294 results match your criteria Advances in biological regulation[Journal]


Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship.

Adv Biol Regul 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurosurgery, Westchester Medical Center / New York Medical College, Valhalla, NY, 10595, USA.

Activation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical PI3K/Akt/mTOR signaling cascade is commonly upregulated due to loss of the tumor suppressorm PTEN, a phosphatase that acts antagonistically to the kinase (PI3K) in conversion of PIP2 to PIP3. mTOR forms two multiprotein complexes, mTORC1 and mTORC2 which are composed of discrete protein binding partners to regulate cell growth, motility, and metabolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2019.03.003DOI Listing

Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction.

Adv Biol Regul 2019 Apr 6. Epub 2019 Apr 6.

Department of Biological Sciences, University of Bergen, Bergen, 5008, Norway. Electronic address:

Biomolecular interactions between proteins and polyphosphoinositides (PPIn) are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the development of many diseases. PPIn are phosphorylated derivatives of phosphatidylinositol and consist of seven species with different phosphate combinations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2019.04.001DOI Listing

Phosphoinositide spatially free AKT/PKB activation to all membrane compartments.

Adv Biol Regul 2019 Apr 11. Epub 2019 Apr 11.

University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University Ave, Madison, WI, 53706, USA. Electronic address:

Ser and Thr kinase AKT also known as protein kinase B (PKB) was discovered more than two and half decades ago and is one of the key downstream molecules in the phosphoinositide 3-kinase signaling pathways. The pleiotropic effects of this kinase have attracted intense interest and limelight in cancer biology, cancer therapy, diabetes, and cardiovascular diseases. Authors may refer to other more comprehensive and recent reviews on AKT/PKB (Manning and Cantley, 2007; Manning and Toker, 2017). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2019.04.002DOI Listing

Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and nutraceuticals.

Adv Biol Regul 2019 Mar 15. Epub 2019 Mar 15.

Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA, 27834. Electronic address:

Mutations at the TP53 gene are readily detected (approximately 50-75%) in pancreatic ductal adenocarcinoma (PDAC) patients. TP53 was previously thought to be a difficult target as it is often mutated, deleted or inactivated on both chromosomes in certain cancers. In the following study, the effects of restoration of wild-type (WT) TP53 activity on the sensitivities of MIA-PaCa-2 pancreatic cancer cells to the MDM2 inhibitor nutlin-3a in combination with chemotherapy, targeted therapy, as well as, nutraceuticals were examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2019.03.002DOI Listing
March 2019
4 Reads

Fructose-1,6-bisphosphatase: From a glucose metabolism enzyme to multifaceted regulator of a cell fate.

Adv Biol Regul 2019 Mar 9. Epub 2019 Mar 9.

Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland. Electronic address:

Fructose-1,6-bisphosphatase (FBPase) is one of the ancient, evolutionarily conserved enzymes of carbohydrate metabolism. It has been described for a first time in 1943, however, for the next half a century mostly kinetic and structural parameters of animal FBPases have been studied. Discovery of ubiquitous expression of the muscle isozyme of FBPase, thus far considered to merely regulate glycogen synthesis from carbohydrate precursors, and its nuclear localisation in several cell types has risen new interest in the protein, resulting in numerous publications revealing complex functions/properties of FBPase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2019.03.001DOI Listing

Pancreatic cancer tumorspheres are cancer stem-like cells with increased chemoresistance and reduced metabolic potential.

Adv Biol Regul 2019 Feb 23. Epub 2019 Feb 23.

Metabolic Signalling Group, School of Pharmacy & Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, 6102, Australia. Electronic address:

Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. Here we investigated the characteristics of a population of pancreatic cancer tumorspheres derived from different human pancreatic cancer cell lines and a primary line from a genetically engineered KPC mouse model, using flow cytometry and western blotting to analyse surface and stemness markers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2019.02.001DOI Listing
February 2019
1 Read

Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune.

Adv Biol Regul 2019 Jan 3. Epub 2019 Jan 3.

Friedrich Schiller University Jena, Institute of Microbiology, Jena, Germany. Electronic address:

Mushroom forming basidiomycete Schizophyllum commune has been used as a tractable model organism to study fungal sexual development. Ras signaling activation via G-protein-coupled receptors (GPCRs) has been postulated to play a significant role in the mating and development of S. commune. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183017
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2019.01.001DOI Listing
January 2019
12 Reads

Noncoding RNA genes in cancer pathogenesis.

Adv Biol Regul 2019 Jan 13;71:219-223. Epub 2018 Dec 13.

Department of Cancer Biology and Genetics, The Wexner Medical Center, Columbus, OH, USA. Electronic address:

By using chronic lymphocytic leukemia as target for discovery in cancer pathogenesis we discovered that the great majority of CLLs (75-85%) carry a deletion of miR-15a and miR-16-1 at 13q14. We also discovered that miR-15/16 are negative regulators of the BCL2 oncogene. Thus the loss of the two negative regulators causes BCL2 overexpression and leukemia. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183016
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.12.002DOI Listing
January 2019
10 Reads

A novel role for DGATs in cancer.

Adv Biol Regul 2018 Dec 13. Epub 2018 Dec 13.

Stony Brook Cancer Center and the Department of Medicine, Stony Brook University, Health Sciences Center, Stony Brook, NY, 11794, USA; The Northport VA Medical Center, Northport, NY, 11768, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.12.001DOI Listing
December 2018

Heterogeneity in myeloproliferative neoplasms: Causes and consequences.

Adv Biol Regul 2019 Jan 22;71:55-68. Epub 2018 Nov 22.

MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, United Kingdom; NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK. Electronic address:

Myeloproliferative neoplasms (MPNs) are haematopoietic stem cell-derived clonal disorders characterised by proliferation of some or all myeloid lineages, depending on the subtype. MPNs are classically categorized into three disease subgroups; essential thrombocythaemia (ET), polycythaemia vera (PV) and primary myelofibrosis (PMF). The majority (>85%) of patients carry a disease-initiating or driver mutation, the most prevalent occurring in the janus kinase 2 gene (JAK2 V617F), followed by calreticulin (CALR) and myeloproliferative leukaemia virus (MPL) genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.11.007DOI Listing
January 2019
2 Reads

Sulforaphane as anticancer agent: A double-edged sword? Tricky balance between effects on tumor cells and immune cells.

Adv Biol Regul 2019 Jan 22;71:79-87. Epub 2018 Nov 22.

Section Molecular Immunology, Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

Sulforaphane (SFN) is a naturally occurring isothiocyanate derived from cruciferous vegetables such as broccoli. It has been reported to inhibit the growth of a variety of cancers, such as breast, prostate, colon, skin, lung, gastric or bladder cancer. SFN is supposed to act primarily as an antioxidant due to the activation of the Nrf2-Keap1 signaling pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.11.006DOI Listing
January 2019

Effective angiogenesis requires regulation of phosphoinositide signaling.

Adv Biol Regul 2019 Jan 26;71:69-78. Epub 2018 Nov 26.

Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Victoria, 3800, Australia. Electronic address:

Phosphoinositide signaling regulates numerous downstream effectors that mediate cellular processes which influence cell cycle progression, migration, proliferation, growth, survival, metabolism and vesicular trafficking. A prominent role for phosphoinositide 3-kinase, which generates phosphatidylinositol 3,4,5-trisphosphate, a phospholipid that activates a plethora of effectors including AKT and FOXO during embryonic and postnatal angiogenesis, has been described. In addition, phosphatidylinositol 3-phosphate signaling is required for endosomal trafficking, which contributes to vascular remodeling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.11.008DOI Listing
January 2019

Intra- and intercellular trafficking in sphingolipid metabolism in myelination.

Adv Biol Regul 2019 Jan 23;71:97-103. Epub 2018 Nov 23.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA. Electronic address:

The myelin sheath, produced by oligodendrocytes in the central nervous system, provides essential electrical insulation to neurons, but also is critical for viability of neurons. Both the protein and lipid composition of this fascinating membrane is unique. Here the focus is on the sphingolipids that are highly abundant in myelin and, in particular, how they are produced. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183015
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469711PMC
January 2019
1 Read

Sphingolipids in adipose tissue: What's tipping the scale?

Adv Biol Regul 2018 Dec 15;70:19-30. Epub 2018 Oct 15.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA; Hunter Holmes McGuire Veteran's Affairs Medical Center, Richmond, VA, USA. Electronic address:

Adipose tissue lies at the heart of obesity, mediating its many effects upon the rest of the body, with its unique capacity to expand and regenerate, throughout the lifespan of the organism. Adipose is appreciated as an endocrine organ, with its myriad adipokines that elicit both physiological and pathological outcomes. Sphingolipids, bioactive signaling molecules, affect many aspects of obesity and the metabolic syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.10.002DOI Listing
December 2018
21 Reads

Alcoholic and non-alcoholic fatty liver disease: Focus on ceramide.

Adv Biol Regul 2018 Dec 14;70:40-50. Epub 2018 Nov 14.

Department of Physiology, University of Kentucky College of Medicine, 800 Rose Str., MS 508, Lexington, KY, 40536, United States. Electronic address:

Sphingolipids are class of metabolically distinct lipids that play structural and signaling functions in all organisms. Sphingolipid metabolism is deregulated during various diseases such as cancer, neurological and immune disorders, and metabolic syndrome. With the advancement of sphingo-lipidomics and sphingo-genomics, an understanding of the specific roles of ceramide, the quintessential bioactive sphingolipid, in fatty liver disease has taken shape. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183014
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.11.004DOI Listing
December 2018
11 Reads

The role of sphingolipids is acute kidney injury.

Adv Biol Regul 2018 Dec 13;70:31-39. Epub 2018 Nov 13.

Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA. Electronic address:

Acute kidney injury (AKI) is most simply defined as the rapid loss of kidney function in a matter of hours to days. AKI can manifest in a number of ways including pre-renal, post-renal, or intrinsic AKI. During acute kidney injury, multiple pathogenic processes are activated including inflammation, cell death, and the generation of reactive oxygen species, just to name a few. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183013
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.11.003DOI Listing
December 2018
18 Reads

Introduction to the special issue on sphingolipid signaling in chronic disease.

Adv Biol Regul 2018 Dec 14;70:1-2. Epub 2018 Nov 14.

Department of Biochemistry and Molecular Biology, Mann T. and Sara D. Lowry Chair of Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183015
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.11.005DOI Listing
December 2018
2 Reads

Phospholipase C-β1 interacts with cyclin E in adipose- derived stem cells osteogenic differentiation.

Adv Biol Regul 2019 Jan 5;71:1-9. Epub 2018 Nov 5.

Section of Human Anatomy, Department of Biomedical and Neuromotor Sciences, University of Bologna, via Irnerio 48, 40126, Bologna, Italy. Electronic address:

Adipose-derived stem cells (ADSCs) are multipotent mesenchymal stem cells that have the ability to differentiate into several cell types, including chondrocytes, osteoblasts, adipocytes, and neural cells. Given their easy accessibility and abundance, they became an attractive source of mesenchymal stem cells, as well as candidates for developing new treatments for reconstructive medicine and tissue engineering. Our study identifies a new signaling pathway that promotes ADSCs osteogenic differentiation and links the lipid signaling enzyme phospholipase C (PLC)-β1 to the expression of the cell cycle protein cyclin E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.11.001DOI Listing
January 2019
1 Read

Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold.

Adv Biol Regul 2019 Jan 27;71:118-127. Epub 2018 Oct 27.

Inositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address:

The protein kinase family is characterized by substantial conservation of architectural elements that are required for both ATP binding and phosphotransferase activity. Many of these structural features have also been identified in homologous enzymes that phosphorylate a variety of alternative, non-protein substrates. A comparative structural analysis of these different kinase sub-classes is a portal to a greater understanding of reaction mechanisms, enzyme regulation, inhibitor-development strategies, and superfamily-level evolutionary relationships. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183014
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.10.006DOI Listing
January 2019
10 Reads

Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer.

Adv Biol Regul 2019 Jan 26;71:141-146. Epub 2018 Oct 26.

Health Science Center, Stony Brook University, 100 Nicolls Road, L4, 182, 11794, Stony Brook, NY, USA. Electronic address:

Extensive research conducted in the last three decades has identified the roles for the main bioactive sphingolipids, namely ceramide, sphingosine, and sphingosine 1-phosphate (S1P) as key regulators of cellular homeostasis, growth and death. One of the major groups of enzymes in the ceramide pathway, ceramidases, converts ceramide into sphingosine and fatty acids, with sphingosine being further metabolized to S1P. Thus, these enzymes play important roles in the network controlling the functions associated with these bioactive sphingolipids. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183015
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347532PMC
January 2019
8 Reads

Sphingoid bases and their involvement in neurodegenerative diseases.

Adv Biol Regul 2018 Dec 23;70:65-73. Epub 2018 Oct 23.

Department of Physiology, University of Kentucky, Lexington, KY, USA. Electronic address:

Sphingoid bases (also known as long-chain bases) form the backbone of sphingolipids. Sphingolipids comprise a large group of lipid molecules, which function as the building blocks of biological membranes and play important signaling and regulatory roles within cells. The roles of sphingoid bases in neurotoxicity and neurodegeneration have yet to be fully elucidated, as they are complex and multi-faceted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.10.004DOI Listing
December 2018

Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells.

Adv Biol Regul 2019 Jan 17;71:172-182. Epub 2018 Oct 17.

Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA. Electronic address:

Berberine (BBR) is a common nutraceutical consumed by millions worldwide. BBR has many different effects on human health, e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.10.003DOI Listing
January 2019
3 Reads

Diacylglycerol kinases: Relationship to other lipid kinases.

Adv Biol Regul 2019 Jan 28;71:104-110. Epub 2018 Sep 28.

The Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address:

Lipid kinases regulate a wide variety of cellular functions and have emerged as one the most promising targets for drug design. Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PtdOH). Despite the critical role in lipid biosynthesis, both DAG and PtdOH have been shown as bioactive lipids mediating a number of signaling pathways. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183013
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347529PMC
January 2019
19 Reads

Application of induced pluripotent stem cell technology for the investigation of hematological disorders.

Adv Biol Regul 2019 Jan 10;71:19-33. Epub 2018 Oct 10.

Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, Oxford, UK. Electronic address:

Induced pluripotent stem cells (iPSCs) were first described over a decade ago and are currently used in various basic biology and clinical research fields. Recent advances in the field of human iPSCs have opened the way to a better understanding of the biology of human diseases. Disease-specific iPSCs provide an unparalleled opportunity to establish novel human cell-based disease models, with the potential to enhance our understanding of the molecular mechanisms underlying human malignancies, and to accelerate the identification of effective new drugs. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183014
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.10.001DOI Listing
January 2019
5 Reads

The regulation of insulin secretion via phosphoinositide-specific phospholipase Cβ signaling.

Adv Biol Regul 2019 Jan 23;71:10-18. Epub 2018 Sep 23.

School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea. Electronic address:

Phospholipase Cβ (PLCβ) is a membrane-associated enzyme activated by membrane receptors, especially G-protein coupled receptors (GPCRs). It propagates intracellular signaling by mediating phospholipid metabolism and generating key second messengers, such as inositol triphosphate and diacylglycerol, leading to intracellular Ca mobilization and activation of kinases, such as protein kinases C. In pancreatic β-cells, PLCβ-mediated signaling activated by various factors, such as free fatty acids and neuronal and hormonal ligands, has been confirmed as being involved in the regulation of insulin secretion, and PLCβs have been regarded as essential mediators for augmenting insulin secretion. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183014
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.09.011DOI Listing
January 2019
2 Reads

Sphingolipids in neurodegeneration (with focus on ceramide and S1P).

Adv Biol Regul 2018 Dec 22;70:51-64. Epub 2018 Sep 22.

Department of Physiology, University of Kentucky, Lexington, KY, USA. Electronic address:

For many decades, research on sphingolipids associated with neurodegenerative disease focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides), sulfatides, and gangliosides. This seemed quite natural since many of these glycolipids are constituents of myelin and accumulated in lipid storage diseases (sphingolipidoses) resulting from enzyme deficiencies in glycolipid metabolism. With the advent of recognizing ceramide and its derivative, sphingosine-1-phosphate (S1P), as key players in lipid cell signaling and regulation of cell death and survival, research focus shifted toward these two sphingolipids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251739PMC
December 2018
2 Reads

Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism.

Adv Biol Regul 2019 Jan 25;71:128-140. Epub 2018 Sep 25.

UCSF Benioff Children's Hospital Oakland, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA, 94609, USA. Electronic address:

Sphingosine-1-phosphate lyase (SPL) is an intracellular enzyme that controls the final step in the sphingolipid degradative pathway, the only biochemical pathway for removal of sphingolipids. Specifically, SPL catalyzes the cleavage of sphingosine 1-phosphate (S1P) at the C2-3 carbon bond, resulting in its irreversible degradation to phosphoethanolamine (PE) and hexadecenal. The substrate of the reaction, S1P, is a bioactive sphingolipid metabolite that signals through a family of five G protein-coupled S1P receptors (S1PRs) to mediate biological activities including cell migration, cell survival/death/proliferation and cell extrusion, thereby contributing to development, physiological functions and - when improperly regulated - the pathophysiology of disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347531PMC
January 2019
15 Reads

Gle1 mediates stress granule-dependent survival during chemotoxic stress.

Adv Biol Regul 2019 Jan 18;71:156-171. Epub 2018 Sep 18.

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, 37240, USA. Electronic address:

Stress granules (SGs) are non-membrane bound organelles that form in response to multiple different stress stimuli, including exposure to sodium arsenite. SGs are postulated to support cells during periods of stress and provide a protective effect, allowing survival. Gle1 is a highly conserved, essential modulator of RNA-dependent DEAD-box proteins that exists as at least two distinct isoforms in human cells. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183013
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347492PMC
January 2019
19 Reads

Of local translation control and lipid signaling in neurons.

Adv Biol Regul 2019 Jan 15;71:194-205. Epub 2018 Sep 15.

Université de Strasbourg, 67084, Strasbourg, France; Institut des Neurosciences Cellulaires et Intégratives, UPR3212 CNRS, 67084, Strasbourg, France.

Fine-tuned regulation of new proteins synthesis is key to the fast adaptation of cells to their changing environment and their response to external cues. Protein synthesis regulation is particularly refined and important in the case of highly polarized cells like neurons where translation occurs in the subcellular dendritic compartment to produce long-lasting changes that enable the formation, strengthening and weakening of inter-neuronal connection, constituting synaptic plasticity. The changes in local synaptic proteome of neurons underlie several aspects of synaptic plasticity and new protein synthesis is necessary for long-term memory formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.005DOI Listing
January 2019
11 Reads

Nuclear phosphoinositides and phase separation: Important players in nuclear compartmentalization.

Adv Biol Regul 2019 Jan 17;71:111-117. Epub 2018 Sep 17.

Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, v.v.i., 142 20, Prague, Czech Republic; Department of Epigenetics of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, v.v.i., division BIOCEV, 25250, Vestec, Czech Republic; Microscopy Centre, Institute of Molecular Genetics of the Czech Academy of Sciences, v.v.i., 142 20, Prague, Czech Republic. Electronic address:

Nuclear phosphoinositides are recognized as regulators of many nuclear processes including chromatin remodeling, splicing, transcription, DNA repair and epigenetics. These processes are spatially organized in different nuclear compartments. Phase separation is involved in the formation of various nuclear compartments and molecular condensates separated from surrounding environment. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183013
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.09.009DOI Listing
January 2019
1 Read

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update.

Adv Biol Regul 2019 Jan 19;71:88-96. Epub 2018 Sep 19.

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal. Electronic address:

Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration and resistance to chemotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386770PMC
January 2019
22 Reads

Galectins as regulators of cell survival in the leukemia niche.

Authors:
Peter P Ruvolo

Adv Biol Regul 2019 Jan 12;71:41-54. Epub 2018 Sep 12.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address:

The microenvironment within the bone marrow (BM) contains support cells that promote leukemia cell survival and suppress host anti-tumor defenses. Galectins are a family of beta-galactoside binding proteins that are critical components in the tumor microenvironment. Galectin 1 (LGALS1) and Galectin 3 (LGALS3) as regulators of RAS signaling intracellularly and as inhibitors of immune cells extracellularly are perhaps the best studied members for their role in leukemia biology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.003DOI Listing
January 2019
15 Reads

Role of FABP7 in tumor cell signaling.

Adv Biol Regul 2019 Jan 15;71:206-218. Epub 2018 Sep 15.

Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:

Lipids are major molecules for the function of organisms and are involved in the pathophysiology of various diseases. Fatty acids (FAs) signaling and their metabolism are some of the most important pathways in tumor development, as lipids serve as energetic sources during carcinogenesis. Fatty acid binding proteins (FABPs) facilitate FAs transport to different cell organelles, modulating their metabolism along with mediating other physiological activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.006DOI Listing
January 2019
1 Read

Mitogen and stress- activated protein kinase regulated gene expression in cancer cells.

Adv Biol Regul 2019 Jan 17;71:147-155. Epub 2018 Sep 17.

Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, R3E 0J9, Canada. Electronic address:

The mitogen- and stress-activated protein kinases activated by the extracellular-signal-regulated kinase 1/2 and/or stress-activated protein kinase 2/p38 mitogen-activated protein kinase pathways are recruited to the regulatory region of a subset of genes termed immediate-early genes, often leading to their induction. These genes, many of which code for transcription factors, have been directly linked to the phenotypic events in carcinogenesis. In this paper, we focus on the mitogen- and stress-activated protein kinases; their discovery, activation, H3 phosphorylation and recent discoveries in their roles in cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.010DOI Listing
January 2019
1 Read

Regulation of tumor cell - Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis.

Adv Biol Regul 2019 Jan 16;71:183-193. Epub 2018 Sep 16.

Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN, 38163, USA.

The lipid mediator lysophosphatidic acid (LPA) in biological fluids is primarily produced by cleavage of lysophospholipids by the lysophospholipase D enzyme Autotaxin (ATX). LPA has been identified and abundantly detected in the culture medium of various cancer cell types, tumor effusates, and ascites fluid of cancer patients. Our current understanding of the physiological role of LPA established its role in fundamental biological responses that include cell proliferation, metabolism, neuronal differentiation, angiogenesis, cell migration, hematopoiesis, inflammation, immunity, wound healing, regulation of cell excitability, and the promotion of cell survival by protecting against apoptotic death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433480PMC
January 2019
1 Read

Niemann-Pick type C disease: The atypical sphingolipidosis.

Adv Biol Regul 2018 Dec 28;70:82-88. Epub 2018 Aug 28.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA. Electronic address:

Niemann-Pick type C (NPC) disease is a lysosomal storage disorder resulting from mutations in either the NPC1 (95%) or NPC2 (5%) genes. NPC typically presents in childhood with visceral lipid accumulation and complex progressive neurodegeneration characterized by cerebellar ataxia, dysphagia, and dementia, resulting in a shortened lifespan. While cholesterol is widely acknowledged as the principal storage lipid in NPC, multiple species of sphingolipids accumulate as well. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327306PMC
December 2018
3 Reads

Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.

Adv Biol Regul 2019 Jan 5;71:34-40. Epub 2018 Sep 5.

Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address:

Malonyl-CoA is a central metabolite in fatty acid biochemistry. It is the rate-determining intermediate in fatty acid synthesis but is also an allosteric inhibitor of the rate-setting step in mitochondrial long-chain fatty acid oxidation. While these canonical cytoplasmic roles of malonyl-CoA have been well described, malonyl-CoA can also be generated within the mitochondrial matrix by an alternative pathway: the ATP-dependent ligation of malonate to Coenzyme A by the malonyl-CoA synthetase ACSF3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347522PMC
January 2019

Sphingolipids and their enigmatic role in asthma.

Authors:
Jamie L Sturgill

Adv Biol Regul 2018 Dec 5;70:74-81. Epub 2018 Sep 5.

University of Kentucky, Department of Internal Medicine, Division of Pulmonary, Critical Care, & Sleep Medicine, 740 South Limestone St, Lexington, KY 40536, United States. Electronic address:

Asthma is defined as a chronic inflammatory condition in the lung and is characterized by episodic shortness of breath with expiratory wheezing and cough. Asthma is a serious public health concern globally with an estimated incidence over 300 million. Asthma is a complex disease in that it manifests as disease of gene and environmental interactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.001DOI Listing
December 2018

Orm/ORMDL proteins: Gate guardians and master regulators.

Adv Biol Regul 2018 Dec 31;70:3-18. Epub 2018 Aug 31.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address:

Sphingolipids comprise a diverse family of lipids that perform multiple functions in both structure of cellular membranes and intra- and inter-cellular signaling. The diversity of this family is generated by an array of enzymes that produce individual classes and molecular species of family members and enzymes which catabolize those lipids for recycling pathways. However, all of these lipids begin their lives with a single step, the condensation of an amino acid, almost always serine, and a fatty acyl-CoA, almost always the 16-carbon, saturated fatty acid, palmitate. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22124926183012
Publisher Site
http://dx.doi.org/10.1016/j.jbior.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251742PMC
December 2018
15 Reads

Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals.

Adv Biol Regul 2018 Aug 28;69:16-34. Epub 2018 Jun 28.

Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5-10%. Mutations at the TP53 gene are readily detected in pancreatic tumors isolated from PDAC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.06.002DOI Listing
August 2018
1 Read

The regulation of normal and neoplastic hematopoiesis is dependent on microenvironmental cells.

Adv Biol Regul 2018 Aug 27;69:11-15. Epub 2018 Jun 27.

Stony Brook University School of Medicine, Stony Brook, NY, USA.

Each day the adult human produces 4 × 10 red blood cells, 1 × 10 white blood cells and 1 × 10 platelets, levels of production which can increase 10-20 fold in times of heightened demand. Hematopoiesis, or the formation of the ten different types of blood and marrow cells, is a complex process involving hematopoietic stem cells (HSCs), cytokine growth factors and cell surface adhesion molecules, and both specific and ubiquitous transcription factors. The marrow micro-environmental niche is defined as the site at which HSCs reside and are nurtured, receiving the signals that lead to their survival, replication and/or differentiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102082PMC
August 2018
23 Reads

Systematic analysis of GSK-3 signaling pathways in aging of cerebral tissue.

Adv Biol Regul 2018 Aug 21;69:35-42. Epub 2018 Jun 21.

Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland. Electronic address:

Glycogen synthase kinase-3 (GSK-3) is a constitutively active kinase, involved in regulation of multiple physiological processes. In brain, changes in GSK-3 signaling are related to neurodegenerative issues, including Alzheimer's disease. Due to the wide range of GSK-3 cellular targets, a therapeutic use of the enzyme inhibitors entails significant risk of side effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.06.001DOI Listing
August 2018
4 Reads

Roles of p53, NF-κB and the androgen receptor in controlling NGAL expression in prostate cancer cell lines.

Adv Biol Regul 2018 Aug 18;69:43-62. Epub 2018 May 18.

Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA. Electronic address:

Neutrophil gelatinase-associated lipocalin (NGAL a.k.a lipocalin 2, lnc2) is a secreted protein which can form a complex with matrix metalloproteinase-9 (MMP9). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.05.002DOI Listing
August 2018
17 Reads

Nuclear organization mediates cancer-compromised genetic and epigenetic control.

Adv Biol Regul 2018 Aug 9;69:1-10. Epub 2018 May 9.

Department of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States. Electronic address:

Nuclear organization is functionally linked to genetic and epigenetic regulation of gene expression for biological control and is modified in cancer. Nuclear organization supports cell growth and phenotypic properties of normal and cancer cells by facilitating physiologically responsive interactions of chromosomes, genes and regulatory complexes at dynamic three-dimensional microenvironments. We will review nuclear structure/function relationships that include: 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102062PMC
August 2018
5 Reads

Foreword: "Current trends in cancer and signalling".

Authors:
Pann-Ghill Suh

Adv Biol Regul 2018 May 11;68. Epub 2018 Apr 11.

Professor and National Scholar, Director of Center for Cell to Cell Communication in Cancer, School of Life Sciences, Ulsan National Institute of Science and Technology, Eng.Bldg.4 #409, UNIST-gil 50, Ulju-gun, Ulsan, 44919, South Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.04.001DOI Listing

Application of HTLV-1 tax transgenic mice for therapeutic intervention.

Adv Biol Regul 2018 May 13;68:10-12. Epub 2018 Feb 13.

Dept of Pathology, National Institute of Infectious Diseases, 1-23-1 Shinjuku-ku, Tokyo, 162-8640, Japan.

Adult T-cell leukemia-lymphoma (ATL) is a refractory T-cell malignancy caused by infection of human T-cell leukemia virus type I (HTLV-I). Although the pathogenesis of ATL remains unclear, HTLV-1 oncoprotein Tax plays an important role in pathogenesis (Matsuoka, 2003; Jeang et al., 2004). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.02.004DOI Listing
May 2018
22 Reads

Dual inhibition of PI3K/mTOR signaling in chemoresistant AML primary cells.

Adv Biol Regul 2018 May 19;68:2-9. Epub 2018 Mar 19.

Cellular Signaling Unit, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy. Electronic address:

A main cause of treatment failure for AML patients is resistance to chemotherapy. Survival of AML cells may depend on mechanisms that elude conventional drugs action and/or on the presence of leukemia initiating cells at diagnosis, and their persistence after therapy. MDR1 gene is an ATP-dependent drug efflux pump known to be a risk factor for the emergence of resistance, when combined to unstable cytogenetic profile of AML patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.03.001DOI Listing
May 2018
5 Reads

Metformin influences drug sensitivity in pancreatic cancer cells.

Adv Biol Regul 2018 May 12;68:13-30. Epub 2018 Feb 12.

Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5-10% after diagnosis and treatment. Pancreatic cancer has been associated with type II diabetes as the frequency of recently diagnosed diabetics that develop pancreatic cancer within a 10-year period of initial diagnosis of diabetes in increased in comparison to non-diabetic patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.02.002DOI Listing
May 2018
3 Reads

Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.

Adv Biol Regul 2018 May 8;68:31-38. Epub 2018 Feb 8.

University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA. Electronic address:

Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P) that controls essentially all aspects of cellular functions. PI4,5P rapidly diffuses in the membrane of the lipid bilayer and does not greatly change in membrane or cellular content, and thus PI4,5P generation by PIPKs is tightly linked to its usage in subcellular compartments. Based on this verity, recent study of PI4,5P signal transduction has been focused on investigations of individual PIPKs and their underlying molecular regulation of cellular processes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955796PMC
May 2018
3 Reads

Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis.

Adv Biol Regul 2018 May 10;68:46-54. Epub 2018 Jan 10.

Translational Research Center for Protein Function Control, Yonsei University, Seoul, South Korea; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea. Electronic address:

Cancer development is usually driven by multiple genetic and molecular alterations rather than by a single defect. In the human colorectal cancer (CRC), series of mutations of genes are involved in the different stages of tumorigenesis. For example, adenomatous polyposis coli (APC) and KRAS mutations have been known to play roles in the initiation and progression of the tumorigenesis, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.01.001DOI Listing
May 2018
18 Reads