770 results match your criteria Advances in wound care[Journal]


Current in vitro biofilm-infected chronic wound models for developing new treatment possibilities.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

University of Copenhagen, International Health, Immunology and Microbiology, Blegdamsvej 3b, opgang 24.1, Copenhagen, Denmark, DK-2200.

Significance: The prevalence of chronic wounds is increasing worldwide. The most recent estimates suggest that up to 2% of the population in the industrialized countries are affected.1 Recent Advances: During the past few decades, bacterial biofilms have been elucidated as one of the primary reasons why chronic wounds fail to heal. Read More

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http://dx.doi.org/10.1089/wound.2020.1176DOI Listing

Assessment of transdermal delivery of topical compounds in skin scarring using a novel combined approach of Raman spectroscopy and HPLC.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

University of Manchester, Plastic & Reconstructive Surgery Research, Manchester Institute of Biotechnology, Manchester, United Kingdom of Great Britain and Northern Ireland.

Objective: The goal of any topical formulation is efficient transdermal delivery of its active components. However, delivery of compounds can be problematic with penetration through tough layers of fibrotic dermal scar tissue.

Approach: We propose a new combined approach using high performance liquid chromatography (HPLC) and Raman spectroscopy (RS) in assessment of penetration of topicals used in scar management. Read More

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http://dx.doi.org/10.1089/wound.2020.1154DOI Listing

Evidence-Based Review of Anti-Biofilm Agents for Wound Care.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

University of Miami Miller School of Medicine, 12235, Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, Miami, Florida, United States;

Significance Biofilms in vivo are small densely packed aggregations of microbes that are highly resistant to host immune responses and treatment. Biofilms attach to each other and to nearby surfaces. They are difficult to study and identify in a clinical setting as their quantification necessitates the use of advanced microscopy techniques such as confocal scanning laser microscopy (CLSM). Read More

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http://dx.doi.org/10.1089/wound.2020.1193DOI Listing

A large mammalian model of myocardial regeneration after myocardial infarction in fetal sheep.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

University of Colorado-Denver, Department of Surgery, Aurora, Colorado, United States;

Objective: Ischemic heart disease accounts for over 20% of all deaths worldwide. As the global population faces a rising burden of chronic diseases, such as hypertension, hyperlipidemia, and diabetes, the prevalence of heart failure due to ischemic heart disease is estimated to increase. We sought to develop a model that may more accurately identify therapeutic targets to mitigate the development of heart failure following MI. Read More

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http://dx.doi.org/10.1089/wound.2018.0894DOI Listing

Approaches to modulate the chronic wound environment using localized nucleic acid delivery.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

Massachusetts Institute of Technology, 2167, Chemical Engineering, Cambridge, Massachusetts, United States.

Significance: Non-healing wounds have been the subject of decades of basic and clinical research. Despite new knowledge about the biology of impaired wound healing, little progress has been made in treating chronic wounds, leaving patients with few therapeutic options. Diabetic ulcers are a particularly common form of non-healing wound. Read More

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http://dx.doi.org/10.1089/wound.2020.1167DOI Listing

Diagnostics for Wound Infections.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

University of Texas at Arlington, 12329, Box 19138, Arlington, Texas, United States, 76019;

Significance: Infections can significantly delay the healing process in chronic wounds placing an enormous economic burden on health care resources. Identification of infection biomarkers and imaging modalities to observe and quantify them has seen progress over the years. Recent Advances: Traditionally, clinicians determine the presence of infection through visual observation of wounds and confirm their diagnosis through wound culture. Read More

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http://dx.doi.org/10.1089/wound.2019.1103DOI Listing

Self-Assembled Nanomaterials for Chronic Skin Wound Healing.

Adv Wound Care (New Rochelle) 2020 Jun 2. Epub 2020 Jun 2.

Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA.

Chronic wounds are one of the major burdens of the U.S. health care system with an annual cost of $31. Read More

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http://dx.doi.org/10.1089/wound.2019.1077DOI Listing

Adipose-Derived Mesenchymal Stromal Cells in Regenerative Medicine: State of Play, Current Clinical Trials, and Future Prospects.

Adv Wound Care (New Rochelle) 2020 Jun 2. Epub 2020 Jun 2.

Faculties of Medicine and Pharmacy, University of Limoges, Myelin Maintenance and Peripheral Neuropathies (EA 6309), Limoges, France.

Wound healing is a complex process involving pain and inflammation, where innervation plays a central role. Managing wound healing and pain remains an important issue, especially in pathologies such as excessive scarring (often leading to fibrosis) or deficient healing, leading to chronic wounds. Advances in therapies using mesenchymal stromal cells offer new insights for treating indications that previously lacked options. Read More

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http://dx.doi.org/10.1089/wound.2020.1175DOI Listing

Are Antimicrobial Peptide Dendrimers an Escape from ESKAPE?

Adv Wound Care (New Rochelle) 2020 May 19. Epub 2020 May 19.

Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.

The crisis of antimicrobial resistance (AMR) increases dramatically despite all efforts to use available antibiotics or last resort antimicrobial agents. The spread of the AMR, declared as one of the most important health-related issues, warrants the development of new antimicrobial strategies. Antimicrobial peptides (AMPs) and AMP dendrimers (AMPDs), as well as polymer dendrimers are relatively new and promising strategies with the potential to overcome drug resistance issues arising in ESKAPE pathogens (, , , and species) colonizing chronic wounds. Read More

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http://dx.doi.org/10.1089/wound.2019.1113DOI Listing

Deleterious Musculoskeletal Conditions Secondary to Lower Limb Loss: Considerations for Prosthesis-Related Factors.

Adv Wound Care (New Rochelle) 2020 May 22. Epub 2020 May 22.

DoD-VA Extremity Trauma & Amputation Center of Excellence, Bethesda, Maryland, USA.

The intent of this work was to summarize the existing evidence of, and highlight knowledge gaps specific to, prosthetic devices/componentry and training regimes, particularly in the context of the human-device interaction and deleterious musculoskeletal conditions secondary to lower limb loss. With the recent and evolving technological advancements in prostheses, there are numerous devices available to individuals with lower limb loss. Current literature demonstrates the importance of expanding the knowledge of all prosthetic device-specific factors and the significance of proper prescription, fit, and alignment, along with adequate device-/activity-specific training, to enhance human-device interaction, reduce gait abnormalities and compensatory motions, and as a result, mitigate risk for secondary musculoskeletal conditions. Read More

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http://dx.doi.org/10.1089/wound.2019.1079DOI Listing

Negative Pressure Wound Therapy in Pediatric Burn Patients: A Systematic Review.

Adv Wound Care (New Rochelle) 2020 Apr 22. Epub 2020 Apr 22.

Hôpitaux Universitaires de Genève, 27230, Department of surgery , Geneva, GE, Switzerland;

Significance Negative Pressure Wound Therapy (NPWT) requires the placement of a dressing over a wound, covered with an adhesive film, and applying to these dressing a negative pressure in a controlled fashion. This therapy is a powerful complement to surgical care of wounds. Data is however poor on its use in pediatrics burns. Read More

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http://dx.doi.org/10.1089/wound.2019.1089DOI Listing

Microneedles in Smart Drug Delivery.

Adv Wound Care (New Rochelle) 2020 May 28. Epub 2020 May 28.

Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico.

In biomedical setup, at large, and drug delivery, in particular, transdermal patches, hypodermal needles, and/or dermatological creams with the topical appliance are among the most widely practiced routes for transdermal drug delivery. Owing to the stratum corneum layer of the skin, traditional drug delivery methods are inefficient, and the effect of the administered therapeutic cues is limited. The current advancement at the microlevel and nanolevel has revolutionized the drug delivery sector. Read More

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http://dx.doi.org/10.1089/wound.2019.1122DOI Listing

Nanotechnology Approaches in Chronic Wound Healing.

Adv Wound Care (New Rochelle) 2020 Jun 2. Epub 2020 Jun 2.

Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain.

The incidence of chronic wounds is increasing due to our aging population and the augment of people afflicted with diabetes. With the extended knowledge on the biological mechanisms underlying these diseases, there is a novel influx of medical technologies into the conventional wound care market. Several nanotechnologies have been developed demonstrating unique characteristics that address specific problems related to wound repair mechanisms. Read More

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http://dx.doi.org/10.1089/wound.2019.1094DOI Listing

The Northwestern Abdominoplasty Scar Model: A Tool for High-Throughput Assessment of Scar Therapeutics.

Adv Wound Care (New Rochelle) 2020 Apr 29. Epub 2020 Apr 29.

Department of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Scar management is an important concern in plastic surgery. Scar models that best mimic human scarring are essential for understanding scar development and progression, assessing the efficacy of therapeutics, and providing reliable and valid research outcomes. In 2016, Lanier proposed a new patient model, the Northwestern Abdominoplasty Scar Model, that overcomes the prior limitations of both animal and human models, with greater representativeness of the human scarring process, expedited recruitment, smaller sample requirements, and greater flexibility in the types and number of interventions that can be studied simultaneously. Read More

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http://dx.doi.org/10.1089/wound.2018.0900DOI Listing

Surgical Treatment of Pyoderma Gangrenosum with Negative Pressure Wound Therapy and Skin Grafting, Including Xenografts: Personal Experience and Comprehensive Review on 161 Cases.

Adv Wound Care (New Rochelle) 2020 Apr 28. Epub 2020 Apr 28.

Department of Dermatology, Venereology and Allergology, Academic Teaching Department of Medical University Innsbruck, Central Teaching Hospital Bolzano/Bozen, Bolzano/Bozen, Italy.

Pyoderma gangrenosum (PG) is a rare debilitating autoinflammatory ulcerative skin disease. No gold standard has been established for the treatment of PG. The role of surgical interventions and negative pressure wound therapy (NPWT) was discussed controversially until recently as these procedures might pose a trigger to further aggravate the condition. Read More

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http://dx.doi.org/10.1089/wound.2020.1160DOI Listing

Improved Scar Outcomes with Increased Daily Duration of Pressure Garment Therapy.

Adv Wound Care (New Rochelle) 2020 Jun 2. Epub 2020 Jun 2.

Department of Materials Science and Engineering, The Ohio State University, Columbus, Ohio, USA.

Despite the development of a number of treatment modalities, scarring remains common postburn injury. To reduce burn scarring, pressure garment therapy has been widely utilized but is complicated by low patient adherence. To improve adherence, reduced hours of daily garment wear has been proposed. Read More

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http://dx.doi.org/10.1089/wound.2020.1161DOI Listing

Forming Nutritional and Temperature Sensitive Scaffold Improves the Esthetic Outcomes of Meshed Split-Thickness Skin Grafts in a Porcine Model.

Adv Wound Care (New Rochelle) 2020 May 28. Epub 2020 May 28.

BC Professional Firefighters' Burn and Wound Healing Research Laboratory, Department of Surgery, Division of Plastic Surgery, University of British Columbia (UBC), Vancouver, British Columbia, Canada.

Full-thickness burn wounds require immediate coverage, and the primary clinical approaches comprise of skin allografts and autografts. The use of allografts is often temporary due to the antigenicity of allografts. In contrast, the availability of skin autografts may be limited in large burn injuries. Read More

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http://dx.doi.org/10.1089/wound.2019.1108DOI Listing

The Prevalence, Characteristics, and Prevention Status of Skin Injury Caused by Personal Protective Equipment Among Medical Staff in Fighting COVID-19: A Multicenter, Cross-Sectional Study.

Adv Wound Care (New Rochelle) 2020 Apr 27. Epub 2020 Apr 27.

Wound Care Center of Outpatient Department, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

To investigate the prevalence, characteristics, and preventive status of skin injuries caused by personal protective equipment (PPE) in medical staff. A cross-sectional survey was conducted online for understanding skin injuries among medical staff fighting COVID-19 in February 8-22, 2020. Participants voluntarily answered and submitted the questionnaire with cell phone. Read More

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http://dx.doi.org/10.1089/wound.2020.1212DOI Listing

A Wound Care Specialist's Approach to Pyoderma Gangrenosum (PG).

Adv Wound Care (New Rochelle) 2020 Apr 22. Epub 2020 Apr 22.

University of Toronto Faculty of Medicine, 12366, Toronto, Ontario, Canada;

Significance: Pyoderma Gangrenosum (PG) is a rare neutrophilic ulcerative dermatosis that poses a high burden of morbidity due to underdiagnosis, resistance to therapy and limited therapeutic options. Optimization of wound care strategies and multimodal anti-inflammatory approaches are necessary to mitigate multiple converging pathways of inflammation leading to delayed healing, which is further complicated by additional factors such as pathergy.

Recent Advances: PG treatment typically involves reducing inflammation, controlling pain, promoting wound healing, and treating the underlying etiology. Read More

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http://dx.doi.org/10.1089/wound.2020.1168DOI Listing

Bioactive fatty acids in the resolution of chronic inflammation in skin wounds.

Adv Wound Care (New Rochelle) 2020 Apr 22. Epub 2020 Apr 22.

State University of Campinas, 28132, Tessalia Vieira de Camargo Street 126, Campinas, Brazil, 13083-872;

Significance: Optimal skin wound healing is crucial for maintaining tissue homeostasis, particularly in response to an injury. The skin immune system is under regulation of mediators such as bioactive lipids and cytokines that can initiate an immune response with controlled inflammation, followed by efficient resolution. However, nutritional deficiency impacts wound healing by hindering fibroblast proliferation, collagen synthesis, epithelialization, among other crucial functions. Read More

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http://dx.doi.org/10.1089/wound.2019.1105DOI Listing

Wound Size Imaging: Ready for Smart Assessment and Monitoring.

Adv Wound Care (New Rochelle) 2020 Apr 22. Epub 2020 Apr 22.

Pontificia Universidad Catolica del Peru, 42692, Medical Imaging Laboratory, Lima, Peru;

Wound assessment no longer relies only on manual measurements since optical devices can accurately capture its 3D shape and label tissues across wound bed. However, in order to be routinely used in the clinical setting, compact, user-friendly devices are preliminary requirements, before to be accepted by the nurses in charge of wound care. Low-cost wound size imaging devices now address range finding, hyperspectral resolution and thermal sensing. Read More

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http://dx.doi.org/10.1089/wound.2018.0937DOI Listing

Efficacy of Telemedicine for Patients with Chronic Wounds: A Meta-Analysis of Randomized Controlled Trials.

Adv Wound Care (New Rochelle) 2020 May 20. Epub 2020 May 20.

Nursing Department, Lingnan Branch of the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

The meta-analysis was performed to summarize the available evidence and assess the efficacy of telemedicine for patients with chronic wounds. PubMed, Embase, Web of Science, The Cochrane Library, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), WanFang, and VIP databases were electronically searched to identify eligible studies updated to February 2020 to collect randomized controlled trials regarding the efficacy of telemedicine for patients with chronic wounds. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of included studies with the Cochrane Handbook for Systematic Reviews of Interventions. Read More

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http://dx.doi.org/10.1089/wound.2020.1169DOI Listing

Include Payers in Your Product Development and Clinical Use Processes.

Adv Wound Care (New Rochelle) 2020 Apr 20. Epub 2020 Apr 20.

Kathleen D. Schaum & Associates, Inc., Lake Worth, Florida.

Wound/ulcer management scientists, researchers, manufacturers, professionals, and providers cannot assume that clearance or approval by the Food and Drug Administration (FDA) will guarantee reimbursement for medical devices they develop or wish to use in their practices. Even if a relative code and a published payment rate for the code exist, if the payers do not provide coverage for the technology, the devices may not be able to be sold and used in all settings throughout the continuum of care. Unfortunately, reimbursement (particularly coverage) is often an after-thought once FDA clearance or approval is achieved. Read More

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http://dx.doi.org/10.1089/wound.2020.1179DOI Listing

A Novel Composite Biomaterial Made of Jellyfish and Porcine Collagens Accelerates Dermal Wound Healing by Enhancing Reepithelization and Granulation Tissue Formation in Mice.

Adv Wound Care (New Rochelle) 2020 Jun 2;9(6):295-311. Epub 2019 Oct 2.

Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Japan.

Impaired dermal wound healing represents a major medical issue in today's aging populations. Granulation tissue formation in the dermis and reepithelization of the epidermis are both important and necessary for proper wound healing. Although a number of artificial dermal grafts have been used to treat full-thickness dermal loss in humans, they do not induce reepithelization of the wound, requiring subsequent epithelial transplantation. Read More

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http://dx.doi.org/10.1089/wound.2019.1014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155930PMC

A Device to Predict Short-Term Healing Outcome of Chronic Wounds.

Adv Wound Care (New Rochelle) 2020 Jun 27;9(6):312-324. Epub 2019 Dec 27.

Department of Bioengineering, University of Texas at Arlington, Arlington, Texas.

While myriads of studies have suggested that a survey of wound pH environment could indicate wound healing activities, it is not clear whether wound alkalinity can be used as a prognostic indicator of nonhealing wounds. Currently available systems cannot reliably assess the pH environment across wounds, which is the objective of this study. A disposable device, DETEC pH, was developed and characterized on its ability to map wound alkalinity by pressing a freshly recovered wound dressing against its test surface. Read More

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http://dx.doi.org/10.1089/wound.2019.1064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155926PMC

The Potential Impact of Social Genomics on Wound Healing.

Adv Wound Care (New Rochelle) 2020 Jun 21;9(6):325-331. Epub 2020 Feb 21.

Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Human skin wounds carry an immense epidemiologic and financial burden, and their impact will continue to grow with an aging population and rising incidence of comorbid conditions known to affect wound healing. To comprehensively address this growing clinical issue, physicians should also be aware of how conditions of the human social environment may affect wound healing. Here we provide a review of the emerging field of social genomics and its potential impact on the wound healing. Read More

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http://dx.doi.org/10.1089/wound.2019.1095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155927PMC

Leg Ulcers in Sickle-Cell Disease: Treatment Update.

Adv Wound Care (New Rochelle) 2020 Jun 24;9(6):348-356. Epub 2019 Apr 24.

Department of Dermatology, Tenon Hospital, Paris, France.

Sickle-cell leg ulcers (SCLUs) are a severe, chronic, and recurrent complication of sickle-cell disease (SCD). There are no official recommendations for treatment. Only a few studies with a high level of evidence have been conducted to evaluate treatment of SCLUs. Read More

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http://dx.doi.org/10.1089/wound.2018.0918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155924PMC

Heel Pressure Injuries: Consensus-Based Recommendations for Assessment and Management.

Adv Wound Care (New Rochelle) 2020 Jun 21;9(6):332-347. Epub 2019 Oct 21.

Clinica Medica, Ospedali Riuniti di Ancona, Ancona, Italy.

A systematic approach to develop experts-based recommendations could have a favorable impact on clinical problems characterized by scarce and low-quality evidence as heel pressure ulcers. A systematic approach was used to conduce a formal consensus initiative. A multidisciplinary panel of experts identified relevant clinical questions, performed a systematic search of the literature, and created a list of statements. Read More

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http://dx.doi.org/10.1089/wound.2019.1042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155923PMC

Comprehensive Proteomic Profiling of Pressure Ulcers in Patients with Spinal Cord Injury Identifies a Specific Protein Pattern of Pathology.

Adv Wound Care (New Rochelle) 2020 05 19;9(5):277-294. Epub 2020 Mar 19.

Department of Vascular Physiopathology, National Hospital for Paraplegics (HNP), SESCAM, Toledo, Spain.

Severe pressure ulcers (PUs) do not respond to conservative wound therapy and need surgical repair. To better understand the pathogenesis and to advance on new therapeutic options, we focused on the proteomic analysis of PU, which offers substantial opportunities to identify significant changes in protein abundance during the course of PU formation in an unbiased manner. To better define the protein pattern of this pathology, we performed a proteomic approach in which we compare severe PU tissue from spinal cord injury (SCI) patients with control tissue from the same patients. Read More

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http://dx.doi.org/10.1089/wound.2019.0968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099418PMC

Treatment of Full-Thickness Skin Wounds with Blood-Derived CD34 Precursor Cells Enhances Healing with Hair Follicle Regeneration.

Adv Wound Care (New Rochelle) 2020 05 19;9(5):264-276. Epub 2020 Mar 19.

Division of Plastic Surgery, Department of Surgery, School of Medicine, Stanford University, Stanford, California.

Epidermal CD34 stem cells located in the hair follicle (HF) bulge area are capable of inducing HF neogenesis and enhancing wound healing after transplantation. In this study, we observed CD34 cells derived from blood directly participate in dermal regeneration during full-thickness excisional wound healing. We isolated and expanded a subset of hematopoietic stem cell (HSC)-like precursor cells from the peripheral blood of adult mice with the surface markers: CD34, leucine rich repeat containing G protein-coupled receptor 5 (LGR5), CD44, c-kit, lineage negative (lin), and E-cadherin. Read More

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http://dx.doi.org/10.1089/wound.2019.0974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099428PMC

Imaging in Chronic Wound Diagnostics.

Adv Wound Care (New Rochelle) 2020 05 19;9(5):245-263. Epub 2020 Mar 19.

Department of Bioengineering, University of Texas at Arlington, Arlington, Texas.

Chronic wounds affect millions of patients worldwide, placing a huge burden on health care resources. Although significant progress has been made in the development of wound treatments, very few advances have been made in wound diagnosis. Standard imaging methods like computed tomography, single-photon emission computed tomography, magnetic resonance imaging, terahertz imaging, and ultrasound imaging have been widely employed in wound diagnostics. Read More

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http://dx.doi.org/10.1089/wound.2019.0967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099416PMC

Suppressor of Fused Inhibits Skin Wound Healing.

Adv Wound Care (New Rochelle) 2020 05 19;9(5):233-244. Epub 2020 Mar 19.

Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

To investigate the effect of suppressor of fused (Sufu) on epidermal and dermal cellular properties and in wound healing. Transgenic (TG) mice overexpressing human Sufu (hSufu) in the epidermis were applied to investigate the effects of Sufu on epidermal and dermal cellular properties and in wound healing. Histological staining revealed a reduction of epidermal and dermal thickness and an increase of hypodermal adipose tissue in homozygous K14-hSufu TG mice when compared with wild-type (WT) controls. Read More

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http://dx.doi.org/10.1089/wound.2018.0890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099415PMC

Inhibition of GKN2 Attenuates Acute Gastric Lesions Through the NLRP3 Inflammasome.

Adv Wound Care (New Rochelle) 2020 05 19;9(5):219-232. Epub 2020 Mar 19.

Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, P.R. China.

Acute gastric lesions are commonly seen in critically ill patients in the intensive care unit and can result in significant upper gastrointestinal bleeding. However, the signaling mechanisms that regulate this severe disease are still unclear. In this study, we explored the involvement of gastrokine 2 (GKN2) in the development of acute gastric lesions in mice. Read More

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http://dx.doi.org/10.1089/wound.2019.0957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099419PMC

The Use of a Fixation Dressing to Reduce Complications After Neonatal Gastrostomy Tube Placement.

Adv Wound Care (New Rochelle) 2020 05 19;9(5):211-218. Epub 2020 Mar 19.

Laboratory for Regenerative Tissue Repair, Texas Children's Hospital, Houston, Texas.

Gastrostomy tubes (GTs) are one of the most common procedures in neonatal surgery, and their malfunction represents one of the most common complaints in the emergency room and clinic. Complications can occur in up to one-third of patients and include pain, peristomal leak, and infection, but can range in severity. We hypothesize that a preventative strategy employing a GT fixation dressing at the time of operation minimizes these postoperative complications in neonates. Read More

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http://dx.doi.org/10.1089/wound.2019.0999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099412PMC

Clinical Study of Nanofibrillar Cellulose Hydrogel Dressing for Skin Graft Donor Site Treatment.

Adv Wound Care (New Rochelle) 2020 04 7;9(4):199-210. Epub 2020 Feb 7.

Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

Skin graft donor site management is a concern particularly for elderly patients and patients with poor wound healing competence, and also because donor sites are a source of pain and discomfort. Although different types of dressings exist, there is no consensus regarding optimal dressing type on donor site care to promote healing, reduce pain, and improve patients' comfort. This prospective, single-center clinical trial evaluated the performance of nanofibrillar cellulose (NFC) wound dressing (FibDex by UPM-Kymmene Corporation) for treatment of donor sites compared with a polylactide-based copolymer dressing. Read More

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http://dx.doi.org/10.1089/wound.2019.0982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047117PMC

The Role of the Anti-Inflammatory Cytokine Interleukin-10 in Tissue Fibrosis.

Adv Wound Care (New Rochelle) 2020 04 7;9(4):184-198. Epub 2020 Feb 7.

Department of Surgery, Baylor College of Medicine, Houston, Texas.

Fibrosis is the endpoint of chronic disease in multiple organs, including the skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue results in a loss of structural integrity and function, with resultant increases in morbidity and mortality. Understanding the pathways governing fibrosis and identifying therapeutic targets within those pathways is necessary to develop novel antifibrotic therapies for fibrotic disease. Read More

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http://dx.doi.org/10.1089/wound.2019.1032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047112PMC

Skin Microcolumns as a Source of Paracrine Signaling Factors.

Adv Wound Care (New Rochelle) 2020 04 7;9(4):174-183. Epub 2020 Feb 7.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.

We recently developed the approach of using "microcolumns" of autologous full-thickness skin tissue for wound repair. The small size of these micro skin tissue columns (MSTCs, ∼0.5 mm in diameter) allows donor sites to heal quickly without scarring. Read More

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http://dx.doi.org/10.1089/wound.2019.1045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047113PMC

Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair.

Adv Wound Care (New Rochelle) 2020 04 7;9(4):161-173. Epub 2020 Feb 7.

Regenerative Medicine, Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia.

Activation of epidermal stem cells (EpSCs) from their quiescent niche is an integral component of wound reepithelialization and involves Wnt/β-catenin (β-Cat) signaling and remodeling of the actin cytoskeleton. The aim of this study was to investigate the effect of Flightless I (Flii), a cytoskeletal protein and inhibitor of wound healing, on EpSC activation during wound repair. Genetically modified Flii mice ( knockdown: , wild type: WT, overexpressing: ) received two incisional wounds along the lateral axis of the dorsal skin. Read More

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http://dx.doi.org/10.1089/wound.2018.0884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047082PMC

Circular RNA hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation.

Adv Wound Care (New Rochelle) 2020 04 7;9(4):145-160. Epub 2020 Feb 7.

Dermatology and Venereology Unit, Department of Medicine (Solna), Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Insufficient knowledge about the molecular pathology of diabetic foot ulcer (DFU) impedes the development of effective wound treatment. Circular RNAs (circRNAs) are a novel class of RNA recently discovered to be widely expressed and have important biological functions; however, their role in skin wound healing remains largely unexplored. In this study, we investigated the role of circRNAs in DFU. Read More

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http://dx.doi.org/10.1089/wound.2019.0956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047102PMC

Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging.

Adv Wound Care (New Rochelle) 2020 03 24;9(3):127-143. Epub 2020 Jan 24.

Department of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas.

Chronic wounds, such as diabetic foot ulcers, venous stasis ulcers, and pressure ulcers affect millions of Americans each year, and disproportionately afflict our increasingly older population. Older individuals are predisposed to wound infection, repeated trauma, and the development of chronic wounds. However, a complete understanding of how the attributes of aging skin affect the wound healing process has remained elusive. Read More

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http://dx.doi.org/10.1089/wound.2019.1021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985772PMC

Impaired Neovascularization in Aging.

Adv Wound Care (New Rochelle) 2020 03 24;9(3):111-126. Epub 2020 Jan 24.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University, Stanford, California.

The skin undergoes an inevitable degeneration as an individual ages. As intrinsic and extrinsic factors degrade the structural integrity of the skin, it experiences a critical loss of function and homeostatic stability. Thus, aged skin becomes increasingly susceptible to injury and displays a prolonged healing process. Read More

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http://dx.doi.org/10.1089/wound.2018.0912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985771PMC

SPECT/CT Imaging: A Noninvasive Approach for Evaluating Serial Changes in Angiosome Foot Perfusion in Critical Limb Ischemia.

Adv Wound Care (New Rochelle) 2020 03 24;9(3):103-110. Epub 2020 Jan 24.

The Center for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

To investigate the feasibility of serial radiotracer-based imaging as a noninvasive approach for quantifying volumetric changes in microvascular perfusion within angiosomes of the foot following lower extremity revascularization in the setting of critical limb ischemia (CLI). A CLI patient with a nonhealing foot ulcer underwent single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging of the feet before and after balloon angioplasty of the superficial femoral artery (SFA) and popliteal artery. SPECT/CT imaging was used to evaluate serial changes in angiosome perfusion, which was compared to quantitative changes in peripheral vascular anatomy and hemodynamics, as assessed by standard clinical tools that included digital subtraction angiography (DSA), ankle-brachial index (ABI), and toe-brachial index (TBI). Read More

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http://dx.doi.org/10.1089/wound.2018.0924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985768PMC

Quantifying Age-Related Changes in Skin Wound Metabolism Using Multiphoton Microscopy.

Adv Wound Care (New Rochelle) 2020 03 24;9(3):90-102. Epub 2020 Jan 24.

Department of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas.

The elderly are at high risk for developing chronic skin wounds, but the effects of intrinsic aging on skin healing are difficult to isolate due to common comorbidities like diabetes. Our objective is to use multiphoton microscopy (MPM) to find endogenous, noninvasive biomarkers to differentiate changes in skin wound healing metabolism between young and aged mice . We utilized MPM to monitor skin metabolism at the edge of full-thickness, excisional wounds in 24- and 4-month-old mice of both sexes for 10 days. Read More

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http://dx.doi.org/10.1089/wound.2019.1030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985773PMC

Skin Biomechanics and miRNA Expression Following Chronic UVB Irradiation.

Adv Wound Care (New Rochelle) 2020 03 24;9(3):79-89. Epub 2020 Jan 24.

Department of Materials Science and Engineering, The Ohio State University, Columbus, Ohio.

Exposure to ultraviolet (UV) light from the sun is known to accelerate the skin aging process and leads to significant alterations in skin biomechanics; however, the molecular mechanisms by which chronic UVB affects biomechanical properties of the skin have not been well described. A murine model for chronic UVB exposure was used to examine changes in epidermal barrier function, skin biomechanics, and miRNA expression as a result of UVB. UVB irradiation caused skin to be weaker, less elastic, stiffer, and less pliable. Read More

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http://dx.doi.org/10.1089/wound.2019.1034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985774PMC

The Wound Healing Index for Predicting Venous Leg Ulcer Outcome.

Adv Wound Care (New Rochelle) 2020 02 18;9(2):68-77. Epub 2019 Dec 18.

International Severity Information Systems, Inc., Salt Lake City, Utah.

To develop a venous leg ulcer (VLU) risk stratification system for use in research and clinical practice. U.S. Read More

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http://dx.doi.org/10.1089/wound.2019.1038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940587PMC
February 2020

Wound Conforming Matrix Containing Purified Homogenate of Dermal Collagen Promotes Healing of Diabetic Neuropathic Foot Ulcers: Comparative Analysis Versus Standard of Care.

Adv Wound Care (New Rochelle) 2020 02 18;9(2):61-67. Epub 2019 Dec 18.

Division of Vascular Surgery, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

To compare outcomes of diabetic foot ulcers (DFUs) treated with a collagen Wound Conforming Matrix (WCM) or standard of care (SOC). WCM, a highly purified homogenate of 2.6% fibrillar bovine dermal collagen that conforms to the wound surface, was evaluated in comparison to daily saline-moistened gauze dressing changes (SOC) as part of a retrospective subset analysis of a randomized controlled trial in DFU. Read More

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http://dx.doi.org/10.1089/wound.2019.1024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940589PMC
February 2020

Immediate Treatment of Burn Wounds with High Concentrations of Topical Antibiotics in an Alginate Hydrogel Using a Platform Wound Device.

Adv Wound Care (New Rochelle) 2020 02 18;9(2):48-60. Epub 2019 Dec 18.

Applied Tissue Technologies LLC, Hingham, Massachusetts.

There is an unmet need to improve immediate burn care, particularly when definitive treatment is delayed. Therefore, the purpose of this project was to formulate a hydrogel that contains very high concentrations of antibiotics and validate its use together with a platform wound device (PWD) for the immediate care of burns. The hydrogel properties were optimized by using a rheometer, differential scanning calorimetry, and liquid chromatography-mass spectrometry and were tested in an infected porcine burn model. Read More

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http://dx.doi.org/10.1089/wound.2019.1018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940590PMC
February 2020

The Immune Response to Chronic Wound Infection in Immunocompetent Mice.

Adv Wound Care (New Rochelle) 2020 02 18;9(2):35-47. Epub 2019 Dec 18.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, California.

Our goal was to develop a chronic wound model in mice that avoids implantation of foreign material or impaired immunity and to use this to characterize the local and systemic immune response associated with infection. We generated bilateral full-thickness dermal wounds in healthy 10-12-week-old C57Bl6 mice. We waited 24 h to inoculate the developing wound eschar at these sites. Read More

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http://dx.doi.org/10.1089/wound.2019.1039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940591PMC
February 2020

Pressure Ulcer Monitoring Platform-A Prospective, Human Subject Clinical Study to Validate Patient Repositioning Monitoring Device to Prevent Pressure Ulcers.

Adv Wound Care (New Rochelle) 2020 01 6;9(1):28-33. Epub 2019 Dec 6.

Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.

The objective of this prospective clinical study was to validate two prototype pressure ulcer monitoring platform (PUMP) devices, (PUMP1 and PUMP2), to promote optimal bed repositioning of hospitalized patients to prevent pressure ulcers (PUs). PUMP1 was a wearable electronic device attached to the patient gown with no skin contact. PUMP2 was a set of four identical electronic devices placed under the patient's bed wheels. Read More

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http://dx.doi.org/10.1089/wound.2018.0934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922059PMC
January 2020

Neutrophil Extracellular Traps Are Markers of Wound Healing Impairment in Patients with Diabetic Foot Ulcers Treated in a Multidisciplinary Setting.

Adv Wound Care (New Rochelle) 2020 01 6;9(1):16-27. Epub 2019 Dec 6.

Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. China.

Neutrophil extracellular traps (NETs) are associated with impaired wound healing in diabetes. This study evaluates the association between NET-specific markers and wound healing among diabetic foot ulcer (DFU) patients treated in a multidisciplinary setting. Clinical data of diabetic patients with active foot ulcers who presented to our team between January 1, 2016 and June 30, 2017 were recorded. Read More

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http://dx.doi.org/10.1089/wound.2019.0943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918858PMC
January 2020