1,076 results match your criteria Advances in biochemical engineering/biotechnology[Journal]


Microfluidics for Environmental Applications.

Adv Biochem Eng Biotechnol 2020 May 22. Epub 2020 May 22.

School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

Microfluidic and lab-on-a-chip systems have become increasingly important tools across many research fields in recent years. As a result of their small size and precise flow control, as well as their ability to enable in situ process visualization, microfluidic systems are increasingly finding applications in environmental science and engineering. Broadly speaking, their main present applications within these fields include use as sensors for water contaminant analysis (e. Read More

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http://dx.doi.org/10.1007/10_2020_128DOI Listing

Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics.

Adv Biochem Eng Biotechnol 2020 May 21. Epub 2020 May 21.

Department of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa, Israel.

The recent coronavirus (COVID-19) pandemic has underscored the need to move from traditional lab-centralized diagnostics to point-of-care (PoC) settings. Lab-on-a-chip (LoC) platforms facilitate the translation to PoC settings via the miniaturization, portability, integration, and automation of multiple assay functions onto a single chip. For this purpose, paper-based assays and microfluidic platforms are currently being extensively studied, and much focus is being directed towards simplifying their design while simultaneously improving multiplexing and automation capabilities. Read More

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http://dx.doi.org/10.1007/10_2020_127DOI Listing

Alkaliphiles: The Versatile Tools in Biotechnology.

Adv Biochem Eng Biotechnol 2020 Apr 28. Epub 2020 Apr 28.

Department of Biotechnology, Lund University, Lund, Sweden.

The extreme environments within the biosphere are inhabited by organisms known as extremophiles. In recent years to Lately, these organisms are attracting a great deal of interest from researchers and industrialists. The motive behind this attraction is mainly related to the desire for new and efficient products of biotechnological importance and human curiosity of understanding nature. Read More

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http://dx.doi.org/10.1007/10_2020_126DOI Listing

Impedimetric Aptamer-Based Biosensors: Principles and Techniques.

Adv Biochem Eng Biotechnol 2020 Apr 24. Epub 2020 Apr 24.

Institute of Technical Chemistry, Leibniz Universität Hannover, Hanover, Germany.

Aptamers are a specific class of ligands with high affinities comparable to antibodies, which are selected and synthesized in vitro. In combination with impedance spectroscopy as sensitive measurement method, we gain a class of biosensors with high potential for handheld devices and point-of-care tests. In this review, we report on recent advances in aptamer-based impedimetric biosensors. Read More

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http://dx.doi.org/10.1007/10_2019_113DOI Listing

Correction to: Animal Cell Expression Systems.

Authors:
M Butler U Reichl

Adv Biochem Eng Biotechnol 2020 Apr 20. Epub 2020 Apr 20.

Lehrstuhl für Bioprozesstechnik, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany.

On page 3, as per the author's request the current list of abbreviations is replaced with complete list of abbreviations. Read More

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http://dx.doi.org/10.1007/10_2020_121DOI Listing

Impedimetric Aptamer-Based Biosensors: Applications.

Adv Biochem Eng Biotechnol 2020 Apr 21. Epub 2020 Apr 21.

Institute of Technical Chemistry, Leibniz Universität Hannover, Hannover, Germany.

Impedimetric aptamer-based biosensors show high potential for handheld devices and point-of-care tests. In this review, we report on recent advances in aptamer-based impedimetric biosensors for applications in biotechnology. We detail on analytes relevant in medical and environmental biotechnology as well as food control, for which aptamer-based impedimetric biosensors were developed. Read More

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http://dx.doi.org/10.1007/10_2020_125DOI Listing

The Sustainability and Life Cycle Assessments of Industrial Biotechnology: An Introduction.

Adv Biochem Eng Biotechnol 2020 Mar 31. Epub 2020 Mar 31.

Ulm University, Department of Business Chemistry, Ulm, Germany.

Industrial biotechnology (IB) uses biological and biochemical processes in industrial production and is often regarded as an emerging key technology revolutionizing the production of many products while protecting resources and the environment and fostering economic development. This contribution describes the background and sketches the content of the volume 'Sustainability and Life Cycle Assessment of Industrial Biotechnology' in the Springer series 'Advances in Biochemical Engineering/Biotechnology'. The field of IB is introduced from different perspectives (milestones in IB history, economics of biotechnology industry, environmental and social as well as ethical issues and impacts, green chemistry) and in several applications fields (production of chemicals, geobiotechnology in mining). Read More

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http://dx.doi.org/10.1007/10_2020_123DOI Listing

Sustainability and Life Cycle Assessment in Industrial Biotechnology: A Review of Current Approaches and Future Needs.

Adv Biochem Eng Biotechnol 2020 Mar 30. Epub 2020 Mar 30.

Ulm University, Department of Business Chemistry, Ulm, Germany.

The development and implementation of industrial biotechnology (IB) is associated with high expectations for reductions of environmental impacts and risks, particularly in terms of climate change and fossil resource depletion, positive socioeconomic effects, hopes for new competitive products and processes, and development in rural areas. However, not all products and processes are really advantageous with regard to sustainability criteria, and not all are economically successful and accepted by stakeholders. Sustainability and life cycle assessment can play an important role to assess IB products and processes, often accompanying development processes from the early stages onwards. Read More

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http://dx.doi.org/10.1007/10_2020_122DOI Listing

Aptamer-Modified Nanoparticles in Medical Applications.

Adv Biochem Eng Biotechnol 2020 Mar 11. Epub 2020 Mar 11.

Institut für Technische Chemie, Hannover, Germany.

Since aptamers have been selected against a broad range of target structures of medical interest and nanoparticles are available with diverse properties, aptamer-modified nanoparticles can be used in various diagnostic and therapeutic applications. While the aptamer is responsible for specificity and affinity of the conjugate, the nanoparticles' function varies from signal generation in diagnostic approaches to drug loading in drug delivery systems. Within this chapter different medical applications of aptamer-modified nanoparticles will be summarized and underlying principles will be described. Read More

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http://dx.doi.org/10.1007/10_2020_124DOI Listing

Glycan Array Technology.

Adv Biochem Eng Biotechnol 2020 Jan 7. Epub 2020 Jan 7.

School of Chemistry and MIB, The University of Manchester, Manchester, UK.

Glycan (or carbohydrate) arrays have become an essential tool in glycomics, providing fast and high-throughput data on protein-carbohydrate interactions with small amounts of carbohydrate ligands. The general concepts of glycan arrays have been adopted from other microarray technologies such as those used for nucleic acid and proteins. However, carbohydrates have presented their own challenges, in particular in terms of access to glycan probes, linker attachment chemistries and analysis, which will be reviewed in this chapter. Read More

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http://dx.doi.org/10.1007/10_2019_112DOI Listing
January 2020

Aptamers in Diagnostic and Molecular Imaging Applications.

Authors:
Victoria Calzada

Adv Biochem Eng Biotechnol 2019 Dec 18. Epub 2019 Dec 18.

Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.

The origin of the term diagnostic comes from the Greek word gnosis, meaning "to know." In medicine, a diagnostic can predict the pathology risk, disease status, treatment, and prognosis, even following therapy. An early and correct diagnosis is necessary for an efficient treatment. Read More

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http://dx.doi.org/10.1007/10_2019_115DOI Listing
December 2019

Industrial Challenges of Recombinant Proteins.

Adv Biochem Eng Biotechnol 2020 ;171:1-22

Purdue University Laboratory of Renewable Resource Engineering, West Lafayette, IN, USA.

The use of recombinant DNA methods to produce large quantities of protein for therapeutic uses has revolutionized medicine. Industrial challenges for manufacture of biotherapeutic proteins are related to the characteristics of these proteins and the increasing quantities required to address needs of patients, worldwide. A brief overview of therapies in which proteins are employed helps to frame some of the challenges facing their industrial production. Read More

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http://dx.doi.org/10.1007/10_2019_120DOI Listing
February 2020

Insights on the Formulation of Recombinant Proteins.

Adv Biochem Eng Biotechnol 2020 ;171:23-54

CNC - Center for Neuroscience and Cell Biology, Faculty of Medicine (Pólo I), University of Coimbra, Coimbra, Portugal.

Recombinant proteins are large and complex molecules, whose therapeutic activity highly depends on their structure. Formulation of biopharmaceuticals aims at stabilizing protein conformation, promoting its efficacy, and preventing safety concerns, such as immunogenicity. Currently, the rational design of formulations is possible due to the availability of several techniques for molecule characterization and an array of both well-known and new excipients. Read More

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http://dx.doi.org/10.1007/10_2019_119DOI Listing
February 2020
1.657 Impact Factor

Addressing the Manufacturing Challenges of Cell-Based Therapies.

Adv Biochem Eng Biotechnol 2020 ;171:225-278

Department of Bioengineering and iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.

Exciting developments in the cell therapy field over the last decades have led to an increasing number of clinical trials and the first cell products receiving marketing authorization. In spite of substantial progress in the field, manufacturing of cell-based therapies presents multiple challenges that need to be addressed in order to assure the development of safe, efficacious, and cost-effective cell therapies.The manufacturing process of cell-based therapies generally requires tissue collection, cell isolation, culture and expansion (upstream processing), cell harvest, separation and purification (downstream processing), and, finally, product formulation and storage. Read More

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http://dx.doi.org/10.1007/10_2019_118DOI Listing
February 2020

Assessing Land Use and Biodiversity Impacts of Industrial Biotechnology.

Adv Biochem Eng Biotechnol 2019 Dec 9. Epub 2019 Dec 9.

Department of Life Cycle Engineering, Fraunhofer IBP, Stuttgart, Germany.

One of the many promises of biotechnology is that it allows societies to move away from a fossil-based industry toward a bio-based industry, with positive implications for anthropogenic climate change and resource dependency. The provision of biomass from agriculture or forestry is, however, linked to specific environmental implications that cannot be disregarded in an informed discussion about the role of biotechnology in the twenty-first century. In this chapter, we discuss landuse-related effects of biomass provision such as landscape homogenization, eutrophication, erosion, biodiversity, and others. Read More

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http://dx.doi.org/10.1007/10_2019_114DOI Listing
December 2019

Therapeutic Antibody Engineering and Selection Strategies.

Adv Biochem Eng Biotechnol 2020 ;171:55-86

iMed - Research Institute for Medicines, Faculty of Pharmacy at University of Lisbon, Lisbon, Portugal.

Antibody drugs became an increasingly important element of the therapeutic landscape. Their accomplishment has been driven by many unique properties, in particular by their very high specificity and selectivity, in contrast to the off-target liabilities of small molecules (SMs). Antibodies can bring additional functionality to the table with their ability to interact with the immune system, and this can be further manipulated with advances in antibody engineering. Read More

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http://dx.doi.org/10.1007/10_2019_116DOI Listing
February 2020

Human Pluripotent Stem Cells: Applications and Challenges for Regenerative Medicine and Disease Modeling.

Adv Biochem Eng Biotechnol 2020 ;171:189-224

iBB - Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

In recent years, human pluripotent stem (hPS) cells have started to emerge as a potential tool with application in fields such as regenerative medicine, disease modeling, and drug screening. In particular, the ability to differentiate human-induced pluripotent stem (hiPS) cells into different cell types and to mimic structures and functions of a specific target organ, resourcing to organoid technology, has introduced novel model systems for disease recapitulation while offering a powerful tool to provide a faster and reproducible approach in the process of drug discovery. All these technologies are expected to improve the overall quality of life of the humankind. Read More

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http://dx.doi.org/10.1007/10_2019_117DOI Listing
February 2020

Hormones, Blood Products, and Therapeutic Enzymes.

Adv Biochem Eng Biotechnol 2020 ;171:115-153

UCIBIO, REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Therapeutic uses of biological medicines are diverse and include active substances from different classes. This chapter provides an overview on the clinical applications of biological medicines containing hormones, blood products, and therapeutic enzymes. Currently, therapeutic hormones have 78 approved medicines, including insulin and analogs, glucagon and analogs, growth hormone, gonadotropins (follicle-stimulating hormone, luteinizing hormone, and human chorionic gonadotropin), thyroid-stimulating hormone, and parathyroid hormone. Read More

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http://dx.doi.org/10.1007/10_2019_111DOI Listing
February 2020
1.657 Impact Factor

Gene Therapy.

Adv Biochem Eng Biotechnol 2020 ;171:321-368

Pharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Centro de investigación Lascaray ikergunea, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.

Gene therapy medicinal products (GTMPs) are one of the most promising biopharmaceuticals, which are beginning to show encouraging results. The broad clinical research activity has been addressed mainly to cancer, primarily to those cancers that do not respond well to conventional treatment. GTMPs to treat rare disorders caused by single-gene mutations have also made important advancements toward market availability, with eye and hematopoietic system diseases as the main applications. Read More

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http://dx.doi.org/10.1007/10_2019_109DOI Listing
February 2020

The Impact of Pharmacogenomics in Personalized Medicine.

Authors:
Dev Bukhsh Singh

Adv Biochem Eng Biotechnol 2020 ;171:369-394

Department of Biotechnology, Institute of Biosciences and Biotechnology, Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India.

Recent advances in Pharmacogenomics have made it possible to understand the reasons behind the different response of a drug. Discovery of genetic variants and its association with the varying response of drug provide the basis for recommending a drug and its dose to an individual patient. Genetic makeup-based prescription, design, and implementation of therapy not only improve the outcome of treatments but also reduce the risk of toxicity and other adverse effects. Read More

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http://dx.doi.org/10.1007/10_2019_110DOI Listing
February 2020
5 Reads
1.657 Impact Factor

Aptamer-Based Affinity Chromatography for Protein Extraction and Purification.

Adv Biochem Eng Biotechnol 2019 Sep 5. Epub 2019 Sep 5.

JAM Conseil, Neuilly-sur-Seine, France.

Aptamers are oligonucleotide molecules able to recognize very specifically proteins. Among the possible applications, aptamers have been used for affinity chromatography with effective results and advantages over most advanced protein separation technologies. This chapter first discusses the context of the affinity chromatography with aptamer ligands. Read More

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http://dx.doi.org/10.1007/10_2019_106DOI Listing
September 2019

Bioprinting Technologies in Tissue Engineering.

Adv Biochem Eng Biotechnol 2020 ;171:279-319

Institute of Health Sciences, Department of Tissue Engineering, University of Health Sciences, Istanbul, Turkey.

Bioprinting technology is a strong tool in producing living functional tissues and organs from cells, biomaterial-based bioinks, and growth factors in computer-controlled platform. The aim of this chapter is to present recent progresses in bioprinting of nerve, skin, cardiac, bone, cartilage, skeletal muscle, and other soft tissues and highlight the challenges in these applications. Various composite bioinks with bioactive ceramic-based scaffolds having patient-specific design and controlled micro-architectures were used at clinical and preclinical applications successfully for regeneration of bone. Read More

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http://dx.doi.org/10.1007/10_2019_108DOI Listing
February 2020
2 Reads

Advances in Vaccines.

Adv Biochem Eng Biotechnol 2020 ;171:155-188

CanSino Biologics Inc., Tianjin, China.

Vaccines represent one of the most important advances in science and medicine, helping people around the world in preventing the spread of infectious diseases. However, there are still gaps in vaccination programs in many countries. Out of 11. Read More

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http://link.springer.com/10.1007/10_2019_107
Publisher Site
http://dx.doi.org/10.1007/10_2019_107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120466PMC
February 2020
10 Reads

Environmental Aspects of Biotechnology.

Adv Biochem Eng Biotechnol 2019 Aug 9. Epub 2019 Aug 9.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada.

A key motivation behind the development and adoption of industrial biotechnology is the reduction of negative environmental impacts. However, accurately assessing these impacts remains a formidable task. Environmental impacts of industrial biotechnology may be significant across a number of categories that include, but may not be limited to, nonrenewable resource depletion, water withdrawals and consumption, climate change, and natural land transformation/occupation. Read More

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http://dx.doi.org/10.1007/10_2019_98DOI Listing
August 2019
1 Read

Cytokines and Growth Factors.

Adv Biochem Eng Biotechnol 2020 ;171:87-113

UCIBIO/REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Several cytokines have been used to treat autoimmune diseases, viral infections, and cancer and to regenerate the skin. In particular, interferons (INFs) have been used to treat cancer, hepatitis B and C, and multiple sclerosis, while interleukins (ILs) and tumor necrosis factors (TNFs) have been used in the management of different types of cancer. Concerning the hematopoietic growth factors (HGFs), epoetin has been used for anemia, whereas the colony-stimulating factors (CSFs) have been used for neutropenia. Read More

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http://dx.doi.org/10.1007/10_2019_105DOI Listing
February 2020
2 Reads

Biophysical Characterization of Aptamer-Target Interactions.

Adv Biochem Eng Biotechnol 2019 Aug 3. Epub 2019 Aug 3.

2bind GmbH, Regensburg, Germany.

Aptamers are single-stranded nucleic acid molecules forming well-defined 3D structures. Aptamers typically bind to their ligands with high affinity and specificity. They are capable of interacting with various kinds of ligands: ions, small molecules, peptides, proteins, viruses, bacteria, and even cells. Read More

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http://dx.doi.org/10.1007/10_2019_103DOI Listing

Assessing Industrial Biotechnology Products with LCA and Eco-Efficiency.

Authors:
Peter Saling

Adv Biochem Eng Biotechnol 2019 Aug 2. Epub 2019 Aug 2.

BASF SE, Sustainability Strategy, Ludwigshafen, Germany.

Biotechnology is applied in many industrial areas and uses microorganisms, enzymes, or precursors replacing chemicals to produce goods, including chemicals, plastics, food, agricultural and pharmaceutical products, and energy carriers from renewable raw materials and increasingly also from waste from agriculture and forestry (BIOPRO Baden-Württemberg GmbH, Facts and Figures. Biotechnologie.de. Read More

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http://dx.doi.org/10.1007/10_2019_102DOI Listing

Alkaline Active Hemicellulases.

Authors:
Gashaw Mamo

Adv Biochem Eng Biotechnol 2019 Aug 2. Epub 2019 Aug 2.

Indienz AB, Billeberga, Sweden.

Xylan and mannan are the two most abundant hemicelluloses, and enzymes that modify these polysaccharides are prominent hemicellulases with immense biotechnological importance. Among these enzymes, xylanases and mannanases which play the vital role in the hydrolysis of xylan and mannan, respectively, attracted a great deal of interest. These hemicellulases have got applications in food, feed, bioethanol, pulp and paper, chemical, and beverage producing industries as well as in biorefineries and environmental biotechnology. Read More

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http://dx.doi.org/10.1007/10_2019_101DOI Listing
August 2019
8 Reads

Defining Target Product Profiles (TPPs) for Aptamer-Based Diagnostics.

Adv Biochem Eng Biotechnol 2019 Jul 23. Epub 2019 Jul 23.

Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, India.

Defining target product profiles (TPPs) for aptamer-based diagnostics is crucial to the success or failure of aptamer businesses or products. A well-conceived TPP will place the aptamer in an assay for a target against which antibodies are ill-suited or have difficulty detecting the analyte, such as some highly related proteins or poorly immunogenic small molecule haptens. Strong TPPs can also take advantage of the unique nucleic acid nature of aptamers, to produce assays with longer shelf life or special chemical properties and ability to be modified versus protein-based antibodies. Read More

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http://dx.doi.org/10.1007/10_2019_104DOI Listing

Societal and Ethical Issues in Industrial Biotechnology.

Adv Biochem Eng Biotechnol 2019 Jul 22. Epub 2019 Jul 22.

Biotechnology and Society Group, Delft University of Technology, Delft, The Netherlands.

In this chapter we aim to give an overview of the main societal and ethical issues that are currently voiced around industrial biotechnology. We will illustrate this with some recent cases, such as the development of synthetic artemisinin, synthetic vanillin and vegetable oil produced by engineered algae. We show that current societal and ethical issues in industrial biotechnology centre on the following five themes: sustainability, naturalness, innovation trajectories, risk management and economic justice. Read More

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http://dx.doi.org/10.1007/10_2019_100DOI Listing

Challenges and Adaptations of Life in Alkaline Habitats.

Authors:
Gashaw Mamo

Adv Biochem Eng Biotechnol 2019 Jul 5. Epub 2019 Jul 5.

Indienz AB, Billeberga, Sweden.

A vast array of organisms is known thriving in high pH environments. The biotechnological, medical, and environmental importance of this remarkable group of organisms has attracted a great deal of interest among researchers and industrialists. One of the most intriguing phenomena of alkaliphiles that engrossed researchers' attention is their adaptation to high pH and ability to thrive in the "extreme" condition which is often lethal to other organisms. Read More

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http://dx.doi.org/10.1007/10_2019_97DOI Listing

Metabolites Produced by Alkaliphiles with Potential Biotechnological Applications.

Adv Biochem Eng Biotechnol 2019 Jun 26. Epub 2019 Jun 26.

Department of Future Technologies, University of Turku, Turku, Finland.

Alkaliphiles are a diverse group of relatively less known microorganisms living in alkaline environments. To thrive in alkaline environments, alkaliphiles require special adaptations. This adaptation may have evolved metabolites which can be useful for biotechnological processes or other applications. Read More

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http://dx.doi.org/10.1007/10_2019_96DOI Listing
June 2019
3 Reads

Social Life Cycle Assessment for Industrial Biotechnology.

Adv Biochem Eng Biotechnol 2019 Jun 6. Epub 2019 Jun 6.

ITAP, University of Montpellier, IRSTEA, Montpellier SupAgro, Montpellier, France.

This chapter focuses on social assessment methods (known as SLCA) applied to industrial biotechnology (IB), which are part of the "life cycle" approach. IB is a heading for a set of different technologies. The first section presents a review of the literature to provide an analysis of the results and limitations of IB SLCA studies, with the main focus on the biofuel industries. Read More

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http://dx.doi.org/10.1007/10_2019_99DOI Listing
June 2019
2 Reads

Alkaliphilic Enzymes and Their Application in Novel Leather Processing Technology for Next-Generation Tanneries.

Adv Biochem Eng Biotechnol 2019 May 3. Epub 2019 May 3.

Department of Biochemistry, College of Health Sciences, University of Nairobi, Nairobi, Kenya.

Leather manufacturing involves conversion of raw skin and hides into leather (stable material) through series of mechanical and chemical operations. The leather industry has attracted public outcry due to severe environmental degradation, pollution and health and safety risks. Currently the industry faces serious sustainability challenge due to extensive use of toxic chemicals and generation of hazardous waste. Read More

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http://dx.doi.org/10.1007/10_2019_95DOI Listing
May 2019
3 Reads

Alkaliphiles: The Emerging Biological Tools Enhancing Concrete Durability.

Adv Biochem Eng Biotechnol 2019 May 1. Epub 2019 May 1.

Department of Biotechnology, Lund University, Lund, Sweden.

Concrete is one of the most commonly used building materials ever used. Despite it is a very important and common construction material, concrete is very sensitive to crack formation and requires repair. A variety of chemical-based techniques and materials have been developed to repair concrete cracks. Read More

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http://dx.doi.org/10.1007/10_2019_94DOI Listing
May 2019
3 Reads

Starch-Modifying Enzymes.

Adv Biochem Eng Biotechnol 2019 Apr 2. Epub 2019 Apr 2.

Department of Biochemistry and Biotechnology, Pwani University, Kilifi, Kenya.

Starch is a carbohydrate polymer found abundantly on earth. It is synthesized in plants as a short-term storage compound for respiration in the leaves and for long-term storage in the tubers, seeds and roots of plants. A wide variety of enzymes modify or convert starch into various products. Read More

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http://dx.doi.org/10.1007/10_2019_91DOI Listing
April 2019
4 Reads

Stimulating Production of Pigment-Type Secondary Metabolites from Soft Rotting Wood Decay Fungi ("Spalting" Fungi).

Adv Biochem Eng Biotechnol 2019 ;169:109-124

Wood Science & Engineering, Oregon State University, Corvallis, OR, USA.

A small group of soft rotting wood decay fungi produce extracellular pigments as secondary metabolites in response to stress and as a means of resource capture. These fungi are collectively known as "spalting fungi" and have been used in wood art for centuries. The pigments produced by these fungi are finding increasing usage in industrial dye applications and green energy but remain problematic to grow in batch culture. Read More

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http://dx.doi.org/10.1007/10_2019_93DOI Listing
July 2019
2 Reads

Aptazymes: Expanding the Specificity of Natural Catalytic Nucleic Acids by Application of In Vitro Selected Oligonucleotides.

Adv Biochem Eng Biotechnol 2020 ;170:107-119

Institute for Technical Chemistry, Leibniz University Hanover, Hannover, Germany.

Aptazymes are synthetic molecules composed of an aptamer domain and a catalytic active nucleic acid unit, which may be a ribozyme or a DNAzyme. In these constructs the aptamer domain serves as a molecular switch that can regulate the catalytic activity of the ribozyme or DNAzyme subunit. This regulation is triggered by binding of the aptamers target molecule, which causes significant structural changes in the aptamer and thus in the entire aptazyme. Read More

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http://dx.doi.org/10.1007/10_2019_92DOI Listing
October 2019
3 Reads

Cultivation of Medicinal Mushroom Biomass by Solid-State Bioprocessing in Bioreactors.

Authors:
Marin Berovic

Adv Biochem Eng Biotechnol 2019 ;169:3-25

Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.

Basidiomycetes of various species and their wide range of pharmaceutically interesting products in the last decades represent one of the most attractive groups of natural products in Asia and North America. Production of fungal fruit bodies using farming technology is hardly covering the market. Comprehensive solid-state technologies and bioreactors are the most promising part for fast and large amount of cultivation of medicinal fungi biomass and its pharmaceutically active products. Read More

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http://dx.doi.org/10.1007/10_2019_89DOI Listing
July 2019
4 Reads

Design and Operation of a Pilot-Scale Packed-Bed Bioreactor for the Production of Enzymes by Solid-State Fermentation.

Adv Biochem Eng Biotechnol 2019 ;169:27-50

Departamento de Química, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

In this review, we describe our experience in building a pilot-scale packed-bed solid-state fermentation (SSF) bioreactor, with provision for intermittent mixing, and the use of this bioreactor to produce pectinases and lipases by filamentous fungi. We show that, at pilot scale, special attention must be given to several aspects that are not usually problematic when one works with laboratory-scale SSF bioreactors. For example, it can be a challenge to produce large amounts of inoculum if the fungus does not sporulate well. Read More

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http://dx.doi.org/10.1007/10_2019_90DOI Listing
July 2019
3 Reads

Aroma Profile Analyses of Filamentous Fungi Cultivated on Solid Substrates.

Adv Biochem Eng Biotechnol 2019 ;169:85-107

Justus Liebig University Giessen, Institute of Food Chemistry and Food Biotechnology, Giessen, Germany.

Filamentous fungi have been used since centuries in the production of food by means of solid substrate fermentation (SSF). The most applied SSF involving fungi is the cultivation of mushrooms, e.g. Read More

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http://dx.doi.org/10.1007/10_2019_87DOI Listing
July 2019
4 Reads

It Is the Mix that Matters: Substrate-Specific Enzyme Production from Filamentous Fungi and Bacteria Through Solid-State Fermentation.

Adv Biochem Eng Biotechnol 2019 ;169:51-81

Institut für Naturstofftechnik, Professur für Bioverfahrenstechnik, Technische Universität Dresden, Dresden, Germany.

Fungi have a diverse spectrum of extracellular enzymes. In nature, extracellular enzymes primarily serve to procure nutrients for the survival and growth of the fungi. Complex polymers such as lignocellulose and starch as well as proteins and fats are broken down into their basic building blocks by extracellular enzymes such as amylases, proteases, lipases, xylanases, laccases, and many more. Read More

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http://dx.doi.org/10.1007/10_2019_85DOI Listing
July 2019
2 Reads

Isolation and Cultivation of Alkaliphiles.

Authors:
Vadim V Kevbrin

Adv Biochem Eng Biotechnol 2019 Feb 23. Epub 2019 Feb 23.

Winogradsky Institute of Microbiology, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia.

Alkaliphilic microorganisms are ubiquitous and inhabit various econiches on Earth. Alkaline environments suitable for alkaliphilic microbial communities may be created by certain geological processes or human activities. Moreover, a significant contribution to the emergence of alkaline conditions may be due to the activity of neutralophilic microorganisms through certain reactions, which explains the widespread distribution of alkaliphiles. Read More

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http://dx.doi.org/10.1007/10_2018_84DOI Listing
February 2019
3 Reads

Genomics of Alkaliphiles.

Adv Biochem Eng Biotechnol 2019 Feb 23. Epub 2019 Feb 23.

Centre for Microbial Ecology and Genomics, Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.

Alkalinicity presents a challenge for life due to a "reversed" proton gradient that is unfavourable to many bioenergetic processes across the membranes of microorganisms. Despite this, many bacteria, archaea, and eukaryotes, collectively termed alkaliphiles, are adapted to life in alkaline ecosystems and are of great scientific and biotechnological interest due to their niche specialization and ability to produce highly stable enzymes. Advances in next-generation sequencing technologies have propelled not only the genomic characterization of many alkaliphilic microorganisms that have been isolated from nature alkaline sources but also our understanding of the functional relationships between different taxa in microbial communities living in these ecosystems. Read More

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http://dx.doi.org/10.1007/10_2018_83DOI Listing
February 2019
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Solid-State Anaerobic Digestion for Waste Management and Biogas Production.

Adv Biochem Eng Biotechnol 2019 ;169:147-168

Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, USA.

Solid-state anaerobic digestion (SS-AD) is commonly used to treat feedstocks with high solid content such as municipal solid waste and lignocellulosic biomass. Compared to liquid state anaerobic digestion (LS-AD), SS-AD has multiple advantages including high organic loading, minimal digestate generated, and low energy requirement for heating. However, the main disadvantages limiting the efficiency of SS-AD are long solid retention time, incomplete mixing, and an accumulation of inhibitors. Read More

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http://dx.doi.org/10.1007/10_2019_86DOI Listing
July 2019
6 Reads

Fermented Solids and Their Application in the Production of Organic Compounds of Biotechnological Interest.

Adv Biochem Eng Biotechnol 2019 ;169:125-146

Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

We review the application of dry fermented solids (DFS) containing naturally immobilized enzymes as catalysts in synthesis and in hydrolysis reactions. The most studied application is the use of DFS containing lipases in the synthesis of biodiesel esters, by transesterification of oils or by esterification of fatty acids with short-chain alcohols in solvent-free reaction media. Other applications of DFS that have been studied include the use of DFS containing pectinases to liberate D-galacturonic acid from pectin and the production of high-value compounds by DFS containing lipases, such as the synthesis of sugar esters and the production of pure enantiomers by resolution of racemic mixtures. Read More

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http://dx.doi.org/10.1007/10_2019_88DOI Listing
July 2019
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Application Potentials of Geobiotechnology in Mining, Mineral Processing, and Metal Recycling.

Adv Biochem Eng Biotechnol 2019 Feb 19. Epub 2019 Feb 19.

G.E.O.S. Ingenieurgesellschaft mbH, Halsbrücke, Germany.

This chapter highlights the huge and manifold possibilities of reactions which result from the interactions between microorganisms and the geosphere and which are used for mining, mineral processing, and metal recycling. Besides the introduction (Sect. 1) the contribution is divided into five different sections describing the mobilization (Sect. Read More

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http://dx.doi.org/10.1007/10_2018_82DOI Listing
February 2019
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Environmental Concerns Regarding Ionic Liquids in Biotechnological Applications.

Adv Biochem Eng Biotechnol 2019 ;168:241-328

School of Chemical Engineering, Chonbuk National University, Jeonju, South Korea.

Ionic liquids provide challenges and opportunities for sustainable industrial developments. However, the toxic impacts of ionic liquids reported by many researchers cannot be overlooked. Therefore, in this chapter, we introduce the antimicrobial activities of ionic liquids in bioprocesses and, in greater detail, we discuss their environmental impacts, including the toxicity, biodegradability, bioaccumulation, and mobility of ionic liquids. Read More

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http://dx.doi.org/10.1007/10_2018_79DOI Listing
July 2019
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History, Current State, and Emerging Applications of Industrial Biotechnology.

Adv Biochem Eng Biotechnol 2019 Jan 23. Epub 2019 Jan 23.

DECHEMA - Gesellschaft für Chemische Technik und Biotechnologie e.V, Frankfurt am Main, Germany.

The past 150 years have seen remarkable discoveries, rapidly growing biological knowledge, and giant technological leaps providing biotechnological solutions for healthcare, food production, and other societal needs. Genetic engineering, miniaturization, and ever-increasing computing power, in particular, have been key technological drivers for the past few decades. Looking ahead, the eventual transition from fossil resources to biomass and CO demands a shift toward a 'bio-economy' based on novel production processes and engineered organisms. Read More

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http://dx.doi.org/10.1007/10_2018_81DOI Listing
January 2019
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Whole-Cell Biocatalysis in Ionic Liquids.

Adv Biochem Eng Biotechnol 2019 ;168:105-132

Department of Biological Engineering, Inha University, Incheon, South Korea.

The use of whole-cell biocatalysis in ionic liquid (IL)-containing systems has attracted increasing attention in recent years. Compared to bioreactions catalyzed by isolated enzymes, the major advantage of using whole cells in biocatalytic processes is that the cells provide a natural intracellular environment for the enzymes to function with in situ cofactor regeneration. To date, the applications of whole-cell biocatalysis in IL-containing systems have focused on the production of valuable compounds, mainly through reduction, oxidation, hydrolysis, and transesterification reactions. Read More

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http://dx.doi.org/10.1007/10_2018_77DOI Listing
July 2019
5 Reads