191 results match your criteria Advances in Pharmacological Sciences [Journal]


Nutraceuticals Inspiring the Current Therapy for Lifestyle Diseases.

Adv Pharmacol Sci 2019 14;2019:6908716. Epub 2019 Jan 14.

Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, India.

Nutraceuticals are the pharmaceutically blended products that possess both nutritional as well as the medicinal value. Such a product is designed to improve the physical health, fight against day-to-day challenges such as stress, increase longevity, etc. Nowadays, emphasis is given to those herbs which are used as food and medicine due to its greater acceptance. Read More

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http://dx.doi.org/10.1155/2019/6908716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348880PMC
January 2019

Antimicrobial Activity Screening of Ethanol Extract of and Investigation of Its Biochemical Composition.

Adv Pharmacol Sci 2019 10;2019:3201458. Epub 2019 Jan 10.

Department of Biology, Faculty of Science and Arts, Kastamonu University, Kastamonu, Turkey.

The aim of this study was to test antimicrobial activity of ethanol extract of against 22 bacteria and 1 yeast. Also, biochemical composition of the extract was investigated. A wide range of Gram-positive, Gram-negative microorganisms, and multidrug resistant bacteria were selected to test the antimicrobial activity. Read More

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http://dx.doi.org/10.1155/2019/3201458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348916PMC
January 2019

Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice.

Adv Pharmacol Sci 2019 8;2019:7865359. Epub 2019 Jan 8.

Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri, West Bengal 734013, India.

The extracts of different parts of L. are used as antidiabetic remedy in the traditional medicinal systems of different parts of the world. Despite these uses in ethnomedicinal system, the antihyperglycemic potentials of oleander stem (NOSE) and root (NORE) extracts have not been pharmacologically evaluated. Read More

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http://dx.doi.org/10.1155/2019/7865359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341266PMC
January 2019
1 Read

Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines.

Adv Pharmacol Sci 2019 3;2019:7943481. Epub 2019 Jan 3.

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Depression is currently recognized as a crucial problem in everyday clinical practice, in light of ever-increasing rates of prevalence, as well as disability, morbidity, and mortality related to this disorder. Currently available antidepressant drugs are notoriously problematic, with suboptimal remission rates and troubling side-effect profiles. Their mechanisms of action focus on the monoamine hypothesis for depression, which centers on the disruption of serotonergic, noradrenergic, and dopaminergic neurotransmission in the brain. Read More

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http://dx.doi.org/10.1155/2019/7943481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335777PMC
January 2019

Total Phenolic Content and Antioxidant and Antibacterial Activities of .

Adv Pharmacol Sci 2019 2;2019:7428593. Epub 2019 Jan 2.

Faculty of Applied Sciences, Universiti Teknologi MARA, 94300 Kota Samarahan, Sarawak, Malaysia.

Different solvent extracts of leaves were evaluated for total phenolic content (TPC) and antioxidant activities based on the Folin-Ciocalteu test and DPPH scavenging activities. The antibacterial activities against four bacteria, namely, Gram-positive bacteria: ATCC 19615 (SP) and ATCC 29737 (SA) and Gram-negative bacteria: ATCC 10536 (EC) and ATCC 9027 (PA), were also performed based on the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. The findings demonstrated that both the methanolic and chloroform extracts displayed strong activities against SA, SP, EC, and PA while the hexane extract demonstrated the weakest activities towards all the four bacteria. Read More

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http://dx.doi.org/10.1155/2019/7428593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334350PMC
January 2019
2 Reads

Therapeutic Properties of Stingless Bee Honey in Comparison with European Bee Honey.

Adv Pharmacol Sci 2018 26;2018:6179596. Epub 2018 Dec 26.

Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Both honeybees ( spp.) and stingless bees ( spp.) produce honeys with high nutritional and therapeutics value. Read More

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https://www.hindawi.com/journals/aps/2018/6179596/
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http://dx.doi.org/10.1155/2018/6179596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327266PMC
December 2018
14 Reads

Tenofovir Disoproxil Fumarate Is Associated with a Set-Point Variation in the Calcium-Parathyroid Hormone-Vitamin D Axis: Results from a German Cohort.

Adv Pharmacol Sci 2018 31;2018:6069131. Epub 2018 Dec 31.

MUC Research, 80335 München, Germany.

Background: Higher levels of parathyroid hormone have been associated with the use of tenofovir disoproxil fumarate (TDF) in people with and without HIV infection. Yet, alterations in calcium levels have never been elucidated in detail.

Objective: To compare the association of parathyroid hormone with serum calcium levels and other markers of calcium and bone metabolism in people living with HIV on TDF- and non-TDF-containing antiretroviral therapy. Read More

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http://dx.doi.org/10.1155/2018/6069131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330833PMC
December 2018

Evaluation of Novel 3-Hydroxyflavone Analogues as HDAC Inhibitors against Colorectal Cancer.

Adv Pharmacol Sci 2018 27;2018:4751806. Epub 2018 Dec 27.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Alteration of epigenetic enzymes is associated with the pathophysiology of colon cancer with an overexpression of histone deacetylase 8 (HDAC8) enzyme in this tissue. Numerous reports suggest that targeting HDAC8 is a viable strategy for developing new anticancer drugs. Flavonols provide a rich source of molecules that are effective against cancer; however, their clinical use is limited. Read More

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http://dx.doi.org/10.1155/2018/4751806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327263PMC
December 2018

Niosome: A Promising Nanocarrier for Natural Drug Delivery through Blood-Brain Barrier.

Adv Pharmacol Sci 2018 11;2018:6847971. Epub 2018 Dec 11.

School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.

Niosomes (the nonionic surfactant vesicles), considered as novel drug delivery systems, can improve the solubility and stability of natural pharmaceutical molecules. They are established to provide targeting and controlled release of natural pharmaceutical compounds. Many factors can influence on niosome construction such as the preparation method, type and amount of surfactant, drug entrapment, temperature of lipids hydration, and the packing factor. Read More

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http://dx.doi.org/10.1155/2018/6847971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311792PMC
December 2018
1 Read

Phenolic Rich Fractions from Mycelium and Fruiting Body of Inhibit Bacterial Pathogens Mediated by Generation of Reactive Oxygen Species and Protein Leakage and Modulate Hypoxic Stress in HEK 293 Cell Line.

Adv Pharmacol Sci 2018 17;2018:6285615. Epub 2018 Dec 17.

Defense Institute of Physiology and Allied Sciences, Delhi 110054, India.

() fungus (Family Ganodermataceae) is widely used as a traditional medicine in China, Japan, and many Asian countries on account of its numerous medicinal properties such as antioxidant, anticancer, antimicrobial, energy enhancing, and immunostimulatory. This broad spectrum of therapeutic effects exhibited by is ascribed to its abundance in several classes of chemical constituents, namely, carbohydrates, flavonoids, minerals, phenolics, proteins, and steroids which possess substantial bioactivities. The aim of the current study was to prepare phenolic rich fractions (PRFs) from aqueous extract of the Indian variety of mycelium and fruiting body. Read More

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https://www.hindawi.com/journals/aps/2018/6285615/
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http://dx.doi.org/10.1155/2018/6285615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311817PMC
December 2018
5 Reads

Mill. (Anil): Plant Profile, Phytochemistry, and Pharmacology Review.

Adv Pharmacol Sci 2018 2;2018:8168526. Epub 2018 Dec 2.

Universidade Federal de Pernambuco (UFPE), Departamento de Bioquímica, Av. Prof. Moraes Rego, 1235-Cidade Universitária, Recife, PE 50670-901, Brazil.

Mill. (Fabaceae) is known as anil or anileira and also with other names, due to the production of a blue pigment, which is commonly used for yarn dyeing. It is distributed in some states of Brazil (Pernambuco, Paraíba, Mato Grosso, São Paulo, Bahia, Pará, and others) and is used in the popular medicine as a febrifuge, antispasmodic, diuretic, abortive, analgesic, purgative, or soothing agent against stomach and urinary problems, jaundice, and ulcers and also as an insecticide. Read More

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https://www.hindawi.com/journals/aps/2018/8168526/
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http://dx.doi.org/10.1155/2018/8168526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305042PMC
December 2018
4 Reads

Use of Flavonoids and Cinnamates, the Main Photoprotectors with Natural Origin.

Adv Pharmacol Sci 2018 28;2018:5341487. Epub 2018 Nov 28.

Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, Av. Cel. Antonio Luiz, 1161, CEP 63105-000, Pimenta, Crato, Ceará, Brazil.

Many pathological problems are initiated by ultraviolet radiation (UVR), such as skin cancer, the most commonly diagnosed cancer worldwide. The UVA (320-400 nm) and UVB (290-320 nm) wavelengths may cause effects such as photoaging, DNA damage, and a series of cellular alterations. The UVA radiation can damage the DNA, oxidize the lipids, and produce dangerous free radicals, which can cause inflammation, modify the gene expression in response to stress, and weaken the skin immune response. Read More

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https://www.hindawi.com/journals/aps/2018/5341487/
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http://dx.doi.org/10.1155/2018/5341487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304211PMC
November 2018
4 Reads

Comparison of Antimicrobial Activity of Cloves from China and Taşköprü, Turkey.

Adv Pharmacol Sci 2018 27;2018:9302840. Epub 2018 Nov 27.

Kastamonu University, Department of Biology, Faculty of Science and Arts, Kastamonu, Turkey.

In this study, antimicrobial activities of two different samples of L. from Turkey (TR) (Taşköprü, Kastamonu, Turkey) and China (CN) were determined. A broad spectrum of Gram-negative and Gram-positive bacteria (17 bacteria) including species of , , , , , , , , and were used for testing antibacterial activity. Read More

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http://dx.doi.org/10.1155/2018/9302840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288568PMC
November 2018
2 Reads

Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders.

Adv Pharmacol Sci 2018 27;2018:3632159. Epub 2018 Nov 27.

Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Lucknow 226028, UP, India.

Neuronal developmental disorder is a class of diseases in which there is impairment of the central nervous system and brain function. The brain in its developmental phase undergoes tremendous changes depending upon the stage and environmental factors. Neurodevelopmental disorders include abnormalities associated with cognitive, speech, reading, writing, linguistic, communication, and growth disorders with lifetime effects. Read More

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http://dx.doi.org/10.1155/2018/3632159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288580PMC
November 2018
4 Reads

HPTLC Analysis of Schrad. and Wendl., a Medicinal Herb.

Adv Pharmacol Sci 2018 8;2018:8546306. Epub 2018 Nov 8.

Department of Botany, Punjabi University, Patiala, Punjab, India.

In the present study, HPTLC is used to detect the presence and amount of triterpenoids and phytosterols in different plant parts (fruit, stem, leaf, and root) of Schrad. and Wendl.; such analysis is done for the first time. Read More

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http://dx.doi.org/10.1155/2018/8546306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250026PMC
November 2018
1 Read

Antidiabetic Effects of the Ethanolic Root Extract of P. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus.

Adv Pharmacol Sci 2018 8;2018:1314941. Epub 2018 Nov 8.

Department of Pharmacology and Therapeutics, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.

Diabetes mellitus has been a menace to mankind from time immemorial. However, a natural product such as P. Beauv (Annonaceae) offers alternative treatment for diabetes mellitus. Read More

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http://dx.doi.org/10.1155/2018/1314941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250042PMC
November 2018
1 Read

Investigation of Antioxidant/Oxidant Status and Antimicrobial Activities of .

Authors:
Mustafa Sevindik

Adv Pharmacol Sci 2018 1;2018:1718025. Epub 2018 Nov 1.

Department of Biology, Faculty of Science, Akdeniz University, Antalya, Turkey.

In the present study, antioxidant and antimicrobial potential of the (Bull.) Fr. mushroom was determined. Read More

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https://www.hindawi.com/journals/aps/2018/1718025/
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http://dx.doi.org/10.1155/2018/1718025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236708PMC
November 2018
7 Reads

Simultaneous Determination of Phenolic Compounds in (Forssk.) Decne. by Using High-Performance Liquid Chromatography (HPLC-DAD-UV).

Adv Pharmacol Sci 2018 21;2018:9604972. Epub 2018 Oct 21.

Department of Botany, Punjabi University, Patiala 147002, Punjab, India.

During the present study, an endeavor has been made to produce a simple, rapid, and simultaneous method for determination of phenolic compounds by using high-performance liquid chromatography in aerial parts of (Forssk.) Decne. collected from the Indian Thar Desert. Read More

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http://dx.doi.org/10.1155/2018/9604972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215595PMC
October 2018
1 Read

Crude Polysaccharides from Okra Pods () Grown in Indonesia Enhance the Immune Response due to Bacterial Infection.

Adv Pharmacol Sci 2018 9;2018:8505383. Epub 2018 Oct 9.

Department of Biology, Faculty of Science and Technology, Airlangga University, Surabaya 60115, Indonesia.

Okra pods were widely consumed by Indonesians to maintain health. The aim of this study was at investigating the potential of crude polysaccharides from okra pods on immune response in mice infected with Thirty male Balb/C mice were divided into six groups: normal control, negative control, and treatment groups (administration of crude polysaccharides at doses of 25, 50, 75, and 100 mg/kg). Crude polysaccharides were administrated for fourteen days. Read More

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https://www.hindawi.com/journals/aps/2018/8505383/
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http://dx.doi.org/10.1155/2018/8505383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198543PMC
October 2018
8 Reads

Updates on the Status of Vitamin D as a Risk Factor for Respiratory Distress Syndrome.

Adv Pharmacol Sci 2018 30;2018:8494816. Epub 2018 Sep 30.

Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

To update the guidelines regarding vitamin D status in respiratory distress syndrome, we reviewed recent human and animal studies on the benefits of vitamin D in respiratory distress. We searched PubMed and ProQuest for studies on the use of vitamin D from 2009 to 2017. The common parameters in these studies included the use of lung tissue, phospholipids, blood, and plasma to assess the effects of vitamin D on respiratory syndrome. Read More

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https://www.hindawi.com/journals/aps/2018/8494816/
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http://dx.doi.org/10.1155/2018/8494816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186338PMC
September 2018
13 Reads

Cytotoxicity of the Aqueous Extract and Organic Fractions from on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29.

Adv Pharmacol Sci 2018 23;2018:3297193. Epub 2018 Aug 23.

Laboratory of Physiology, Genetic and Ethnopharmacology, Faculty of Sciences, Mohammed the First University, PB 717, 60000 Oujda, Morocco.

The toxicity of the aqueous extract of was tested (5 and 10 g/kg) in albino mice. No symptoms of toxicity or mortality were observed. The mice survived being active and healthy during all 14 days of observation. Read More

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https://www.hindawi.com/journals/aps/2018/3297193/
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http://dx.doi.org/10.1155/2018/3297193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126111PMC
August 2018
7 Reads

A Review of Malaysian Medicinal Plants with Potential Anti-Inflammatory Activity.

Adv Pharmacol Sci 2018 9;2018:8603602. Epub 2018 Jul 9.

Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia (UTHM), Hab Pendidikan Tinggi Pagoh, KM 1, Jalan Panchor, 84600 Muar, Johor, Malaysia.

This article aims to provide detailed information on Malaysian plants used for treating inflammation. An extensive search on electronic databases including PubMed, Google Scholar, Scopus, and ScienceDirect and conference papers was done to find relevant articles on anti-inflammatory activity of Malaysian medicinal plants. The keyword search terms used were "inflammation," "Malaysia," "medicinal plants," "mechanisms," "," and ". Read More

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http://dx.doi.org/10.1155/2018/8603602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079619PMC
July 2018
12 Reads

Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs.

Adv Pharmacol Sci 2018 24;2018:4848602. Epub 2018 Jun 24.

Department of Veterinary Preclinical Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.

Doxorubicin (DOX) is a potent anticancer agent with cytotoxic effects which limit its clinical usage. This effect is due to its nonselective nature causing injury to the cells as a result of reactive free oxygen radical's release. Cockleshell-derived calcium carbonate nanoparticle (CS-CaCONP) is a pH-responsive carrier with targeted delivery potentials. Read More

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http://dx.doi.org/10.1155/2018/4848602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035816PMC
June 2018
4 Reads

Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films.

Adv Pharmacol Sci 2018 25;2018:8043837. Epub 2018 Jun 25.

Department of Biology, Temple University, 1900 N. 12th Street, Philadelphia, PA 19122, USA.

Bitter taste is aversive to humans, and many oral medications exhibit a bitter taste. Bitter taste can be suppressed by the use of inhibitors or by masking agents such as sucralose. Another approach is to encapsulate bitter tasting compounds in order to delay their release. Read More

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http://dx.doi.org/10.1155/2018/8043837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036852PMC
June 2018
4 Reads

Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease's Statin Therapy in Men.

Adv Pharmacol Sci 2018 17;2018:4673061. Epub 2018 May 17.

Department of Physiology, Faculty of Natural Sciences and Mathematics, "Ss. Cyril and Methodius" University, Skopje, Macedonia.

Oxidative stress and inflammation contribute to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD), and the control of lipid status by statins may help to stop the progression of NAFLD. We hypothesized that the addition of antioxidant vitamins C and E to atorvastatin therapy is associated with improved serum enzyme antioxidant status. NAFLD-related serum parameters and the activity of antioxidant enzymes, before and after 3 months of treatment, were determined in patients receiving atorvastatin alone or atorvastatin plus antioxidants. Read More

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http://dx.doi.org/10.1155/2018/4673061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985129PMC
May 2018
5 Reads

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities.

Adv Pharmacol Sci 2018 2;2018:9794625. Epub 2018 May 2.

Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde 51240, Turkey.

Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as . This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. Read More

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http://dx.doi.org/10.1155/2018/9794625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954929PMC
May 2018
20 Reads

Antibacterial Activity of Two Flavans from the Stem Bark of .

Adv Pharmacol Sci 2018 30;2018:5870161. Epub 2018 Apr 30.

Applied Chemistry Program, School of Applied Natural Science, Adama Science and Technology University, P.O. Box 1888, Adama, Ethiopia.

Vatke is one of the medicinal plants used traditionally for treatment of intestinal tape worm, dysmenorrheal, bacterial, and fungal infections. Phytochemical screening test of the dichloromethane/methanol (1 : 1) and methanol extracts revealed the presence of phenols, alkaloids, tannins, and flavonoids whereas terpenoids, glycoside, and phytosterols were absent. Silica gel column chromatographic separation of the methanol extract afforded 3,5,7,3',4'-pentahydroxyflavan, named epicatechin (), along with a close flavan derivative (). Read More

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https://www.hindawi.com/journals/aps/2018/5870161/
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http://dx.doi.org/10.1155/2018/5870161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952501PMC
April 2018
20 Reads

Efficacy of , , and Cream on the Skin Wound Infected with MRSA.

Adv Pharmacol Sci 2018 19;2018:4670569. Epub 2018 Apr 19.

Faculty of Veterinary Medicine, University of Wijaya Kusuma Surabaya, East Java, Indonesia.

The tropical area has a lot of herbal medicines such as (AV), (AC), and (SM). All the three have a unique potential effect as an antibacterial and wound-healing promoter. The aim of this study is to explore the role of AV, AC, and SM on the skin wound infected with methicillin-resistant (MRSA). Read More

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http://dx.doi.org/10.1155/2018/4670569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933069PMC
April 2018
6 Reads

Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One.

Adv Pharmacol Sci 2018 1;2018:6042602. Epub 2018 Apr 1.

PharmacodynamyResearch Team PRT, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, BP 6203, Rabat, Morocco.

The objective of our work is to make a pharmacological study of molecules derived from 4-phenyl-1,5-benzodiazepin-2-one carrying long chains so that they have a structure similar to surfactants, with the benzodiazepine as a hydrophilic head and a carbon chain as a hydrophobic tail. First, we studied the acute toxicity of the above mentioned 4-phenyl-1,5-benzodiazepin-2-one derivatives. This study was conducted according to OECD 423 guidelines in female mice and revealed that these compounds are nontoxic. Read More

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https://www.hindawi.com/journals/aps/2018/6042602/
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http://dx.doi.org/10.1155/2018/6042602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902104PMC
April 2018
23 Reads

Studies on the Dual Cytotoxicity and Antioxidant Properties of Extracts and Its Main Constituent Berberine.

Adv Pharmacol Sci 2018 8;2018:3018498. Epub 2018 Jan 8.

Laboratory of Biological Engineering, Natural Substances, Cellular and Molecular Immuno-Pharmacology Team, Immunobiology of Cancer Cells, Faculty of Sciences and Technology of Beni Mellal, P.O. Box 523, 23000 Beni-Mellal, Morocco.

The present study attempts to investigate the cytotoxic activity of ethanol and ethyl acetate extracts of the Moroccan and its major component berberine, together with exploring their antioxidant properties. It also consists of studying the combination effect of berberine and S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO) donor, against the human breast adenocarcinoma cell line (MCF-7). Using the MTT assay, we report a differential cytotoxic effect of ethanol and ethyl acetate extracts since the ethanol extract is more cytotoxic than the ethyl acetate one, with IC = 3. Read More

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http://dx.doi.org/10.1155/2018/3018498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817274PMC
January 2018
25 Reads

Antibacterial and Antioxidant Compounds from the Flower Extracts of .

Adv Pharmacol Sci 2018 20;2018:4083736. Epub 2018 Mar 20.

Chemistry Department, Applied Natural Sciences, Adama Science and Technology University, Adama, Ethiopia.

is traditionally used in Ethiopia to treat various diseases. This prompted us to isolate bioactive compounds from the flowers of this plant. The CHCl extract after silica gel column chromatography has led to the isolation of two compounds identified as tricosane and vernolide , while the acetone extract furnished isorhamnetin and luteolin . Read More

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http://dx.doi.org/10.1155/2018/4083736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884303PMC
March 2018
3 Reads

Downregulation of Thromboxane A Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery.

Adv Pharmacol Sci 2017 9;2017:6507048. Epub 2017 Jul 9.

Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.

Thromboxane A (TXA) acts on TXA receptors (TP) to regulate renal artery blood flow and subsequently contributes to the pathogenesis of renal ischemia. The present study was designed to examine if nuclear factor-kappaB (NF-B) signaling pathway is involved in the downregulation of TP receptors in rat renal artery. Rat renal artery segments were organ cultured for 6 or 24 h. Read More

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http://dx.doi.org/10.1155/2017/6507048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523459PMC
July 2017
24 Reads

Chemical Composition and Cytotoxic and Antibacterial Activities of the Essential Oil of Palau Grown in Morocco.

Adv Pharmacol Sci 2017 12;2017:7801924. Epub 2017 Jun 12.

Laboratory of Biological Engineering, Natural Substances, Cellular and Molecular Immuno-Pharmacology, Immunobiology of Cancer Cells Cluster, Faculty of Science and Technology, Sultan Moulay Slimane University, Beni Mellal, Morocco.

The aim of this work is to investigate the cytotoxic and antibacterial effects of the essential oils of Palau, harvested in different regions of Morocco. The chemical profile was established using gas chromatography-mass spectrometry analysis. The cytotoxic activity against P815, MCF7, and VERO cell lines as well as the normal human peripheral blood mononuclear cells (PBMCs) was evaluated using the MTT assay. Read More

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http://dx.doi.org/10.1155/2017/7801924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485486PMC
June 2017
43 Reads

The Effects of Flower Extract on Skin Injuries Induced by Burn in Rats.

Adv Pharmacol Sci 2017 19;2017:3059745. Epub 2017 Jan 19.

Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.

. We compared the efficacy of (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. . Read More

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http://dx.doi.org/10.1155/2017/3059745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288512PMC
January 2017
20 Reads

Neuroprotection in Glaucoma: Old and New Promising Treatments.

Adv Pharmacol Sci 2017 17;2017:4320408. Epub 2017 Oct 17.

Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, Rome, Italy.

Glaucoma is a major global cause of blindness, but the molecular mechanisms responsible for the neurodegenerative damage are not clear. Undoubtedly, the high intraocular pressure (IOP) and the secondary ischemic and mechanical damage of the optic nerve have a crucial role in retinal ganglion cell (RGC) death. Several studies specifically analyzed the events that lead to nerve fiber layer thinning, showing the importance of both intra- and extracellular factors. Read More

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http://dx.doi.org/10.1155/2017/4320408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664381PMC
October 2017

Phytochemical and Pharmacological Review of (Lindl.) Schlechter.

Adv Pharmacol Sci 2017 15;2017:3026370. Epub 2017 Oct 15.

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Ethnopharmacological Relevance: is a scrambling thin-stemmed shrub found in Africa. Traditionally in West Africa, it is employed in the treatment of malaria, diarrhea, and respiratory conditions. This review discusses the traditional importance as well as the phytochemical, ethnomedical, pharmacological, and toxicological importance of this plant. Read More

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http://dx.doi.org/10.1155/2017/3026370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661077PMC
October 2017
4 Reads

Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats.

Adv Pharmacol Sci 2016 20;2016:3094783. Epub 2016 Nov 20.

Department of Pharmacology, University of the Free State, P.O. Box 339, Bloemfontein 9300, South Africa.

The aim of this study was to illustrate the initial subclinical drug-induced liver injury and the associated adaptive immune response by monitoring for the changes in plasma IL-2, IL-10, and some cytochrome P450 activity during chronic administration of nevirapine (NVP), isoniazid (INH), and paracetamol (PAR) in rats without clinical hepatotoxicity. Male Sprague-Dawley (SD) rats were divided into four groups (saline (S), NVP, INH, and PAR) of 25 animals each. The drugs were administered daily for 42 days at therapeutic doses (NVP 200 mg/kg, PAR 500 mg/kg, and INH 20 mg/kg) to the respective groups by oral gavage and five rats per group were sacrificed weekly. Read More

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http://dx.doi.org/10.1155/2016/3094783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136381PMC
November 2016
14 Reads

The Methanolic Extract from L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K Channel as Antinociceptive Mechanism.

Adv Pharmacol Sci 2016 12;2016:3790860. Epub 2016 Oct 12.

Department of Pharmacy, Stamford University Bangladesh, 51 Shiddheswari Road, Dhaka 1217, Bangladesh.

L. is a perennial shrub, belonging to the family Rutaceae. Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation. Read More

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http://dx.doi.org/10.1155/2016/3790860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080466PMC
October 2016
16 Reads

Thrombus Degradation by Fibrinolytic Enzyme of Stenotrophomonas sp. Originated from Indonesian Soybean-Based Fermented Food on Wistar Rats.

Adv Pharmacol Sci 2016 21;2016:4206908. Epub 2016 Aug 21.

Faculty of Biotechnology, Atmajaya University, Jalan Jenderal Sudirman 51, Jakarta Selatan 12930, Indonesia; Department of Food Science and Technology, Faculty of Agricultural Engineering and Technology, Bogor Agricultural University, Bogor 16002, Indonesia.

Objective. To evaluate thrombus degrading effect of a fibrinolytic enzyme from food origin Stenotrophomonas sp. of Indonesia. Read More

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http://dx.doi.org/10.1155/2016/4206908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011239PMC
September 2016
15 Reads

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties.

Adv Pharmacol Sci 2016 11;2016:3040724. Epub 2016 Jul 11.

Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. Read More

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http://dx.doi.org/10.1155/2016/3040724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958467PMC
August 2016
14 Reads

MDMA Impairs Response to Water Intake in Healthy Volunteers.

Adv Pharmacol Sci 2016 14;2016:2175896. Epub 2016 Jun 14.

Addiction and Pharmacology Research Laboratory, Friends Research Institute, Baltimore, MD 21201, USA.

Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In Study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic inverse agonist prazosin, used as a positive control to release antidiuretic hormone (ADH). Read More

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http://dx.doi.org/10.1155/2016/2175896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923534PMC
July 2016
10 Reads

A Review on Medicinal Properties of Orientin.

Adv Pharmacol Sci 2016 19;2016:4104595. Epub 2016 May 19.

Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, 31900 Kampar, Perak, Malaysia.

Medicinal plants continue to play an important role in modern medications and healthcare as consumers generally believe that most of them cause fewer or milder adverse effects than the conventional modern medicines. In order to use the plants as a source of medicinal agents, the bioactive compounds are usually extracted from plants. Therefore, the extraction of bioactive compounds from medicinal plants is a crucial step in producing plant-derived drugs. Read More

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http://dx.doi.org/10.1155/2016/4104595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889806PMC
June 2016
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Radical-Scavenging Activity and Ferric Reducing Ability of Juniperus thurifera (L.), J. oxycedrus (L.), J. phoenicea (L.) and Tetraclinis articulata (L.).

Adv Pharmacol Sci 2016 16;2016:6392656. Epub 2016 May 16.

Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, BP 6203, Rabat-Instituts, Rabat, Morocco.

Objective. The aim of this work is to study and compare the antioxidant properties and phenolic contents of aqueous leaf extracts of Juniperus thurifera, Juniperus oxycedrus, Juniperus Phoenicea, and Tetraclinis articulata from Morocco. Methods. Read More

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http://dx.doi.org/10.1155/2016/6392656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884791PMC
June 2016
35 Reads

Review of Anti-Inflammatory Herbal Medicines.

Adv Pharmacol Sci 2016 10;2016:9130979. Epub 2016 May 10.

School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies. Read More

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http://dx.doi.org/10.1155/2016/9130979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877453PMC
June 2016
11 Reads

Cytotoxicity and Antiproliferative Activity Assay of Clove Mistletoe (Dendrophthoe pentandra (L.) Miq.) Leaves Extracts.

Adv Pharmacol Sci 2016 23;2016:3242698. Epub 2016 Mar 23.

Department of Veterinary Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor 16680, Indonesia.

Clove mistletoe (Dendrophthoe pentandra (L.) Miq.) is a semiparasitic plant that belongs to Loranthaceae family. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821920PMC
April 2016
19 Reads

The Influence of Palatable Diets in Reward System Activation: A Mini Review.

Adv Pharmacol Sci 2016 20;2016:7238679. Epub 2016 Mar 20.

Pharmacology of Pain and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil; Graduate Program in Biological Sciences-Physiology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil.

The changes in eating patterns that have occurred in recent decades are an important cause of obesity. Food intake and energy expenditure are controlled by a complex neural system involving the hypothalamic centers and peripheral satiety system (gastrointestinal and pancreatic hormones). Highly palatable and caloric food disrupts appetite regulation; however, palatable foods induce pleasure and reward. Read More

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http://dx.doi.org/10.1155/2016/7238679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818794PMC
April 2016
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Pharmacokinetics of Immediate and Sustained Release Cephalexin Administered by Different Routes to Llamas (Lama glama).

Adv Pharmacol Sci 2016 9;2016:4621039. Epub 2016 Mar 9.

Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Chorroarín 280, 1427 Ciudad Autónoma de Buenos Aires, Argentina.

We investigate the pharmacokinetics of two different cephalexin formulations administered to llamas by the intravenous (IV), intramuscular (IM), and subcutaneous (SC) routes, the minimum inhibitory concentration (MIC) of cephalexin against some Escherichia coli and staphylococci isolated from llamas, and we apply the PK/PD modelling approach, so that effective dosage recommendations for this species could be made. Six llamas received immediate (10 mg/kg, IV, IM, and SC) and sustained (8 mg/kg IM, SC) release cephalexin. Pharmacokinetic parameters were calculated by noncompartmental approach. Read More

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http://dx.doi.org/10.1155/2016/4621039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804046PMC
April 2016
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Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study.

Adv Pharmacol Sci 2016 6;2016:4608979. Epub 2016 Mar 6.

Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.

The present study was designed to investigate the role of combined administration of Ramipril and Candesartan against in vitro myocardial ischemic reperfusion injury in rat. Male Wistar albino rats were divided into five groups (n = 6) and treated with saline (10 mL/kg), Ramipril (2 mg/kg), Candesartan (1 mg/kg), and the combination of both drugs, respectively 24 h before induction of global ischemia (5 min of stabilization, 9 min of global ischemia, and 12 min of reflow). Combination of Ramipril and Candesartan when compared to the monotherapy significantly increased the levels of superoxide dismutase, reduced glutathione, catalase, and nitric oxide and decreased the levels of thiobarbituric acid reactive substances. Read More

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http://dx.doi.org/10.1155/2016/4608979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799827PMC
April 2016
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Gender Difference in Renal Blood Flow Response to Angiotensin II Administration after Ischemia/Reperfusion in Rats: The Role of AT2 Receptor.

Adv Pharmacol Sci 2016 10;2016:7294942. Epub 2016 Mar 10.

Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran; Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745, Iran; Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan 81546, Iran.

Background. Renal ischemia/reperfusion (I/R) is one of the major causes of kidney failure, and it may interact with renin angiotensin system while angiotensin II (Ang II) type 2 receptor (AT2R) expression is gender dependent. We examined the role of AT2R blockade on vascular response to Ang II after I/R in rats. Read More

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http://dx.doi.org/10.1155/2016/7294942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806269PMC
April 2016
14 Reads

Cytotoxic Activity of Holothuria leucospilota Extract against Leishmania infantum In Vitro.

Adv Pharmacol Sci 2016 28;2016:8195381. Epub 2016 Feb 28.

Department of Medical Parasitology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Leishmaniasis is a tropical parasitic infection. The resistance and toxicity issues are the major complications and remain significant consequences related to the treatment of leishmaniasis with the recent and classical drugs. Thus there is an immediate requirement to develop new compounds for the treatment of this protozoan disease. Read More

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http://dx.doi.org/10.1155/2016/8195381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789066PMC
March 2016
17 Reads