. Proteins in saliva have been studied as markers for periodontal diseases. Mass spectrometric analysis is applied to investigate biomarker proteins that are related to periodontitis. Read More

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December 2018

Young adult e-cigarette users: perceptions of stress, body image, and weight control.

Eat Weight Disord 2018 Dec 15. Epub 2018 Dec 15.

Westat Cancer Prevention and Control Program, Georgetown University Medical Center, 1600 Research Boulevard, Rockville, MD, 20850-3129, USA.

Objective: With the rise in electronic cigarette (ENDS) use among US young adults, more research is needed on expectations for use and perceptions related to body image, weight control, and stress relief.

Methods: College students (N = 230; modal age 21 years; 68% female) completed an online survey assessing cigarette smoking and ENDS, dieting and body image, perceptions about flavors, stress, weight gain prevention, and appetite regulation.

Sample Characteristics: Dual use (cigarette and ENDS) was reported by n = 69 (30. Read More

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December 2018

Association between REM sleep and obstructive sleep apnea in obese and overweight adolescents.

Sleep Breath 2018 Dec 15. Epub 2018 Dec 15.

Children's Hospital Los Angeles, 4650 Sunset Blvd., #83, Los Angeles, CA, USA.

Purpose: Overweight and obese children have demonstrated reduced rapid eye movement (REM) sleep, affecting energy balance regulation and predisposition to weight gain. Obstructive sleep apnea (OSA) is a known cause of decreased REM sleep. The purpose of this study is to examine the association between the percentage of REM sleep, BMI z-score, and OSA severity in overweight and obese adolescents. Read More

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December 2018

Residential Mobility and Flourishing Among United States School-Age Children, 2011/2012 National Survey of Children's Health.

Matern Child Health J 2018 Dec 15. Epub 2018 Dec 15.

Hassenfeld Child Health Innovation Institute, Brown University School of Public Health, Providence, USA.

Objectives To investigate the association of residential mobility with flourishing among school-age children. Methods Data from the 2011/2012 National Survey of Children's Health were used to examine parent/caregiver-reported information on flourishing and residential mobility for children age 6-17 (N = 63,333). Residential mobility was the number of times the child moved categorized as: none, 1-2, and 3+. Read More

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December 2018

Religiosity and Beliefs About the Transmission of Cancer, Chemotherapy, and Radiation Through Physical Contact in Saudi Arabia.

J Relig Health 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychiatry, King Abdulaziz University, Jeddah, Saudi Arabia.

We examined relationships between religiosity and Saudi cancer patients' beliefs about the spread of cancer, chemotherapy, and radiation therapy through close physical contact. Surveyed were 64 patients seen in university oncology clinics. Assessed were beliefs about the spread of cancer and its treatments, along with religious, demographic, social, psychological, and cancer-related characteristics. Read More

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December 2018

College Students' Perception of Current and Projected 30-Year Cardiovascular Disease Risk Using Cluster Analysis with Internal Validation.

Authors:
Dieu-My T Tran

J Community Health 2018 Dec 15. Epub 2018 Dec 15.

School of Nursing, University of Nevada, Las Vegas, 4505 S. Maryland Pkwy, Box 453018, Las Vegas, NV, 89154-3018, USA.

Cardiovascular risk factors in young adults at a national level are less than ideal specifically for hypercholesterolemia, hypertension, and diabetes. Explore college students' perception of their 30-year cardiovascular disease (CVD) risk using cluster analysis technique with internal validation. This is a descriptive and cross-sectional study. Read More

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December 2018
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Treatment failure of syringomyelia associated with Chiari I malformation following foramen magnum decompression: how should we proceed?

Neurosurg Rev 2018 Dec 15. Epub 2018 Dec 15.

Departments of Neurosurgery and Pediatric Neurosurgery, Tel-Aviv Medical Center and Dana Children's Hospital Tel Aviv, Tel Aviv University, 6 Weizmann Street, Tel Aviv, Israel.

The preferred treatment of patients with persistent, recurrent, or progressive syringomyelia after foramen magnum decompression (FMD) for Chiari I (CMI)-associated syringomyelia is controversial, and may include redo FMD, stabilization, or shunting procedures (such as syringopleural or syringo-subarachnoid shunts). We describe our experience in treating these patients and discuss the treatment modalities for these patients. We retrospectively collected data of CMI patients with persistent, recurrent, or progressive syringomyelia after FMD. Read More

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December 2018

Association between glycemic control, age, and outcomes among intensively treated patients with acute myeloid leukemia.

Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.

Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.

Purpose: To investigate the impact of hyperglycemia and glycemic variability during intensive acute myeloid leukemia therapy (AML) on outcomes by age.

Methods: Retrospective study of 262 consecutive patients with newly diagnosed AML hospitalized for intensive induction. Hyperglycemia was assessed by mean blood glucose (BG) (mg/dL) during hospitalization and glycemic variability was determined by the standard deviation (SD) of mean BG. Read More

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December 2018

Variation of degree of stenosis quantification using different energy level with dual energy CT scanner.

Neuroradiology 2018 Dec 15. Epub 2018 Dec 15.

Department of Neuroimaging and Neurointervention, Stanford University Medical Center, Stanford, CA, USA.

Purpose: To investigate the variation in the quantification of the carotid degree of stenosis (DoS) with a dual energy computed tomography (CT), using different energy levels during the image reconstruction.

Methods: In this retrospective study, 53 subjects (37 males; mean age 67 ± 11 years; age range 47-83 years) studied with a multi-energy CT scanner were included. Datasets were reconstructed on a dedicated workstation and from the CT raw data multiple datasets were generated at the following monochromatic energy levels: 66, 70, 77, and 86 kilo-electronvolt (keV). Read More

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December 2018

Increased choroidal thickness: a new feature to monitor age-related macular degeneration recurrence.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 16. Epub 2018 Dec 16.

Hôpital d'Instruction des Armées Desgenettes, 108 Boulevard Pinel, 69003, Lyon, France.

Purpose: The main objective of this study was to assess choroidal thickness (CT) changes during an exudative recurrence of age-related macular degeneration (AMD).

Methods: A real-life prospective non-interventional 9-month study was conducted in two centers in consecutive patients with exudative AMD between November 2016 and July 2017. CT was measured manually in both eyes based on enhanced-depth imaging spectral-domain optical coherence tomography at different follow-up visits scheduled in the morning. Read More

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December 2018

Effects of posterior scleral reinforcement in pathological myopia: a 3-year follow-up study.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 15. Epub 2018 Dec 15.

Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Laboratory of Lens Research of Liaoning Province, Shenyang, China.

Purpose: To assess the effects of posterior sclera reinforcement (PSR) in refractive outcomes, choroidal thickness (CT), and retinal thickness (RT) during a 3-year follow-up in eyes with pathological myopia.

Methods: Thirty-eight eyes of 26 adults with pathological myopia who underwent PSR (the PSR group) and 30 eyes of 18 adults with matched age and myopia who did not receive PSR treatment (the control group) were followed up with measurements of axial length (AL), spherical equivalent (SE), best corrected visual acuity (BCVA), CT, and RT at baseline, 1 and 3 months, and 1, 2, and 3 years postoperatively. Data were analyzed by repeated measures analysis of variance and independent-samples t test. Read More

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December 2018

Histological dating of subdural hematoma in infants.

Int J Legal Med 2018 Dec 15. Epub 2018 Dec 15.

Forensic Department, APHM, La Timone, 264 rue St Pierre, 13385, Marseille, Cedex 05, France.

Background: After infant deaths due to non-accidental head injury (NAHI) with subdural hematoma (SDH), the magistrates ask experts to date the traumatic event. To do so, the expert only has tools based on adult series of NAHI. We aimed to develop an SDH dating system applicable to infants aged under 3 years. Read More

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December 2018

Neurocognitive, academic and functional outcomes in survivors of infant ependymoma (UKCCSG CNS 9204).

Childs Nerv Syst 2018 Dec 15. Epub 2018 Dec 15.

Children's Brain Tumour Research Centre, Academic Division of Child Health, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2RD, UK.

Purpose: This is the first UK multi-centre case-controlled study with follow-up in excess of 10 years to report the neurocognitive, academic and psychological outcomes of individuals diagnosed with a brain tumour in early childhood. Children enrolled into the UKCCSG CNS 9204 trial, diagnosed with intracranial ependymoma when aged ≤ 36 months old, who received a primary chemotherapy strategy to defer or avoid radiotherapy, were recruited.

Methods: Outcomes of those who relapsed and subsequently received radiotherapy (n = 13) were compared to those enrolled who did not relapse (n = 16), age-matched controls-diagnosed with solid non-central nervous system (SN-CNS; n = 15) tumours or low-grade posterior fossa pilocytic astrocytoma (PFPA; n = 15), and normative data. Read More

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December 2018

Cranioplasties following craniectomies in children-a multicenter, retrospective cohort study.

Childs Nerv Syst 2018 Dec 15. Epub 2018 Dec 15.

Department of Neurosurgery, Division of Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, room G03.124, 3484 CX, Utrecht, The Netherlands.

Objective: Complications following pediatric cranioplasty after craniectomy with either autologous bone flaps or cranial implants are reported to be common, particularly bone flap resorption. However, only sparse data are available regarding cranioplasty strategies, complications, and outcomes. This manuscript describes a Canadian-Dutch multicenter pediatric cohort study with autografts and cranial implant cranioplasties following craniectomies for a variety of indications. Read More

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December 2018

Playing Super Mario increases oculomotor inhibition and frontal eye field grey matter in older adults.

Exp Brain Res 2018 Dec 15. Epub 2018 Dec 15.

Centre de Recherche en Neuropsychologie et Cogntion, University of Montreal, Pavillon Marie-Victorin 90, Avenue Vincent d'Indy, Montreal, QC, H2V 2S9, Canada.

Aging is associated with cognitive decline and decreased capacity to inhibit distracting information. Video game training holds promise to increase inhibitory mechanisms in older adults. In the current study, we tested the impact of 3D-platform video game training on performance in an antisaccade task and on related changes in grey matter within the frontal eye fields (FEFs) of older adults. Read More

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December 2018

Promotion of the mediterranean diet incancer long-survivors by means of the Med-Food Anticancer Program: a pilot study.

Ann Ig 2019 Jan-Feb;31(1):45-51

Discipline of Nutrition and Dietetics, The University of Auckland, New Zealand.

Background: The intervention "Med-Anticancer Food Program" has proven to be effective in promoting the Mediterranean Diet, significantly increasing the Mediterranean Adequacy Index in healthy subjects. There are no studies that have investigated the effectiveness of this intervention in individuals who have had a diagnosis of cancer.

Objective: To perform a pilot study to assess the opportunity of employing the methodology of the Med-Anticancer Food Program in order to encourage "long-term cancer survivors" to adhere to the Mediterranean Diet, as well as healthy people, and this in order to apply the program to larger groups. Read More

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December 2018

Health status, diseases and vaccinations of the homeless in the city of Palermo, Italy.

Ann Ig 2019 Jan-Feb;31(1):21-34

Department of Science for Health Promotion and Mother-Child Care "G. D'Alessandro", University of Palermo, Palermo, Italy.

Introduction: In Italy, as in the rest of the world, the number of homeless people is increasing considerably. Many of them suffer from chronic conditions, mental health problems and addiction to alcohol, drugs or smoking, and need complex medical care. Their health status is often exacerbated by greater difficulty in accessing primary care. Read More

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December 2018

Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study.

Med Sci Monit 2018 Dec 16;24:9136-9143. Epub 2018 Dec 16.

Sixth Affiliated Hospital, Kunming Medical University, Yuxi, Yunnan, China (mainland).

BACKGROUND This study aimed to investigate the relationship between serum profiles of prolactin and thyroid stimulating hormone (TSH) and sexual dysfunction in patients with schizophrenia treated with conventional antipsychotic medication. MATERIAL AND METHODS A hospital-based cross-sectional study included 118 patients, age range 18-57 years (55 men, 63 women), with a confirmed diagnosis of schizophrenia. All patients were stable after antipsychotic treatment. Read More

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December 2018

Gastric Cancer with Submucosal Invasion after Successful Helicobacter pylori Eradication: A Propensity Score-Matched Analysis of Patients with Annual Patient Endoscopic Survey.

Digestion 2018 Dec 14;99(1):59-65. Epub 2018 Dec 14.

Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan.

Background And Aim: The incidence of gastric cancer occurring after successful Helicobacter pylori eradication has been increasing. We aimed to clarify the influence of eradication therapy on the ability to diagnose early gastric cancer after successful H. pylori eradication in patients who underwent annual endoscopic screening. Read More

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December 2018

A Mediterranean Diet with an Enhanced Consumption of Extra Virgin Olive Oil and Pistachios Improves Pregnancy Outcomes in Women Without Gestational Diabetes Mellitus: A Sub-Analysis of the St. Carlos Gestational Diabetes Mellitus Prevention Study.

Ann Nutr Metab 2018 Dec 14;74(1):69-79. Epub 2018 Dec 14.

Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid,

Aims: The aim of the study was to evaluate the effect of a Mediterranean diet (MedDiet), enhanced with extra virgin olive oil (EVOO) and nuts, on a composite of adverse maternofoetal outcomes of women with normoglycemia during pregnancy.

Methods: This was a sub-analysis of the St Carlos gestational diabetes mellitus Prevention Study. Only normoglycemic women were analysed (697). Read More

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December 2018
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Is There A Relation Between Serum Uric Acid Values and Prostatic Calculi Presence?

Urol Int 2018 Dec 14:1-6. Epub 2018 Dec 14.

Department of Radiology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.

Objective: We planned to examine the connection between serum uric acid (UA) values and prostatic calculi (PCal) presence and to evaluate the relation between PCal and other etiological factors.

Methods: Patients between 20 and 60 years of age who were referred to the clinic with any reason and had non-contrast abdominal tomography (NCACT) for PCal were included in the study. While the patients were separated into 2 groups based on their serum UA level as ≥7 mg/dL (Group 1) and < 7 mg/dL (Group 2), NCACT was also divided into 2 groups as PCal presence (PCal+) and lack (PCal-) serum UA, calcium, phosphorus, sodium, prostate-specific antigen levels and urinary analysis results of the patients were evaluated and compared. Read More

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December 2018

Use of Hepatitis C Positive Organs: Patient Attitudes in Urban Chicago.

Am J Nephrol 2018 Dec 14;49(1):32-40. Epub 2018 Dec 14.

Department of Internal Medicine, Section of Gastroenterology, Hepatology, and Nutrition, The University of Chicago Medicine, Chicago, Illinois, USA.

Background: Hepatitis C virus (HCV)-infected organs are being transplanted in patients with and without HCV in the direct-acting antiviral era. Little is known about patient attitudes towards receiving an HCV-positive organ.

Objectives: The aim of this study is to determine transplant candidates' attitudes towards receiving HCV-positive organs. Read More

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December 2018

Pilot Study Indicates Helicobacter pylori Infection May Induce Small Intestinal Mucosal Injury.

Digestion 2018 Dec 14;99(1):66-71. Epub 2018 Dec 14.

Background And Aim: Helicobacter pylori infection is a primary cause of gastroduodenal ulcers. To investigate whether there is an association between H. pylori infection and small intestinal mucosal injury. Read More

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December 2018

Transbronchial Cryobiopsies for Diagnosing Interstitial Lung Disease: Real-Life Experience from a Tertiary Referral Center for Interstitial Lung Disease.

Respiration 2018 Dec 14:1-7. Epub 2018 Dec 14.

Center for Interstitial and Rare Lung Diseases, Thoraxklinik, University of Heidelberg, Heidelberg,

Background: Transbronchial cryobiopsy (cTBB) may offer an alternative to surgical lung biopsy (SLB) for histopathological diagnosis of interstitial lung diseases (ILDs). However, real-life experience is limited, although case series are increasingly reported.

Objectives: We aimed to evaluate the value of cTBB performed under real-life conditions in a tertiary care center for ILDs. Read More

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December 2018

Diagnostic Accuracy of Frailty Screening Methods in Advanced Chronic Kidney Disease.

Nephron 2018 Dec 14:1-9. Epub 2018 Dec 14.

Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom.

Background/aims: Frail patients with chronic kidney disease (CKD) have an increased hospitalisation and mortality rate. However, many popular frailty screening methods have not been validated in patients with CKD. This study evaluates the diagnostic accuracy of several frailty screening methods in patients with CKD G4-5 and those established on haemodialysis (G5D). Read More

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December 2018

Incidence of the initiation of comfort care immediately following emergent neurosurgical and endovascular procedures.

Authors:

J Neurosurg 2018 Dec 14:1-9. Epub 2018 Dec 14.

OBJECTIVEIt is unknown what proportion of patients who undergo emergent neurosurgical procedures initiate comfort care (CC) measures shortly after the operation. The purpose of the present study was to analyze the proportion and predictive factors of patients who initiated CC measures within the same hospital admission after undergoing emergent neurosurgery.METHODSThis retrospective cohort study included all adult patients who underwent emergent neurosurgical and endovascular procedures at a single center between 2009 and 2014. Read More

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December 2018

Screening and surgery for foramen magnum stenosis in children with achondroplasia: a large, national database analysis.

Authors:

J Neurosurg Pediatr 2018 Dec 14:1-7. Epub 2018 Dec 14.

OBJECTIVEThe goal of this study was to determine the rates of screening and surgery for foramen magnum stenosis in children with achondroplasia in a large, privately insured healthcare network.METHODSRates of screening and surgery for foramen magnum stenosis in children with achondroplasia were determined using de-identified insurance claims data from a large, privately insured healthcare network of over 58 million beneficiaries across the United States between 2001 and 2014. Cases of achondroplasia and screening and surgery claims were identified using a combination of International Classification of Diseases diagnosis codes and Current Procedural Terminology codes. Read More

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December 2018
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