150 results match your criteria Advances in virology[Journal]


Peste Des Petits Ruminants (PPR) in Dromedary Camels and Small Ruminants in Mandera and Wajir Counties of Kenya.

Adv Virol 2019 4;2019:4028720. Epub 2019 Mar 4.

Department of Veterinary Pathology, Microbiology and Parasitology, University of Nairobi, P.O. Box 29053, Kangemi, Kenya.

A study was conducted to determine the presence of Peste des petits ruminants (PPR) in camel population kept together with small ruminants in Isiolo, Mandera, Marsabit, and Wajir counties of Kenya. This was done in the wake of a disease with unknown etiology "" camels in the horn of Africa. Thirty-eight (38) samples, 12, 8, 15, and 3 samples, were collected from Mandera, Wajir, Isiolo, and Marsabit, respectively, from 25 camels, 7 goats, and 4 sheep. Read More

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http://dx.doi.org/10.1155/2019/4028720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425320PMC

Genetic Diversity and Phylogenetic Analysis of Isolates from Turkey.

Adv Virol 2019 1;2019:7163747. Epub 2019 Jan 1.

Applied Sciences University of Isparta, Faculty of Agricultural Sciences and Technologies, Department of Plant Protection, 32260 Isparta, Turkey.

The presence of (CTV) in Turkey has been known since the 1960s and the virus was detected in all citrus growing regions of the country. Even though serological and biological characteristics of CTV have been studied since the 1980s, molecular characteristics of CTV isolates have not been studied to date in Turkey. In this study, molecular characteristics of 15 CTV isolates collected from different citrus growing regions of Turkey were determined by amplification, cloning, and sequencing of their major coat protein (CP) genes. Read More

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http://dx.doi.org/10.1155/2019/7163747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393893PMC
January 2019
1 Read

Apoptotic and Early Innate Immune Responses to PB1-F2 Protein of Influenza A Viruses Belonging to Different Subtypes in Human Lung Epithelial A549 Cells.

Adv Virol 2018 31;2018:5057184. Epub 2018 Dec 31.

Microbial Containment Complex, National Institute of Virology, Sus Road, Pashan, Pune 411021, India.

PB1-F2 is a multifunctional protein and contributes to the pathogenicity of influenza A viruses. PB1-F2 is known to have strain and cell specific functions. In this study we have investigated the apoptotic and inflammatory responses of PB1-F2 protein from influenza viruses of diverse pathogenicities in A549 lung epithelial cells. Read More

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https://www.hindawi.com/journals/av/2018/5057184/
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http://dx.doi.org/10.1155/2018/5057184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330835PMC
December 2018
11 Reads

Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook.

Adv Virol 2018 2;2018:6097291. Epub 2018 Dec 2.

Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Newcastle disease (ND) is one of the most important avian diseases with considerable threat to the productivity of poultry all over the world. The disease is associated with severe respiratory, gastrointestinal, and neurological lesions in chicken leading to high mortality and several other production related losses. The aetiology of the disease is an avian paramyxovirus type-1 or Newcastle disease virus (NDV), whose isolates are serologically grouped into a single serotype but genetically classified into a total of 19 genotypes, owing to the continuous emergence and evolution of the virus. Read More

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https://www.hindawi.com/journals/av/2018/6097291/
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http://dx.doi.org/10.1155/2018/6097291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304561PMC
December 2018
11 Reads

Quasispecies Changes with Distinctive Point Mutations in the Hepatitis C Virus Internal Ribosome Entry Site (IRES) Derived from PBMCs and Plasma.

Adv Virol 2018 19;2018:4835252. Epub 2018 Nov 19.

University of Nicosia Medical School, Nicosia, Cyprus.

The 5' untranslated region (UTR) of the hepatitis C virus (HCV) genome contains the internal ribosome entry site (IRES), a highly conserved RNA structure essential for cap-independent translation of the viral polyprotein. HCV, apart from the liver, is thought to be associated with lymphocyte subpopulations of peripheral blood mononuclear cells (PBMCs), in lymph nodes and brain tissue. In this study, RT-PCR, cloning, and sequence analysis were employed to investigate the quasispecies nature of the 5'UTR following extraction of viral RNA from PBMCs and plasma of HCV infected individuals. Read More

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http://dx.doi.org/10.1155/2018/4835252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276526PMC
November 2018
1 Read

Prevalence of Human Sapovirus in Low and Middle Income Countries.

Adv Virol 2018 2;2018:5986549. Epub 2018 Sep 2.

Department of Microbiology, School of Mathematical and Natural Sciences, University of Venda, South Africa.

Background: Sapovirus (SV) infection is a public health concern which plays an important role in the burden of diarrhoeal diseases, causing acute gastroenteritis in people of all ages in both outbreaks and sporadic cases worldwide.

Objective/study Design: The purpose of this report is to summarise the available data on the detection of human SV in low and middle income countries. A systematic search on PubMed and ScienceDirect database for SV studies published between 2004 and 2017 in low and middle income countries was done. Read More

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http://dx.doi.org/10.1155/2018/5986549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139206PMC
September 2018

The Study of Viral RNA Diversity in Bird Samples Using De Novo Designed Multiplex Genus-Specific Primer Panels.

Adv Virol 2018 12;2018:3248285. Epub 2018 Aug 12.

Central Research Institute of Epidemiology, Moscow 111123, Russia.

Advances in the next generation sequencing (NGS) technologies have significantly increased our ability to detect new viral pathogens and systematically determine the spectrum of viruses prevalent in various biological samples. In addition, this approach has also helped in establishing the associations of viromes with many diseases. However, unlike the metagenomic studies using rRNA for the detection of bacteria, it is impossible to create universal oligonucleotides to target all known and novel viruses, owing to their genomic diversity and variability. Read More

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https://www.hindawi.com/journals/av/2018/3248285/
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http://dx.doi.org/10.1155/2018/3248285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109506PMC
August 2018
21 Reads

: Several Features, Properties, and Application.

Adv Virol 2018 19;2018:1973705. Epub 2018 Jun 19.

Department of Virology, Lomonosov Moscow State University, Moscow 119234, Russia.

(AltMV) is a typical member of the genus in its morphology and genome structure; still it exhibits a number of unique features. They allow this virus to be considered a promising object for biotechnology. Virions and virus-like particles (VLPs) of AltMV are stable in a wide range of conditions, including sera of laboratory animals. Read More

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http://dx.doi.org/10.1155/2018/1973705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029478PMC

Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients.

Adv Virol 2018 12;2018:7863412. Epub 2018 Mar 12.

Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.

Background: Extracellular vesicles (EVs) are membrane bound, secreted by cells, and detected in bodily fluids, including urine, and contain proteins, RNA, and DNA. Our goal was to identify HIV and human proteins (HPs) in urinary EVs from HIV+ patients and compare them to HIV- samples.

Methods: Urine samples were collected from HIV+ ( = 35) and HIV- ( = 12) individuals. Read More

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http://dx.doi.org/10.1155/2018/7863412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867598PMC
March 2018
4 Reads

Questioning the Extreme Neurovirulence of Monkey B Virus .

Adv Virol 2018 13;2018:5248420. Epub 2018 Feb 13.

Department of Anthropology and Center for Studies in Ecology and Demography, University of Washington, Seattle, WA 98195, USA.

Monkey B virus ( 1; BV) occurs naturally in macaques of the genus which includes rhesus and long-tailed (cynomolgus) monkeys that are widely used in biomedical research. BV is closely related to the human herpes simplex viruses (HSV), and BV infections in its natural macaque host are quite similar to HSV infections in humans. Zoonotic BV is extremely rare, having been diagnosed in only a handful of North American facilities with the last documented case occurring in 1998. Read More

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http://dx.doi.org/10.1155/2018/5248420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831965PMC
February 2018
3 Reads

Adaptation and Molecular Characterization of Two Malaysian Very Virulent Infectious Bursal Disease Virus Isolates Adapted in BGM-70 Cell Line.

Adv Virol 2017 5;2017:8359047. Epub 2017 Nov 5.

Laboratory of Vaccine and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.

Two Malaysian very virulent infectious bursal disease virus (vvIBDV) strains UPM0081 and UPM190 (also known as UPMB00/81 and UPM04/190, respectively) isolated from local IBD outbreaks were serially passaged 12 times (EP12) in specific pathogen free (SPF) chicken embryonated eggs (CEE) by chorioallantoic membrane (CAM) route. The EP12 isolate was further adapted and serially propagated in BGM-70 cell line up to 20 passages (P20). Characteristic cytopathic effects (CPEs) were subtly observed at P1 in both isolates 72 hours postinoculation (pi). Read More

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http://dx.doi.org/10.1155/2017/8359047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694579PMC
November 2017
8 Reads

Phage-Displayed Peptides Selected to Bind Envelope Glycoprotein Show Antiviral Activity against Dengue Virus Serotype 2.

Adv Virol 2017 10;2017:1827341. Epub 2017 Sep 10.

Center of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Building 219, Ciudad del Saber, Apartado 0843-01103, Panamá, Panama.

Dengue virus is a growing public health threat that affects hundreds of million peoples every year and leave huge economic and social damage. The virus is transmitted by mosquitoes and the incidence of the disease is increasing, among other causes, due to the geographical expansion of the vector's range and the lack of effectiveness in public health interventions in most prevalent countries. So far, no highly effective vaccine or antiviral has been developed for this virus. Read More

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http://dx.doi.org/10.1155/2017/1827341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610824PMC
September 2017
7 Reads

Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates.

Adv Virol 2017 29;2017:1324276. Epub 2017 Aug 29.

Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong.

This study evaluated a new multiplex kit, Luminex NxTAG Respiratory Pathogen Panel, for respiratory pathogens and compared it with xTAG RVP Fast v2 and FilmArray Respiratory Panel using nasopharyngeal aspirate specimens and culture isolates of different swine/avian-origin influenza A subtypes (H2N2, H5N1, H7N9, H5N6, and H9N2). NxTAG RPP gave sensitivity of 95.2%, specificity of 99. Read More

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http://dx.doi.org/10.1155/2017/1324276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602486PMC
August 2017
7 Reads

Global Status of Type 2 and Its Associated Diseases in Sub-Saharan Africa.

Adv Virol 2017 12;2017:6807964. Epub 2017 Mar 12.

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Private Bag X1314, Alice 5700, Eastern Cape, South Africa; Applied and Environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice 5700, Eastern Cape, South Africa; Academic and Research Division, University of Fort Hare, Private Bag X1314, Alice, Eastern Cape, South Africa.

Globally, type 2 (PCV2) is a recognized viral pathogen of great economic value in pig farming. It is the major cause of ravaging postweaning multisystemic wasting syndrome (PMWS) and many other disease syndromes generally regarded as associated diseases (PCVAD) in Europe. PCV2 infections, specifically PMWS, had impacted huge economic loss on swine production at different regions of the world. Read More

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http://dx.doi.org/10.1155/2017/6807964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366187PMC
March 2017
5 Reads

Patterns of Human Respiratory Viruses and Lack of MERS-Coronavirus in Patients with Acute Upper Respiratory Tract Infections in Southwestern Province of Saudi Arabia.

Adv Virol 2017 27;2017:4247853. Epub 2017 Feb 27.

Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

We undertook enhanced surveillance of those presenting with respiratory symptoms at five healthcare centers by testing all symptomatic outpatients between November 2013 and January 2014 (winter time). Nasal swabs were collected from 182 patients and screened for MERS-CoV as well as other respiratory viruses using RT-PCR and multiplex microarray. A total of 75 (41. Read More

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http://dx.doi.org/10.1155/2017/4247853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350310PMC
February 2017
14 Reads

Herpes Simplex Virus Latency: The DNA Repair-Centered Pathway.

Authors:
Jay C Brown

Adv Virol 2017 1;2017:7028194. Epub 2017 Feb 1.

Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA.

Like all herpesviruses, herpes simplex virus 1 (HSV1) is able to produce lytic or latent infections depending on the host cell type. Lytic infections occur in a broad range of cells while latency is highly specific for neurons. Although latency suggests itself as an attractive target for novel anti-HSV1 therapies, progress in their development has been slowed due in part to a lack of agreement about the basic biochemical mechanisms involved. Read More

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http://dx.doi.org/10.1155/2017/7028194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309397PMC
February 2017

Incidence and Molecular Characterization of Hepatitis E Virus from Swine in Eastern Cape, South Africa.

Adv Virol 2017 16;2017:1073253. Epub 2017 Jan 16.

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Private Bag X1314, Alice, Eastern Cape Province 5700, South Africa; Applied and Environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice, Eastern Cape Province 5700, South Africa.

Hepatitis E virus-mediated infection is a serious public health concern in economically developing nations of the world. Globally, four major genotypes of HEV have been documented. Hepatitis E has been suggested to be zoonotic owing to the increase of evidence through various studies. Read More

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http://dx.doi.org/10.1155/2017/1073253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278201PMC
January 2017
7 Reads

Molecular Detection of Torque Teno Sus Virus and Coinfection with African Swine Fever Virus in Blood Samples of Pigs from Some Slaughterhouses in Nigeria.

Adv Virol 2016 19;2016:6341015. Epub 2016 Oct 19.

Department of Biomolecular Resources and Biolab Sciences, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda.

Torque teno sus virus 1 (TTSuV1a/TTSuV1b) infection is present in pig herds worldwide. This study investigated the prevalence of TTSuV1a/TTSuV1b infections in domestic pigs from some slaughterhouses in Nigeria as well as coinfection with African swine fever virus (ASFV) and described the phylogeny in relation to global strains. One hundred and eighty-one (181) blood samples from four slaughterhouses were used for the study and viral nucleic acid detection was carried out by PCR. Read More

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http://dx.doi.org/10.1155/2016/6341015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090082PMC
October 2016
1 Read

Immunogenicity of RSV F DNA Vaccine in BALB/c Mice.

Adv Virol 2016 5;2016:7971847. Epub 2016 Sep 5.

Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA.

Respiratory syncytial virus (RSV) causes severe acute lower respiratory tract disease leading to numerous hospitalizations and deaths among the infant and elderly populations worldwide. There is no vaccine or a less effective drug available against RSV infections. Natural RSV infection stimulates the Th1 immune response and activates the production of neutralizing antibodies, while earlier vaccine trials that used UV-inactivated RSV exacerbated the disease due to the activation of the allergic Th2 response. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027326PMC
http://dx.doi.org/10.1155/2016/7971847DOI Listing
September 2016
10 Reads

Isolation and Metagenomic Identification of Avian Leukosis Virus Associated with Mortality in Broiler Chicken.

Adv Virol 2016 15;2016:9058403. Epub 2016 Aug 15.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor Darul Ehsan, Malaysia; Laboratory of Vaccine and Immunotherapeutic, Institute of Bioscience, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor Darul Ehsan, Malaysia.

Avian leukosis virus (ALV) belongs to the family Retroviridae and causes considerable economic losses to the poultry industry. Following an outbreak associated with high mortality in a broiler flock in northern part of Malaysia, kidney tissues from affected chickens were submitted for virus isolation and identification in chicken embryonated egg and MDCK cells. Evidence of virus growth was indicated by haemorrhage and embryo mortality in egg culture. Read More

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http://dx.doi.org/10.1155/2016/9058403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002465PMC
September 2016
9 Reads

Molecular and Phylogenetic Analysis of Bovine Papillomavirus Type 1: First Report in Iraqi Cattle.

Adv Virol 2016 20;2016:2143024. Epub 2016 Jun 20.

Iraqi Center for Cancer and Medical Genetic Research, Al-Mustansiriya University, Al-Qadisiyah, Baghdad 1001, Iraq.

This study aimed to provide the first molecular characterization of bovine papillomavirus type 1 (BPV-1) in Iraq. BPV is a widely spread oncogenic virus in Iraqi cattle and is associated with the formation of both benign and malignant lesions, resulting in notable economic losses in dairy and beef cattle. In the current study, 140 cutaneous papilloma specimens were collected from cattle in central Iraq. Read More

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http://dx.doi.org/10.1155/2016/2143024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931078PMC
July 2016
6 Reads
2 Citations

Vitamin D-Regulated MicroRNAs: Are They Protective Factors against Dengue Virus Infection?

Adv Virol 2016 11;2016:1016840. Epub 2016 May 11.

Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia (UdeA), Calle 70 No. 52-51, Medellín, Colombia.

Over the last few years, an increasing body of evidence has highlighted the critical participation of vitamin D in the regulation of proinflammatory responses and protection against many infectious pathogens, including viruses. The activity of vitamin D is associated with microRNAs, which are fine tuners of immune activation pathways and provide novel mechanisms to avoid the damage that arises from excessive inflammatory responses. Severe symptoms of an ongoing dengue virus infection and disease are strongly related to highly altered production of proinflammatory mediators, suggesting impairment in homeostatic mechanisms that control the host's immune response. Read More

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http://www.hindawi.com/journals/av/2016/1016840/
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http://dx.doi.org/10.1155/2016/1016840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879221PMC
June 2016
1 Read

A Cross-Study Biomarker Signature of Human Bronchial Epithelial Cells Infected with Respiratory Syncytial Virus.

Adv Virol 2016 4;2016:3605302. Epub 2016 May 4.

Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil.

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in children, elderly, and immunocompromised individuals. Despite of advances in diagnosis and treatment, biomarkers of RSV infection are still unclear. To understand the host response and propose signatures of RSV infection, previous studies evaluated the transcriptional profile of the human bronchial epithelial cell line-BEAS-2B-infected with different strains of this virus. Read More

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http://dx.doi.org/10.1155/2016/3605302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870338PMC
June 2016
2 Reads

Direct Detection and Identification of Enteroviruses from Faeces of Healthy Nigerian Children Using a Cell-Culture Independent RT-Seminested PCR Assay.

Adv Virol 2016 20;2016:1412838. Epub 2016 Mar 20.

Department of Virology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria; WHO National Polio Laboratory, University of Ibadan, Ibadan, Oyo State, Nigeria.

Recently, a cell-culture independent protocol for detection of enteroviruses from clinical specimen was recommended by the WHO for surveillance alongside the previously established protocols. Here, we investigated whether this new protocol will show the same enterovirus diversity landscape as the established cell-culture dependent protocols. Faecal samples were collected from sixty apparently healthy children in Ibadan, Nigeria. Read More

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http://dx.doi.org/10.1155/2016/1412838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818813PMC
April 2016
2 Reads

Serological Survey of Hantavirus in Inhabitants from Tropical and Subtropical Areas of Brazil.

Adv Virol 2016 10;2016:8628949. Epub 2016 Mar 10.

Laboratório de Virologia Clínica e Molecular, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil.

Brazil has reported more than 1,600 cases of hantavirus cardiopulmonary syndrome (HPS) since 1993, with a 39% rate of reported fatalities. Using a recombinant nucleocapsid protein of Araraquara virus, we performed ELISA to detect IgG antibodies against hantavirus in human sera. The aim of this study was to analyze hantavirus antibody levels in inhabitants from a tropical area (Amazon region) in Rondônia state and a subtropical (Atlantic Rain Forest) region in São Paulo state, Brazil. Read More

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http://dx.doi.org/10.1155/2016/8628949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806265PMC
April 2016
11 Reads

Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia.

Adv Virol 2016 22;2016:7310894. Epub 2016 Feb 22.

Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa.

Infection with HIV is known to increase the risk of cervical cancer. In addition, evidence suggests that concurrent infection with multiple human papillomavirus (HPV) genotypes increases the risk of cervical dysplasia more than infection with a single HPV genotype. However, the impact of the combination of HIV coinfection and presence of multiple concurrent HPV infections on the risk of cervical dysplasia is uncertain. Read More

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http://dx.doi.org/10.1155/2016/7310894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779813PMC
March 2016
7 Reads

Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model.

Adv Virol 2016 18;2016:8059607. Epub 2016 Feb 18.

Institute of Clinical Immunology, Yadrincevskaya Street 14, 630047 Novosibirsk-47, Russia.

Establishment of small animal models of Ebola virus (EBOV) infection is important both for the study of genetic determinants involved in the complex pathology of EBOV disease and for the preliminary screening of antivirals, production of therapeutic heterologic immunoglobulins, and experimental vaccine development. Since the wild-type EBOV is avirulent in rodents, the adaptation series of passages in these animals are required for the virulence/lethality to emerge in these models. Here, we provide an overview of our several adaptation series in guinea pigs, which resulted in the establishment of guinea pig-adapted EBOV (GPA-EBOV) variants different in their characteristics, while uniformly lethal for the infected animals, and compare the virologic, genetic, pathomorphologic, and immunologic findings with those obtained in the adaptation experiments of the other research groups. Read More

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http://dx.doi.org/10.1155/2016/8059607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775767PMC
March 2016
3 Reads

Exosomes in Human Immunodeficiency Virus Type I Pathogenesis: Threat or Opportunity?

Adv Virol 2016 4;2016:9852494. Epub 2016 Jan 4.

Molecular Pathology Unit, Cancer Research Centre (CaRC), Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia.

Nanometre-sized vesicles, also known as exosomes, are derived from endosomes of diverse cell types and present in multiple biological fluids. Depending on their cellular origins, the membrane-bound exosomes packed a variety of functional proteins and RNA species. These microvesicles are secreted into the extracellular space to facilitate intercellular communication. Read More

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http://dx.doi.org/10.1155/2016/9852494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766318PMC
March 2016
42 Reads
10 Citations

Pathogenesis and Diagnostic Approaches of Avian Infectious Bronchitis.

Adv Virol 2016 3;2016:4621659. Epub 2016 Feb 3.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.

Infectious bronchitis (IB) is one of the major economically important poultry diseases distributed worldwide. It is caused by infectious bronchitis virus (IBV) and affects both galliform and nongalliform birds. Its economic impact includes decreased egg production and poor egg quality in layers, stunted growth, poor carcass weight, and mortality in broiler chickens. Read More

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http://dx.doi.org/10.1155/2016/4621659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756178PMC
March 2016
51 Reads
3 Citations

Serological Investigation of Akabane Virus Infection in Cattle and Sheep in Nigeria.

Adv Virol 2016 26;2016:2936082. Epub 2016 Jan 26.

Department of Veterinary Microbiology and Parasitology, University of Ibadan, Ibadan 20005, Nigeria.

Akabane virus (AKAV) is recognized as an important pathogen that causes abortions and congenital malformations in ruminants. However, it has not received adequate attention in Nigeria. Therefore, in investigating this disease, serum samples from 184 (abattoir and farm) head of cattle and 184 intensively reared sheep from two states in southwest Nigeria were screened for antibodies against AKAV using enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.1155/2016/2936082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746297PMC
February 2016
60 Reads
2 Citations

Expression of Factor X in BHK-21 Cells Promotes Low Pathogenic Influenza Viruses Replication.

Adv Virol 2015 31;2015:675921. Epub 2015 Dec 31.

Razi Vaccine & Serum Research Institute, P.O. Box 31975-148, Karaj 31976 19751, Iran.

A cDNA clone for factor 10 (FX) isolated from chicken embryo inserted into the mammalian cell expression vector pCDNA3.1 was transfected into the baby hamster kidney (BHK-21) cell line. The generated BHK-21 cells with inducible expression of FX were used to investigate the efficacy of the serine transmembrane protease to proteolytic activation of influenza virus hemagglutinin (HA) with monobasic cleavage site. Read More

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http://dx.doi.org/10.1155/2015/675921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735987PMC
February 2016
2 Reads

Antiviral Activity of Resveratrol against Human and Animal Viruses.

Adv Virol 2015 29;2015:184241. Epub 2015 Nov 29.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Resveratrol is a potent polyphenolic compound that is being extensively studied in the amelioration of viral infections both in vitro and in vivo. Its antioxidant effect is mainly elicited through inhibition of important gene pathways like the NF-κβ pathway, while its antiviral effects are associated with inhibitions of viral replication, protein synthesis, gene expression, and nucleic acid synthesis. Although the beneficial roles of resveratrol in several viral diseases have been well documented, a few adverse effects have been reported as well. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676993PMC
December 2015
1 Read
13 Citations

Clinical Symptoms of Human Rotavirus Infection Observed in Children in Sokoto, Nigeria.

Adv Virol 2015 25;2015:890957. Epub 2015 Nov 25.

Faculty of Science, Usmanu Danfodiyo University, PMB 2346, Sokoto, Sokoto State, Nigeria.

Rotavirus has been identified among the most important causes of infantile diarrhoea, especially in developing countries. The present study was undertaken to determine the occurrence and clinical symptoms of human rotavirus disease among children presenting with varying degree of diarrhoea in selected urban hospitals in Sokoto metropolis, Nigeria. Diarrhoea samples were collected from 200 diarrheic children younger than 5 years of age and tested using a commercially available DAKO Rotavirus ELISA kit which detects the presence of human group A rotaviruses. Read More

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http://dx.doi.org/10.1155/2015/890957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673323PMC
December 2015
5 Reads

Evaluating Andrographolide as a Potent Inhibitor of NS3-4A Protease and Its Drug-Resistant Mutants Using In Silico Approaches.

Adv Virol 2015 26;2015:972067. Epub 2015 Oct 26.

Department of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka 572 103, India.

Current combination therapy of PEG-INF and ribavirin against the Hepatitis C Virus (HCV) genotype-1 infections is ineffective in maintaining sustained viral response in 50% of the infection cases. New compounds in the form of protease inhibitors can complement the combination therapy. Asunaprevir is new to the drug regiment as the NS3-4A protease inhibitor, but it is susceptible to two mutations, namely, R155K and D168A in the protein. Read More

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http://dx.doi.org/10.1155/2015/972067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637434PMC
November 2015
27 Reads

Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis.

Adv Virol 2015 26;2015:769837. Epub 2015 Oct 26.

CIRI, International Center for Infectiology Research, Université de Lyon, 69007 Lyon, France ; Inserm, U1111, 69007 Lyon, France ; Ecole Normale Supérieure de Lyon, 69007 Lyon, France ; Centre International de Recherche en Infectiologie, Université Lyon 1, 69007 Lyon, France ; CNRS, UMR 5308, Lyon, France.

Subacute Sclerosing Panencephalitis (SSPE), a rare lethal disease of children and young adults due to persistence of measles virus (MeV) in the brain, is caused by wild type (wt) MeV. Why MeV vaccine strains never cause SSPE is completely unknown. Hypothesizing that this phenotypic difference could potentially be represented by a molecular marker, we compared glycoprotein and matrix (M) genes from SSPE cases with those from the Moraten vaccine strain, searching for differential structural motifs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637438PMC
November 2015
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Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis.

Adv Virol 2015 19;2015:537939. Epub 2015 Oct 19.

Department of Microbiology, Medical College Kolkata, 88 College Street, Kolkata, West Bengal, India.

Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes while HSV-1 is responsible for orolabial and facial lesions. In immunocompromised individuals, like HIV patients, impaired immunity leads to more frequent symptomatic and asymptomatic HSV infection. Fifty-two blood samples from HIV patients with clinically diagnosed HSV infection were taken as cases, while 45 blood samples each from HIV-infected (HIV control) and noninfected patients without any herpetic lesion (non-HIV control) were taken as control. Read More

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http://dx.doi.org/10.1155/2015/537939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628955PMC
November 2015
19 Reads
1 Citation

Comparison of β-Propiolactone and Formalin Inactivation on Antigenicity and Immune Response of West Nile Virus.

Adv Virol 2015 27;2015:616898. Epub 2015 Aug 27.

Arbovirology Group, Entomology and Filariasis Division, Regional Medical Research Centre, ICMR, Northeast Region, Post Box No. 105, Dibrugarh, Assam 786001, India.

West Nile Virus (WNV) is a pathogenic arbovirus that belongs to genus Flavivirus under family Flaviviridae. Till now there are no approved vaccines against WNV for human use. In this study, the effect of two alkylating agents, formaldehyde and β-PL, generally used for inactivated vaccine preparation, was assessed on the basis of antigenic and immunogenic potential of the inactivated WNV. Read More

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http://dx.doi.org/10.1155/2015/616898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564586PMC
September 2015
7 Reads

Investigation of Stilbenoids as Potential Therapeutic Agents for Rotavirus Gastroenteritis.

Adv Virol 2015 26;2015:293524. Epub 2015 Aug 26.

Department of Pathobiology, Texas A&M University, College Station, TX 77843, USA ; Department of Biological Sciences & Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR 72401, USA ; Department of Biology, Stephen F. Austin State University, Nacogdoches, TX 75962, USA.

Rotavirus (RV) infections cause severe diarrhea in infants and young children worldwide. Vaccines are available but cost prohibitive for many countries and only reduce severe symptoms. Vaccinated infants continue to shed infectious particles, and studies show decreased efficacy of the RV vaccines in tropical and subtropical countries where they are needed most. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563088PMC
September 2015
7 Reads

Farming of Plant-Based Veterinary Vaccines and Their Applications for Disease Prevention in Animals.

Adv Virol 2015 13;2015:936940. Epub 2015 Aug 13.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Malaysia.

Plants have been studied for the production of pharmaceutical compounds for more than two decades now. Ever since the plant-made poultry vaccine against Newcastle disease virus made a breakthrough and went all the way to obtain regulatory approval, research to use plants for expression and delivery of vaccine proteins for animals was intensified. Indeed, in view of the high production costs of veterinary vaccines, plants represent attractive biofactories and offer many promising advantages in the production of recombinant vaccine proteins. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550766PMC
September 2015
2 Reads

Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic Period.

Adv Virol 2015 7;2015:560679. Epub 2015 May 7.

Valladolid National Influenza Centre, Avenida Ramón y Cajal No. 7, 47005 Valladolid, Spain ; Microbiology and Immunology Service, University Clinic Hospital of Valladolid, Avenida Ramón y Cajal s/n, 47005 Valladolid, Spain.

Viral infections are one of the main causes of acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Emergence of A/H1N1pdm influenza virus in the 2009 pandemic changed the viral etiology of exacerbations that were reported before the pandemic. The aim of this study was to describe the etiology of respiratory viruses in 195 Spanish patients affected by AE-COPD from the pandemic until the 2011-12 influenza epidemic. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439490PMC
June 2015
4 Reads

Mixed viral infections circulating in hospitalized patients with respiratory tract infections in kuwait.

Adv Virol 2015 23;2015:714062. Epub 2015 Apr 23.

Department of Microbiology, Faculty of Medicine, Kuwait University, 24923 Safat, Kuwait.

The aim of this study was to determine the frequency of viral mixed detection in hospitalized patients with respiratory tract infections and to evaluate the correlation between viral mixed detection and clinical severity. Hospitalized patients with respiratory tract infections (RTI) were investigated for 15 respiratory viruses by using sensitive molecular techniques. In total, 850 hospitalized patients aged between 3 days and 80 years were screened from September 2010 to April 2014. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423027PMC
May 2015
2 Reads
4 Citations

Nelfinavir impairs glycosylation of herpes simplex virus 1 envelope proteins and blocks virus maturation.

Adv Virol 2015 29;2015:687162. Epub 2015 Jan 29.

Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

Nelfinavir (NFV) is an HIV-1 aspartyl protease inhibitor that has numerous effects on human cells, which impart attractive antitumor properties. NFV has also been shown to have in vitro inhibitory activity against human herpesviruses (HHVs). Given the apparent absence of an aspartyl protease encoded by HHVs, we investigated the mechanism of action of NFV herpes simplex virus type 1 (HSV-1) in cultured cells. Read More

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http://dx.doi.org/10.1155/2015/687162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325974PMC
February 2015
2 Reads

The Antiviral Effect of High-Molecular Weight Poly-Gamma-Glutamate against Newcastle Disease Virus on Murine Macrophage Cells.

Adv Virol 2014 30;2014:301386. Epub 2014 Dec 30.

College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Republic of Korea.

This study demonstrates the capacity of HM-γ-PGA treatment to significantly protect murine macrophage cells (RAW 264.7 cells) against NDV infection. Such protection can be explained by the induction of antiviral state of HM-γ-PGA in RAW 264. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293867PMC
January 2015
15 Reads
1 Citation

Detection of influenza virus infection using two PCR methods.

Adv Virol 2014 9;2014:274679. Epub 2014 Dec 9.

Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.

Rapid, accurate, and cost-effective methods to identify the cause of respiratory tract infections are needed to maximize clinical benefit. Outpatients with acute respiratory illness were tested for influenza using a singleplex reverse transcriptase polymerase chain reaction (SRT-PCR) method. A multiplex RT-PCR (MRT-PCR) method tested for influenza and 17 other viruses and was compared with SRT-PCR using chi-square tests. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276355PMC
January 2015
2 Reads

Appearance of L90I and N205S Mutations in Effector Domain of NS1 Gene of pdm (09) H1N1 Virus from India during 2009-2013.

Adv Virol 2014 15;2014:861709. Epub 2014 Sep 15.

Division of Microbiology, National Centre for Disease Control, 22 Sham Nath Marg, Delhi 110054, India.

In the present study, full length sequencing of NS gene was done in 91 samples which were obtained from patients over the time period of five years from 2009 to 2013. The sequencing of NS gene was undertaken in order to determine the changes/mutations taking place in the NS gene of A H1N1 pdm (09) since its emergence in 2009. Analysis has shown that the majority of samples belong to New York (G1 type) strain with valine at position 123. Read More

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http://dx.doi.org/10.1155/2014/861709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181907PMC
October 2014
2 Reads

Structural differences observed in arboviruses of the alphavirus and flavivirus genera.

Adv Virol 2014 16;2014:259382. Epub 2014 Sep 16.

U.S. FDA/National Center for Toxicological Research, Department of Health and Human Services, Jefferson, AR 72079, USA.

Arthropod borne viruses have developed a complex life cycle adapted to alternate between insect and vertebrate hosts. These arthropod-borne viruses belong mainly to the families Togaviridae, Flaviviridae, and Bunyaviridae. This group of viruses contains many pathogens that cause febrile, hemorrhagic, and encephalitic disease or arthritic symptoms which can be persistent. Read More

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http://dx.doi.org/10.1155/2014/259382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182009PMC
October 2014
3 Reads

Molecular characterization of chicken anemia virus circulating in chicken flocks in egypt.

Adv Virol 2014 15;2014:797151. Epub 2014 Sep 15.

Animal Health Research Institute, Kafr El Sheikh Provincial Laboratory, Kafr El Sheikh, Egypt.

Introduction. Although many previous studies reported detection of chicken anemia virus (CAV) in Egypt since 1990, genomic characterization of this circulating CAV has not been published. In the present study, four nucleotide sequences of detected CAV were genetically characterized. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180199PMC
October 2014
7 Reads

Influenza virus aerosols in the air and their infectiousness.

Adv Virol 2014 13;2014:859090. Epub 2014 Aug 13.

Department of Virology, Lomonosov Moscow State University, 1/12 Leninskie Gory, Moscow 119234, Russia.

Influenza is one of the most contagious and rapidly spreading infectious diseases and an important global cause of hospital admissions and mortality. There are some amounts of the virus in the air constantly. These amounts is generally not enough to cause disease in people, due to infection prevention by healthy immune systems. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147198PMC
September 2014
2 Reads

Novel Gyroviruses, including Chicken Anaemia Virus, in Clinical and Chicken Samples from South Africa.

Authors:
Heidi E M Smuts

Adv Virol 2014 29;2014:321284. Epub 2014 Apr 29.

Division Medical Virology/National Health Laboratory Service, Department of Clinical Sciences, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.

Introduction. Chicken anaemia virus, CAV, was until recently the only member of the Gyrovirus genus. 6 novel gyroviruses, AGV2, HGyV1, and GyV3-6, have since been discovered in human and chicken samples. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022007PMC

Screening of viral pathogens from pediatric ileal tissue samples after vaccination.

Adv Virol 2014 23;2014:720585. Epub 2014 Mar 23.

Physical & Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

In 2010, researchers reported that the two US-licensed rotavirus vaccines contained DNA or DNA fragments from porcine circovirus (PCV). Although PCV, a common virus among pigs, is not thought to cause illness in humans, these findings raised several safety concerns. In this study, we sought to determine whether viruses, including PCV, could be detected in ileal tissue samples of children vaccinated with one of the two rotavirus vaccines. Read More

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http://dx.doi.org/10.1155/2014/720585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980782PMC
April 2014
2 Reads