1,655 results match your criteria African health sciences[Journal]


Interface of non-communicable diseases and infections in Africa.

Authors:
James K Tumwine

Afr Health Sci 2018 Dec;18(4):i-iv

Department of Paediatrics and Child Health, School of Medicine, Makerere University, Kampala, Uganda.

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http://dx.doi.org/10.4314/ahs.v18i4.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354889PMC
December 2018

Inhibition of cell proliferation, migration and colony formation of LS174T Cells by carbonic anhydrase inhibitor.

Afr Health Sci 2018 Dec;18(4):1303-1310

Department of Pharmaceutical Toxicology, Faculty of Pharmacy, İnönü University, Malatya, Turkey.

Background: Metastasis is the leading cause of cancer deaths. Migration of tumor cells is an important stage in metastasis. Therefore, recent studies have focused on clarifying migration and migration-dependent cell functions such as angiogenesis, wound healing, and invasion. Read More

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https://www.ajol.info/index.php/ahs/article/view/180343
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http://dx.doi.org/10.4314/ahs.v18i4.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354875PMC
December 2018
6 Reads

The immunomodulatory peptide bursopentin (BP5) enhances proliferation and induces sIgM expression in DT40 cells.

Afr Health Sci 2018 Dec;18(4):1292-1302

Division of Key Lab of Animal Disease Diagnosis and Immunology of China's Department of Agriculture, Nanjing Agriculture University, Nanjing 210095, China.

Background: In the recent past, many studies have been focused on extracts of BF and multiple biologically active factors and their effects on humoral immune system in chickens and birds. However, the mechanism of those immunomodulatory peptides on the B lineage cells proliferation and antibody production in chicken is fairly unknown. DT40 cell line, an avian leucosis virus-induced chicken pre-B cell line, expresses immunoglobulin M (IgM) isotype B cell reporter in the plasma membrane. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354878PMC
December 2018

Dose related effects of oral clonidine pre-medication on bupivacaine spinal anaesthesia.

Afr Health Sci 2018 Dec;18(4):1283-1291

Department of Anaesthesia, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin/ University of Ilorin Teaching Hospital, Ilorin, Nigeria.

Introduction: The duration of action of sub-arachnoid block is short, and one of the ways to overcome this is the use of oral clonidine.

Methods: 108 patients of ASA I and II, aged 18 to 65 years undergoing lower abdominal surgeries under spinal anaesthesia were randomized into three groups.. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354890PMC
December 2018

A comparison of risk of hypotension using standard doses of remifentanil versus dexmedetomidine infusions in adult patients undergoing surgery under general anaesthesia at the Aga Khan University Hospital, Nairobi.

Afr Health Sci 2018 Dec;18(4):1267-1282

Department of Anaesthesia, Aga Khan University, East Africa.

Background: Remifentanil and dexmedetomidine are common agents used in general anaesthesia, monitored anaesthesia care and critical care. When combined with inhaled or intravenous anaesthetic agents intra-operatively, they provide analgesia, lower general anaesthetic requirements and provide sedation and analgesia in the peri-operative period if indicated. Pharmacodynamically, they cause hypotension and bradycardia which are reversible if well managed. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354876PMC
December 2018
1 Read

Women's attitude and reasons toward justifying domestic violence in Ethiopia: a systematic review and meta-analysis.

Afr Health Sci 2018 Dec;18(4):1255-1266

University of Gondar, Nursing.

Background: Domestic violence (DV) is a global public problem that touches all levels of society and socio-economic status. Identifying women's attitudes towards domestic violence is an important first step in the prevention and control of its consequence. Thus, this systematic review and meta-analysis aimed: (i) to synthesize women's reasons for justifying domestic violence and (ii) to determine the pooled prevalence of women's attitude towards domestic violence in Ethiopia. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354873PMC
December 2018

Geophagia, nutrition and health of women with pregnancy-induced hypertension.

Afr Health Sci 2018 Dec;18(4):1243-1254

Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah. University of Science and Technology, Kumasi, Ghana.

Background: Calcium is a major nutrient implicated in pregnancy-induced hypertension (PIH). Aside dietary sources, geophagia has been reported to provide calcium needed to prevent PIH. These soils are shown to contain significant amount of heavy metals which have been associated with hypertension. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354851PMC
December 2018
0.662 Impact Factor

Exercise capacity and muscle fatiguability alterations following a progressive maximal exercise of lower extremities in children with cystic fibrosis.

Afr Health Sci 2018 Dec;18(4):1236-1242

Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.

Background: Impairment of peripheral skeletal muscle function is a common phenomenon in patients with cystic fibrosis (CF) in addition to great clinical connotations, such as lack of exercise tolerance and decrease of health-related quality of life. There is very limited data on the effects of maximal exercise on muscle fatiguability and exercise capacity in children with cystic fibrosis.

Objectives: The aim of this study was to evaluate the effect of progressive maximal exercise training of the lower extremities on exercise capacity and muscle fatiguability in children with cystic fibrosis. Read More

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https://www.ajol.info/index.php/ahs/article/view/180337
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http://dx.doi.org/10.4314/ahs.v18i4.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354874PMC
December 2018
2 Reads

Levels of heavy metals in urine samples of school children from selected industrial and non-industrial areas in Dar es Salaam, Tanzania.

Afr Health Sci 2018 Dec;18(4):1226-1235

Chemistry Department, University of Dar es Salaam, P. O. Box 35061 Dar es Salaam, Tanzania.

Objectives: The levels of lead, zinc, iron, copper and cadmium metals in the urine samples of selected school children in industrial and non-industrial areas in Dar es Salaam were investigated.

Methods: Urine samples were collected from 120 children in industrial areas and 120 children in non-industrial areas then digested in concentrated acids and analysed using atomic absorption spectrophotometry (AAS).

Results: The concentrations of the heavy metals in the urine samples ranged from below detection limit/non-detectable (ND) to 1. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354869PMC
December 2018

Predictor variables for post-discharge mortality modelling in infants: a protocol development project.

Afr Health Sci 2018 Dec;18(4):1214-1225

Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, Canada.

Background: Over two-thirds of the five million annual deaths in children under five occur in infants, mostly in developing countries and many after hospital discharge. However, there is a lack of understanding of which children are at higher risk based on early clinical predictors. Early identification of vulnerable infants at high-risk for death post-discharge is important in order to craft interventional programs. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354852PMC
December 2018
1 Read

Low birth weight and associated factors among singleton neonates born at Felege Hiwot referral hospital, North West Ethiopia.

Afr Health Sci 2018 Dec;18(4):1204-1213

Department of Epidemiology and Biostatistics, Institute of Public Heath, College of Medicine and Health Science, University of Gondar, Ethiopia.

Background: Low birth weight is one of the public health problems in the globe and it is an indicator of the health of the newborn survival and the mother's nutrition and health status. This study was aimed to determine the prevalence of low birth weight and its associated factors among mothers who gave birth at Bahir Dar Felege Hiwot referral hospital.

Methods: A cross-sectional facility based study was conducted from March 18 to May 18 / 2015. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354871PMC
December 2018
1 Read

Tunisian antibiotic resistance problems: three contexts but one health.

Authors:
Wejdene Mansour

Afr Health Sci 2018 Dec;18(4):1202-1203

Research Unit: Emergent bacterial resistance and Safety of care « UR12SP37 », Department of Microbiology, University Hospital, Sousse -Tunisia.

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http://dx.doi.org/10.4314/ahs.v18i4.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354850PMC
December 2018

Evaluation of antibiotic prescriptions and use in under-five children in Ibadan, SouthWestern Nigeria.

Afr Health Sci 2018 Dec;18(4):1189-1201

Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Background: Irrational antibiotic prescriptions for children is a global concern requiring periodic evaluation and monitoring.

Objectives: To assess appropriateness of antibiotic prescribing for under-five children, as well as evaluating mothers' usage of antibiotics for their under-five and reason(s) for use.

Method: Cross-sectional review of out-patient case-notes of under-five using principles of antibiotic prescribing and a questionnaire-guided interaction with under-five mothers. Read More

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https://www.ajol.info/index.php/ahs/article/view/180319
Publisher Site
http://dx.doi.org/10.4314/ahs.v18i4.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354862PMC
December 2018
6 Reads

Resistance status to deltamethrin pyrethroid of (Diptera: Culicidae) collected from three districts of Tunisia.

Afr Health Sci 2018 Dec;18(4):1182-1188

Laboratory of Genetics, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia.

Objectives: The aim of the present study was to determine the susceptibility status of populations against deltamehtrin insecticide.

Methods: Larvae of were collected from three breeding places in Northern and Southern Tunisia between 2003 and 2005. Early third and late fourth instars were tested against deltamethrin pyrethroid insecticide. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354891PMC
December 2018
2 Reads

Resistance development and insecticide susceptibility in , an important vector of human diseases, against selection pressure of temephos and its relationship to cross-resistance towards organophosphates and pyrethroids insecticides.

Afr Health Sci 2018 Dec;18(4):1175-1181

Laboratory of Genetics, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia.

Background: is an important vector of human diseases.

Objective: To determine the insecticide resistance development in against selection pressure of temephos.. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354882PMC
December 2018

Relationship between Sap prevalence and biofilm formation among resistant clinical isolates of .

Afr Health Sci 2018 Dec;18(4):1166-1174

Department of Microbiology and Biotechnology-Faculty of Pharmacy- Delta University for Science and Technology- International coastal road, Gamasa city, Mansoura, Dakhaliya Egypt.

Background: Fungal infections represent a serious health problem especially in immunocompromised individuals. is the most common fungi that cause superficial and systemic infections with high mortality rates. Anti-fungal resistance of may be attributed to its virulence. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354888PMC
December 2018

Interferon-γ receptor-1 gene promoter polymorphisms and susceptibility for brucellosis in Makkah region.

Afr Health Sci 2018 Dec;18(4):1157-1165

Department of Medical Microbiology, Faculty of Applied Medical Sciences, Taif University, Turabah, 21995, KSA.

Background: Genetic polymorphisms that affect the production levels of certain cytokines and/or their receptors may determine the risk, severity or protection in some infectious diseases like brucellosis.

Objectives: The aim of this study was to investigate the association of certain known Interferon-γ Receptor-1 (IFN-γ R1) gene promoter polymorphisms and the susceptibility to infection with Brucellosis in Saudi population.

Methods: A cases-control association study was conducted in 69 individuals with human brucellosis and 94 healthy individuals. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354847PMC
December 2018

Integrated approach to malaria prevention at household level in rural communities in Wakiso district, Uganda: impact evaluation of a pilot project.

Afr Health Sci 2018 Dec;18(4):1144-1156

School of Sciences, Nkumba University, Entebbe, Uganda.

Background: The integrated approach to malaria prevention, which advocates for the use of several malaria prevention methods at households, is being explored to complement other existing strategies. We implemented a pilot project that promoted the integrated approach to malaria prevention in two rural communities in Wakiso district, Uganda.

Objectives: This paper presents the impact evaluation findings of the project carried out 2 years after implementation with a focus on changes in knowledge and practices on malaria prevention. Read More

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https://www.ajol.info/index.php/ahs/article/view/180303
Publisher Site
http://dx.doi.org/10.4314/ahs.v18i4.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354846PMC
December 2018
7 Reads

Influenza virus A (H1 and H3) and B co-circulation among patient presenting with acute respiratory tract infection in Ibadan, Nigeria.

Afr Health Sci 2018 Dec;18(4):1134-1143

Department of Virology, Faculty of Basic Medical Science, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Influenza is an acute respiratory disease that continues to cause global epidemics and pandemics in human with significant mortality and morbidity.

Objectives: This study was designed to identify the circulating influenza virus in Ibadan, Nigeria during the 2006/2007 season.

Methods: Throat swab samples were collected from patients presenting with acute respiratory tract infection at the Out-Patient Departments of major hospitals in Ibadan over a period of seven months from November 2006 to May 2007. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354865PMC
December 2018

Genetic diversity of hepatitis B co-infection with hepatitis C, D and E viruses among Malaysian chronic hepatitis B patients.

Afr Health Sci 2018 Dec;18(4):1117-1133

Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, University Putra Malaysia.

Background: Hepatitis B virus co-infection with other strains of viral hepatitis is associated with increased risk of liver cirrhosis and hepatic decompensation.

Objectives: This is a prevalence study that assessed the genetic diversity of chronic hepatitis B patients and coinfection.

Methods: Chronic hepatitis B patients enrolled in this study were tested for antibodies of other hepatitis viruses using ELISA kits. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354894PMC
December 2018
1 Read

Tuberculosis prevalence among university freshmen in Zhengzhou, China, during 2004-2013.

Afr Health Sci 2018 Dec;18(4):1109-1116

College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.

Background: Tuberculosis (TB) is a major public health concern worldwide, and spreads more easily in densely populated areas such as school campuses.

Objectives: The aim of this study was to determine the prevalence of positive TB skin tests among freshmen, i.e. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354879PMC
December 2018
1 Read

Feeding difficulties in infants with unrepaired cleft lip and palate and HIV-exposure.

Afr Health Sci 2018 Dec;18(4):1098-1108

Department of Speech-Language Pathology and Audiology, Faculty of Humanities, University of Pretoria Private Bag X20, Hatfield 0028.

Background: There is limited description of the feeding characteristics of infants with unrepaired cleft lip and palate, exposed to HIV, but not necessarily infected.

Objective: To compare the feeding characteristics of infants with unrepaired cleft lip and palate and HIV-exposure, to infants with unrepaired cleft lip and palate only.

Method: A two-group comparative design with a validated measure, the Neonatal Feeding Assessment Scale was used. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354895PMC
December 2018
1 Read

Knowledge, attitude, willingness of HIV counseling and testing and factors associated with it, among long distant drivers in Enugu, Nigeria: an opportunity in reduction of HIV prevalence.

Afr Health Sci 2018 Dec;18(4):1088-1097

College of Medicine, University of Nigeria, Enugu campus, Community Medicine.

Background: Long distance truck drivers (LDTDs) have been one of the key forces in the spread of HIV/AIDS across the African continent.

Objective: We set out to assess the knowledge of HIV transmission route, preventive measures, attitude to HIV Counseling and Testing (HCT), willingness and factors associated with willingness to screen for HIV among long distance truck drivers in Enugu, Nigeria.

Method: This was a cross-sectional study of 500 long distance truck drivers aged 19-65 years. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354848PMC
December 2018

Ethnobotanical study of curative plants used by traditional healers to treat rhinitis in the Limpopo Province, South Africa.

Afr Health Sci 2018 Dec;18(4):1076-1087

Medicinal Plants and Economic Development (MPED) Research Centre, Department of Botany, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.

Background: Studies focusing on plants used medicinally to heal and manage rhinitis are very scarce in Africa and elsewhere.

Objectives: To document plants used by traditional healers (THs) in the treatment and management of rhinitis and related symptoms in the Limpopo Province of South Africa.

Methods: Data was gathered using a semi structured interviews with 105 THs in the Limpopo Province, supplemented by field expeditions for plant specimen collection and observation. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354866PMC
December 2018
1 Read

E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals.

Afr Health Sci 2018 Dec;18(4):1066-1075

Division of Chemical Pathology, National Health Laboratory Service (NHLS) and Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.

Background: E-selectin has been shown to play a role in atherosclerosis and to be increased in HIV-infected individuals due to chronic immune activation. There is a paucity of studies on E-selectin in HIV-infected treatment-naïve individuals.

Objectives: This study aimed to determine whether E-selectin levels were increased in HIV-infected treatment-naïve individuals and whether these correlated with markers of disease severity, inflammation and coagulation to determine if this population is at risk for cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.4314/ahs.v18i4.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354867PMC
December 2018
1 Read

Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria.

Afr Health Sci 2018 Dec;18(4):1057-1065

Virology Unit, Department of Microbiology, University of Ilorin, P.M.B 1515 Ilorin-Nigeria.

Background: Cytomegalovirus (CMV) infection is common among HIV-infected individuals. Its contribution to morbidity and mortality became more apparent following introduction of highly active anti-retroviral therapy (HAART) which improved survival among HIV-infected individuals.

Objectives: This study aimed at determining the prevalence of both active and latent CMV infections among HIV-infected individuals on HAART in Ilorin, Nigeria. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354892PMC
December 2018
1 Read

A comparative assessment of caries risk using cariogram among smokers and smokeless tobacco users in india - a cross-sectional study.

Afr Health Sci 2018 Dec;18(4):1046-1056

Dept. of Public Health Dentistry, Pacific Dental College and Hospital, Debari, Udaipur, Rajasthan, India.

Background: A dearth of literature exists concerning utilization of the unique cariogram model for caries risk assessment in tobacco users.

Objective: To assess & compare caries risk among smokers & smokeless tobacco users using Cariogram model.

Methods: A descriptive cross sectional study was conducted among smokers and smokeless tobacco users of Udaipur for 3 months. Read More

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https://www.ajol.info/index.php/ahs/article/view/180276
Publisher Site
http://dx.doi.org/10.4314/ahs.v18i4.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354858PMC
December 2018
2 Reads

Is Khat chewing habit a risk factor for occlusal caries progression?

Afr Health Sci 2018 Dec;18(4):1036-1045

Department of Community Oral Health & Clinical Prevention, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

Backgrounds: People in Yemen and in East African countries chew khat more than five hours daily.

Objectives: The aim of this study was to assess the relationship between khat and occlusal caries progression.

Methods: A cohort study was carried out among 98 Yemeni khat chewers and 101 non-chewers aged 18-35 years old with early occlusal caries lesions. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354877PMC
December 2018

Investigating the influence of contextual factors in the coordination of chronic mental illness care in a district health system.

Afr Health Sci 2018 Dec;18(4):1027-1035

School of Nursing and Public Health, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Background: The global shift from institution-based to community-based care for chronic mental illness (CMI) care resulted in the de-institutionalization of clients with CMI. However, health systems which have been originally designed for acute hospital-based care do not seem to be appropriately transformed to manage CMI care at a community level.

Aim: The aim of this study was to investigate how contextual factors influenced care coordination for chronic mental illness care within the eThekwini District. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354863PMC
December 2018

Decomposing disparity in adult individual's mental health in Tehran among lower and higher economic groups; an Oaxaca- Blinder analysis on urban HEART Survey- round 2.

Afr Health Sci 2018 Dec;18(4):1018-1026

Substance Use and Dependence Research Center, University of Social Welfare& Rehabilitation Sciences, Tehran, Iran.

Background: Mental health is one of the main aspects of social well-being. Tehran -capital of Iran- is metropolitan, where the mental health status of citizens is not prioritized effectively.

Objectives: The purpose of this study was identifying contributors of mental health inequality between lower and higher economic groups in Tehran through Oaxaca- Blinder method. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354884PMC
December 2018
0.662 Impact Factor

PASCAL laser platform produces less pain responses compared to conventional laser system during the panretinal photocoagulation: a randomized clinical trial.

Afr Health Sci 2018 Dec;18(4):1010-1017

Private Office, Ophthalmology, Afyonkarahisar, Turkey.

Background: Most of patients experience pain during the panretinal photocoagulation(PRP). Laser photocoagulation delivery has advanced with the introduction of pattern-scanning laser systems (PASCAL). Shorter pulse duration and less choroidal penetration believed to reduce pain during the laser treatment. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354857PMC
December 2018

comparative study of carbohydrate antigen 19-9 in sickle cell disease subjects and controls in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

Afr Health Sci 2018 Dec;18(4):1003-1009

Medical laboratory Science department, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State Nigeria.

Background: Sickle cell disease is characterized by chronic complications that affect almost all body organs. Pancreatic disease is rare in SCD. CA 19-9 is a non-specific surrogate marker for pancreatic disease especially carcinoma. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354859PMC
December 2018

Single tube allele specific PCR: a low cost technique for molecular screening of sickle cell anaemia in Nigeria.

Afr Health Sci 2018 Dec;18(4):995-1002

University of Lagos, Department of Cell Biology and Genetics.

Background: Sickle cell anaemia (SCA) is a hereditary blood disorder caused by a single mutation in the haemoglobin gene. The disease burden of SCA is highest in Nigeria. The allele specific polymerase chain reaction (ASPCR) method is applicable for the direct detection of known single nucleotide polymorphisms (SNPs). Read More

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http://dx.doi.org/10.4314/ahs.v18i4.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354853PMC
December 2018

The predictive role of haematological parameters in the diagnosis of osteoarticular brucellosis.

Afr Health Sci 2018 Dec;18(4):988-994

Fırat University Medical Faculty Hospital, Department of Infectious Disease, Elazig, 23000, Turkey.

Background: Brucellosis is a zoonosis that affects several systems, especially with the osteoarticular involvement.

Objectives: This study aims to compare the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), mean platelet volume (MPV) and red blood cell distribution (RDW) in patients with the osteoarticular involvement and those with non-localised brucellosis and evaluate their predictive value for the diagnosis of osteoarticular brucellosis.

Methods: We enrolled 140 patients with brucellosis, 70 with the osteoarticular involvement and 70 without any localised involvement. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354860PMC
December 2018
1 Read

Red blood cell alloimmunization in multi-transfused patients with chronic kidney disease in Port Harcourt, South-South Nigeria.

Afr Health Sci 2018 Dec;18(4):979-987

Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria.

Background: Serological safety is an integral part of overall safety for blood banks.

Objectives: The aim of the study was to determine the prevalence and specificities of red blood cell alloimmunization in multi-transfused patients with chronic kidney disease (CKD).

Methods: A cross-sectional case-control study carried out at the University of Port Harcourt Teaching Hospital in which 186 patients with CKD were enrolled consecutively, 124 had received multiple transfusions (more than one unit of blood in one month, or at least 10 units within 3 months), while 62 had never been transfused. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354886PMC
December 2018
2 Reads

CA 125 is a better marker to differentiate endometrial cancer and abnormal uterine bleeding.

Afr Health Sci 2018 Dec;18(4):972-978

Department of Obstetrics and Gynecology, Jawaharlal Institute of Post graduate Medical Education and Research, Puducherry - 605006.

Background: Incidence of endometrial cancer in India is increasing due to lifestyle changes and obesity. As 5 year survival rate of cancer confined to uterus is good, there is need for serum tumor marker for early diagnosis. This study was designed to identify a tumor marker which differentiate endometrial carcinoma and abnormal uterine bleeding (AUB) because common presentation of endometrial carcinoma is AUB. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354887PMC
December 2018
1 Read

Knowledge and perceptions on childhood asthma among care-takers of children with asthma at a National Referral Hospital in Western Kenya: a descriptive study.

Afr Health Sci 2018 Dec;18(4):965-971

Moi Teaching and Referral Hospital.

Background: Identifying knowledge gaps in asthma self-management and identifying existing myths is an important step in determining appropriate health education and demystifying the myths so as to enhance asthma control.

Objective: To identify existing knowledge gaps and perceptions among the caregivers of asthmatic children.

Methods: A cross sectional study was done among caretakers of asthmatic children aged 6-11 years at Moi Teaching and Referral Hospital. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354861PMC
December 2018
2 Reads

Breast cancer resistance protein (BCRP) gene expression in a cohort of adult Egyptian patients with acute myeloid leukemia.

Afr Health Sci 2018 Dec;18(4):958-964

Department of Clinical and Chemical Pathology, National Cancer Institute, Cairo University, Egypt.

Background: Acute myeloid leukemia (AML), an aggressive clonal disease, is genetically heterozygous. The prognostic role of expression of Breast Cancer Resistance Protein (BCRP) gene, which behaves as a multidrug transporter, in adult AML is ambiguous.

Objective: The objective is to assess the level of mRNA expression of BCRP gene in newly diagnosed cytogenetically normal adult Egyptian AML patients; and to clarify its potential influence and association between therapeutic responsiveness and disease free survival. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354849PMC
December 2018
1 Read

Prevalence of autonomic dysfunction among pre-dialysis chronic kidney disease patients in a tertiary hospital, South East Nigeria.

Afr Health Sci 2018 Dec;18(4):950-957

University of Nigeria teaching hospital, College of Medicine, Ituku/Ozalla, Enugu, Nigeria, Medicine.

Background: Autonomic dysfunction (AD) has been recognized as an important contributor to the poor outcome in chronic kidney disease (CKD) patients. Several studies have reported abnormalities in heart rate variability (HRV) among these patients.

Objectives: To determine the prevalence of Autonomic Dysfunction (AD) in pre-dialysis Chronic Kidney Disease (CKD) patients in a tertiary hospital in South East Nigeria. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354868PMC
December 2018
1 Read

Prevalence and pattern of cardiovascular-related causes of out-of- hospital deaths in Lagos, Nigeria.

Afr Health Sci 2018 Dec;18(4):942-949

College of Medicine, University of Lagos, Medicine.

Background: In developed countries 50% - 75% of deaths from cardiovascular-diseases occurs out-of-hospital. In Nigeria where patronage of orthodox health facilities is low, the impact of cardiovascular-related diseases on out-of-hospital mortality has been sparsely studied.

Objectives: To determine the prevalence and pattern of cardiovascular-related causes of out-of-hospital deaths in Lagos, Nigeria. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354864PMC
December 2018
5 Reads

Prevalence and knowledge of hypertension among people living in rural communities in Ghana: a mixed method study.

Afr Health Sci 2018 Dec;18(4):931-941

School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: Knowledge and understanding of hypertension and its associated health risks remain inadequate despite increasing trend of hypertension prevalence. This study was conducted to assess the prevalence, knowledge and perceptions of hypertension in rural communities in Ghana.

Methods: A mixed method study involving 534 subjects was employed. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354880PMC
December 2018
0.662 Impact Factor

GATA4 molecular screening and assessment of environmental risk factors in a Moroccan cohort with tetralogy of Fallot.

Afr Health Sci 2018 Dec;18(4):922-930

Medico-Surgical Unit of Cardio-Pediatrics, Department of Pediatrics, HASSAN II University Hospital, Fez, Morocco.

Background: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect (CHD) with an incidence of 1/3600 live births. This disorder was associated with mutations in the transcription factors involved in cardiogenesis, like Nk2 homeobox5 (NKX2-5), GATA binding protein4 (GATA4) and T-BOX1 (TBX1). GATA4 contributes particularly to heart looping and differentiation of the second heart field. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354854PMC
December 2018
1 Read

Walking as a feasible means of effecting positive changes in BMI, waist, and blood pressure in black South African women.

Afr Health Sci 2018 Dec;18(4):917-921

Centre for Exercise Science and Sports Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: In the context of a growing obesity pandemic in sub-Saharan African countries little is known on how to address the problem /disease in the region.

Methods: A randomised controlled trial of walking to decrease obesity was conducted using 115 women employed at the University of Venda, Limpopo province. 49 of these participants were randomly selected into an intervention group, which walked for 30 minutes, 3 days per week for a period of 12 weeks on treadmills located in the university gym. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354885PMC
December 2018

Diagnostic performance of several biomarkers for identification of cases of non-communicable diseases among Central Africans.

Afr Health Sci 2018 Dec;18(4):909-916

Faculty of Health Sciences, University of Fort Hare, East London, South Africa.

Background: This study determined the diagnostic performance of new biomarkers for a composite diagnosis of non-communicable diseases (NCDs) among Central Africans.

Methods: This case-control study was conducted at LOMO Medical Centre, Kinshasa, DR Congo (DRC) between January - December, 2008. The cases comprised 226 participants with concurrent presence of at least 2 or more of NCDs. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354856PMC
December 2018
15 Reads
0.662 Impact Factor

Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria.

Afr Health Sci 2018 Dec;18(4):900-908

Department of Biochemistry, School of Sciences, The Federal University of Technology, P.M.B. 704, Akure, Nigeria.

Background: Type 2 Diabetes Mellitus (T2DM) is associated with diabetic nephropathy and hyperlipidemia. Gender, age, medication adherence, lifestyle, culture and socioeconomic status could be sources of diversity in T2DM leading to differences in predisposition, development and clinical presentation.

Objectives: Therefore, this study aimed to investigate the influence of gender, age and treatment duration on kidney and lipid-related biochemical indices of T2DM patients attending Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria (EKSUTH). Read More

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http://dx.doi.org/10.4314/ahs.v18i4.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354870PMC
December 2018
3 Reads

Association of FokI, TaqI, BsmI and ApaI polymorphisms with diabetic retinopathy: a pooled analysis of case-control studies.

Afr Health Sci 2018 Dec;18(4):891-899

Department of Ophthalmology, The First Affiliated Hospital of China Medical University, 110001 Shenyang, China.

Background: To assess synthetically the association between polymorphisms in the vitamin D receptor (VDR) gene (FokI, BsmI, ApaI, and TaqI) and diabetic retinopathy (DR).

Methods: Pubmed, Embase, ISI Web of Science, Google-scholar and CBMDisc, CNKI and Chongqing VIP databases were searched. A meta-analysis was performed. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354855PMC
December 2018
0.662 Impact Factor

Screening for diabetes among tuberculosis patients: a nationwide population-based study in Egypt.

Afr Health Sci 2018 Dec;18(4):884-890

National Research Center, Cairo, Egypt, Department of Community Medicine, Cairo, Egypt.

Background: The prevalence of type 2 diabetes mellitus (DM) is increasing rapidly in Egypt and considered one of the major health problems in the Eastern Mediterranean region.

Objectives: To measure the prevalence of diabetes and detect the undiagnosed cases of diabetes mellitus among patient with tuberculosis.

Methods: Study Design: Nationwide population-based study. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354872PMC
December 2018
1 Read

Impact of weight reduction on insulin resistance, adhesive molecules and adipokines dysregulation among obese type 2 diabetic patients.

Afr Health Sci 2018 Dec;18(4):873-883

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Type 2 diabetes mellitus is usually related to vascular problems and is associated with impairment in endothelial function characterized by impaired endothelial-dependent vasodilation and increased platelet adhesion. There is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of endothelial dysfunction and adipokines dysregulation for obesity associated with type 2 diabetes mellitus.

Objective: This study was designed to detect the effects of weight loss on insulin resistance, adhesive molecules and adipokines dysregulation in obese type 2 diabetic patients. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354881PMC
December 2018
1 Read

HMGA1 variant IVS5-13insC is associated with insulin resistance and type 2 diabetes: an updated meta-analysis.

Afr Health Sci 2018 Dec;18(4):865-872

Sports Science Research Center of Shandong Province, Jinan, 250102, China.

Background: High-mobility group A1 (HMGA1) polymorphism has been suspected as a gene variant associated with type 2 diabetes (T2D). However, conflicting outcomes have been reported.

Objective: This meta-analysis aimed to predict the association between the HMGA1 variant IVS5-13insC and T2D. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354845PMC
December 2018

Audit of insulin prescription patterns and associated burden among diabetics in a tertiary health institution in Nigeria.

Afr Health Sci 2018 Dec;18(4):852-864

Department of Medicine, BOWEN University & BOWEN University Teaching Hospital, Ogbomoso.

Background: Insulin is one of the most important anti-diabetic agents in the management of diabetes even among type 2 diabetic.

Objective: There was need to assess insulin adherence, mode of insulin delivery and burden of insulin usage among diabetics.

Methods: A cross-sectional, prospective questionnaire, orally administered at a Diabetes Clinic of a University Teaching Hospital, SouthWest, Nigeria. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354893PMC
December 2018