2 results match your criteria Advances in medicine and biology[Journal]

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Haploinsufficient tumor suppressor genes.

Adv Med Biol 2017 1st Quarter;118:83-122

The Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157 USA.

Haploinsufficiency of tumor suppressor genes (TSGs) indicates that the reduced levels of proteins in cells that lack one allele of the genomic locus results in the inability of the cell to execute normal cellular functions contributing to tumor development. Representative cases of haploinsufficient TSGs are and . Tumor development is significantly accelerated in both mice with homozygous and heterozygous gene deletion, with expression of the wild type allele in the latter. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494974PMC
July 2017
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Analysis of Drug Interactions with Lipoproteins by High-Performance Affinity Chromatography.

Adv Med Biol 2012 ;53:199-216

Department of Chemistry University of Nebraska Lincoln, NE 68588-0304 (USA).

Lipoproteins such as high-density lipoprotein (HDL) and low-density lipoprotein (LDL) are known to interact with drugs and other solutes in blood. These interactions have been examined in the past by methods such as equilibrium dialysis and capillary electrophoresis. This chapter describes an alternative approach that has recently been developed for examining these interactions by using high-performance affinity chromatography. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225721PMC
January 2012
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