Association Between Vitamin D and Carboxy-Terminal Cross-Linked Telopeptide of Type I Collagen in Children During Growth Hormone Replacement Therapy.
- Ewelina Witkowska-Sędek,
- Anna Stelmaszczyk-Emmel,
- Anna Kucharska,
- Urszula Demkow,
- Beata Pyrżak
Adv Exp Med Biol 2017 Sep 22. Epub 2017 Sep 22.
Department of Paediatrics and Endocrinology, Medical University of Warsaw, 63A Żwirki and Wigury Street, 02-091, Warsaw, Poland.
Growth hormone and insulin-like growth factor-1 (IGF-1) play a crucial role in the regulation of bone turnover. Adequate vitamin D status supports proper bone remodeling, leading to normal longitudinal bone growth and normal peak bone mass. The aim of this study was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and carboxy-terminal cross-linked telopeptide of type I collagen (ICTP) in children and adolescents with growth hormone deficiency at baseline and during recombinant human growth hormone (rhGH) replacement therapy. Read More