1,522 results match your criteria Advances in gerontology = Uspekhi gerontologii[Journal]


[Brenda Milner: 100 years from the birthday.]

Adv Gerontol 2018;31(5):798-804

Yaroslav-the-Wise Novgorod State University, 41, Bolshaya Saint-Petersburg str., Velikiy Novgorod 173003, Russian Federaion.

Brenda Milner is a renowned British-Canadian neuropsychologist known as «the founder of neuropsychology». She was born about 100 years ago, and as a Cambridge graduate, she started her research carreer of a neurobiologist and psychologist in 1940s. Her comprehensive contribution to the development of clinical neuropsychology thereafter was marked by several awards including the Balzan Prize for Cognitive Neuroscience in 2009 and the Kavli Prize in Neuroscience in 2014 (shared with Marcus Raichle and John O'Keefe), as well as memberships in the Royal Society of London, the Royal Society of Canada and the National Academy of Sciences. Read More

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January 2018

[Particularities of preferential provision of medicines of elderly patients in Privolzhsky Federal District.]

Adv Gerontol 2018;31(5):789-797

Samara State Medical University, 89, Chapaevskaya ul., Samara 443099, Russian Federation; e-mail:

To identify trends in the sector of preferential provision of medicines in the pharmaceutical market of the Privolzhsky Federal District (PFD) an analysis of the implementation of the provision of essential medicines program, funded from the federal budget, was carried out. It has been established that in the structure of the total costs for the implementation of the provision of essential medicines program in the PFD a significant amount of funds (from 83 to 90%) are on the medicine provision of persons with I, II and III disability categories with about 74% of benefit recipients belonging to the age group over 60 years. The leading positions in overall consumption in monetary terms belong the medicines prescribed for the treatment of diabetes mellitus, oncological diseases and bronchial asthma. Read More

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January 2018

[The elderly as witnesses of three epochs: from socialism to the market.]

Adv Gerontol 2018;31(5):780-788

Saint Petersburg State University, 7-9, Universitetskaya nab., St. Petersburg 199034, Russian Federation; e-mail:

The article examines the specificity of the elderly social memory as witnesses of three epoch. Modern elderly have a unique experience that allows them to look at the social and economic situation in the country from the perspective of the past epochs of the soviet time, perestroika and market period. The research was carried out with the help of biographical method based on in-depth semi-structured interviewing. Read More

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January 2018
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[Morphology and cytoarchitectonics of the popliteal lymph node in people of senile age.]

Adv Gerontol 2018;31(5):774-779

Research Institute of Human Morphology, 3, Tsurupy str., Moscow 117418, Russian Federation; e-mail:

Histological methods were used to study popliteal lymph nodes in 10 people in senile age (80-91 years). Deep destructive changes of the reticular stroma were noted. The content of cells in the node is sharply reduced. Read More

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January 2018

[Evaluation of the effectiveness of rehabilitation of elderly patients with metabolic syndrome, taking into account the provisions of International classification of functioning, disability and health.]

Adv Gerontol 2018;31(5):768-773

G.A.Albrecht Federal Scientific Center of Rehabilitation of the Disabled, 50, Bestuzhevskaya str., St. Petersburg 195067, Russian Federation; e-mail:

The article contains data on rehabilitation measures in elderly patients with metabolic syndrome. Individual-oriented treatment and rehabilitation programs implemented in primary health care allow to reliably reduce the severity and risk of progression of restrictions of life, increase the independence of patients The elderly, having metabolic syndrome, complicated the development of type 2 diabetes mellitus. It is proposed to assess the effectiveness of rehabilitation, taking into account the provisions of the International Classification of functioning, restrictions on life and health and by drawing up an individual geriatric profile. Read More

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January 2018
7 Reads

[Prevalence and determinants of bone remodelancy disorders in patients with diabetes.]

Authors:
S S Safarova

Adv Gerontol 2018;31(5):760-766

Azerbaijan Medical University, 23, Bakikhanov str., Baku, Azerbaijan AZ1022; e-mail:

The article presents the results of structural change and functional state of bone in patients with diabetes mellitus. Total of 235 patients aged 40 to 70 years, of these, 98 (41 men, 57 women) type 1 and 137 (52 men, 85 women) type 2 diabetes patients were included in the study. DM1 duration 16,6±0,6 years, BMI: 26,1±0,2 kg/m2 and DM2: 8,1±0,7 years, BMI: 30±0,4 kg/m2. Read More

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January 2018
1 Read

[Characteristic of the behavioral response and cognitive evoked potentials at 60-74 aged women.]

Adv Gerontol 2018;31(5):751-759

Institute of Medical and Biological Research of M.V.Lomonosov Northern (Arctic) Federal University, 3, Badigin pr., Arkhangelsk 163045, Russian Federation; e-mail:

The article presents the results of the study of the characteristics of behavioral response and cognitive visual event related potentials in 90 elderly women. To analyze a behavioral reaction the computer complex KPFC-99 «PSYCHOMAT», which includes the computer test system Binatest (Moscow) was used. The event related potentials were registered for all participants with using of 128-channel system GES-300. Read More

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January 2018

[Quality of life and physical activity among elderly and old people.]

Adv Gerontol 2018;31(5):743-750

Saint-Petersburg Institute of Bioregulation and Gerontology, 3, Dinamo pr., St. Petersburg 197110, Russian Federation.

This article presents the results of the identification of the main causes of physical inactivity among the elderly and the assessment of the effectiveness of the inclusion of regular Nordic walking into the preventive system for the elderly in order to improve the quality of life. A comparative analysis of the quality of life was used among elderly and old people, regularly engaged in Nordic walking (intervention group) and leading a physically passive lifestyle (control group). It was established that regular physical activity allows the improvement of the quality of life and positively affects health in groups under study, but it is the elderly people who represent the most physically inactive part of the population. Read More

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January 2018
13 Reads

[Motivational inductors of behavior as reserves of successful aging.]

Adv Gerontol 2018;31(5):737-742

Novosibirsk State Technical University, 20, pr. K.Marksa, Novosibirsk 630073, Russian Federation; e-mail:

Aging-associated differences in motivational inducers of behavior the internal control of which promotes «successful» aging are studied. The study involved university students and elderly women (20±1,1 and 65,1±5,8 years, respectively). The dominance of cognitive activity in the profile of motivational inducers is established regardless of the age and time period of self-assessment. Read More

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January 2018

[Effect of tryptophan and kynurenine on the cellular proliferation in the organotypic tissue culture of brain cortex in young and old rats.]

Adv Gerontol 2018;31(5):732-736

Saint Petersburg Institute of Bioregulation and Gerontology, 3, pr. Dinamo, St. Petersburg 197110, Russian Federation; e-mail:

Metabolic disorders of L-kinurenin, which is an intermediate product of the breakdown of genetically encoded amino acid L-tryptophan, is one of the links in the development of a number of neuropathological processes. The influence of tryptophan and kynurenine on cell proliferation in organotypic tissue culture of the cerebral cortex in young and old rats was studied. Tryptophan in effective concentration (0,5 ng/ml) inhibited cellular proliferation of the cerebral cortex of young and old rats by 35 and 18%, respectively. Read More

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January 2018

[Prospects for the search for peptides for specific regulation of aging.]

Adv Gerontol 2018;31(5):717-731

Bashkir State University, 32, Zaki Validi str., Ufa 450076, Russian Federation.

We propose a hypothesis that the causes of aging are not random events, but regular processes due to the dysfunction of species-specific transposons. The hypothesis is justified by the fact that the average life expectancy differs significantly between species. In addition, genomes of different species differ in the composition and arrangement of transposons in them, which control the differentiation of cells in different tissues and at different stages of development. Read More

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January 2018

[Activity of α2-adrenergic and PAF receptors of platelets as risk factor of acute pyelonephritis during urolithiasis in eldery women.]

Authors:
E F Barinov

Adv Gerontol 2018;31(5):711-716

M.Gorkiy Donetsk national medical university, 16, pr. Il'yicha, Donetsk 83003, Ukraine; e-mail:

The aim of the study is to identify possible mechanisms that could provoke a recurrence of chronic obstructive pyelonephritis (COP) in eldery women, thus to find out - why age and sex can be risk factors for acute pyelonephritis in urolithiasis. The results of 43 women over 65 years of age (mean age 71±1,5 years) are presented in study. The 26 patients were examined in remission phase of COP; 17 patients were examined in recurrence phase. Read More

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January 2018
6 Reads

[Features of secondary prevention of cardiovascular disease in elderly individuals with high cardiovascular risk.]

Adv Gerontol 2018;31(5):707-710

Tyumen State Medical University, 54, Odesskaya str., Tyumen 625023, Russian Federation; e-mail:

Studied the causes of the ineffectiveness of follow-up of elderly patients with pathology of the cardiovascular system with high cardiovascular risk. The necessity of an individual approach, the individual preventive counseling in the usual patient conditions, learning to use tools of self-control belonging to that particular patient. Conducting a «pharmacological control» every visit to an elderly patient at home or a visit to the clinic. Read More

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January 2018

[Disadaptive disorders of regulation of functions at aging.]

Authors:
A A Artemenkov

Adv Gerontol 2018;31(5):696-706

Cherepovets State University, 5, pr. Lunacharskogo, Cherepovets 162600, Russian Federation; e-mail:

This review examines the basic theories of aging, showing the irreversibility of this process, leading to the death of cells and the body. The hypotheses of phenotype and apoptosis discussed, the opinion that disadaptation triggers free radical oxidation reactions and violates the neurohumoral regulation of functions. Briefly examines the mechanisms of development of diseases associated with aging. Read More

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January 2018

[The functional state of the external respiration system of long-livers of Pridnestrovie.]

Adv Gerontol 2018;31(5):691-695

T.G.Shevchenko Pridnestrovian State University, 128, 25 October str., Tiraspol, Moldova 3300-MD; e-mail:

The study of the functional state of the respiratory system of the majority of long-livers of Pridnestrovie was carried out for the first time. It was found that the main indicators of the functional state of the external respiration system (in percentage from proper value) of long-livers are not significantly different or slightly lower than in the representatives of the previous age group and do not differ between the representatives of the age groups of the long-livers 90-94 and 95-99 years; the magnitude of the vital index and life potential in long-livers is somewhat less than in the elderly, but they also do not change with the age of the long-livers, which indicates the slowed-down rates of the involuntary and degenerative processes in the system of external respiration in most long-livers. Read More

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January 2018
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[Stabilometric markers of biological age.]

Adv Gerontol 2018;31(5):684-690

Institute of Industrial Ecology, Ural Branch of RAS, 20, S.Kovalevskaya str., Ekaterinburg 620990, Russian Federation; e-mail:

The aim of this study was to find stabilometric parameters, the values of which correlate with chronological age. The results of the standard stabilometric test with open and closed eyes, which obtained during the examination of 87 people aged from 20 to 70 years, were considered. Basic, vector and frequency indicators of 618 tests (334 with open eyes and 284 with closed eyes) were analyzed. Read More

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January 2018

[Research of a psychoemotional condition of the elderly people having the confirmed oncological diagnosis.]

Adv Gerontol 2018;31(5):679-683

Novokuznetsk clinical oncological clinic, 25, Kutuzov str., Novokuznetsk 654041, Russian Federation.

The article presents results of research evaluating psychoemotional condition of patients with the malignant tumour diagnosis both single and having their family's support. The research results showed the difference in mood, health and general activity, situational anxiety and aggression. The received results can be considered when preparing elderly patients for operation and during the post operational period for the purpose of psychological maintenance and minimization of complications. Read More

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January 2018
1 Read

[Parkinson's disease and aging.]

Adv Gerontol 2018;31(5):668-678

I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, 44, Toreza pr., St. Petersburg 194223, Russian Federation; e-mail:

Parkinson's disease (PD) is one of the most severe human neurodegenerative diseases that is mainly represented by sporadic form with multifactorial nature and commonly diagnosed in persons over 65 years of age. Current data on molecular mechanisms of PD development and their connection with processes of aging have been given in the review. Mechanisms of conformational control and selective degradation of proteins in the cell, possible trigger factors initiating the cascade of pathological reactions have been analyzed. Read More

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January 2018
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[Neurochemical and morphological changes of microstructures of the compact part of the substantia nigra of human brain in aging and Parkinson's disease (literature review).]

Adv Gerontol 2018;31(5):662-667

Research center of neurology, 80, Volokolamskoye highway, Moscow 125367, Russian Federation; e-mail:

For investigation of pathogenetic patterns of Parkinson's disease, it is important to adequately assess the mechanisms of age-related involution and morphological changes that are formed in the brain during this process. Clinical symptoms, detected in Parkinson's disease (rigidity, hypokinesia, tremor), indicate the involvement in the pathological process of nigrostriate brain formations due to the death of dopamine neurons in the compact part of the substantia nigra. At the same time, the loss of these neurons, as well as the change in the number of neuroglia cells in the substantia nigra of the brain, are detected not only in Parkinson's disease, but also in physiological aging. Read More

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January 2018

[The decrease in the basal and luteinizing hormone receptor agonist-stimulated production of testosterone in aging male rats.]

Adv Gerontol 2018;31(5):654-661

I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, 44, pr. Toreza, St. Petersburg 194223, Russian Federation; e-mail:

The aging leads to a weakening of the steroid function of the testes and a decrease in their sensitivity to gonadotropins. However, the mechanisms of this are poorly understood. The aim of this work was to study the stimulating effects of human chorionic gonadotropin (hCG) and TP03, a low-molecular-weight agonist of luteinizing hormone (LH)/hCG receptor, on testosterone (T) production and the expression of steroidogenic proteins in young (3 months) and aging (15 months) male rats, and to investigate the activity of the adenylyl cyclase system in the membranes isolated from the testes of rats. Read More

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January 2018
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[Seasonal dynamics of physiological parameters in the elderly men living in the European North of Russia.]

Adv Gerontol 2018;31(5):648-653

Institute of Physiology, Komi Science Center, Ural Division of RAS, 50, Pervomayskaya str. Syktyvkar 167982, Russian Fedeartion; e-mail:

The study of physiological processes in the elderly people, especially in the chronobiological aspect, is of current interest. The subjects of the study were a group of elderly people (n=18, middle age 69,3±6,5 years), inhabitants of nursing house (Syktyvkar, 61о 04″ NL), who were surveyed 4 times within a year. The aim of the work was to study the dynamic of physiological parameters (anthropometric, cardio-respiratory, psychophysiological, e. Read More

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January 2018

[The role of constant light exposure in various periods of postnatal ontogenesis in the development of pathology and mortality in male rats.]

Adv Gerontol 2018;31(5):641-647

Petrozavodsk State University, 33, pr. Lenina, Petrozavodsk 185910, Russian Federation; e-mail:

The purpose of the experimental work was to study the effect of constant light, depending on the time of the onset of light exposure (from the age of one month or from fourteen months), on the development of age-related pathology and oncology in male rats. The results of the study show that decreased functional activity of the epiphysis due to the influence of constant light from the age of one month increases the incidence of inflammatory, non-tumor and tumor genesis diseases, and leads to the rapid development of age-related pathology. On the contrary, the onset of constant light exposure in male rats from the age of 14 months slows the development of age-related pathology, reduces the incidence and development of malignant tumors. Read More

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January 2018

[Regression of survivability variance upon cohort age in Drosophila melanogaster. II: Effects of geroprotective influences.]

Authors:
S V Mylnikov

Adv Gerontol 2018;31(5):632-640

Saint-Petersburg State University, 7-9, University emb., 199034 St. Petersburg, Russian Federation; e-mail:

We analyze the regression of survivability variance by cohort age in several generations of Drosophila melanogaster Canton-S stock. Three phases were detected. First and second was approximated by exponential equation and the third - by logistic dose-response curve. Read More

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January 2018

[Epigenetics of aging: a breakthrough direction in gerontology?]

Authors:
D E Jagarovi

Adv Gerontol 2018;31(5):628-631

Creative laboratory «Ipsc-lab», 0167, Georgia, Tbilisi, Gldani area, 2-31-179, e-mail:

Whereas genome is identical in all types of tissue and relatively stable during the lifetime, the epigenome of the multicellular organism changes during development and aging. The strong effects of age on one of the central epigenetic modifications - DNA cytosine methylation levels have been identified by Dr. B. Read More

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January 2018

[Where does the Preston curve lead us?]

Authors:
A G Golubev

Adv Gerontol 2018;31(5):616-627

N.N.Petrov National Medical Research Center of Oncology, 68, Leningradskaya srt., Pesochnyi, St. Petersburg, 197758, Russian Federation; e-mail:

World Bank and Russian Federal State Statistics Service data were used to analyze cross-country correlations between life expectancy (LE) and per capita gross domestic product (pcGDP). The resulting world trend (Preston curve) as of 2015 was compared with the trend revealed by plotting regional LE vs. pcGDP related to the major administrative areas of the Russian Federation (RF). Read More

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January 2018
11 Reads

[Investigation of internet-communities' influence on the social inclusion of the elderly people through leisure practices.]

Adv Gerontol 2018;31(4):597-603

Saint-Petersburg National Research University of Information Technologies, Mechanics and Optics, 49, Kronverksky pr., St. Petersburg, 197101, Russian Federation; e-mail:

Modern society is characterized by the intensification of new interactions and new communities, in parallel with the interest in social exclusion-inclusion topic. As the Internet develops, the research interest is directed to studying the specifics of emerging communities in a virtual environment called as «online communities», «virtual communities» etc. The article presents the results of studying 7 online communities of older people in the social network VKontakte about leisure. Read More

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January 2018

[On the correlation of guarantees of the labor rights of the elderly in Russia and Europe.]

Authors:
O N Bobrovskaya

Adv Gerontol 2018;31(4):588-596

I.M.Sechenov First Moscow State Medical University, 8, Trubetskaya str., Moscow, 119991, Russian Federation; e-mail:

Many lawyers, referring to the topic of guarantees for ensuring the labor rights of elderly people who receive a pension, begin the analysis from the provisions of Art. 19 of the Russian Constitution on the prohibition of discrimination and art. 3 of the Labor Code of the Russian Federation on the prohibition of discrimination. Read More

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January 2018

[Protection of the access to medicines right among disabled people.]

Adv Gerontol 2018;31(4):581-587

I.M.Sechenov First Moscow State Medical University, 8, Trubetskaya, str., Moscow, 119991, Russian Federation.

Disabled people remain one of the most vulnerable categories of population. Access to safe, quality and effective medicines as a key element of social well-being among people with disabilities remains of the priorities at the international agenda and national policy. The right of access to medicines among disabled people is not directly specified in any international document on the protection of the rights of persons with disabilities, which certainly affects the availability of medicines for this population in various regions of the world. Read More

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January 2018
12 Reads

[Immediate results of surgical treatment of complicated colorectal cancer in elderly and senile patients.]

Adv Gerontol 2018;31(4):574-580

I.I.Mechnikov Northwestern State Medical University, 41, Kirochnaya str., St. Petersburg, 191015, Russian Federation.

The work analyzes the results of surgical treatment of 545 elderly and senile patients with complicated forms of colon cancer. Among colon cancer complications frequently encountered acute intestinal obstruction (AIO) - 413 (75,8%), less likely to have been identified - perifocal inflammation (PPV) with abscess - 80 (14,7%), bleeding - 30 (5,5 %) and tumor perforation - 22 (4%). Operations on the colon were performed as a traditional method - 408 (74,9%) and with the use of endovideosurgical technologies - 137 (25,1%). Read More

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January 2018
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[Effect of anthropo-technogenic load on medico-social aspects of primary morbidity and disability of population.]

Adv Gerontol 2018;31(4):569-573

Rostov State Medical University, 29, Nakhichevansky lane, Rostov-on-Don, 344022, Russian Federation; e-mail:

Population aging is a global social phenomenon that affects the most important health indicators of the population. The older generation is particularly vulnerable in the current conditions of urbanization and the associated environmental situation. The comprehension of indicators of disability and morbidity of the population, the study of the factors that determine the negative processes of health damage, taking into account regional features of these processes are necessary for the planning of preventive measures. Read More

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January 2018

[Rehabilitation of hearing impaired elderly patients by means of hearing aids with frequency lowering technology.]

Adv Gerontol 2018;31(4):563-568

Audiology Center Aeron, 1а, Narvskaya str., Moscow, 125130, Russian Federation.

The objective of this study was to assess the effectiveness of rehabilitation of hearing impaired elderly patients using hearing aids with frequency lowering technology called Frequency Composition ™. 23 hearing aid users (mean age 64 years) with moderate to severe sensorineural hearing loss were tested. All participants were divided into two groups according to configuration of audiogram: 11 people with averaged slope of 27,9 dB per an octave within frequency range of 1-2 kHz (the 1st group) and 12 people with slope of 24,1 dB at 2-4 kHz (the 2nd group). Read More

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January 2018

[Dynamics and structure of primary disability in persons of retirement age when applying to the Bureau of Medical and Social Expertise of Saint Petersburg from 2006 to 2017.]

Adv Gerontol 2018;31(4):556-562

Saint-Petersburg state University, 7-9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation.

The article presents data on primary disability in elderly and able-bodied people and older than able-bodied (retirement) age as a result of the survey of citizens in the Bureau of Medical and Social Expertise of Saint Petersburg in the period 2006-2017. The features of the level, structure, dynamics and distribution by groups of disability in retirement age are reflected. There was a significant increase in the level of disability in 2007, with a progressive decline to 2011 and a gradual decline until 2017. Read More

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January 2018

[Renal dysfunction and indicators of arterial hormity in persons of elderly and senile age.]

Adv Gerontol 2018;31(4):549-555

I.K.Akhunbaev Kyrgyz State Medical Academy, 92, Akhunbaev str., Bishkek, 720020, Kyrgyzstan; e-mail:

In the presented paper had been examined parameters of arterial stiffness (stiffness index, SI m/s; reflection index, RI%; augmentation index, Alp; biological age of the vascular system, VA years; age index, AGI; alternative stiffness index, aSI; index of increase in HP=75, Aiр 75%), central arterial pressure and cystatin C content in serum. A totally were examined 98 persons (women, n=45 and men, n=53) elderly and older. A comparative analysis of arterial stiffness and its relationship with blood cystatin C in the examined groups with gender differences taken into account. Read More

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January 2018

[Clinical and experimental study of the peculiarities of cardiac activity disorders during poisoning by combustion products in persons of different age groups.]

Adv Gerontol 2018;31(4):538-548

G.A.Albrecht Federal Scientific Center of Rehabilitation of the Disabled, 50, Bestuzhevskaya str., St. Petersburg, 195067, Russian Federation.

The work is carried out to clarify the mechanisms of cardiac activity disorders and assess the severity of cardiotoxicity in acute poisoning by combustion products in the age aspect. 71 patients with severe carbon monoxide poisoning were examined. The comparison group consisted of 22 patients with acute severe opiate poisoning. Read More

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January 2018

[The influence of personal history of athletic activity on clinical course of cardiovascular diseases in former athletes.]

Adv Gerontol 2018;31(4):531-537

City multi-field hospital № 2, 5, Uchebnyi per., St. Petersburg, 194354, Russian Federation; e-mail:

In this article, the prevalence of cardiac arrhythmias and conduction disorders is evaluated in former athletes with established cardiovascular diseases compared to cohort with comparable demographic profile and prevalence of hypertension and atherosclerosis. It is shown that the group of former athletes had a higher prevalence of hemodynamically significant pauses of asystole (RR 2,94, p=0,044), SA node blocks (RR 5,51, p=0,02) and required implantation of a permanent pacemaker more frequently (RR 5,14, p=0,017). A higher level of sports performance and sports experience are associated with higher risk of atrial fibrillation, and a longer career in sports is associated with higher burden of arrhythmias and dilated atria. Read More

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January 2018
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[Ontogenetic characteristics of patients with erectile dysfunction with different types of aging.]

Adv Gerontol 2018;31(4):525-530

S.M.Kirov Military Medical Academy, 6, Acad. Lebedev str., St. Petersburg, 194044, Russian Federation; e-mail:

Age-related erectile dysfunction (ED) can be formed during ontogenesis in accordance with various mechanisms of the pathogenesis of aging in conjunction with a particular cluster of diseases. The aim of the work is to study ontogenetic features of ED patients in late ontogeny of various types of aging. 65 men over 45 with an explicit form of ED were examined. Read More

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January 2018
1 Read

[Prediction of the risk of falls and fractures using stabilometric studies in the elderly.]

Adv Gerontol 2018;31(4):517-524

I.I.Mechnikov Northwestern State Medical University, 41, Kirochnaya str., St. Petersburg, 191015, Russian Federation; е-mail:

The purpose of our study was to evaluate the parameters of the stabilogram in people over 65 years of age and to identify the parameters of the stabilometric study, which had statistically significant connections with falls and fractures.The study included 308 patients older than 65 years, living in their own homes. To perform the research tests with open (OG) and eyes closed (MO). Read More

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January 2018
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[Characteristics of periprosthetic femoral fractures after total hip replacement in elderly patients.]

Adv Gerontol 2018;31(4):510-516

Privolzhsky Research Medical University, 18, Verkhnevolzhskaya nab., Nizhny Novgorod, 603155, Russian Federation; e-mail:

In our study we analyzed 76 patients (78 hip joints) with periprosthetic femoral fractures after total hip replacement treated at Privolzhsky Federal Research Medical Centre in 2006-2016 period. We outlined specific features of periprosthetic fractures in elderly patients such as women having it more often, arise due to traumatic causes. Also elderly patients require more elaborate hardware such as cerclage wires, periprosthetic plates and additional surgical techniques such as extended trochanteric osteotomy to successfully treat periprosthetic fractures. Read More

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January 2018
1 Read

[The influence of metformin on age-related changes in the number and proliferation of dermal fibroblasts in mice.]

Adv Gerontol 2018;31(4):505-509

Chuvash State University, 15, Moskovsky pr., Cheboksary, 428015, Russian Federation; e-mail:

The goal of our work was to examine the effects of metformin on age-related changes in the number and proliferation of dermal fibroblasts in mice. The study of the dermis was carried out at five months' mice that received drinking water with metformin at concentrations 500 mg/l from two months (within 90 days). Five months' mice received drinking water without metformin and they were as a control. Read More

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January 2018

[The influence of peptides on the morphofunctional state of old rats kidneys.]

Adv Gerontol 2018;31(4):498-504

Saint-Petersburg Institute of Bioregulation and Gerontology, 3, pr. Dinamo, St. Petersburg, 197110, Russian Federation; e-mail:

More than a quarter of the elderly and senile age population suffers from kidney pathology. For this reason, a prophylaxis of kidney diseases with the safe and effective nephroprotectors is a priority of gerontology. An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research. Read More

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January 2018
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[Melatonin and man aging in the European part of the Arctic zone of the Russian Federation.]

Adv Gerontol 2018;31(4):490-497

Lovozero Central District Hospital, 2, srt. Komsomolskaya, pos. Revda, Murmansk region, 184580, Russian Federation.

The analysis of 6-sulfatoxymelatonin (6-SMT) levels in working-age men (aged 19-69) who live in the European part of the Arctic zone of the Russian Federation is presented. Their urine 6-SMT levels were similar to those of comparison group (residents of Western Siberia). The level of 6-SMT decreased with age and was the lowest in 40-49-year group. Read More

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January 2018

[Mast cells of the human pineal gland.]

Adv Gerontol 2018;31(4):484-489

Institute of Experimental Medicine, 12, Akad. Pavlova str., St. Petersburg, 197376, Russian Federation; e-mail:

The purpose of this study was to assess the possibilities of identifying mast cells using different histochemical and immunohistochemical methods and elucidating the features of their localization in the human pineal gland. The undertaken study showed that mast cells are an essential component of the human pineal gland, regardless of age. The data obtained indicate an increase in the number of mast cells in the pineal gland with age. Read More

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January 2018
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[Society for all ages: are there any prerequisites for its formation in Russia?]

Adv Gerontol 2018;31(4):473-483

Institute for Regional Economic Studies RAS, 38, Serpuhovskaya str., St. Petersburg, 190013, Russian Federation; e-mail:

Due to the implementation of the idea of the formation of a society for all ages, the present article deals with the problems of the intergenerational connections in the sphere of work and leisure. The article outlines the results of the measurement of the intergenerational relationships done by means of sociological methods. The attempt to measure the intergenerational relationships was carried out in the course of the expert poll, conducted by the authors in 2016 within the framework of the project № 16-02-00495 «Human capital of the senior generation: preservation and usage», supported by the Russian Foundation for Humanities and the Russian Foundation for Basic Research. Read More

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January 2018
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[Why and how do we age? - a single answer to the two questions.]

Authors:
A G Golubev

Adv Gerontol 2018;31(4):458-472

N.N.Petrov National Medical Research Center of Oncology, 68, Leningradskaya srt., Pesochnyi, St. Petersburg, 197758, Russian Federation; e-mail:

The chemical properties of compounds involved in metabolic processes, even the core ones, such as glycolysis and Krebs cycle, are not limited to what is realized via enzymatic reactions, because the properties include the abilities to form spontaneousely covalent bonds with other compounds, incuding those incorporated in macromolecules. The effects of the gene that codes for an enzyme, which catalizes the formation of a metabolite, which features such extra properties, may be regarded as antagonistically pleiotropic. The effects that are realized via the product of the reaction catalysed by the enzyme coded by a gene are required for current viability. Read More

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January 2018

[Social security of aging: problem statement.]

Authors:
T V Shipunova

Adv Gerontol 2018;31(3):442-448

Saint-Petersburg State University, 7-9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation; e-mail:

The article raises the question of the need to consider aging in the context of social security. The author the author shows the main stages of the humanitarization of social security, the trend of development of theoretical ideas in the direction of «human security», which develops within the framework of «enhanced security». The main object of social security of the elderly people is the safety of physical and psychological health. Read More

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January 2018

[A comprehensive research on disability caused by musculoskeletal system and connective tissue deseases among persons of working age and above in Russian Federation.]

Adv Gerontol 2018;31(3):437-441

Federal Bureau of medical and social examination, 3, Ivana Susanina str., Moscow, 127486, Russian Federation; e-mail:

As a result of conducted research on the indicators and the structure of disability caused by musculoskeletal system and connective tissue deseases, the following was found: the number of disabled people reduced by 52,9% from 2007 to 2016; the level of disability descended more than two times; in the structure of primary disability there is a prevalence of working-aged persons (52,8%), whereas their number reduced by 45% within 10 years. Persons above the working age accounted for 47,2% of the disability structure and their number fell by 60,6% within the analysed period. The highest level of disability was detected among persons above the working age, however, within last ten years it decreased more than three times. Read More

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January 2018

[Research of therapeutic physical exercise impact on functional status of elderly women.]

Adv Gerontol 2018;31(3):433-436

Astrakhan State Medical University, 121, Bakinskaya str., Astrakhan, 414000, Russian Federation; e-mail:

The article presents the results of a complex research of the impact of therapeutic exercise training on physical fitness indicators of elderly women with structural, metabolic and functional changes. 12 women aged 61-66 participated in the research, all of them underwent physical examination, risk factor assessment, electrocardiography, duplex scanning of extracranial vessels; glycemic level dynamics in the fasted state and PPG as well as fats indices, functional tests and hemodynamics parameters were assessed. The obtained results show that individual complexes of therapeutic exercises can significantly slow down the paracmastic processes and enhance the quality of life. Read More

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January 2018
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[Backward walking and its application in geriatric patients.]

Authors:
A V Klemenov

Adv Gerontol 2018;31(3):428-432

City Clinical Hospital № 30 of Nizhny Novgorod, 85а, Berezovskaja str., Nizhnij Novgorod, 603157, Russian Federation; e-mail:

The review summarizes existing information on coaching and potential treatment-and-prophylactic effect of backward walking in elderly. It provides information on the success of the backward walking to restore a stable body position and gait in persons with hemiplegia after stroke, suffering from Parkinson's disease and diabetic foot syndrome. It is noted that the tests with backward walking can be used for diagnostic purposes - to assess the severity of impaired coordination and motor skills and to predict the probability of falling in the elderly. Read More

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January 2018

[Metabolic syndrome is a risk factor for cognitive impairment among older participants of the groups of health.]

Adv Gerontol 2018;31(3):423-427

Novosibirsk Regional Gerontological Center, 3, Severnaya str., Novosibirsk, 630047, Russian Federation.

The aim of this study is to evaluate the influence of the metabolic syndrome components (MetS) on cognitive impairment (CI) in groups of health by the logistic regression with the construction of multivariate probabilistic models. This study was based on the continuous series of groups of health at the Novosibirsk Gerontological center and involved 305 aged participants. This group consisted from 31 men (10,2%) and 274 women (89,8%); the average age of men was 71,42±7,21, in women 67,45±7,62. Read More

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January 2018

[Total knee arthroplasty in senile age patients and long livers.]

Adv Gerontol 2018;31(3):416-422

S.P.Botkin Moscow City Hospital, 5, 2nd Botkinsky pr., Moscow, 125284, Russian Federation.

The analysis of results of knee arthroplasty performed in two groups of patients - 40 patients of senile age and 40 long-livers, taking into account their comorbidity was perfomed. Patients with the Charlson comorbidity index of 5-8 points, subject to hospitalization on the profile for pre-examination and inpatient treatment of aggravating somatic pathology, as preparation for a future knee replacement surgery. Results after the operation in the groups on the scale KOOS was 78±8,18 and 76±11,36, and according to WOMAC 142±4,6 and 151±4,8, respectively. Read More

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January 2018