1,028 results match your criteria Age[Journal]

GeroScience: understanding the interaction of processes of aging and chronic diseases.

Age (Dordr) 2016 12;38(5-6):377-378

University of Oklahoma Health Science Center, Oklahoma, OK, USA.

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December 2016

Basal body temperature as a biomarker of healthy aging.

Age (Dordr) 2016 Dec 26;38(5-6):445-454. Epub 2016 Oct 26.

Intramural Research Program National Institute on Aging, 3001 S. Hanover Street, 5th Floor, Baltimore, MD, 21225, USA.

Scattered evidence indicates that a lower basal body temperature may be associated with prolonged health span, yet few studies have directly evaluated this relationship. We examined cross-sectional and longitudinal associations between early morning oral temperature (95.0-98. Read More

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December 2016

Structural brain changes and all-cause mortality in the elderly population-the mediating role of inflammation.

Age (Dordr) 2016 Dec 20;38(5-6):455-464. Epub 2016 Oct 20.

Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany.

While MRI brain changes have been related to mortality during ageing, the role of inflammation in this relationship remains poorly understood. Hence, this study aimed to investigate the impact of MRI changes on all-cause mortality and the mediating role of cytokines. All-cause mortality was evaluated in 268 community dwelling elderly (age 65-83 years) in the MEMO study (Memory and Morbidity in Augsburg elderly). Read More

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December 2016

Apolipoproteins and HDL cholesterol do not associate with the risk of future dementia and Alzheimer's disease: the National Finnish population study (FINRISK).

Age (Dordr) 2016 Dec 23;38(5-6):465-473. Epub 2016 Sep 23.

National Institute for Health and Welfare, PL 30, 00271, Helsinki, Finland.

Data on associations of apolipoproteins A-I and B (apo A-I, apo B) and HDL cholesterol (HDL-C) with dementia and Alzheimer's disease (AD) are conflicting. Our aim was to examine, whether apo B, apoA-I, their ratio, or HDL-C are significant, independent predictors of incident dementia and AD in the general population free of dementia at baseline. We analyzed the results from two Finnish prospective population-based cohort studies in a total of 13,275 subjects aged 25 to 74 years with mainly Caucasian ethnicity. Read More

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December 2016

Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a.

Age (Dordr) 2016 Dec 9;38(5-6):405-418. Epub 2016 Sep 9.

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, People's Republic of China.

Age-related cognitive decline has been associated with changes in endogenous hormones and epigenetic modification of chromatin, including histone acetylation. Developmental exposure to endocrine disrupting chemicals, such as bisphenol-A (BPA) that produces endocrine disruption and epigenetic changes, may be a risk factor for accelerating cognitive deficits during aging. Thus, we exposed CD-1 mice to BPA (0, 1, and 100 mg/l BPA in the drinking water) orally during puberty (from postnatal days 28 to 56) and investigated whether pubertal BPA exposure exacerbates the age-related impairment of spatial cognition in old age (18 months old) and whether serum sex and thyroid hormones or hippocampal histone acetylation (H3K9ac and H4K8ac) are associated with cognitive effects. Read More

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December 2016

Age at menarche and age at natural menopause in East Asian women: a genome-wide association study.

Age (Dordr) 2016 Dec 14;38(5-6):513-523. Epub 2016 Sep 14.

Department of Medicine, Vanderbilt Epidemiology Center and Division of Epidemiology, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, IMPH, Nashville, Tennessee, 37203, USA.

Age at menarche (AM) and age at natural menopause (ANM) are complex traits with a high heritability. Abnormal timing of menarche or menopause is associated with a reduced span of fertility and risk for several age-related diseases including breast, endometrial and ovarian cancer, cardiovascular disease, and osteoporosis. To identify novel genetic loci for AM or ANM in East Asian women and to replicate previously identified loci primarily in women of European ancestry by genome-wide association studies (GWASs), we conducted a two-stage GWAS. Read More

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December 2016

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.

Age (Dordr) 2016 Aug 9;38(4):273-289. Epub 2016 Sep 9.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

Strong epidemiological and experimental evidence indicate that both age and hypertension lead to significant functional and structural impairment of the cerebral microcirculation, predisposing to the development of vascular cognitive impairment (VCI) and Alzheimer's disease. Preclinical studies establish a causal link between cognitive decline and microvascular rarefaction in the hippocampus, an area of brain important for learning and memory. Age-related decline in circulating IGF-1 levels results in functional impairment of the cerebral microvessels; however, the mechanistic role of IGF-1 deficiency in impaired hippocampal microvascularization remains elusive. Read More

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Combined statin and angiotensin-converting enzyme (ACE) inhibitor treatment increases the lifespan of long-lived F1 male mice.

Age (Dordr) 2016 Dec 2;38(5-6):379-391. Epub 2016 Sep 2.

Department of Statistics, University of California at Riverside, Riverside, CA, 92521, USA.

Statins, such as simvastatin, and ACE inhibitors (ACEis), such as ramipril, are standard therapies for the prevention and treatment of cardiovascular diseases. These types of drugs are commonly administered together. More recently, angiotensin II type 1 receptor (AT1R) antagonists, such as candesartan cilexetil (candesartan), have been used in the place of, or in combination with, ACEis. Read More

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December 2016

Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance.

Age (Dordr) 2016 Dec 1;38(5-6):485-493. Epub 2016 Sep 1.

Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78223, USA.

To determine the efficacy of pioglitazone to prevent type 2 diabetes in older compared to younger adults with pre-diabetes. Six hundred two participants with impaired glucose tolerance (IGT) were randomized in double blind fashion to placebo or pioglitazone for diabetes prevention in the ACT NOW study (NEJM 364:1104-1115, 2011). Cox proportional hazard regression was used to compare time to development of diabetes over a mean of 2 years between older (≥61 years) and younger participants. Read More

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December 2016

Association between rapid force production by the plantar flexors and balance performance in elderly men and women.

Age (Dordr) 2016 Dec 31;38(5-6):475-483. Epub 2016 Aug 31.

College of Systems Engineering and Science, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama-shi, Saitama, 337-8570, Japan.

Plantar flexion strength and balance ability are considered to be crucial for avoiding falls. However, no clear relationship has been established between these two factors in elderly population. This study aimed to examine the association between plantar flexion strength and balance performance in elderly men and women. Read More

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December 2016

Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice.

Age (Dordr) 2016 Aug 30;38(4):291-302. Epub 2016 Aug 30.

Department of Medicine, School of Medicine, University of California, 9500 Gilman Drive # 0702, La Jolla, San Diego, CA, 92093, USA.

We aimed to investigate whether aging increases the susceptibility of hepatic and renal inflammation or fibrosis in response to high-fat diet (HFD) and explore the underlying genetic alterations. Middle (10 months old) and old (20 months old) aged, male C57BL/6N mice were fed either a low-fat diet (4 % fat) or HFD (60 % fat) for 4 months. Young (3 months old) aged mice were included as control group. Read More

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Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats.

Age (Dordr) 2016 Dec 30;38(5-6):393-404. Epub 2016 Aug 30.

USDA-ARS, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA.

High consumption of fruits and vegetables has been associated with reduced risk of debilitating diseases and improved cognition in aged populations. These beneficial effects have been attributed to the phytochemicals found in fruits and vegetables, which have previously been shown to be anti-inflammatory and modulate autophagy. Tart cherries contain a variety of potentially beneficial phytochemicals; however, little research has been done to investigate the effects of tart cherry on the aging brain. Read More

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December 2016

Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds.

Age (Dordr) 2016 Dec 29;38(5-6):433-443. Epub 2016 Aug 29.

Department of Ecology and Evolution, Quartier Sorge, bâtiment Biophore, University of Lausanne, 1015, Lausanne, Switzerland.

Mitochondrial respiration releases reactive oxygen species (ROS) as by-products that can damage the soma and may in turn accelerate ageing. Hence, according to "the oxidative stress theory of ageing", longer-lived organisms may have evolved mechanisms that improve mitochondrial function, reduce ROS production and/or increase cell resistance to oxidative damage. Cardiolipin, an important mitochondrial inner-membrane phospholipid, has these properties by binding and stabilizing mitochondrial inner-membrane proteins. Read More

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December 2016

Age-associated vulval integrity is an important marker of nematode healthspan.

Age (Dordr) 2016 Dec 26;38(5-6):419-431. Epub 2016 Aug 26.

Department of Pathology, University of Washington, Seattle, WA, 98195, USA.

Improving healthspan, defined as the period where organisms live without frailty and/or disease, is a major goal of biomedical research. While healthspan measures in people are relatively easy to identify, developing robust markers of healthspan in model organisms has proven challenging. Studies using the nematode Caenorhabditis elegans have provided vital information on the basic mechanisms of aging; however, worm health is difficult to define, and the impact of interventions that increase lifespan on worm healthspan has been controversial. Read More

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December 2016

IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.

Age (Dordr) 2016 Aug 26;38(4):239-258. Epub 2016 Aug 26.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

Epidemiological findings support the concept of Developmental Origins of Health and Disease, suggesting that early-life hormonal influences during a sensitive period of development have a fundamental impact on vascular health later in life. The endocrine changes that occur during development are highly conserved across mammalian species and include dramatic increases in circulating IGF-1 levels during adolescence. The present study was designed to characterize the effect of developmental IGF-1 deficiency on the vascular aging phenotype. Read More

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Tinetti mobility test is related to muscle mass and strength in non-institutionalized elderly people.

Age (Dordr) 2016 Dec 26;38(5-6):525-533. Epub 2016 Aug 26.

Department of Translational Medical Sciences, University of Naples "Federico II", Via S. Pansini, 80131, Naples, Italy.

Elderly people are characterized by a high prevalence of falls and sarcopenia. However, the relationship among Tinetti mobility test (TMT) score, a powerful tool to detect elderly people at risk of falls, and sarcopenia is still not thoroughly investigated. Thus, to determine the relationship between TMT score and muscle mass and strength, 337 elderly participants (mean age 77. Read More

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December 2016

Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study.

Age (Dordr) 2016 Dec 25;38(5-6):505-512. Epub 2016 Aug 25.

Department of Biological Sciences, Northern Arizona University, PO Box 5640, Flagstaff, AZ, 86011-5640, USA.

Older individuals who exercise regularly exhibit greater resistance to oxidative stress than their sedentary peers, suggesting that exercise can modify age-associated loss of resistance to oxidative stress. However, we recently demonstrated that a single bout of exercise confers protection against a subsequent oxidative challenge in young, but not older adults. We therefore hypothesized that repeated bouts of exercise would be needed to increase resistance to an oxidative challenge in sedentary older middle-aged adults. Read More

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December 2016

Effects of the APOE ε4 allele and education on cognitive function in Japanese centenarians.

Age (Dordr) 2016 Dec 24;38(5-6):495-503. Epub 2016 Aug 24.

Center for Supercentenarian Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Apolipoprotein E (APOE) ε4 allele and education have been reported to affect the cognitive function in young-old adults. However, the effects and interactions of the ε4 allele and education on cognitive function in very old age, particularly in centenarians, are not well known. We studied 542 Japanese centenarians. Read More

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December 2016

Effects of aging on the relationship between cognitive demand and step variability during dual-task walking.

Age (Dordr) 2016 Aug 3;38(4):363-375. Epub 2016 Aug 3.

Translational Gerontology Branch, Longitudinal Studies Section, National Institute on Aging, 251 Bayview Blvd., Suite 100, Rm 04B316, Baltimore, MD, 21224, USA.

A U-shaped relationship between cognitive demand and gait control may exist in dual-task situations, reflecting opposing effects of external focus of attention and attentional resource competition. The purpose of the study was twofold: to examine whether gait control, as evaluated from step-to-step variability, is related to cognitive task difficulty in a U-shaped manner and to determine whether age modifies this relationship. Young and older adults walked on a treadmill without attentional requirement and while performing a dichotic listening task under three attention conditions: non-forced (NF), forced-right (FR), and forced-left (FL). Read More

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Computer-based tools for assessing micro-longitudinal patterns of cognitive function in older adults.

Age (Dordr) 2016 Aug 29;38(4):335-350. Epub 2016 Jul 29.

Centre for Assistive Technology and Connected Healthcare (CATCH), University of Sheffield, Sheffield, UK.

Patterns of cognitive change over micro-longitudinal timescales (i.e., ranging from hours to days) are associated with a wide range of age-related health and functional outcomes. Read More

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The effect of lengthening contractions on neuromuscular junction structure in adult and old mice.

Age (Dordr) 2016 Aug 29;38(4):259-272. Epub 2016 Jul 29.

MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L7 8TX, UK.

Skeletal muscles of old mice demonstrate a profound inability to regenerate fully following damage. Such a failure could be catastrophic to older individuals where muscle loss is already evident. Degeneration and regeneration of muscle fibres following contraction-induced injury in adult and old mice are well characterised, but little is known about the accompanying changes in motor neurons and neuromuscular junctions (NMJs) following this form of injury although defective re-innervation of muscle following contraction-induced damage has been proposed to play a role in sarcopenia. Read More

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Mitochondria and oxidative stress in heart aging.

Age (Dordr) 2016 Aug 24;38(4):225-238. Epub 2016 Jul 24.

Department of Physiology, Faculty of Medicine, Complutense University, Plaza Ramon y Cajal s/n, 28040, Madrid, Spain.

As average lifespan of humans increases in western countries, cardiac diseases become the first cause of death. Aging is among the most important risk factors that increase susceptibility for developing cardiovascular diseases. The heart has very aerobic metabolism, and is highly dependent on mitochondrial function, since mitochondria generate more than 90 % of the intracellular ATP consumed by cardiomyocytes. Read More

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Neural correlates of older adults' self-overestimation of stepping-over ability.

Age (Dordr) 2016 Aug 23;38(4):351-361. Epub 2016 Jul 23.

Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.

A growing body of literature indicates that cognitively intact older adults tend to overestimate their physical functioning (e.g., step-over ability), which may lead to fall risk. Read More

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Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle.

Age (Dordr) 2016 Aug 21;38(4):323-333. Epub 2016 Jul 21.

Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

Mitochondria contain multiple copies of the circular mitochondrial genome (mtDNA) that encodes ribosomal RNAs and proteins locally translated for oxidative phosphorylation. Loss of mtDNA integrity, both altered copy number and increased mutations, is implicated in cellular dysfunction with aging. Published data on mtDNA copy number and aging is discordant which may be due to methodological limitations for quantifying mtDNA copy number. Read More

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Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice.

Age (Dordr) 2016 Aug 21;38(4):303-322. Epub 2016 Jul 21.

Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, 211166, China.

Transgenic APPSwe/PS1dE9 (APP/PS1) mice that overproduce amyloid beta (Aβ) are extensively used in the studies of pathogenesis and experimental therapeutics and new drug screening for Alzheimer's disease (AD). However, most of the current literature uses young or adult APP/PS1 mice. In order to provide a broader view of AD-like phenotype of this animal model, in this study, we systematically analyzed behavioral and pathological profiles of 24-month-old male APP/PS1 mice. Read More

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The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies.

Age (Dordr) 2016 Jun 14;38(3):65. Epub 2016 Jun 14.

Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland.

The epigenetic clock, defined as the DNA methylome age (DNAmAge), is a candidate biomarker of ageing. In this study, we aimed to characterize the behaviour of this marker during the human lifespan in more detail using two follow-up cohorts (the Young Finns study, calendar age i.e. Read More

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Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease.

Age (Dordr) 2016 Jun 6;38(3):64. Epub 2016 Jun 6.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), 1122 N.E. 13th Street, O'Donoghue Research Building, Suite 1200, Oklahoma City, OK, 73117, USA.

The aim of the study was to determine whether gait characteristics were associated with endothelial cell inflammation, oxidative stress, and apoptosis and with circulating biomarkers of inflammation and antioxidant capacity in older patients with symptomatic peripheral artery disease (PAD). Gait measurements of 231 symptomatic men and women with PAD were assessed during a 4-m walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells and on circulating inflammatory and vascular biomarkers. Read More

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Factors producing over-selectivity in older individuals.

Age (Dordr) 2016 Jun 31;38(3):63. Epub 2016 May 31.

Department of Psychology, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.

Stimulus over-selectivity describes a phenomenon where only a subset of the relevant stimuli present in the environment, control an individual's behavior. The current experiment explored the degree to which over-selectivity increases in old age. The level of over-selectivity in a visual discrimination task in 60 individuals aged 60-89 years was assessed, as well as the degree to which this reflected attentional control. Read More

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Cristacarpin promotes ER stress-mediated ROS generation leading to premature senescence by activation of p21(waf-1).

Age (Dordr) 2016 Jun 31;38(3):62. Epub 2016 May 31.

Academy of Scientific & Innovative Research (AcSIR), New Delhi, India.

Stress-induced premature senescence (SIPS) is quite similar to replicative senescence that is committed by cells exposed to various stress conditions viz. ultraviolet radiation (DNA damage), hydrogen peroxide (oxidative stress), chemotherapeutic agents (cytotoxic threat), etc. Here, we report that cristacarpin, a natural product obtained from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering senescence in pancreatic and breast cancer cells through blocking the cell cycle in the G1 phase. Read More

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