654 results match your criteria Advances in wound care[Journal]


Effect of a Single Injection of Benidipine-Impregnated Biodegradable Microcarriers on Bone and Gingival Healing at the Tooth Extraction Socket.

Adv Wound Care (New Rochelle) 2019 Mar 5;8(3):108-117. Epub 2019 Mar 5.

Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

A dihydropyridine-type calcium channel blocker, benidipine (BD), is extensively used in hypertension therapy. study reported BD promoting bone metabolism. We evaluated the effect of sustained release of BD-loaded poly(lactic-co-glycolic acid) (PLGA) microcarriers on the promotion of bone and gingival healing at an extraction socket . Read More

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http://dx.doi.org/10.1089/wound.2018.0834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430984PMC
March 2019
1 Read

Honey-Based Salve and Burdock Leaf Dressings as an Alternative to Surgical Debridement of a Traumatic Wound Eschar.

Adv Wound Care (New Rochelle) 2019 Mar 5;8(3):101-107. Epub 2019 Mar 5.

Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio.

Nonviable necrotic eschar is an impedance to wound healing and can ultimately lead to failure of soft tissue coverage in traumatic or high-risk wounds. Topical therapeutic agents can provide a less invasive management alternative to surgical debridement of eschar. The case of a 40-year-old male with a traumatic right lower extremity amputation complicated by surgical incision ischemic eschar formation is reported. Read More

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http://dx.doi.org/10.1089/wound.2018.0806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430982PMC

Fidgetin-Like 2 siRNA Enhances the Wound Healing Capability of a Surfactant Polymer Dressing.

Adv Wound Care (New Rochelle) 2019 Mar 5;8(3):91-100. Epub 2019 Mar 5.

MicroCures, Inc., Research and Development, Bronx, New York.

Microtubules (MTs) are intracellular polymers that provide structure to the cell, serve as railways for intracellular transport, and regulate many cellular activities, including cell migration. The dynamicity and function of the MT cytoskeleton are determined in large part by its regulatory proteins, including the recently discovered MT severing enzyme Fidgetin-like 2 (FL2). Downregulation of FL2 expression with small interfering RNA (siRNA) results in a more than twofold increase in cell migration rate as well as translates into improved wound-healing outcomes in mouse models. Read More

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https://www.liebertpub.com/doi/10.1089/wound.2018.0827
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http://dx.doi.org/10.1089/wound.2018.0827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430983PMC
March 2019
4 Reads

Three Years' Experience of a Novel Biosynthetic Cellulose Dressing in Burns.

Adv Wound Care (New Rochelle) 2019 Feb 13;8(2):71-76. Epub 2019 Feb 13.

Department of Plastic Surgery, Hand Surgery, and Burns, Linköping University, Linköping, Sweden.

The use of porcine xenograft (PX) is widely spread in burn care. However, it may cause immunologic responses and other ethical and cultural considerations in different cultures. Therefore, there is a need for alternatives. Read More

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http://dx.doi.org/10.1089/wound.2018.0790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389762PMC
February 2019
3 Reads

A Single Center Retrospective Evaluation of a Surgical Strategy to Combat Persistent Soft Tissue Wounds Utilizing Absorbable Antibiotic Beads.

Adv Wound Care (New Rochelle) 2019 Feb 13;8(2):49-57. Epub 2019 Feb 13.

Division of Plastic Surgery, University of New Mexico Hospital, Albuquerque, New Mexico.

To determine whether use of absorbable antibiotic-imbued beads in chronic soft tissue wounds presents a viable therapeutic modality. Retrospective analysis of all cases utilizing calcium sulfate antibiotic beads was conducted. Cases comprised complex wound and breast reconstruction performed by the senior author (C. Read More

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http://dx.doi.org/10.1089/wound.2018.0795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389768PMC
February 2019
1 Read

Human Wounds and Its Burden: An Updated Compendium of Estimates.

Authors:
Chandan K Sen

Adv Wound Care (New Rochelle) 2019 Feb 13;8(2):39-48. Epub 2019 Feb 13.

Department of Surgery, Indiana University Health Comprehensive Wound Center, Indianapolis, Indiana.

A 2018 retrospective analysis of Medicare beneficiaries identified that ∼8.2 million people had wounds with or without infections. Medicare cost estimates for acute and chronic wound treatments ranged from $28. Read More

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http://dx.doi.org/10.1089/wound.2019.0946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389759PMC
February 2019
3 Reads

Wound Healing Activity of Plants from the Convolvulaceae Family.

Adv Wound Care (New Rochelle) 2019 Jan 5;8(1):28-37. Epub 2019 Jan 5.

Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Cochin, India.

Compounds derived from plants are gaining importance for the treatment of several diseases. Many plants from the Convolvulaceae family contain compounds that have demonstrated wound healing and antidiabetic activity. Such compounds can be effectively used as a part of treatments to promote wound healing in diabetics and used in combination with antimicrobial therapy to reduce the likelihood of drug resistance and allergic reactions. Read More

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https://www.liebertpub.com/doi/10.1089/wound.2017.0781
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http://dx.doi.org/10.1089/wound.2017.0781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350056PMC
January 2019
10 Reads

A Porcine Wound Model of Infection.

Adv Wound Care (New Rochelle) 2019 Jan 5;8(1):14-27. Epub 2019 Jan 5.

Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland.

To better understand pathogenesis and to advance drug discovery against this pathogen, we developed a porcine, full-thickness, excisional, monospecies infection wound model. The research was facilitated with AB5075, a previously characterized, extensively drug-resistant . isolate. Read More

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http://dx.doi.org/10.1089/wound.2018.0786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350066PMC
January 2019
9 Reads

Comparison of Fractional CO Laser, Verapamil, and Triamcinolone for the Treatment of Keloid.

Adv Wound Care (New Rochelle) 2019 Jan 5;8(1):7-13. Epub 2019 Jan 5.

Department of Plastic Surgery, Sawai Man Singh Medical College and Hospital, Rajasthan University of Health Sciences, Jaipur, India.

Scar biology is a territory less understood. The search for ideal treatment of keloid continues. The aim of this study was to compare the role of CO laser, triamcinolone (TAC), and verapamil in the treatment of keloid. Read More

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http://dx.doi.org/10.1089/wound.2018.0798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350054PMC
January 2019

Prediction of In-Hospital Pressure Ulcer Development.

Adv Wound Care (New Rochelle) 2019 Jan 5;8(1):1-6. Epub 2019 Jan 5.

Department of Endocrinology and Internal Medicine, Medical Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.

The development of in-hospital acquired pressure ulcers (PUs) is of great concern for both patients and professionals in health care. Based on the hypothesis that identification of patients who are prone to develop PU will enhance preventive measures in this group of patients, we investigated a new tool, Qscale, for in-hospital prediction of PU. A total of 383 patients were recruited from three departments. Read More

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http://dx.doi.org/10.1089/wound.2018.0803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350059PMC
January 2019
2 Reads

Impact of Hyperbaric Oxygen on More Advanced Wagner Grades 3 and 4 Diabetic Foot Ulcers: Matching Therapy to Specific Wound Conditions.

Adv Wound Care (New Rochelle) 2018 Dec 20;7(12):397-407. Epub 2018 Dec 20.

Research and Informatics, Healogics, Inc., Jacksonville, Florida.

The goal of this research was to identify a population of diabetic foot ulcer patients who demonstrate a significant response to hyperbaric oxygen therapy (HBOT) using a large sample size to provide guidance for clinicians when treating these complicated patients. The effect of HBOT on diabetic foot ulcers, Wagner grades 3 and 4, was evaluated using a retrospective observational real-world data set. The study reported on the overall healing rate, (74. Read More

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https://www.liebertpub.com/doi/10.1089/wound.2018.0855
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http://dx.doi.org/10.1089/wound.2018.0855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338555PMC
December 2018
11 Reads

Evidence for Polymeric Membrane Dressings as a Unique Dressing Subcategory, Using Pressure Ulcers as an Example.

Authors:
Linda L Benskin

Adv Wound Care (New Rochelle) 2018 Dec 8;7(12):419-426. Epub 2018 Dec 8.

Independent Nurse Researcher, for Wound Care in Rural Areas of Tropical Developing Countries, and Clinical Research & Education Liaison, Charity Liaison for Ferris Mfg. Corp., Austin, Texas.

Wound management recommendations usually group dressings by base substrate material or reimbursement codes, even when functional differences are vast (., honey-containing alginates, super-absorbent hydrogels). Polymeric membrane dressings (PMDs) diverge dramatically from conventional foam dressings in functional attributes, indications, and patient results, providing an opportunity to demonstrate the evidence for categorizing dressings based upon functional differences. Read More

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http://dx.doi.org/10.1089/wound.2018.0822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306668PMC
December 2018
2 Reads

Health Economics and Outcomes Research of Wound Care: Overview of Methodology.

Adv Wound Care (New Rochelle) 2018 Nov 12;7(11):380-386. Epub 2018 Nov 12.

Vector Oncology, Rosenberg, Texas.

To provide an overview of comparative effectiveness research (CER) methodology and discuss the challenges of health economics and outcomes research (HEOR) in wound care. Narrative description of HEOR methodology with supporting references. With the increasing costs of clinical trials, the use of observational studies in a real-world setting will be essential. Read More

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https://www.liebertpub.com/doi/10.1089/wound.2018.0817
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http://dx.doi.org/10.1089/wound.2018.0817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247976PMC
November 2018
11 Reads

Clinical Outcomes for Diabetic Foot Ulcers Treated with Clostridial Collagenase Ointment or with a Product Containing Silver.

Adv Wound Care (New Rochelle) 2018 Oct 11;7(10):339-348. Epub 2018 Oct 11.

Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, Texas.

To compare outcomes of diabetic foot ulcers (DFUs) treated with clostridial collagenase ointment (CCO) or silver-containing products, both in combination with sharp debridement as needed. One hundred two subjects with qualifying DFUs were randomized to daily treatment with either CCO or a silver-containing product for 6 weeks followed by a 4 -week follow-up period. The primary outcome was the mean percent reduction in DFU area. Read More

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https://www.liebertpub.com/doi/10.1089/wound.2018.0784
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http://dx.doi.org/10.1089/wound.2018.0784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203225PMC
October 2018
3 Reads

Instillation Negative Pressure Wound Therapy: An Effective Tool for Complex Spine Wounds.

Adv Wound Care (New Rochelle) 2018 Oct 11;7(10):333-338. Epub 2018 Oct 11.

Department of Plastic Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Infection prevention in spinal surgeries involving implantation of hardware is of utmost priority. Furthermore, successful eradication of infection in hardware salvage is likewise critical in maintaining the long-term retention of the spinal hardware construct. We report a retrospective case series of three cases where the utilization of a VAC with instillation (VACi) in conjunction with surgical debridement aided in infection control and eradication for both preimplantation and hardware salvage spine patients. Read More

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https://www.liebertpub.com/doi/10.1089/wound.2018.0793
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http://dx.doi.org/10.1089/wound.2018.0793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203227PMC
October 2018
6 Reads

Iron Chelation with Transdermal Deferoxamine Accelerates Healing of Murine Sickle Cell Ulcers.

Adv Wound Care (New Rochelle) 2018 Oct 11;7(10):323-332. Epub 2018 Oct 11.

Department of Surgery, Stanford University School of Medicine, Stanford, California.

Sickle cell ulcers (SCUs) are a devastating comorbidity affecting patients with sickle cell disease (SCD). SCUs form over the medial or lateral malleoli of the lower extremity, are slow to heal, and prone to recidivism. Some SCUs may never heal, leading to chronic pain and foot deformities. Read More

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https://www.liebertpub.com/doi/10.1089/wound.2018.0789
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http://dx.doi.org/10.1089/wound.2018.0789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203233PMC
October 2018
2 Reads

Efficacy of Concentrated Surfactant-Based Wound Dressings in Wound Repair and Biofilm Reduction.

Adv Wound Care (New Rochelle) 2018 Sep 4;7(9):315-322. Epub 2018 Sep 4.

5D Health Protection Group Ltd., Centre of Excellence in Biofilm Science (CEBS), Liverpool Bio-Innovation Hub, Liverpool, United Kingdom.

This study was set up to evaluate the efficacy of a concentrated surfactant-based wound dressing (with and without silver sulfadiazine [SSD]) on wound repair, by investigating their ability to enhance human dermal fibroblast proliferation and viability. In addition, the wound dressings were evaluated for their ability to suppress biofilms in a three-dimensional (3D) wound biofilm model and modulate the inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα). Problematic biofilms are well known to affect fibroblast and keratinocyte viability. Read More

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https://www.liebertpub.com/doi/10.1089/wound.2017.0782
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http://dx.doi.org/10.1089/wound.2017.0782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156693PMC
September 2018
6 Reads

Evaluation of Donor Site Pain After Fractional Autologous Full-Thickness Skin Grafting.

Adv Wound Care (New Rochelle) 2018 Sep 4;7(9):309-314. Epub 2018 Sep 4.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Despite the development of numerous wound treatment alternatives, 25% to 50% of leg ulcers and >30% of foot ulcers are not fully healed after 6 months of treatment. Autologous skin grafting is a time-tested therapy for these wounds; however, the creation of a new wound in the donor area yields a considerable limitation to this procedure. Fractional autologous full-thickness skin grafting (FFTSG) is a technique wherein multiple small full-thickness skin grafts (FTSGs) are harvested with possibly minor donor-site comorbidities. Read More

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http://dx.doi.org/10.1089/wound.2018.0800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156689PMC
September 2018

Human Adipose-Derived Stem Cell Conditioned Media and Exosomes Containing Promote Human Dermal Fibroblast Migration and Ischemic Wound Healing.

Adv Wound Care (New Rochelle) 2018 Sep 4;7(9):299-308. Epub 2018 Sep 4.

Research Service, James A. Haley Veterans Hospital, Tampa, Florida.

Chronically ill patients heal recalcitrant ulcerative wounds more slowly. Human adipose-derived stem cells (hADSCs) play an important role in tissue regeneration and exosomes secreted by hADSC contribute to their paracrine signaling. In addition to cytokines, lipids and growth factors, hADSC secrete mRNA, miRNA, and long noncoding (lnc) RNA into exosomes. Read More

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http://dx.doi.org/10.1089/wound.2017.0775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158770PMC
September 2018
2 Reads

VEGF Receptor-2 Activation Mediated by VEGF-E Limits Scar Tissue Formation Following Cutaneous Injury.

Adv Wound Care (New Rochelle) 2018 Aug;7(8):283-297

Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.

Vascular endothelial growth factor (VEGF) family members are critical regulators of tissue repair and depending on their distinct pattern of receptor specificity can also promote inflammation and scarring. This study utilized a receptor-selective VEGF to examine the role of VEGF receptor (VEGFR)-2 in scar tissue (ST) formation. Cutaneous skin wounds were created in mice using a 4 mm biopsy punch and then treated until closure with purified VEGF-E derived from orf virus stain NZ-2. Read More

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http://dx.doi.org/10.1089/wound.2016.0721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080089PMC

Use of a National Electronic Health Record Network to Describe Characteristics and Healing Patterns of Sickle Cell Ulcers.

Adv Wound Care (New Rochelle) 2018 Aug;7(8):276-282

Division of Hematology, Montefiore Medical Center, Bronx, New York.

Sickle cell ulcers affect as many as 15% of patients with sickle cell disease in the United States and severely impact quality of life. An understanding of baseline healing patterns is important to inform study design for future trials that test therapies for this disease. In this study, an electronic wound management system was leveraged to analyze retrospective data on 133 unique sickle cell patients who were treated across 114 wound healing centers, and to describe their characteristics and healing patterns as compared with those of venous ulcer patients. Read More

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http://dx.doi.org/10.1089/wound.2018.0788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080109PMC
August 2018
9 Reads

Pathway Analysis of Gene Expression in Murine Fetal and Adult Wounds.

Adv Wound Care (New Rochelle) 2018 Aug;7(8):262-275

Division of Plastic Surgery, Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University School of Medicine, Stanford, California.

In early gestation, fetal wounds heal without fibrosis in a process resembling regeneration. Elucidating this remarkable mechanism can result in tremendous benefits to prevent scarring. Fetal mouse cutaneous wounds before embryonic day (E)18 heal without scar. Read More

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http://www.liebertpub.com/doi/10.1089/wound.2017.0779
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http://dx.doi.org/10.1089/wound.2017.0779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080120PMC
August 2018
3 Reads

Wound Healing Research at the Hagey Laboratory for Pediatric Regenerative Medicine at Stanford University School of Medicine.

Adv Wound Care (New Rochelle) 2018 Aug;7(8):257-261

Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California.

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http://www.liebertpub.com/doi/10.1089/wound.2018.0787
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http://dx.doi.org/10.1089/wound.2018.0787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080091PMC
August 2018
3 Reads

Fungi in the Wound Microbiome.

Adv Wound Care (New Rochelle) 2018 Jul;7(7):247-255

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Culture-independent methods have revealed the diverse and dynamic bacterial communities that colonize chronic wounds. Only recently have studies begun to examine fungal colonization and interactions with the bacterial component of the microbiome, their relationship with the host, and influence on wound outcomes. Studies using culture-independent sequencing methods reveal that fungi often go undetected in wounds. Read More

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http://dx.doi.org/10.1089/wound.2017.0756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032664PMC
July 2018
22 Reads

Inspired by Nature: Hydrogels as Versatile Tools for Vascular Engineering.

Adv Wound Care (New Rochelle) 2018 Jul;7(7):232-246

Department of Obstetrics, University and University Hospital Zurich, Zurich, Switzerland.

Diseases related to vascular malfunction, hyper-vascularization, or lack of vascularization are among the leading causes of morbidity and mortality. Engineered, vascularized tissues as well as angiogenic growth factor-releasing hydrogels could replace defective tissues. Further, treatments and testing of novel vascular therapeutics will benefit significantly from models that allow for the study of vascularized tissues under physiological relevant conditions. Read More

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http://dx.doi.org/10.1089/wound.2017.0760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032659PMC
July 2018
1 Read

Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets.

Adv Wound Care (New Rochelle) 2018 Jul;7(7):209-231

European Molecular Biology Laboratory Australia, Australian Regenerative Medicine Institute, Monash University, Victoria, Australia.

The immune system plays a central role in orchestrating the tissue healing process. Hence, controlling the immune system to promote tissue repair and regeneration is an attractive approach when designing regenerative strategies. This review discusses the pathophysiology of both acute and chronic wounds and possible strategies to control the immune system to accelerate chronic wound closure and promote skin regeneration (scar-less healing) of acute wounds. Read More

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http://dx.doi.org/10.1089/wound.2017.0761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032665PMC
July 2018
1 Read

Physiological Perspective on Therapies of Lymphatic Vessels.

Adv Wound Care (New Rochelle) 2018 Jul;7(7):189-208

Institute for Molecular Engineering, The University of Chicago, Chicago, Illinois.

Growth of distinctive blood vessels of granulation tissue is a central step in the post-developmental tissue remodeling. Even though lymphangiogenesis is a part of the regeneration process, the significance of the controlled restoration of lymphatic vessels has only recently been recognized. Identification of lymphatic markers and growth factors paved the way for the exploration of the roles of lymphatic vessels in health and disease. Read More

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http://dx.doi.org/10.1089/wound.2017.0768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032671PMC
July 2018
1 Read

The Relationship of Wound Healing with Psoriasis and Multiple Sclerosis.

Authors:
Vera B Morhenn

Adv Wound Care (New Rochelle) 2018 Jun;7(6):185-188

Department of Dermatology, San Francisco VA Medical Center, San Francisco, California.

Better understanding of wound healing could lead to improved treatment(s) of multiple sclerosis (MS) and psoriasis (Pso). New concepts in the events of wound healing, such as the roles of the innate and adaptive immune systems, have generated targets for treating these debilitating diseases. That in MS and Pso defective wound healing is responsible for the diseases' progression has not been hypothesized to date. Read More

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http://dx.doi.org/10.1089/wound.2017.0773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994149PMC
June 2018
5 Reads

Comparing the Tolerability of a Novel Wound Closure Device Using a Porcine Wound Model.

Adv Wound Care (New Rochelle) 2018 Jun;7(6):177-184

JULVIA™ Technologies, Inc., Corvallis, Oregon.

To compare the tolerability and mechanical tensile strength of acute skin wounds closed with nylon suture plus a novel suture bridge device (SBD) with acute skin wounds closed with nylon suture in a porcine model. Four Yucatan pigs each received 12 4.5 cm full-thickness incisions that were closed with 1 of 4 options: Suture bridge with nylon, suture bridge with nylon and subdermal polyglactin, nylon simple interrupted, and nylon simple interrupted with subdermal polyglactin. Read More

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http://dx.doi.org/10.1089/wound.2017.0777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994150PMC
June 2018
2 Reads

Recurrence of Critical Limb Ischemia After Endovascular Intervention in Patients with Diabetic Foot Ulcers.

Adv Wound Care (New Rochelle) 2018 Jun;7(6):171-176

Department of Systems Medicine, University of Tor Vergata, Rome, Italy.

To establish the rate of clinical recurrence of critical limb ischemia (CLI) in diabetic patients with ischemic foot ulcers (DFUs) treated by percutaneous transluminal angioplasty (PTA). The study group was composed of 304 patients with ischemic DFUs treated by PTA. We evaluated the rate of clinical recurrence of CLI requiring a second PTA (repeated PTA [rePTA]), the factors related to CLI relapse, and the outcomes of rePTA patients. Read More

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http://dx.doi.org/10.1089/wound.2017.0778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994148PMC
June 2018
19 Reads

High-Frequency Generator in Wound Healing of Marjolin's Ulcer After Carcinoma Resection.

Adv Wound Care (New Rochelle) 2018 May;7(5):165-170

Physical Therapy Department, Federal University of Sao Carlos (UFSCAR), Sao Paulo, Brazil.

Marjolin's ulcers (MU) are skin malignancies that form over burn injuries. These very aggressive ulcers can result in functional and wound healing impairment, and require a well thought out treatment plan. Physiotherapy offers resources to help promote recovery of these patients, as described in this case report, in which the patient with a history of burn in the lower limbs evolved to malignancy 32 years later. Read More

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http://dx.doi.org/10.1089/wound.2017.0757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946735PMC

A Comparison of Three Methods for the Analysis of Skin Flap Viability: Reliability and Validity.

Adv Wound Care (New Rochelle) 2018 May;7(5):157-163

Departamento de Fisioterapia, Universidade Federal de São Carlos, São Carlos, São Paulo, Brazil.

Technological advances have provided new alternatives to the analysis of skin flap viability in animal models; however, the interrater validity and reliability of these techniques have yet to be analyzed. The present study aimed to evaluate the interrater validity and reliability of three different methods: weight of paper template (WPT), paper template area (PTA), and photographic analysis. Sixteen male Wistar rats had their cranially based dorsal skin flap elevated. Read More

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http://dx.doi.org/10.1089/wound.2017.0758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946727PMC

Three-Dimensional Printing and Cell Therapy for Wound Repair.

Adv Wound Care (New Rochelle) 2018 May;7(5):145-155

ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, Wollongong, Australia.

Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach to regenerative medicine, whereby cells and cell-based materials can be dispensed in fine spatial arrangements to mimic native tissue. Read More

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http://dx.doi.org/10.1089/wound.2017.0752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946736PMC
May 2018
2 Reads

Collagen Fibers in the Healing Process of Rat Achilles Tendon Rupture Using Different Times of Ultrasound Therapy.

Adv Wound Care (New Rochelle) 2018 Apr;7(4):114-120

Department of Physical Therapy, Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, Brazil.

The aim of this study was to evaluate the organization of collagen fibers in the healing process of rat Achilles tendon rupture using different times of ultrasound therapy (TUS). Forty Wistar rats were selected. Among these, 32 were submitted to total and divided into 5 groups: control group (CG,  = 8), without tenotomy or any treatment; tenotomy group ( = 8), with tenotomy and without treatment; TUS groups-TUS3 ( = 8), TUS4 ( = 8), and TUS5 ( = 8)-submitted to tenotomy and treated with TUS for 3, 4, and 5 min per effective radiating area (ERA), respectively. Read More

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http://dx.doi.org/10.1089/wound.2017.0748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915266PMC
April 2018
6 Reads

Assessing the Healing of Venous Leg Ulcers Using a Noncontact Near-Infrared Optical Imaging Approach.

Adv Wound Care (New Rochelle) 2018 Apr;7(4):134-143

Department of Biomedical Engineering, Optical Imaging Laboratory, Florida International University, Miami, Florida.

Venous leg ulcers (VLUs) are one of the most common complications in lower extremity wounds. To date, clinicians employ visual inspection of the wound site during its healing process by monitoring surface granulation and reduction in wound size across weeks of treatment. In this study, a handheld near-infrared optical scanner (NIROS) has been developed at the Optical Imaging Laboratory to differentiate healing from nonhealing VLUs based on differences in blood flow to the wound and its surroundings. Read More

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http://dx.doi.org/10.1089/wound.2017.0745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905867PMC
April 2018
6 Reads

Highly Diluted Acetylcholine Promotes Wound Repair in an Model.

Adv Wound Care (New Rochelle) 2018 Apr;7(4):121-133

Physiology Laboratory, Department of Translational Medicine, UPO, Novara, Italy.

Wound healing is a dynamic, interactive, and complex process that involves a series of events, including inflammation, migration, proliferation, granulation tissue formation, and matrix remodeling. Despite the high frequency of serious slow-healing wounds, there is still no adequate therapy. The aim of this study is to evaluate a new highly diluted acetylcholine (Ach) formulation obtained through a sequential kinetic activation (SKA) method applied to a wound healing model to verify the hypothesis that a low dose of Ach could be a more physiological stimulus for healing, by stimulating muscarinic and nicotinic receptors and their related intracellular pathways. Read More

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http://dx.doi.org/10.1089/wound.2017.0766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905879PMC
April 2018
2 Reads

Bacterial Aggregates Establish at the Edges of Acute Epidermal Wounds.

Adv Wound Care (New Rochelle) 2018 Apr;7(4):105-113

Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

The bacterial composition and distribution were evaluated in acute standardized epidermal wounds and uninjured skin by a molecular technology benchmarked to conventional culturing. This was done to reveal whether bacterial biofilm is present in acute wounds. On the buttock of 26 healthy volunteers, 28 suction blisters were made and de-roofed. Read More

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http://dx.doi.org/10.1089/wound.2017.0770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905854PMC
April 2018
4 Reads

Xanthine Oxidoreductase: A Novel Therapeutic Target for the Treatment of Chronic Wounds?

Adv Wound Care (New Rochelle) 2018 Mar;7(3):95-104

Institute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore.

Chronic wounds are a major burden to patients and to healthcare systems worldwide. These wounds are difficult to heal and treatment is often lengthy and expensive. This has led to research efforts focussed on the wound environment attempting to understand the underlying pathological mechanisms of impaired wound healing. Read More

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http://dx.doi.org/10.1089/wound.2016.0724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833883PMC
March 2018
9 Reads
5.200 Impact Factor

Publicly Reported Wound Healing Rates: The Fantasy and the Reality.

Adv Wound Care (New Rochelle) 2018 Mar;7(3):77-94

Strategic Solutions, Inc., Cody, Wyoming.

We compare real-world data from the U.S. Wound Registry (USWR) with randomized controlled trials and publicly reported wound outcomes and develop criteria for honest reporting of wound outcomes, a requirement of the new Quality Payment Program (QPP). Read More

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http://dx.doi.org/10.1089/wound.2017.0743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833884PMC
March 2018
2 Reads

Comparative Effectiveness of a Bioengineered Living Cellular Construct and Cryopreserved Cadaveric Skin Allograft for the Treatment of Venous Leg Ulcers in a Real-World Setting.

Adv Wound Care (New Rochelle) 2018 Mar;7(3):69-76

Organogenesis, Inc., Canton, Massachusetts.

A variety of advanced biological therapies are available for the treatment of chronic wounds such as venous leg ulcers (VLUs), but real-world comparative effectiveness data that can help guide decisions around treatments are currently lacking. This analysis was designed to compare the effectiveness of a bioengineered living cellular construct (BLCC) to a cryopreserved cadaveric skin allograft (CCSA) for the treatment of VLUs. Treatment records were collected from a large wound care-specific electronic medical record database on 717 patients (799 VLUs) receiving treatment at 177 wound care centers. Read More

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http://dx.doi.org/10.1089/wound.2017.0738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833885PMC

Review of the Current Management of Pressure Ulcers.

Adv Wound Care (New Rochelle) 2018 Feb;7(2):57-67

Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, California.

The incidence of pressure ulcers is increasing due to our aging population and the increase in the elderly living with disability. Learning how to manage pressure ulcers appropriately is increasingly important for all professionals in wound care. Many new dressings and treatment modalities have been developed over the recent years and the goal of this review is to highlight their benefits and drawbacks to help providers choose their tools appropriately. Read More

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http://dx.doi.org/10.1089/wound.2016.0697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792240PMC
February 2018
4 Reads

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation.

Adv Wound Care (New Rochelle) 2018 Feb;7(2):47-56

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California.

Excessive scarring is major clinical and financial burden in the United States. Improved therapies are necessary to reduce scarring, especially in patients affected by hypertrophic and keloid scars. Advances in our understanding of mechanical forces in the wound environment enable us to target mechanical forces to minimize scar formation. Read More

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http://dx.doi.org/10.1089/wound.2016.0709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792236PMC
February 2018
20 Reads

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions.

Adv Wound Care (New Rochelle) 2018 Feb;7(2):29-45

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California.

Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological problems. Scarring in humans is the end result of the wound healing process, which has evolved to rapidly repair injuries. Read More

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http://dx.doi.org/10.1089/wound.2016.0696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792238PMC
February 2018
7 Reads

Noncoding RNAs in Wound Healing: A New and Vast Frontier.

Adv Wound Care (New Rochelle) 2018 Jan;7(1):19-27

Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California.

Wound healing requires a highly orchestrated coordination of processes that are not yet fully understood. Therefore, available clinical therapies are thus far limited in their efficacy in preventing and treating both chronic wounds and scars. Current gene-based therapeutics is largely based on our understanding of the protein-coding genome and proteins involved in known wound healing pathways. Read More

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http://www.liebertpub.com/doi/10.1089/wound.2017.0765
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http://dx.doi.org/10.1089/wound.2017.0765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770091PMC
January 2018
12 Reads

An Improved Humanized Mouse Model for Excisional Wound Healing Using Double Transgenic Mice.

Adv Wound Care (New Rochelle) 2018 Jan;7(1):11-17

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California.

Splinting full-thickness cutaneous wounds in mice has allowed for a humanized model of wound healing. Delineating the epithelial edge and assessing time to closure of these healing wounds via macroscopic visualization have remained a challenge. Double transgenic mice were created by crossbreeding K14-Cre and ROSA reporter mice. Read More

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http://dx.doi.org/10.1089/wound.2017.0772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770115PMC
January 2018
21 Reads

Pathway Analysis of Gene Expression of E14 Versus E18 Fetal Fibroblasts.

Adv Wound Care (New Rochelle) 2018 Jan;7(1):1-10

Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California.

Fetuses early in gestation heal skin wounds without forming scars. The biological mechanisms behind this process are largely unknown. Fibroblasts, however, are cells known to be intimately involved in wound healing and scar formation. Read More

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http://dx.doi.org/10.1089/wound.2017.0763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770085PMC
January 2018
15 Reads

Incisional Negative-Pressure Wound Therapy for Perineal Wounds After Abdominoperineal Resection for Rectal Cancer, a Pilot Study.

Adv Wound Care (New Rochelle) 2017 Dec;6(12):425-429

Department of Surgery, IJsselland Hospital, Capelle aan de IJssel, The Netherlands.

Abdominoperineal resection (APR) is associated with high incidence of surgical wound infections. The use of incisional negative-pressure wound therapy (iNPWT) is known to reduce wound infections for several surgical indications. The aim of this pilot study was to investigate the potential of a new portable negative-pressure therapy device on perineal wound healing in patients undergoing APR. Read More

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http://dx.doi.org/10.1089/wound.2017.0749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734143PMC
December 2017
3 Reads

A Low-Cost Technique for Intraoperative Imaging of Cell Delivery and Retention in a Model of Delayed Wound Healing.

Adv Wound Care (New Rochelle) 2017 Dec;6(12):413-424

Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa.

Techniques to validate successful delivery of cell products are expensive, time-consuming, and require transport of the animal to imaging facilities, preventing their widespread use as documentation tools. The goal of this study was to determine if a low-cost portable microscope could provide sufficient performance to be used to document delivery of cell products and track retention over time. A Dino-Lite fluorescence microscope and an Odyssey CLx whole-animal scanner were compared on the basis of resolution, sensitivity, and linearity. Read More

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http://dx.doi.org/10.1089/wound.2017.0751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734161PMC
December 2017
1 Read

A Comparison of the Effects of Topical Prolavacid Solution (a Polyhexamethylene Biguanide-Based Wound Cleanser) and Medihoney Ointment in a Rat Model of Cutaneous Wound.

Adv Wound Care (New Rochelle) 2017 Dec;6(12):407-412

Department of Orthopaedics, Sahlgrenska Hospital, Göteborg University, Gothenburg, Sweden.

This experimental work examined the healing effect and probable adverse impact of topical Prolavacid solution (a polyhexamethylene biguanide-based wound cleanser) and topical Medihoney ointment in an animal model of cutaneous wound. We randomly divided 22 adult Sprague-Dawley rats (all were male) in two groups ( = 11): (1) those for which Prolavacid solution was poured on the skin wound surface; and (2) those animals for which Medihoney ointment was applied to the wounds. These two agents were applied daily throughout the study period (21 days). Read More

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http://www.liebertpub.com/doi/10.1089/wound.2017.0747
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http://dx.doi.org/10.1089/wound.2017.0747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734149PMC
December 2017
16 Reads

Wound-Healing Potential of Oil of in Excision Wounds of Male Sprague Dawley Rats.

Adv Wound Care (New Rochelle) 2017 Dec;6(12):401-406

Department of Stem-Cell and Tissue Engineering, Tbilisi State Medical University, Tbilisi, Georgia.

To evaluate the wound-healing activity of oil of in excision wounds of male white rats. The current methods of wound management involve the use of antibiotic creams. The search for more natural materials for the purpose of healing of wounds has led to the discoveries of potential agents prepared from plant extracts. Read More

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http://dx.doi.org/10.1089/wound.2017.0746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734146PMC
December 2017
1 Read