566 results match your criteria Advances in nephrology from the Necker Hospital[Journal]


Angiotensin-induced inflammation and novel approaches to treatment.

Adv Nephrol Necker Hosp 2001 ;31:89-103

Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin.

In a brief period, we have accrued a new view of Ang II. From conventional signaling pathways, our attention was directed toward signal transduction involving specific tyrosine kinases, inducing not only vasocontriction but also proto-oncogene expression, protein synthesis, hypertrophy and growth. More recently, our attention has been directed beyond these effects to inflammatory reactions involving NF-kappa B activation and related gene expression. Read More

View Article

Download full-text PDF

Source

Renal fibrosis and the renin-angiotensin system.

Authors:
A B Fogo

Adv Nephrol Necker Hosp 2001 ;31:69-87

Vanderbilt University School of Medicine, Renal/EM Laboratory, Vanderbilt University Medical Center, Nashville, Tenn., USA.

These data demonstrate that regression of biopsy-proven glomerulosclerosis can be achieved in various experimental settings. The potential importance of the RAS in renal fibrosis is underscored by the effectiveness of therapies that aim to inhibit its manifold actions, including induction of PAI-1. An understanding of the interactions of the RAS with the immune response, aldosterone, and PAI-1, as well as the dynamic control of cell proliferation, apoptosis, and regeneration, is now evolving. Read More

View Article

Download full-text PDF

Source

What is the optimal blood pressure target in renal patients?

Adv Nephrol Necker Hosp 2001 ;31:43-53

Universidad Complutense de Madrid, Hypertension Unit, 12 Octubre Hospital, Madrid.

Chronic renal failure and arterial hypertension run in parallel. New goal BP levels have been established as 130/85 mm Hg and 125/75 mm Hg, depending on whether the level of proteinuria is less than or greater than 1 g/d. New and lower threshold BP (> 130/85 mm Hg) to initiate pharmacologic therapy is required in the presence of renal failure, to facilitate the strict BP control that is required. Read More

View Article

Download full-text PDF

Source

Fabry disease: clinical features and recent advances in enzyme replacement therapy.

Adv Nephrol Necker Hosp 2001 ;31:317-39

Department of Human Genetics, Mount Sinai School of Medicine of New York University, New York, USA.

View Article

Download full-text PDF

Source
March 2002
1 Read

Genetics of diabetic nephropathy: how far are we from finding susceptibility genes?

Adv Nephrol Necker Hosp 2001 ;31:295-315

Harvard Medical School, Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, USA.

View Article

Download full-text PDF

Source

Complement deficiencies, lupus and apoptosis.

Authors:
H T Cook

Adv Nephrol Necker Hosp 2001 ;31:29-41

Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London.

View Article

Download full-text PDF

Source

Nephrotoxicity of immunosuppressive agents.

Adv Nephrol Necker Hosp 2001 ;31:285-93

University of Leuven, Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium.

View Article

Download full-text PDF

Source

Renal senescence, cellular senescence, and their relevance to nephrology and transplantation.

Authors:
P F Halloran A Melk

Adv Nephrol Necker Hosp 2001 ;31:273-83

Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada.

View Article

Download full-text PDF

Source

Hematopoietic stem cells: therapeutic applications in autoimmune diseases and in solid organ transplantation.

Adv Nephrol Necker Hosp 2001 ;31:257-72

Department of Immunology, Hematology, and Transfusion, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

View Article

Download full-text PDF

Source

Repair of glomerular inflammation.

Adv Nephrol Necker Hosp 2001 ;31:243-56

University Pierre et Marie Curie, Service d'Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, Paris.

View Article

Download full-text PDF

Source

Podocyte biology: a footstep further.

Adv Nephrol Necker Hosp 2001 ;31:235-41

Department of Medicine, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

View Article

Download full-text PDF

Source

Nephrin: role in normal kidney and in disease.

Authors:
K Tryggvason

Adv Nephrol Necker Hosp 2001 ;31:221-34

Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm.

View Article

Download full-text PDF

Source

Phagocyte clearance of cells dying by apoptosis and the regulation of glomerular inflammation.

Authors:
J Savill

Adv Nephrol Necker Hosp 2001 ;31:21-8

University of Edinburgh Medical School, Royal Infirmary of Edinburgh, Scotland.

View Article

Download full-text PDF

Source

The beat of hemodialysis: frequent, prolonged, or frequent and prolonged?

Adv Nephrol Necker Hosp 2001 ;31:207-20

Stichting Dianet Dialysis Centres, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source

Which patients benefit from angioplasty?

Authors:
J E Scoble

Adv Nephrol Necker Hosp 2001 ;31:193-205

Guy's and St. Thomas' NHS Trust, London, England.

View Article

Download full-text PDF

Source

Neutrophil function in renal failure.

Authors:
W H Hörl

Adv Nephrol Necker Hosp 2001 ;31:173-92

Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna.

View Article

Download full-text PDF

Source

Neutrophil biology in relation to renal diseases.

Adv Nephrol Necker Hosp 2001 ;31:153-71

INSERM U 507, Hôpital Necker, Paris.

View Article

Download full-text PDF

Source

Leptin and chronic renal failure.

Adv Nephrol Necker Hosp 2001 ;31:135-51

Université Bordeaux II-Victor Ségalen, Service de Néphrologie, Hôpital Pellegrin, Bordeaux, France.

View Article

Download full-text PDF

Source

Central control of bone formation.

Authors:
G Karsenty

Adv Nephrol Necker Hosp 2001 ;31:119-33

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA.

View Article

Download full-text PDF

Source

Polymorphisms in the genes of the renin system and progression of renal disease: a critical review.

Adv Nephrol Necker Hosp 2001 ;31:105-17

CNR Centro Fisiologia Clinica & Unità Operativa di Nefrologia, Dialisi e Trapianto Renale, Reggio Cal, Italy.

View Article

Download full-text PDF

Source

Control of apoptosis: therapeutic implications.

Adv Nephrol Necker Hosp 2001 ;31:1-19

Cochin Institute of Molecular Genetics, Paris.

View Article

Download full-text PDF

Source

Autosomal-dominant chronic interstitial nephritis with early hyperuricemia.

Adv Nephrol Necker Hosp 2000 ;30:357-69

Nephrology Unit, Université Catholique de Louvain, Brussels, Belgium.

View Article

Download full-text PDF

Source
February 2001

Extraskeletal calcification in patients with chronic kidney failure.

Adv Nephrol Necker Hosp 2000 ;30:333-56

INSERM Unit 507, Hôpital Necker, Paris, France.

View Article

Download full-text PDF

Source
February 2001

Glomerular involvement in lymphoproliferative disorders with hyperproduction of cytokines (Castleman, POEMS).

Adv Nephrol Necker Hosp 2000 ;30:305-31

Service de Néphrologie, Hôpital Necker, Paris, France.

View Article

Download full-text PDF

Source
February 2001

Endothelin, renal diseases, and hypertension.

Adv Nephrol Necker Hosp 2000 ;30:281-303

Université Paris VI, France.

View Article

Download full-text PDF

Source
February 2001

Hemolytic-uremic syndrome: hereditary forms and forms associated with hereditary diseases.

Adv Nephrol Necker Hosp 2000 ;30:261-80

University René Descartes, Paris V, France.

View Article

Download full-text PDF

Source
February 2001

Thrombotic microangiopathies: renal and extrarenal lesions.

Adv Nephrol Necker Hosp 2000 ;30:235-59

Service de Néphrologie, Hôpital Necker, Paris, France.

View Article

Download full-text PDF

Source
February 2001

Intravenous immunoglobulins and kidney transplantation in patients with anti-HLA antibodies.

Adv Nephrol Necker Hosp 2000 ;30:221-33

Transplantation Unit, Hôpital Européen Georges Pompidou, Paris, France.

View Article

Download full-text PDF

Source
February 2001

Lipoproteins and vascular changes in chronic kidney failure.

Authors:
C Wanner

Adv Nephrol Necker Hosp 2000 ;30:215-20

University of Würzburg, Germany.

View Article

Download full-text PDF

Source
February 2001
1 Read

Inflammation and oxidative stress in end-stage renal disease.

Authors:
G A Kaysen

Adv Nephrol Necker Hosp 2000 ;30:201-14

Department of Medicine, University of California, Davis, USA.

View Article

Download full-text PDF

Source
February 2001

Atherosclerotic complications in chronic renal failure: epidemiology and predictive factors.

Adv Nephrol Necker Hosp 2000 ;30:177-99

University René-Descartes, Paris, France.

View Article

Download full-text PDF

Source
February 2001

Inherited hypomagnesemia.

Adv Nephrol Necker Hosp 2000 ;30:163-76

University Medical Center St Radboud, The Netherlands.

View Article

Download full-text PDF

Source
February 2001

Inherited renal tubular acidosis.

Authors:
F E Karet

Adv Nephrol Necker Hosp 2000 ;30:147-62

Department of Nephrology, Wellcome Trust Centre for Molecular Mechanisms in Disease, Addenbrooke's Hospital, University of Cambridge, England.

View Article

Download full-text PDF

Source
February 2001

Physiopathologic role of cubilin and megalin.

Adv Nephrol Necker Hosp 2000 ;30:127-45

INSERM Unit 538, CHU Saint Antoine, Paris, France.

View Article

Download full-text PDF

Source
February 2001

Endocytosis.

Adv Nephrol Necker Hosp 2000 ;30:109-25

GeneSoft, Inc, South San Francisco, Calif., USA.

View Article

Download full-text PDF

Source
February 2001

Juxtaglomerular apparatus, nitric oxide, and macula densa signaling.

Adv Nephrol Necker Hosp 2000 ;30:95-107

Humboldt University, Berlin, Germany.

View Article

Download full-text PDF

Source
February 2001

Treatment of adult hemolytic-uremic syndrome.

Adv Nephrol Necker Hosp 2000 ;30:83-94

Department of Renal Medicine, Mario Negri Institute for Pharmacological Research-Negri Bergamo Laboratories, Italy.

View Article

Download full-text PDF

Source
February 2001

von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome.

Authors:
M Furlan

Adv Nephrol Necker Hosp 2000 ;30:71-81

University of Bern School of Medicine, Switzerland.

View Article

Download full-text PDF

Source
February 2001

Mycophenolate mofetil: therapeutic potential in renal diseases.

Adv Nephrol Necker Hosp 2000 ;30:57-69

Claude-Bernard University, Lyon, France.

View Article

Download full-text PDF

Source
February 2001
2 Reads

Pathophysiology of edema and acute renal failure in idiopathic nephrotic syndrome.

Authors:
H A Koomans

Adv Nephrol Necker Hosp 2000 ;30:41-55

Department of Nephrology, University Medical Center Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
February 2001
2 Reads

Clinical importance of HLA-specific and non-HLA-specific antibodies in allogeneic kidney transplantation.

Authors:
S Sumitran

Adv Nephrol Necker Hosp 2000 ;30:29-39

Karolinska Institute, Sweden.

View Article

Download full-text PDF

Source
February 2001

Immunosuppressive strategies in renal transplantation at the beginning of the third millennium.

Adv Nephrol Necker Hosp 2000 ;30:9-28

Université Libre de Bruxelles, Belgium.

View Article

Download full-text PDF

Source
February 2001

Dry weight in dialysis patients.

Adv Nephrol Necker Hosp 2000 ;30:1-7

University of Maastricht, Academic Hospital of Maastricht, The Netherlands.

View Article

Download full-text PDF

Source
February 2001

Human malformation syndromes: lessons in kidney differentiation.

Adv Nephrol Necker Hosp 1999 ;29:329-39

Nephrourology Unit, University College London Medical School, England.

View Article

Download full-text PDF

Source
November 1999

Pax2 in the development of renal and urinary tract diseases.

Adv Nephrol Necker Hosp 1999 ;29:317-27

Service de Néphrologie, Hôpital Necker-Enfants Malades, Paris, France.

View Article

Download full-text PDF

Source
November 1999

WT1, renal development, and glomerulopathies.

Adv Nephrol Necker Hosp 1999 ;29:299-315

INSERM U.423, Hôpital Necker-Enfants Malades, Université René Descartes, Paris, France.

View Article

Download full-text PDF

Source
November 1999

Chloride channels in renal disease.

Authors:
R V Thakker

Adv Nephrol Necker Hosp 1999 ;29:289-98

MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England.

Recent studies of hereditary renal tubular disorders have facilitated the identification and roles of chloride channels and cotransporters in the regulation of the most abundant anion, Cl-, in the ECF. Thus, mutations that result in a loss of function of the voltage-gated chloride channel, CLC-5, are associated with Dent's disease, which is characterized by low-molecular weight proteinuria, hypercalciuria, nephrolithiasis, and renal failure. Mutations of another voltage-gated chloride channel, CLC-Kb, are associated with a form of Bartter's syndrome, whereas other forms of Bartter's syndrome are caused by mutations in the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC2) and the potassium channel, ROMK. Read More

View Article

Download full-text PDF

Source
November 1999
2 Reads

Autosomal dominant polycystic kidney disease, type 2 (PKD2 disease).

Authors:
R Torra

Adv Nephrol Necker Hosp 1999 ;29:277-87

Department of Nephrology, Hospital Clínic, Barcelona, Spain.

View Article

Download full-text PDF

Source
November 1999

The PKD2 gene: structure, interactions, mutations, and inactivation.

Authors:
S Somlo

Adv Nephrol Necker Hosp 1999 ;29:257-75

Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
November 1999
1 Read