Search Our Scientific Publications & Authors

J Neurointerv Surg 2022 Jun 24. Epub 2022 Jun 24.

Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, New York, USA.

Background: Determining stroke etiology is crucial for secondary prevention, but intensive workups fail to classify ~30% of strokes that are cryptogenic.

Objective: To examine the hypothesis that the transcriptomic profiles of clots retrieved during mechanical thrombectomy are unique to strokes of different subtypes.

Methods: We isolated RNA from the clots of 73 patients undergoing mechanical thrombectomy. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Jun 24. Epub 2022 Jun 24.

B&VIIT Eye Center, B2 GT Tower, 1317-23 Seocho-Dong, Seocho-Gu, Seoul, South Korea.

Purpose: Myopic regression after surgery is the most common long-term complication of refractive surgery, but it is difficult to identify myopic regression without long-term observation. This study aimed to develop machine learning models to identify high-risk patients for refractive regression based on preoperative data and fundus photography.

Methods: This retrospective study assigned subjects to the training (n = 1606 eyes) and validation (n = 403 eyes) datasets with chronological data splitting. Read More

Vaccines (Basel) 2022 Jun 1;10(6). Epub 2022 Jun 1.

The Department of Defense Global Emerging Infections Surveillance Branch, Armed Forces Health Surveillance Division, Wright-Patterson Air Force Base, Dayton, OH 45433, USA.

The objective of this study was to assess inactivated influenza vaccine effectiveness (VE) by time since vaccination in adults aged ≥ 18 years using a test-negative design. All data were obtained from the US Department of Defense Global Respiratory Pathogen Surveillance Program over four influenza seasons, from 2016-2017 through 2019-2020. Analyses were performed to estimate VE using a generalized linear mixed model with logit link and binomial distribution. Read More

Micromachines (Basel) 2022 Jun 8;13(6). Epub 2022 Jun 8.

Department of Mechanical and Aerospace Engineering, Old Dominion University, Norfolk, VA 23529, USA.

Microfluidics has seen a remarkable growth over the past few decades, with its extensive applications in engineering, medicine, biology, chemistry, etc [... Read More

J Clin Med 2022 Jun 14;11(12). Epub 2022 Jun 14.

Department of Neurosurgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.

Early brain injury is considered to be a primary reason for the poor prognosis of patients suffering from subarachnoid hemorrhage (SAH). Due to its pro-inflammatory activity, cold-inducible RNA-binding protein (CIRP) has been implicated in the ischemic brain insult, but its possible interplay with hypothermia in SAH treatment remains to be evaluated. One-hundred and thirty-eight Sprague-Dawley rats (300-350 g males) were randomly allocated into the following groups: sham-operated (Sham); SAH; and SAH + hypothermia (SAH + H), each comprised of 46 animals. Read More

Int J Mol Sci 2022 Jun 9;23(12). Epub 2022 Jun 9.

Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Commercial space industries are emergent, bolstered by new exciting rocket systems, orbital and landing vehicles, the creation of multi-country orbital platforms, satellite technology, the renewed promise of low Earth orbit (LEO) business opportunities, as well as promised planetary exploration [... Read More

Cells 2022 Jun 20;11(12). Epub 2022 Jun 20.

Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, FL 32610, USA.

The promising outcomes of chimeric antigen receptor (CAR) T cell therapy in hematologic malignancies potentiates its capability in the fight against many cancers. Nevertheless, this immunotherapy modality needs significant improvements for the treatment of solid tumors. Researchers have incrementally identified limitations and constantly pursued better CAR designs. Read More

Comput Methods Programs Biomed 2022 Jun 13;222:106938. Epub 2022 Jun 13.

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA. Electronic address:

Background And Objective: Arteriovenous fistulae (AVF) are the preferred mode of hemodialysis vascular access and their successful maturation is critical to reduce patient morbidity, mortality, cost, and improve quality of life. Peri-anastomotic venous segment stenosis is the primary cause of AVF maturation failure. The objective is to develop a software protocol for the functional analysis of arteriovenous fistula. Read More

Gels 2022 Jun 14;8(6). Epub 2022 Jun 14.

Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.

Three-dimensional (3D) printing has great potential for creating tissues and organs to meet shortfalls in transplant supply, and biomaterial inks are key components of many such approaches. There is a need for biomaterial inks that facilitate integration, infiltration, and vascularization of targeted 3D-printed structures. This study is therefore focused on creating new biomaterial inks from self-assembled capillary alginate gel (Capgel), which possesses a unique microstructure of uniform tubular channels with tunable diameters and densities. Read More

Behav Sci (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy.

Many automotive industries are developing technologies to assist human drivers in suggesting wiser choices to improve drivers' behaviour. The technology that makes use of this modality is defined as a "digital nudge". An example of a digital nudge is the GPS that is installed on smartphones. Read More

Pharmacology 2022 Jun 22:1-9. Epub 2022 Jun 22.

Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Beijing, China.

Introduction: Abundant studies have disclosed that proteins can function as pivotal tumor promoters or suppressors in cancers' progression. This work was planned to investigate the regulatory function of N-myristoyltransferase-1 (NMT1) on non-small cell lung cancer (NSCLC) and the underlying molecular mechanisms.

Methods: The self-renewal abilities were assessed through a spheroid-formation assay. Read More

Sci Adv 2022 Jun 22;8(25):eabp9734. Epub 2022 Jun 22.

Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO, USA.

Laser-assisted fabrication of conductive materials on flexible substrates has attracted intense interests because of its simplicity, easy customization, and broad applications. However, it remains challenging to achieve laser scribing of conductive materials on tissue-like soft elastomers, which can serve as the basis to construct bioelectronics and soft actuators. Here, we report laser scribing of metallic conductive, photoactive transition metal oxide (molybdenum dioxide) on soft elastomers, coated with molybdenum chloride precursors, under ambient conditions. Read More

Aerosp Med Hum Perform 2022 Jun;93(6):499-506

Little has been studied to promote aviation health in South Korea. The aim of this study was to analyze the results of aviation medical examinations conducted in South Korea over the past 5 yr and, in doing so, provide evidence for establishing a health promotion, disease prevention plan. Subjects of the study consisted of applicants who underwent aviation medical examinations from January 1, 2016, to December 31, 2020. Read More

Eur J Neurol 2022 Jun 20. Epub 2022 Jun 20.

German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.

Background: Animal studies have elicited therapeutic potential of severe ambient hypoxia for neurodegenerative diseases. However, uncertainties exist relative to individual (mal-)adaption mechanisms of the brain to hypoxia. To investigate the effects of hypoxia on cognitive performance and cerebral morphology, two healthy professional mountaineers (participants A and B) conducted a 35-day study with 14 consecutive days of exposure to oxygen concentrations between 8% and 8. Read More

Biomed Mater 2022 Jun 20. Epub 2022 Jun 20.

Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid (UC3M), Avenida de la Universidad, 30, Leganés (Madrid), Leganes, Madrid, 28911, SPAIN.

Cell spheroids have recently emerged as an effective tool to recapitulate native microenvironments of living organisms in an in vitro scenario, increasing the reliability of the results obtained and broadening their applications in regenerative medicine, cancer research, disease modeling and drug screening. In this study the generation of spheroids containing primary human dermal fibroblasts (dHFs) was approached using the two-widely employed methods: hanging-drop (HD) and U-shape low adhesion plate (LA-plate). Moreover, extrusion-based 3D bioprinting was introduced to achieve a standardized and scalable production of cell spheroids, decreasing considerably the possibilities of human error. Read More

Neural Netw 2022 Jun 7;153:164-178. Epub 2022 Jun 7.

Yale School of Medicine, Yale University, New Haven, 06510 CT, USA. Electronic address:

Our work intends to show that: (1) Quantum Neural Networks (QNNs) can be mapped onto spin-networks, with the consequence that the level of analysis of their operation can be carried out on the side of Topological Quantum Field Theory (TQFT); (2) A number of Machine Learning (ML) key-concepts can be rephrased by using the terminology of TQFT. Our framework provides as well a working hypothesis for understanding the generalization behavior of DNNs, relating it to the topological features of the graph structures involved. Read More

Curr Issues Mol Biol 2022 Jan 27;44(2):654-669. Epub 2022 Jan 27.

NASA Johnson Space Center, Houston, TX 77058, USA.

The effect of confined and isolated experience on astronauts' health is an important factor to consider for future space exploration missions. The more confined and isolated humans are, the more likely they are to develop negative behavioral or cognitive conditions such as a mood decline, sleep disorder, depression, fatigue and/or physiological problems associated with chronic stress. Molecular mediators of chronic stress, such as cytokines, stress hormones or reactive oxygen species (ROS) are known to induce cellular damage including damage to the DNA. Read More

Pan Afr Med J 2022 22;41:235. Epub 2022 Mar 22.

Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Introduction: visuospatial is a type of high-level visual perception necessary for identification, information integration, analysing of visual and spatial forms, details, structures and spatial relation. These functions are required in order to successfully complete aviation-related tasks, such as analysing movement, distance perception, and spatial navigation. The aim of this study is to examine whether hypobaric hypoxia can significantly influence changes in visuospatial function, thus increasing the risk of accident or serious incident during flight operation. Read More

Front Oncol 2022 2;12:857827. Epub 2022 Jun 2.

State Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Background: Retroperitoneal liposarcomas (RPLs), sarcoma of mesenchymal origin, are the most common soft tissue sarcomas (STS) of the retroperitoneum. Given the rarity of RPLs, the prognostic values of clinicopathological features in the patients remain unclear. The nomogram can provide a visual interface to aid in calculating the predicted probability that a patient will achieve a particular clinical endpoint and communication with patients. Read More

Neuropsychologia 2022 Jun 15:108306. Epub 2022 Jun 15.

Department of Psychology, The Pennsylvania State University, University Park, PA, USA.

When people are placed in a situation where they are at risk of substantiating a negative stereotype about their social group (a scenario termed stereotype threat), the extra pressure to avoid this outcome can undermine their performance. Substantial and consistent gender disparities in STEM fields leave women vulnerable to stereotype threat, including the stereotype that women are not as good at generating creative and innovative ideas as men. We tested whether female students' creative thinking is affected by a stereotype threat by measuring power in the alpha frequency band (8-12Hz oscillations) that has been associated with better creative thinking outcomes. Read More

J Oncol 2022 6;2022:6345160. Epub 2022 Jun 6.

School of Aerospace Medicine, Air Force Medical University, Xi'an, China.

Objective: Alterations in the methylation state of pseudogenes may serve as clinically useful biomarkers of glioblastomas (GBMs) that do not have glioma-CpG island methylator phenotype (G-CIMP).

Methods: Non-G-CIMP GBM datasets were included for evaluation, and a RISK-score signature was determined from the methylation state of pseudogene loci. Both bioinformatic and experimental analyses were performed for biological validation. Read More

Biomed Res Int 2022 7;2022:5501171. Epub 2022 Jun 7.

Chinese PLA Medical School, Beijing 100853, China.

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer deaths in the world and often diagnosed at an advanced stage, so it is urgent to explore the pathogenesis and new diagnostic biomarkers. Accumulated evidences suggested that small nucleolar RNAs (snoRNAs) played a key role in the development and progression of NSCLC. To examine differential expression snoRNA profile and identify snoRNAs with clinical significance in lung adenocarcinoma (LUAD), The Cancer Genome Atlas (TCGA) LUAD RNA sequencing dataset was used to investigate differential expression snoRNA signatures and compared with snoRNA PCR array analysis in pair-matched LUAD tissues. Read More

Sci Rep 2022 Jun 15;12(1):9976. Epub 2022 Jun 15.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, 2010, Australia.

Mechanosensitive (MS) ion channels are primary transducers of mechanical force into electrical and/or chemical intracellular signals. Many diverse MS channel families have been shown to respond to membrane forces. As a result of this intimate relationship with the membrane and proximal lipids, amphipathic compounds exert significant effects on the gating of MS channels. Read More

Ophthalmic Physiol Opt 2022 Jun 16. Epub 2022 Jun 16.

Department of Mechanical, Materials and Aerospace Engineering, School of Engineering, University of Liverpool, Liverpool, UK.

Purpose: To investigate whether Pentacam densitometry readings are affected by corneal tilt.

Methods: In a prospective study, the right eyes of 86 healthy participants aged 42.8 ± 20. Read More

Glob Health Epidemiol Genom 2022 31;2022:6499217. Epub 2022 May 31.

US Air Force School of Aerospace Medicine, Wright Patterson AFB, OH 45433, USA.

The 2019 coronavirus disease (COVID-19) pandemic has demonstrated the importance of predicting, identifying, and tracking mutations throughout a pandemic event. As the COVID-19 global pandemic surpassed one year, several variants had emerged resulting in increased severity and transmissibility. Here, we used PCR as a surrogate for viral load and consequent severity to evaluate the real-world capabilities of a genome-based clinical severity predictive algorithm. Read More

Circ Res 2022 Jun 14:101161CIRCRESAHA121320565. Epub 2022 Jun 14.

Department of Surgery (D.C., E.P., R.P.Y., M.N.C., I.-T.C., J.C., J.Y., L.Z., J.-E.I.Y., J.S.Y., B.N., S.L., Y.J.S., W.J., Y.-K.H.).

Background: Mutations in cause human lymphatic malformations. We have previously uncovered an Orai1-mediated mechanotransduction pathway that triggers lymphatic sprouting through Notch downregulation in response to fluid flow. However, the identity of its upstream mechanosensor remains unknown. Read More

IEEE J Biomed Health Inform 2022 Jun 13;PP. Epub 2022 Jun 13.

Negative mood states include tension, depression, anger, fatigue, and confusion, which represent the weak internal emotions of a human. Negative mood states exert adverse impact on individuals' ability to make rational decisions, which entails the practicable method of negative mood state detection. The most commonly used negative mood state detection methods are based on the psychological scale, which requires additional work and brings inconvenience to the subject in the application scenarios. Read More

ACS Appl Mater Interfaces 2022 Jun 12;14(24):28403. Epub 2022 Jun 12.

Department of Aerospace Engineering, Pennsylvania State University, University Park, Pennsylvania 16801, United States.

J Thorac Dis 2022 May;14(5):1607-1619

Department of Internal Medicine-Cardiovascular Disease, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Background: Accurate myocardial infarction (AMI) is one of the leading causes of mortality worldwide. N6-methyladenosine (m6A) modification plays an important role in the development of cardiac remodeling and the cardiomyocyte contractile function. The aim of this study is to analyze the m6A-related molecular biological mechanisms of AMI in terms of accurate diagnosis and prognosis. Read More

Sci Rep 2022 Jun 11;12(1):9668. Epub 2022 Jun 11.

Department of Materials Physics, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan.

Microscopy by Achromatic X-rays With Emission of Laminar Light (MAXWELL) is a new X-ray/visible technique with attractive characteristics including isotropic resolution in all directions, large-volume imaging and high throughput. An ultrathin, laminar X-ray beam produced by a Wolter type I mirror irradiates the sample stimulating the emission of visible light by scintillating nanoparticles, captured by an optical system. Three-dimensional (3D) images are obtained by scanning the specimen with respect to the laminar beam. Read More