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    158 results match your criteria Advances in Pharmacological Sciences [Journal]

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    Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery.
    Adv Pharmacol Sci 2017 9;2017:6507048. Epub 2017 Jul 9.
    Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
    Thromboxane A2 (TXA2) acts on TXA2 receptors (TP) to regulate renal artery blood flow and subsequently contributes to the pathogenesis of renal ischemia. The present study was designed to examine if nuclear factor-kappaB (NF-κB) signaling pathway is involved in the downregulation of TP receptors in rat renal artery. Rat renal artery segments were organ cultured for 6 or 24 h. Read More

    Chemical Composition and Cytotoxic and Antibacterial Activities of the Essential Oil of Aloysia citriodora Palau Grown in Morocco.
    Adv Pharmacol Sci 2017 12;2017:7801924. Epub 2017 Jun 12.
    Laboratory of Biological Engineering, Natural Substances, Cellular and Molecular Immuno-Pharmacology, Immunobiology of Cancer Cells Cluster, Faculty of Science and Technology, Sultan Moulay Slimane University, Beni Mellal, Morocco.
    The aim of this work is to investigate the in vitro cytotoxic and antibacterial effects of the essential oils of Aloysia citriodora Palau, harvested in different regions of Morocco. The chemical profile was established using gas chromatography-mass spectrometry analysis. The cytotoxic activity against P815, MCF7, and VERO cell lines as well as the normal human peripheral blood mononuclear cells (PBMCs) was evaluated using the MTT assay. Read More

    The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats.
    Adv Pharmacol Sci 2017 19;2017:3059745. Epub 2017 Jan 19.
    Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
    Background. We compared the efficacy of P. granatum (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. Read More

    Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats.
    Adv Pharmacol Sci 2016 20;2016:3094783. Epub 2016 Nov 20.
    Department of Pharmacology, University of the Free State, P.O. Box 339, Bloemfontein 9300, South Africa.
    The aim of this study was to illustrate the initial subclinical drug-induced liver injury and the associated adaptive immune response by monitoring for the changes in plasma IL-2, IL-10, and some cytochrome P450 activity during chronic administration of nevirapine (NVP), isoniazid (INH), and paracetamol (PAR) in rats without clinical hepatotoxicity. Male Sprague-Dawley (SD) rats were divided into four groups (saline (S), NVP, INH, and PAR) of 25 animals each. The drugs were administered daily for 42 days at therapeutic doses (NVP 200 mg/kg, PAR 500 mg/kg, and INH 20 mg/kg) to the respective groups by oral gavage and five rats per group were sacrificed weekly. Read More

    The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism.
    Adv Pharmacol Sci 2016 12;2016:3790860. Epub 2016 Oct 12.
    Department of Pharmacy, Stamford University Bangladesh, 51 Shiddheswari Road, Dhaka 1217, Bangladesh.
    Murraya koenigii L. is a perennial shrub, belonging to the family Rutaceae. Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation. Read More

    Thrombus Degradation by Fibrinolytic Enzyme of Stenotrophomonas sp. Originated from Indonesian Soybean-Based Fermented Food on Wistar Rats.
    Adv Pharmacol Sci 2016 21;2016:4206908. Epub 2016 Aug 21.
    Faculty of Biotechnology, Atmajaya University, Jalan Jenderal Sudirman 51, Jakarta Selatan 12930, Indonesia; Department of Food Science and Technology, Faculty of Agricultural Engineering and Technology, Bogor Agricultural University, Bogor 16002, Indonesia.
    Objective. To evaluate thrombus degrading effect of a fibrinolytic enzyme from food origin Stenotrophomonas sp. of Indonesia. Read More

    Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties.
    Adv Pharmacol Sci 2016 11;2016:3040724. Epub 2016 Jul 11.
    Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
    Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. Read More

    MDMA Impairs Response to Water Intake in Healthy Volunteers.
    Adv Pharmacol Sci 2016 14;2016:2175896. Epub 2016 Jun 14.
    Addiction and Pharmacology Research Laboratory, Friends Research Institute, Baltimore, MD 21201, USA.
    Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In Study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic inverse agonist prazosin, used as a positive control to release antidiuretic hormone (ADH). Read More

    A Review on Medicinal Properties of Orientin.
    Adv Pharmacol Sci 2016 19;2016:4104595. Epub 2016 May 19.
    Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, 31900 Kampar, Perak, Malaysia.
    Medicinal plants continue to play an important role in modern medications and healthcare as consumers generally believe that most of them cause fewer or milder adverse effects than the conventional modern medicines. In order to use the plants as a source of medicinal agents, the bioactive compounds are usually extracted from plants. Therefore, the extraction of bioactive compounds from medicinal plants is a crucial step in producing plant-derived drugs. Read More

    Radical-Scavenging Activity and Ferric Reducing Ability of Juniperus thurifera (L.), J. oxycedrus (L.), J. phoenicea (L.) and Tetraclinis articulata (L.).
    Adv Pharmacol Sci 2016 16;2016:6392656. Epub 2016 May 16.
    Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, BP 6203, Rabat-Instituts, Rabat, Morocco.
    Objective. The aim of this work is to study and compare the antioxidant properties and phenolic contents of aqueous leaf extracts of Juniperus thurifera, Juniperus oxycedrus, Juniperus Phoenicea, and Tetraclinis articulata from Morocco. Methods. Read More

    Review of Anti-Inflammatory Herbal Medicines.
    Adv Pharmacol Sci 2016 10;2016:9130979. Epub 2016 May 10.
    School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
    Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies. Read More

    Cytotoxicity and Antiproliferative Activity Assay of Clove Mistletoe (Dendrophthoe pentandra (L.) Miq.) Leaves Extracts.
    Adv Pharmacol Sci 2016 23;2016:3242698. Epub 2016 Mar 23.
    Department of Veterinary Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor 16680, Indonesia.
    Clove mistletoe (Dendrophthoe pentandra (L.) Miq.) is a semiparasitic plant that belongs to Loranthaceae family. Read More

    The Influence of Palatable Diets in Reward System Activation: A Mini Review.
    Adv Pharmacol Sci 2016 20;2016:7238679. Epub 2016 Mar 20.
    Pharmacology of Pain and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil; Graduate Program in Biological Sciences-Physiology, Universidade Federal do Rio Grande do Sul, Institute of Basic Health Sciences, 90050-170 Porto Alegre, RS, Brazil.
    The changes in eating patterns that have occurred in recent decades are an important cause of obesity. Food intake and energy expenditure are controlled by a complex neural system involving the hypothalamic centers and peripheral satiety system (gastrointestinal and pancreatic hormones). Highly palatable and caloric food disrupts appetite regulation; however, palatable foods induce pleasure and reward. Read More

    Pharmacokinetics of Immediate and Sustained Release Cephalexin Administered by Different Routes to Llamas (Lama glama).
    Adv Pharmacol Sci 2016 9;2016:4621039. Epub 2016 Mar 9.
    Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Chorroarín 280, 1427 Ciudad Autónoma de Buenos Aires, Argentina.
    We investigate the pharmacokinetics of two different cephalexin formulations administered to llamas by the intravenous (IV), intramuscular (IM), and subcutaneous (SC) routes, the minimum inhibitory concentration (MIC) of cephalexin against some Escherichia coli and staphylococci isolated from llamas, and we apply the PK/PD modelling approach, so that effective dosage recommendations for this species could be made. Six llamas received immediate (10 mg/kg, IV, IM, and SC) and sustained (8 mg/kg IM, SC) release cephalexin. Pharmacokinetic parameters were calculated by noncompartmental approach. Read More

    Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study.
    Adv Pharmacol Sci 2016 6;2016:4608979. Epub 2016 Mar 6.
    Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.
    The present study was designed to investigate the role of combined administration of Ramipril and Candesartan against in vitro myocardial ischemic reperfusion injury in rat. Male Wistar albino rats were divided into five groups (n = 6) and treated with saline (10 mL/kg), Ramipril (2 mg/kg), Candesartan (1 mg/kg), and the combination of both drugs, respectively 24 h before induction of global ischemia (5 min of stabilization, 9 min of global ischemia, and 12 min of reflow). Combination of Ramipril and Candesartan when compared to the monotherapy significantly increased the levels of superoxide dismutase, reduced glutathione, catalase, and nitric oxide and decreased the levels of thiobarbituric acid reactive substances. Read More

    Gender Difference in Renal Blood Flow Response to Angiotensin II Administration after Ischemia/Reperfusion in Rats: The Role of AT2 Receptor.
    Adv Pharmacol Sci 2016 10;2016:7294942. Epub 2016 Mar 10.
    Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran; Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745, Iran; Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan 81546, Iran.
    Background. Renal ischemia/reperfusion (I/R) is one of the major causes of kidney failure, and it may interact with renin angiotensin system while angiotensin II (Ang II) type 2 receptor (AT2R) expression is gender dependent. We examined the role of AT2R blockade on vascular response to Ang II after I/R in rats. Read More

    Cytotoxic Activity of Holothuria leucospilota Extract against Leishmania infantum In Vitro.
    Adv Pharmacol Sci 2016 28;2016:8195381. Epub 2016 Feb 28.
    Department of Medical Parasitology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Leishmaniasis is a tropical parasitic infection. The resistance and toxicity issues are the major complications and remain significant consequences related to the treatment of leishmaniasis with the recent and classical drugs. Thus there is an immediate requirement to develop new compounds for the treatment of this protozoan disease. Read More

    Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015.
    Adv Pharmacol Sci 2016 21;2016:3046373. Epub 2016 Feb 21.
    Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
    Major β-thalassemia (β-TM) is one of the most common inherited hemolytic types of anemia which is caused as a result of absent or reduced synthesis of β-globin chains of hemoglobin. This defect results in red blood cells lysis and chronic anemia that can be treated by multiple blood transfusions and iron chelation therapy. Without iron chelation therapy, iron overload will cause lots of complications in patients. Read More

    Drug Efflux Transporters Are Overexpressed in Short-Term Tamoxifen-Induced MCF7 Breast Cancer Cells.
    Adv Pharmacol Sci 2016 14;2016:6702424. Epub 2016 Feb 14.
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia.
    Tamoxifen is the first line drug used in the treatment of estrogen receptor-positive (ER+) breast cancer. The development of multidrug resistance (MDR) to tamoxifen remains a major challenge in the treatment of cancer. One of the mechanisms related to MDR is decrease of drug influx via overexpression of drug efflux transporters such as P-glycoprotein (P-gp/MDR1), multidrug resistance associated protein (MRP), or BCRP (breast cancer resistance protein). Read More

    Involvement of Inflammatory Cytokines in Antiarrhythmic Effects of Clofibrate in Ouabain-Induced Arrhythmia in Isolated Rat Atria.
    Adv Pharmacol Sci 2016 10;2016:9128018. Epub 2016 Feb 10.
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Considering the cardioprotective and anti-inflammatory properties of clofibrate, the aim of the present experiment was to investigate the involvement of local and systemic inflammatory cytokines in possible antiarrhythmic effects of clofibrate in ouabain-induced arrhythmia in rats. Rats were orally treated with clofibrate (300 mg/kg), and ouabain (0.56 mg/kg) was administered to animals intraperitoneally. Read More

    A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease.
    Adv Pharmacol Sci 2016 28;2016:8964849. Epub 2016 Jan 28.
    Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
    The current management of Alzheimer's disease (AD) focuses on acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, although outcomes are not completely favorable. Hence, novel agents found in herbal plants are gaining attention as possible therapeutic alternatives. The Terminalia chebula (Family: Combretaceae) is a medicinal plant with a wide spectrum of medicinal properties and is reported to contain various biochemicals such as hydrolysable tannins, phenolic compounds, and flavonoids, so it may prove to be a good therapeutic alternative. Read More

    Protective Effect of Diospyros kaki against Glucose-Oxygen-Serum Deprivation-Induced PC12 Cells Injury.
    Adv Pharmacol Sci 2016 28;2016:3073078. Epub 2016 Jan 28.
    Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran; Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran; Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
    Ischemic cerebrovascular disease is one of the most common causes of death in the world. Recent interests have been focused on natural antioxidants and anti-inflammatory agents as potentially useful neuroprotective agents. Diospyros kaki (persimmon) has been shown to exert anti-inflammatory, antioxidant, and antineoplastic effects. Read More

    Methanolic Extract of Ceplukan Leaf (Physalis minima L.) Attenuates Ventricular Fibrosis through Inhibition of TNF-α in Ovariectomized Rats.
    Adv Pharmacol Sci 2016 31;2016:2428052. Epub 2016 Jan 31.
    Department of Cardiology and Vascular Medicine, Medical Faculty, Brawijaya University, Saiful Anwar General Hospital, Malang 65145, Indonesia.
    The increase of heart failure prevalence on menopausal women was correlated with the decrease of estrogen level. The aim of this study is to investigate the effects of ceplukan leaf (Physalis minima L.), which contains phytoestrogen physalin and withanolides, on ventricular TNF-α level and fibrosis in ovariectomized rats. Read More

    In Vitro Study on Glucose Utilization Capacity of Bioactive Fractions of Houttuynia cordata in Isolated Rat Hemidiaphragm and Its Major Phytoconstituent.
    Adv Pharmacol Sci 2016 26;2016:2573604. Epub 2016 Jan 26.
    Pharmacognosy Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India.
    Objective. The whole plant of Houttuynia cordata has been reported to have potent antihyperglycemic activity. Therefore, the present study was undertaken to investigate the glucose utilization capacity of bioactive fractions of ethanol extract of Houttuynia cordata (HC) in isolated rat hemidiaphragm. Read More

    Effects of Curcumin on Parameters of Myocardial Oxidative Stress and of Mitochondrial Glutathione Turnover in Reoxygenation after 60 Minutes of Hypoxia in Isolated Perfused Working Guinea Pig Hearts.
    Adv Pharmacol Sci 2016 21;2016:6173648. Epub 2016 Jan 21.
    Medical Research Unit, Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia.
    In cardiovascular surgery ischemia-reperfusion injury is a challenging problem, which needs medical intervention. We investigated the effects of curcumin on cardiac, myocardial, and mitochondrial parameters in perfused isolated working Guinea pig hearts. After preliminary experiments to establish the model, normoxia was set at 30 minutes, hypoxia was set at 60, and subsequent reoxygenation was set at 30 minutes. Read More

    Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves.
    Adv Pharmacol Sci 2016 17;2016:9436106. Epub 2016 Jan 17.
    Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382 481, India.
    In the present study, we evaluated anti-Parkinson's activity of petroleum ether extract of Ficus religiosa (PEFRE) leaves in haloperidol and 6 hydroxydopamine (6-OHDA) induced experimental animal models. In this study, effects of Ficus religiosa (100, 200, and 400 mg/kg, p.o. Read More

    Integrating TRPV1 Receptor Function with Capsaicin Psychophysics.
    Adv Pharmacol Sci 2016 14;2016:1512457. Epub 2016 Jan 14.
    Department of Biology, Temple University, 1900 N. 12th Street, Philadelphia, PA 19122, USA.
    Capsaicin is a naturally occurring vanilloid that causes a hot, pungent sensation in the human oral cavity. This trigeminal stimulus activates TRPV1 receptors and stimulates an influx of cations into sensory cells. TRPV1 receptors function as homotetramers that also respond to heat, proinflammatory substances, lipoxygenase products, resiniferatoxin, endocannabinoids, protons, and peptide toxins. Read More

    Development of an Experimental Model of Diabetes Co-Existing with Metabolic Syndrome in Rats.
    Adv Pharmacol Sci 2016 6;2016:9463476. Epub 2016 Jan 6.
    Department of Pharmacology, MGM Medical College, Kamothe, Navi Mumbai 410209, India.
    Background. The incidence of metabolic syndrome co-existing with diabetes mellitus is on the rise globally. Objective. Read More

    Crude Aloe vera Gel Shows Antioxidant Propensities and Inhibits Pancreatic Lipase and Glucose Movement In Vitro.
    Adv Pharmacol Sci 2016 3;2016:3720850. Epub 2016 Jan 3.
    Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius.
    Aloe vera gel (AVG) is traditionally used in the management of diabetes, obesity, and infectious diseases. The present study aimed to investigate the inhibitory potential of AVG against α-amylase, α-glucosidase, and pancreatic lipase activity in vitro. Enzyme kinetic studies using Michaelis-Menten (K m ) and Lineweaver-Burk equations were used to establish the type of inhibition. Read More

    Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey.
    Adv Pharmacol Sci 2015 20;2015:410675. Epub 2015 Dec 20.
    Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius.
    We aimed to investigate the inhibitory potential of three medicinal plants (Hedysarum varium, Onobrychis hypargyrea, and Vicia truncatula) from Turkey against key enzymes involved in human pathologies, namely, diabetes (α-amylase and α-glucosidase), neurodegenerative disorders (tyrosinase, acetylcholinesterase, and butyrylcholinesterase), and hyperpigmentation (tyrosinase). The antioxidant potential, phenolic and flavonoid content of ethyl acetate, and methanolic and aqueous extracts were investigated using in vitro assays. The total antioxidant capacity (TAC), β-carotene/linoleic acid bleaching activity, 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH(•)), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(•+)), cupric ion reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), and metal chelating activity on ferrous ions were used to evaluate the antioxidant capabilities of the extracts. Read More

    Olive Mill Waste Extracts: Polyphenols Content, Antioxidant, and Antimicrobial Activities.
    Adv Pharmacol Sci 2015 29;2015:714138. Epub 2015 Nov 29.
    Laboratory of Biological Engineering, Faculty of Science and Technologies, Sultan Moulay Slimane University, 23 000 Beni-Mellal, Morocco.
    Natural polyphenols extracts have been usually associated with great bioactive properties. In this work, we investigated in vitro antioxidant and antimicrobial potential of the phenolic olive mill wastewater extracts (OWWE) and the olive cake extracts (OCE). Using the Folin Ciocalteux method, OWWE contained higher total phenol content compared to OCE (8. Read More

    Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats?
    Adv Pharmacol Sci 2015 25;2015:298792. Epub 2015 Nov 25.
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Zagazig, Zagazig 44519, Egypt.
    The aims of the present work were to study the effects of chronic NO inhibition on liver cirrhosis and to analyze its relationship with liver and kidney damage markers. Two inhibitors of NO synthesis (inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG), and nonselective NOS inhibitor, L-nitroarginine methyl ester (L-NAME)) were administered for 6 weeks to bile duct ligated (BDL) rats 3 days after surgery. The present study showed that BDL was associated with liver injury and renal impairment. Read More

    High-Dose Estradiol-Replacement Therapy Enhances the Renal Vascular Response to Angiotensin II via an AT2-Receptor Dependent Mechanism.
    Adv Pharmacol Sci 2015 23;2015:682745. Epub 2015 Nov 23.
    Department of Physiology, Monash University, Clayton, VIC, Australia.
    Physiological levels of estrogen appear to enhance angiotensin type 2 receptor- (AT2R-) mediated vasodilatation. However, the effects of supraphysiological levels of estrogen, analogous to those achieved with high-dose estrogen replacement therapy in postmenopausal women, remain unknown. Therefore, we pretreated ovariectomized rats with a relatively high dose of estrogen (0. Read More

    Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study.
    Adv Pharmacol Sci 2015 22;2015:164943. Epub 2015 Nov 22.
    School of Biomedical Science, University of Newcastle, Newcastle, NSW 2308, Australia.
    The present study was designed to evaluate the acute and chronic antidepressant effect of genistein in combination with amitriptyline in mice. Animals were divided into six groups (n = 6) for treatment with water, genistein, or amitriptyline, either alone or in combination for ten days. Animals were subjected to locomotor activity testing; tail suspension test (TST); and forced swim test (FST) and immobility time was recorded on day one and day ten. Read More

    Targeting AGEs Signaling Ameliorates Central Nervous System Diabetic Complications in Rats.
    Adv Pharmacol Sci 2015 29;2015:346259. Epub 2015 Sep 29.
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt ; Department of Pharmacology, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.
    Diabetes is a chronic endocrine disorder associated with several complications as hypertension, advanced brain aging, and cognitive decline. Accumulation of advanced glycation end products (AGEs) is an important mechanism that mediates diabetic complications. Upon binding to their receptor (RAGE), AGEs mediate oxidative stress and/or cause cross-linking with proteins in blood vessels and brain tissues. Read More

    Therapeutic Potential of Dietary Phenolic Acids.
    Adv Pharmacol Sci 2015 9;2015:823539. Epub 2015 Sep 9.
    Amity Institute of Biotechnology, Amity University Haryana, Gurgaon, Manesar 122413, India.
    Although modern lifestyle has eased the quality of human life, this lifestyle's related patterns have imparted negative effects on health to acquire multiple diseases. Many synthetic drugs are invented during the last millennium but most if not all of them possess several side effects and proved to be costly. Convincing evidences have established the premise that the phytotherapeutic potential of natural compounds and need of search for novel drugs from natural sources are of high priority. Read More

    Melatonin and Ischemic Stroke: Mechanistic Roles and Action.
    Adv Pharmacol Sci 2015 7;2015:384750. Epub 2015 Sep 7.
    Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India ; Department of Biochemistry, Jamia Hamdard (Hamdard University), New Delhi 110062, India.
    Stroke is one of the most devastating neurological disabilities and brain's vulnerability towards it proves to be fatal and socio-economic loss of millions of people worldwide. Ischemic stroke remains at the center stage of it, because of its prevalence amongst the several other types attacking the brain. The various cascades of events that have been associated with stroke involve oxidative stress, excitotoxicity, mitochondrial dysfunction, upregulation of Ca(2+) level, and so forth. Read More

    Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats.
    Adv Pharmacol Sci 2015 3;2015:801053. Epub 2015 Sep 3.
    Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Isfahan Institute of Basic & Applied Sciences Research, Isfahan 81546, Iran.
    Background. The accompanied role of Mas receptor (MasR), bradykinin (BK), and female sex hormone on renal blood flow (RBF) response to angiotensin 1-7 is not well defined. We investigated the role of MasR antagonist (A779) and BK on RBF response to Ang 1-7 infusion in ovariectomized estradiol-treated rats. Read More

    Validated HPTLC Method for Quantification of Luteolin and Apigenin in Premna mucronata Roxb., Verbenaceae.
    Adv Pharmacol Sci 2015 3;2015:682365. Epub 2015 Sep 3.
    Department of Pharmacology, Anand Pharmacy College, Shri Ram Krishna Seva Mandal Campus, Near Town Hall, Anand, Gujarat 388001, India.
    A simple, rapid, and precise high-performance thin-layer chromatographic method was developed for quantitative estimation of luteolin and apigenin in Premna mucronata Roxb., family Verbenaceae. Separation was performed on silica gel 60 F254 HPTLC plates using toluene : ethyl acetate : formic acid (6 : 4 : 0. Read More

    BF3·Et2O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization.
    Adv Pharmacol Sci 2015 1;2015:527159. Epub 2015 Sep 1.
    Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi 221005, India.
    We have synthesized the novel 4-(4-hydroxy-benzyl)-3-phenyl-chromen-2-one which is a precursor of SERMs with a smaller number of steps and good yield. Two methodologies for the synthesis have been worked out. Anhydrous BF3·Et2O catalyzed reaction was found to be selective for product formation while anhydrous AlCl3, FeCl3, and SnCl4 catalyzed ones were nonselective. Read More

    Antihyperglycemic Activity of Eucalyptus tereticornis in Insulin-Resistant Cells and a Nutritional Model of Diabetic Mice.
    Adv Pharmacol Sci 2015 20;2015:418673. Epub 2015 Aug 20.
    Molecular Genetics Group, University of Antioquia, Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia ; Department of Physiology and Biochemistry, School of Medicine, University of Antioquia, Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
    Eucalyptus tereticornis is a plant used in traditional medicine to control diabetes, but this effect has not been proved scientifically. Here, we demonstrated through in vitro assays that E. tereticornis extracts increase glucose uptake and inhibit their production in insulin-resistant C2C12 and HepG2 cells, respectively. Read More

    Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice.
    Adv Pharmacol Sci 2015 20;2015:132873. Epub 2015 Aug 20.
    Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
    Spirulina is a blue-green alga used as a dietary supplement. It has been shown to possess anti-inflammatory, antioxidant, and hepatoprotective properties. This study was designed to evaluate the antitumor effect of spirulina (200 and 800 mg/kg) against a murine model of solid Ehrlich carcinoma compared to a standard chemotherapeutic drug, 5-fluorouracil (20 mg/kg). Read More

    Evaluation of Antidiarrheal Activity of Methanolic Extract of Maranta arundinacea Linn. Leaves.
    Adv Pharmacol Sci 2015 6;2015:257057. Epub 2015 Aug 6.
    Department of Systems Biotechnology, Chung-Ang University, Anseong 456-756, Republic of Korea.
    Diarrhea is one of the most common causes for thousands of deaths every year. Therefore, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research. Our aim was to investigate the antidiarrheal and cytotoxic activities of methanolic extract of Maranta arundinacea linn. Read More

    Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats.
    Adv Pharmacol Sci 2015 2;2015:521718. Epub 2015 Aug 2.
    Department of Anatomy, Melaka Manipal Medical College, Manipal University, Manipal Campus, Manipal 576104, India.
    Lisinopril and fosinopril were compared on scopolamine-induced learning and memory deficits in rats. A total of eighty-four male Wistar rats were divided into seven groups. Group I received 2% gum acacia orally for 4 weeks, group II received normal saline, and group III received scopolamine (2 mg/kg/ip) as single dose. Read More

    Antileishmanial Effect of 5,3'-Hydroxy-7,4'-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies.
    Adv Pharmacol Sci 2015 30;2015:978379. Epub 2015 Apr 30.
    Chemistry of Colombian Plants, Institute of Chemistry, Exact and Natural Sciences School, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
    Species of Picramnia genus are used in folk medicine to treat or prevent skin disorders, but only few species have been studied for biological activity and chemical composition. P. gracilis Tul. Read More

    Anti-Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review.
    Adv Pharmacol Sci 2015 12;2015:507151. Epub 2015 May 12.
    Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
    Background. Heparin, used clinically as an anticoagulant, also has anti-inflammatory properties. The purpose of this systematic review was to provide a comprehensive review regarding the efficacy and safety of heparin and its derivatives as anti-inflammatory agents. Read More

    Liver fibrosis and protection mechanisms action of medicinal plants targeting apoptosis of hepatocytes and hepatic stellate cells.
    Adv Pharmacol Sci 2014 20;2014:373295. Epub 2014 Nov 20.
    Catedra de Terapia Celular, Escuela de Medicina, Tecnológico de Monterrey, Avenida Morones Prieto 3000 Pte., 64710 Monterrey, NL, Mexico.
    Following chronic liver injury, hepatocytes undergo apoptosis leading to activation of hepatic stellate cells (HSC). Consequently, activated HSC proliferate and produce excessive extracellular matrix, responsible for the scar formation. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Read More

    Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells.
    Adv Pharmacol Sci 2014 3;2014:847574. Epub 2014 Sep 3.
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran.
    Natural products are excellent resources for finding lead structures for the development of chemotherapeutic agents. Coumarins are a class of natural compounds found in a variety of plants. In this study, we evaluated the cytotoxic potential of coumarins isolated from Prangos ferulacea (L. Read More

    Development of an Antioxidant Phytoextract of Lantana grisebachii with Lymphoprotective Activity against In Vitro Arsenic Toxicity.
    Adv Pharmacol Sci 2014 5;2014:416761. Epub 2014 Jun 5.
    Facultad de Ciencias Agrarias, Universidad Nacional del Comahue, PROBIEN-CONICET/UNCO, CP 8300, Neuquén, 1400 Buenos Aires, Argentina.
    Phytochemicals have been presumed to possess prophylactic and curative properties in several pathologies, such as arsenic- (As-) induced immunosuppression. Our aim was to discover a lymphoprotective extract from Lantana grisebachii Stuck. (Verbenaceae) (LG). Read More

    Attenuation of Carcinogenesis and the Mechanism Underlying by the Influence of Indole-3-carbinol and Its Metabolite 3,3'-Diindolylmethane: A Therapeutic Marvel.
    Adv Pharmacol Sci 2014 8;2014:832161. Epub 2014 May 8.
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu 608 002, India.
    Rising evidence provides credible support towards the potential role of bioactive products derived from cruciferous vegetables such as broccoli, cauliflower, kale, cabbage, brussels sprouts, turnips, kohlrabi, bok choy, and radishes. Many epidemiological studies point out that Brassica vegetable protects humans against cancer since they are rich sources of glucosinolates in addition to possessing a high content of flavonoids, vitamins, and mineral nutrients. Indole-3-carbinol (I3C) belongs to the class of compounds called indole glucosinolate, obtained from cruciferous vegetables, and is well-known for tits anticancer properties. Read More

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