202 results match your criteria Advances in Pharmacological Sciences [Journal]


GRP78/BIP/HSPA5 as a Therapeutic Target in Models of Parkinson's Disease: A Mini Review.

Adv Pharmacol Sci 2019 5;2019:2706783. Epub 2019 Mar 5.

Department of Medical Biosciences, University of the Western Cape, Robert Sobukwe Road, Private Bag X17, Bellville 7535, South Africa.

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by selective loss of dopamine neurons in the substantia nigra pars compacta of the midbrain. Reports from postmortem studies in the human PD brain, and experimental PD models reveal that endoplasmic reticulum (ER) stress is implicated in the pathogenesis of PD. In times of stress, the unfolded or misfolded proteins overload the folding capacity of the ER to induce a condition generally known as ER stress. Read More

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http://dx.doi.org/10.1155/2019/2706783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425347PMC
March 2019
1 Read

Novelty of Bioengineered Iron Nanoparticles in Nanocoated Surgical Cotton: A Green Chemistry.

Adv Pharmacol Sci 2019 3;2019:9825969. Epub 2019 Feb 3.

Department of Microbiology, School of Science, RK University, Rajkot 360020, Gujarat, India.

The current focus of nanotechnology is to develop environmentally safe methodologies for the formulation of nanoparticles. The phytochemistry of inspired us to utilize it for the synthesis of iron nanoparticles. GC-MS analysis revealed the phytochemical profile of ginger. Read More

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http://dx.doi.org/10.1155/2019/9825969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409075PMC
February 2019
1 Read

- and -Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents.

Adv Pharmacol Sci 2019 11;2019:9080279. Epub 2019 Feb 11.

Department of Microbiology, School of Science, RK University, Kasturbadham, Rajkot 360020, India.

Rapid, eco-friendly, and cost-effective one-pot synthesis of copper nanoparticles is reported here using medicinal plants like and . Aqueous extracts of flower, leaf, and stem of and leaves of were prepared which could effectively reduce Cu ions to CuNPs within 5 h at 100°C which were further characterized using UV-visible spectroscopy, field emission scanning electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy, dynamic light scattering, X-ray diffraction, and Fourier-transform infrared spectroscopy. Further, the CuNPs were checked for antidiabetic activity using porcine pancreatic -amylase and -glucosidase inhibition followed by evaluation of mechanism using circular dichroism spectroscopy. Read More

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http://dx.doi.org/10.1155/2019/9080279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388358PMC
February 2019

Analysis of Osteoblast Culture on Scaffolds for Future Bone Regeneration Purposes in Dentistry.

Adv Pharmacol Sci 2019 6;2019:5420752. Epub 2019 Feb 6.

Department of Chemistry, School of Sciences, Pontificia Universidad Javeriana, Bogotá, Colombia.

One of the main focuses of tissue engineering is to search for tridimensional scaffold materials, complying with nature's properties for tissue regeneration. Determining material biocompatibility is a fundamental step in considering its use. Therefore, the purpose of this study was to analyze osteoblast cell adhesion and viability on different materials to determine which was more compatible for future bone regeneration. Read More

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http://dx.doi.org/10.1155/2019/5420752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381563PMC
February 2019

Effect of "DXB-2030," a Polyherbal Formulation, on Experimental Polycystic Ovary Syndrome Associated with Hyperandrogenism.

Adv Pharmacol Sci 2019 3;2019:8272850. Epub 2019 Feb 3.

Chief Scientific Officer, R&D Center, The Himalaya Drug Company, Bangalore, Karnataka, India.

The objective of the present study was to evaluate "DXB-2030," a polyherbal combination of , , , , and extracts in an experimental model of testosterone propionate (TP), induced polycystic ovary syndrome (PCOS) in female rats. Thirty animals were divided into 3 groups of 10 each; group 1 served as normal control; group 2 was administered with TP and served as positive control; along with TP, group 3 was treated with "DXB-2030" at a dose of 100 mg/kg p.o. Read More

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http://dx.doi.org/10.1155/2019/8272850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378078PMC
February 2019
2 Reads

Allergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation.

Adv Pharmacol Sci 2019 3;2019:6097349. Epub 2019 Feb 3.

Department of Pharmacology, School of Medical Sciences, College of Health & Allied Sciences, University of Cape Coast, Cape Coast, Ghana.

Bergapten (5-methoxypsoralen, 5-MOP) is a plant-derived furocoumarin with demonstrated anti-inflammatory action. The present study investigated its effects on allergic inflammation in two related pathways of mast cell degranulation. Compound 48/80 and lipopolysaccharide (LPS) were used to activate the IgE-independent pathway while bovine serum albumin (BSA) was used as allergen for the IgE-dependent pathway. Read More

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http://dx.doi.org/10.1155/2019/6097349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378071PMC
February 2019
1 Read

Antibacterial Activity of Coumarins and Carbazole Alkaloid from Roots of .

Adv Pharmacol Sci 2019 3;2019:5419854. Epub 2019 Feb 3.

Department of Applied Chemistry, Adama Science and Technology University, P.O.Box 1888, Adama, Ethiopia.

is one of the medicinal plants used traditionally for treatment of parasitic infections, irritation (boils, ringworm, and eczema), flatworm infestations, influenza, abdominal cramps, and constipation. Phytochemical screening test of dichloromethane/methanol (1 : 1) roots extract revealed the presence of flavonoids, phytosterols, coumarins, phenols, alkaloids, tannins, terpenoids, and free reducing sugars and the absence of saponins. Silica gel column chromatographic separation of the dichloromethane/methanol (1 : 1) extract afforded a carbazole alkaloid derivative of heptazoline () and three coumarins (-), including the known coumarins imperatorin () and chalepin (). Read More

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https://www.hindawi.com/journals/aps/2019/5419854/
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http://dx.doi.org/10.1155/2019/5419854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378073PMC
February 2019
6 Reads

Antimutagenic and Synergistic Cytotoxic Effect of Cisplatin and Honey Bee Venom on 4T1 Invasive Mammary Carcinoma Cell Line.

Adv Pharmacol Sci 2019 29;2019:7581318. Epub 2019 Jan 29.

Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.

Introduction: Honey bee venom (HBV) has various biological activities such as the inhibitory effect on several types of cancer. Cisplatin is an old and potent drug to treat most of the cancers. Our aim in the present study was to determine antimutagenic and cytotoxic effects of HBV on mammary carcinoma, exclusively and in combination with cisplatin. Read More

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http://dx.doi.org/10.1155/2019/7581318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374791PMC
January 2019
5 Reads

Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis.

Authors:
Rebecca S Y Wong

Adv Pharmacol Sci 2019 29;2019:5324170. Epub 2019 Jan 29.

Faculty of Medicine, SEGi University, No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia.

Spondyloarthritis or spondyloarthropathy (SpA) is a group of related rheumatic disorders, which presents with axial and nonaxial features, affecting structures within the musculoskeletal system, as well as other bodily systems. Both pharmacological and nonpharmacological therapeutic options are available for SpA. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used as the first-line drugs to treat the disease. Read More

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http://dx.doi.org/10.1155/2019/5324170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374855PMC
January 2019

Role of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Cancer Prevention and Cancer Promotion.

Authors:
Rebecca S Y Wong

Adv Pharmacol Sci 2019 31;2019:3418975. Epub 2019 Jan 31.

Faculty of Medicine, SEGi University, No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia.

The nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed by medical practitioners in many clinical conditions for the symptomatic treatment of pain and fever. Due to their anti-inflammatory properties, these drugs have been investigated for their anticancer effects in numerous studies. This is because chronic inflammation has long been linked to carcinogenesis. Read More

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http://dx.doi.org/10.1155/2019/3418975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374867PMC
January 2019
7 Reads

Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria.

Adv Pharmacol Sci 2019 27;2019:1739868. Epub 2019 Jan 27.

Institute of Science, Nirma University, Ahmedabad-382481, India.

This study investigated antipathogenic efficacy of a polyherbal wound-healing formulation Herboheal against three multidrug-resistant strains of gram-negative bacterial pathogens associated with wound infections. Herboheal was evaluated for its quorum-modulatory potential against three different human-pathogenic bacteria, first through the broth dilution assay and then in the model host . Herboheal at ≥0. Read More

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http://dx.doi.org/10.1155/2019/1739868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369513PMC
January 2019

Nutraceuticals Inspiring the Current Therapy for Lifestyle Diseases.

Adv Pharmacol Sci 2019 14;2019:6908716. Epub 2019 Jan 14.

Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, India.

Nutraceuticals are the pharmaceutically blended products that possess both nutritional as well as the medicinal value. Such a product is designed to improve the physical health, fight against day-to-day challenges such as stress, increase longevity, etc. Nowadays, emphasis is given to those herbs which are used as food and medicine due to its greater acceptance. Read More

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http://dx.doi.org/10.1155/2019/6908716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348880PMC
January 2019
1 Read

Antimicrobial Activity Screening of Ethanol Extract of and Investigation of Its Biochemical Composition.

Adv Pharmacol Sci 2019 10;2019:3201458. Epub 2019 Jan 10.

Department of Biology, Faculty of Science and Arts, Kastamonu University, Kastamonu, Turkey.

The aim of this study was to test antimicrobial activity of ethanol extract of against 22 bacteria and 1 yeast. Also, biochemical composition of the extract was investigated. A wide range of Gram-positive, Gram-negative microorganisms, and multidrug resistant bacteria were selected to test the antimicrobial activity. Read More

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http://dx.doi.org/10.1155/2019/3201458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348916PMC
January 2019

Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice.

Adv Pharmacol Sci 2019 8;2019:7865359. Epub 2019 Jan 8.

Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri, West Bengal 734013, India.

The extracts of different parts of L. are used as antidiabetic remedy in the traditional medicinal systems of different parts of the world. Despite these uses in ethnomedicinal system, the antihyperglycemic potentials of oleander stem (NOSE) and root (NORE) extracts have not been pharmacologically evaluated. Read More

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http://dx.doi.org/10.1155/2019/7865359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341266PMC
January 2019
4 Reads

Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines.

Adv Pharmacol Sci 2019 3;2019:7943481. Epub 2019 Jan 3.

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Depression is currently recognized as a crucial problem in everyday clinical practice, in light of ever-increasing rates of prevalence, as well as disability, morbidity, and mortality related to this disorder. Currently available antidepressant drugs are notoriously problematic, with suboptimal remission rates and troubling side-effect profiles. Their mechanisms of action focus on the monoamine hypothesis for depression, which centers on the disruption of serotonergic, noradrenergic, and dopaminergic neurotransmission in the brain. Read More

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http://dx.doi.org/10.1155/2019/7943481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335777PMC
January 2019

Total Phenolic Content and Antioxidant and Antibacterial Activities of .

Adv Pharmacol Sci 2019 2;2019:7428593. Epub 2019 Jan 2.

Faculty of Applied Sciences, Universiti Teknologi MARA, 94300 Kota Samarahan, Sarawak, Malaysia.

Different solvent extracts of leaves were evaluated for total phenolic content (TPC) and antioxidant activities based on the Folin-Ciocalteu test and DPPH scavenging activities. The antibacterial activities against four bacteria, namely, Gram-positive bacteria: ATCC 19615 (SP) and ATCC 29737 (SA) and Gram-negative bacteria: ATCC 10536 (EC) and ATCC 9027 (PA), were also performed based on the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. The findings demonstrated that both the methanolic and chloroform extracts displayed strong activities against SA, SP, EC, and PA while the hexane extract demonstrated the weakest activities towards all the four bacteria. Read More

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http://dx.doi.org/10.1155/2019/7428593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334350PMC
January 2019
5 Reads

Therapeutic Properties of Stingless Bee Honey in Comparison with European Bee Honey.

Adv Pharmacol Sci 2018 26;2018:6179596. Epub 2018 Dec 26.

Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Both honeybees ( spp.) and stingless bees ( spp.) produce honeys with high nutritional and therapeutics value. Read More

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https://www.hindawi.com/journals/aps/2018/6179596/
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http://dx.doi.org/10.1155/2018/6179596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327266PMC
December 2018
16 Reads

Tenofovir Disoproxil Fumarate Is Associated with a Set-Point Variation in the Calcium-Parathyroid Hormone-Vitamin D Axis: Results from a German Cohort.

Adv Pharmacol Sci 2018 31;2018:6069131. Epub 2018 Dec 31.

MUC Research, 80335 München, Germany.

Background: Higher levels of parathyroid hormone have been associated with the use of tenofovir disoproxil fumarate (TDF) in people with and without HIV infection. Yet, alterations in calcium levels have never been elucidated in detail.

Objective: To compare the association of parathyroid hormone with serum calcium levels and other markers of calcium and bone metabolism in people living with HIV on TDF- and non-TDF-containing antiretroviral therapy. Read More

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http://dx.doi.org/10.1155/2018/6069131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330833PMC
December 2018
2 Reads

Evaluation of Novel 3-Hydroxyflavone Analogues as HDAC Inhibitors against Colorectal Cancer.

Adv Pharmacol Sci 2018 27;2018:4751806. Epub 2018 Dec 27.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Alteration of epigenetic enzymes is associated with the pathophysiology of colon cancer with an overexpression of histone deacetylase 8 (HDAC8) enzyme in this tissue. Numerous reports suggest that targeting HDAC8 is a viable strategy for developing new anticancer drugs. Flavonols provide a rich source of molecules that are effective against cancer; however, their clinical use is limited. Read More

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http://dx.doi.org/10.1155/2018/4751806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327263PMC
December 2018

Niosome: A Promising Nanocarrier for Natural Drug Delivery through Blood-Brain Barrier.

Adv Pharmacol Sci 2018 11;2018:6847971. Epub 2018 Dec 11.

School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.

Niosomes (the nonionic surfactant vesicles), considered as novel drug delivery systems, can improve the solubility and stability of natural pharmaceutical molecules. They are established to provide targeting and controlled release of natural pharmaceutical compounds. Many factors can influence on niosome construction such as the preparation method, type and amount of surfactant, drug entrapment, temperature of lipids hydration, and the packing factor. Read More

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http://dx.doi.org/10.1155/2018/6847971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311792PMC
December 2018
1 Read

Phenolic Rich Fractions from Mycelium and Fruiting Body of Inhibit Bacterial Pathogens Mediated by Generation of Reactive Oxygen Species and Protein Leakage and Modulate Hypoxic Stress in HEK 293 Cell Line.

Adv Pharmacol Sci 2018 17;2018:6285615. Epub 2018 Dec 17.

Defense Institute of Physiology and Allied Sciences, Delhi 110054, India.

() fungus (Family Ganodermataceae) is widely used as a traditional medicine in China, Japan, and many Asian countries on account of its numerous medicinal properties such as antioxidant, anticancer, antimicrobial, energy enhancing, and immunostimulatory. This broad spectrum of therapeutic effects exhibited by is ascribed to its abundance in several classes of chemical constituents, namely, carbohydrates, flavonoids, minerals, phenolics, proteins, and steroids which possess substantial bioactivities. The aim of the current study was to prepare phenolic rich fractions (PRFs) from aqueous extract of the Indian variety of mycelium and fruiting body. Read More

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https://www.hindawi.com/journals/aps/2018/6285615/
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http://dx.doi.org/10.1155/2018/6285615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311817PMC
December 2018
9 Reads

Mill. (Anil): Plant Profile, Phytochemistry, and Pharmacology Review.

Adv Pharmacol Sci 2018 2;2018:8168526. Epub 2018 Dec 2.

Universidade Federal de Pernambuco (UFPE), Departamento de Bioquímica, Av. Prof. Moraes Rego, 1235-Cidade Universitária, Recife, PE 50670-901, Brazil.

Mill. (Fabaceae) is known as anil or anileira and also with other names, due to the production of a blue pigment, which is commonly used for yarn dyeing. It is distributed in some states of Brazil (Pernambuco, Paraíba, Mato Grosso, São Paulo, Bahia, Pará, and others) and is used in the popular medicine as a febrifuge, antispasmodic, diuretic, abortive, analgesic, purgative, or soothing agent against stomach and urinary problems, jaundice, and ulcers and also as an insecticide. Read More

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https://www.hindawi.com/journals/aps/2018/8168526/
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http://dx.doi.org/10.1155/2018/8168526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305042PMC
December 2018
9 Reads

Use of Flavonoids and Cinnamates, the Main Photoprotectors with Natural Origin.

Adv Pharmacol Sci 2018 28;2018:5341487. Epub 2018 Nov 28.

Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, Av. Cel. Antonio Luiz, 1161, CEP 63105-000, Pimenta, Crato, Ceará, Brazil.

Many pathological problems are initiated by ultraviolet radiation (UVR), such as skin cancer, the most commonly diagnosed cancer worldwide. The UVA (320-400 nm) and UVB (290-320 nm) wavelengths may cause effects such as photoaging, DNA damage, and a series of cellular alterations. The UVA radiation can damage the DNA, oxidize the lipids, and produce dangerous free radicals, which can cause inflammation, modify the gene expression in response to stress, and weaken the skin immune response. Read More

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https://www.hindawi.com/journals/aps/2018/5341487/
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http://dx.doi.org/10.1155/2018/5341487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304211PMC
November 2018
18 Reads

Comparison of Antimicrobial Activity of Cloves from China and Taşköprü, Turkey.

Adv Pharmacol Sci 2018 27;2018:9302840. Epub 2018 Nov 27.

Kastamonu University, Department of Biology, Faculty of Science and Arts, Kastamonu, Turkey.

In this study, antimicrobial activities of two different samples of L. from Turkey (TR) (Taşköprü, Kastamonu, Turkey) and China (CN) were determined. A broad spectrum of Gram-negative and Gram-positive bacteria (17 bacteria) including species of , , , , , , , , and were used for testing antibacterial activity. Read More

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http://dx.doi.org/10.1155/2018/9302840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288568PMC
November 2018
2 Reads

Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders.

Adv Pharmacol Sci 2018 27;2018:3632159. Epub 2018 Nov 27.

Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Lucknow 226028, UP, India.

Neuronal developmental disorder is a class of diseases in which there is impairment of the central nervous system and brain function. The brain in its developmental phase undergoes tremendous changes depending upon the stage and environmental factors. Neurodevelopmental disorders include abnormalities associated with cognitive, speech, reading, writing, linguistic, communication, and growth disorders with lifetime effects. Read More

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http://dx.doi.org/10.1155/2018/3632159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288580PMC
November 2018
7 Reads

HPTLC Analysis of Schrad. and Wendl., a Medicinal Herb.

Adv Pharmacol Sci 2018 8;2018:8546306. Epub 2018 Nov 8.

Department of Botany, Punjabi University, Patiala, Punjab, India.

In the present study, HPTLC is used to detect the presence and amount of triterpenoids and phytosterols in different plant parts (fruit, stem, leaf, and root) of Schrad. and Wendl.; such analysis is done for the first time. Read More

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http://dx.doi.org/10.1155/2018/8546306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250026PMC
November 2018
3 Reads

Antidiabetic Effects of the Ethanolic Root Extract of P. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus.

Adv Pharmacol Sci 2018 8;2018:1314941. Epub 2018 Nov 8.

Department of Pharmacology and Therapeutics, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.

Diabetes mellitus has been a menace to mankind from time immemorial. However, a natural product such as P. Beauv (Annonaceae) offers alternative treatment for diabetes mellitus. Read More

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http://dx.doi.org/10.1155/2018/1314941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250042PMC
November 2018
1 Read

Investigation of Antioxidant/Oxidant Status and Antimicrobial Activities of .

Authors:
Mustafa Sevindik

Adv Pharmacol Sci 2018 1;2018:1718025. Epub 2018 Nov 1.

Department of Biology, Faculty of Science, Akdeniz University, Antalya, Turkey.

In the present study, antioxidant and antimicrobial potential of the (Bull.) Fr. mushroom was determined. Read More

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https://www.hindawi.com/journals/aps/2018/1718025/
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http://dx.doi.org/10.1155/2018/1718025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236708PMC
November 2018
14 Reads

Simultaneous Determination of Phenolic Compounds in (Forssk.) Decne. by Using High-Performance Liquid Chromatography (HPLC-DAD-UV).

Adv Pharmacol Sci 2018 21;2018:9604972. Epub 2018 Oct 21.

Department of Botany, Punjabi University, Patiala 147002, Punjab, India.

During the present study, an endeavor has been made to produce a simple, rapid, and simultaneous method for determination of phenolic compounds by using high-performance liquid chromatography in aerial parts of (Forssk.) Decne. collected from the Indian Thar Desert. Read More

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http://dx.doi.org/10.1155/2018/9604972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215595PMC
October 2018
1 Read

Crude Polysaccharides from Okra Pods () Grown in Indonesia Enhance the Immune Response due to Bacterial Infection.

Adv Pharmacol Sci 2018 9;2018:8505383. Epub 2018 Oct 9.

Department of Biology, Faculty of Science and Technology, Airlangga University, Surabaya 60115, Indonesia.

Okra pods were widely consumed by Indonesians to maintain health. The aim of this study was at investigating the potential of crude polysaccharides from okra pods on immune response in mice infected with Thirty male Balb/C mice were divided into six groups: normal control, negative control, and treatment groups (administration of crude polysaccharides at doses of 25, 50, 75, and 100 mg/kg). Crude polysaccharides were administrated for fourteen days. Read More

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https://www.hindawi.com/journals/aps/2018/8505383/
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http://dx.doi.org/10.1155/2018/8505383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198543PMC
October 2018
10 Reads

Updates on the Status of Vitamin D as a Risk Factor for Respiratory Distress Syndrome.

Adv Pharmacol Sci 2018 30;2018:8494816. Epub 2018 Sep 30.

Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

To update the guidelines regarding vitamin D status in respiratory distress syndrome, we reviewed recent human and animal studies on the benefits of vitamin D in respiratory distress. We searched PubMed and ProQuest for studies on the use of vitamin D from 2009 to 2017. The common parameters in these studies included the use of lung tissue, phospholipids, blood, and plasma to assess the effects of vitamin D on respiratory syndrome. Read More

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https://www.hindawi.com/journals/aps/2018/8494816/
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http://dx.doi.org/10.1155/2018/8494816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186338PMC
September 2018
25 Reads

Cytotoxicity of the Aqueous Extract and Organic Fractions from on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29.

Adv Pharmacol Sci 2018 23;2018:3297193. Epub 2018 Aug 23.

Laboratory of Physiology, Genetic and Ethnopharmacology, Faculty of Sciences, Mohammed the First University, PB 717, 60000 Oujda, Morocco.

The toxicity of the aqueous extract of was tested (5 and 10 g/kg) in albino mice. No symptoms of toxicity or mortality were observed. The mice survived being active and healthy during all 14 days of observation. Read More

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https://www.hindawi.com/journals/aps/2018/3297193/
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http://dx.doi.org/10.1155/2018/3297193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126111PMC
August 2018
7 Reads

A Review of Malaysian Medicinal Plants with Potential Anti-Inflammatory Activity.

Adv Pharmacol Sci 2018 9;2018:8603602. Epub 2018 Jul 9.

Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia (UTHM), Hab Pendidikan Tinggi Pagoh, KM 1, Jalan Panchor, 84600 Muar, Johor, Malaysia.

This article aims to provide detailed information on Malaysian plants used for treating inflammation. An extensive search on electronic databases including PubMed, Google Scholar, Scopus, and ScienceDirect and conference papers was done to find relevant articles on anti-inflammatory activity of Malaysian medicinal plants. The keyword search terms used were "inflammation," "Malaysia," "medicinal plants," "mechanisms," "," and ". Read More

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http://dx.doi.org/10.1155/2018/8603602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079619PMC
July 2018
15 Reads

Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs.

Adv Pharmacol Sci 2018 24;2018:4848602. Epub 2018 Jun 24.

Department of Veterinary Preclinical Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.

Doxorubicin (DOX) is a potent anticancer agent with cytotoxic effects which limit its clinical usage. This effect is due to its nonselective nature causing injury to the cells as a result of reactive free oxygen radical's release. Cockleshell-derived calcium carbonate nanoparticle (CS-CaCONP) is a pH-responsive carrier with targeted delivery potentials. Read More

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http://dx.doi.org/10.1155/2018/4848602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035816PMC
June 2018
4 Reads

Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films.

Adv Pharmacol Sci 2018 25;2018:8043837. Epub 2018 Jun 25.

Department of Biology, Temple University, 1900 N. 12th Street, Philadelphia, PA 19122, USA.

Bitter taste is aversive to humans, and many oral medications exhibit a bitter taste. Bitter taste can be suppressed by the use of inhibitors or by masking agents such as sucralose. Another approach is to encapsulate bitter tasting compounds in order to delay their release. Read More

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http://dx.doi.org/10.1155/2018/8043837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036852PMC
June 2018
4 Reads

Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease's Statin Therapy in Men.

Adv Pharmacol Sci 2018 17;2018:4673061. Epub 2018 May 17.

Department of Physiology, Faculty of Natural Sciences and Mathematics, "Ss. Cyril and Methodius" University, Skopje, Macedonia.

Oxidative stress and inflammation contribute to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD), and the control of lipid status by statins may help to stop the progression of NAFLD. We hypothesized that the addition of antioxidant vitamins C and E to atorvastatin therapy is associated with improved serum enzyme antioxidant status. NAFLD-related serum parameters and the activity of antioxidant enzymes, before and after 3 months of treatment, were determined in patients receiving atorvastatin alone or atorvastatin plus antioxidants. Read More

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http://dx.doi.org/10.1155/2018/4673061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985129PMC
May 2018
5 Reads

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities.

Adv Pharmacol Sci 2018 2;2018:9794625. Epub 2018 May 2.

Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde 51240, Turkey.

Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as . This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. Read More

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http://dx.doi.org/10.1155/2018/9794625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954929PMC
May 2018
20 Reads

Antibacterial Activity of Two Flavans from the Stem Bark of .

Adv Pharmacol Sci 2018 30;2018:5870161. Epub 2018 Apr 30.

Applied Chemistry Program, School of Applied Natural Science, Adama Science and Technology University, P.O. Box 1888, Adama, Ethiopia.

Vatke is one of the medicinal plants used traditionally for treatment of intestinal tape worm, dysmenorrheal, bacterial, and fungal infections. Phytochemical screening test of the dichloromethane/methanol (1 : 1) and methanol extracts revealed the presence of phenols, alkaloids, tannins, and flavonoids whereas terpenoids, glycoside, and phytosterols were absent. Silica gel column chromatographic separation of the methanol extract afforded 3,5,7,3',4'-pentahydroxyflavan, named epicatechin (), along with a close flavan derivative (). Read More

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https://www.hindawi.com/journals/aps/2018/5870161/
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http://dx.doi.org/10.1155/2018/5870161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952501PMC
April 2018
21 Reads

Efficacy of , , and Cream on the Skin Wound Infected with MRSA.

Adv Pharmacol Sci 2018 19;2018:4670569. Epub 2018 Apr 19.

Faculty of Veterinary Medicine, University of Wijaya Kusuma Surabaya, East Java, Indonesia.

The tropical area has a lot of herbal medicines such as (AV), (AC), and (SM). All the three have a unique potential effect as an antibacterial and wound-healing promoter. The aim of this study is to explore the role of AV, AC, and SM on the skin wound infected with methicillin-resistant (MRSA). Read More

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http://dx.doi.org/10.1155/2018/4670569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933069PMC
April 2018
6 Reads

Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One.

Adv Pharmacol Sci 2018 1;2018:6042602. Epub 2018 Apr 1.

PharmacodynamyResearch Team PRT, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, BP 6203, Rabat, Morocco.

The objective of our work is to make a pharmacological study of molecules derived from 4-phenyl-1,5-benzodiazepin-2-one carrying long chains so that they have a structure similar to surfactants, with the benzodiazepine as a hydrophilic head and a carbon chain as a hydrophobic tail. First, we studied the acute toxicity of the above mentioned 4-phenyl-1,5-benzodiazepin-2-one derivatives. This study was conducted according to OECD 423 guidelines in female mice and revealed that these compounds are nontoxic. Read More

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http://dx.doi.org/10.1155/2018/6042602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902104PMC
April 2018
24 Reads

Studies on the Dual Cytotoxicity and Antioxidant Properties of Extracts and Its Main Constituent Berberine.

Adv Pharmacol Sci 2018 8;2018:3018498. Epub 2018 Jan 8.

Laboratory of Biological Engineering, Natural Substances, Cellular and Molecular Immuno-Pharmacology Team, Immunobiology of Cancer Cells, Faculty of Sciences and Technology of Beni Mellal, P.O. Box 523, 23000 Beni-Mellal, Morocco.

The present study attempts to investigate the cytotoxic activity of ethanol and ethyl acetate extracts of the Moroccan and its major component berberine, together with exploring their antioxidant properties. It also consists of studying the combination effect of berberine and S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO) donor, against the human breast adenocarcinoma cell line (MCF-7). Using the MTT assay, we report a differential cytotoxic effect of ethanol and ethyl acetate extracts since the ethanol extract is more cytotoxic than the ethyl acetate one, with IC = 3. Read More

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http://dx.doi.org/10.1155/2018/3018498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817274PMC
January 2018
33 Reads

Antibacterial and Antioxidant Compounds from the Flower Extracts of .

Adv Pharmacol Sci 2018 20;2018:4083736. Epub 2018 Mar 20.

Chemistry Department, Applied Natural Sciences, Adama Science and Technology University, Adama, Ethiopia.

is traditionally used in Ethiopia to treat various diseases. This prompted us to isolate bioactive compounds from the flowers of this plant. The CHCl extract after silica gel column chromatography has led to the isolation of two compounds identified as tricosane and vernolide , while the acetone extract furnished isorhamnetin and luteolin . Read More

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http://dx.doi.org/10.1155/2018/4083736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884303PMC
March 2018
4 Reads

Downregulation of Thromboxane A Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery.

Adv Pharmacol Sci 2017 9;2017:6507048. Epub 2017 Jul 9.

Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.

Thromboxane A (TXA) acts on TXA receptors (TP) to regulate renal artery blood flow and subsequently contributes to the pathogenesis of renal ischemia. The present study was designed to examine if nuclear factor-kappaB (NF-B) signaling pathway is involved in the downregulation of TP receptors in rat renal artery. Rat renal artery segments were organ cultured for 6 or 24 h. Read More

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http://dx.doi.org/10.1155/2017/6507048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523459PMC
July 2017
24 Reads

Chemical Composition and Cytotoxic and Antibacterial Activities of the Essential Oil of Palau Grown in Morocco.

Adv Pharmacol Sci 2017 12;2017:7801924. Epub 2017 Jun 12.

Laboratory of Biological Engineering, Natural Substances, Cellular and Molecular Immuno-Pharmacology, Immunobiology of Cancer Cells Cluster, Faculty of Science and Technology, Sultan Moulay Slimane University, Beni Mellal, Morocco.

The aim of this work is to investigate the cytotoxic and antibacterial effects of the essential oils of Palau, harvested in different regions of Morocco. The chemical profile was established using gas chromatography-mass spectrometry analysis. The cytotoxic activity against P815, MCF7, and VERO cell lines as well as the normal human peripheral blood mononuclear cells (PBMCs) was evaluated using the MTT assay. Read More

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http://dx.doi.org/10.1155/2017/7801924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485486PMC
June 2017
46 Reads

The Effects of Flower Extract on Skin Injuries Induced by Burn in Rats.

Adv Pharmacol Sci 2017 19;2017:3059745. Epub 2017 Jan 19.

Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.

. We compared the efficacy of (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. . Read More

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http://dx.doi.org/10.1155/2017/3059745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288512PMC
January 2017
20 Reads

Neuroprotection in Glaucoma: Old and New Promising Treatments.

Adv Pharmacol Sci 2017 17;2017:4320408. Epub 2017 Oct 17.

Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, Rome, Italy.

Glaucoma is a major global cause of blindness, but the molecular mechanisms responsible for the neurodegenerative damage are not clear. Undoubtedly, the high intraocular pressure (IOP) and the secondary ischemic and mechanical damage of the optic nerve have a crucial role in retinal ganglion cell (RGC) death. Several studies specifically analyzed the events that lead to nerve fiber layer thinning, showing the importance of both intra- and extracellular factors. Read More

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http://dx.doi.org/10.1155/2017/4320408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664381PMC
October 2017
4 Reads

Phytochemical and Pharmacological Review of (Lindl.) Schlechter.

Adv Pharmacol Sci 2017 15;2017:3026370. Epub 2017 Oct 15.

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Ethnopharmacological Relevance: is a scrambling thin-stemmed shrub found in Africa. Traditionally in West Africa, it is employed in the treatment of malaria, diarrhea, and respiratory conditions. This review discusses the traditional importance as well as the phytochemical, ethnomedical, pharmacological, and toxicological importance of this plant. Read More

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http://dx.doi.org/10.1155/2017/3026370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661077PMC
October 2017
4 Reads

Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats.

Adv Pharmacol Sci 2016 20;2016:3094783. Epub 2016 Nov 20.

Department of Pharmacology, University of the Free State, P.O. Box 339, Bloemfontein 9300, South Africa.

The aim of this study was to illustrate the initial subclinical drug-induced liver injury and the associated adaptive immune response by monitoring for the changes in plasma IL-2, IL-10, and some cytochrome P450 activity during chronic administration of nevirapine (NVP), isoniazid (INH), and paracetamol (PAR) in rats without clinical hepatotoxicity. Male Sprague-Dawley (SD) rats were divided into four groups (saline (S), NVP, INH, and PAR) of 25 animals each. The drugs were administered daily for 42 days at therapeutic doses (NVP 200 mg/kg, PAR 500 mg/kg, and INH 20 mg/kg) to the respective groups by oral gavage and five rats per group were sacrificed weekly. Read More

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http://dx.doi.org/10.1155/2016/3094783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136381PMC
November 2016
14 Reads

The Methanolic Extract from L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K Channel as Antinociceptive Mechanism.

Adv Pharmacol Sci 2016 12;2016:3790860. Epub 2016 Oct 12.

Department of Pharmacy, Stamford University Bangladesh, 51 Shiddheswari Road, Dhaka 1217, Bangladesh.

L. is a perennial shrub, belonging to the family Rutaceae. Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation. Read More

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http://dx.doi.org/10.1155/2016/3790860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080466PMC
October 2016
16 Reads

Thrombus Degradation by Fibrinolytic Enzyme of Stenotrophomonas sp. Originated from Indonesian Soybean-Based Fermented Food on Wistar Rats.

Adv Pharmacol Sci 2016 21;2016:4206908. Epub 2016 Aug 21.

Faculty of Biotechnology, Atmajaya University, Jalan Jenderal Sudirman 51, Jakarta Selatan 12930, Indonesia; Department of Food Science and Technology, Faculty of Agricultural Engineering and Technology, Bogor Agricultural University, Bogor 16002, Indonesia.

Objective. To evaluate thrombus degrading effect of a fibrinolytic enzyme from food origin Stenotrophomonas sp. of Indonesia. Read More

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http://dx.doi.org/10.1155/2016/4206908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011239PMC
September 2016
16 Reads