Search Our Scientific Publications & Authors

Cell Prolif 2020 Jul 1:e12830. Epub 2020 Jul 1.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Objectives: Skin serves as the major interface between the external environment and body which is liable to many kinds of injuries. Mesenchymal stem cell (MSC) therapy has been widely used and became a promising strategy. Pre-treatment with chemical agents, hypoxia or gene modifications can partially protect MSCs against injury, and the pre-treated MSCs show the improved differentiation, homing capacity, survival and paracrine effects regard to attenuating injury. Read More

Sci Rep 2020 Jun 30;10(1):10625. Epub 2020 Jun 30.

Neural Engineering and Rehabilitation Laboratory, Division of Physical Therapy, School of Medicine, West Virginia University, Morgantown, WV, USA.

The sensorimotor integration during unconstrained reaching movements in the presence of variable environmental forces remains poorly understood. The objective of this study was to quantify how much the primary afferent activity of muscle spindles can contribute to shaping muscle coactivation patterns during reaching movements with complex dynamics. To achieve this objective, we designed a virtual reality task that guided healthy human participants through a set of planar reaching movements with controlled kinematic and dynamic conditions that were accompanied by variable muscle co-contraction. Read More

mBio 2020 Jun 30;11(3). Epub 2020 Jun 30.

Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

Resistance or tolerance to traditional antibiotics is a challenging issue in antimicrobial chemotherapy. Moreover, traditional bactericidal antibiotics kill only actively growing bacterial cells, whereas nongrowing metabolically inactive cells are tolerant to and therefore "persist" in the presence of legacy antibiotics. Here, we report that the diarylurea derivative PQ401, previously characterized as an inhibitor of the insulin-like growth factor I receptor, kills both antibiotic-resistant and nongrowing antibiotic-tolerant methicillin-resistant (MRSA) by lipid bilayer disruption. Read More

Mil Med 2020 Jun 30. Epub 2020 Jun 30.

Division of General Pediatrics, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.

Introduction: Deployment-limiting medical conditions are the primary reason why service members are not medically ready. Service-specific standards guide clinicians in what conditions are restrictive for duty, fitness, and/or deployment requirements. The Air Force (AF) codifies most standards in the Medical Standards Directory (MSD). Read More

JCO Clin Cancer Inform 2020 Jun;4:583-601

Keck School of Medicine, University of Southern California, Los Angeles, CA.

Purpose: Performance status (PS) is a key factor in oncologic decision making, but conventional scales used to measure PS vary among observers. Consumer-grade biometric sensors have previously been identified as objective alternatives to the assessment of PS. Here, we investigate how one such biometric sensor can be used during a clinic visit to identify patients who are at risk for complications, particularly unexpected hospitalizations that may delay treatment or result in low physical activity. Read More

Braz J Otorhinolaryngol 2020 Jun 16. Epub 2020 Jun 16.

Department of Neurology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, P.R. China. Electronic address:

Introduction: Multi-canal benign paroxysmal positional vertigo is considered to be a rare and controversial type in the new diagnostic guidelines of Bárány because the nystagmus is more complicated or atypical, which is worthy of further study.

Objective: Based on the diagnostic criteria for multi-canal benign paroxysmal positional vertigo proposed by International Bárány Society, the study aimed to investigate the clinical characteristics, diagnosis and treatment of multi-canal benign paroxysmal positional vertigo.

Methods: A total of 41 patients with multi-canal benign paroxysmal positional vertigo were included and diagnosed by Roll, Dix-Hallpike and straight head hanging tests. Read More

Chin J Physiol 2020 May-Jun;63(3):128-136

Department of Anesthesiology, Taipei Veterans General Hospital; Graduate Institute of Life Sciences, National Defense Medical Center; Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.

Glucose ingestion attenuates the water ingestion-induced increase in the total peripheral vascular resistance and orthostatic tolerance. We investigated the gastrointestinal physiology of glucose by examining the effect of glucose ingestion on the functional expression of focal adhesion kinase (FAK) in red blood cell (RBC) membrane. This study was performed in 24 young, healthy subjects. Read More

FASEB J 2020 Jun 27. Epub 2020 Jun 27.

Department of Cardiology, The First Medical Center of Chinese PLA General Hospital & Medical School of Chinese PLA, Beijing, China.

Exposure to microgravity results in vascular remodeling and cardiovascular dysfunction. To elucidate the mechanism involved in this condition, we investigated whether endoplasmic reticulum (ER) stress during simulated microgravity induced endothelial inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs). Microgravity was simulated by clinorotation in the current study. Read More

Trends Endocrinol Metab 2020 Jun 23. Epub 2020 Jun 23.

Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY, USA; Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health School of Medicine, New York, NY, USA; Department of Mechanical and Aerospace Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA. Electronic address:

Literature has reported that up to 50% of dental implants may be affected by peri-implantitis, a bacteria-induced chronic inflammatory process, which promotes osteoclast-mediated bone resorption and inhibits bone formation, leading to progressive bone loss around implants. Current evidence points toward an increased risk for the development of peri-implantitis in both obesity/metabolic syndrome (MetS) and diabetes mellitus (DM) conditions relative to the healthy population. Currently, there is no effective treatment for peri-implantitis and the 50% prevalence in MetS and DM, along with its predicted increase in the worldwide population, presents a major concern in implant dentistry as hyperglycemic conditions are associated with bone-healing impairment; this may be through dysfunction of osteocalcin-induced glucose metabolism. Read More

Aerosp Med Hum Perform 2020 Jul;91(7):615

Aerosp Med Hum Perform 2020 Jul;91(7):611-614

Aerosp Med Hum Perform 2020 Jul;91(7):608-610

A readership survey was posted in our monthly newsletter, "Ever Upward", and sent via email to members of the Aerospace Medical Association and to authors and reviewers of the journal, Aerospace Medicine and Human Performance. The reason for the survey concerned whether to publish 6 times (or perhaps 7) per year instead of 12. There were 403 respondents. Read More

Cell Metab 2020 Jun 22. Epub 2020 Jun 22.

Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany. Electronic address:

The combination of aging populations with the obesity pandemic results in an alarming rise in non-communicable diseases. Here, we show that the enigmatic adenosine A2B receptor (A2B) is abundantly expressed in skeletal muscle (SKM) as well as brown adipose tissue (BAT) and might be targeted to counteract age-related muscle atrophy (sarcopenia) as well as obesity. Mice with SKM-specific deletion of A2B exhibited sarcopenia, diminished muscle strength, and reduced energy expenditure (EE), whereas pharmacological A2B activation counteracted these processes. Read More

Comput Methods Programs Biomed 2020 Jun 12;196:105606. Epub 2020 Jun 12.

Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran; Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.

Background And Objective: Microwave-induced thermoacoustic imaging (MITAI) represents an innovative imaging approach for detection of breast cancer at initial phases by integrating the benefits provided by procedures of microwave and ultrasound imaging. The present investigation examines an innovative three-dimensional numerical modeling of MITAI as a problem with multi-physics nature.

Methods: Simulations are performed by the use of COMSOL software. Read More

Front Bioeng Biotechnol 2020 3;8:409. Epub 2020 Jun 3.

Department of Mechanical, Aerospace and Civil Engineering (MACE), The University of Manchester, Manchester, United Kingdom.

Congenital heart disease (CHD) is the most common birth defect globally and coarctation of the aorta (CoA) is one of the commoner CHD conditions, affecting around 1/1800 live births. CoA is considered a CHD of critical severity. Unfortunately, the prognosis for a child born in a low and lower-middle income country (LLMICs) with CoA is far worse than in a high-income country. Read More

J Anat 2020 Jun 24. Epub 2020 Jun 24.

Department of Life Sciences, Research Centre for Musculoskeletal Science & Sports Medicine, Manchester Metropolitan University, Manchester, UK.

Femoral neck anteversion (FNA) is the angle between the femoral neck and femoral shaft, indicating the degree of torsion of the femur. Differences in FNA affect the biomechanics of the hip, through alterations in factors such as moment arm lengths and joint loading. Altered gait associated with differences in FNA may also contribute to the development of a wide range of skeletal disorders including osteoarthritis. Read More

Nanoscale 2020 Jun 24. Epub 2020 Jun 24.

Department of Chemistry, St. John's University, Queens, NY 11439, USA.

The specific detection in clinical samples of analytes with dimensions in the tens to hundreds of nanometers, such as viruses and large proteins, would improve disease diagnosis. Detection of these "mesoscale" analytes (as opposed to their nanoscale components), however, is challenging as it requires the simultaneous binding of multiple recognition sites often spaced over tens of nanometers. In response, we have adapted DNA origami, with its unparalleled customizability to precisely display multiple target-binding sites over the relevant length scale, to an electrochemical biosensor platform. Read More

Int J Comput Assist Radiol Surg 2020 Jun 24. Epub 2020 Jun 24.

School of Aerospace Engineering, Tsinghua University, Beijing, China.

Purpose: Most existing robot systems for pedicle screw placement rely on optical markers to establish the spatial relationship between the surgical tool and the surgical path. Marker installation and registration are time-consuming, and error may also accumulate along the complicated coordinate transformation chain. Therefore, we proposed a markerless structured light-based method to simplify the surgery workflow and the coordinate transformation chain. Read More

J Biomech Eng 2020 Jun 25. Epub 2020 Jun 25.

Nancy and Peter Meinig School of Biomedical Engineering, Cornell University, 4Sibley School of Mechanical and Aerospace Engineering, Cornell University, Weill Hall 149, 526 Campus Road, Ithaca, NY 14853.

Inferior synovial lubrication is a hallmark of osteoarthritis (OA), and synovial fluid (SF) lubrication and composition are variable among OA patients. Hyaluronic acid (HA) viscosupplementation is a widely used therapy for improving SF viscoelasticity and lubrication, but it is unclear how the effectiveness of HA viscosupplements varies with arthritic endotype. The objective of this study was to investigate the effects of the HA viscosupplement, Hymovis®, on the lubricating properties of diseased SF from patients with non-inflammatory OA and inflammatory arthritis (IA). Read More

Int J Antimicrob Agents 2020 Jun 20:106061. Epub 2020 Jun 20.

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Victoria, Australia. Electronic address:

The combination of polymyxin and chloramphenicol possesses synergistic killing against New Delhi metallo-β-lactamase (NDM)-producing Klebsiella pneumoniae. This systems study examined the transcriptomic responses to the polymyxin-chloramphenicol combination in clinical NDM-producing K. pneumoniae isolate S01. Read More

Nano Lett 2020 Jun 25. Epub 2020 Jun 25.

School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore.

Optical tweezers are versatile tools capable of sorting microparticles, yet formidable challenges are present in the separation of nanoparticles smaller than 200 nm. The difficulties arise from the controversy on the requirement of a tightly focused light spot in order to create strong optical forces while a large area is kept for the sorting. To overcome this problem, we create a near-field potential well array with connected tiny hotspots in a large scale. Read More

Undersea Hyperb Med 2020 Second Quarter;47(2):203-210

Department of Underwater and Hyperbaric Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Simulated flight in a hypobaric chamber is a fundamental component in the physiological training of aviators. Although rare, there is always a risk of decompression sickness (DCS) in trainees during hypobaric hypoxia training. In this study we aimed to determine the incidence of altitude-induced DCS and the symptoms manifested in trainees and inside chamber observers (ICOs) during the training sessions. Read More

PLoS One 2020 23;15(6):e0234706. Epub 2020 Jun 23.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Purpose: We assessed whether mitomycin-C (MMC) has different antifibrotic mechanisms in trabeculectomy wound healing.

Methods: We identified 2 concentrations of MMC as "low-dose" by using WST-1 assay, Lactic dehydrogenase assay, and fluorescence-activated cell sorting flow cytometry. Senescence-associated β-galactosidase (SA-β-gal) and fibrotic gene expression was examined through immunocytochemistry, flow cytometry, real-time quantitative reverse transcription polymerase chain reaction, Western blotting, zymography, and modified scratch assay in vitro. Read More

BMC Cancer 2020 Jun 22;20(1):581. Epub 2020 Jun 22.

State key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi Province, 710032, PR China.

Background: Esophageal carcinoma (EC) is the seventh-most prevalent tumor in the world, which is still one of the primary causes of tumor-related death. Identifying noteworthy biomarkers for EC is particularly significant in guiding effective treatment. Recently, circulating tumor cells (CTCs) in peripheral blood (PB) were intensively discussed as prognostic markers in patients with EC. Read More

Bioengineering (Basel) 2020 Jun 18;7(2). Epub 2020 Jun 18.

Biomechanics and Biomaterials Design Laboratory (BBDL), School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USA.

The tricuspid valve (TV) is composed of three leaflets that coapt during systole to prevent deoxygenated blood from re-entering the right atrium. The connection between the TV leaflets' microstructure and the tissue-level mechanical responses has yet to be fully understood in the TV biomechanics society. This pilot study sought to examine the load-dependent collagen fiber architecture of the three TV leaflets, by employing a multiscale, combined experimental approach that utilizes tissue-level biaxial mechanical characterizations, micro-level collagen fiber quantification, and histological analysis. Read More

Oxid Med Cell Longev 2020 21;2020:6841581. Epub 2020 May 21.

Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi'an 710038, China.

Persistent senescence seems to exert detrimental effects fostering ageing and age-related disorders, such as cancer. Chemotherapy is one of the most valuable treatments for cancer, but its clinical application is limited due to adverse side effects. Melatonin is a potent antioxidant and antiageing molecule, is nontoxic, and enhances the efficacy and reduces the side effects of chemotherapy. Read More

J Oncol 2020 28;2020:3656841. Epub 2020 May 28.

Department of Psychiatry, The Second People's Hospital of Hunan Province, The Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.

Background: Patients diagnosed with schizophrenia were found having lower risks to develop cancers, including glioma. Based on this epidemiology, we hypothesized that there were gene profiles playing opposite roles in pathogenesis of schizophrenia and glioma.

Methods: Based on GEO datasets and TCGA, key genes of schizophrenia genes on the opposite development of glioma were screened by different expressed genes (DEGs) screening, weighted gene coexpression network analysis (WGCNA), disease-specific survival (DSS), and glioma grading and verified by gene set enrichment analysis (GSEA). Read More

Neural Plast 2020 27;2020:5743972. Epub 2020 May 27.

Research Institute for Aerospace Medicine, Inha University, Incheon, Republic of Korea.

Vestibular nucleus (VN) and cerebellar flocculus are known as the core candidates for the neuroplasticity of vestibular system. However, it has been still elusive how to induce the artificial neuroplasticity, especially caused by an electrical stimulation, and assess the neuronal information related with the plasticity. To understand the electrically induced neuroplasticity, the neuronal potentials in VN responding to the repeated electrical stimuli were examined. Read More

J Emerg Med 2020 Jun 18. Epub 2020 Jun 18.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: In 2010, the American Heart Association recommended that postcardiac arrest care should be included in the chain of survival to reduce permanent neurological damage, improve quality of life, and reduce health care expenses of postcardiac arrest care.

Objectives: To investigate post-in-hospital cardiac arrest (IHCA) survival prior to and after modification of the chain of survival in 2010, with subgroup analyses per age and concomitant coronary heart disease (CHD).

Methods: We retrospectively searched the National Health Insurance Research Database for the 2007-2015 period to collect case data coded as "427. Read More

Gait Posture 2020 Jun 12;80:280-284. Epub 2020 Jun 12.

Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Via Franco Faggiana 1668, 04100, Latina, Italy; Movement Analysis Laboratory, Policlinico Italia, Piazza del Campidano, 6, 00162, Rome, Italy.

Background: Subjects with transfemoral amputation (TFA) show an asymmetric gait pattern associated with a decreased ability to recover mechanical energy and an increased metabolic cost of walking.

Research Question: This study aimed to identify the spatio-temporal and kinematic gait variables correlated with mechanical energy values in subjects with TFA and to observe the ability of the identified parameters to discriminate between TFA and controls according to the type of prosthesis.

Methods: The gait of 40 subjects with TFA was evaluated with a motion 3-D optoelectronic system. Read More

Neurosci Bull 2020 Jun 20. Epub 2020 Jun 20.

Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.

Int Arch Occup Environ Health 2020 Jun 19. Epub 2020 Jun 19.

Occupational Medicine, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.

Objectives: Due to the professionally specific risk of infection in the armed forces, recommendations for vaccination are usually adapted for soldiers and are subject to special regulations. Little data is available on scientifically measured vaccination coverage of soldiers.

Methods: A systematic literature research was carried out in the PubMed database using the search terms "army" or "military" or "Bundeswehr" and "vaccination" or "vaccine". Read More

Int J Infect Dis 2020 Jun 16. Epub 2020 Jun 16.

Department of Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:

Background: Sepsis causes varying degrees of thrombocytopenia that are closely related to the likelihood of patient mortality. We analysed the effect of recombinant human thrombopoietin (rhTPO) on the platelet count in critically ill patients with sepsis-associated thrombocytopenia and provided a reference for its treatment.

Material/methods: The study was a retrospective analysis of the clinical data of patients. Read More

Mayo Clin Proc 2020 Jun 16. Epub 2020 Jun 16.

Division of Preventive, Occupational, and Aerospace Medicine, Mayo Clinic, Rochester, MN.

Contact tracing is a cornerstone of communicable disease containment and involves identifying, quarantining, and monitoring contacts of infected people. Although contact tracing is a known evidence-based strategy in the community setting, the COVID-19 pandemic highlighted the challenges to implementing labor-intensive contact tracing in the occupational setting of large health care systems and hospitals, the epicenter of the pandemic. We present a framework for feasible, scalable COVID-19 contact tracing in a large multistate health system in the United States employing approximately 69,000 health care personnel. Read More

Surg Oncol 2020 Jun 6;33:108-117. Epub 2020 Feb 6.

Department of Thoracic Surgery, Xi'an Chest Hospital, The Eastern Section of Aerospace Avenue, Chang'an District, Xi'an, Shaanxi, 710100, China. Electronic address:

Background: Tyrosine-protein kinase Fyn (FYN) plays a crucial role in Src family, which participates in the signal transduction of brain nerves and the development and activation of T lymphocytes in physiological conditions. We probed into the roles and mechanisms of FYN in lung adenocarcinoma (LUAD).

Methods: Cell activity, apoptosis, invasion, and migration were detected by CCK-8, FCM, transwell, and wound-healing assays, respectively. Read More

Cardiovasc Eng Technol 2020 Jun 16. Epub 2020 Jun 16.

Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.

Purpose: The left atrium and left ventricle are the primary inflow cannulation sites for heart failure patients supported by rotary blood pumps (RBPs). Haemodynamic differences exist between inflow cannulation sites and have been well characterized at rest, yet the effect during exercise with the same centrifugal RBP has not been previously well established. The purpose of this study was to investigate the hemodynamic effect of inflow cannulation site during rest and exercise with the same centrifugal RBP. Read More

Crit Care 2020 06 18;24(1):357. Epub 2020 Jun 18.

Department of Anesthesiology, School of Medicine, University of California, San Diego, CA, USA.

Med J Islam Repub Iran 2020 16;34:21. Epub 2020 Mar 16.

Infectious Diseases Research Center, Aerospace and Subaquatic Medicine Faculty, Aja University of Medical Sciences, Tehran, Iran.

The fatal pandemics of infectious diseases and the possibility of using microorganisms as biological weapons are both rising worldwide. Hospitals are vital organizations in response to biological disasters and have a crucial role in the treatment of patients. Despite the advances in studies about hospital planning and performance during crises, there are no internationally accepted standards for hospital preparedness and disaster response. Read More

ACS Omega 2020 Jun 14;5(21):12451-12466. Epub 2020 May 14.

Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.

Oxidative stress occurs when physiological antioxidant systems do not manage to counteract the excessive intracellular production of reactive oxygen species (ROS), which accumulate leading to irreversible oxidation of DNA and other biomacromolecules, and thus to the onset of pathological conditions. Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disease characterized by autosomal recessive mutations in the sacsin gene (). It has been demonstrated that cells of ARSACS patients show bioenergetic and mitochondrial impairment, denoted by reduced respiratory chain activities and ATP synthesis. Read More

Sci Rep 2020 Jun 16;10(1):9730. Epub 2020 Jun 16.

Centre de Recherche Hôpital Maisonneuve-Rosemont, Montréal, Canada.

We introduced and validated a drop-on-demand method to print cells. The method uses low energy nanosecond laser (wavelength: 532 nm) pulses to generate a transient microbubble at the distal end of a glass microcapillary supplied with bio-ink. Microbubble expansion results in the ejection of a cell-containing micro-jet perpendicular to the irradiation axis, a method we coined Laser Induced Side Transfer (LIST). Read More

Medicine (Baltimore) 2020 Jun;99(24):e20645

Department of Anesthesiology, Aerospace Center Hospital, Beijing, China.

Background: Appropriate pain management is essential to improve the postoperative recovery after total knee arthroplasty (TKA). There is a paucity of literature on ketamine for TKA procedures. The aim of this study was to evaluate the analgesic efficacy of ketamine in patients undergoing primary TKA. Read More

Am J Phys Med Rehabil 2020 Jun 10. Epub 2020 Jun 10.

Department of Rehabilitation Medicine, NYU Langone Health.

Air Med J 2020 May - Jun;39(3):221. Epub 2020 Apr 3.

Air Med J 2020 May - Jun;39(3):149-153. Epub 2020 Apr 6.

Elife 2020 Jun 15;9. Epub 2020 Jun 15.

Department of Molecular Biology, Princeton University, Princeton, United States.

Determining how microtubules (MTs) are nucleated is essential for understanding how the cytoskeleton assembles. While the MT nucleator, γ-tubulin ring complex (γ-TuRC) has been identified, precisely how γ-TuRC nucleates a MT remains poorly understood. Here we developed a single molecule assay to directly visualize nucleation of a MT from purified γ-TuRC. Read More

Nanomedicine 2020 Jun 10:102235. Epub 2020 Jun 10.

Department of Mechanical and Aerospace Engineering; Department of Bioengineering; Materials Science and Engineering, University of California San Diego. Electronic address:

Aβ deposition is a pathological hallmark of Alzheimer's disease (AD). Besides the full-length amyloid forming peptides (Aβ and Aβ), biochemical analyses of brain deposits have identified a variety of N- and C-terminally truncated Aβ variants in sporadic and familial AD patients. However, their relevance for AD pathogenesis remains largely understudied. Read More

J Chromatogr B Analyt Technol Biomed Life Sci 2020 May 3;1151:122141. Epub 2020 May 3.

Tongji University School of Medicine, Shanghai 200092, China; Department of Clinical Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China. Electronic address:

A novel and potent anti-tuberculosis drug combination pyrazinamide (PZA), ethambutol (EMB), protionamide (PTO), and clofazimine (CFZ) that rapidly kills Mycobacterium tuberculosis (Mtb) in the lungs has been identified using the artificial-intelligence-enabled parabolic response surface approach. A universal and highly sensitive two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC-MS/MS) method for the simultaneous determination of PZA, EMB, PTO, and CFZ in various biological samples in different states (liquid samples: plasma, bile, and urine; solid samples: tissue and feces) using simple pretreatment was established and validated. For the first dimension of this column-switching arrangement, the automated purification and enrichment of the drugs were achieved on a Polar-RP column. Read More

PLoS One 2020 11;15(6):e0234361. Epub 2020 Jun 11.

Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany.

Artificial gravity elicited through short-arm human centrifugation combined with physical exercise, such as jumping, is promising in maintaining health and performance during space travel. However, motion sickness symptoms could limit the tolerability of the approach. Therefore, we determined the feasibility and tolerability, particularly occurrence of motion sickness symptoms, during reactive jumping exercises on a short-arm centrifuge. Read More

Arch Osteoporos 2020 Jun 10;15(1):87. Epub 2020 Jun 10.

Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.

We investigated longitudinal changes in tibia bone strength in master power (jumping and sprinting) and endurance (distance) athletes of both sexes. Bone mass but not cross-sectional moment of inertia was better maintained in power than endurance athletes over time, particularly in men and independent of changes in performance.

Objective: Assessment of effects of sex and athletic discipline (lower limb power events, e. Read More

Eur J Case Rep Intern Med 2020 9;7(6):001495. Epub 2020 Apr 9.

Faculty of Medicine, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.

Tuberculosis is one of the major health problems in developing countries affecting different organs such as bone and joints. One of the most important involvements of osteoarticular tuberculosis is that of the sacroiliac joint. In addition, its incidence has increased over the past several years. Read More