589 results match your criteria Advances in clinical chemistry[Journal]


Preface.

Adv Clin Chem 2019;89:xi

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http://dx.doi.org/10.1016/S0065-2423(19)30014-9DOI Listing
January 2019

Clinical implications of fetuin-A.

Adv Clin Chem 2019;89:79-130. Epub 2019 Feb 8.

Department of Internal Medicine I, Divisions of Nephrology and Endocrinology, Paracelsus Medical University, Salzburg, Austria.

Fetuin-A, also termed alpha2-Heremans-Schmid glycoprotein, is a 46kDa hepatocyte derived protein (hepatokine) and serves multifaceted functions. Read More

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February 2019

New biomarkers in endometriosis.

Adv Clin Chem 2019;89:59-77

Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

Endometriosis is a benign gynecological disorder which presents significant challenges in terms of diagnosis and management. Despite decades of research, there are no sufficiently sensitive and specific signs and symptoms nor blood tests for the clinical confirmation of endometriosis, which hampers prompt diagnosis and treatment. The huge majority of potential biomarkers has been discarded in research stage and very few have been translated to clinical practice. Read More

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January 2019
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The chemical and laboratory investigation of hemolysis.

Adv Clin Chem 2019;89:215-258

Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, United States; Pathology & Laboratory Medicine Service, VA Connecticut Healthcare System, West Haven, CT, United States. Electronic address:

The abnormal breakdown of circulating red blood cells (RBCs), also known as hemolysis, is a significant clinical issue that can present as a primary disorder or arise secondary to another disease process. The evaluation for pathologic hemolysis (and the establishment of a hemolytic disorder) is heavily dependent on assays performed and overseen by the divisions of Hematology, Blood Bank/Transfusion Medicine, Clinical Chemistry, and Immunology in the clinical laboratory. Because of the wide variety of assays used across the spectrum of clinical pathology and potential pitfalls/limitations associated with this testing, the decision of which assay to choose and, perhaps more importantly, how to interpret results, can both be quite challenging. Read More

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January 2019

Glycosylation markers in cancer.

Adv Clin Chem 2019;89:189-213. Epub 2019 Jan 17.

Department of Biochemistry, Research Group for Glycosciences and Glycotechnology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. Electronic address:

Alteration of glycosylation, a hallmark of cancer, results in the production of tumor-associated glycans or glycoproteins. These molecules are subsequently secreted or membrane-shed into the blood stream and thus serve as tumor-associated markers. Increased glycosylation in cancer is triggered by overexpression of glycoproteins that carry certain specific glycans, increase or decrease of nucleotide sugar donors and altered expression of glycosyltransferase and glycosidase enzymes. Read More

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January 2019

Implementing circulating tumor DNA analysis in a clinical laboratory: A user manual.

Adv Clin Chem 2019;89:131-188. Epub 2019 Jan 28.

Service of Medical Genetics, Diagnostics Department, Geneva University Hospital, Geneva, Switzerland. Electronic address:

Liquid biopsy, the analysis of cell-free circulating tumor DNA (ctDNA), is becoming one of the most promising tools in oncology. It has already shown its usefulness in selecting and modulating therapy via remote analysis of the tumor genome and holds important promises in cancer therapy and management, such as assessing the success of key therapeutic steps, monitoring residual disease, early detection of relapses, and establishing prognosis. Yet, ctDNA analysis is technically challenging and its implementation in the laboratory raises multiple strategic and practical issues. Read More

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January 2019
1 Read

Laboratory assessment of multiple myeloma.

Adv Clin Chem 2019;89:1-58. Epub 2019 Jan 22.

Division of Haematology, The Ottawa Hospital General Campus, Ottawa, ON, Canada.

Laboratory testing plays an essential role in the diagnosis and management of patients with multiple myeloma. A variety of chemistry and molecular assays are routinely used to monitor patient progress, response to treatment and relapse. Here, we have reviewed current literature and core guidelines on the details of laboratory testing in myeloma-related investigations. Read More

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January 2019
2 Reads

Preface.

Adv Clin Chem 2019;88:ix

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http://dx.doi.org/10.1016/S0065-2423(18)30086-6DOI Listing
January 2019

Novel glomerular filtration markers.

Adv Clin Chem 2019;88:91-119. Epub 2018 Nov 16.

Department of Chemical Pathology, Faculty of Health Sciences, University of Kwa-Zulu Natal and National Health Laboratory Services, Durban, South Africa.

Chronic kidney disease is currently assessed by estimated glomerular filtration rate, a mathematical construct based on creatinine or creatinine and cystatin concentration. Creatinine-based equations have improved with standardization efforts and the Modification of Diet in Renal Disease Study (MDRD) and CKD-Epidemiology Collaboration Study (CKD-EPI). Because the measurement of creatinine is subject to interference from non-GFR determinants, alternative markers have long been sought. Read More

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November 2018
7 Reads

Probing the endogenous peptidomes of cancer for biomarkers: A new endeavor.

Adv Clin Chem 2019;88:67-89. Epub 2018 Dec 27.

UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

The life span of cancer patients can be prolonged with appropriate therapies if detected early. Mass screening for early detection of cancer, however, requires sensitive and specific biomarkers obtainable from body fluids such as blood or urine. To date, most biomarker discovery programs focus on the proteome rather than the endogenous peptidome. Read More

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December 2018
9 Reads
2.646 Impact Factor

Extracellular vesicle-associated MMPs: A modulator of the tissue microenvironment.

Authors:
Masayuki Shimoda

Adv Clin Chem 2019;88:35-66. Epub 2018 Nov 23.

Department of Pathology, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Extracellular vesicles (EVs) are small particles that mediate intercellular communications in local and distant microenvironments. Due to their ability to carry bioactive materials such as proteins, nucleic acids, and lipids, and to transfer their cargo into target cells, EVs are thought to be crucial mediators under pathological and physiological conditions. Recent investigations of their protein profiles have revealed the presence of metalloproteinases such as matrix metalloproteinases (MMPs) in EVs from various cell types and body fluids. Read More

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November 2018

Emicizumab (ACE910): Clinical background and laboratory assessment of hemophilia A.

Adv Clin Chem 2019;88:151-167. Epub 2018 Nov 16.

Department of Haematology, Sydney Centres fosr Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Westmead, NSW, Australia.

Congenital hemophilia A, a relatively common and sometimes life-threatening bleeding disorder, is caused by inherited deficiency of clotting factor (F) VIII. The adoption of an appropriate medical and environmental prophylaxis is critical for long-term management of hemophilia because it will considerably reduce the number of both mild and severe bleeding episodes. Among the many therapeutic options that have become available over the past decades, ACE910 (also known as emicizumab) is a bispecific immunoglobulin G antibody characterized by its unique ability to bind FIX or FIXa on one arm and FX on the other, thus abrogating FVIII activity in vivo. Read More

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November 2018
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Clinical metabolomics of exhaled breath condensate in chronic respiratory diseases.

Adv Clin Chem 2019;88:121-149. Epub 2018 Nov 22.

Institute of Biomolecular Chemistry, National Research Council, Naples, Italy. Electronic address:

Chronic respiratory diseases (CRDs) are complex multifactorial disorders involving the airways and other lung structures. The development of reliable markers for an early and accurate diagnosis, including disease phenotype, and prediction of the response and/or adherence to treatment prescribed are essential points for the correct management of CRDs. Beside the traditional techniques to detect biomarkers, "omics" sciences have stimulated interest in clinical field as they could potentially improve the study of disease phenotype. Read More

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November 2018
7 Reads

Anti-angiogenic isoform of vascular endothelial growth factor-A in cardiovascular and renal disease.

Adv Clin Chem 2019;88:1-33. Epub 2018 Nov 16.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Accumulating evidence suggests that pathologic interactions between the heart and the kidney can contribute to the progressive dysfunction of both organs. Recently, there has been an increase in the prevalence of cardiovascular disease (CVD) and chronic kidney disease (CKD) due to increasing obesity rates. It has been reported that obesity causes various heart and renal disorders and appears to accelerate their progression. Read More

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November 2018
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Preface.

Adv Clin Chem 2018;87:xiii-xiv

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http://dx.doi.org/10.1016/S0065-2423(18)30065-9DOI Listing
January 2018
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Serum Ethanolamine Plasmalogen and Urine Myo-Inositol as Cognitive Decline Markers.

Adv Clin Chem 2018;87:69-111. Epub 2018 Aug 30.

Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Recent studies have suggested that metabolic disorders, particularly type 2 diabetes mellitus (T2DM), and dementia, including Alzheimer's disease (AD), were linked at the clinical and molecular levels. Brain insulin deficiency and resistance may be key events in AD pathology mechanistically linking AD to T2DM. Ethanolamine plasmalogens (PlsEtns) are abundant in the brain and play essential roles in neuronal function and myelin formation. Read More

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August 2018
20 Reads

Protein Carbamylation in Chronic Kidney Disease and Dialysis.

Adv Clin Chem 2018;87:37-67. Epub 2018 Aug 23.

Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Protein carbamylation is a nonenzymatic posttranslational protein modification that can be driven, in part, by exposure to urea's dissociation product, cyanate. In humans, when kidney function is impaired and urea accumulates, systemic protein carbamylation levels increase. Additional mediators of protein carbamylation have been identified including inflammation, diet, smoking, circulating free amino acid levels, and environmental exposures. Read More

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August 2018
18 Reads

Fecal Calprotectin.

Adv Clin Chem 2018;87:161-190. Epub 2018 Oct 1.

MRCP Consultant Gastroenterologist, Barts Health NHS Trust, London, United Kingdom.

Calprotectin is a 36kDa member of the S100 family of proteins. It is derived predominantly from neutrophils and has direct antimicrobial effects and a role within the innate immune response. Calprotectin is found in various body fluids in proportion to the degree of any existing inflammation and its concentration in feces is about six times that of plasma. Read More

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October 2018
9 Reads

Glutathione as a Marker for Human Disease.

Adv Clin Chem 2018;87:141-159. Epub 2018 Aug 23.

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, United States; Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, United States.

Glutathione (GSH), often referred to as "the master antioxidant," participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be overstated. GSH deficiency causes cellular risk for oxidative damage and thus as expected, GSH imbalance is observed in a wide range of pathological conditions including tuberculosis (TB), HIV, diabetes, cancer, and aging. Consequently, it is not surprising that GSH has attracted the attention of biological researchers and pharmacologists alike as a possible target for medical intervention. Read More

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August 2018
13 Reads
2.650 Impact Factor

Free Circulating miRNAs Measurement in Clinical Settings: The Still Unsolved Issue of the Normalization.

Adv Clin Chem 2018;87:113-139. Epub 2018 Aug 23.

Laboratory of Experimental Biochemistry & Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.

Circulating molecules that are released into the circulation in response to specific stimuli are considered potential biomarkers for physiological or pathological processes. Their effective usefulness as biomarkers resides in their stability and high availability in all the biological fluids, combined with the limited invasiveness of intervention. Among the circulating molecules, miRNAs represent a novel class of biomarkers as they possess all the required characteristics such as sensitivity, predictivity, specificity, robustness, translatability, and noninvasiveness. Read More

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Long Noncoding RNAs: Advances in Lipid Metabolism.

Adv Clin Chem 2018;87:1-36. Epub 2018 Aug 23.

Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, China.

Long noncoding RNAs (lncRNAs) are an important group of pervasive noncoding RNAs (>200nt) proposed to be crucial regulators of numerous physiological and pathological processes. Through interactions with RNA, chromatin, and protein, lncRNAs modulate mRNA stability, chromatin structure, and the function of proteins (including transcription factors). In addition, to their well-known roles in the modulation of cell growth, apoptosis, neurological disease progression and cancer metastasis, these large molecules have also been identified as likely mediators of lipid metabolism. Read More

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August 2018
32 Reads

Preface.

Adv Clin Chem 2018;86:ix-x

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http://dx.doi.org/10.1016/S0065-2423(18)30049-0DOI Listing
January 2018

New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men.

Adv Clin Chem 2018;86:71-125. Epub 2018 Aug 18.

Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of California at Davis, Davis, CA, United States.

Androgens can have variable effects on men and women. Women may be evaluated for androgen excess for several reasons. Typically, young premenopausal women present with clinical symptoms of hirsutism, alopecia, irregular menses, and/or infertility. Read More

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August 2018
23 Reads

Role of Salivary Biomarkers in Oral Cancer Detection.

Adv Clin Chem 2018;86:23-70. Epub 2018 Jul 23.

Materials Science and Engineering Department, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom.

Oral cancers are the sixth most frequent cancer with a high mortality rate. Oral squamous cell carcinoma accounts for more than 90% of all oral cancers. Standard methods used to detect oral cancers remain comprehensive clinical examination, expensive biochemical investigations, and invasive biopsy. Read More

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July 2018
25 Reads
2.650 Impact Factor

The Proteome of Cataract Markers: Focus on Crystallins.

Adv Clin Chem 2018;86:179-210. Epub 2018 Jul 13.

Eye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Key Laboratory of Myopia, Ministry of Health PR China, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai Medical College, Fudan University, Shanghai, China.

Cataract is a major cause of blindness worldwide. It is characterized by lens opacification and is accompanied by extensive posttranslational modifications (PTMs) in various proteins. PTMs play an essential role in lens opacification. Read More

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July 2018
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Selenium in Complicated Pregnancy. A Review.

Adv Clin Chem 2018;86:157-178. Epub 2018 Jul 31.

Department of Cosmetology and Physiotherapy, Higher School of Health Sciences, Bydgoszcz, Poland. Electronic address:

Selenium (Se) is an essential trace element of significant importance in human health. Diet is the major source of Se, and intake of this element depends on its concentration in food sources as well as the amount of those sources consumed. Unfortunately, daily dietary intake of Se in most European countries is generally low, ∼30-40μg/day, compared with the recommended dietary allowance, ∼55 and 70μg/day for adult females and males, respectively. Read More

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July 2018
49 Reads

Advances in PCOS Pathogenesis and Progression-Mitochondrial Mutations and Dysfunction.

Authors:
Ioana R Ilie

Adv Clin Chem 2018;86:127-155. Epub 2018 Jun 9.

Department of Endocrinology, University of Medicine and Pharmacy 'Iuliu-Hatieganu', Cluj-Napoca, Romania; E-mail:

Polycystic ovary syndrome (PCOS) is a common female endocrine disorder, which still remains largely unsolved in terms of etiology and pathogenesis despite important advances in our understanding of its genetic, epigenetic, or environmental factor implications. It is a heterogeneous disease, frequently associated with insulin resistance, chronic inflammation, and oxidative stress and probably accompanied with subclinical cardiovascular disease (CVD) and some malignant lesions as well, such as endometrial cancer. Discrepancies in the clinical phenotype and progression of PCOS exist between different population groups, which nuclear genetic studies have so far failed to explain. Read More

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June 2018
7 Reads

Tissue and Blood Biomarkers in Lung Cancer: A Review.

Adv Clin Chem 2018;86:1-21. Epub 2018 May 30.

Princess Alexandra Hospital, Translational Research Institute and Queensland University of Technology, Brisbane, QLD, Australia.

Lung cancer is the most common cause of cancer-related death, worldwide. Historically, lung cancer has been divided into two main histological types: small cell and nonsmall cell (NSC) type with the latter being subdivided into adenocarcinoma, squamous cell type, and large cell type. The treatment of the NSC lung cancer (NSCLC), especially the adenocarcinoma subtype, has been transformed in the last decade by the availability of predictive biomarkers for molecularly targeted therapies. Read More

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May 2018
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Preface.

Adv Clin Chem 2018;85:xi-xii

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http://dx.doi.org/10.1016/S0065-2423(18)30026-XDOI Listing
January 2018
1 Read

Proteomics for Biomarker Identification and Clinical Application in Kidney Disease.

Adv Clin Chem 2018;85:91-113. Epub 2018 Mar 6.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, Xi'an, China. Electronic address:

Treatment effectiveness for kidney disease is limited by lack of accuracy, sensitivity, specificity of diagnostic, prognostic, and therapeutic biomarkers. The gold standard test renal biopsy along with serum creatinine and proteinuria is often necessary to establish a diagnosis, particularly in glomerular disease. Proteomics has become a powerful tool for novel biomarker discovery in kidney disease. Read More

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March 2018
2 Reads
2.650 Impact Factor

Obesity, Thrombotic Risk, and Inflammation in Cancer.

Adv Clin Chem 2018;85:71-89. Epub 2018 Mar 6.

Unidad de Investigación Biomédica 02 (UIEC), UMAE HE CMNO IMSS, Guadalajara, Jalisco, Mexico; Programa Internacional de Medicina, Universidad Autónoma de Guadalajara, Zapopan, Jalisco, Mexico; División de Medicina Interna, Servicio de Inmunología y Reumatología, Hospital General de Occidente, Secretaria de Salud Jalisco, Zapopan, Jalisco, Mexico. Electronic address:

Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i. Read More

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March 2018
2 Reads

Metabolomics and Lipidomics of Ischemic Stroke.

Authors:
Anthony Au

Adv Clin Chem 2018;85:31-69. Epub 2018 Mar 8.

Institute of Bioproduct Development, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia. Electronic address:

Ischemic stroke is a sudden loss of brain function due to the reduction of blood flow. Brain tissues cease to function with subsequent activation of the ischemic cascade. Metabolomics and lipidomics are modern disciplines that characterize the metabolites and lipid components of a biological system, respectively. Read More

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March 2018
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Uncertainty in Measurement: Procedures for Determining Uncertainty With Application to Clinical Laboratory Calculations.

Adv Clin Chem 2018;85:149-211. Epub 2018 Apr 5.

Discipline of Laboratory Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.

In Part II of this review we consider the very common case of multiple inputs to a measurement process. We derive, using only elementary steps and the basic mathematics covered in Part I, the formula for the propagation of uncertainties from the inputs to the output. The Gaussian density distribution is briefly explained, since an understanding of this distribution is needed for the determination of so-called expanded uncertainties at the end of a measurement process. Read More

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Adiponectin and Its Isoforms in Pathophysiology.

Adv Clin Chem 2018;85:115-147. Epub 2018 Mar 14.

VU University Medical Center, Amsterdam, The Netherlands; VU University, Amsterdam, The Netherlands.

Adiponectin circulates in blood in multiple isoforms. High molecular weight (HMW) adiponectin is thought to be most biologically active and promotes glucose uptake, insulin sensitivity, and fatty acid oxidation. In obesity, adiponectin isoform formation is disrupted, leading to an inverse association between metabolic disease and HMW and total adiponectin. Read More

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March 2018
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Standardization of BNP and NT-proBNP Immunoassays in Light of the Diverse and Complex Nature of Circulating BNP-Related Peptides.

Adv Clin Chem 2018;85:1-30. Epub 2018 Mar 3.

School of Biology, Moscow State University, Moscow, Russia.

Brain natriuretic peptide (BNP) and the N-terminal fragment of the BNP precursor (NT-proBNP) are widely used as heart failure (HF) biomarkers. Since the discovery of BNP in 1988, much effort has been allocated to the precise detection of BNP and NT-proBNP levels for reliable HF diagnostics. As a result, measurements of these biomarkers are globally accepted and used in clinical practice for the diagnosis of acute and chronic HF, risk stratification, and monitoring response to therapy. Read More

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March 2018
3 Reads

Preface.

Adv Clin Chem 2018;84:ix

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January 2018

Metabolomics of Major Depressive Disorder and Bipolar Disorder: Overview and Future Perspective.

Authors:
Kenji Hashimoto

Adv Clin Chem 2018;84:81-99. Epub 2018 Feb 1.

Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

Major depressive disorder (MDD) and bipolar disorder (BD) are the most common mood disorders. They are etiologically related, but clinically distinct psychiatric illnesses. Their shared clinical features result in high rates of misdiagnosis due to a lack of biomarkers that allow their differentiation. Read More

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February 2018
1 Citation
2.650 Impact Factor

Inflammatory Response During Myocardial Infarction.

Adv Clin Chem 2018;84:39-79. Epub 2018 Feb 2.

Laboratory of Atherosclerosis and Vascular Biology, State University of Campinas, Campinas, Brazil. Electronic address:

The occlusion of a coronary artery by a thrombus generated on a ruptured atherosclerotic plaque has been pursued in the last decades as a determining event for the clinical outcome after myocardial infarction (MI). Yet, MI causes a cell death wave front, which triggers an inflammatory response to clear cellular debris, and which in excess can double the myocardial lesion and influence the clinical prognosis in the short and long term. Accordingly, proper, timely regulated inflammatory response has now been considered a second pivotal player in cardiac recovery after MI justifying the search for pharmacological strategies to modulate inflammatory effectors. Read More

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February 2018
3 Reads

Distribution of Fatty Acids and Lipids During Pregnancy.

Adv Clin Chem 2018;84:209-239. Epub 2018 Feb 1.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.

Maternal fatty acid and lipid metabolism undergoes changes during pregnancy to facilitate fetal growth and development. Different types of fatty acids have different roles in maintaining a successful pregnancy and they are incorporated into different forms of lipids for the purpose of storage and transport. This chapter aims to provide an understanding of the distribution and metabolism of fatty acids and lipids in the maternal, placental, and fetal compartments. Read More

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February 2018
3 Reads

Uncertainty in Measurement: Procedures for Determining Uncertainty With Application to Clinical Laboratory Calculations.

Adv Clin Chem 2018;84:125-207. Epub 2018 Feb 19.

Discipline of Laboratory Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.

The "Guide to the Expression of Uncertainty in Measurement" (GUM) is the foundational document of metrology. Its recommendations apply to all areas of metrology including metrology associated with the biomedical sciences. When the output of a measurement process depends on the measurement of several inputs through a measurement equation or functional relationship, the propagation of uncertainties in the inputs to the uncertainty in the output demands a level of understanding of the differential calculus. Read More

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February 2018
1 Read

Blood Glucose Determination: Effect of Tube Additives.

Adv Clin Chem 2018;84:101-123. Epub 2018 Feb 1.

University Hospital Sveti Duh, Zagreb, Croatia.

The measurement of fasting plasma glucose may be biased by a time-dependent decrease of glucose in blood tubes, mainly attributable to blood cell metabolism when glycolysis is not rapidly inhibited or blood cells cannot be rapidly separated from plasma. Although glycolysis inhibitors such as sodium fluoride (NaF) in combination with potassium oxalate (KOx) are currently used for overcoming this drawback, their efficacy for stabilizing blood glucose is seemingly limited, and probably lower than that of newer additives such as the citrate buffer. Therefore, we performed a critical analysis of the current scientific literature aimed to generate evidence-based information about the advantages of using citrate buffer in blood tubes compared to the more conventional NaF additive. Read More

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February 2018
4 Reads

Protein Carbamylation: Chemistry, Pathophysiological Involvement, and Biomarkers.

Adv Clin Chem 2018;84:1-38

Laboratory of Biochemistry and Molecular Biology, University of Reims Champagne-Ardenne, CNRS/URCA UMR No 7369 MEDyC, Reims, France; University Hospital of Reims, Reims, France.

Protein carbamylation refers to a nonenzymatic modification, which consists in the binding of isocyanic acid on protein functional groups. This reaction is responsible for the alteration in structural and functional properties of proteins, which participate in their molecular aging. Protein molecular aging is now considered a molecular substratum for the development of chronic and inflammatory diseases, including atherosclerosis, chronic kidney disease, or rheumatoid arthritis. Read More

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http://dx.doi.org/10.1016/bs.acc.2017.12.001DOI Listing
January 2018
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Preface.

Adv Clin Chem 2018;83:ix

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http://dx.doi.org/10.1016/S0065-2423(17)30078-1DOI Listing
January 2018

Liquid Biopsy: From Basic Research to Clinical Practice.

Adv Clin Chem 2018;83:73-119. Epub 2017 Nov 23.

Clínica Universidad de Navarra, Pamplona, Spain; The Health Research Institute of Navarra (IDISNA), Pamplona, Spain. Electronic address:

Liquid biopsy refers to the molecular analysis in biological fluids of nucleic acids, subcellular structures, especially exosomes, and, in the context of cancer, circulating tumor cells. In the last 10 years, there has been an intensive research in liquid biopsy to achieve a less invasive and more precise personalized medicine. Molecular assessment of these circulating biomarkers can complement or even surrogate tissue biopsy. Read More

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http://dx.doi.org/10.1016/bs.acc.2017.10.003DOI Listing
November 2017
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Locked Nucleic Acid Technology for Highly Sensitive Detection of Somatic Mutations in Cancer.

Adv Clin Chem 2018;83:53-72. Epub 2017 Nov 23.

Chiba University Hospital, Chiba, Japan.

The molecular diagnosis of the cancer mutational status is essential for modern clinical laboratory medicine. Mutations in EGFR, KRAS, BRAF, and PIK3CA genes are widely analyzed in solid tumors such as lung cancer, colorectal cancer, breast cancer, and melanoma. The allele-specific polymerase chain reaction, high-resolution melting, and Sanger sequencing are used for detecting and identifying gene mutations in many clinical laboratories. Read More

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http://dx.doi.org/10.1016/bs.acc.2017.10.002DOI Listing
November 2017
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Laboratory Assessment of Anemia.

Adv Clin Chem 2018;83:197-225. Epub 2017 Dec 2.

University Hospitals Cleveland Medical Center, Cleveland, OH, United States. Electronic address:

Anemia is one of the most common health problems in both industrialized and developing countries. It has been recognized by the World Health Organization as an important disorder leading to significant health care burden. Laboratory testing plays a significant role in the diagnosis of most types of anemia since the clinical diagnosis may not always be straightforward, especially with multiple underlying conditions. Read More

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http://dx.doi.org/10.1016/bs.acc.2017.10.006DOI Listing
December 2017

Indoor Tanning a Gianus Bifrons: Vitamin D and Human Cancer.

Adv Clin Chem 2018;83:183-196. Epub 2017 Dec 8.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Despite it is now undeniable that indoor tanning exposure is associated with a number of skin cancers, its favorable effects on vitamin D status may bear some underestimated and currently unexplored health benefits. Vitamin D is a fat-soluble vitamin naturally present in a limited number of foods, the concentration of which largely depends on ultraviolet (UV) B sources exposure in humans. A strong, graded, and inverse association has been documented between serum vitamin D and the risk of developing certain types of malignancy, especially colorectal, breast, lung, bladder, and kidney cancers. Read More

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http://dx.doi.org/10.1016/bs.acc.2017.10.005DOI Listing
December 2017
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Circulating Tumor Cells and Implications of the Epithelial-to-Mesenchymal Transition.

Adv Clin Chem 2018;83:121-181. Epub 2017 Dec 21.

London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada; Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada. Electronic address:

The majority of cancer-related deaths result from metastasis, the process by which cancer cells escape the primary tumor site and enter into the blood circulation in order to disseminate to secondary locations throughout the body. Tumor cells found within the circulation are referred to as circulating tumor cells (CTCs), and their detection and enumeration correlate with poor prognosis. The epithelial-to-mesenchymal transition (EMT) is a dynamic process that imparts epithelial cells with mesenchymal-like properties, thus facilitating tumor cell dissemination and contributing to metastasis. Read More

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http://dx.doi.org/10.1016/bs.acc.2017.10.004DOI Listing
December 2017
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Urinary Nucleosides and Deoxynucleosides.

Adv Clin Chem 2018;83:1-51. Epub 2017 Dec 7.

Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Urinary nucleosides and deoxynucleosides are mainly known as metabolites of RNA turnover and oxidative damage of DNA. For several decades these metabolites have been examined for their potential use in disease states including cancer and oxidative stress. Subsequent improvements in analytical sensitivity and specificity have provided a reliable means to measure these unique molecules to better assess their relationship to physiologic and pathophysiologic conditions. Read More

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http://dx.doi.org/10.1016/bs.acc.2017.10.001DOI Listing
December 2017
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Preface.

Adv Clin Chem 2017;82:ix

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http://dx.doi.org/10.1016/S0065-2423(17)30056-2DOI Listing
January 2017
2 Reads