223,512 results match your criteria Advances in Vascular Surgery [Journal]


Advances and opportunities for the design of self-sufficient and spatially organized cell-free biocatalytic systems.

Curr Opin Chem Biol 2018 Dec 11;49:97-104. Epub 2018 Dec 11.

Heterogeneous biocatalysis laboratory, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH-CSIC), University of Zaragoza, C/ Pedro Cerbuna 12, 50009, Zaragoza, Spain; ARAID, Aragon I+D foundation, Zaragoza, Spain. Electronic address:

During the past decades, biocatalysis has made important contributions to chemical manufacturing by using both whole-cell and cell-free biotransformation reactions. More recently, multi-enzyme systems that can run step-wise reactions in one-pot with high selectivity are increasingly being developed. The use of multiple isolated enzymes to perform a series of reactions offers operational and process advantages over the use of living or resting cells, but such cell free processes need to be optimized to meet industrial productivity and titer requirements. Read More

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December 2018
1 Read

Integrating multilocus DNA data and 3D geometric morphometrics to elucidate species boundaries in the case of Pyrenaearia (Pulmonata: Hygromiidae).

Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.

Department of Zoology and Animal Cell Biology, Faculty of Pharmacy, University of the Basque Country, EHU/UPV, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Araba, Spain; Biodiversity Research Group CIEA Lucio Lascaray, Avda. Miguel de Unamuno 3, 01006, Araba, Spain. Electronic address:

To accurately delimit species the use of multiple character types is essential as all speciation processes are not equally reflected in different data (e.g. morphological, molecular or ecological characters). Read More

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December 2018

m6A modification of non-coding RNA and the control of mammalian gene expression.

Biochim Biophys Acta Gene Regul Mech 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

The biology of non-coding RNA (ncRNA) and the regulation of mammalian gene expression is a rapidly expanding field. In this review, we consider how recent advances in technology, enabling the precise mapping of modifications to RNA transcripts, has provided new opportunities to dissect post-transcriptional gene regulation. With this has come the realisation that in the absence of translation, the modification of ncRNAs may play a fundamental role in their regulation, protein interactome and subsequent downstream effector functions. Read More

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December 2018

Cancer Neoantigens.

Annu Rev Immunol 2018 Dec 14. Epub 2018 Dec 14.

Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; email: ,

Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell-based immune system frequently responds to the neoantigens that arise as a consequence of this DNA damage. Furthermore, recognition of neoantigens appears an important driver of the clinical activity of both T cell checkpoint blockade and adoptive T cell therapy as cancer immunotherapies. Read More

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December 2018

Reversing wetland death from 35,000 cuts: Opportunities to restore Louisiana's dredged canals.

PLoS One 2018 14;13(12):e0207717. Epub 2018 Dec 14.

University of Central Florida, Orlando, Florida, United States of America.

We determined the number of permits for oil and gas activities in 14 coastal Louisiana parishes from 1900 to 2017, compared them to land loss on this coast, and estimated their restoration potential. A total of 76,247 oil and gas recovery wells were permitted, of which 35,163 (46%) were on land (as of 2010) and 27,483 of which are officially abandoned. There is a direct spatial and temporal relationship between the number of these permits and land loss, attributable to the above and belowground changes in hydrology resulting from the dredged material levees placed parallel to the canal (spoil banks). Read More

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December 2018
1 Read

Dissecting the regulation and function of ATP at the single-cell level.

PLoS Biol 2018 Dec 14;16(12):e3000095. Epub 2018 Dec 14.

Center for Quantitative Biology and Peking-Tsinghua Joint Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Regulation of cellular ATP level is critical for diverse biological processes and may be defective in diseases such as cancer and mitochondrial disorders. While mitochondria play critical roles in ATP level regulation, we still lack a systematic and quantitative picture of how individual mitochondrial-related genes contribute to cellular ATP level and how dysregulated ATP levels may affect downstream cellular processes. Advances in genetically encoded ATP biosensors have provided new opportunities for addressing these issues. Read More

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December 2018

Current Practices in the Processing, Diagnosis, and Reporting of Endometrial Carcinoma: Results of a Web-based Survey by the International Society of Gynecological Pathologists (ISGyP).

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S3-S8

Department of Pathology and Obstetrics and Gynecology, Yale School of Medicine and the Yale School of Public Health, New Haven, Connecticut (V.P.) Department of Pathology, Hospital University Arnau de Vilanova and University de Bellvitge, Irblleida, Idibell, University of Lleida, Ciberonc, Lleida, Spain (X.M.G.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (E.O.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.).

There have been significant advances in our understanding of the biology and classification of endometrial carcinoma, over the last few years, and the new prediction models proposed for prognostication. To accurately diagnose and stage tumors and apply these prediction models, it is necessary that there be standardized processing of specimens, and a common understanding and usage of the diagnostic terminology of endometrial carcinoma. The International Society of Gynecological Pathologists embarked on an ambitious project to achieve this goal in 2015. Read More

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January 2019

Lipoprotein metabolism in liver diseases.

Curr Opin Lipidol 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: The liver is the central hub of lipoprotein metabolism. A complex relationship exists between dyslipidemia and chronic liver diseases (CLDs). Recent advances in the genetics of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) exemplify the pivotal role of lipoprotein metabolism in the pathogenesis of CLD. Read More

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December 2018

Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.

Syst Biol Reprod Med 2018 Dec 14:1-16. Epub 2018 Dec 14.

b Division of Pharmacology and Toxicology , CSIR- Indian Institute of Chemical Technology , Hyderabad , India.

We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4-8 (encoding ligand binding domain). Read More

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December 2018

[Advances in osteoradionecrosis of nasopharynx after radiotherapy for nasopharyngeal carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1839-1842

Radiation therapy is the first choice for the treatment of nasopharyngeal carcinoma. However, it is inevitable that nasopharyngeal mucosa and tissue will be damaged after radiotherapy of nasopharyngeal carcinoma, which will cause corresponding complications. Nasopharyngeal osteonecrosis is a serious complication. Read More

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December 2018

[Research progress of biologics in the treatment of chronic rhinosinusitis].

Authors:
Y Liu F Yuan

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1515-1518

Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal airways and paranasal sinuses. The condition is defined by more than 12 weeks of nasal obstruction, nasal discharge, facial pain/pressure, and reduced/lost smell. CRS is commonly further classified into 2 subsets based on its clinical phenotype: those with polyps (CRSwNP) and those without (CRSsNP). Read More

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October 2018

[Advances in the treatment of tinnitus].

Authors:
D Wu Y Zheng T Xiang

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1436-1440

Tinnitus is the perception of sound without an external source. Its impact is wide-ranging and heterogeneous across individuals. Since tinnitus is a subjective sensation, the treatment of tinnitus is still in the research and exploration stage at present. Read More

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September 2018

[Advances in prevention of pharyngocutaneous fistula after total laryngectomy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1917-1922

Total laryngectomy is a common method for the treatment of malignant tumors of the pharynx and larynx in China, but pharyngocutaneous fistula often happens after surgery, which burdens patients and affects postoperative recovery. At present, there are many measures to prevent pharyngocutaneous fistula, including strengthening nutrition pre-operative and post-operative, testing related indicators, controlling comorbidities, rational use of drugs, regular oral care, optimal selection of incision closure, and using of flaps and special materials during operation, etc. However, the choice of specific program needs to take care of the patient's condition, surgeon's skills and hospital conditions, and often requires multiple programs to be used together throughout the perioperative period. Read More

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December 2018

Cell Segmentation for Image Cytometry: Advances, Insufficiencies, and Challenges.

Authors:
Zhenzhou Wang

Cytometry A 2018 Dec 14. Epub 2018 Dec 14.

College of electrical and electronic engineering, Shandong University of Technology, 255000, Zibo City, Shandong Province, China.

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December 2018

Single Slide Assessment - A highly effective cytological ROSE technique for EBUS and EUS guided FNA.

Cytopathology 2018 Dec 14. Epub 2018 Dec 14.

Department of Diagnostic and Molecular Pathology, Royal Cornwall Hospital, Truro, Cornwall, UK.

No standardised, comprehensive approach to Rapid On-Site Evaluation (ROSE) of cytology samples currently exists. Recent meta-analysis indicates variation in the effectiveness of ROSE [1], however, reviews commonly omit the details of how ROSE is conducted. This review demonstrates the clinical effectiveness of Single Slide Assessment (SSA) for ROSE of cytology samples, providing a highly effective, standardised methodology, maximising cell yield and the diagnostic potential of samples obtained via Endobronchial or Endoscopic ultrasound (EBUS/EUS). Read More

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December 2018

Getting TANned: How the tumor microenvironment drives neutrophil recruitment.

J Leukoc Biol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.

The directed migration of neutrophils to sites of injury or infection is mediated by complex networks of chemoattractant-receptor signaling cascades. The recent appreciation of neutrophils as active participants in tumor progression and metastasis has drawn attention to a number of chemokine-receptor systems that may drive their recruitment to tumors. However, the dynamic nature of the tumor microenvironment (TME) along with the phenotypic diversity among tumor-associated neutrophils (TANs) call for a more comprehensive approach to understand neutrophil trafficking to tumors. Read More

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December 2018

Fused Aromatic Network Structures as a Platform for Efficient Electrocatalysis.

Adv Mater 2018 Dec 14:e1805062. Epub 2018 Dec 14.

School of Energy and Chemical Engineering, Center for Dimension-Controllable Organic Frameworks, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST, Ulsan, 44919, South Korea.

Fused aromatic network (FAN) structures are a category of ordered porous polymers that permit the specific fusion of building blocks into extended porous network structures with designed skeletons and pores. One significant feature of FANs is that their structures can be tailorable with fused aromatic rings without rotatable single-bond connectivity. As a result, the geometry and space orientation of the building blocks are easily incorporated to guide the topological expansion of the architectural periodicity. Read More

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December 2018

Models and machines: How deep learning will take clinical pharmacology to the next level.

CPT Pharmacometrics Syst Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Roche Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Switzerland.

Recent advances in machine learning (ML) have led to enthusiasm about its use throughout the biopharmaceutical industry. ML methods can be applied to a wide range of problems and have the potential to revolutionize aspects of drug development. The incorporation of ML in modeling and simulation (M+S) has been eagerly anticipated and in this perspective we highlight examples where ML and M+S approaches can be integrated as complementary parts of a clinical pharmacology workflow. Read More

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December 2018

Beyond the Message: Advantages of Snapshot Proteomics with Single-Cell Mass Cytometry in Solid Tumors.

FEBS J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.

Single-cell technologies that can quantify features of individual cells within a tumor are critical for treatment strategies aiming to target cancer cells while sparing or activating beneficial cells. Given that key players in protein networks are often the primary targets of precision oncology strategies, it is imperative to transcend the nucleic acid message and read cellular actions in human solid tumors. Here, we review the advantages of single-cell mass cytometry. Read More

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December 2018

Understanding others: emotion recognition abilities in humans and other animals.

Genes Brain Behav 2018 Dec 13:e12544. Epub 2018 Dec 13.

Genetics of Cognition laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy.

Emotion recognition represents the ability to encode an ensemble of sensory stimuli providing information about the emotional state of another individual. This ability is not unique to humans. An increasing number of studies suggests that many aspects of higher order social functions, including emotion recognition, might be present in species ranging from primates to rodents, indicating a conserved role of these abilities in social animals. Read More

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December 2018

Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes.

Adv Mater 2018 Dec 14:e1804395. Epub 2018 Dec 14.

Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.

Recent advances in cancer immunotherapy have exploited the efficient potential of natural killer (NK) cells to kill tumor cells through antibody-dependent cell-mediated cytotoxicity (ADCC). However, this therapeutic strategy is seriously limited by tumor antigen heterogeneity since antibodies can only recognize specific antigens. In this work, modified antibodies or their Fc fragments that can target solid tumors without the necessity of specific antigen presentation on tumors are developed. Read More

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December 2018

The genomic alterations of lung adenocarcinoma and lung squamous cell carcinoma can explain the differences of their overall survival rates.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Oncology Department, Tianjin Medical University General Hospital, Tianjin, China.

In the US, lung carcinoma accounted for over 150,000 deaths in 2018 and the advances in increasing survival rates are still limited. In this study, we investigated the cohorts with lung adenocarcinoma (LUAD) or lung squamous cell carcinoma (LUSC) from The Cancer Genome Atlas to figure out the risk factors and genomic alterations that affected their prognosis. The histoclinical factors that differed between LUAD and LUSC were identified and the risk factors affecting the overall survival were figured out for both LUAD and LUSC. Read More

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December 2018

Whole Mouse Brain Reconstruction and Registration to a Reference Atlas with Standard Histochemical Processing of Coronal Sections.

J Comp Neurol 2018 Dec 14:e24602. Epub 2018 Dec 14.

Section on Neuroanatomy, NIMH, Bethesda, MD.

Advances in molecular neuroanatomical tools have expanded the ability to map in detail connections of specific neuron subtypes in the context of behaviorally driven patterns of neuronal activity. Analysis of such data across the whole mouse brain, registered to a reference atlas, aids in understanding the functional organization of brain circuits related to behavior. A process is described to image mouse brain sections labeled with standard histochemical techniques, reconstruct those images into a whole brain image volume and register those images to the Allen Mouse Brain Common Coordinate Framework. Read More

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December 2018

Motor Neuroprostheses.

Authors:
Arthur Prochazka

Compr Physiol 2018 Dec 13;9(1):127-148. Epub 2018 Dec 13.

Neuroscience and Mental Health Institute (NMHI), School of Molecular & Systems Medicine, University of Alberta, Edmonton, Alberta, Canada.

Neuroprostheses (NPs) are electrical stimulators that activate nerves, either to provide sensory input to the central nervous system (sensory NPs), or to activate muscles (motor NPs: MNPs). The first MNPs were belts with inbuilt batteries and electrodes developed in the 1850s to exercise the abdominal muscles. They became enormously popular among the general public, but as a result of exaggerated therapeutic claims they were soon discredited by the medical community. Read More

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December 2018

Genome-Wide Maps of Transcription Regulatory Elements and Transcription Enhancers in Development and Disease.

Compr Physiol 2018 Dec 13;9(1):439-455. Epub 2018 Dec 13.

Blood Research Institute, BloodCenter of Wisconsin, a part of Versiti, Milwaukee, Wisconsin, USA.

Gene expression is regulated by numerous elements including enhancers, insulators, transcription factors, and architectural proteins. Regions of DNA distal to the transcriptional start site, called enhancers, play a central role in the temporal and tissue-specific regulation of gene expression through RNA polymerase II. The identification of enhancers and other cis regulatory elements has largely been possible due to advances in next generation sequencing technologies. Read More

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December 2018

Lymphatic Vessel Network Structure and Physiology.

Compr Physiol 2018 Dec 13;9(1):207-299. Epub 2018 Dec 13.

Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA.

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body. The lymphatic system maintains extracellular fluid homeostasis favorable for optimal tissue function, removing substances that arise due to metabolism or cell death, and optimizing immunity against bacteria, viruses, parasites, and other antigens. This article provides a comprehensive review of important findings over the past century along with recent advances in the understanding of the anatomy and physiology of lymphatic vessels, including tissue/organ specificity, development, mechanisms of lymph formation and transport, lymphangiogenesis, and the roles of lymphatics in disease. Read More

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December 2018

Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches.

Compr Physiol 2018 Dec 13;9(1):75-125. Epub 2018 Dec 13.

St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.

Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. Read More

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December 2018
1.685 Impact Factor

Cell wall traits that influence plant development, immunity and bioconversion.

Plant J 2018 Dec 13. Epub 2018 Dec 13.

Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Piazzale A. Moro, 00185, Roma, Italy.

The architecture of the plant cell wall is highly dynamic, being substantially re-modelled during growth and development. Cell walls determine size and shape of cells and contribute to the functional specialization of tissues and organs. Beyond the physiological dynamics, the wall structure undergoes changes upon biotic or abiotic stresses. Read More

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December 2018

Regulatory B cells and advances in transplantation.

J Leukoc Biol 2018 Dec 13. Epub 2018 Dec 13.

Kidney Transplantation Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand-receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL-10. Read More

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December 2018

Research Advances of Amorphous Metal Oxides in Electrochemical Energy Storage and Conversion.

Small 2018 Dec 13:e1804371. Epub 2018 Dec 13.

School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.

Amorphous metal oxides (AMOs) have aroused great enthusiasm across multiple energy areas over recent years due to their unique properties, such as the intrinsic isotropy, versatility in compositions, absence of grain boundaries, defect distribution, flexible nature, etc. Here, the materials engineering of AMOs is systematically reviewed in different electrochemical applications and recent advances in understanding and developing AMO-based high-performance electrodes are highlighted. Attention is focused on the important roles that AMOs play in various energy storage and conversion technologies, such as active materials in metal-ion batteries and supercapacitors as well as active catalysts in water splitting, metal-air batteries, and fuel cells. Read More

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December 2018
1 Read

Strategies of Combination Drug Delivery for Immune Checkpoint Blockades.

Adv Healthc Mater 2018 Dec 13:e1801099. Epub 2018 Dec 13.

Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.

The past few years have witnessed vast clinical accomplishments of immune checkpoint blockades (ICB), which block the regulatory receptor expressed on immune cells or tumor cells to prevent the suppression of antitumor cytotoxic T-cell responses. Despite this, limitations still exist, such as low objective response rate (ORR) and the risk of immune-related side effects. To address these issues, combination treatment strategies are vastly explored and recommended. Read More

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December 2018

Trait-based ecology of terrestrial arthropods.

Biol Rev Camb Philos Soc 2018 Dec 13. Epub 2018 Dec 13.

Department of Zoology, University of Oxford, Oxford, OX1 3PS, U.K.

In focusing on how organisms' generalizable functional properties (traits) interact mechanistically with environments across spatial scales and levels of biological organization, trait-based approaches provide a powerful framework for attaining synthesis, generality and prediction. Trait-based research has considerably improved understanding of the assembly, structure and functioning of plant communities. Further advances in ecology may be achieved by exploring the trait-environment relationships of non-sessile, heterotrophic organisms such as terrestrial arthropods, which are geographically ubiquitous, ecologically diverse, and often important functional components of ecosystems. Read More

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December 2018

CropSNPdb: a database of SNP array data for Brassica crops and hexaploid bread wheat.

Plant J 2018 Dec 13. Epub 2018 Dec 13.

School of Biological Sciences and Institute of Agriculture, The University of Western Australia, Perth, 6009, WA, Australia.

Advances in sequencing technology have led to a rapid rise in the genomic data available for plants, driving new insights into the evolution, domestication and improvement of crops. Single nucleotide polymorphisms (SNPs) are a major component of crop genomic diversity and are invaluable as genetic markers in research and breeding programs. High-throughput SNP arrays, or 'SNP chips', can generate reproducible sets of informative SNP markers and have been broadly adopted. Read More

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December 2018

Salt stress under the scalpel - Dissecting the genetics of salt tolerance.

Plant J 2018 Dec 12. Epub 2018 Dec 12.

King Abdullah University of Science and Technology (KAUST), Division of Biological and Environmental Sciences and Engineering, Thuwal, 23955-6900, Kingdom of Saudi Arabia.

Salt stress limits the productivity of crops grown under saline conditions, leading to substantial yield losses in saline soils and under brackish and saline irrigation. Salt tolerant crops could alleviate these losses while both increasing irrigation opportunities and reducing agricultural demands on dwindling freshwater resources. However, despite significant efforts, progress towards this goal has been limited, largely because of genetic complexity of salt tolerance for agronomically important yield-related traits. Read More

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December 2018

Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.

Aging Cell 2018 Dec 12:e12844. Epub 2018 Dec 12.

Bristol Medical School, University of Bristol, Bristol Royal Infirmary, Bristol, UK.

We previously reported pro-survival effects of Wnt3a and Wnt5a proteins in vascular smooth muscle cells (VSMCs). Wnt5a achieved this through induction of Wnt1-inducible signalling pathway protein-1 (WISP-1) consequent to β-catenin/CREB-dependent, TCF-independent, signalling. However, we found that as atherosclerosis advances, although Wnt5a protein was increased, WISP-1 was reduced. Read More

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December 2018

Genetics of barley tiller and leaf development.

J Integr Plant Biol 2018 Dec 11. Epub 2018 Dec 11.

University of Milan, DiSAA, Via Celoria 2, 20133 Milan, Italy.

In cereals, tillering and leaf development are key factors in the concept of crop ideotype, introduced in the 1960 s to enhance crop yield, via manipulation of plant architecture. In the present review, we discuss advances in genetic analysis of barley shoot architecture, focusing on tillering, leaf size and angle. We also discuss novel phenotyping techniques, such as 2D and 3D imaging, that have been introduced in the era of phenomics, facilitating reliable trait measurement. Read More

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December 2018

Recent Advances in 3D Graphene Architectures and Their Composites for Energy Storage Applications.

Small 2018 Dec 12:e1803858. Epub 2018 Dec 12.

Institute for Superconducting and Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, Wollongong, NSW, 2522, Australia.

Graphene is widely applied as an electrode material in energy storage fields. However, the strong π-π interaction between graphene layers and the stacking issues lead to a great loss of electrochemically active surface area, damaging the performance of graphene electrodes. Developing 3D graphene architectures that are constructed of graphene sheet subunits is an effective strategy to solve this problem. Read More

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December 2018

Bedaquiline and delamanid in the treatment of multidrug-resistant tuberculosis: Promising but challenging.

Drug Dev Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.

Hit, Lead & Candidate Discovery Improving treatment outcomes in multidrug-resistant tuberculosis (MDR-TB) is partly hampered by inadequate effective antitubercular agents. Development of bedaquiline and delamanid has potentially changed the treatment landscape for MDR-TB. This review provides an update on the progress of these novel antitubercular agents. Read More

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December 2018

State-of-the-Art Advances and Challenges of Iron-Based Metal Organic Frameworks from Attractive Features, Synthesis to Multifunctional Applications.

Small 2018 Dec 7:e1803088. Epub 2018 Dec 7.

College of Environmental Science and Engineering, Hunan University, Changsha, 410082, P. R. China.

Metal organic frameworks (MOFs), as an original kind of organic-inorganic porous material, are constructed with metal centers and organic linkers via a coordination complexation reaction. Among uncountable MOF materials, iron-containing metal organic frameworks (Fe-MOFs) have excellent potential in practical applications owing to their many fascinating properties, such as diverse structure types, low toxicity, preferable stability, and tailored functionality. Here, recent research progresses of Fe-MOFs in attractive features, synthesis, and multifunctional applications are described. Read More

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December 2018

Iron Catalysis in Reduction and Hydrometalation Reactions.

Chem Rev 2018 Dec 14. Epub 2018 Dec 14.

Univ Rennes, CNRS, ISCR-UMR 6226 , F-35000 Rennes , France.

The last two decades have seen an impressive improvement of the use of iron as a fascinating and valuable alternative transition metal in homogeneous catalysis in terms of sustainability and economy. It was efficiently used in catalytic organic synthetic transformations, which in particular include the reduction of unsaturated bonds. This review summarizes the fast development and the recent advances in selective reductions of olefins, alkynes, carbonyl and carboxylic derivatives, imines, and nitro compounds promoted by iron catalysts. Read More

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December 2018

New Dual Combination of Dolutegravir-Rilpivirine for Switching to Maintenance Antiretroviral Therapy.

Authors:
Esteban Ribera

AIDS Rev 2018 ;20(4):179-186

Department of Infectious Diseases, Hospital Universitari Vall d'Hebron and Universitat Autònoma de Barcelona, Barcelona, Spain.

Advances in antiretroviral therapy have led to dramatic improvements in survival of HIV-infected persons. However, HIV cure remains elusive and lifelong treatment is needed. Attempts for reducing long-term drug exposure, toxicities, and cost, while maintaining viral suppression, have led to explore whether maintenance strategies with less than triple therapy could be feasible using the newest more potent antiretrovirals. Read More

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January 2018

Advances in the understanding of headache in idiopathic intracranial hypertension.

Curr Opin Neurol 2018 Dec 12. Epub 2018 Dec 12.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston.

Purpose Of Review: To review the most relevant developments in the understanding of headache in idiopathic intracranial hypertension (IIH).

Recent Findings: The phenotype of the typical IIH headache is diverging from the historical thinking of a raised intracranial pressure headache, with the majority being classified as having migraine. A larger proportion of those with IIH have a past medical history of migraine, compared with the general population, highlighting the importance of re-examining those who have a change or escalation in their headache. Read More

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December 2018

Update on the diagnosis and management of acute heart failure.

Curr Opin Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Division of Cardiology, Canadian VIGOUR Centre, University of Alberta, Edmonton.

Purpose Of Review: To highlight the advances in the diagnosis and management of acute heart failure (AHF) from recent clinical trials and observational studies.

Recent Findings: We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF. In addition, we summarize the evidence for novel pharmacological therapies including: serelaxin, ularitide, clevidipine, urocortins, BMS-986231, TRB027, vericiguat, omecamtiv, and torsemide. Read More

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December 2018

Advances in the study of egg activation of higher plants.

Zygote 2018 Dec 14:1-8. Epub 2018 Dec 14.

3School of Life Sciences,Xiamen University,Xiamen 361005,China.

SummaryFertilization in higher plants induces many structural and physiological changes in the fertilized egg, and represents the transition from the haploid female gamete to the diploid zygote, the first cell of a sporophyte. Some changes are induced extremely rapidly following fusion with sperm cells and are the preclusions of egg activation. This review focuses on the early changes that occur in the egg after fusion with sperm cells, but before nuclear fusion. Read More

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December 2018

The use of open source GIS algorithms, big geographic data, and cluster computing techniques to compile a geospatial database that can be used to evaluate upstream bathing and sanitation behaviours on downstream health outcomes in Indonesia, 2000-2008.

Int J Health Geogr 2018 Dec 14;17(1):44. Epub 2018 Dec 14.

Department of Geography and Geosciences, Salisbury University, Salisbury, MD, 21801, USA.

Background: Waterborne diseases are one of the leading causes of mortality in developing countries, and diarrhea alone is responsible for over 1.5 million deaths annually. Such waterborne illnesses most often affect those in impoverished rural communities who rely on rivers for their supply of drinking water. Read More

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December 2018

Conference proceedings of the 4th Masterclass Psychiatry: Transcultural Psychiatry - Diagnostics and Treatment, Luleå, Sweden, 22-23 February 2018 (Region Norrbotten in collaboration with the Maudsley Hospital and Tavistock Clinic London).

Authors:
Ursula Werneke

Nord J Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

a Department of Clinical Sciences, Division of Psychiatry, Sunderby Research Unit , Umeå University , Umeå , Sweden.

Background: According to estimates from the European Commission, Europe has experienced the greatest mass movement of people since the Second World War. More than one million refugees and migrants have arrived in the European Union in the past few years. Mental health and primary care professionals are more likely than ever to meet patients from different cultures and backgrounds. Read More

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December 2018

Piezoelectric Effects in Surface-Engineered Two-Dimensional Group III Nitrides.

ACS Appl Mater Interfaces 2018 Dec 14. Epub 2018 Dec 14.

Piezoelectric effects of two-dimensional (2D) group III-V compounds have received considered attention in recent years because of their wide applications in semiconductor devices. However, it faces a problem that only metastable or unstable structures are non-centrosymmetric with piezoelectricity, thus leading to the difficulty in experimental observation. Motivated by the recent advances in the synthesis of 2D group III nitrides, in this paper, for the first time, we study the piezoelectric properties of the 2D group III nitrides (XN, X = Al, Ga, and In) with buckled hexagonal configurations by surface passivation, which are thermodynamically stable. Read More

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December 2018
6.723 Impact Factor

Pursuing Social Justice through Public Health: Gender and Sexual Diversity Activism in Malawi.

Crit Afr Stud 2017 15;9(1):71-90. Epub 2017 Feb 15.

The Center for Medicine, Health, and Society, Vanderbilt University, PMB #351665, 2301 Vanderbilt Pl., Nashville, TN 37235-1665 USA, Telephone: +1-615-322-0718.

African lesbian, gay, bisexual, transgender, intersex, and queer (LGBTIQ) organizations face various strategic dilemmas in contexts characterized by political hostility to gender and sexual dissidents. In Malawi, one such context, we examine how an LGBTIQ social movement organization (SMO) in Malawi, the Centre for the Development of People (CEDEP), navigated one particular strategic dilemma-the dilemma of whether to adopt a less politicized public-health approach or a more nimble, grassroots-oriented, and social-justice approach to their advocacy work-and the consequences of the organization's strategic decisions. Scholars interpret these approaches as signifying differential political engagement among organizations, with the social-justice approach indicating political engagement and the public-health approach signaling political disengagement. Read More

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February 2017

Quadricuspid aortic valve illustrated by 64-slice multidetector computed tomography: Surgical treatment of a rare cause of severe aortic regurgitation.

J Cardiol Cases 2010 Aug 27;2(1):e8-e11. Epub 2010 Jan 27.

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.

The quadricuspid aortic valve (QAV) is a rare congenital malformation that usually presents with aortic regurgitation (AR). The first case was reported in 1862. Most cases were diagnosed at the time of surgery or postmortem examination. Read More

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