1,041 results match your criteria Advances in biochemical engineering/biotechnology[Journal]


Starch-Modifying Enzymes.

Adv Biochem Eng Biotechnol 2019 Apr 2. Epub 2019 Apr 2.

Department of Biochemistry and Biotechnology, Pwani University, Kilifi, Kenya.

Starch is a carbohydrate polymer found abundantly on earth. It is synthesized in plants as a short-term storage compound for respiration in the leaves and for long-term storage in the tubers, seeds and roots of plants. A wide variety of enzymes modify or convert starch into various products. Read More

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http://dx.doi.org/10.1007/10_2019_91DOI Listing
April 2019
1 Read

Stimulating Production of Pigment-Type Secondary Metabolites from Soft Rotting Wood Decay Fungi ("Spalting" Fungi).

Adv Biochem Eng Biotechnol 2019 Mar 20. Epub 2019 Mar 20.

Wood Science & Engineering, Oregon State University, Corvallis, OR, USA.

A small group of soft rotting wood decay fungi produce extracellular pigments as secondary metabolites in response to stress and as a means of resource capture. These fungi are collectively known as "spalting fungi" and have been used in wood art for centuries. The pigments produced by these fungi are finding increasing usage in industrial dye applications and green energy but remain problematic to grow in batch culture. Read More

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http://dx.doi.org/10.1007/10_2019_93DOI Listing

Aptazymes: Expanding the Specificity of Natural Catalytic Nucleic Acids by Application of In Vitro Selected Oligonucleotides.

Adv Biochem Eng Biotechnol 2019 Mar 8. Epub 2019 Mar 8.

Institute for Technical Chemistry, Leibniz University Hanover, Hannover, Germany.

Aptazymes are synthetic molecules composed of an aptamer domain and a catalytic active nucleic acid unit, which may be a ribozyme or a DNAzyme. In these constructs the aptamer domain serves as a molecular switch that can regulate the catalytic activity of the ribozyme or DNAzyme subunit. This regulation is triggered by binding of the aptamers target molecule, which causes significant structural changes in the aptamer and thus in the entire aptazyme. Read More

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http://dx.doi.org/10.1007/10_2019_92DOI Listing
March 2019
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Cultivation of Medicinal Mushroom Biomass by Solid-State Bioprocessing in Bioreactors.

Authors:
Marin Berovic

Adv Biochem Eng Biotechnol 2019 Mar 4. Epub 2019 Mar 4.

Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.

Basidiomycetes of various species and their wide range of pharmaceutically interesting products in the last decades represent one of the most attractive groups of natural products in Asia and North America. Production of fungal fruit bodies using farming technology is hardly covering the market. Comprehensive solid-state technologies and bioreactors are the most promising part for fast and large amount of cultivation of medicinal fungi biomass and its pharmaceutically active products. Read More

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http://dx.doi.org/10.1007/10_2019_89DOI Listing
March 2019
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Design and Operation of a Pilot-Scale Packed-Bed Bioreactor for the Production of Enzymes by Solid-State Fermentation.

Adv Biochem Eng Biotechnol 2019 Mar 4. Epub 2019 Mar 4.

Departamento de Química, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

In this review, we describe our experience in building a pilot-scale packed-bed solid-state fermentation (SSF) bioreactor, with provision for intermittent mixing, and the use of this bioreactor to produce pectinases and lipases by filamentous fungi. We show that, at pilot scale, special attention must be given to several aspects that are not usually problematic when one works with laboratory-scale SSF bioreactors. For example, it can be a challenge to produce large amounts of inoculum if the fungus does not sporulate well. Read More

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http://dx.doi.org/10.1007/10_2019_90DOI Listing
March 2019
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Aroma Profile Analyses of Filamentous Fungi Cultivated on Solid Substrates.

Adv Biochem Eng Biotechnol 2019 Mar 4. Epub 2019 Mar 4.

Justus Liebig University Giessen, Institute of Food Chemistry and Food Biotechnology, Giessen, Germany.

Filamentous fungi have been used since centuries in the production of food by means of solid substrate fermentation (SSF). The most applied SSF involving fungi is the cultivation of mushrooms, e.g. Read More

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http://dx.doi.org/10.1007/10_2019_87DOI Listing

It Is the Mix that Matters: Substrate-Specific Enzyme Production from Filamentous Fungi and Bacteria Through Solid-State Fermentation.

Adv Biochem Eng Biotechnol 2019 Feb 23. Epub 2019 Feb 23.

Institut für Naturstofftechnik, Professur für Bioverfahrenstechnik, Technische Universität Dresden, Dresden, Germany.

Fungi have a diverse spectrum of extracellular enzymes. In nature, extracellular enzymes primarily serve to procure nutrients for the survival and growth of the fungi. Complex polymers such as lignocellulose and starch as well as proteins and fats are broken down into their basic building blocks by extracellular enzymes such as amylases, proteases, lipases, xylanases, laccases, and many more. Read More

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http://dx.doi.org/10.1007/10_2019_85DOI Listing
February 2019

Isolation and Cultivation of Alkaliphiles.

Authors:
Vadim V Kevbrin

Adv Biochem Eng Biotechnol 2019 Feb 23. Epub 2019 Feb 23.

Winogradsky Institute of Microbiology, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia.

Alkaliphilic microorganisms are ubiquitous and inhabit various econiches on Earth. Alkaline environments suitable for alkaliphilic microbial communities may be created by certain geological processes or human activities. Moreover, a significant contribution to the emergence of alkaline conditions may be due to the activity of neutralophilic microorganisms through certain reactions, which explains the widespread distribution of alkaliphiles. Read More

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http://dx.doi.org/10.1007/10_2018_84DOI Listing
February 2019

Genomics of Alkaliphiles.

Adv Biochem Eng Biotechnol 2019 Feb 23. Epub 2019 Feb 23.

Centre for Microbial Ecology and Genomics, Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.

Alkalinicity presents a challenge for life due to a "reversed" proton gradient that is unfavourable to many bioenergetic processes across the membranes of microorganisms. Despite this, many bacteria, archaea, and eukaryotes, collectively termed alkaliphiles, are adapted to life in alkaline ecosystems and are of great scientific and biotechnological interest due to their niche specialization and ability to produce highly stable enzymes. Advances in next-generation sequencing technologies have propelled not only the genomic characterization of many alkaliphilic microorganisms that have been isolated from nature alkaline sources but also our understanding of the functional relationships between different taxa in microbial communities living in these ecosystems. Read More

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http://dx.doi.org/10.1007/10_2018_83DOI Listing
February 2019
3 Reads

Solid-State Anaerobic Digestion for Waste Management and Biogas Production.

Adv Biochem Eng Biotechnol 2019 Feb 23. Epub 2019 Feb 23.

Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, USA.

Solid-state anaerobic digestion (SS-AD) is commonly used to treat feedstocks with high solid content such as municipal solid waste and lignocellulosic biomass. Compared to liquid state anaerobic digestion (LS-AD), SS-AD has multiple advantages including high organic loading, minimal digestate generated, and low energy requirement for heating. However, the main disadvantages limiting the efficiency of SS-AD are long solid retention time, incomplete mixing, and an accumulation of inhibitors. Read More

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http://dx.doi.org/10.1007/10_2019_86DOI Listing
February 2019
2 Reads

Fermented Solids and Their Application in the Production of Organic Compounds of Biotechnological Interest.

Adv Biochem Eng Biotechnol 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

We review the application of dry fermented solids (DFS) containing naturally immobilized enzymes as catalysts in synthesis and in hydrolysis reactions. The most studied application is the use of DFS containing lipases in the synthesis of biodiesel esters, by transesterification of oils or by esterification of fatty acids with short-chain alcohols in solvent-free reaction media. Other applications of DFS that have been studied include the use of DFS containing pectinases to liberate D-galacturonic acid from pectin and the production of high-value compounds by DFS containing lipases, such as the synthesis of sugar esters and the production of pure enantiomers by resolution of racemic mixtures. Read More

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http://dx.doi.org/10.1007/10_2019_88DOI Listing
February 2019
2 Reads

Application Potentials of Geobiotechnology in Mining, Mineral Processing, and Metal Recycling.

Adv Biochem Eng Biotechnol 2019 Feb 19. Epub 2019 Feb 19.

G.E.O.S. Ingenieurgesellschaft mbH, Halsbrücke, Germany.

This chapter highlights the huge and manifold possibilities of reactions which result from the interactions between microorganisms and the geosphere and which are used for mining, mineral processing, and metal recycling. Besides the introduction (Sect. 1) the contribution is divided into five different sections describing the mobilization (Sect. Read More

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http://dx.doi.org/10.1007/10_2018_82DOI Listing
February 2019
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Environmental Concerns Regarding Ionic Liquids in Biotechnological Applications.

Adv Biochem Eng Biotechnol 2019 Feb 2. Epub 2019 Feb 2.

School of Chemical Engineering, Chonbuk National University, Jeonju, South Korea.

Ionic liquids provide challenges and opportunities for sustainable industrial developments. However, the toxic impacts of ionic liquids reported by many researchers cannot be overlooked. Therefore, in this chapter, we introduce the antimicrobial activities of ionic liquids in bioprocesses and, in greater detail, we discuss their environmental impacts, including the toxicity, biodegradability, bioaccumulation, and mobility of ionic liquids. Read More

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http://dx.doi.org/10.1007/10_2018_79DOI Listing
February 2019
2 Reads

History, Current State, and Emerging Applications of Industrial Biotechnology.

Adv Biochem Eng Biotechnol 2019 Jan 23. Epub 2019 Jan 23.

DECHEMA - Gesellschaft für Chemische Technik und Biotechnologie e.V, Frankfurt am Main, Germany.

The past 150 years have seen remarkable discoveries, rapidly growing biological knowledge, and giant technological leaps providing biotechnological solutions for healthcare, food production, and other societal needs. Genetic engineering, miniaturization, and ever-increasing computing power, in particular, have been key technological drivers for the past few decades. Looking ahead, the eventual transition from fossil resources to biomass and CO demands a shift toward a 'bio-economy' based on novel production processes and engineered organisms. Read More

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http://dx.doi.org/10.1007/10_2018_81DOI Listing
January 2019
1 Read

Whole-Cell Biocatalysis in Ionic Liquids.

Adv Biochem Eng Biotechnol 2018 Nov 29. Epub 2018 Nov 29.

Department of Biological Engineering, Inha University, Incheon, South Korea.

The use of whole-cell biocatalysis in ionic liquid (IL)-containing systems has attracted increasing attention in recent years. Compared to bioreactions catalyzed by isolated enzymes, the major advantage of using whole cells in biocatalytic processes is that the cells provide a natural intracellular environment for the enzymes to function with in situ cofactor regeneration. To date, the applications of whole-cell biocatalysis in IL-containing systems have focused on the production of valuable compounds, mainly through reduction, oxidation, hydrolysis, and transesterification reactions. Read More

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http://dx.doi.org/10.1007/10_2018_77DOI Listing
November 2018
1 Read

Extraction and Isolation of Natural Organic Compounds from Plant Leaves Using Ionic Liquids.

Adv Biochem Eng Biotechnol 2018 Nov 16. Epub 2018 Nov 16.

Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Tokyo, Japan.

Plants contain many kinds of natural organic compounds, and their compounds possess many useful properties. Natural organic compounds are important for the development of medicines, pesticides, fragrances, cosmetics, and synthetic chemicals. In this chapter, we introduce efficient methods for extraction and isolation of valuable natural organic compounds from various plant leaves by using cellulose-dissolving ionic liquids. Read More

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http://dx.doi.org/10.1007/10_2018_80DOI Listing
November 2018
19 Reads

Engineering of Yeast Glycoprotein Expression.

Adv Biochem Eng Biotechnol 2018 Nov 7. Epub 2018 Nov 7.

VIB-UGent Center for Medical Biotechnology, Ghent, Belgium.

Yeasts are valuable hosts for recombinant protein production, as these unicellular eukaryotes are easy to handle, grow rapidly to a high cell density on cost-effective defined media, often offer a high space-time yield, and are able to perform posttranslational modifications. However, a key difference between yeasts and mammalian cells involves the type of glycosylation structures, which hampers the use of yeasts for the production of many biopharmaceuticals. Glycosylation is not only important for the folding process of most recombinant proteins; it has a large impact on pharmacokinetics and pharmacodynamics of the therapeutic proteins as well. Read More

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http://link.springer.com/10.1007/10_2018_69
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http://dx.doi.org/10.1007/10_2018_69DOI Listing
November 2018
12 Reads

Green Chemistry and Its Contribution to Industrial Biotechnology.

Adv Biochem Eng Biotechnol 2018 Oct 1. Epub 2018 Oct 1.

Institute of Sustainable and Environmental Chemistry, Leuphana University of Lüneburg, Lüneburg, Germany.

Sustainable chemistry is a broad framework that starts with the function that a chemical product is offering. Not only chemical but also economic and ethical aspects come into focus throughout the complete lifecycle of chemical products. Green chemistry is an important building block for sustainable chemistry and addresses the issue of greener synthesis and, to a certain degree, the more benign properties of chemicals. Read More

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http://dx.doi.org/10.1007/10_2018_73DOI Listing
October 2018

Electrification of Biotechnology: Quo Vadis?

Adv Biochem Eng Biotechnol 2019;167:395-411

Department of Environmental Microbiology, Helmholtz-Centre for Environmental Research, Leipzig, Germany.

Electrobiotechnology has come a long way and has gained much interest among researchers all over the world. In the previous chapters of this book, an abundance of successful developments of lab-scale electrobiosynthesis and their underlying fundamentals are described. Thereby the individual needs and lines of research are highlighted. Read More

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http://link.springer.com/10.1007/10_2018_75
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http://dx.doi.org/10.1007/10_2018_75DOI Listing
January 2019
8 Reads

Risk Assessment of Processes and Products in Industrial Biotechnology.

Adv Biochem Eng Biotechnol 2018 Sep 23. Epub 2018 Sep 23.

Faculty of Technology, Policy and Management, Safety and Security Science Group (S3G), TU Delft, Delft, The Netherlands.

Risk assessment has been used extensively as the main approach to prevent accidents in the chemical and process industry. Industrial biotechnology has many of the same hazards as chemical technology, but also encounters biological hazards related to biological agents. Employees in the biotechnology industry are susceptible to health risks because of different types of exposure to harmful agents. Read More

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http://link.springer.com/10.1007/10_2018_74
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http://dx.doi.org/10.1007/10_2018_74DOI Listing
September 2018
2 Reads

Biopolymer-Based Composite Materials Prepared Using Ionic Liquids.

Adv Biochem Eng Biotechnol 2018 Sep 22. Epub 2018 Sep 22.

Department of Biological Engineering, Konkuk University, Seoul, South Korea.

Biopolymer-based composite materials have many potential applications in biomedical, pharmaceutical, environmental, biocatalytic, and bioelectronic fields, owing to their inherent biocompatibility and biodegradability. When used as solvents, ionic liquids can be used to fabricate biopolymers such as polysaccharides and proteins into various forms, including molded shapes, films, fibers, and beads. This article summarizes the processes for preparing biopolymer-based composite materials using ionic liquids. Read More

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http://dx.doi.org/10.1007/10_2018_78DOI Listing
September 2018
1 Read

Interplay of Carbohydrate and Carrier in Antibacterial Glycoconjugate Vaccines.

Adv Biochem Eng Biotechnol 2018 Aug 25. Epub 2018 Aug 25.

Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.

Bacterial infections are a serious health concern and are responsible for millions of illnesses and deaths each year in communities around the world. Vaccination is an important public health measure for reducing and eliminating this burden, and regions with comprehensive vaccination programs have achieved significant reductions in infection and mortality. This is often accomplished by immunization with bacteria-derived carbohydrates, typically in conjunction with other biomolecules, which induce immunological memory and durable protection against bacterial human pathogens. Read More

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http://dx.doi.org/10.1007/10_2018_71DOI Listing

Bacterial Glycoengineering as a Biosynthetic Route to Customized Glycomolecules.

Adv Biochem Eng Biotechnol 2018 Aug 12. Epub 2018 Aug 12.

School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.

Bacteria have garnered increased interest in recent years as a platform for the biosynthesis of a variety of glycomolecules such as soluble oligosaccharides, surface-exposed carbohydrates, and glycoproteins. The ability to engineer commonly used laboratory species such as Escherichia coli to efficiently synthesize non-native sugar structures by recombinant expression of enzymes from various carbohydrate biosynthesis pathways has allowed for the facile generation of important products such as conjugate vaccines, glycosylated outer membrane vesicles, and a variety of other research reagents for studying and understanding the role of glycans in living systems. This chapter highlights some of the key discoveries and technologies for equipping bacteria with the requisite biosynthetic machinery to generate such products. Read More

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http://dx.doi.org/10.1007/10_2018_72DOI Listing
August 2018
17 Reads

Synthesis of Ionic Liquids Originated from Natural Products.

Authors:
Hiroyuki Ohno

Adv Biochem Eng Biotechnol 2018 Aug 10. Epub 2018 Aug 10.

Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.

In this chapter, preparation, basic properties, and some applications of ionic liquids composed of naturally-derived ions are summarized. There are many candidate ions in nature suitable for ionic liquid preparation. Physicochemical properties and preparation of some ionic liquids based on carboxylate anions, cholinium cation, and even amino acids are mentioned. Read More

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http://dx.doi.org/10.1007/10_2018_68DOI Listing

Glyco-Engineering of Plant-Based Expression Systems.

Adv Biochem Eng Biotechnol 2018 Aug 2. Epub 2018 Aug 2.

Institute for Molecular Biotechnology, RWTH Aachen University, Aachen, Germany.

Most secreted proteins in eukaryotes are glycosylated, and after a number of common biosynthesis steps the glycan structures mature in a species-dependent manner. Therefore, human therapeutic proteins produced in plants often carry plant-like rather than human-like glycans, which can affect protein stability, biological function, and immunogenicity. The glyco-engineering of plant-based expression systems began as a strategy to eliminate plant-like glycans and produce human proteins with authentic or at least compatible glycan structures. Read More

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http://dx.doi.org/10.1007/10_2018_76DOI Listing
August 2018
9 Reads

Economic Aspects of Industrial Biotechnology.

Authors:
Gunter Festel

Adv Biochem Eng Biotechnol 2018 Jul 26. Epub 2018 Jul 26.

Festel Capital, Fuerigen, Switzerland.

Industrial biotechnology is a key tool in the switch from a petro-based to a bio-based economy. For biotechnological processes to compete competitively in cost with chemical synthesis, the best available state-of-the-art technologies are necessary. In the last few years, industrial biotechnology has undergone fast technological development, resulting in a high number of basic technologies emanating from research efforts at universities and research institutions. Read More

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http://dx.doi.org/10.1007/10_2018_70DOI Listing

Ionic Liquids as Stabilization and Refolding Additives and Solvents for Proteins.

Authors:
Kyoko Fujita

Adv Biochem Eng Biotechnol 2018 Jul 13. Epub 2018 Jul 13.

Department of Pathophysiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.

This chapter focuses on recent advances in the use of ionic liquids as additives and solvents in protein applications. The solvent properties of ionic liquids can be tuned by the appropriate selection of cation and anion. The effects of different kinds of ionic liquids on protein stability and refolding behavior have been investigated and reported. Read More

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http://dx.doi.org/10.1007/10_2018_65DOI Listing
July 2018
6 Reads

Logistics of Lignocellulosic Feedstocks: Preprocessing as a Preferable Option.

Adv Biochem Eng Biotechnol 2019;166:43-68

Bioprocess Engineering, University of Applied Sciences Aachen, Aachen, Germany.

In comparison to crude oil, biorefinery raw materials are challenging in concerns of transport and storage. The plant raw materials are more voluminous, so that shredding and compacting usually are necessary before transport. These mechanical processes can have a negative influence on the subsequent biotechnological processing and shelf life of the raw materials. Read More

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http://dx.doi.org/10.1007/10_2017_58DOI Listing
January 2019

Glycobiotechnology of the Insect Cell-Baculovirus Expression System Technology.

Adv Biochem Eng Biotechnol 2018 Jun 10. Epub 2018 Jun 10.

Protein Sciences Corporation, A Sanofi Company, Meriden, CT, USA.

The insect cell-baculovirus expression system technology (BEST) has a prominent role in producing recombinant proteins to be used as research and diagnostic reagents and vaccines. The glycosylation profile of proteins produced by the BEST is composed predominantly of terminal mannose glycans, and, in Trichoplusia ni cell lines, core α3 fucosylation, a profile different to that in mammals. Insects contain all the enzymatic activities needed for complex N- and O-glycosylation and sialylation, although few reports of complex glycosylation and sialylation by the BEST exist. Read More

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http://link.springer.com/10.1007/10_2018_61
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http://dx.doi.org/10.1007/10_2018_61DOI Listing
June 2018
4 Reads

Erratum to: Engineering of Microbial Electrodes.

Adv Biochem Eng Biotechnol 2019 ;167:413

IMTEK - Department of Microsystems Engineering, University of Freiburg, Freiburg im Breisgau, Germany.

In 30th page, Table 2, in the last row, the references 33 and 134 are inserted. Read More

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http://dx.doi.org/10.1007/10_2017_43DOI Listing
January 2019

Natural Deep Eutectic Solvents and Their Applications in Biotechnology.

Authors:
Zhen Yang

Adv Biochem Eng Biotechnol 2018 May 24. Epub 2018 May 24.

College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, P. R. China.

Following the appearance of ionic liquids (ILs) and deep eutectic solvents (DESs), natural deep eutectic solvents (NADESs) have emerged as a new type of truly green solvents with many excellent advantages such as cheapness, sustainability, biocompatibility, environmental friendliness, and, in particular, remarkable solubilizing power and outstanding designability. Although only at an early stage, research on NADESs has started to blossom with exponential growth, showing attractive and promising potentials for applications in various areas. In this chapter we focus on an introduction to what is currently known about NADESs: their formation, structure and roles in nature, their physical/chemical properties, their toxicity and biodegradability, and, more importantly, their beneficial applications in biotechnology. Read More

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http://dx.doi.org/10.1007/10_2018_67DOI Listing
May 2018
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An Introduction to "Recent Trends in the Biotechnology Industry: Development and Manufacturing of Recombinant Antibodies and Proteins".

Adv Biochem Eng Biotechnol 2018;165:1-8

Biogen International GmbH, International Manufacturing, Zug, Switzerland.

The production of the first therapeutic proteins in the early 1980s heralded the launch of the biopharmaceuticals industry. The number of approved products has grown year on year over the past three decades to now represent a significant share of the entire pharmaceuticals market. More than 200 therapeutic proteins have been approved, approximately a quarter of which are represented by monoclonal antibodies and their derivatives. Read More

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http://dx.doi.org/10.1007/10_2017_39DOI Listing
January 2018
1 Read

Ionic Liquids in Bioseparation Processes.

Adv Biochem Eng Biotechnol 2018 May 10. Epub 2018 May 10.

CICECO-Aveiro Institute of Materials, Chemistry Department, University of Aveiro, Aveiro, Portugal.

Bioseparation processes are a relevant part of modern biotechnology, particularly regarding the development of efficient and biocompatible methods for the separation and purification of added-value biologically active compounds. In this field, ionic liquids (ILs) have been proposed, either in liquid-liquid extractions, in which non-water miscible ILs or aqueous biphasic systems (ABS) formed by ILs can be used, or in solid-liquid extractions, in which they are covalently attached to create supported IL phases (SILPs). Aprotic ILs possess unique properties, such as non-volatility and designability, which are valuable in their use in bioseparation processes. Read More

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http://dx.doi.org/10.1007/10_2018_66DOI Listing
May 2018
2 Reads

Advances in Processing Chitin as a Promising Biomaterial from Ionic Liquids.

Adv Biochem Eng Biotechnol 2018 May 10. Epub 2018 May 10.

525 Solutions, Inc., Tuscaloosa, AL, USA.

Chitin isolated through microwave-assisted dissolution using ionic liquids is a high molecular weight (MW) polymer that can be manufactured into materials of different architectures (e.g., fibers, films, microspheres, nanostructured materials) to be used as wound care dressings, drug delivery devices, scaffolds, etc. Read More

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http://dx.doi.org/10.1007/10_2018_63DOI Listing
May 2018
3 Reads

Ionic Liquid Pretreatment of Lignocellulosic Biomass for Enhanced Enzymatic Delignification.

Adv Biochem Eng Biotechnol 2018 May 10. Epub 2018 May 10.

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Fukuoka, Japan.

Ionic liquids (ILs), a potentially attractive "green," recyclable alternative to environmentally harmful volatile organic compounds, have been increasingly exploited as solvents and/or cosolvents and/or reagents in a wide range of applications, including pretreatment of lignocellulosic biomass for further processing. The enzymatic delignification of biomass to degrade lignin, a complex aromatic polymer, has received much attention as an environmentally friendly process for clean separation of biopolymers including cellulose and lignin. For this purpose, enzymes are generally isolated from naturally occurring fungi or genetically engineered fungi and used in an aqueous medium. Read More

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http://dx.doi.org/10.1007/10_2018_64DOI Listing

Activation of Lipase-Catalyzed Reactions Using Ionic Liquids for Organic Synthesis.

Authors:
Toshiyuki Itoh

Adv Biochem Eng Biotechnol 2018 May 10. Epub 2018 May 10.

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori, Japan.

The use of ionic liquids to replace organic or aqueous solvents in biocatalysis processes has recently received great attention, and much progress has been made in this area; the lipase-catalyzed reactions are the most successful. Recent developments in the application of ionic liquids as solvents in lipase-catalyzed reactions for organic synthesis are reviewed, focusing on the ionic liquid mediated activation method of lipase-catalyzed reactions. Read More

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http://dx.doi.org/10.1007/10_2018_62DOI Listing

A Different Perspective: How Much Innovation Is Really Needed for Monoclonal Antibody Production Using Mammalian Cell Technology?

Adv Biochem Eng Biotechnol 2018;165:443-462

Genentech (A Member of the Roche Group), San Francisco, CA, USA.

As biopharmaceutical companies have optimized cell line and production culture process development, titers of recombinant antibodies have risen steadily to 3-8 g/L for fed-batch mammalian cultures at production scales of 10 kL or larger. Most new antibody products are produced from Chinese Hamster Ovary (CHO) cell lines, and there are relatively few alternative production hosts under active evaluation. Many companies have adopted a strategy of using the same production cell line for early clinical phases as well as commercial production, which reduces the risk of product comparability issues during the development lifecycle. Read More

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http://link.springer.com/10.1007/10_2018_59
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http://dx.doi.org/10.1007/10_2018_59DOI Listing
January 2018
13 Reads

Erratum to: Animal Cell Expression Systems.

Adv Biochem Eng Biotechnol 2018 Apr 29. Epub 2018 Apr 29.

Lehrstuhl für Bioprozesstechnik, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany.

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http://dx.doi.org/10.1007/10_2018_60DOI Listing

Reactors for Microbial Electrobiotechnology.

Adv Biochem Eng Biotechnol 2019;167:231-271

Center for Microbial Ecology and Technology (CMET), Ghent University, Ghent, Belgium.

From the first electromicrobial experiment to a sophisticated microbial electrochemical process - it all takes place in a reactor. Whereas the reactor design and materials used strongly influence the obtained results, there are no common platforms for MES reactors. This is a critical convention gap, as cross-comparison and benchmarking among MES as well as MES vs. Read More

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http://link.springer.com/10.1007/10_2017_40
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http://dx.doi.org/10.1007/10_2017_40DOI Listing
January 2019
2 Reads

Biorefineries: A Short Introduction.

Adv Biochem Eng Biotechnol 2019;166:1-11

DECHEMA, Frankfurt am Main, Germany.

The terms bioeconomy and biorefineries are used for a variety of processes and developments. This short introduction is intended to provide a delimitation and clarification of the terminology as well as a classification of current biorefinery concepts. The basic process diagrams of the most important biorefinery types are shown. Read More

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http://dx.doi.org/10.1007/10_2017_4DOI Listing
January 2019
1 Read

Next Generation Biopharmaceuticals: Product Development.

Adv Biochem Eng Biotechnol 2018;165:253-276

Drug Product Services, Lonza AG, Münchensteiner Strasse 38, 4002, Basel, Switzerland.

Therapeutic proteins show a rapid market growth. The relatively young biotech industry already represents 20 % of the total global pharma market. The biotech industry environment has traditionally been fast-pasted and intellectually stimulated. Read More

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http://dx.doi.org/10.1007/10_2016_57DOI Listing
January 2018
6 Reads

Innovation in Cell Banking, Expansion, and Production Culture.

Adv Biochem Eng Biotechnol 2018;165:51-74

Technical Operations, ImmunoGen, Inc., 830 Winter Street, Waltham, MA, 02451, USA.

Cell culture-based production processes enable the development and commercial supply of recombinant protein products. Such processes consist of the following elements: thaw and initiation of culture, seed expansion, and production culture. A robust cell source storage system in the form of a cell bank is developed and cells are thawed to initiate the cell culture process. Read More

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http://dx.doi.org/10.1007/10_2016_56DOI Listing
January 2018
1 Read

Glycoengineering of Mammalian Expression Systems on a Cellular Level.

Adv Biochem Eng Biotechnol 2018 Mar 13. Epub 2018 Mar 13.

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.

Mammalian expression systems such as Chinese hamster ovary (CHO), mouse myeloma (NS0), and human embryonic kidney (HEK) cells serve a critical role in the biotechnology industry as the production host of choice for recombinant protein therapeutics. Most of the recombinant biologics are glycoproteins that contain complex oligosaccharide or glycan attachments representing a principal component of product quality. Both N-glycans and O-glycans are present in these mammalian cells, but the engineering of N-linked glycosylation is of critical interest in industry and many efforts have been directed to improve this pathway. Read More

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http://dx.doi.org/10.1007/10_2017_57DOI Listing
March 2018
9 Reads

TILLING: The Next Generation.

Adv Biochem Eng Biotechnol 2018;164:139-160

Plant Breeding and Genetics Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, IAEA Laboratories Seibersdorf, International Atomic Energy Agency, Vienna International Centre, Vienna, Austria.

Gene space: the final frontier in plant functional genomics. These are the voyages of TILLING, the reverse-genetics strategy that sought to boldly go where no-one had gone before by combining high-density chemical mutagenesis with high-throughput mutation discovery. Its 18-year mission has been to explore new technologies such as next generation sequencing and to seek out new strategies like in silico databases of catalogued EMS-induced mutations from entire mutant plant populations. Read More

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http://dx.doi.org/10.1007/10_2017_54DOI Listing
April 2019
6 Reads

Advances in Sequencing and Resequencing in Crop Plants.

Adv Biochem Eng Biotechnol 2018;164:11-35

Genus plc, De Forest, WI, USA.

DNA sequencing technologies have changed the face of biological research over the last 20 years. From reference genomes to population level resequencing studies, these technologies have made significant contributions to our understanding of plant biology and evolution. As the technologies have increased in power, the breadth and complexity of the questions that can be asked has increased. Read More

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http://link.springer.com/10.1007/10_2017_46
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http://dx.doi.org/10.1007/10_2017_46DOI Listing
April 2019
6 Reads

Trait Mapping Approaches Through Association Analysis in Plants.

Adv Biochem Eng Biotechnol 2018;164:83-108

National Agri-Food Biotechnology Institute (NABI), Mohali, India.

Previously, association mapping (AM) methodology was used to unravel genetic complications in animal science by measuring the complex traits for candidate and non-candidate genes. Nowadays, this statistical approach is widely used to clarify the complexity in plant breeding program-based genome-wide breeding strategies, marker development, and diversity analysis. This chapter is particularly focused on methodologies with limitations and provides an overview of AM models and software used up to now. Read More

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http://dx.doi.org/10.1007/10_2017_50DOI Listing
April 2019
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Genetic Mapping Populations for Conducting High-Resolution Trait Mapping in Plants.

Adv Biochem Eng Biotechnol 2018;164:109-138

The John Bingham Laboratory, National Institute of Agricultural Botany (NIAB), Cambridge, UK.

Fine mapping of quantitative trait loci (QTL) is the route to more detailed molecular characterization and functional studies of the relationship between polymorphism and trait variation. It is also of direct relevance to breeding since it makes QTL more easily integrated into marker-assisted breeding and into genomic selection. Fine mapping requires that marker-trait associations are tested in populations in which large numbers of recombinations have occurred. Read More

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http://dx.doi.org/10.1007/10_2017_48DOI Listing

Metabolomics in Plant Stress Physiology.

Adv Biochem Eng Biotechnol 2018;164:187-236

Department of Ecogenomics and Systems Biology, Faculty of Sciences, University of Vienna, Vienna, Austria.

Metabolomics is an essential technology for functional genomics and systems biology. It plays a key role in functional annotation of genes and understanding towards cellular and molecular, biotic and abiotic stress responses. Different analytical techniques are used to extend the coverage of a full metabolome. Read More

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http://dx.doi.org/10.1007/10_2017_55DOI Listing
April 2019
1 Read

Nanotechnology in Plants.

Adv Biochem Eng Biotechnol 2018;164:263-275

Department of Chemistry and Shands Cancer Center, University of Florida, Gainesville, FL, USA.

The integration of nanotechnology in medicine has had a tremendous impact in the past few decades. The discovery of synthesis of nanomaterials (NMs) and their functions as versatile tools promoted various applications in nano-biotechnology and nanomedicine. Although the physical and chemical methods are still considered as commonly used methods, they introduce several drawbacks such as the use of toxic chemicals (solvent, reducing, and capping agents) and poor control of size, size distribution, and morphology, respectively. Read More

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http://dx.doi.org/10.1007/10_2017_53DOI Listing
April 2019
4 Reads

Plant Genetics and Molecular Biology: An Introduction.

Adv Biochem Eng Biotechnol 2018;164:1-9

International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Hyderabad, India.

The rapidly evolving technologies can serve as a potential growth engine in agriculture as many of these technologies have revolutionized several industries in the recent past. The tremendous advancements in biotechnology methods, cost-effective sequencing technology, refinement of genomic tools, and standardization of modern genomics-assisted breeding methods hold great promise in taking the global agriculture to the next level through development of improved climate-smart seeds. These technologies can dramatically increase our capacity to understand the molecular basis of traits and utilize the available resources for accelerated development of stable high-yielding, nutritious, input-use efficient, and climate-smart crop varieties. Read More

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http://dx.doi.org/10.1007/10_2017_45DOI Listing