652 results match your criteria Advances in clinical chemistry[Journal]


Preface.

Adv Clin Chem 2020 ;98:xi

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http://dx.doi.org/10.1016/S0065-2423(20)30084-6DOI Listing
January 2020

Biomarkers of vascular calcification in serum.

Adv Clin Chem 2020 27;98:91-147. Epub 2020 Apr 27.

Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Over the last decades, the association between vascular calcification (VC) and all-cause/cardiovascular mortality, especially in patients with high atherogenic status, such as those with diabetes and/or chronic kidney disease, has been repeatedly highlighted. For over a century, VC has been noted as a passive, degenerative, aging process without any treatment options. However, during the past decades, studies confirmed that mineralization of the arteries is an active, complex process, similar to bone genesis and formation. Read More

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Pleiotrophin: Activity and mechanism.

Authors:
Xu Wang

Adv Clin Chem 2020 12;98:51-89. Epub 2020 Mar 12.

School of Molecular Sciences, Arizona State University, Tempe, AZ, United States. Electronic address:

Pleiotrophin (PTN) is a potent mitogenic cytokine with a high affinity for the polysaccharide glycosaminoglycan (GAG). Although it is most strongly associated with neural development during embryogenesis and the neonatal period, its expression has also been linked to a plethora of other physiological events including cancer metastasis, angiogenesis, bone development, and inflammation. A considerable amount of research has been carried out to understand the mechanisms by which PTN regulates these events. Read More

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Advances in biomarker development in acetaminophen toxicity.

Adv Clin Chem 2020 27;98:35-50. Epub 2020 Apr 27.

Digestive and Liver Diseases Division, UT Southwestern Medical Center at Dallas, Dallas, TX, United States.

Acetaminophen liver injury is the most common cause of acute liver injury in the United States and several other countries. Diagnosis of acetaminophen-induced acute liver injury in the clinic is challenging due to the lack of validated and specific biomarkers. The following chapter provides an overview of recent advances evaluating candidate biomarkers in development for acetaminophen acute liver injury. Read More

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http://dx.doi.org/10.1016/bs.acc.2020.02.002DOI Listing

S100 family proteins in inflammation and beyond.

Adv Clin Chem 2020 17;98:173-231. Epub 2020 Apr 17.

Department of Surgery, Ohio State University, Columbus, OH, United States. Electronic address:

The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy metabolism, apoptosis, calcium homeostasis, cell cytoskeleton and microbial resistance. S100 proteins are also emerging as novel diagnostic markers for identifying and monitoring various diseases. Read More

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Aquaporins in health and disease.

Adv Clin Chem 2020 12;98:149-171. Epub 2020 Mar 12.

The Warren Alpert Medical School of Brown University, Providence, RI, United States.

Aquaporins (AQPs) are transmembrane channel proteins that mainly facilitate the water translocation through the plasma cell membrane. For several years these proteins have been extensively examined for their biologic role in health and their potential implication in different diseases. Technological improvements associated with the methods employed to evaluate the functions of the AQPs have provided us with significant new knowledge. Read More

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March 2020
2.646 Impact Factor

Biosensor platforms for rapid HIV detection.

Adv Clin Chem 2020 20;98:1-34. Epub 2020 Mar 20.

DBT-National Institute of Animal Biotechnology (DBT-NIAB), Hyderabad, Telangana, India. Electronic address:

Human immunodeficiency virus (HIV), a type of lentivirus (a subgroup of retrovirus), causes acquired immunodeficiency syndrome (AIDS). This pathophysiologic state destroys the immune system allowing opportunistic infections, cancer and other life-threatening diseases to thrive. Although many analytic tools including enzyme-linked immunoassay (ELISA), indirect and line immunoassay, Western blotting, radio-immunoprecipitation, nucleic acid amplification testing (NAAT) have been developed to detect HIV, recent developments in nanosensor technology have prompted its use as a novel diagnostic approach. Read More

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Preface.

Adv Clin Chem 2020 ;97:xi

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http://dx.doi.org/10.1016/S0065-2423(20)30069-XDOI Listing
January 2020

Advances in extracellular vesicles analysis.

Adv Clin Chem 2020 17;97:73-116. Epub 2020 Feb 17.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. Electronic address:

Extracellular vesicles (EVs) play an important role in intercellular communication in normal cellular process and pathological conditions by facilitating the transport of cellular content from one cell to another. EVs as conveyors of various biological molecules with their ability to redirect effects on a target cell physiological function in cell type-specific manner makes EVs an excellent candidate for drug delivery vehicle in disease therapy. Moreover, unique characteristics and contents of EVs which differ depends on cellular origin and physiological state make them a valuable source of diagnostic biomarker. Read More

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February 2020

Cell free DNA biology and its involvement in breast carcinogenesis.

Adv Clin Chem 2020 14;97:171-223. Epub 2020 Feb 14.

Instituto Nacional de Câncer (INCA-HCIII), Rio de Janeiro, Brazil.

Liquid biopsy represents a procedure for minimally invasive analysis of non-solid tissue, blood and other body fluids. It comprises a set of analytes that includes circulating tumor cells (CTCs) and circulating free DNA (cfDNA), RNA, long noncoding RNA (lncRNA) and micro RNA (miRNA), as well as extracellular vesicles. These novel analytes represent an alternative tool to complement diagnosis and monitor and predict response to treatment of the tumoral process and may be used for other disease processes such viral and parasitic infection. Read More

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February 2020

Genomics of hypertriglyceridemia.

Adv Clin Chem 2020 14;97:141-169. Epub 2020 Feb 14.

Department of Cardiology, Kanazawa University, Graduate School of Medical Sciences, Kanazawa, Japan.

With regard to heritability of phenotypes, the serum triglyceride level is considered to be highly heritable, with approximately 50% of its variability estimated to derive from parents. Thus, approximately 50% could be modifiable via environmental factors, including lifestyle and medications. Lipoproteins are definitive risk factors for atherosclerotic cardiovascular disease (ASCVD); among these, low-density lipoprotein (LDL) particles have been established as a causal factor for the development of ASCVD. Read More

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February 2020

Liquid biopsy in ovarian cancer.

Adv Clin Chem 2020 14;97:13-71. Epub 2020 Feb 14.

Analysis of Circulating Tumor Cells Lab, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, University Campus, Athens, Greece. Electronic address:

Ovarian cancer has the worst survival rate because it is typically diagnosed at advanced stage. Despite treatment, the disease commonly recurs due to chemo-resistance. Liquid biopsy, based on minimally invasive blood tests, has the advantage of following tumor evolution in real time, offering novel insights on cancer prevention and treatment. Read More

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February 2020

Long non-coding RNA HOTAIR in cervical cancer: Molecular marker, mechanistic insight, and therapeutic target.

Adv Clin Chem 2020 8;97:117-140. Epub 2020 Feb 8.

Xiangya Nursing School, Central South University, Changsha, Hunan, China. Electronic address:

Cervical cancer is a common gynecologic malignant tumor with high mortality. HOX transcript antisense RNA (HOTAIR), a trans-acting long non-coding RNA (lncRNA) containing six exons in humans, is transcribed from the antisense strand of homeobox gene C cluster. This lncRNA serves as a modular scaffold for gene silencing and protein ubiquitination. Read More

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February 2020

Metaproteomic analysis of human gut microbiome in digestive and metabolic diseases.

Authors:
Sheng Pan Ru Chen

Adv Clin Chem 2020 17;97:1-12. Epub 2020 Feb 17.

Division of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX, United States.

Metaproteomics, as a subfield of proteomics, has quickly emerged as a pivotal tool for global characterization of a microbiome system at a functional level. It has been increasingly applied in studying human digestive and metabolic diseases, and provides information-rich data to identify the dysbiosis of human gut microbiome related to healthy or disease states to elucidate the molecular events underlying host-microbiota interplays. While significant technical challenges still exist, this emerging technology has been demonstrated to provide essential information in interrogating functional changes in the human gut microbiome, complementary to metagenomics and metatranscriptomics. Read More

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February 2020

Preface.

Adv Clin Chem 2020 ;96:xi-xii

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http://dx.doi.org/10.1016/S0065-2423(20)30058-5DOI Listing
January 2020

Neurotransmitter, neuropeptide and gut peptide profile in PCOS-pathways contributing to the pathophysiology, food intake and psychiatric manifestations of PCOS.

Authors:
Ioana R Ilie

Adv Clin Chem 2020 12;96:85-135. Epub 2019 Dec 12.

Department of Endocrinology, University of Medicine and Pharmacy 'Iuliu-Hatieganu', Cluj-Napoca, Romania. Electronic address:

Polycystic ovary syndrome (PCOS) is a major health problem with a heterogeneous hormone-imbalance and clinical presentation across the lifespan of women. Increased androgen production and abnormal gonadotropin-releasing hormone (GnRH) release and gonadotropin secretion, resulting in chronic anovulation are well-known features of the PCOS. The brain is both at the top of the neuroendocrine axis regulating ovarian function and a sensitive target of peripheral gonadal hormones and peptides. Read More

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December 2019

Omics and the molecular exercise physiology.

Adv Clin Chem 2020 18;96:55-84. Epub 2019 Dec 18.

Postgraduate Program in Health Promotion, University of Franca (Unifran), Franca, São Paulo, Brazil; Laboratory of Molecular Exercise Physiology-University Center UDF, Brasília, Brazil. Electronic address:

Exercise is a well-known non-pharmacologic agent used to prevent and treat a wide range of pathologic conditions such as metabolic and cardiovascular disease. In this sense, the classic field of exercise physiology has determined the main theoretical and practical bases of physiologic adaptations in response to exercise. However, the last decades were marked by significant advances in analytical laboratory techniques, where the field of biochemistry, genetics and molecular biology promoted exercise science to enter a new era. Read More

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December 2019

New biomarkers in non-Hodgkin lymphoma and acute leukemias.

Adv Clin Chem 2020 3;96:19-53. Epub 2020 Mar 3.

Unidad de Investigación Biomédica 02, UMAE HE, CMNO, IMSS, Guadalajara, Jalisco, Mexico; Programa Internacional, Facultad de Medicina, Universidad Autónoma de Guadalajara, Zapopan, Jalisco, Mexico; Departamento de Inmunologia y Reumatologia, Hospital General de Occidente, Secretaria de Salud Jalisco, Zapopan, Jalisco, Mexico. Electronic address:

Biomarkers play a critical role in the medical care of patients with cancer, including in early detection of the disease, diagnostic accuracy, risk stratification, treatment, and follow-up. Biomarkers in hematological malignancies can support the redefinition of the diagnosis and adjustments in the treatment plan. Biomarkers can be classified into 4 categories: (1) protein antigens, (2) cytogenetic abnormalities, (3) genetic polymorphisms, and (4) gene expression. Read More

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New markers in Parkinson's disease.

Authors:
Anastasia Bougea

Adv Clin Chem 2020 2;96:137-178. Epub 2020 Jan 2.

Neurochemistry Laboratory, 1st Department of Neurology and Movement Disorders, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece; Neuroscience Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. Electronic address:

Parkinson's disease (PD) is a chronic, debilitating neurodegenerative disorder characterized clinically by a variety of progressive motor and nonmotor symptoms. Currently, there is a dearth of diagnostic tools available to predict, diagnose or mitigate disease risk or progression, leading to a challenging dilemma within the healthcare management system. The search for a reliable biomarker for PD that reflects underlying pathology is a high priority in PD research. Read More

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January 2020

Revisiting immune complexes: Key to understanding immune-related diseases.

Adv Clin Chem 2020 10;96:1-17. Epub 2019 Dec 10.

Course of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. Electronic address:

Immune complexes (ICs) formed by foreign or self-antigens and antibodies in biological fluids affect various tissues and are thought to cause several diseases. Biological and physical properties of IC, abnormal IC amounts, IC deposition and their relationships with disease pathogenesis had been studied. However, the relationship between ICs and each disease is not well understood and little is known of what determined ICs deposition in particular organ and why different organs are affected in different diseases. Read More

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December 2019

Preface.

Adv Clin Chem 2020 ;95:xi-xii

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http://dx.doi.org/10.1016/S0065-2423(20)30032-9DOI Listing

Vascular and valvular calcification biomarkers.

Adv Clin Chem 2020 15;95:73-103. Epub 2019 Oct 15.

Fondazione CNR-Regione Toscana G. Monasterio, Pisa, Italy. Electronic address:

Vascular and valvular calcification constitutes a major health problem with serious clinical consequences. It is important for medical laboratorians to improve their knowledge on this topic and to know which biological markers may have a potential interest and might be useful for diagnosis and for management of ectopic calcifications. This review focuses on the pathophysiological mechanisms of vascular and valvular calcification, with emphasis on the mechanisms that are different for the two types of events, which underscore the need for differentiated healthcare, and explain different response to therapy. Read More

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Biochemistry of blood platelet activation and the beneficial role of plant oils in cardiovascular diseases.

Authors:
Beata Olas

Adv Clin Chem 2020 31;95:219-243. Epub 2019 Oct 31.

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland. Electronic address:

The main function of blood platelets is to form hemostatic plugs and enable thrombosis. These properties, however, can be greatly influenced by dietary components which may inhibit certain steps of platelet activation, including platelet aggregation. Such inhibition can play a role in the prophylaxis and treatment of cardiovascular diseases associated with blood platelet hyperactivation. Read More

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Tryptophan in health and disease.

Adv Clin Chem 2020 15;95:165-218. Epub 2019 Oct 15.

Institute of Paediatric Research-Città della Speranza, Padua, Italy. Electronic address:

Tryptophan (TRP), an essential amino acid in mammals, is involved in several physiological processes including neuronal function, immunity, and gut homeostasis. In humans, TRP is metabolized via the kynurenine and serotonin pathways, leading to the generation of biologically active compounds, such as serotonin, melatonin and niacin. In addition to endogenous TRP metabolism, resident gut microbiota also contributes to the production of specific TRP metabolites and indirectly influences host physiology. Read More

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Exosomes of male reproduction.

Adv Clin Chem 2020 16;95:149-163. Epub 2019 Sep 16.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States. Electronic address:

Exosomes are nanosized membrane vesicles secreted by wide variety of cells and found in abundance in biological fluids including semen. They contain cargo of lipids, proteins, microRNAs and mRNAs, and are known to play a major role in intracellular communication. Seminal exosomes mainly include epididymosomes and prostasomes. Read More

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April 2020
2.646 Impact Factor

Long noncoding RNAs in cancer: From discovery to therapeutic targets.

Adv Clin Chem 2020 31;95:105-147. Epub 2019 Oct 31.

Center of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States; Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States; Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Long noncoding RNAs (lncRNAs) have recently gained considerable attention as key players in biological regulation; however, the mechanisms by which lncRNAs govern various disease processes remain mysterious and are just beginning to be understood. The ease of next-generation sequencing technologies has led to an explosion of genomic information, especially for the lncRNA class of noncoding RNAs. LncRNAs exhibit the characteristics of mRNAs, such as polyadenylation, 5' methyl capping, RNA polymerase II-dependent transcription, and splicing. Read More

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April 2020
2.646 Impact Factor

Advances in diagnostic microfluidics.

Adv Clin Chem 2020 15;95:1-72. Epub 2019 Oct 15.

Thayer School of Engineering, Dartmouth College, Hanover, NH, United States; Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. Electronic address:

Microfluidics is an emerging field in diagnostics that allows for extremely precise fluid control and manipulation, enabling rapid and high-throughput sample processing in integrated micro-scale medical systems. These platforms are well-suited for both standard clinical settings and point-of-care applications. The unique features of microfluidics-based platforms make them attractive for early disease diagnosis and real-time monitoring of the disease and therapeutic efficacy. Read More

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April 2020
2.646 Impact Factor

Preface.

Adv Clin Chem 2020 ;94:xi

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http://dx.doi.org/10.1016/S0065-2423(20)30008-1DOI Listing
February 2020

Metabolomics in genetic testing.

Adv Clin Chem 2020 6;94:85-153. Epub 2019 Sep 6.

Department of Obstetrics and Gynecology, University of Tennessee College of Medicine, Chattanooga, TN, United States; Department of Biology, Geology and Environmental Sciences, University of Tennessee at Chattanooga, Chattanooga, TN, United States.

Metabolomics is an intriguing field of study providing a new readout of the biochemical activities taking place at the moment of sampling within a subject's biofluid or tissue. Metabolite concentrations are influenced by several factors including disease, environment, drugs, diet and, importantly, genetics. Metabolomics signatures, which describe a subject's phenotype, are useful for disease diagnosis and prognosis, as well as for predicting and monitoring the effectiveness of treatments. Read More

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February 2020

Clotting factors: Clinical biochemistry and their roles as plasma enzymes.

Adv Clin Chem 2020 18;94:31-84. Epub 2019 Oct 18.

University of Florida, Department of Pathology, Immunology & Laboratory Medicine, Gainesville, FL, United States. Electronic address:

The purpose of this review is to describe structure and function of the multiple proteins of the coagulation system and their subcomponent domains. Coagulation is the process by which flowing liquid blood plasma is converted to a soft, viscous gel entrapping the cellular components of blood including red cells and platelets and thereby preventing extravasation of blood. This process is triggered by the minimal proteolysis of plasma fibrinogen. Read More

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February 2020

Organokines in disease.

Adv Clin Chem 2020 12;94:261-321. Epub 2019 Aug 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, South Korea. Electronic address:

Studies have linked obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD) and dementia. Their relationship to the incidence and progression of these disease states suggests an interconnected pathogenesis involving chronic low-grade inflammation and oxidative stress. Metabolic syndrome represents comorbidities of central obesity, insulin resistance, dyslipidemia, hypertension and hyperglycemia associated with increased risk of type 2 diabetes, NAFLD, atherosclerotic CVD and neurodegenerative disease. Read More

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February 2020

Epigenetic reprogramming and potential application of epigenetic-modifying drugs in acquired chemotherapeutic resistance.

Adv Clin Chem 2020 21;94:219-259. Epub 2019 Aug 21.

Department of Environmental Toxicology, The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Lubbock, TX, United States. Electronic address:

Chemotherapy is the most common clinical choice of treatment for cancer, however, acquired chemoresistance is a major challenge that limits the successful outcome of this option. Systematic review of in vitro, in vivo, preclinical and clinical studies suggests that acquired chemoresistance is polygenic, progressive, and involve both genetic and epigenetic heterogeneities and perturbations. Various mechanisms that confer resistance to chemotherapy are tightly controlled by epigenetic regulations. Read More

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February 2020

Myokines: The endocrine coupling of skeletal muscle and bone.

Adv Clin Chem 2020 8;94:155-218. Epub 2019 Aug 8.

IRCCS Istituto Ortopedico Galeazzi, Laboratory of Experimental Biochemistry & Molecular Biology, Milan, Italy; Gdańsk University of Physical Education & Sport, Gdańsk, Pomorskie, Poland. Electronic address:

Bone and skeletal muscle are integrated organs and their coupling has been considered mainly a mechanical one in which bone serves as attachment site to muscle while muscle applies load to bone and regulates bone metabolism. However, skeletal muscle can affect bone homeostasis also in a non-mechanical fashion, i.e. Read More

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February 2020

Hypertensive disorders of pregnancy: Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome.

Adv Clin Chem 2020 12;94:1-30. Epub 2019 Aug 12.

Juntendo University Graduate School of Medicine, Chiba, Japan.

Hypertensive disorders of pregnancy (HDP) is the most common and widely known as serious complication of pregnancy. As this syndrome is a major leading cause of maternal, fetal, and neonatal morbidity/mortality worldwide, many studies have sought to identify candidate molecules as potential disease biomarkers (DBMs) for use in clinical examinations. Accumulating evidence over the past 2 decades that the many proteolytic peptides appear in human humoral fluids, including peripheral blood, in association with an individual's health condition. Read More

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http://dx.doi.org/10.1016/bs.acc.2019.07.007DOI Listing
February 2020

Preface.

Adv Clin Chem 2019 ;93:xi

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http://dx.doi.org/10.1016/S0065-2423(19)30094-0DOI Listing
December 2019

Cytokines in heart failure.

Adv Clin Chem 2019 14;93:63-113. Epub 2019 Aug 14.

Department of Carcinogenesis and Molecular Biology, Institute of Oncology Bucharest, Bucharest, Romania. Electronic address:

The natural history of heart failure (HF) is not linear, because changes in the heart structure and function start long before the disease becomes clinically evident. Many different cytokines originating from intracardiac tissues (cardiomyocytes, cardiac endothelial cells, cardiac fibroblasts, and cardiac infiltrated immune cells) or extracardiac tissues (adipose tissue, gut, and lymphoid organs) have been identified in HF. Because the levels of circulating cytokines correlate with the development and severity of HF, these mediators may have both pathophysiological importance, through their ability to modulate inflammation, myocyte stress/stretch, myocyte injury and apoptosis, fibroblast activation and extracellular matrix remodeling, and utility as clinical predictive biomarkers. Read More

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December 2019

Periodontal disease: From the lenses of light microscopy to the specs of proteomics and next-generation sequencing.

Adv Clin Chem 2019 30;93:263-290. Epub 2019 Aug 30.

Section of Periodontology and Dental Prevention, Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Periodontal disease entails the inflammatory destruction of the tooth supporting (periodontal) tissues as a result of polymicrobial colonization of the tooth surface in the form of biofilms. Extensive data collected over the past decades on this chronic disease demonstrate that its progression is infrequent and episodic, and the susceptibility to it can vary among individuals. Physical assessments of previously occurring damage to periodontal tissues remain the cornerstone of detection and diagnosis, whereas traditionally used diagnostic procedures do neither identify susceptible individuals nor distinguish between disease-active and disease-inactive periodontal sites. Read More

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December 2019

Evaluation of analytical performance of immunoassay methods for cTnI and cTnT: From theory to practice.

Adv Clin Chem 2019 27;93:239-262. Epub 2019 Aug 27.

Department of Laboratory Medicine, University Hospital, Padova, Italy.

Current guidelines worldwide recommend cardiac troponins I (cTnI) and T (cTnT) as the biomarkers of choice for the differential diagnosis of acute coronary syndrome (ACS), and the measurement of the 99th upper reference population limit (URL) value for cardiac troponins, with an imprecision of ≤10 CV%. Measuring the 99th URL of cTnI and cTnT is a challenging analytical task due to low biomarker concentrations present in healthy subjects. Therefore, since the year 2006, several manufacturers have established new generation cTnI and cTnT immunoassays with an improved analytical sensitivity in accordance with the quality specifications described in international guidelines, the more recent of which state that only immunoassays that meet the required quality specifications should be considered "high-sensitivity" methods. Read More

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December 2019

Biomarkers in aggression.

Adv Clin Chem 2019 11;93:169-237. Epub 2019 Sep 11.

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Aggressive behavior exerts an enormous impact on society remaining among the main causes of worldwide premature death. Effective primary interventions, relying on predictive models of aggression that show adequate sensitivity and specificity are currently lacking. One strategy to increase the accuracy and precision of prediction would be to include biological data in the predictive models. Read More

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December 2019
2 Reads

Recent advances in the determination of insulins from biological fluids.

Adv Clin Chem 2019 11;93:115-167. Epub 2019 Sep 11.

Institute of Biochemistry/Center for Preventive Doping Research, German Sport University Cologne, Cologne, Germany; European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn, Germany.

The qualitative and quantitative determination of insulin and its related substances (e. g., C-peptide) is of great importance in many different areas of analytical chemistry. Read More

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December 2019

Lectin biosensors in cancer glycan biomarker detection.

Authors:
M Luísa S Silva

Adv Clin Chem 2019 20;93:1-61. Epub 2019 Aug 20.

Centre of Chemical Research, Autonomous University of Hidalgo State, Pachuca, Hidalgo, México. Electronic address:

Cancer has high incidence and it will continue to increase over the next decades. Detection and quantification of cancer-associated biomarkers is frequently carried out for diagnosis, prognosis and treatment monitoring at various disease stages. It is well-known that glycosylation profiles change significantly during oncogenesis. Read More

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December 2019
3 Reads

Preface.

Adv Clin Chem 2019;92:ix

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http://dx.doi.org/10.1016/S0065-2423(19)30083-6DOI Listing
October 2019

Amino and organic acid analysis: Essential tools in the diagnosis of inborn errors of metabolism.

Adv Clin Chem 2019 8;92:59-103. Epub 2019 Jun 8.

Department of Pathology, UT Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Inborn errors of metabolism (IEMs) are a large class of genetic disorders that result from defects in enzymes involved in energy production and metabolism of nutrients. For every metabolic pathway, there are defects that can occur and potentially result in an IEM. While some defects can go undetected in one's lifetime, some have moderate to severe clinical consequences. Read More

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October 2019
1 Read

Proteomics of reproduction: Prospects and perspectives.

Adv Clin Chem 2019 24;92:217-243. Epub 2019 May 24.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States. Electronic address:

In recent years, proteomics has been used widely in reproductive research in order to understand the molecular mechanisms related to gametes at the cellular level and the role of proteins involved in fertilization. Network and pathway analysis using bioinformatic tools have paved way to obtain a wider picture on the possible pathways associated with the key differentially expressed proteins (DEPs) and its implication in various infertility scenarios. A brief overview of advanced techniques and bioinformatic tools used for reproductive proteomics is presented. Read More

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http://dx.doi.org/10.1016/bs.acc.2019.04.005DOI Listing
October 2019
2.646 Impact Factor

Toward a holistic approach for diagnosing sepsis in the emergency department.

Adv Clin Chem 2019;92:201-216. Epub 2019 May 24.

Section of Clinical Biochemistry, University of Verona, Verona, Italy. Electronic address:

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http://dx.doi.org/10.1016/bs.acc.2019.04.004DOI Listing
October 2019
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Advances in biomarker detection: Alternative approaches for blood-based biomarker detection.

Adv Clin Chem 2019 10;92:141-199. Epub 2019 Jun 10.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. Electronic address:

In the clinical setting, a blood sample is typically the starting point for biomarker search and discovery. Mass spectrometry (MS) is a highly sensitive and informative method for characterizing a very wide range of metabolites and proteins and is therefore a potentially powerful tool for biomarker discovery. However, the physicochemical characteristics of blood coupled with very large ranges of protein and metabolite concentrations present a significant technical obstacle for resolving and quantifying putative biomarkers by MS. Read More

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http://dx.doi.org/10.1016/bs.acc.2019.04.003DOI Listing
October 2019
4 Reads

Lipid trafficking in cardiovascular disease.

Adv Clin Chem 2019 29;92:105-140. Epub 2019 May 29.

Department of Food and Drug, University of Parma, Parma, Italy.

The reduction of plasma apolipoprotein B (apoB) containing lipoproteins has long been pursued as the main modifiable risk factor for the development of cardiovascular disease (CVD). This has led to an intense search for strategies aiming at reducing plasma apoB-lipoproteins, culminating in reduction of overall CV risk. Despite 3 decades of progress, CVD remains the leading cause of morbidity and mortality worldwide and, as such, new therapeutic targets are still warranted. Read More

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http://dx.doi.org/10.1016/bs.acc.2019.04.002DOI Listing
October 2019

Advances in electrochemical immunosensors.

Adv Clin Chem 2019 29;92:1-57. Epub 2019 May 29.

Çanakkale Onsekiz Mart University, Faculty of Engineering, Bioengineering Department, Çanakkale, Turkey.

Immunosensors are compact tools on which antibody and antigen interactions are formed. The specific interaction between antibody and antigen is detected by using a transducer and an electrical signal is measured. This specific interaction between these molecules makes immunosensor very attractive for several applications in different fields. Read More

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http://dx.doi.org/10.1016/bs.acc.2019.04.006DOI Listing
October 2019

Preface.

Adv Clin Chem 2019 ;91:xi

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http://dx.doi.org/10.1016/S0065-2423(19)30051-4DOI Listing
July 2019
6 Reads