1,713 results match your criteria Advances in gerontology = Uspekhi gerontologii[Journal]


[Theory and practice of aging upon COVID-19 pandemic.]

Adv Gerontol 2020 ;33(2):397-408

European Centre for Social Welfare Policy and Research, Berggasse 17, 1090 Vienna, Austria, e-mail:

Never before in history, aging was such a significant factor for epidemics as it is now for the current COVID-19 pandemic, which features a drastic shift of mortality towards older ages. Our analysis of data on COVID-19-related mortality in Spain, Italy, and Sweden has shown that, in the range of 30 to 90 years of age, each dependency of the logarithm of mortality upon age is linear, and all regression lines are strictly parallel to those related to the total mortality in accordance with the Gompertz law. In all cases, irrespective of the stage and place of epidemic, mortality doubling time in this age range is close to 7,5 years. Read More

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[Status and prospects of gerontology and geriatrics in the Kyrgyz Republic.]

Adv Gerontol 2020 ;33(2):391-396

I.K.Akhunbaev Kyrgyz State Medical Academy, 92 Akhunbaev str., Bishkek 720020, Kyrgyz Republic, e-mail:

The article analyzes the situation with the development of gerontology in the Kyrgyz Republic. The long-term process of the formation of the gerontological service in the country and its achievements are described in detail. The positive fact is that not only international organizations, but also the state and society itself began to pay attention to the problem of older people. Read More

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January 2020

[Benefits of androgen replacement therapy and audio-visual correction inclusion in the prevention of premature aging.]

Adv Gerontol 2020 ;33(2):385-390

S.M.Kirov Military Medical Academy, 6 str. Acad. Lebedeva, St. Petersburg 194044, Russian Federation.

There are changes in the metabolism, reproductive and nervous systems with ageing, which have a systemic and interrelated nature. The purpose of this work was to demonstrate the effectiveness of audiovisual correction and therapy with testosterone drugs in addition to the standard therapy in patients with polymorbid pathology. 89 men aged 35-55 years old with diabetes mellitus, polymorbid cardiovascular disease, obesity, anxiety and depressive disorders were examined. Read More

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January 2020

[Results of analysis of the prescriptions for elderly patients in ambulatory practice.]

Adv Gerontol 2020 ;33(2):379-384

M.K.Ammosov North-Eastern Federal University, 58 Belinskogo str., Yakutsk 677000, Russian Federation, e-mail:

A randomized retrospective analysis of medical records of patients aged 65 years and older receiving ambulatory medical care was carried out in order to assess drug prescriptions for the detection of polypharmacy and potentially dangerous and significant drug interactions. The average number of visits per patient over 65 is 11,2±8,4. Comorbidity was detected in 89,4% of patients. Read More

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January 2020

[Treatment of torpid trophic ulcers in patients of the older age group.]

Adv Gerontol 2020 ;33(2):373-378

Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova str., Novosibirsk 630060, Russian Federation, e-mail:

Chronic ulcers or non-healing ulcers are more common in the elderly (20 out of 1 000 people), whose age is closer to 80 years. The application of the principles of regenerative medicine, actively developing, in the treatment of such diseases, is based on the use of both autologous blood derivatives and autologous mononuclear cells. Objective: to evaluate the effectiveness of the use of plasma enriched with platelets in the treatment of torpid ulcers of the lower extremities in patients of the older age group. Read More

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January 2020

[Cytoflavin effect on locomotor and psychoemotional status in physiological and pathological aging.]

Adv Gerontol 2020 ;33(2):367-372

I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry, 44 Thoreza pr., St. Petersburg 194223, Russian Federation, e-mail:

Currently, the actual problem is the correction of motor, cognitive and psychoemotional disorders in physiological aging, as well as in various pathological processes that accompany aging and accelerate it. In this regard, it became necessary to search for drugs that can restore age-related disorders of the brain. The aim of the study was to evaluate the possibility of Cytoflavin as a pharmacological corrector of age-dependent disorders of the functions of the cerebral cortex during physiological and pathological, accelerated aging. Read More

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January 2020

[The influence of treatment with inactive vitamin D on intrarenal blood flow in patients with chronic obstructive pulmonary disease.]

Adv Gerontol 2020 ;33(2):360-366

Kuban State Medical University, 4 Sedina str., Krasnodar 350063, Russian Federation, e-mail:

The aim of the work was to assess the dynamics of ultrasound parameters of renal blood flow in patients with chronic obstructive pulmonary disease (COPD)and initial stages of chronic kidney disease (CKD) during treatment with inactive vitamin D. The study included 264 patients with COPD of 2-4 degrees of severity in combination with CKD of 1-2 stages: 135 patients of the main group and 129 patients of the control group. Each group was divided into 4 subgroups according to the value of FEV1 and vitamin D level. Read More

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January 2020

[Determination of cytokines in the blood serum and in the aqueous humor of the anterior camera during pseudoexfoliative syndrome and cataract.]

Adv Gerontol 2020 ;33(2):352-359

Acad. Zarifa Aliyeva National Centre of Ophthalmology, 32/15 Javadkhan str., Baku AZ 1114, Azerbaijan, e-mail:

There have been studied changes of proinflammatory cytokines, IL-1β and TNF-α, in anterior chamber aqueous humor and in blood serum before cataract surgery in 81 patients with cataract. Of these, 46 patients had verified diagnosis of pseudoexfoliative syndrome (PEХ) of varying degree of manifestation of dystrophic changes and deposits of pseudoexfoliative material (main group). In 35 patients, PES (comparison group) has not been detected. Read More

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January 2020

[Features of the picture of blood cells in elderly persons with primary open-angle glaucoma.]

Adv Gerontol 2020 ;33(2):346-351

City Hospital № 2, 5 Uchebniy per., St. Petersburg 194354, Russian Federation.

Around 1,3 billion people live worldwide with visual analyzer disorders such as glaucoma and cataract. These diseases are particularly common among the elderly. From glaucoma every year 10 million people completely lose vision, one of the factors of which is untimely diagnosis. Read More

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January 2020

[Laboratory predictors of glaucoma in patients with middle and old age - a tool to improve the quality of life (literature review).]

Adv Gerontol 2020 ;33(2):339-345

I.I.Pavlov First Saint Petersburg State Medical University, 6-8 L'vaTolstogo str., St. Petersburg 197022, Russian Federation, e-mail:

There are about 1,3 billion people worldwide with visual disorders such as cataract and glaucoma, the prevalence of which is significantly higher in elder persons. Eye diseases remain a global medical, social and economic problem, associated with both the progression of the disease up to blindness and the lack of pathogenetic therapy methods. Timely detection of pathology is secondary prevention of glaucoma. Read More

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January 2020

[Prevalence and features of geriatric syndromes treatment in old patients (clinical and epidemiological study).]

Adv Gerontol 2020 ;33(2):331-338

Smolensk State Medical University, 28 Krupskaya Str., Smolensk 214019, Russian Federation, e-mail:

We studied the prevalence of chronic non-communicable diseases (CND) in elderly and senile patients in conjunction with the syndrome of senile asthenia, the prevalence of sarcopenia depending on gender characteristics and the frequency of occurrence of the falls syndrome in patients with sarcopenia of older age groups. The features of drug therapy in outpatient practice were analyzed. The method of complex geriatric assessment was used in 528 patients divided into 3 age groups (65-74 years, 75-84 years, 85 years or more). Read More

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January 2020

[Assessment of drug therapy in psychiatric elderly patients based on the AGS Beers criteria.]

Authors:
O O Kirilochev

Adv Gerontol 2020 ;33(2):325-330

Astrakhan State Medical University, 121 Bakinskaya str., Astrakhan 414000, Russian Federation, e-mail:

The study objective was to analyze the frequency of prescription of potentially inappropriate medications (PIMs) to elderly patients treated in a psychiatric in-patient setting. This study was carried out using AGS Beers criteria, an anti-polypharmacy tool developed under the auspices of the American Geriatric Association. The study indicates a high frequency of use of PIMs from the following pharmacological groups: benzodiazepine derivatives, non-steroidal anti-inflammatory drugs (long-term use), as well as drugs with significant anticholinergic potential. Read More

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January 2020

[Predictors of neurological complications after cardiac surgical interventions in oldery patients.]

Adv Gerontol 2020 ;33(2):319-324

E.N.Meshalkin National Medical Research Center, 15 Rechkunovskaya str., Novosibirsk 630055, Russian Federation, e-mail:

To identify predictors of neurological complications in the hospital period after coronary artery bypass grafting (CABG), 92 patients with coronary heart disease aged 70 years and over were analyzed. Intraoperative monitoring of cerebral oxygenation (rSO2, %) was carried out. At the stage of induction anesthesia, the average level of rSO2 for left and right hemispheres was 64-65% without significant changes during the operation. Read More

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January 2020

[Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.]

Adv Gerontol 2020 ;33(2):313-318

I.N.Ulianov Chuvash State University, 15 Moscowski pr., Cheboksary 428015, Russian Federation, e-mail:

The aim of this work was to examine the content of arylhydrocarbon receptor nuclear translocator (ARNT) in fibroblasts of human dermis from 20 weeks of pregnancy until 85 years old, and defining of a role of ARNT in age-dependent changes in the number of fibroblasts in the dermis. ARNT, proliferating cells nuclear antigen (PCNA) were detected with indirect immunohistochemical technique. Results showed that a portion of fibroblasts with positive staining for ARNT in the dermis is decreased from 20 weeks of pregnancy to 40 years old. Read More

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January 2020

[Working ability of elderly university teachers under the combined influence of breathing exercises and peptide bioregulator «Cortexin».]

Adv Gerontol 2020 ;33(2):307-312

A.I.Herzen Russian State Pedagogical University, 48 nab. R. Moiki, St. Petersburg 191186, Russian Federation.

The two-week use of special breathing exercises in combination with the Cortexin peptide bioregulator optimizes the functional state and increases the professional performance of older teachers more effectively compared to the single use of a pharmacological preparation. The maximum effect is noted immediately after the end of the course use of special breathing exercises and the peptide bioregulator and lasts for two months. The results obtained open up prospects for the use of breathing exercises to enhance and prolong the nootropic drugs and antihypoxants antistress and geroprotective effects. Read More

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January 2020

[Neuroprotective effects of peptides.]

Adv Gerontol 2020 ;33(2):299-306

Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dinamo, St. Petersburg 197110, Russian Federation, e-mail:

Neurodegenerative diseases are a heterogeneous group of nervous system pathologies. They are found mainly in people of an older age group. The incidence of neurodegenerative diseases is continuously growing due to an increase in the average life expectancy of the population. Read More

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January 2020

The association between physical activity and self-reported health in older adults: lessons implied by lifestyle factors.

Adv Gerontol 2020 ;33(2):289-298

Africa Center for Epidemiology, P. O. Box AN 18462, Accra North, Accra, Ghana, e-mail:

Physical activity (PA) has been evidenced to be associated with self-reported health, but studies providing this evidence have failed to incorporate some relevant covariates, especially those pertinent to an African sample. This study examined the association between PA and self-reported health, with relevant lifestyle factors, comorbidities, and personal characteristics treated as covariates in this assessment. The study population was retired and working older people aged 60 years or more in Accra, Ghana. Read More

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January 2020

Prevalence and risk factors of potentially prescribing omissions in elderly and senile patients: clinical practice in Russian hospitals.

Adv Gerontol 2020 ;33(2):282-288

N.I.Pirogov Russian National Research Medical University, 1 Ostrovityanova str., Moscow 117997, Russian Federation.

A retrospective pharmacoepidemiological study (included data from medical records of 401 patients ≥65 years of age who received treatment in hospitals) was aimed to measure prevalence of potentially prescribing omissions (PPOs) among older people using Screening Tool to Alert doctors to Right Treatment 2 (START-2) criteria (2015) and to investigate associated risk factors. Statistical analysis includes methods of parametric and nonparametric statistics. We compared patients who had PPOs with those had not PPOs. Read More

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January 2020

[Alzheimer's disease: experimental and clinical researches of Chinese herbal medicine neurobiological effects (a review).]

Adv Gerontol 2020 ;33(2):273-281

V.I.Razumovsky Saratov State Medical University, 112 Bol'shaya Kazach'ya str., Saratov 410012, Russian Federation, e-mail:

The analysis of experiments and clinical data about research of neurobiological effects of chinese herbal medicine, which is used by Alzheimer`s disease treatment, was presented in given overview. The rats with injection of Aβ1-42 or Aβ25-35 peptides, or ibotenic acid, or streptozotocin as well as the natural line of mice SAMP8 with the phenotype of accelerated aging and other were used as the experimental models of Alzheimer`s disease. Various neurobiological effects of various herbal decoctions in the cells of hippocampus were demonstrated - the inhibition of amyloid β peptides aggregation, increasing of neurons quantity with normal morphology and decreasing of apoptotic cells, decreasing of inducible nitric oxide synthase (iNOS) production, decreasing of reactive expression level of RAGE and increasing reactive expression level of LRP-1, decreasing of tau protein phosphorylation at Thr231 and Ser422, inhibition of expression of GSK-3β and CDK-5, decreasing of activation and inflammation of microglia, production of 15 types of N-glycans in the cerebral cortex layers, which are absent in experimental animals. Read More

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January 2020

[Comparative analysis of unsaturated indicators fatty acids in elderly patients in initial stages of Alzheimer's disease and vascular dementia.]

Adv Gerontol 2020 ;33(2):265-272

V.M.Bekhterev National Research Medical Center for Psychiatry and Neurology, 3 Bekhterev str., St. Petersburg 192019, Russian Federation, e-mail:

A decrease in cognitive functions up to the development of dementia in the elderly is associated with a decrease in the blood level of polyunsaturated fatty acids, especially Omega-3, which occurs against the background of oxidative stress. The paper presents a comparative analysis of the spectrum of polyunsaturated fatty acids and the activity of individual components of the enzymatic antioxidant system in the blood of elderly people with impaired cognitive performance to the level of «mild cognitive decline» (MCI AD, prodromal Alzheimer's disease) or vascular etiology (MCI VaD, prodromal vascular dementia) compared with older people without signs of cognitive impairment. A decrease in the concentration of Omega-3 polyunsaturated fatty acids in the blood of both groups of the examined patients was revealed compared with the control group. Read More

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January 2020

[Cognitive aging and cognitive reserve: point of contact.]

Adv Gerontol 2020 ;33(2):256-264

Ural State Medical University, 3 Repin str., Yekaterinburg 620028, Russian Federation, e-mail:

The high risk of cognitive disorders in the elderly and senile age makes, on the one hand, to look for their causes, on the other - the possibility of prevention. In this regard, in recent years, the concept of cognitive reserve has become widespread, implying a set of quantitative parameters of the brain and its ability to maintain high functional activity in the process of aging and against the background of age-related brain pathology. The material presented in the article on the basis of the review of scientific literature highlights two main points concerning the possibility of preserving the cognitive reserve-gender and educational factors. Read More

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January 2020

[Characteristics of immune response in elderly and autoimmunity.]

Authors:
O V Moskalec

Adv Gerontol 2020 ;33(2):246-255

M.F.Vladimirsky Moscow Regional Research and Clinical Institute, 61/2 Schepkina str., Moscow 129110, Russian Federation, e-mail:

Aging is a very complex process, resulting in dysregulation of multiple systems. The most prominent changes in immunological function, termed «immunosenescence», are diminished immune response against infection, increased levels of pro-inflammatory mediators and increased risk of autoimmunity. Immunoscenescence is accompanied by the low-grade aseptic inflammation observed commonly in elderly people - «inflammaging», which is associated with a higher incidence of chronic non-infectious age-associated diseases. Read More

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January 2020

[Morbidity, mortality and reliability of accounting of patients of different age groups with liver cancer in Russia.]

Adv Gerontol 2020 ;33(2):240-245

I.I.Mechnikov North-Western State Medical University, 41 Kirochnaya str., St. Petersburg 191015, Russian Federation.

Liver cancer is a severe oncopathology. Mortality exceeds the number of primary-accounted patients in Russia on average. Every year in Russia more than eight thousand (8 810 in 2018) cases of liver cancer and more than 10 000 (10 018 in 2018) deaths from this cause are registered. Read More

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January 2020

[The first results of the analysis of the activity of the cancer service of the North-Western Federal district of the Russian Federation, conducted on the basis of the created population cancer register of the Federal district.]

Adv Gerontol 2020 ;33(2):228-239

N.N.Petrov National Medical Research Center of Oncology, 68 Leningradskaya str., Pesochny, St. Petersburg 197758, Russian Federation, e-mail:

The completely formed database of the Population Cancer Registry (PCR database) of the North-Western Federal district of the Russian Federation in February 2019 has significantly expanded the ability to objectively assess the activities of the cancer service on a more reliable basis of analytical materials. In Russia, for the first time, it was possible to conduct epidemiological studies of malignant tumors for rare tumor locations, any age groups, and calculations of patient survival rates. The PCR database has more than 1 million observations and includes all the headings and subheadings of ICD-10 for class II - codes C00-96. Read More

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January 2020

[An older woman in the local community in Russia: the neighborhood, non-government organizations and the public utilities sector.]

Adv Gerontol 2020 ;33(2):220-227

Saint-Petersburg State University, 1/3 Smolnogo str., St. Petersburg 191124, Russian Federation, e-mail:

The article probes into the development of local self-organization of retired women, actively involved in resolving housing issues at their place of residence in Saint-Petersburg. The socio-spatial approach to aging, also referred to as «aging in a place / in a community» serves the theoretical framework. This type of aging requires an active approach to the habitual environment of the elderly and their support. Read More

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January 2020

Diversity of life spans across the animal world.

Adv Gerontol 2020 ;33(2):204-219

All-Russia Research Institute for Agricultural Microbiology, 3 shosse Podbelskogo, Pushkin-8, St. Petersburg 196608, Russian Federation.

Animal world is one of the main sources of information on ageing and longevity. Several animal species are used to explore the evolution of ageing and to find the remedies to extend human longevity. However, about a third of animal phyla, and usually less, are mentioned in the relevant reviews. Read More

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January 2020

[Some problems of creating a geriatric service in the regions.]

Adv Gerontol 2020 ;33(1):189-193

Rostov State Medical University, 29 Nakhichevansky per., Rostov-on-Don 344022, Rostov Region, Russian Federation, e-mail:

The article reflects the current state of geriatric care in the Russian Federation at the stage of formation of a three-level model of geriatric service. The problems in the organization of geriatric services at the regional level, including the problem of training the appropriate profile, the negative attitude of the elderly to geriatric departments and geriatrics in General. Measures to improve the work in this direction are proposed. Read More

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January 2020

[Age-related specifics or diseases and disability caused by digestive disorders among adults in Saint-Petersburg in 2013-2017.]

Adv Gerontol 2020 ;33(1):179-188

Saint-Petersburg Chief Bureau of Medical and Social Expertise, 58 lit. A Liteiny pr., St. Petersburg 195067, Russian Federation.

The paper presents the retrospective analysis of the structure and dynamics of diseases and disability caused by digestive disorders in Saint Petersburg citizens. The paper presents the results of the comparative analysis of disability among people of active working and pension ages living in Saint Petersburg, versus Russia's average 2013-2018 data. As a result, regularities and differences in the structure and dynamics of digestive disorders in people 18 years old and older, which manifested themselves in after-surgery complications, death rate, and disability rate. Read More

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January 2020

[Factor structure of coping behavior of curious elderly people.]

Adv Gerontol 2020 ;33(1):172-178

South-Ural State Humanitarian and Pedagogical University, 69 pr. V.I.Lenina, Chelyabinsk 454080, Russian Federation, e-mail:

An increase in the share of elderly people in the total population of Russia determines the theoretical and practical significance of studies aimed at improving social adaptation and the productivity of a person's life in retirement age. The relevance of the study is due to the contradiction between the theoretical and practical significance of the problem of coping behavior of older people and its insufficient development in gerontopsychology. The purpose of the study was to establish the theoretical basis for conducting the factor analysis of coping behaviour in the elderly studying at the University and to analyse the findings. Read More

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January 2020

[Effectiveness of measures for socio-psychological rehabilitation of elderly persons in the hospital.]

Adv Gerontol 2020 ;33(1):165-171

G.A.Albrecht Federal Scientific Centre of Rehabilitation of the Disabled, 50 Bestuzhevskaya str., St. Petersburg 195067, Russian Federation, e-mail:

The aim is to study the effectiveness of social and psychological rehabilitation of elderly people at the clinic of G.A.Albrecht Federal Scientific Centre of Rehabilitation of the Disabled - the impact of rehabilitation measures on the mental sphere of rehabilitated based on the identification of statistically significant changes in the components of psychological status using the questionnaire SAN. Read More

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January 2020

[The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.]

Adv Gerontol 2020 ;33(1):159-164

Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dinamo, St. Petersburg 197110, Russian Federation.

The applying of many drugs in elderly and old people often is the reason of liver dysfunction. Thereat, the risk of liver fibroid induration, acute and chronic hepatitis increases during aging. It is the reason to find new, effective and harmless hepatoprotectors. Read More

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January 2020

Assessing the maturity of community-level built environments for older adults' active behaviors: highlights from a psychometric test.

Adv Gerontol 2020 ;33(1):153-158

Africa Center for Epidemiology, P. O. Box AN 18462, Accra North, Accra, Ghana, email:

The community development approach to healthy active aging advocates constant availability of relevant built environment factors in the community as a requirement for active behaviors. In this paper, scores from a new scale measuring these factors are interpreted to guide future assessment of active built environments in the community. Participants were 515 older adults in Accra aged 60 years or more who met some inclusion criteria. Read More

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January 2020

[Age features of bioregulatory therapy of dental diseases.]

Adv Gerontol 2020 ;33(1):137-152

S.M. Kirov Military Medical Academy, 6 Acad. Lebedeva str., Saint Petersburg 194044, Russian Federation.

The article presents data on the use of peptide bioregulators of cell homeostasis and the protective functions of the body in various dental diseases and pathology of organs and tissues of the maxillofacial region. Issues related to the immunopharmacological effect and clinical use of natural and synthetic peptide thymomimetics (thymalin, thymogen, vilon, epithalamin, cortexin) and peptide bioregulators from cartilaginous (sigumir, chondrolux) and other tissues in case of trauma, as well as inflammatory, inflammatory and other pathological processes of tissues of the oral cavity and maxillofacial region. Particular attention is paid to their use in the complex treatment of dental diseases in the elderly. Read More

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January 2020

[Possibilities for predicting of cardiac arrhythmias and conductivity disorders in former athletes.]

Adv Gerontol 2020 ;33(1):131-136

Saint-Petersburg State University, 7/9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation, e-mail:

In order to analyze the relationship between the athletic qualification and syndrome of cardiac rhythm and conductivity disturbances in former athletes, a retrospective analysis of medical records of 39 male former athletes with cardiovascular complaints (mean age 61,6±11,3 years, mean duration of career in sports 23,9±17,3 years, mean duration of post-athletic period 20,1±9,9 years) was carried out. The patients were screened for cardiac arrhythmias and underwent echocardiography. The overall prevalence of sustained paroxysms of atrial fibrillation was 42%, increasing with the athletic qualification. Read More

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January 2020

[Study of the most significant for the correction components of the functional condition of elderly hockey players.]

Adv Gerontol 2020 ;33(1):127-130

I.I.Mechnikov North-West State Medical University, 41 Kirochnaya str., St. Petersburg 191015, Russian Federation.

Presents the results of a dynamic integrated study of the vegetative, metabolic and psycho-physiological components of the functional state of elderly hockey players before and after participating in competitions. The study involved 42 male hockey players aged 55-64 years. It has been established that the indicators of the vegetative regulation of cardiac activity are the most stable component of the functional state in the group of elderly athletes. Read More

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January 2020

[Sarcopenia as the reason of hypodiagnostics of chronic kidney disease in patients with chronic heart failure.]

Adv Gerontol 2020 ;33(1):121-126

S.M.Kirov Military Medical Academy, 6 Acad. Lebedev str., St. Petersburg 194044, Russian Federation, e-mail:

The purpose of the research is comparison of glomerular filtration rate calculated on the basis of serum concentrations of creatinine and cystatin C in patients with chronic heart failure and sarcopenia. In this research 86 patients with chronic heart failure and sarcopenia aged 60 to 92 years (mean age 75±7 years) were examined. GFR calculation was determined using formulas based on creatinine (CKD-EPIC), cystatin C (CKD-EPICys) in blood and both markers (CKD-EPICr-Cys). Read More

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January 2020

[Features of chronic kidney disease in elderly patients.]

Authors:
O N Kurochkina

Adv Gerontol 2020 ;33(1):113-120

Pitirim Sorokin Syktyvkar State University, 55 Oktyabrsky pr., Syktyvkar 557001, Komi Republic, Russian Federation, e-mail:

The purpose of the work is to study the characteristics of the course of chronic kidney disease in elderly patients based on the analysis of the register of chronic kidney disease (CKD) for 2015-2018. in the Department of Nephrology, the Komi Republican Clinical Hospital. There are 484 patients in the register, of whom 231 are men (47,7%), 253 women (52,3%). Read More

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January 2020

[Determination of cytokines and adhesion molecules in elderly and senile patients with aortic valve calcification.]

Adv Gerontol 2020 ;33(1):107-112

S.M.Kirov Military Medical Academy, 6 Acad. Lebedeva str., St. Petersburg 194044, Russian Federation, e-mail:

A laboratory study of the cytokine profile and the content of the intercellular adhesion molecules was performed in 38 patients with initial signs of aortic hemilunus calcification. It has been determined that the content of IL-6 and IL-8 had significantly higher values compared with the control group, which indicates the direct role of nonspecific chronic inflammation in the development of calcifying aortic valve damage. A significantly lower content of sE-selectin was also identified, which may indicate the absence of activation of adhesion molecules at the initial stage of aortic valve calcification. Read More

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January 2020

[Anticoagulant therapy in cancer patients with atrial fibrillation. Considering age factor.]

Adv Gerontol 2020 ;33(1):99-106

Saint-Petersburg Clinical Hospital RAS, 72 Toreza pr., St. Petersburg 194017, Russian Federation, e-mail:

The current issue of the choice of anticoagulant therapy of atrial fibrillation (AF) in cancer patients is considered. It is noted that the difficulty of choosing an anticoagulant in malignancies is largely determined by age-related factors, such as comorbid cardiovascular diseases, liver and kidney dysfunction, metabolic disorders common for in elderly patients. Current data on the risk assessment of hemorrhagic and thromboembolic complications of AF in cancer patients in the aspect of age presented. Read More

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January 2020

[Personified monitoring of acute coronary syndrome and its outcomes in elderly patients. Angina. Heart failure (overview).]

Authors:
A S Pushkin

Adv Gerontol 2020 ;33(1):92-98

Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo pr., St. Petersburg 197110, Russian Federation, e-mail:

Review is about current information on the features of heart failure and angina diagnosis and monitoring in elderly and senile patients. One of the main problem in patients over 65 years is comorbidity, which requires corrective action in the risk stratification and prediction of clinical outcomes. The priority of non-invasive diagnostic tests is noted. Read More

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January 2020

[Optimization of the invasive strategy for acute coronary syndrome in patients of the older age group.]

Adv Gerontol 2020 ;33(1):87-91

S.M.Kirov Military Medical Academy, 6 Acad. Lebedev str., St. Petersburg 194044, Russian Federation.

A study is presented on the effectiveness and safety of various anticoagulants used in patients of an older age group with acute coronary syndrome during percutaneous coronary interventions. Bivalirudin was shown to be highly effective in comparison with unfractionated heparin and monafram in relation to the amount of bleeding that occurs in the postoperative period and adverse cardiovascular complications. Read More

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January 2020

[The information content and predictive value of cardiac markers in myocardial infarction in the elderly.]

Adv Gerontol 2020 ;33(1):82-86

Scientific Clinical Center JSC «Russian Railways», 84, build. 3 Volokolamskoye shosse, Moscow 101000, Russian Federation.

Myocardial infarction in old age is the leading pathology and cause of deaths. The aim of the study was to evaluate the prognostic significance and informative value of cardiac markers of blood in elderly patients with myocardial infarction. The study of cardiac markers in 107 patients with myocardial infarction at the age of 65-75 years and in 83 patients with myocardial infarction at the age of 50-60 years was carried out by immunochromatographic, bioluminescent methods and by electrophoresis on cellulose acetate, followed by the calculation of informativeness and prognostic coefficients. Read More

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January 2020

[Features of autonomic regulation of the cardiovascular system in human late ontogenesis.]

Adv Gerontol 2020 ;33(1):74-81

I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, 44 Toreza pr., St. Petersburg 194223, Russian Federation, e-mail:

Using the method of arterial piezopulsometry, statistical and spectral analyzes of variable parameters (VmaxPP and TNN) of pulse waves of blood pressure in patients aged 18 to 85 years were performed. The individual characteristics of the autonomous (vegetative and neuroendocrine) regulation of the muscular effectors (ME) of the cardiovascular system (CVS) in an elderly man (75 years old) and a young woman (20 years old) were estimated with high accuracy. These data, as well as the results of a comparative study of patients of different ages, made it possible to identify a certain pattern of directed change in the sympathoadrenal regulation of ME CVS in human ontogenesis. Read More

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January 2020

[The role of comprehensive geriatric assessment in the treatment of cancer patients in elderly and senile age.]

Adv Gerontol 2020 ;33(1):65-73

N.N.Petrov National Medical Research Centre of Oncology, 68 Leningradskaya str., Pesochny, St. Petersburg 197758, Russian Federation, e-mail:

Modern approaches to the organization of diagnosis and treatment of elderly and senile patients with malignant tumors allow to maintain the necessary level of health, improve the quality of life and increase life expectancy. Assessment of geriatric status in Oncology allows: to predict complications during the complex treatment, including drug treatment; to modify treatment to reduce the risk factors of adverse outcomes; to select patients for specialized treatment using standard schemes. So, timely assessment of geriatric syndromes and their correction can expand the indications for specialized treatment of elderly and senile patients. Read More

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January 2020

[Timing and methodology for the integrated geriatric assessment of the city geriatric center.]

Adv Gerontol 2020 ;33(1):62-64

I.I.Mechnikov North-Western State Medical University, 41 Kirochnaya str., St. Petersburg 191015, Russian Federation, e-mail:

A study was carried out on the timing of the complex geriatric assessment by nursing staff in the geriatric center of Saint Petersburg. 65 patients (women) were examined. It is concluded that the complex geriatric assessment can and should be carried out by the nursing staff, the duration of the complex geriatric assessment depends on the actual age, and the expression of frailty, the average time spent on it varies from 1 to 2 hours, the complex geriatric assessment should be carried out within 1 to 3 days. Read More

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January 2020

[Structural and functional changes of endothelium of heart's vessels of old rats according to immunistochemical studies.]

Adv Gerontol 2020 ;33(1):55-61

Institute of Experimental Medicine, 12 Akad. Pavlova str., St. Petersburg 197376, Russian Federation.

The aim of the work is to investigate the morphofunctional changes of the vascular endothelium in different parts of the heart of aging rats using immunohistochemical detection of Willebrand factor. Reactive, dystrophic and pathological changes of endotheliocytes in different parts of the heart of old (18-23 months) rats were first identified using an immunohistochemical marker vWF. They are most expressed in the endothelium of the arterial vessels of the aortic root, coronary arteries of the epicardium, and myocardial capillaries. Read More

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January 2020

[Short peptides: regulation of skin function during aging.]

Adv Gerontol 2020 ;33(1):46-54

Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dinamo, St. Petersburg 197110, Russian Federation, e-mail:

Short peptides are applied for supporting skin function during ageing, because they can permeate the intact stratum corneum of the epidermis and affect the cells of the dermis. Short peptides are part of natural metabolism of cells and many of them have geroprotective properties. In the review we are considering the base sorts of peptides that are used for normalized skin fibroblasts function: matrikines, carnosine, collagen peptides, cytokine and growth factor analogs, defensins, immunoprotective peptides and polyfunctional peptides. Read More

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January 2020

[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.]

Adv Gerontol 2020 ;33(1):40-45

I.N.Ulianov Chuvash State University, 15 Moscowski pr., Cheboksary 428015, Russian Federation, e-mail:

The aim of this work was to examine the content of heat shock protein 90 (HSP90) in fibroblasts of human dermis from the development until deep aging (from 20 weeks of pregnancy until 85 years old), and defining of a role of HSP90 in age-dependent changes in the number of fibroblasts in the dermis. HSP90, proliferating cells nuclear antigen (PCNA) were detected with indirect immunohistochemical technique. Results showed that a portion of fibroblasts with positive staining for HSP90 in the dermis is not changed from 20 weeks of development to 20 years old. Read More

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January 2020

[FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.]

Adv Gerontol 2020 ;33(1):34-39

N.N.Petrov National Medical Research Center of Oncology, 68 Leningradskaya str., Pesochny, St. Petersburg 197758, Russian Federation, e-mail:

The cell resistance to apoptosis can be related to the activity of cytokine-dependent signaling. So, the aim of the work is to investigate the mechanisms of cytokine-dependent FAS/TNF-mediated regulation of apoptosis of neurosecretory cells in the physiological and pathological (overexpression of the oncogene HER-2/Neu) aging. HER2/Neu transgenic accelerated aged mice of different ages and wild type FVB/N were examined. Read More

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January 2020

[Natural age-related cognitive impairments: overview of recent investigations in non-human primates.]

Adv Gerontol 2020 ;33(1):23-33

I.P.Pavlov Institute of Physiology, RAS, 6 Makarov emb., St. Petersburg 199034, Russian Federation, e-mail:

Human aging is followed by the weakening of cognitive functions of the brain. The relevance of the study of this process as well as the search for ways of its medical correction increases due to the rise of the middle life span in developed countries. Non-human primates are recognized as the most appropriate biological model for the experimental study of natural cognitive aging mechanisms. Read More

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January 2020