20,848 results match your criteria Aerospace Medicine


Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis.

Cell Prolif 2020 Jul 1:e12830. Epub 2020 Jul 1.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Objectives: Skin serves as the major interface between the external environment and body which is liable to many kinds of injuries. Mesenchymal stem cell (MSC) therapy has been widely used and became a promising strategy. Pre-treatment with chemical agents, hypoxia or gene modifications can partially protect MSCs against injury, and the pre-treated MSCs show the improved differentiation, homing capacity, survival and paracrine effects regard to attenuating injury. Read More

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http://dx.doi.org/10.1111/cpr.12830DOI Listing

Computational evidence for nonlinear feedforward modulation of fusimotor drive to antagonistic co-contracting muscles.

Sci Rep 2020 Jun 30;10(1):10625. Epub 2020 Jun 30.

Neural Engineering and Rehabilitation Laboratory, Division of Physical Therapy, School of Medicine, West Virginia University, Morgantown, WV, USA.

The sensorimotor integration during unconstrained reaching movements in the presence of variable environmental forces remains poorly understood. The objective of this study was to quantify how much the primary afferent activity of muscle spindles can contribute to shaping muscle coactivation patterns during reaching movements with complex dynamics. To achieve this objective, we designed a virtual reality task that guided healthy human participants through a set of planar reaching movements with controlled kinematic and dynamic conditions that were accompanied by variable muscle co-contraction. Read More

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http://dx.doi.org/10.1038/s41598-020-67403-wDOI Listing

The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus.

mBio 2020 Jun 30;11(3). Epub 2020 Jun 30.

Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

Resistance or tolerance to traditional antibiotics is a challenging issue in antimicrobial chemotherapy. Moreover, traditional bactericidal antibiotics kill only actively growing bacterial cells, whereas nongrowing metabolically inactive cells are tolerant to and therefore "persist" in the presence of legacy antibiotics. Here, we report that the diarylurea derivative PQ401, previously characterized as an inhibitor of the insulin-like growth factor I receptor, kills both antibiotic-resistant and nongrowing antibiotic-tolerant methicillin-resistant (MRSA) by lipid bilayer disruption. Read More

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http://dx.doi.org/10.1128/mBio.01140-20DOI Listing

Digitizing U.S. Air Force Medical Standards for the Creation and Validation of a Readiness Decision Support System.

Mil Med 2020 Jun 30. Epub 2020 Jun 30.

Division of General Pediatrics, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.

Introduction: Deployment-limiting medical conditions are the primary reason why service members are not medically ready. Service-specific standards guide clinicians in what conditions are restrictive for duty, fitness, and/or deployment requirements. The Air Force (AF) codifies most standards in the Medical Standards Directory (MSD). Read More

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http://dx.doi.org/10.1093/milmed/usaa129DOI Listing

Quantified Kinematics to Evaluate Patient Chemotherapy Risks in Clinic.

JCO Clin Cancer Inform 2020 Jun;4:583-601

Keck School of Medicine, University of Southern California, Los Angeles, CA.

Purpose: Performance status (PS) is a key factor in oncologic decision making, but conventional scales used to measure PS vary among observers. Consumer-grade biometric sensors have previously been identified as objective alternatives to the assessment of PS. Here, we investigate how one such biometric sensor can be used during a clinic visit to identify patients who are at risk for complications, particularly unexpected hospitalizations that may delay treatment or result in low physical activity. Read More

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http://dx.doi.org/10.1200/CCI.20.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328110PMC

Clinical characteristics of patients with multi-canal benign paroxysmal positional vertigo.

Braz J Otorhinolaryngol 2020 Jun 16. Epub 2020 Jun 16.

Department of Neurology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, P.R. China. Electronic address:

Introduction: Multi-canal benign paroxysmal positional vertigo is considered to be a rare and controversial type in the new diagnostic guidelines of Bárány because the nystagmus is more complicated or atypical, which is worthy of further study.

Objective: Based on the diagnostic criteria for multi-canal benign paroxysmal positional vertigo proposed by International Bárány Society, the study aimed to investigate the clinical characteristics, diagnosis and treatment of multi-canal benign paroxysmal positional vertigo.

Methods: A total of 41 patients with multi-canal benign paroxysmal positional vertigo were included and diagnosed by Roll, Dix-Hallpike and straight head hanging tests. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.05.012DOI Listing

Glucose reduces the osmopressor response in connection with the tyrosine phosphorylation of focal adhesion kinase in red blood cells.

Chin J Physiol 2020 May-Jun;63(3):128-136

Department of Anesthesiology, Taipei Veterans General Hospital; Graduate Institute of Life Sciences, National Defense Medical Center; Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.

Glucose ingestion attenuates the water ingestion-induced increase in the total peripheral vascular resistance and orthostatic tolerance. We investigated the gastrointestinal physiology of glucose by examining the effect of glucose ingestion on the functional expression of focal adhesion kinase (FAK) in red blood cell (RBC) membrane. This study was performed in 24 young, healthy subjects. Read More

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http://dx.doi.org/10.4103/CJP.CJP_32_20DOI Listing

Endoplasmic reticulum stress-dependent activation of iNOS/NO-NF-κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity.

FASEB J 2020 Jun 27. Epub 2020 Jun 27.

Department of Cardiology, The First Medical Center of Chinese PLA General Hospital & Medical School of Chinese PLA, Beijing, China.

Exposure to microgravity results in vascular remodeling and cardiovascular dysfunction. To elucidate the mechanism involved in this condition, we investigated whether endoplasmic reticulum (ER) stress during simulated microgravity induced endothelial inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs). Microgravity was simulated by clinorotation in the current study. Read More

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http://dx.doi.org/10.1096/fj.202000734RDOI Listing

Obesity/Metabolic Syndrome and Diabetes Mellitus on Peri-implantitis.

Trends Endocrinol Metab 2020 Jun 23. Epub 2020 Jun 23.

Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY, USA; Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health School of Medicine, New York, NY, USA; Department of Mechanical and Aerospace Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA. Electronic address:

Literature has reported that up to 50% of dental implants may be affected by peri-implantitis, a bacteria-induced chronic inflammatory process, which promotes osteoclast-mediated bone resorption and inhibits bone formation, leading to progressive bone loss around implants. Current evidence points toward an increased risk for the development of peri-implantitis in both obesity/metabolic syndrome (MetS) and diabetes mellitus (DM) conditions relative to the healthy population. Currently, there is no effective treatment for peri-implantitis and the 50% prevalence in MetS and DM, along with its predicted increase in the worldwide population, presents a major concern in implant dentistry as hyperglycemic conditions are associated with bone-healing impairment; this may be through dysfunction of osteocalcin-induced glucose metabolism. Read More

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http://dx.doi.org/10.1016/j.tem.2020.05.005DOI Listing

This Month in Aerospace Medicine History.

Authors:

Aerosp Med Hum Perform 2020 Jul;91(7):615

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http://dx.doi.org/10.3357/AMHP.5644.2020DOI Listing

Comments on the Readership Survey Concerning Bi-Monthly Publication.

Authors:
Pamela C Day

Aerosp Med Hum Perform 2020 Jul;91(7):608-610

A readership survey was posted in our monthly newsletter, "Ever Upward", and sent via email to members of the Aerospace Medical Association and to authors and reviewers of the journal, Aerospace Medicine and Human Performance. The reason for the survey concerned whether to publish 6 times (or perhaps 7) per year instead of 12. There were 403 respondents. Read More

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http://dx.doi.org/10.3357/AMHP.5662.2020DOI Listing

Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.

Cell Metab 2020 Jun 22. Epub 2020 Jun 22.

Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany. Electronic address:

The combination of aging populations with the obesity pandemic results in an alarming rise in non-communicable diseases. Here, we show that the enigmatic adenosine A2B receptor (A2B) is abundantly expressed in skeletal muscle (SKM) as well as brown adipose tissue (BAT) and might be targeted to counteract age-related muscle atrophy (sarcopenia) as well as obesity. Mice with SKM-specific deletion of A2B exhibited sarcopenia, diminished muscle strength, and reduced energy expenditure (EE), whereas pharmacological A2B activation counteracted these processes. Read More

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http://dx.doi.org/10.1016/j.cmet.2020.06.006DOI Listing

Numerical study of microwave induced thermoacoustic imaging for initial detection of cancer of breast on anatomically realistic breast phantom.

Comput Methods Programs Biomed 2020 Jun 12;196:105606. Epub 2020 Jun 12.

Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran; Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.

Background And Objective: Microwave-induced thermoacoustic imaging (MITAI) represents an innovative imaging approach for detection of breast cancer at initial phases by integrating the benefits provided by procedures of microwave and ultrasound imaging. The present investigation examines an innovative three-dimensional numerical modeling of MITAI as a problem with multi-physics nature.

Methods: Simulations are performed by the use of COMSOL software. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105606DOI Listing

A Patient-Specific CFD Pipeline Using Doppler Echocardiography for Application in Coarctation of the Aorta in a Limited Resource Clinical Context.

Front Bioeng Biotechnol 2020 3;8:409. Epub 2020 Jun 3.

Department of Mechanical, Aerospace and Civil Engineering (MACE), The University of Manchester, Manchester, United Kingdom.

Congenital heart disease (CHD) is the most common birth defect globally and coarctation of the aorta (CoA) is one of the commoner CHD conditions, affecting around 1/1800 live births. CoA is considered a CHD of critical severity. Unfortunately, the prognosis for a child born in a low and lower-middle income country (LLMICs) with CoA is far worse than in a high-income country. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283385PMC

Femoral anteversion: significance and measurement.

J Anat 2020 Jun 24. Epub 2020 Jun 24.

Department of Life Sciences, Research Centre for Musculoskeletal Science & Sports Medicine, Manchester Metropolitan University, Manchester, UK.

Femoral neck anteversion (FNA) is the angle between the femoral neck and femoral shaft, indicating the degree of torsion of the femur. Differences in FNA affect the biomechanics of the hip, through alterations in factors such as moment arm lengths and joint loading. Altered gait associated with differences in FNA may also contribute to the development of a wide range of skeletal disorders including osteoarthritis. Read More

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http://dx.doi.org/10.1111/joa.13249DOI Listing

An electrochemical biosensor exploiting binding-induced changes in electron transfer of electrode-attached DNA origami to detect hundred nanometer-scale targets.

Nanoscale 2020 Jun 24. Epub 2020 Jun 24.

Department of Chemistry, St. John's University, Queens, NY 11439, USA.

The specific detection in clinical samples of analytes with dimensions in the tens to hundreds of nanometers, such as viruses and large proteins, would improve disease diagnosis. Detection of these "mesoscale" analytes (as opposed to their nanoscale components), however, is challenging as it requires the simultaneous binding of multiple recognition sites often spaced over tens of nanometers. In response, we have adapted DNA origami, with its unparalleled customizability to precisely display multiple target-binding sites over the relevant length scale, to an electrochemical biosensor platform. Read More

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http://dx.doi.org/10.1039/d0nr00952kDOI Listing

Markerless robotic pedicle screw placement based on structured light tracking.

Int J Comput Assist Radiol Surg 2020 Jun 24. Epub 2020 Jun 24.

School of Aerospace Engineering, Tsinghua University, Beijing, China.

Purpose: Most existing robot systems for pedicle screw placement rely on optical markers to establish the spatial relationship between the surgical tool and the surgical path. Marker installation and registration are time-consuming, and error may also accumulate along the complicated coordinate transformation chain. Therefore, we proposed a markerless structured light-based method to simplify the surgery workflow and the coordinate transformation chain. Read More

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http://dx.doi.org/10.1007/s11548-020-02215-xDOI Listing

Inflammatory and Non-Inflammatory Synovial Fluids Exhibit New & Distinct Tribological Endotypes.

J Biomech Eng 2020 Jun 25. Epub 2020 Jun 25.

Nancy and Peter Meinig School of Biomedical Engineering, Cornell University, 4Sibley School of Mechanical and Aerospace Engineering, Cornell University, Weill Hall 149, 526 Campus Road, Ithaca, NY 14853.

Inferior synovial lubrication is a hallmark of osteoarthritis (OA), and synovial fluid (SF) lubrication and composition are variable among OA patients. Hyaluronic acid (HA) viscosupplementation is a widely used therapy for improving SF viscoelasticity and lubrication, but it is unclear how the effectiveness of HA viscosupplements varies with arthritic endotype. The objective of this study was to investigate the effects of the HA viscosupplement, Hymovis®, on the lubricating properties of diseased SF from patients with non-inflammatory OA and inflammatory arthritis (IA). Read More

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http://dx.doi.org/10.1115/1.4047628DOI Listing

Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol.

Int J Antimicrob Agents 2020 Jun 20:106061. Epub 2020 Jun 20.

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Victoria, Australia. Electronic address:

The combination of polymyxin and chloramphenicol possesses synergistic killing against New Delhi metallo-β-lactamase (NDM)-producing Klebsiella pneumoniae. This systems study examined the transcriptomic responses to the polymyxin-chloramphenicol combination in clinical NDM-producing K. pneumoniae isolate S01. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106061DOI Listing

Optical Potential-Well Array for High-Selectivity, Massive Trapping and Sorting at Nanoscale.

Nano Lett 2020 Jun 25. Epub 2020 Jun 25.

School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore.

Optical tweezers are versatile tools capable of sorting microparticles, yet formidable challenges are present in the separation of nanoparticles smaller than 200 nm. The difficulties arise from the controversy on the requirement of a tightly focused light spot in order to create strong optical forces while a large area is kept for the sorting. To overcome this problem, we create a near-field potential well array with connected tiny hotspots in a large scale. Read More

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http://dx.doi.org/10.1021/acs.nanolett.0c01464DOI Listing

Incidence of decompression sickness in hypobaric hypoxia training.

Undersea Hyperb Med 2020 Second Quarter;47(2):203-210

Department of Underwater and Hyperbaric Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Simulated flight in a hypobaric chamber is a fundamental component in the physiological training of aviators. Although rare, there is always a risk of decompression sickness (DCS) in trainees during hypobaric hypoxia training. In this study we aimed to determine the incidence of altitude-induced DCS and the symptoms manifested in trainees and inside chamber observers (ICOs) during the training sessions. Read More

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Antifibrotic role of low-dose mitomycin-c-induced cellular senescence in trabeculectomy models.

PLoS One 2020 23;15(6):e0234706. Epub 2020 Jun 23.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Purpose: We assessed whether mitomycin-C (MMC) has different antifibrotic mechanisms in trabeculectomy wound healing.

Methods: We identified 2 concentrations of MMC as "low-dose" by using WST-1 assay, Lactic dehydrogenase assay, and fluorescence-activated cell sorting flow cytometry. Senescence-associated β-galactosidase (SA-β-gal) and fibrotic gene expression was examined through immunocytochemistry, flow cytometry, real-time quantitative reverse transcription polymerase chain reaction, Western blotting, zymography, and modified scratch assay in vitro. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234706PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310836PMC

Prognostic value of circulating tumor cells detected with the CellSearch system in esophageal cancer patients: a systematic review and meta-analysis.

BMC Cancer 2020 Jun 22;20(1):581. Epub 2020 Jun 22.

State key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi Province, 710032, PR China.

Background: Esophageal carcinoma (EC) is the seventh-most prevalent tumor in the world, which is still one of the primary causes of tumor-related death. Identifying noteworthy biomarkers for EC is particularly significant in guiding effective treatment. Recently, circulating tumor cells (CTCs) in peripheral blood (PB) were intensively discussed as prognostic markers in patients with EC. Read More

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http://dx.doi.org/10.1186/s12885-020-07059-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310134PMC

A Pilot Study on Linking Tissue Mechanics with Load-Dependent Collagen Microstructures in Porcine Tricuspid Valve Leaflets.

Bioengineering (Basel) 2020 Jun 18;7(2). Epub 2020 Jun 18.

Biomechanics and Biomaterials Design Laboratory (BBDL), School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USA.

The tricuspid valve (TV) is composed of three leaflets that coapt during systole to prevent deoxygenated blood from re-entering the right atrium. The connection between the TV leaflets' microstructure and the tissue-level mechanical responses has yet to be fully understood in the TV biomechanics society. This pilot study sought to examine the load-dependent collagen fiber architecture of the three TV leaflets, by employing a multiscale, combined experimental approach that utilizes tissue-level biaxial mechanical characterizations, micro-level collagen fiber quantification, and histological analysis. Read More

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http://dx.doi.org/10.3390/bioengineering7020060DOI Listing

Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing.

Oxid Med Cell Longev 2020 21;2020:6841581. Epub 2020 May 21.

Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi'an 710038, China.

Persistent senescence seems to exert detrimental effects fostering ageing and age-related disorders, such as cancer. Chemotherapy is one of the most valuable treatments for cancer, but its clinical application is limited due to adverse side effects. Melatonin is a potent antioxidant and antiageing molecule, is nontoxic, and enhances the efficacy and reduces the side effects of chemotherapy. Read More

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http://dx.doi.org/10.1155/2020/6841581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260648PMC

Genetic Profiles Playing Opposite Roles of Pathogenesis in Schizophrenia and Glioma.

J Oncol 2020 28;2020:3656841. Epub 2020 May 28.

Department of Psychiatry, The Second People's Hospital of Hunan Province, The Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.

Background: Patients diagnosed with schizophrenia were found having lower risks to develop cancers, including glioma. Based on this epidemiology, we hypothesized that there were gene profiles playing opposite roles in pathogenesis of schizophrenia and glioma.

Methods: Based on GEO datasets and TCGA, key genes of schizophrenia genes on the opposite development of glioma were screened by different expressed genes (DEGs) screening, weighted gene coexpression network analysis (WGCNA), disease-specific survival (DSS), and glioma grading and verified by gene set enrichment analysis (GSEA). Read More

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http://dx.doi.org/10.1155/2020/3656841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275202PMC

Repeated Galvanic Vestibular Stimulation Modified the Neuronal Potential in the Vestibular Nucleus.

Neural Plast 2020 27;2020:5743972. Epub 2020 May 27.

Research Institute for Aerospace Medicine, Inha University, Incheon, Republic of Korea.

Vestibular nucleus (VN) and cerebellar flocculus are known as the core candidates for the neuroplasticity of vestibular system. However, it has been still elusive how to induce the artificial neuroplasticity, especially caused by an electrical stimulation, and assess the neuronal information related with the plasticity. To understand the electrically induced neuroplasticity, the neuronal potentials in VN responding to the repeated electrical stimuli were examined. Read More

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http://dx.doi.org/10.1155/2020/5743972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273393PMC

A Population-Based Retrospective Analysis of Post-In-Hospital Cardiac Arrest Survival after Modification of the Chain of Survival.

J Emerg Med 2020 Jun 18. Epub 2020 Jun 18.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: In 2010, the American Heart Association recommended that postcardiac arrest care should be included in the chain of survival to reduce permanent neurological damage, improve quality of life, and reduce health care expenses of postcardiac arrest care.

Objectives: To investigate post-in-hospital cardiac arrest (IHCA) survival prior to and after modification of the chain of survival in 2010, with subgroup analyses per age and concomitant coronary heart disease (CHD).

Methods: We retrospectively searched the National Health Insurance Research Database for the 2007-2015 period to collect case data coded as "427. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.04.045DOI Listing

Pelvic obliquity as a compensatory mechanism leading to lower energy recovery: Characterization among the types of prostheses in subjects with transfemoral amputation.

Gait Posture 2020 Jun 12;80:280-284. Epub 2020 Jun 12.

Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Via Franco Faggiana 1668, 04100, Latina, Italy; Movement Analysis Laboratory, Policlinico Italia, Piazza del Campidano, 6, 00162, Rome, Italy.

Background: Subjects with transfemoral amputation (TFA) show an asymmetric gait pattern associated with a decreased ability to recover mechanical energy and an increased metabolic cost of walking.

Research Question: This study aimed to identify the spatio-temporal and kinematic gait variables correlated with mechanical energy values in subjects with TFA and to observe the ability of the identified parameters to discriminate between TFA and controls according to the type of prosthesis.

Methods: The gait of 40 subjects with TFA was evaluated with a motion 3-D optoelectronic system. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.06.013DOI Listing

Image-Forming Visual Basis of Empathy for Pain in Mice.

Neurosci Bull 2020 Jun 20. Epub 2020 Jun 20.

Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.

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http://dx.doi.org/10.1007/s12264-020-00528-0DOI Listing

Vaccination coverage rates of military personnel worldwide: a systematic review of the literature.

Int Arch Occup Environ Health 2020 Jun 19. Epub 2020 Jun 19.

Occupational Medicine, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.

Objectives: Due to the professionally specific risk of infection in the armed forces, recommendations for vaccination are usually adapted for soldiers and are subject to special regulations. Little data is available on scientifically measured vaccination coverage of soldiers.

Methods: A systematic literature research was carried out in the PubMed database using the search terms "army" or "military" or "Bundeswehr" and "vaccination" or "vaccine". Read More

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http://dx.doi.org/10.1007/s00420-020-01559-wDOI Listing

Recombinant human thrombopoietin in critically ill patients with sepsis-associated thrombocytopenia: A Clinical Study.

Int J Infect Dis 2020 Jun 16. Epub 2020 Jun 16.

Department of Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:

Background: Sepsis causes varying degrees of thrombocytopenia that are closely related to the likelihood of patient mortality. We analysed the effect of recombinant human thrombopoietin (rhTPO) on the platelet count in critically ill patients with sepsis-associated thrombocytopenia and provided a reference for its treatment.

Material/methods: The study was a retrospective analysis of the clinical data of patients. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.045DOI Listing

A Framework for Sustainable Contact Tracing and Exposure Investigation for Large Health Systems.

Mayo Clin Proc 2020 Jun 16. Epub 2020 Jun 16.

Division of Preventive, Occupational, and Aerospace Medicine, Mayo Clinic, Rochester, MN.

Contact tracing is a cornerstone of communicable disease containment and involves identifying, quarantining, and monitoring contacts of infected people. Although contact tracing is a known evidence-based strategy in the community setting, the COVID-19 pandemic highlighted the challenges to implementing labor-intensive contact tracing in the occupational setting of large health care systems and hospitals, the epicenter of the pandemic. We present a framework for feasible, scalable COVID-19 contact tracing in a large multistate health system in the United States employing approximately 69,000 health care personnel. Read More

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http://dx.doi.org/10.1016/j.mayocp.2020.05.008DOI Listing

Overexpression of FYN suppresses the epithelial-to-mesenchymal transition through down-regulating PI3K/AKT pathway in lung adenocarcinoma.

Surg Oncol 2020 Jun 6;33:108-117. Epub 2020 Feb 6.

Department of Thoracic Surgery, Xi'an Chest Hospital, The Eastern Section of Aerospace Avenue, Chang'an District, Xi'an, Shaanxi, 710100, China. Electronic address:

Background: Tyrosine-protein kinase Fyn (FYN) plays a crucial role in Src family, which participates in the signal transduction of brain nerves and the development and activation of T lymphocytes in physiological conditions. We probed into the roles and mechanisms of FYN in lung adenocarcinoma (LUAD).

Methods: Cell activity, apoptosis, invasion, and migration were detected by CCK-8, FCM, transwell, and wound-healing assays, respectively. Read More

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http://dx.doi.org/10.1016/j.suronc.2020.02.002DOI Listing

Haemodynamic Effect of Left Atrial and Left Ventricular Cannulation with a Rapid Speed Modulated Rotary Blood Pump During Rest and Exercise: Investigation in a Numerical Cardiorespiratory Model.

Cardiovasc Eng Technol 2020 Jun 16. Epub 2020 Jun 16.

Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.

Purpose: The left atrium and left ventricle are the primary inflow cannulation sites for heart failure patients supported by rotary blood pumps (RBPs). Haemodynamic differences exist between inflow cannulation sites and have been well characterized at rest, yet the effect during exercise with the same centrifugal RBP has not been previously well established. The purpose of this study was to investigate the hemodynamic effect of inflow cannulation site during rest and exercise with the same centrifugal RBP. Read More

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http://dx.doi.org/10.1007/s13239-020-00471-1DOI Listing

Single ventilator for multiple patients during COVID19 surge: matching and balancing patients.

Crit Care 2020 06 18;24(1):357. Epub 2020 Jun 18.

Department of Anesthesiology, School of Medicine, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1186/s13054-020-03041-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301050PMC

Factors affecting hospital response in biological disasters: A qualitative study.

Med J Islam Repub Iran 2020 16;34:21. Epub 2020 Mar 16.

Infectious Diseases Research Center, Aerospace and Subaquatic Medicine Faculty, Aja University of Medical Sciences, Tehran, Iran.

The fatal pandemics of infectious diseases and the possibility of using microorganisms as biological weapons are both rising worldwide. Hospitals are vital organizations in response to biological disasters and have a crucial role in the treatment of patients. Despite the advances in studies about hospital planning and performance during crises, there are no internationally accepted standards for hospital preparedness and disaster response. Read More

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http://dx.doi.org/10.34171/mjiri.34.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293813PMC

Development of Nanostructured Lipid Carriers for the Delivery of Idebenone in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.

ACS Omega 2020 Jun 14;5(21):12451-12466. Epub 2020 May 14.

Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.

Oxidative stress occurs when physiological antioxidant systems do not manage to counteract the excessive intracellular production of reactive oxygen species (ROS), which accumulate leading to irreversible oxidation of DNA and other biomacromolecules, and thus to the onset of pathological conditions. Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disease characterized by autosomal recessive mutations in the sacsin gene (). It has been demonstrated that cells of ARSACS patients show bioenergetic and mitochondrial impairment, denoted by reduced respiratory chain activities and ATP synthesis. Read More

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http://dx.doi.org/10.1021/acsomega.0c01282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271403PMC

Drop-on-demand cell bioprinting via Laser Induced Side Transfer (LIST).

Sci Rep 2020 Jun 16;10(1):9730. Epub 2020 Jun 16.

Centre de Recherche Hôpital Maisonneuve-Rosemont, Montréal, Canada.

We introduced and validated a drop-on-demand method to print cells. The method uses low energy nanosecond laser (wavelength: 532 nm) pulses to generate a transient microbubble at the distal end of a glass microcapillary supplied with bio-ink. Microbubble expansion results in the ejection of a cell-containing micro-jet perpendicular to the irradiation axis, a method we coined Laser Induced Side Transfer (LIST). Read More

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http://dx.doi.org/10.1038/s41598-020-66565-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298022PMC

The efficacy of ketamine in total knee arthroplasty: a randomized controlled trial protocol.

Medicine (Baltimore) 2020 Jun;99(24):e20645

Department of Anesthesiology, Aerospace Center Hospital, Beijing, China.

Background: Appropriate pain management is essential to improve the postoperative recovery after total knee arthroplasty (TKA). There is a paucity of literature on ketamine for TKA procedures. The aim of this study was to evaluate the analgesic efficacy of ketamine in patients undergoing primary TKA. Read More

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http://dx.doi.org/10.1097/MD.0000000000020645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302669PMC

What's the Deal with Eye-Hand Coordination Post-Stroke?

Am J Phys Med Rehabil 2020 Jun 10. Epub 2020 Jun 10.

Department of Rehabilitation Medicine, NYU Langone Health.

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http://dx.doi.org/10.1097/PHM.0000000000001497DOI Listing

The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy.

Elife 2020 Jun 15;9. Epub 2020 Jun 15.

Department of Molecular Biology, Princeton University, Princeton, United States.

Determining how microtubules (MTs) are nucleated is essential for understanding how the cytoskeleton assembles. While the MT nucleator, γ-tubulin ring complex (γ-TuRC) has been identified, precisely how γ-TuRC nucleates a MT remains poorly understood. Here we developed a single molecule assay to directly visualize nucleation of a MT from purified γ-TuRC. Read More

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http://dx.doi.org/10.7554/eLife.54253DOI Listing

Ion channel formation by N-terminally truncated Aβ (4-42): relevance for the pathogenesis of Alzheimer's disease.

Nanomedicine 2020 Jun 10:102235. Epub 2020 Jun 10.

Department of Mechanical and Aerospace Engineering; Department of Bioengineering; Materials Science and Engineering, University of California San Diego. Electronic address:

Aβ deposition is a pathological hallmark of Alzheimer's disease (AD). Besides the full-length amyloid forming peptides (Aβ and Aβ), biochemical analyses of brain deposits have identified a variety of N- and C-terminally truncated Aβ variants in sporadic and familial AD patients. However, their relevance for AD pathogenesis remains largely understudied. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102235DOI Listing

Validation of a universal and highly sensitive two-dimensional liquid chromatography-tandem mass spectrometry methodology for the quantification of pyrazinamide, ethambutol, protionamide, and clofazimine in different biological matrices.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 May 3;1151:122141. Epub 2020 May 3.

Tongji University School of Medicine, Shanghai 200092, China; Department of Clinical Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China. Electronic address:

A novel and potent anti-tuberculosis drug combination pyrazinamide (PZA), ethambutol (EMB), protionamide (PTO), and clofazimine (CFZ) that rapidly kills Mycobacterium tuberculosis (Mtb) in the lungs has been identified using the artificial-intelligence-enabled parabolic response surface approach. A universal and highly sensitive two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC-MS/MS) method for the simultaneous determination of PZA, EMB, PTO, and CFZ in various biological samples in different states (liquid samples: plasma, bile, and urine; solid samples: tissue and feces) using simple pretreatment was established and validated. For the first dimension of this column-switching arrangement, the automated purification and enrichment of the drugs were achieved on a Polar-RP column. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122141DOI Listing

Motion sickness symptoms during jumping exercise on a short-arm centrifuge.

PLoS One 2020 11;15(6):e0234361. Epub 2020 Jun 11.

Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany.

Artificial gravity elicited through short-arm human centrifugation combined with physical exercise, such as jumping, is promising in maintaining health and performance during space travel. However, motion sickness symptoms could limit the tolerability of the approach. Therefore, we determined the feasibility and tolerability, particularly occurrence of motion sickness symptoms, during reactive jumping exercises on a short-arm centrifuge. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234361PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289365PMC

Greater maintenance of bone mineral content in male than female athletes and in sprinting and jumping than endurance athletes: a longitudinal study of bone strength in elite masters athletes.

Arch Osteoporos 2020 Jun 10;15(1):87. Epub 2020 Jun 10.

Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.

We investigated longitudinal changes in tibia bone strength in master power (jumping and sprinting) and endurance (distance) athletes of both sexes. Bone mass but not cross-sectional moment of inertia was better maintained in power than endurance athletes over time, particularly in men and independent of changes in performance.

Objective: Assessment of effects of sex and athletic discipline (lower limb power events, e. Read More

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http://dx.doi.org/10.1007/s11657-020-00757-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286845PMC

Tuberculous Sacroiliitis after a Penicillin Injection: A Case Report.

Eur J Case Rep Intern Med 2020 9;7(6):001495. Epub 2020 Apr 9.

Faculty of Medicine, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.

Tuberculosis is one of the major health problems in developing countries affecting different organs such as bone and joints. One of the most important involvements of osteoarticular tuberculosis is that of the sacroiliac joint. In addition, its incidence has increased over the past several years. Read More

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http://dx.doi.org/10.12890/2020_001495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279915PMC