280 results match your criteria Advances in radiation oncology[Journal]


Increases in Serial Pretreatment F-FDG PET-CT Metrics Predict Survival in Early Stage Non-Small Cell Lung Cancer Treated With Stereotactic Ablative Radiation Therapy.

Adv Radiat Oncol 2019 Apr-Jun;4(2):429-437. Epub 2018 Nov 26.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.

Purpose: Quantitative changes in positron emission tomography with computed tomography imaging metrics over serial scans may be predictive biomarkers. We evaluated the relationship of pretreatment metabolic tumor growth rate (MTGR) and standardized uptake value velocity (SUVV) with disease recurrence or death in patients with early-stage non-small cell lung cancer treated with stereotactic ablative radiation therapy (SABR).

Methods And Materials: Under institutional review board approval, we retrospectively identified patients who underwent positron emission tomography with computed tomography at diagnosis and staging and simulation for SABR. Read More

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http://dx.doi.org/10.1016/j.adro.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460103PMC
November 2018

Long-term Clinical Outcomes and Safety Profile of SBRT for Centrally Located NSCLC.

Adv Radiat Oncol 2019 Apr-Jun;4(2):422-428. Epub 2019 Jan 24.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: Previous studies suggest that stereotactic body radiation therapy (SBRT) is associated with higher toxicity rates for central lung tumors relative to peripheral tumors when using 3 fraction SBRT. The initial results from Radiation Therapy Oncology Group study 0813 suggest a safe toxicity profile of SBRT administered in 5 fractions for central non-small cell lung cancer (NSCLC). We reviewed our institutional data to evaluate the safety and efficacy of SBRT for central NSCLC. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460233PMC
January 2019

MRI Radiomic Features Are Independently Associated With Overall Survival in Soft Tissue Sarcoma.

Adv Radiat Oncol 2019 Apr-Jun;4(2):413-421. Epub 2019 Feb 23.

Department of Radiation Oncology, University of Washington, Seattle, Washington.

Purpose: Soft tissue sarcomas (STS) represent a heterogeneous group of diseases, and selection of individualized treatments remains a challenge. The goal of this study was to determine whether radiomic features extracted from magnetic resonance (MR) images are independently associated with overall survival (OS) in STS.

Methods And Materials: This study analyzed 2 independent cohorts of adult patients with stage II-III STS treated at center 1 (N = 165) and center 2 (N = 61). Read More

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http://dx.doi.org/10.1016/j.adro.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460235PMC
February 2019

Machine Learning Methods Uncover Radiomorphologic Dose Patterns in Salivary Glands that Predict Xerostomia in Patients with Head and Neck Cancer.

Adv Radiat Oncol 2019 Apr-Jun;4(2):401-412. Epub 2018 Nov 29.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland.

Purpose: Patients with head-and-neck cancer (HNC) may experience xerostomia after radiation therapy (RT), which leads to compromised quality of life. The purpose of this study is to explore how the spatial pattern of radiation dose (radiomorphology) in the major salivary glands influences xerostomia in patients with HNC.

Methods And Materials: A data-driven approach using spatially explicit dosimetric predictors, voxel dose (ie, actual radiation dose in voxels in parotid glands [PG] and submandibular glands [SMG]) was used to predict whether patients would develop xerostomia 3 months after RT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24521094183024
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http://dx.doi.org/10.1016/j.adro.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460328PMC
November 2018
1 Read

Improvements in CBCT Image Quality Using a Novel Iterative Reconstruction Algorithm: A Clinical Evaluation.

Adv Radiat Oncol 2019 Apr-Jun;4(2):390-400. Epub 2019 Jan 10.

Department of Radiation Oncology, Josephine Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan.

Purpose: This study aimed to evaluate the clinical utility of a novel iterative cone beam computed tomography (CBCT) reconstruction algorithm for prostate and head and neck (HN) cancer.

Methods And Materials: A total of 10 patients with HN and 10 patients with prostate cancer were analyzed. For each patient, raw CBCT acquisition data were used to reconstruct images with a currently available algorithm (FDK_CBCT) and novel iterative algorithm (Iterative_CBCT). Read More

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http://dx.doi.org/10.1016/j.adro.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460237PMC
January 2019

Enhancement of Long-Term External-Internal Correlation by Phase-Shift Detection and Correction Based on Concurrent External Bellows and Internal Navigator Signals.

Adv Radiat Oncol 2019 Apr-Jun;4(2):377-389. Epub 2019 Mar 1.

Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York.

Purpose: The purpose of this study was to enhance the correlation between external and internal respiratory motions by dynamically determining and correcting the patient-specific phase shift between external and internal respiratory waveforms acquired concurrently during respiratory-correlated 4-dimensional magnetic resonance imaging scans.

Methods And Materials: Internal-navigator and external-bellows waveforms were acquired simultaneously during 6- to 15-minute respiratory-correlated 4-dimensional magnetic resonance imaging scans in 10 healthy participants under an institutional review board-approved protocol. The navigator was placed at the right lung-diaphragm interface, and the bellows were placed ∼5 cm inferior to the sternum. Read More

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http://dx.doi.org/10.1016/j.adro.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460238PMC

Quantitative temporal diffusion spectroscopy as an early imaging biomarker of radiation therapeutic response in gliomas: A preclinical proof of concept.

Adv Radiat Oncol 2019 Apr-Jun;4(2):367-376. Epub 2018 Nov 20.

Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee.

Purpose: This study aims to test the ability of quantitative temporal diffusion spectroscopy (qTDS) to assess cellular changes associated with radiation-induced cell death in a rat glioma model.

Methods And Materials: Tumor response to a single fraction of 20 Gy of x-ray radiation was investigated in a rat glioma (9L) model. Tumor response was monitored longitudinally at postinoculation days 21, 23, and 25, using a specific implementation of qTDS with acronym IMPULSED (Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion), as well as conventional diffusion and high-resolution anatomic imaging. Read More

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http://dx.doi.org/10.1016/j.adro.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460331PMC
November 2018

Safety and Feasibility of Magnetic Resonance Imaging Simulation for Radiation Treatment Planning in Pediatric Patients: A Single Institution Experience.

Adv Radiat Oncol 2019 Apr-Jun;4(2):362-366. Epub 2018 Dec 21.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: This study aimed to report on the safety, feasibility, and workflow of using magnetic resonance imaging (MRI) simulation, while immobilized in the treatment position, for radiation therapy treatment planning in the pediatric population.

Methods And Materials: Between May and December 2017, 10 pediatric patients completed both MRI and computed tomography imaging simulation in treatment immobilization for radiation therapy planning for central nervous system disease. We report our initial institutional experience and workflow of the use of MRI simulation in immobilization for treatment planning in this population. Read More

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http://dx.doi.org/10.1016/j.adro.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460291PMC
December 2018

The long-lasting relationship of distress on radiation oncology-specific clinical outcomes.

Adv Radiat Oncol 2019 Apr-Jun;4(2):354-361. Epub 2018 Nov 14.

Virginia Commonwealth University Health System, Massey Cancer Center, Department of Radiation Oncology, Richmond, Virginia.

Purpose: The diagnosis and treatment of cancer can have significant mental health ramifications. The National Comprehensive Cancer Network currently recommends using a distress screening tool to screen patients for distress and facilitate referrals to social service resources. Its association with radiation oncology-specific clinical outcomes has remained relatively unexplored. Read More

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http://dx.doi.org/10.1016/j.adro.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460100PMC
November 2018

Reddit and Radiation Therapy: A Descriptive Analysis of Posts and Comments Over 7 Years by Patients and Health Care Professionals.

Adv Radiat Oncol 2019 Apr-Jun;4(2):345-353. Epub 2019 Feb 13.

Department of Radiation Oncology, University of Pittsburgh School of Medicine and UPMC Hillman Cancer Institute, Pittsburgh, Pennsylvania.

Purpose: Reddit is a social media platform that allows health care professionals (HPs) to anonymously interact with patients. We analyzed content about radiation therapy (RT) on Reddit.

Methods And Materials: Reddit. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460228PMC
February 2019

Early Tolerance Outcomes of Stereotactic Hypofractionated Accelerated Radiation Therapy Concomitant with Pelvic Node Irradiation in High-risk Prostate Cancer.

Adv Radiat Oncol 2019 Apr-Jun;4(2):337-344. Epub 2019 Jan 31.

Departments of Radiation Oncology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.

Purpose: This study aimed to evaluate the toxicity of prostate and pelvic lymph node stereotactic body radiation therapy (SBRT) for high-risk prostate cancer.

Methods And Materials: Twenty-three patients with high-risk or lymph node-positive prostate cancer were treated with SBRT that delivered 37.5 to 40 Gy in 5 fractions to the prostate and seminal vesicles, with concomitant treatment of the pelvic nodes to 25 Gy. Read More

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http://dx.doi.org/10.1016/j.adro.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460324PMC
January 2019

Regional Differences in the Treatment of Localized Prostate Cancer: An Analysis of Surgery and Radiation Utilization in the United States.

Adv Radiat Oncol 2019 Apr-Jun;4(2):331-336. Epub 2019 Jan 23.

Department of Radiation Oncology, Weill Cornell Medical College and NewYork-Presbyterian Hospital, New York, New York.

Purpose: Men with localized prostate cancer have various treatment options available in their management. The optimal approach is controversial and can be influenced by multiple factors. This study aimed to investigate the influence of geographic region on the selection of treatment for prostate cancer. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460229PMC
January 2019

Radiation-related Lymphopenia after Pelvic Nodal Irradiation for Prostate Cancer.

Adv Radiat Oncol 2019 Apr-Jun;4(2):323-330. Epub 2019 Jan 25.

Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia.

Purpose: Given the uncertainty with regard to the effectiveness of pelvic nodal irradiation (PNI) for prostate cancer, we aimed to determine whether patients with prostate cancer who are treated with PNI are at a higher risk of developing radiation-related lymphopenia (RRL).

Methods And Materials: The electronic charts of 886 consecutive patients treated with radiation therapy for prostate cancer between 2006 and 2018 at our institution were retrospectively analyzed. Qualifying patients were those with total lymphocyte counts within 1 year before and 3 to 24 months after the start of radiation therapy. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460292PMC
January 2019

Single-fraction Stereotactic Body Radiation Therapy versus Conventionally Fractionated Radiation Therapy for the Treatment of Prostate Cancer Bone Metastases.

Adv Radiat Oncol 2019 Apr-Jun;4(2):314-322. Epub 2019 Feb 19.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: This study aimed to compare outcomes of patients with prostate cancer with bone metastases treated with stereotactic body radiation therapy (SBRT) versus conventionally fractionated radiation therapy (CFRT).

Methods And Materials: An institutional, retrospective review was conducted of patients with prostate cancer receiving radiation therapy to bone metastases. In-field failure (IFF) was the primary outcome of the study, and distant failure (DF) and biochemical failure (BF) were secondary outcomes. Read More

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http://dx.doi.org/10.1016/j.adro.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460234PMC
February 2019

Treatment strategies and clinical outcomes of locally advanced pancreatic cancer patients treated at high-volume facilities and academic centers.

Adv Radiat Oncol 2019 Apr-Jun;4(2):302-313. Epub 2018 Nov 9.

Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

Purpose: Locally advanced pancreatic cancer (LAPC) treatment has varying practice patterns with poor outcomes. We investigated treatment using single-agent chemotherapy and multiagent chemotherapy (MAC) with or without radiation therapy (RT) at high-volume facilities (HVFs) and academic centers (ACs).

Methods And Materials: The National Cancer Database was used to obtain data on 10,139 patients with LAPC. Read More

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http://dx.doi.org/10.1016/j.adro.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460104PMC
November 2018

Initial Results of a Prospective Study of Adjuvant Pancreatic Stereotactic Body Radiation Therapy for Close or Positive Margins.

Adv Radiat Oncol 2019 Apr-Jun;4(2):294-301. Epub 2018 Nov 29.

Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Purpose: Patients with close or positive margins after surgery for pancreatic carcinoma are at a high risk for recurrence. Stereotactic body radiation therapy (SBRT) allows for safe dose escalation with great conformity and short duration of treatment. Herein, we report the initial results of a prospective observational study that evaluated the efficacy and safety of this treatment option. Read More

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http://dx.doi.org/10.1016/j.adro.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460098PMC
November 2018

Outcomes in the radiosurgical management of metastatic spine disease.

Adv Radiat Oncol 2019 Apr-Jun;4(2):283-293. Epub 2018 Nov 9.

Department of Radiation Medicine, Northwell Health Cancer Institute, Lake Success, New York.

Purpose: Stereotactic body radiation therapy (SBRT) is a common treatment option for patients with metastatic tumors of the spine. The optimal treatment-, tumor-, and patient-specific characteristics necessary to achieve durable outcomes remain less well understood given the heterogeneous nature of the patient population this modality typically serves. The objective of this analysis was to better understand the determinants underlying SBRT spine treatment outcomes. Read More

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http://dx.doi.org/10.1016/j.adro.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460302PMC
November 2018

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas.

Adv Radiat Oncol 2019 Apr-Jun;4(2):268-282. Epub 2018 Nov 20.

Department of Radiation Oncology, Centre François Baclesse, Esch-sur-Alzette, Luxembourg.

Purpose: Glioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for immunotherapy. However, GBM tends to be nonimmunogenic and exhibits a microenvironment with few or no effector T cells, a relatively low nonsynonymous somatic mutational load, and a low predicted neoantigen burden. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24521094183023
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http://dx.doi.org/10.1016/j.adro.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460102PMC
November 2018
1 Read

The effect of breast volume on toxicity using hypofractionated regimens for early stage breast cancer for patients.

Adv Radiat Oncol 2019 Apr-Jun;4(2):261-267. Epub 2018 Nov 1.

Department of Radiation Oncology, University of Kansas Cancer Center, Kansas City, Kansas.

Purpose: Hypofractionated radiation therapy (HFRT) remains underused, despite multiple randomized trials showing the equivalence of HFRT to conventional fractionated radiation therapy (CFRT). We sought to retrospectively review the relationship between breast volume and toxicity for HFRT versus CFRT.

Methods And Materials: Data from 114 patients who received a diagnosis of early stage breast cancer and were treated with lumpectomy and whole breast radiation alone were reviewed. Read More

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http://dx.doi.org/10.1016/j.adro.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460101PMC
November 2018

A Single-Institution Experience in the Preoperative Selection of DCIS Patients for IORT using the ASTRO Consensus Guidelines.

Adv Radiat Oncol 2019 Apr-Jun;4(2):253-260. Epub 2018 Nov 20.

Department of Radiation Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York, New York.

Purpose: Intraoperative radiation therapy (IORT) as a form of accelerated partial breast irradiation (APBI) is controversial given the limited evidence to support its efficacy. However, it remains an attractive option for low-risk patients with ductal carcinoma in situ (DCIS), who derive a small absolute benefit in local control with standard whole breast irradiation (WBI). We examine how the American Society for Therapeutic Radiation Oncology (ASTRO) APBI consensus guidelines (CG) may be applied to the preoperative selection of patients with DCIS for IORT and determine treatment outcomes by CG group. Read More

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http://dx.doi.org/10.1016/j.adro.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460097PMC
November 2018

Nationwide Trends in Heart-Sparing Techniques Utilized in Radiation Therapy for Breast Cancer.

Adv Radiat Oncol 2019 Apr-Jun;4(2):246-252. Epub 2019 Jan 30.

Medical College of Wisconsin, Department of Radiation Oncology, Milwaukee, Wisconsin.

Purpose: Radiation dose to the heart correlates with cardiac-related deaths and may partially diminish the benefit of radiation for breast cancer. This study assessed the current nationwide trends in heart-sparing techniques for breast cancer radiation.

Methods And Materials: In November 2017, an institutional review board-approved survey was sent to radiation oncologists in the United States. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24521094193000
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http://dx.doi.org/10.1016/j.adro.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460327PMC
January 2019
5 Reads

Amelioration of Radiation Enteropathy by Dietary Supplementation With Reduced Coenzyme Q10.

Adv Radiat Oncol 2019 Apr-Jun;4(2):237-245. Epub 2019 Jan 31.

Division of Radiation Oncology, Kobe University Graduate School of Medicine, Hyogo, Japan.

Purpose: Effective methods to ameliorate radiation enteropathy have not been developed. To address this issue, we investigated the reduced form of coenzyme Q10 (rCoQ10) as a potential radioprotector in a mouse model.

Methods And Materials: rCoQ10 was added to a standard laboratory mouse diet at a final concentration of 1. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460318PMC
January 2019
1 Read

First Reported Case of Pediatric Radiation Treatment With Magnetic Resonance Image Guided Radiation Therapy.

Adv Radiat Oncol 2019 Apr-Jun;4(2):233-236. Epub 2019 Jan 31.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1016/j.adro.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460231PMC
January 2019

Recurrent Radiation Recall Mucosal Toxicity of the Upper Aerodigestive Tract: A Case Report.

Adv Radiat Oncol 2019 Apr-Jun;4(2):229-232. Epub 2018 Nov 14.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.adro.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460096PMC
November 2018

Increasing Diversity in Radiation Oncology: A Call to Action.

Adv Radiat Oncol 2019 Apr-Jun;4(2):226-228. Epub 2018 Dec 6.

Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.adro.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460320PMC
December 2018

#WomenWhoCurie: Leveraging Social Media to Promote Women in Radiation Oncology.

Adv Radiat Oncol 2019 Apr-Jun;4(2):218-225. Epub 2019 Jan 29.

University of Michigan, Ann Arbor, Michigan.

The proportion of female trainees in radiation oncology has generally declined despite increasing numbers of female medical students; as a result, radiation oncology is among the bottom 5 specialties in terms of the percentage of female applicants. Recently, social media has been harnessed as a tool to bring recognition to underrepresented groups within medicine and other fields. Inspired by the wide-reaching social media campaign of #ILookLikeASurgeon to promote female physicians, members of the Society for Women in Radiation Oncology penned a new hashtag and launched the #WomenWhoCurie social media campaign on Marie Curie's birthday November 7th, as part of their strategy to raise public awareness. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460226PMC
January 2019
1 Read

Stereotactic MR-Guided Online Adaptive Radiation Therapy (SMART) for Ultracentral Thorax Malignancies: Results of a Phase 1 Trial.

Adv Radiat Oncol 2019 Jan-Mar;4(1):201-209. Epub 2018 Oct 18.

Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri.

Purpose: Stereotactic body radiation therapy (SBRT) is an effective treatment for oligometastatic or unresectable primary malignancies, although target proximity to organs at risk (OARs) within the ultracentral thorax (UCT) limits safe delivery of an ablative dose. Stereotactic magnetic resonance (MR)-guided online adaptive radiation therapy (SMART) may improve the therapeutic ratio using reoptimization to account for daily variation in target and OAR anatomy. This study assessed the feasibility of UCT SMART and characterized dosimetric and clinical outcomes in patients treated for UCT lesions on a prospective phase 1 trial. Read More

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http://dx.doi.org/10.1016/j.adro.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349650PMC
October 2018
1 Read

Big Data Readiness in Radiation Oncology: An Efficient Approach for Relabeling Radiation Therapy Structures With Their TG-263 Standard Name in Real-World Data Sets.

Adv Radiat Oncol 2019 Jan-Mar;4(1):191-200. Epub 2018 Oct 12.

Australian Institute of Health Innovation, Macquarie University, Sydney, Australia.

Purpose: To prepare for big data analyses on radiation therapy data, we developed a tool-supported approach for standardization of structure names in existing radiation therapy plans. We applied the widely endorsed nomenclature standard TG-263 as the mapping target and quantified the structure name inconsistency in 2 real-world data sets.

Methods And Materials: The clinically relevant structures in the radiation therapy plans were identified by reference to randomized controlled trials. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349627PMC
October 2018
1 Read

Nonuniform Planning Target Volume Margins for Prostate Bed on the Basis of Surgical Clips on Daily Cone Beam Computed Tomography.

Adv Radiat Oncol 2019 Jan-Mar;4(1):186-190. Epub 2018 Oct 12.

Duke University Medical Center, Department of Radiation Oncology, Durham, North Carolina.

Purpose: We hypothesized that the interfraction motions of the superior and inferior prostate beds differ and therefore require different margins. In this study, we used daily cone beam computed tomography (CBCT) to evaluate the motion of postprostatectomy surgical clips (separated to superior and inferior portions) within the planning target volume (PTV) to derive data-driven PTV margins.

Methods And Materials: Our study cohort included consecutive patients with identifiable surgical clips undergoing prostate bed irradiation with daily CBCT image guidance. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349621PMC
October 2018
1 Read

Evaluation of Image Registration Accuracy for Tumor and Organs at Risk in the Thorax for Compliance With TG 132 Recommendations.

Adv Radiat Oncol 2019 Jan-Mar;4(1):177-185. Epub 2018 Sep 7.

Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia.

Purpose: To evaluate accuracy for 2 deformable image registration methods (in-house B-spline and MIM freeform) using image pairs exhibiting changes in patient orientation and lung volume and to assess the appropriateness of registration accuracy tolerances proposed by the American Association of Physicists in Medicine Task Group 132 under such challenging conditions via assessment by expert observers.

Methods And Materials: Four-dimensional computed tomography scans for 12 patients with lung cancer were acquired with patients in prone and supine positions. Tumor and organs at risk were delineated by a physician on all data sets: supine inhale (SI), supine exhale, prone inhale, and prone exhale. Read More

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http://dx.doi.org/10.1016/j.adro.2018.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349597PMC
September 2018

FMEA of MR-Only Treatment Planning in the Pelvis.

Adv Radiat Oncol 2019 Jan-Mar;4(1):168-176. Epub 2018 Sep 7.

Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan.

Purpose: To evaluate the implementation of a magnetic resonance (MR)-only workflow (ie, implementing MR simulation as the primary planning modality) using failure mode and effects analysis (FMEA) in comparison with a conventional multimodality (MR simulation in conjunction with computed tomography simulation) workflow for pelvis external beam planning.

Methods And Materials: To perform the FMEA, a multidisciplinary 9-member team was assembled and developed process maps, identified potential failure modes (FMs), and assigned numerical values to the severity (S), frequency of occurrence (O), and detectability (D) of those FMs. Risk priority numbers (RPNs) were calculated via the product of S, O, and D as a metric for evaluating relative patient risk. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24521094183017
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http://dx.doi.org/10.1016/j.adro.2018.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349599PMC
September 2018
6 Reads

Fixed- versus Variable-RBE Computations for Intensity Modulated Proton Therapy.

Adv Radiat Oncol 2019 Jan-Mar;4(1):156-167. Epub 2018 Dec 13.

Department of Radiation Physics, The University of Texas MD Anderson Cancer, Houston, Texas.

Purpose: To evaluate how using models of proton therapy that incorporate variable relative biological effectiveness (RBE) versus the current practice of using a fixed RBE of 1.1 affects dosimetric indices on treatment plans for large cohorts of patients treated with intensity modulated proton therapy (IMPT).

Methods And Materials: Treatment plans for 4 groups of patients who received IMPT for brain, head-and-neck, thoracic, or prostate cancer were selected. Read More

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http://dx.doi.org/10.1016/j.adro.2018.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349601PMC
December 2018
1 Read

Use of the AAPM Safety Profile Assessment Tool to Evaluate the Change in Safety Culture After Implementing the RABBIT Prospective Risk Management System.

Adv Radiat Oncol 2019 Jan-Mar;4(1):150-155. Epub 2018 Aug 23.

Cancer Care Centre, St George Hospital, Kogarah, New South Wales, Australia.

Purpose: Hospitals traditionally focus on reactive risk management such as incident reporting, but prospective risk management systems such as failure modes and effects analysis are also important tools to reduce risks and improve the safety culture. In 2015, the St George Cancer Care Centre (STGCCC) developed a multidisciplinary risk-based system for the safe and effective implementation of new technologies and techniques, using risk and benefit balance impact templates (RABBIT) developed in-house. The purpose of this study was to determine whether risk management and the safety culture in radiation oncology were perceived to have improved since the introduction of the RABBIT system. Read More

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http://dx.doi.org/10.1016/j.adro.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349626PMC

A Multi-Institutional Experience of MR-Guided Liver Stereotactic Body Radiation Therapy.

Adv Radiat Oncol 2019 Jan-Mar;4(1):142-149. Epub 2018 Aug 23.

Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Purpose: Daily magnetic resonance (MR)-guided radiation has the potential to improve stereotactic body radiation therapy (SBRT) for tumors of the liver. Magnetic resonance imaging (MRI) introduces unique variables that are untested clinically: electron return effect, MRI geometric distortion, MRI to radiation therapy isocenter uncertainty, multileaf collimator position error, and uncertainties with voxel size and tracking. All could lead to increased toxicity and/or local recurrences with SBRT. Read More

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http://dx.doi.org/10.1016/j.adro.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349638PMC
August 2018
2 Reads

International Survey on the Use of Complementary and Alternative Medicines for Common Toxicities of Radiation Therapy.

Adv Radiat Oncol 2019 Jan-Mar;4(1):134-141. Epub 2018 Oct 5.

Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Purpose: Complementary and alternative medicines (CAMs) are widely used by patients with cancer. However, little is known about the extent to which these potential remedies are used internationally to treat the most common toxicities of radiation therapy. We report on the results of an international survey that assessed the use of CAMs. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349625PMC
October 2018
1 Read

Impact of Performance Status and Comorbidity on Palliative Radiation Treatment Tolerance and End-Of-Life Decision-Making.

Adv Radiat Oncol 2019 Jan-Mar;4(1):127-133. Epub 2018 Sep 14.

Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.

Purpose: Previous studies have indicated a relationship between functional status and comorbidity on overall survival when treating patients with bone and brain metastases. However, the degree to which these findings have been integrated into modern-day practice remains unknown. This study examines the impact of performance measures, including Karnofsky Performance Status (KPS) and comorbidity, on palliative radiation therapy treatment tolerance and fractionation schedule. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349604PMC
September 2018

Predictors of the Predominance of NonIndex Pain After Palliative Radiation Therapy for Painful Tumors.

Adv Radiat Oncol 2019 Jan-Mar;4(1):118-126. Epub 2018 Aug 23.

Department of Radiation Oncology, Kumamoto University Hospital, Kumamoto, Japan.

Purpose: Even when index pain (pain caused by the irradiated tumor) is palliated after radiation therapy (RT), patients may not derive the full benefits of RT in the presence of another, more intense pain. In this case-control study with prospectively collected data, we sought to identify predictors of the predominance of nonindex pain after palliative RT.

Methods And Materials: Brief Pain Inventory data were collected from patients who received RT for painful tumors. Read More

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http://dx.doi.org/10.1016/j.adro.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349584PMC

The Safety Profile of Concurrent Therapy for Multiple Myeloma in the Modern Era.

Adv Radiat Oncol 2019 Jan-Mar;4(1):112-117. Epub 2018 Sep 27.

Department of Radiation Oncology, Mount Sinai Hospital, New York, New York.

Purpose: The management of multiple myeloma has evolved in the modern era, partially owing to the increasing number of biologic therapeutics. Nonetheless, radiation remains an important treatment in the management of painful lytic lesions from multiple myeloma. The goal of this study is to evaluate the side effect profile of radiation therapy (RT) while patients are concurrently treated with biologic agents. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349658PMC
September 2018
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Transitioning From a Low-Dose-Rate to a High-Dose-Rate Prostate Brachytherapy Program: Comparing Initial Dosimetry and Improving Workflow Efficiency Through Targeted Interventions.

Adv Radiat Oncol 2019 Jan-Mar;4(1):103-111. Epub 2018 Oct 23.

Department of Radiation Oncology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.

Purpose: We transitioned from a low-dose-rate (LDR) to a high-dose-rate (HDR) prostate brachytherapy program. The objective of this study was to describe our experience developing a prostate HDR program, compare the LDR and HDR dosimetry, and identify the impact of several targeted interventions in the HDR workflow to improve efficiency.

Methods And Materials: We performed a retrospective cohort study of patients treated with LDR or HDR prostate brachytherapy. Read More

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http://dx.doi.org/10.1016/j.adro.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349651PMC
October 2018
2 Reads

The Perineural Invasion Paradox: Is Perineural Invasion an Independent Prognostic Indicator of Biochemical Recurrence Risk in Patients With pT2N0R0 Prostate Cancer? A Multi-Institutional Study.

Adv Radiat Oncol 2019 Jan-Mar;4(1):96-102. Epub 2018 Sep 19.

University of Southern California, Keck School of Medicine, Department of Radiation Oncology, Los Angeles, California.

Purpose: Perineural invasion (PNI) is a histologic feature that is present in as many as 84% of patients with prostate cancer. The prognostic significance of PNI is controversial, with recent studies yielding contradictory results. This study aims to assess whether PNI, on the surgical pathology of patients with pT2N0M0 disease and with negative surgical margins, is an independent prognostic indicator of the risk of biochemical recurrence. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349660PMC
September 2018

Prostate Stereotactic Body Radiation Therapy With a Focal Simultaneous Integrated Boost: Acute Toxicity and Dosimetry Results From a Prospective Trial.

Adv Radiat Oncol 2019 Jan-Mar;4(1):90-95. Epub 2018 Sep 19.

University of Alabama at Birmingham, Department of Radiation Oncology, Birmingham, Alabama.

Purpose: This study aimed to report the early toxicity results of a prospective clinical trial of prostate stereotactic body radiation therapy (SBRT) to the entire prostate with a simultaneous integrated boost (SIB) to magnetic resonance imaging (MRI)-defined focal lesions.

Methods And Materials: Eligible patients included men with biopsy-proven prostate stage T1c to T2c adenocarcinoma, a Gleason score ≤7, and prostate-specific antigen values of ≤20 ng/mL, who had at least 1 focal lesion visible on MRI and a total prostate volume no greater than 120 cm. SBRT consisted of a dose of 36. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349624PMC
September 2018
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Percutaneous Image-Guided Nodal Biopsy After 11C-Choline PET/CT for Biochemically Recurrent Prostate Cancer: Imaging Predictors of Disease and Clinical Implications.

Adv Radiat Oncol 2019 Jan-Mar;4(1):79-89. Epub 2018 Sep 5.

Department of Radiology, Mayo Clinic, Rochester, Minnesota.

Purpose: Management of recurrent prostate cancer necessitates timely diagnosis and accurate localization of the sites of recurrent disease. The purpose of this study was to assess predictors of histologic outcomes after 11C-choline positron emission tomography/computed tomography (CholPET) to increase the positive predictive value and specificity of CholPET in identifying imaging predictors of malignant and benign nodal disease to better inform clinical decision making regarding local therapy planning.

Materials And Methods: Retrospective review of patients undergoing CholPET followed by percutaneous core needle biopsy between January 1, 2010 and January 1, 2016. Read More

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http://dx.doi.org/10.1016/j.adro.2018.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349661PMC
September 2018
2 Reads

Analysis of Gastrointestinal Toxicity in Patients Receiving Proton Beam Therapy for Prostate Cancer: A Single-Institution Experience.

Adv Radiat Oncol 2019 Jan-Mar;4(1):70-78. Epub 2018 Aug 13.

Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington.

Purpose: We characterized both physician- and patient-reported rates of gastrointestinal (GI) toxicity in patients treated with proton beam therapy (PBT) at our institution for prostate adenocarcinoma and identified factors associated with toxicity.

Methods And Materials: We treated 192 patients with PBT between July 2013 and July 2016. Included patients had ≥1 year of follow-up. Read More

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http://dx.doi.org/10.1016/j.adro.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349581PMC
August 2018
2 Reads

A Comparison of Grade 4 Lymphopenia With Proton Versus Photon Radiation Therapy for Esophageal Cancer.

Adv Radiat Oncol 2019 Jan-Mar;4(1):63-69. Epub 2019 Jan 17.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: Grade 4 lymphopenia (G4L) during radiation therapy (RT) is associated with higher rates of distant metastasis and decreased overall survival in a number of malignancies, including esophageal cancer (EC). Through a reduction in integral radiation dose, proton RT (PRT) may reduce G4L relative to photon RT (XRT). The purpose of this study was to compare G4L in patients with EC undergoing PRT versus XRT. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349594PMC
January 2019

Stereotactic Ablative Radiation Therapy for Unresectable Colorectal Oligometastases.

Adv Radiat Oncol 2019 Jan-Mar;4(1):57-62. Epub 2018 Sep 14.

Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Purpose: Patients with oligometastatic colorectal cancer have demonstrated excellent clinical outcomes with surgical resection of hepatic and pulmonary metastases. Stereotactic ablative radiation therapy (SABR) has emerged as an alternative local therapy for nonsurgical candidates. Herein, we report the oncologic and patient-reported quality-of-life (PR-QoL) outcomes for a subset of patients with oligometastatic colorectal cancer who were treated in a prospective phase 2 multicenter clinical trial. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349603PMC
September 2018
1 Read

Intensity Modulated Radiation Therapy Versus Volumetric Arc Radiation Therapy in the Treatment of Glioblastoma-Does Clinical Benefit Follow Dosimetric Advantage?

Adv Radiat Oncol 2019 Jan-Mar;4(1):50-56. Epub 2018 Sep 28.

Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.

Purpose: Volumetric modulated arc therapy (VMAT) has been shown by multiple planning studies to hold dosimetric advantages over intensity modulated radiation therapy (IMRT) in the management of brain tumors, including glioblastoma (GBM). Although promising, the clinical impact of these findings has not been fully elucidated.

Methods And Materials: We retrospectively reviewed consecutive patients with a pathologic-confirmed diagnosis of GBM who were treated between 2014 and 2015, a period that encompassed the transition from IMRT to VMAT at a single institution. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349632PMC
September 2018
1 Read

Analysis of MRI Volumetric Changes After Hypofractionated Stereotactic Radiation Therapy for Benign Intracranial Neoplasms.

Adv Radiat Oncol 2019 Jan-Mar;4(1):43-49. Epub 2018 Aug 23.

Department of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona.

Purpose: To quantitatively assess volumetric changes after hypofractionated stereotactic radiation therapy (HFSRT) in patients treated for vestibular schwannomas and meningiomas.

Methods And Materials: We retrospectively reviewed records of patients treated with HFSRT at our institution from 2002 to 2014. Patients received a median dose of 25 Gy in 5 fractions. Read More

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http://dx.doi.org/10.1016/j.adro.2018.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349623PMC
August 2018
1 Read

The Lack of Consensus of International Contouring Guidelines for the Dorsal Border of the Chest Wall Clinical Target Volume: What is the Impact on Organs at Risk and Relationships to Patterns of Recurrence in the Modern Era?

Adv Radiat Oncol 2019 Jan-Mar;4(1):35-42. Epub 2018 Sep 27.

Department of Radiation Oncology, West Virginia University, Morgantown, West Virginia.

Purpose: Variation exists in cooperative group recommendations for the dorsal border for the chest wall clinical target volume (CTV). We aimed to quantify the impact of this variation on doses to critical organs and examine patterns of chest wall recurrence relative to the pectoralis muscle.

Methods And Materials: We retrospectively assessed patterns of chest wall recurrence quantified to the recommended CTV borders for women treated between 2005 and 2017. Read More

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http://dx.doi.org/10.1016/j.adro.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349659PMC
September 2018

Radiation Recall Dermatitis After the Use of Pralatrexate for Peripheral T-cell Lymphoma.

Adv Radiat Oncol 2019 Jan-Mar;4(1):31-34. Epub 2018 Oct 12.

Department of Dermatology, Mayo Clinic, Phoenix, Arizona.

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http://dx.doi.org/10.1016/j.adro.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349631PMC
October 2018
1 Read