5,908 results match your criteria Advances in Skin & Wound Care[Journal]


Crowdsourcing to delineate skin affected by chronic graft-vs-host disease.

Skin Res Technol 2019 Feb 20. Epub 2019 Feb 20.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Estimating the extent of affected skin is an important unmet clinical need both for research and practical management in many diseases. In particular, cutaneous burden of chronic graft-vs-host disease (cGVHD) is a primary outcome in many trials. Despite advances in artificial intelligence and 3D photography, progress toward reliable automated techniques is hindered by limited expert time to delineate cGVHD patient images. Read More

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http://dx.doi.org/10.1111/srt.12688DOI Listing
February 2019

Defining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors.

Eur J Cancer 2019 Feb 19;110:120-126. Epub 2019 Feb 19.

Department of Epidemiological Research and Molecular Medicine, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy. Electronic address:

Although all tumours are rare in childhood, there are some particularly rare paediatric cancers which have not benefited from advances made by the international paediatric oncology network. To establish a shared definition and produce a list of these entities, the European Union Joint Action on Rare Cancers (JARC) promoted a consensus effort. The definition was based on the incidence rates estimated using the information network on rare cancers (RARECAREnet) database, pooling data from 94 population-based cancer registries and 27 countries. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.031DOI Listing
February 2019

Nicotinamide Metabolism Modulates the Proliferation / Differentiation Balance and Senescence of Human Primary Keratinocytes.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Cell Cycle Control in Skin Epidermis, Skin Research Institute of Singapore, A*STAR, 8A Biomedical Grove, Singapore 138648; School of Biological Sciences & Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 637551. Electronic address:

Nicotinamide (NAM) is the main precursor of NAD, a co-enzyme essential for DNA repair, glycolysis and oxidative phosphorylation (OXPHOS). NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3D organotypic skin models, we show that NAM inhibits differentiation of the upper epidermal layers and maintains proliferation in the basal layer. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.005DOI Listing
February 2019

A promising approach to targeting type 1 IFN in systemic lupus erythematosus.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Division of Rheumatology, Cedars-Sinai Medical Center, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

Despite advances in understanding systemic lupus erythematosus (SLE) pathogenesis, most clinical trials of new targeted therapies have been met with disappointment. The type I IFN pathway is believed to play an important role in SLE, and the proposed involvement of this pathway helps explain the frustration behind the failure at targeting either IFN-α or the type 1 IFN receptor itself. In this issue of the JCI, Furie et al. Read More

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http://dx.doi.org/10.1172/JCI127101DOI Listing
February 2019

Bioinspired Adhesive Architectures: From Skin Patch to Integrated Bioelectronics.

Adv Mater 2019 Feb 18:e1803309. Epub 2019 Feb 18.

School of Chemical Engineering, Sungkyunkwan University (SKKU), Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.

The attachment phenomena of various hierarchical architectures found in nature have extensively drawn attention for developing highly biocompatible adhesive on skin or wet inner organs without any chemical glue. Structural adhesive systems have become important to address the issues of human-machine interactions by smart outer/inner organ-attachable devices for diagnosis and therapy. Here, advances in designs of biologically inspired adhesive architectures are reviewed in terms of distinct structural properties, attachment mechanisms to biosurfaces by physical interactions, and noteworthy fabrication methods. Read More

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http://dx.doi.org/10.1002/adma.201803309DOI Listing
February 2019

All MoS-Based Large Area, Skin-Attachable Active-Matrix Tactile Sensor.

ACS Nano 2019 Feb 21. Epub 2019 Feb 21.

School of Electrical and Electronic Engineering , Yonsei University , 50 Yonsei-ro , Seodaemun-gu, Seoul 03722 , Republic of Korea.

Large-area, ultrathin flexible tactile sensors with conformal adherence are becoming crucial for advances in wearable electronics, electronic skins and biorobotics. However, normal passive tactile sensors suffer from high crosstalk, resulting in inaccurate sensing, which consequently limits their use in such advanced applications. Active-matrix-driven tactile sensors could potentially overcome such hurdles, but it demands the high performance and reliable operations of the thin-film-transistor array that could efficiently control integrated pressure gauges. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b07995
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http://dx.doi.org/10.1021/acsnano.8b07995DOI Listing
February 2019
2 Reads
12.881 Impact Factor

Ear Reconstruction Simulation: From Handcrafting to 3D Printing.

Bioengineering (Basel) 2019 Feb 5;6(1). Epub 2019 Feb 5.

Department of Industrial Engineering, University of Florence, via di Santa Marta, 3, 50139 Firenze, Italy.

Microtia is a congenital malformation affecting one in 5000 individuals and is characterized by physical deformity or absence of the outer ear. Nowadays, surgical reconstruction with autologous tissue is the most common clinical practice. The procedure requires a high level of manual and artistic techniques of a surgeon in carving and sculpting of harvested costal cartilage of the patient to recreate an auricular framework to insert within a skin pocket obtained at the malformed ear region. Read More

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http://dx.doi.org/10.3390/bioengineering6010014DOI Listing
February 2019

Heterologous Wharton's Jelly Derived Mesenchymal Stem Cells Application on a Large Chronic Skin Wound in a 6-Month-Old Filly.

Front Vet Sci 2019 30;6. Epub 2019 Jan 30.

Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.

A complex feedback of growth factors, secreted by a variety of cell types, is responsible for the mediation of skin healing. Despite the recent advances in wound healing management, this fails up to 50% and skin wounds can still be considered one of the main causes of morbidity, both in human and veterinary medicine. Regenerative medicine, involving mesenchymal stromal cells (MSCs), is nowadays a promising solution for skin wound healing. Read More

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http://dx.doi.org/10.3389/fvets.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363668PMC
January 2019

Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice.

BMC Cancer 2019 Feb 13;19(1):149. Epub 2019 Feb 13.

Division of RI application, Korea Institute of Radiological and Medical Sciences, 75 Nowon-Gil, Gongneung-Dong, Nowon-Gu, Seoul, 01812, Korea.

Background: Chemotherapy-induced alopecia has been well documented as a cause of distress to patients undergoing cancer treatment. Almost all traditional chemotherapeutic agents cause severe alopecia. Despite advances in the treatment of chemotherapy-induced alopecia, there is no effective treatment for preventing chemotherapy-induced alopecia. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5323-zDOI Listing
February 2019
2 Reads

A Case of Primary Gastric Melanoma Exhibiting a Rare V600R Mutation.

Eur J Case Rep Intern Med 2018 21;5(3):000749. Epub 2018 Mar 21.

Department of Gastroenterology, Tallaght Hospital, Dublin, Ireland.

Introduction: Malignant melanoma of the gastrointestinal tract is usually a metastasis from a cutaneous source. Primary gastric melanoma is an extremely rare clinical entity, with few reported cases worldwide. It is often advanced at time of diagnosis and is associated with a dismal outcome. Read More

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http://dx.doi.org/10.12890/2018_000749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346958PMC

Advances in Ultrasound Mediated Transdermal Drug Delivery.

Curr Pharm Des 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614. United States.

Low frequency ultrasound-assisted drug delivery has been widely investigated as a non-invasive method to enhance the transdermal penetration of drugs. Using this technique, a brief application of ultrasound is used to permeabilize skin for a prolonged time. In this review, an overview on ultrasound is detailed to help explain the parameters that could be modulated to obtain the desired ultrasound parameters for enhanced transdermal drug delivery. Read More

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http://dx.doi.org/10.2174/1381612825666190211163948DOI Listing
February 2019
1 Read

Waterproof, electronics-enabled, epidermal microfluidic devices for sweat collection, biomarker analysis, and thermography in aquatic settings.

Sci Adv 2019 Jan 25;5(1):eaau6356. Epub 2019 Jan 25.

Department of Materials Science and Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL 60208, USA.

Noninvasive, in situ biochemical monitoring of physiological status, via the use of sweat, could enable new forms of health care diagnostics and personalized hydration strategies. Recent advances in sweat collection and sensing technologies offer powerful capabilities, but they are not effective for use in extreme situations such as aquatic or arid environments, because of unique challenges in eliminating interference/contamination from surrounding water, maintaining robust adhesion in the presence of viscous drag forces and/or vigorous motion, and preventing evaporation of collected sweat. This paper introduces materials and designs for waterproof, epidermal, microfluidic and electronic systems that adhere to the skin to enable capture, storage, and analysis of sweat, even while fully underwater. Read More

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http://dx.doi.org/10.1126/sciadv.aau6356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357724PMC
January 2019

Zika virus infection in causes dermatological manifestations and confers protection against secondary infection.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.

Animal models of Zika virus (ZIKV) infection have recently been established in mice, guinea pigs, and nonhuman primates. Tree shrews () are an emerging experimental animal in biomedical applications, but their susceptibility to ZIKV infection has not been explored. In the present study, we showed that subcutaneous inoculation of ZIKV led to rapid viremia and viral secretion in saliva, as well as to typical dermatological manifestations characterized by massive diffuse skin rash on the trunk. Read More

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http://dx.doi.org/10.1128/JVI.01982-18DOI Listing
February 2019
1 Read

Current and Future Perspectives on Skin Tissue Engineering: Key Features of Biomedical Research, Translational Assessment, and Clinical Application.

Adv Healthc Mater 2019 Feb 1:e1801471. Epub 2019 Feb 1.

Fischell Department of Bioengineering, University of Maryland, College Park, College Park, MD, 20742, USA.

The skin is responsible for several important physiological functions and has enormous clinical significance in wound healing. Tissue engineered substitutes may be used in patients suffering from skin injuries to support regeneration of the epidermis, dermis, or both. Skin substitutes are also gaining traction in the cosmetics and pharmaceutical industries as alternatives to animal models for product testing. Read More

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http://dx.doi.org/10.1002/adhm.201801471DOI Listing
February 2019

Noninvasive Featherlight Wearable Compliant "Marine Skin": Standalone Multisensory System for Deep-Sea Environmental Monitoring.

Small 2019 Feb 1:e1804385. Epub 2019 Feb 1.

mmh Labs, Electrical Engineering, Computer Electrical Mathematical Science and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.

Advances in marine research to understand environmental change and its effect on marine ecosystems rely on gathering data on species physiology, their habitat, and their mobility patterns using heavy and invasive biologgers and sensory telemetric networks. In the past, a lightweight (6 g) compliant environmental monitoring system: Marine Skin was demonstrated. In this paper, an enhanced version of that skin with improved functionalities (500-1500% enhanced sensitivity), packaging, and most importantly its endurance at a depth of 2 km in the highly saline Red Sea water for four consecutive weeks is reported. Read More

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http://doi.wiley.com/10.1002/smll.201804385
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http://dx.doi.org/10.1002/smll.201804385DOI Listing
February 2019
10 Reads

A Surgeon's Guide to the Various Antibiotic Dips Available During Penile Prosthesis Implantation.

Curr Urol Rep 2019 Jan 30;20(2):11. Epub 2019 Jan 30.

Department of Urology, University of Miami Miller School of Medicine, 1120 NW 14th Street, 15th Floor, Miami, FL, 33136, USA.

Purpose Of Review: Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to advances in antibiotic dips targeting the skin flora. Read More

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http://dx.doi.org/10.1007/s11934-019-0874-8DOI Listing
January 2019

Development and use of biomaterials as wound healing therapies.

Burns Trauma 2019 25;7. Epub 2019 Jan 25.

3Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052 Australia.

There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction. Read More

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http://dx.doi.org/10.1186/s41038-018-0139-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346526PMC
January 2019

New perspectives in Merkel cell carcinoma.

Curr Opin Oncol 2019 Mar;31(2):72-83

APHP, Department of Dermatology, Saint-Louis Hospital, Sorbonne Paris Cité Université, Paris Diderot, INSERM U976, Paris, France.

Purpose Of Review: Merkel cell carcinoma (MCC), a rapidly progressing skin cancer, has poor prognosis. We reviewed the epidemiology, pathogenesis, diagnosis and treatment of MCC, with a focus on recent therapeutic advancements.

Recent Findings: Risk factors for MCC, such as old age, immunosuppression, polyomavirus infection and exposure to UV radiation have already been identified, but the underlying mechanisms leading to carcinogenesis still need clarification. Read More

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http://Insights.ovid.com/crossref?an=00001622-900000000-9921
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http://dx.doi.org/10.1097/CCO.0000000000000508DOI Listing
March 2019
5 Reads

Black and Brown Oro-facial Mucocutaneous Neoplasms.

Authors:
Easwar Natarajan

Head Neck Pathol 2019 Jan 29. Epub 2019 Jan 29.

Section of Oral and Maxillofacial Pathology, University of Connecticut Health Center, 263 Farmington Ave, MC-0925, Farmington, CT, 06030, USA.

Black and brown-colored mucocutaneous lesions present a differential diagnostic challenge, with malignant melanoma being the primary clinical concern. The vast majority of pigmented lesions in the head and neck region are the result of benign, reactive factors such as post-inflammatory melanosis. However, it is not uncommon to discover a range of muco-cutaneous black and brown neoplasms in the oro-facial area. Read More

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http://dx.doi.org/10.1007/s12105-019-01008-2DOI Listing
January 2019
2 Reads

Immune evasion and current immunotherapy strategies in mycosis fungoides (MF) and Sézary syndrome (SS).

Chin Clin Oncol 2019 Jan 9. Epub 2019 Jan 9.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA; Sidney Kimmel Cancer Center at Jefferson Health, Philadelphia, PA, USA.

Mycosis fungoides (MF) and Sézary syndrome (SS) are two well-characterized skin limited and leukemic subtypes of cutaneous T-cell lymphoma (CTCL), respectively. Progressive global immune dysfunction and a multitude of specific immunological abnormalities have long been recognized as features of MF and SS. Therefore, a variety of immune-based therapies have been explored and used in the clinic for decades in the attempt to restore the immune imbalance in these malignancies. Read More

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http://cco.amegroups.com/article/view/23332
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http://dx.doi.org/10.21037/cco.2019.01.01DOI Listing
January 2019
15 Reads

Recent Advances in Flexible and Wearable Pressure Sensors Based on Piezoresistive 3D Monolithic Conductive Sponges.

ACS Appl Mater Interfaces 2019 Feb 8;11(7):6685-6704. Epub 2019 Feb 8.

High-performance flexible strain and pressure sensors are important components of the systems for human motion detection, human-machine interaction, soft robotics, electronic skin, etc., which are envisioned as the key technologies for applications in future human healthcare monitoring and artificial intelligence. In recent years, highly flexible and wearable strain/pressure sensors have been developed based on various materials/structures and transduction mechanisms. Read More

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http://dx.doi.org/10.1021/acsami.8b20929DOI Listing
February 2019
1 Read

MicroRNAs in Cutaneous T-Cell Lymphoma: The Future of Therapy.

J Invest Dermatol 2019 Jan 24. Epub 2019 Jan 24.

Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA; Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio USA; Department of Medical Oncology, Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

MicroRNAs (miRs) are small, noncoding RNAs with numerous cellular functions. With advancing knowledge of the many functions of miRs in cancer pathogenesis, there is emerging interest in miRs as therapeutic targets in cancers. One disease that poses an intriguing model for miR therapy is cutaneous T-cell lymphoma, a rare disease featuring malignant CD4 T cells that proliferate in the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183281
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http://dx.doi.org/10.1016/j.jid.2018.10.035DOI Listing
January 2019
3 Reads

Type I interferon dysregulation in Systemic Sclerosis.

Cytokine 2019 Jan 23. Epub 2019 Jan 23.

The University of Texas Health Science Center in Houston, Division of Rheumatology, 6431 Fannin, MSB 5.262, Houston, TX 77030, United States. Electronic address:

Systemic Sclerosis (Scleroderma, SSc) is a multifaceted disease characterized by autoimmunity, vasculopathy, and fibrosis affecting the skin and internal organs. Despite advances in the understanding and treatment of SSc in recent years, SSc continues to cause reduced quality of life and premature mortality. Type I interferons (IFNs), a family of cytokines with essential roles in the immune response to microbial infection, play a pathogenic role in certain autoimmune diseases (reviewed elsewhere in this edition). Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.018DOI Listing
January 2019
2 Reads

Recent advances in topical delivery of flavonoids: A review.

J Control Release 2019 Feb 22;296:190-201. Epub 2019 Jan 22.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India. Electronic address:

Flavonoids are one of the vital classes of bioactive chemicals, abundantly found in plants. These are natural polyphenolic compounds derived from plant metabolites. Their lipophilic nature and poor solubility lead to variable and limited oral bioavailability. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.01.029DOI Listing
February 2019

Recent Advances in Mild and Moisturizing Cleansers

J Drugs Dermatol 2019 Jan;18(1s):s80-88

Mild and moisturizing cleanser technologies, and the science underpinning them, have progressed significantly over the past decade. This includes introduction of amino-acid based milder surfactants into the cleansing arena, a deeper understanding of the roles of stratum corneum lipids and proteins in their interaction with cleanser surfactants, the role of pH in skin cleansing, and the development of improved methodologies for predicting skin irritation and drying potential of cleansers. In this paper, the recent advances in these areas as well as newer technologies are reviewed, and the future directions are outlined. Read More

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January 2019

Skin Barrier Insights: From Bricks and Mortar to Molecules and Microbes

Authors:
Carol A. Bosko

J Drugs Dermatol 2019 Jan;18(1s):s63-67

Recent advances in genomics, spectroscopy, and immunology have increased our understanding of the skin barrier. A new model of barrier lipid organization has emerged owing to the application of advanced modeling and microscopy techniques. The contribution of filaggrin gene mutations to atopic dermatitis has increased our appreciation of the role barrier perturbations play in inflammatory dermatoses. Read More

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January 2019
5 Reads

Nursing2019 Skin and wound care survey.

Nursing 2019 Feb;49(2):8-10

Elizabeth A. Ayello is a faculty member at Excelsior College School of Nursing in Albany, N.Y., co-editor-in-chief of Advances in Skin and Wound Care, president of Ayello Harris and Associates in Copake, N.Y., and a Nursing2019 Editorial Board member. Sharon Baranoski is a nurse consultant in Shorewood, Ill.

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http://dx.doi.org/10.1097/01.NURSE.0000552710.96243.38DOI Listing
February 2019

Advances in the pathogenesis representing definite outcomes in chronic urticaria.

Curr Opin Allergy Clin Immunol 2019 Jan 22. Epub 2019 Jan 22.

Universidad de Antioquia, Colombia.

Purpose Of Review: We reviewed in this article, the recent advances in CSU physiopathology and potential clinical and laboratory biomarkers in CSU.

Recent Findings: In addition to the central role of mast cells in urticaria physiopathology, increased interest in basophils has arisen. Recent data corroborate the autoimmunity pathway as one of the main pathways in mast cell activation. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000519DOI Listing
January 2019
3 Reads

Stimulus sensitive smart nano platforms: an emerging paradigm for the treatment of skin diseases.

Curr Drug Deliv 2019 Jan 23. Epub 2019 Jan 23.

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab. India.

Background: Over the past century, prevalence of skin diseases has substantially increased. These diseases present a significant physical, emotional and socio-economic burden to the society. Such conditions are also associated with multitude of psychological traumas to the suffering patients. Read More

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http://dx.doi.org/10.2174/1567201816666190123125813DOI Listing
January 2019
5 Reads
2.248 Impact Factor

Montagna Symposium 2017-Profiling Immune Expression to Consider Repurposing Therapeutics for the Ichthyoses.

Authors:
Amy S Paller

J Invest Dermatol 2019 Jan 19. Epub 2019 Jan 19.

Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:

Despite extensive discovery about the mutations underlying genetic skin disorders, there have been few therapeutic advances. Better understanding of the molecular changes that may lead to the phenotypic manifestations of genetic disorders may lead to the discovery of new pharmacologic interventions. The ichthyoses are characterized by scaling, inflammation, and an impaired epidermal barrier. Read More

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http://dx.doi.org/10.1016/j.jid.2018.08.027DOI Listing
January 2019
1 Read

[Advances on anatomic study and clinical application of submental artery island flap].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;33(1):85-89

After more than 20 years of development, submental artery island flap (SMAIF) has become a versatile flap for head and neck reconstruction of the defects after tumor resection,trauma or facial deformity.The design of SMAIF is flexible and diverse. According to repair requirements,various types of flap can be harvested based on the different composition. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.01.019DOI Listing
January 2019

Exploring the Human Microbiome: The Potential Future Role of Next-Generation Sequencing in Disease Diagnosis and Treatment.

Front Immunol 2018 7;9:2868. Epub 2019 Jan 7.

Department of Plant Production, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia.

The interaction between the human microbiome and immune system has an effect on several human metabolic functions and impacts our well-being. Additionally, the interaction between humans and microbes can also play a key role in determining the wellness or disease status of the human body. Dysbiosis is related to a plethora of diseases, including skin, inflammatory, metabolic, and neurological disorders. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02868
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http://dx.doi.org/10.3389/fimmu.2018.02868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330296PMC
January 2019
3 Reads

Platelet rich plasma hydrogels promote in vitro and in vivo angiogenic potential of adipose-derived stem cells.

Acta Biomater 2019 Jan 18. Epub 2019 Jan 18.

U.S. Army Institute of Surgical Research, Combat Trauma and Burn Injury Research, JBSA Fort Sam Houston, TX, USA. Electronic address:

Despite great advances in skin wound care utilizing grafting techniques, the resulting severe scarring, deformity and ineffective vascularization remains a challenge. Alternatively, tissue engineering of new skin using patient-derived stem cells and scaffolding materials promises to greatly increase the functional and aesthetic outcome of skin wound healing. This work focused on the optimization of a polyethylene glycol modified (PEGylated) platelet-rich plasma (PRP) hydrogel for the protracted release of cytokines, growth factors, and signaling molecules and also the delivery of a provisional physical framework for stem cell angiogenesis. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.039DOI Listing
January 2019
3 Reads

Innate and Innate-Like Immune System in Hypertension and Vascular Injury.

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Lady Davis Institute for Medical Research, 3755 Côte-Ste-Catherine Rd, Montreal, Quebec, H3T 1E2, Canada.

Purpose Of Review: To describe the important role played by innate and innate-like immunity in the pathophysiology of hypertension and vascular injury.

Recent Findings: Innate immune cells, such as neutrophils, dendritic cells, myeloid-derived suppressor cells, and monocytes/macrophages and innate lymphoid cells such as natural killer cells and unconventional T lymphocytes like γδ T cells contribute to hypertensive mechanisms by priming adaptive immune cells, leading to the triggering of vascular inflammation and blood pressure elevation or alternatively protecting against vascular injury. Specifically, monocyte/macrophages and γδ T cells seem to play a crucial role in the initiation of hypertension via regulation of adaptive immunity. Read More

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http://dx.doi.org/10.1007/s11906-019-0907-1DOI Listing
January 2019
1 Read

Predicting Skin Permeability by Means of Computational Approaches: Reliability and Caveats in Pharmaceutical Studies.

J Chem Inf Model 2019 Feb 5. Epub 2019 Feb 5.

Department of Clinical and Pharmaceutical Sciences , University of Hertfordshire , AL10 9AB Hatfield , United Kingdom.

The skin is the main barrier between the internal body environment and the external one. The characteristics of this barrier and its properties are able to modify and affect drug delivery and chemical toxicity parameters. Therefore, it is not surprising that permeability of many different compounds has been measured through several in vitro and in vivo techniques. Read More

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http://dx.doi.org/10.1021/acs.jcim.8b00934DOI Listing
February 2019
3 Reads

Advanced of Lipid based Nanocarriers and Combination Application with Physical Penetration Technique.

Curr Drug Deliv 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032. China.

On account of the advantages of transdermal delivery and the application situation of transcutaneous technology in transdermal delivery, the article critically comments nanosystems as permeation enhancement model. Nanosystems possess great potential for transcutaneous drug delivery. This review focuses on recent advances in lipid based nanocarriers, including liposome, transfersomes, ethosomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and combination application of the lipid based nanocarriers with microneedle, iontophoresis, electroporation and sonophoresis in the field for the development of the transdermal drug delivery system. Read More

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http://www.eurekaselect.com/169129/article
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http://dx.doi.org/10.2174/1567201816666190118125427DOI Listing
January 2019
5 Reads

Diagnosis and Management of Cutaneous Psoriasis: A Review.

Adv Skin Wound Care 2019 Feb;32(2):58-69

Alisa Brandon, MSc • Medical Student • University of Toronto • Toronto, Ontario, Canada Asfandyar Mufti, MD • Dermatology Resident • University of Toronto • Toronto, Ontario, Canada R. Gary Sibbald, DSc (Hons), MD, MEd, BSc, FRCPC (Med Derm), ABIM, FAAD, MAPWCA • Professor • Medicine and Public Health • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course and Masters of Science in Community Health (Prevention and Wound Care) • Dalla Lana Faculty of Public Health • University of Toronto • Past President • World Union of Wound Healing Societies • Editor-in-Chief • Advances in Skin and Wound Care • Philadelphia, Pennsylvania.

General Purpose: To provide information about the diagnosis and management of cutaneous psoriasis.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After completing this continuing education activity, the provider should be better able to: ABSTRACT: Psoriasis is a chronic inflammatory disease that is characterized by plaque, inverse, guttate, pustular, and erythrodermic variants. Read More

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http://dx.doi.org/10.1097/01.ASW.0000550592.08674.43DOI Listing
February 2019
3 Reads
1.634 Impact Factor

Online "Versus" Print: No More an Either/Or.

Adv Skin Wound Care 2019 Feb;32(2):53

Elizabeth A. Ayello, PhD, RN, CWON, ETN, MAPWCA, FAAN, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Faculty, Excelsior College School of Nursing, Albany, New York; and President, World Council of Enterostomal Therapists, President, Ayello Harris & Associates, Inc, Copake, New York, President (1999) National Pressure Ulcer Advisory Panel. R. Gary Sibbald, MD, DSc (Hons), MEd, BSc, FRCPC (Med Derm), FAAD, MAPWCA, JM, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Professor, Medicine and Public Health, University of Toronto, Toronto, Ontario, Canada; Director, International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care), Dalla Lana Faculty of Public Health, University of Toronto; and President (2008-2012), World Union of Wound Healing Societies.

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http://dx.doi.org/10.1097/01.ASW.0000552821.84096.6bDOI Listing
February 2019
4 Reads

Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions".

J Allergy Clin Immunol 2019 Jan 9. Epub 2019 Jan 9.

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.

Atopic dermatitis (AD) affects up to 20% of children worldwide and is an increasing public health problem, particularly in developed countries. Although AD in infants and young children can resolve, there is a well-recognized increased risk of sequential progression from AD to other atopic diseases, including food allergy (FA), allergic rhinitis, allergic asthma, and allergic rhinoconjunctivitis, a process referred to as the atopic march. The mechanisms underlying the development of AD and subsequent progression to other atopic comorbidities, particularly FA, are incompletely understood and the subject of intense investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193001
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http://dx.doi.org/10.1016/j.jaci.2019.01.003DOI Listing
January 2019
15 Reads

Therapeutic applications of Peptides against Zika Virus: A Review.

Curr Med Chem 2019 Jan 10. Epub 2019 Jan 10.

Department of Chemistry, Deshbandhu College, University of Delhi, Delhi-110019. India.

Zika virus (ZIKV) belongs to the class of flavivirus that can be transmitted by Aedes mosquitoes. The number of Zika virus caused cases of acute infections, neurological disorders and congenital microcephaly are rapidly growing and therefore, in 2016 the World Health Organization declared a global "Public Health Emergency of International Concern". Anti-ZIKV therapeutic and vaccine development strategies are growing worldwide in recent years, however, no specific and safe treatment is available till date to save the human life. Read More

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http://dx.doi.org/10.2174/0929867326666190111115132DOI Listing
January 2019
4 Reads

Tissue-resident lymphocytes: from adaptive to innate immunity.

Cell Mol Immunol 2019 Jan 11. Epub 2019 Jan 11.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8 memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of noncirculating memory T and NK cells that remain resident in the peripheral tissues, termed tissue-resident memory T (T) cells and tissue-resident NK (trNK) cells, observed in various organs owing to improved techniques. Read More

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http://dx.doi.org/10.1038/s41423-018-0192-yDOI Listing
January 2019
2 Reads

Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population.

Eur J Pharm Biopharm 2019 Mar 8;136:48-69. Epub 2019 Jan 8.

School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Electronic address:

Transdermal drug delivery offers several attractive advantages over the traditional oral and parenteral routes. Particularly, in case of paediatric patients, it helps to overcome the issues specific to this population, such as difficulty in swallowing and palatability of oral medicines as well as fear and pain associated with needles. However, due to the formidable barrier characteristic of the stratum corneum, it fails in the effective systemic delivery of broad range of therapeutic molecules, especially macromolecules and genetic material. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.01.005DOI Listing
March 2019
2 Reads

Recent advances in understanding and managing rosacea.

F1000Res 2018 3;7. Epub 2018 Dec 3.

Department of Dermatology and Venereology, Hamad Medical Corporation, Doha, Qatar.

Rosacea is a common chronic inflammatory skin disease of the central facial skin and is of unknown origin. Currently, two classifications of rosacea exist that are based on either "preformed" clinical subtypes (erythematotelangiectatic, papulopustular, phymatous, and ocular) or patient-tailored analysis of the presented rosacea phenotype. Rosacea etiology and pathophysiology are poorly understood. Read More

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https://f1000research.com/articles/7-1885/v1
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http://dx.doi.org/10.12688/f1000research.16537.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281021PMC
December 2018
5 Reads

Vitamin D: part II; cod liver oil, ultraviolet radiation, and eradication of rickets.

Int Orthop 2019 Jan 9. Epub 2019 Jan 9.

Hôpital Henri Mondor, 94010, Creteil, France.

Purpose: After Glisson's description of rickets, it took two centuries to realize that rickets was due to the absence of antirachitic nutrients in the diet or lack exposure of the skin to ultraviolet rays. This bone disease caused by vitamin D deficiency was one of the most common diseases of children 100 years ago. This paper explores how the definition, diagnosis, and treatment of rickets shifted in the first decades of the twentieth century. Read More

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http://dx.doi.org/10.1007/s00264-019-04288-zDOI Listing
January 2019
4 Reads

Neurological Complications of Sjögren's Syndrome: Diagnosis and Management.

Curr Treatm Opt Rheumatol 2017 Dec 24;3(4):275-288. Epub 2017 Oct 24.

School of Medicine and Public Health, University of Wisconsin, Madison, USA.

Opinion Statement:

Purpose Of Review: Neurologic disease is a common extraglandular manifestation of Sjögren's syndrome (SS), the study of which has been hampered both by the lack of uniform definitions for specific neurologic complications and by the imprecision of the tools used to diagnose SS. There is a great need to develop consensus criteria for classifying these varied neurologic manifestations, as has been done in systemic lupus erythematosus (SLE) "Arthritis and rheumatism 42:599-608, 1999". SS patients with certain forms of neurologic involvement, such as small fiber neuropathy and sensory ataxic ganglionopathy, frequently lack anti-SSA and anti-SSB antibodies and other serologic abnormalities. Read More

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http://dx.doi.org/10.1007/s40674-017-0076-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322693PMC
December 2017
12 Reads

Cellular signaling in pseudoxanthoma elasticum: an update.

Cell Signal 2019 Mar 4;55:119-129. Epub 2019 Jan 4.

Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Belgium. Electronic address:

Pseudoxanthoma elasticum is an autosomal recessive genodermatosis with variable expression, due to mutations in the ABCC6 or ENPP1 gene. It is characterized by elastic fiber mineralization and fragmentation, resulting in skin, eye and cardiovascular symptoms. Significant advances have been made in the last 20 years with respect to the phenotypic characterization and pathophysiological mechanisms leading to elastic fiber mineralization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08986568183031
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http://dx.doi.org/10.1016/j.cellsig.2018.12.009DOI Listing
March 2019
2 Reads

Negative Pressure Wound Therapy with Instillation and Dwell for the Management of a Complex Burn: A Case Report and Review of the Literature.

Cureus 2018 Oct 29;10(10):e3514. Epub 2018 Oct 29.

Plastic and Reconstructive Surgery, The University of Texas Medical Branch, Galveston, USA.

Research over the last 50 years has led to significant improvements in outcomes for burn victims. Advances in infection control, attenuation of the hypermetabolic response, and new improved surgical approaches have led to decreased morbidity and mortality. Early wound excision eliminates the devitalized tissue, which is the main reservoir for pathogen propagation. Read More

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http://dx.doi.org/10.7759/cureus.3514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314793PMC
October 2018
8 Reads

Recent advances in understanding ( ) in acne.

F1000Res 2018 19;7. Epub 2018 Dec 19.

Department of Dermatology, Andreas Syggros Hospital, University of Athens, Athens, Greece.

The skin commensal , recently renamed , along with the other major pathophysiological factors of increased seborrhea, hyperkeratinization of the pilosebaceous unit, and inflammation, has long been implicated in the pathogenesis of acne. Recent advances have contributed to our understanding of the role of in acne. Although there are no quantitative differences in of the skin of patients with acne compared with controls, the phylogenic groups display distinct genetic and phenotypic characteristics, biofilms are more frequent in acne, and different phylotypes may induce distinct immune responses in acne. Read More

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https://f1000research.com/articles/7-1953/v1
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http://dx.doi.org/10.12688/f1000research.15659.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305227PMC
December 2018
6 Reads